SIMILAR PATTERNS OF AMINO ACIDS FOR 5YW0_A_ACTA411

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3x PYRUVATE KINASE

(Saccharomyces
cerevisiae) 		PF00224
(PK)
PF02887
(PK_C) 		3 LYS A 413
LEU A 410
ARG A 409
 None
 0.89A 5yw0A-1a3xA:
undetectable		 5yw0A-1a3xA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkd SON OF SEVENLESS-1

(Homo sapiens) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 LYS S 602
LEU S 948
ARG S 950
 None
 0.82A 5yw0A-1bkdS:
0.0		 5yw0A-1bkdS:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 186
LEU A 174
ARG A 152
 PTR  A 185 ( 3.6A)
None
TPO  A 183 ( 2.8A)
 0.72A 5yw0A-1cm8A:
0.0		 5yw0A-1cm8A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvo FERTILITY INHIBITION
PROTEIN O

(Escherichia
coli) 		PF04352
(ProQ)
PF12602
(FinO_N) 		3 LYS A 125
LEU A  70
ARG A 122
 None
 0.94A 5yw0A-1dvoA:
0.0		 5yw0A-1dvoA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LYS A 167
LEU A 173
ARG A 199
 None
 0.81A 5yw0A-1fcpA:
0.0		 5yw0A-1fcpA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fyh INTERFERON GAMMA
RECEPTOR 1

(Homo sapiens) 		PF01108
(Tissue_fac)
PF07140
(IFNGR1) 		3 LYS B 174
LEU B 171
ARG B 153
 None
 0.68A 5yw0A-1fyhB:
0.0		 5yw0A-1fyhB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 LYS A 732
LEU A 734
ARG A 712
 None
 0.62A 5yw0A-1h54A:
0.0		 5yw0A-1h54A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1v CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Escherichia
coli) 		PF08299
(Bac_DnaA_C) 		3 LYS A 443
LEU A 447
ARG A 405
 None
 0.94A 5yw0A-1j1vA:
undetectable		 5yw0A-1j1vA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		3 LYS A 335
LEU A 325
ARG A 333
 None
 0.91A 5yw0A-1jmzA:
0.0		 5yw0A-1jmzA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 LYS A 497
LEU A 506
ARG A 499
 None
 0.89A 5yw0A-1lrwA:
0.0		 5yw0A-1lrwA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 LYS A1172
LEU A1174
ARG A 996
 None
 0.70A 5yw0A-1n5xA:
undetectable		 5yw0A-1n5xA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0s NAD-DEPENDENT MALIC
ENZYME

(Ascaris suum) 		PF00390
(malic)
PF03949
(Malic_M) 		3 LYS A 284
LEU A 281
ARG A 280
 None
 0.86A 5yw0A-1o0sA:
undetectable		 5yw0A-1o0sA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk8 RAT SYNAPSIN I

(Rattus
norvegicus) 		PF02078
(Synapsin)
PF02750
(Synapsin_C) 		3 LYS A 238
LEU A 235
ARG A 234
 None
 0.95A 5yw0A-1pk8A:
undetectable		 5yw0A-1pk8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qst TGCN5 HISTONE ACETYL
TRANSFERASE

(Tetrahymena
thermophila) 		PF00583
(Acetyltransf_1) 		3 LYS A  64
LEU A  65
ARG A  61
 None
 0.75A 5yw0A-1qstA:
undetectable		 5yw0A-1qstA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ri7 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF01037
(AsnC_trans_reg)
PF13404
(HTH_AsnC-type) 		3 LYS A 128
LEU A  88
ARG A 130
 None
 0.88A 5yw0A-1ri7A:
undetectable		 5yw0A-1ri7A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzq EQUINATOXIN II

(Actinia equina) 		PF06369
(Anemone_cytotox) 		3 LYS A 125
LEU A  48
ARG A 127
 None
 0.82A 5yw0A-1tzqA:
undetectable		 5yw0A-1tzqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuj PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Mus musculus) 		PF08513
(LisH) 		3 LYS A  64
LEU A  61
ARG A  60
 SO4  A1078 (-3.2A)
None
SO4  A1078 (-3.0A)
 0.92A 5yw0A-1uujA:
undetectable		 5yw0A-1uujA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 LYS A 497
LEU A 506
ARG A 499
 None
 0.86A 5yw0A-1w6sA:
undetectable		 5yw0A-1w6sA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb8 SUPEROXIDE DISMUTASE
[FE]

(Sulfolobus
solfataricus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 LYS A  54
LEU A  60
ARG A  51
 None
 0.91A 5yw0A-1wb8A:
undetectable		 5yw0A-1wb8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyy PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PH1519

(Pyrococcus
horikoshii) 		PF01037
(AsnC_trans_reg)
PF13404
(HTH_AsnC-type) 		3 LYS A 108
LEU A  68
ARG A 110
 None
GLN  A1001 (-3.9A)
GLN  A1001 (-3.5A)
 0.75A 5yw0A-2cyyA:
undetectable		 5yw0A-2cyyA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT

(Hyphomicrobium
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		3 LYS A 497
LEU A 506
ARG A 499
 None
 0.86A 5yw0A-2d0vA:
undetectable		 5yw0A-2d0vA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8n RECOVERIN

(Homo sapiens) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 LYS A 154
LEU A 185
ARG A 151
 None
 0.84A 5yw0A-2d8nA:
undetectable		 5yw0A-2d8nA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo1 LIN-12 PROTEIN

(Caenorhabditis
elegans) 		PF00023
(Ank)
PF12796
(Ank_2) 		3 LYS E1242
LEU E1247
ARG E1208
 None
 0.91A 5yw0A-2fo1E:
undetectable		 5yw0A-2fo1E:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gry KINESIN-LIKE PROTEIN
KIF2

(Homo sapiens) 		PF00225
(Kinesin) 		3 LYS A 425
LEU A 422
ARG A 417
 None
 0.86A 5yw0A-2gryA:
undetectable		 5yw0A-2gryA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsj PUTATIVE PLATELET
ACTIVATING FACTOR

(Streptococcus
pneumoniae) 		PF13472
(Lipase_GDSL_2) 		3 LYS A  20
LEU A  24
ARG A  60
 None
 0.89A 5yw0A-2hsjA:
undetectable		 5yw0A-2hsjA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 20

(Saccharomyces
cerevisiae) 		PF08612
(Med20) 		3 LYS A 123
LEU A 121
ARG A  40
 None
 0.85A 5yw0A-2hzsA:
undetectable		 5yw0A-2hzsA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		3 LYS A 256
LEU A 337
ARG A 333
 None
 0.61A 5yw0A-2jbrA:
undetectable		 5yw0A-2jbrA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Aquifex
aeolicus) 		PF00793
(DAHP_synth_1) 		3 LYS A1032
LEU A1029
ARG A1028
 None
 0.89A 5yw0A-2nxgA:
undetectable		 5yw0A-2nxgA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om5 CONTACTIN 2

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 LYS A  44
LEU A  82
ARG A  42
 None
 0.91A 5yw0A-2om5A:
undetectable		 5yw0A-2om5A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg6 CYTOCHROME P450 2A6

(Homo sapiens) 		PF00067
(p450) 		3 LYS A 463
LEU A 492
ARG A 461
 None
 0.90A 5yw0A-2pg6A:
undetectable		 5yw0A-2pg6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		3 LYS A 103
LEU A 100
ARG A  91
 None
 0.90A 5yw0A-2qqkA:
undetectable		 5yw0A-2qqkA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf7 CYTOCHROME C-552

(Escherichia
coli) 		PF02335
(Cytochrom_C552) 		3 LYS A 136
LEU A 133
ARG A 132
 None
 0.79A 5yw0A-2rf7A:
undetectable		 5yw0A-2rf7A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 LYS A 381
LEU A 378
ARG A 377
 None
 0.90A 5yw0A-2xaxA:
undetectable		 5yw0A-2xaxA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfa ACTIN
DEPOLYMERIZATION
FACTOR 2

(Plasmodium
berghei) 		PF00241
(Cofilin_ADF) 		3 LYS A  21
LEU A  23
ARG A  17
 None
 0.70A 5yw0A-2xfaA:
undetectable		 5yw0A-2xfaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuh TUBULIN-SPECIFIC
CHAPERONE C

(Homo sapiens) 		PF07986
(TBCC) 		3 LYS A  61
LEU A  63
ARG A  44
 None
 0.83A 5yw0A-2yuhA:
undetectable		 5yw0A-2yuhA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zat DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Sus scrofa) 		PF13561
(adh_short_C2) 		3 LYS A 125
LEU A 129
ARG A  78
 None
 0.93A 5yw0A-2zatA:
undetectable		 5yw0A-2zatA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1z HEMOLYMPH JUVENILE
HORMONE BINDING
PROTEIN

(Bombyx mori) 		PF06585
(JHBP) 		3 LYS A  90
LEU A  88
ARG A 127
 None
 0.93A 5yw0A-3a1zA:
undetectable		 5yw0A-3a1zA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkz THIOESTERASE
SUPERFAMILY PROTEIN

(Bordetella
parapertussis) 		PF03061
(4HBT) 		3 LYS A 154
LEU A 151
ARG A 145
 None
 0.77A 5yw0A-3dkzA:
undetectable		 5yw0A-3dkzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5b ISOCITRATE LYASE

(Brucella
abortus) 		PF00463
(ICL) 		3 LYS A  51
LEU A  52
ARG A  48
 None
 0.93A 5yw0A-3e5bA:
undetectable		 5yw0A-3e5bA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edl KINESIN13 MOTOR
DOMAIN

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		3 LYS D 301
LEU D 298
ARG D 293
 None
 0.92A 5yw0A-3edlD:
undetectable		 5yw0A-3edlD:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elu METHYLTRANSFERASE

(Wesselsbron
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 LYS A 101
LEU A  78
ARG A  76
 None
 0.94A 5yw0A-3eluA:
undetectable		 5yw0A-3eluA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrx PROBABLE ENOYL-COA
HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 LYS A   4
LEU A  11
ARG A   6
 None
 0.87A 5yw0A-3hrxA:
undetectable		 5yw0A-3hrxA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		3 LYS A 293
LEU A  55
ARG A 297
 None
 0.89A 5yw0A-3iv3A:
undetectable		 5yw0A-3iv3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S17,
MITOCHONDRIAL
28S RIBOSOMAL
PROTEIN S25,
MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00366
(Ribosomal_S17)
PF14955
(MRP-S24) 		3 LYS Q  41
LEU Q  39
ARG c  11
 G  A 301 ( 4.8A)
None
C  A 282 ( 3.2A)
 0.89A 5yw0A-3jd5Q:
undetectable		 5yw0A-3jd5Q:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Homo sapiens) 		PF00621
(RhoGEF) 		3 LYS A 998
LEU A1003
ARG A 939
 None
 0.78A 5yw0A-3kz1A:
undetectable		 5yw0A-3kz1A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		3 LYS A 273
LEU A 257
ARG A 261
 SO4  A 492 ( 4.0A)
None
None
 0.88A 5yw0A-3nv9A:
undetectable		 5yw0A-3nv9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4r DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4

(Homo sapiens) 		PF13561
(adh_short_C2) 		3 LYS A 143
LEU A 147
ARG A  96
 None
 0.92A 5yw0A-3o4rA:
undetectable		 5yw0A-3o4rA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		3 LYS A  79
LEU A  31
ARG A  35
 None
 0.78A 5yw0A-3oyrA:
undetectable		 5yw0A-3oyrA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8a UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF13468
(Glyoxalase_3) 		3 LYS A 180
LEU A 181
ARG A 177
 None
 0.65A 5yw0A-3p8aA:
undetectable		 5yw0A-3p8aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		3 LYS B 284
LEU B 280
ARG B 320
 None
 0.89A 5yw0A-3p8cB:
undetectable		 5yw0A-3p8cB:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A  85
LEU A  82
ARG A  81
 None
 0.92A 5yw0A-3sjnA:
undetectable		 5yw0A-3sjnA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd6 ERYTHROID
TRANSCRIPTION FACTOR

(Mus musculus) 		PF00320
(GATA) 		3 LYS C 287
LEU C 284
ARG C 270
 None
 0.90A 5yw0A-3vd6C:
undetectable		 5yw0A-3vd6C:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Streptomyces
chartreusis) 		PF01370
(Epimerase) 		3 LYS A 113
LEU A  72
ARG A  71
 None
 0.86A 5yw0A-3vpsA:
undetectable		 5yw0A-3vpsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj7 PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF01370
(Epimerase) 		3 LYS A 169
LEU A 165
ARG A 164
 None
 0.55A 5yw0A-3wj7A:
undetectable		 5yw0A-3wj7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		3 LYS A 261
LEU A 258
ARG A 257
 None
 0.94A 5yw0A-3zrpA:
undetectable		 5yw0A-3zrpA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayx ATP-BINDING CASSETTE
SUB-FAMILY B MEMBER
10

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		3 LYS A 457
LEU A 281
ARG A 284
 None
 0.85A 5yw0A-4ayxA:
undetectable		 5yw0A-4ayxA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		3 LYS A  90
LEU A  91
ARG A  87
 None
 0.67A 5yw0A-4b8sA:
undetectable		 5yw0A-4b8sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdw LEUCINE RICH
HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF07523
(Big_3)
PF13306
(LRR_5) 		3 LYS A 251
LEU A 250
ARG A 273
 None
 0.92A 5yw0A-4fdwA:
undetectable		 5yw0A-4fdwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		3 LYS A  12
LEU A   9
ARG A   8
 None
 0.76A 5yw0A-4gp1A:
undetectable		 5yw0A-4gp1A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A  87
LEU A  84
ARG A  83
 None
 0.78A 5yw0A-4h19A:
undetectable		 5yw0A-4h19A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8n CONJUGATED
POLYKETONE REDUCTASE
C2

(Candida
parapsilosis) 		PF00248
(Aldo_ket_red) 		3 LYS A 238
LEU A 235
ARG A 234
 None
 0.82A 5yw0A-4h8nA:
undetectable		 5yw0A-4h8nA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld1 UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF07202
(Tcp10_C) 		3 LYS A 965
LEU A 967
ARG A 955
 None
 0.54A 5yw0A-4ld1A:
undetectable		 5yw0A-4ld1A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg2 POLYMERASE COFACTOR

(Reston
ebolavirus) 		PF02097
(Filo_VP35) 		3 LYS A 323
LEU A 325
ARG A 289
 None
 0.74A 5yw0A-4lg2A:
undetectable		 5yw0A-4lg2A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 LYS A 179
LEU A 175
ARG A 174
 None
 0.72A 5yw0A-4lvcA:
undetectable		 5yw0A-4lvcA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nww CAPSID PROTEIN

(Orsay virus) 		PF11729
(Capsid-VNN) 		3 LYS A  51
LEU A  49
ARG A  97
 None
 0.95A 5yw0A-4nwwA:
undetectable		 5yw0A-4nwwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2l GTP-BINDING PROTEIN
RHEB

(Mus musculus) 		PF00071
(Ras) 		3 LYS A 161
LEU A 165
ARG A 162
 None
 0.88A 5yw0A-4o2lA:
undetectable		 5yw0A-4o2lA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyu MUSKELIN

(Rattus
norvegicus) 		PF06588
(Muskelin_N) 		3 LYS A 182
LEU A 179
ARG A 178
 None
 0.96A 5yw0A-4oyuA:
undetectable		 5yw0A-4oyuA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT

(Methylococcus
capsulatus) 		no annotation 3 LYS B 518
LEU B 527
ARG B 520
 None
 0.94A 5yw0A-4tqoB:
undetectable		 5yw0A-4tqoB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 3 LYS C 336
LEU C 323
ARG C 421
 None
 0.72A 5yw0A-4tzcC:
undetectable		 5yw0A-4tzcC:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 LYS A  45
LEU A  42
ARG A  41
 None
 0.76A 5yw0A-4uzsA:
undetectable		 5yw0A-4uzsA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		3 LYS A 398
LEU A 402
ARG A 367
 None
 0.93A 5yw0A-4wyiA:
undetectable		 5yw0A-4wyiA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrn ALGINATE
BIOSYNTHESIS PROTEIN
ALG44

(Pseudomonas
aeruginosa) 		PF07238
(PilZ) 		3 LYS A  57
LEU A  59
ARG A  18
 None
 0.91A 5yw0A-4xrnA:
undetectable		 5yw0A-4xrnA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		3 LYS A1172
LEU A1174
ARG A 996
 None
 0.82A 5yw0A-4yswA:
undetectable		 5yw0A-4yswA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxm DNA INTEGRITY
SCANNING PROTEIN
DISA

(Thermotoga
maritima) 		PF00633
(HHH)
PF02457
(DisA_N)
PF10635
(DisA-linker) 		3 LYS A 195
LEU A 171
ARG A 191
 None
 0.90A 5yw0A-4yxmA:
undetectable		 5yw0A-4yxmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		3 LYS A 951
LEU A 876
ARG A 830
 None
 0.93A 5yw0A-4zmhA:
undetectable		 5yw0A-4zmhA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 3 LYS A  26
LEU A  28
ARG A  32
 None
 0.93A 5yw0A-5affA:
undetectable		 5yw0A-5affA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm8 RAS-RELATED PROTEIN
RAL-A

(Drosophila
melanogaster) 		PF00071
(Ras) 		3 LYS B  13
LEU B  11
ARG B  49
 None
 0.85A 5yw0A-5cm8B:
undetectable		 5yw0A-5cm8B:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 LYS A 447
LEU A 448
ARG A 444
 None
 0.76A 5yw0A-5d6bA:
undetectable		 5yw0A-5d6bA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqq TWO PORE CALCIUM
CHANNEL PROTEIN 1

(Arabidopsis
thaliana) 		PF00520
(Ion_trans) 		3 LYS A 156
LEU A 152
ARG A 203
 None
 0.91A 5yw0A-5dqqA:
undetectable		 5yw0A-5dqqA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Homo sapiens) 		PF01652
(IF4E) 		3 LYS A 162
LEU A 114
ARG A 112
 SO4  A 302 ( 3.9A)
None
5O8  A 301 (-3.5A)
 0.92A 5yw0A-5ei3A:
undetectable		 5yw0A-5ei3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		3 LYS A 122
LEU A 119
ARG A 118
 None
 0.85A 5yw0A-5fshA:
undetectable		 5yw0A-5fshA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp7 TANKYRASE-1

(Homo sapiens) 		PF13637
(Ank_4)
PF13857
(Ank_5) 		3 LYS A 821
LEU A 822
ARG A 818
 None
 0.92A 5yw0A-5gp7A:
undetectable		 5yw0A-5gp7A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		3 LYS A  36
LEU A  88
ARG A  43
 None
 0.87A 5yw0A-5gsmA:
undetectable		 5yw0A-5gsmA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE

(Homo sapiens) 		PF00632
(HECT) 		3 LYS A 865
LEU A 869
ARG A 938
 None
 0.80A 5yw0A-5hpkA:
undetectable		 5yw0A-5hpkA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  32
LEU A  41
ARG A  34
 None
 0.71A 5yw0A-5j5tA:
undetectable		 5yw0A-5j5tA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT I

(Oryctolagus
cuniculus) 		PF00400
(WD40) 		3 LYS T  91
LEU T  89
ARG T  77
 None
 0.91A 5yw0A-5k0yT:
undetectable		 5yw0A-5k0yT:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 LYS A 379
LEU A 383
ARG A 380
 1PE  A2007 (-2.7A)
None
None
 0.82A 5yw0A-5kf7A:
undetectable		 5yw0A-5kf7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szq PROTOCADHERIN
GAMMA-A4

(Mus musculus) 		PF00028
(Cadherin) 		3 LYS A 562
LEU A 559
ARG A 599
 None
 0.88A 5yw0A-5szqA:
undetectable		 5yw0A-5szqA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szr PROTEIN PCDHGB2

(Mus musculus) 		PF00028
(Cadherin) 		3 LYS A 560
LEU A 557
ARG A 597
 None
 0.87A 5yw0A-5szrA:
undetectable		 5yw0A-5szrA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A 126
LEU A 135
ARG A 128
 None
 0.88A 5yw0A-5vcxA:
undetectable		 5yw0A-5vcxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		3 LYS A 171
LEU A 168
ARG A 167
 None
 0.92A 5yw0A-5vn6A:
9.7		 5yw0A-5vn6A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpw 11S GLOBULIN ISOFORM
1

(Cocos nucifera) 		no annotation 3 LYS A 446
LEU A 447
ARG A 443
 None
 0.66A 5yw0A-5wpwA:
3.1		 5yw0A-5wpwA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 3 LYS A 528
LEU A 537
ARG A 530
 None
 0.87A 5yw0A-5xm3A:
undetectable		 5yw0A-5xm3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuo POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 3 LYS A 728
LEU A 732
ARG A 733
 None
 0.93A 5yw0A-5xuoA:
undetectable		 5yw0A-5xuoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yeu -

(-) 		no annotation 3 LYS A 442
LEU A 440
ARG A 286
 None
 0.74A 5yw0A-5yeuA:
undetectable		 5yw0A-5yeuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 3 LYS 4 254
LEU 4 253
ARG 4 384
 None
 0.87A 5yw0A-5zvs4:
undetectable		 5yw0A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 3 LYS B 173
LEU B 175
ARG B 170
 None
 0.91A 5yw0A-6czaB:
undetectable		 5yw0A-6czaB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6el1 YAXB

(Yersinia
enterocolitica) 		no annotation 3 LYS O 101
LEU O  91
ARG O 108
 None
 0.94A 5yw0A-6el1O:
undetectable		 5yw0A-6el1O:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 3 LYS A 257
LEU A 254
ARG A 253
 None
 0.84A 5yw0A-6ercA:
undetectable		 5yw0A-6ercA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 3 LYS A 289
LEU A 286
ARG A 285
 None
 0.95A 5yw0A-6fn1A:
undetectable		 5yw0A-6fn1A:
undetectable