SIMILAR PATTERNS OF AMINO ACIDS FOR 5YU9_C_1E8C1101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 416
ALA A 428
MET A 449
GLY A 480
CYH A 481
ASP A 539
None
0.89A 5yu9C-1k2pA:
28.4
5yu9C-1k2pA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
5 VAL A 209
ALA A 220
GLY A 272
ASP A 276
ASP A 332
None
0.71A 5yu9C-1k9aA:
29.6
5yu9C-1k9aA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
5 VAL A 219
ALA A 230
LEU A 278
GLY A 286
ASP A 351
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-2.7A)
0.68A 5yu9C-1py5A:
24.3
5yu9C-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
6 VAL A 219
ALA A 230
LYS A 232
GLY A 286
ASP A 290
ASP A 351
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-3.6A)
None
PY1  A 700 (-2.7A)
1.00A 5yu9C-1py5A:
24.3
5yu9C-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  99
LYS A 101
MET A 147
GLY A 153
ASP A 212
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 ( 3.4A)
ATP  A 535 ( 4.7A)
MG  A 536 (-3.3A)
0.74A 5yu9C-1s9iA:
16.0
5yu9C-1s9iA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  86
ALA A  99
LYS A 101
GLY A 153
ASP A 212
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 ( 4.7A)
MG  A 536 (-3.3A)
0.62A 5yu9C-1s9iA:
16.0
5yu9C-1s9iA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 377
ALA A 389
LYS A 391
LEU A 433
GLY A 441
ASP A 445
ASP A 500
None
0.93A 5yu9C-1snxA:
22.6
5yu9C-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 377
ALA A 389
LYS A 391
LEU A 433
GLY A 441
CYH A 442
ASP A 445
None
0.83A 5yu9C-1snxA:
22.6
5yu9C-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  78
ALA A  91
LYS A  93
LEU A 144
MET A 146
AIZ  A 501 ( 4.7A)
AIZ  A 501 (-3.4A)
AIZ  A 501 (-3.8A)
AIZ  A 501 (-4.2A)
AIZ  A 501 (-3.8A)
0.45A 5yu9C-2b1pA:
18.0
5yu9C-2b1pA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
ASP A 404
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.2A)
0.70A 5yu9C-2h8hA:
32.1
5yu9C-2h8hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
ASP A 404
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.1A)
None
0.98A 5yu9C-2hckA:
30.2
5yu9C-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
GLY A 420
ASP A 479
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 ( 3.9A)
MG  A 614 ( 3.2A)
0.76A 5yu9C-2ozoA:
22.7
5yu9C-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
6 VAL A 352
ALA A 367
MET A 390
MET A 414
GLY A 420
ASP A 479
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 ( 3.9A)
MG  A 614 ( 3.2A)
1.18A 5yu9C-2ozoA:
22.7
5yu9C-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
6 VAL A 352
LYS A 369
MET A 390
LEU A 412
GLY A 418
ASP A 479
ANP  A 615 (-4.5A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 ( 4.0A)
MG  A 614 ( 3.2A)
1.01A 5yu9C-2ozoA:
22.7
5yu9C-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus)
PF00069
(Pkinase)
6 VAL A  33
ALA A  46
LEU A 101
GLY A 109
ASP A 113
THR A 166
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
None
ATP  A 381 ( 4.6A)
0.71A 5yu9C-2phkA:
21.6
5yu9C-2phkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium)
PF07714
(Pkinase_Tyr)
6 VAL B  55
ALA B  67
LYS B  69
LEU B 112
GLY B 120
THR B 181
None
0.72A 5yu9C-2qkwB:
21.9
5yu9C-2qkwB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 204
ALA A 215
LEU A 263
GLY A 271
ASP A 275
ASP A 339
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.1A)
None
None
0.82A 5yu9C-2qluA:
23.7
5yu9C-2qluA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 204
ALA A 215
LYS A 217
LEU A 263
ASP A 275
ASP A 339
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
None
0.97A 5yu9C-2qluA:
23.7
5yu9C-2qluA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 749
LYS A 751
LEU A 794
ARG A 847
THR A 860
ASP A 861
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
None
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
1.35A 5yu9C-2r4bA:
37.2
5yu9C-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LYS A 751
MET A 772
LEU A 794
THR A 860
ASP A 861
GW7  A   1 (-3.9A)
GW7  A   1 ( 3.8A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
0.75A 5yu9C-2r4bA:
37.2
5yu9C-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 732
ALA A 749
LYS A 751
LEU A 794
GLY A 802
THR A 860
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.6A)
GW7  A   1 (-3.5A)
0.75A 5yu9C-2r4bA:
37.2
5yu9C-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 732
ALA A 749
LYS A 751
LEU A 794
THR A 860
ASP A 861
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
0.65A 5yu9C-2r4bA:
37.2
5yu9C-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 234
ALA A 247
GLY A 307
ASP A 311
THR A 367
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-3.7A)
0.48A 5yu9C-2xk9A:
11.7
5yu9C-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 234
ALA A 247
LYS A 249
GLY A 307
ASP A 311
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 ( 3.7A)
None
0.79A 5yu9C-2xk9A:
11.7
5yu9C-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  38
ALA A  51
GLY A 113
ASP A 117
ASP A 171
None
B49  A1294 (-3.2A)
B49  A1294 (-3.6A)
None
B49  A1294 (-4.2A)
0.70A 5yu9C-2y7jA:
21.9
5yu9C-2y7jA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  38
ALA A  51
LEU A 105
GLY A 113
ASP A 117
None
B49  A1294 (-3.2A)
None
B49  A1294 (-3.6A)
None
0.49A 5yu9C-2y7jA:
21.9
5yu9C-2y7jA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  76
ALA A  92
LYS A  94
LEU A 139
THR A 204
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 (-3.6A)
0.69A 5yu9C-2z7rA:
21.8
5yu9C-2z7rA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 VAL A 261
ALA A 273
LYS A 275
GLY A 325
ASP A 329
None
0.73A 5yu9C-2zv7A:
25.2
5yu9C-2zv7A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 209
ALA A 220
GLY A 272
ASP A 276
ASP A 332
None
0.71A 5yu9C-3d7uA:
24.2
5yu9C-3d7uA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  31
ALA A  44
LYS A  46
MET A  67
LEU A  90
ASP A 102
ASP A 164
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
ANP  A   1 (-3.8A)
0.83A 5yu9C-3dakA:
22.4
5yu9C-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  31
ALA A  44
MET A  67
LEU A  90
GLY A  98
ASP A 164
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
None
ANP  A   1 (-3.8A)
0.77A 5yu9C-3dakA:
22.4
5yu9C-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 158
ALA A 169
LEU A 218
GLY A 226
THR A 293
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-3.4A)
VIN  A6331 (-3.6A)
0.48A 5yu9C-3dtcA:
19.7
5yu9C-3dtcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3


(Toxoplasma
gondii)
PF00069
(Pkinase)
5 VAL A  37
ALA A  50
LEU A  98
ASP A 110
ASP A 167
None
0.57A 5yu9C-3dxnA:
24.6
5yu9C-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3


(Toxoplasma
gondii)
PF00069
(Pkinase)
5 VAL A  37
ALA A  50
LEU A  98
GLY A 106
ASP A 167
None
0.55A 5yu9C-3dxnA:
24.6
5yu9C-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2


(Homo sapiens)
PF00069
(Pkinase)
PF00498
(FHA)
5 ALA A 247
GLY A 307
ASP A 311
THR A 367
ASP A 368
None
0.69A 5yu9C-3i6uA:
22.2
5yu9C-3i6uA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 704
LYS A 723
LEU A 766
GLY A 774
ASP A 778
ASP A 833
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.9A)
None
MG  A1001 ( 3.1A)
0.70A 5yu9C-3kexA:
30.1
5yu9C-3kexA:
15.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 ALA A 719
LYS A 721
MET A 742
LEU A 764
GLY A 772
CYH A 773
ASP A 776
THR A 830
ASP A 831
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.76A 5yu9C-3lzbA:
38.9
5yu9C-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 LEU A 753
GLY A 772
CYH A 773
ASP A 776
THR A 830
ASP A 831
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
1.29A 5yu9C-3lzbA:
38.9
5yu9C-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 VAL A 702
ALA A 719
LYS A 721
MET A 742
LEU A 764
CYH A 773
ASP A 776
THR A 830
ASP A 831
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
0.75A 5yu9C-3lzbA:
38.9
5yu9C-3lzbA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A1096
ALA A1112
LYS A1114
GLY A1167
ASP A1226
ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
ANP  A1358 (-3.2A)
None
MG  A   1 ( 3.2A)
0.65A 5yu9C-3plsA:
30.4
5yu9C-3plsA:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 734
ALA A 751
LEU A 796
GLY A 804
CYH A 805
ASP A 808
ASP A 863
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 ( 3.9A)
None
None
03Q  A   1 (-4.0A)
0.85A 5yu9C-3pp0A:
34.8
5yu9C-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 734
ALA A 751
LEU A 796
GLY A 804
CYH A 805
ASP A 808
THR A 862
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
03Q  A   1 ( 3.9A)
None
None
03Q  A   1 (-3.3A)
0.62A 5yu9C-3pp0A:
34.8
5yu9C-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 734
ALA A 751
LYS A 753
LEU A 796
CYH A 805
ASP A 863
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-4.0A)
1.11A 5yu9C-3pp0A:
34.8
5yu9C-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 734
ALA A 751
LYS A 753
LEU A 796
CYH A 805
THR A 862
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-3.3A)
0.92A 5yu9C-3pp0A:
34.8
5yu9C-3pp0A:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
5 VAL A  65
ALA A  78
LYS A  80
LEU A 126
ASP A 195
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
BK5  A 701 (-4.0A)
0.39A 5yu9C-3sxfA:
23.6
5yu9C-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 431
ALA A 443
LYS A 445
GLY A 495
CYH A 496
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.2A)
None
0.80A 5yu9C-3sxsA:
28.9
5yu9C-3sxsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
6 VAL A 303
ALA A 315
LYS A 317
LEU A 361
GLY A 369
ASP A 434
None
1.03A 5yu9C-3ulzA:
21.2
5yu9C-3ulzA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  83
ALA A  96
LYS A  98
MET A 144
GLY A 150
ASP A 209
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 ( 4.3A)
MG  A 402 (-3.2A)
0.76A 5yu9C-3wigA:
23.4
5yu9C-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  91
ALA A 104
LYS A 106
LEU A 152
GLY A 160
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-3.3A)
0.71A 5yu9C-4af3A:
18.9
5yu9C-4af3A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
7 VAL A 222
ALA A 233
LYS A 235
LEU A 281
GLY A 289
ASP A 293
ASP A 354
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.5A)
None
TAK  A1507 (-3.5A)
0.88A 5yu9C-4c02A:
24.5
5yu9C-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus)
PF00069
(Pkinase)
5 VAL A  24
ALA A  37
LYS A  39
LEU A  85
ASP A 151
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.1A)
None
None
0.75A 5yu9C-4eqmA:
23.0
5yu9C-4eqmA:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 385
ALA A 400
LYS A 402
LEU A 446
GLY A 454
ASP A 512
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-3.5A)
0SB  A 701 (-3.9A)
1.06A 5yu9C-4f4pA:
25.7
5yu9C-4f4pA:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
7 VAL A 385
ALA A 400
LYS A 402
MET A 424
LEU A 446
GLY A 454
ASP A 512
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
None
ANP  A 701 ( 4.2A)
MG  A 702 ( 3.1A)
0.55A 5yu9C-4fl3A:
31.3
5yu9C-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
6 VAL A 385
ALA A 400
LYS A 402
MET A 448
GLY A 454
ASP A 512
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
ANP  A 701 ( 4.2A)
MG  A 702 ( 3.1A)
0.84A 5yu9C-4fl3A:
31.3
5yu9C-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 VAL A 863
ALA A 880
LEU A 927
GLY A 935
ASP A 939
ASP A 994
None
IZA  A2001 (-3.4A)
None
IZA  A2001 (-3.3A)
None
IZA  A2001 ( 4.5A)
1.09A 5yu9C-4gl9A:
21.7
5yu9C-4gl9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 836
ALA A 853
LEU A 900
GLY A 908
CYH A 909
ASP A 912
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
19S  A1201 ( 3.8A)
None
None
0.91A 5yu9C-4hviA:
29.4
5yu9C-4hviA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14604
(SH3_9)
7 VAL A 140
ALA A 156
LYS A 158
MET A 181
GLY A 211
ASP A 215
ASP A 270
None
0.75A 5yu9C-4hzsA:
31.0
5yu9C-4hzsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 140
ALA A 156
LYS A 158
GLY A 211
ASP A 215
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 ( 4.5A)
None
0.68A 5yu9C-4id7A:
24.4
5yu9C-4id7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 VAL A 281
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
ASP A 404
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-3.1A)
0.65A 5yu9C-4k11A:
32.1
5yu9C-4k11A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 421
ALA A 434
GLY A 487
ASP A 491
ASP A 544
None
B49  A 701 (-3.2A)
B49  A 701 ( 3.7A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.6A)
0.70A 5yu9C-4ks8A:
23.0
5yu9C-4ks8A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
5 VAL A 281
ALA A 293
LYS A 295
GLY A 344
ASP A 348
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.2A)
None
0.66A 5yu9C-4lggA:
27.7
5yu9C-4lggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3


(Mus musculus)
PF00069
(Pkinase)
6 VAL A  36
ALA A  49
LYS A  51
LEU A  93
GLY A 101
ASP A 161
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
MG  A 403 ( 3.1A)
0.83A 5yu9C-4m69A:
26.4
5yu9C-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3


(Mus musculus)
PF00069
(Pkinase)
6 VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A  93
GLY A 101
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
None
1.13A 5yu9C-4m69A:
26.4
5yu9C-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
6 VAL A  27
ALA A  40
LYS A  42
LEU A  93
THR A 158
ASP A 159
None
0.82A 5yu9C-4ow8A:
23.6
5yu9C-4ow8A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4


(Plasmodium
falciparum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
5 VAL A  84
ALA A  97
LYS A  99
LEU A 145
ASP A 215
None
0.37A 5yu9C-4rgjA:
23.1
5yu9C-4rgjA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 138
ALA A 149
LEU A 198
GLY A 206
THR A 288
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
None
AGS  A1438 ( 4.7A)
0.63A 5yu9C-4uyaA:
25.7
5yu9C-4uyaA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 VAL A 416
ALA A 428
MET A 449
GLY A 480
CYH A 481
ASP A 539
None
0.82A 5yu9C-4xi2A:
29.9
5yu9C-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
5 VAL A 416
ALA A 428
GLY A 480
CYH A 481
ASP A 539
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.6A)
None
746  A 702 (-3.7A)
0.51A 5yu9C-4y93A:
30.3
5yu9C-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  18
ALA A  31
LYS A  33
LEU A  78
ASP A 146
None
0.65A 5yu9C-4yc6A:
23.7
5yu9C-4yc6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2


(Mus musculus)
PF00069
(Pkinase)
5 VAL A  34
ALA A  47
LYS A  49
LEU A  94
ASP A 160
None
0.57A 5yu9C-4ynzA:
21.3
5yu9C-4ynzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  30
ALA A  44
LYS A  46
LEU A  90
GLY A  98
ASP A 165
51W  A 401 ( 4.3A)
51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.7A)
GOL  A 404 (-3.2A)
1.04A 5yu9C-5ci7A:
21.6
5yu9C-5ci7A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE


(Mus musculus)
PF00069
(Pkinase)
5 VAL A  89
ALA A 102
LYS A 104
LEU A 148
ASP A 160
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
0.70A 5yu9C-5dbxA:
22.0
5yu9C-5dbxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis)
PF00069
(Pkinase)
5 VAL A 107
ALA A 120
LYS A 122
LEU A 168
GLY A 176
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
0.61A 5yu9C-5eykA:
15.7
5yu9C-5eykA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 928
LYS A 930
MET A 978
ASP A 988
ARG A1027
ASP A1041
5U3  A1200 (-3.5A)
None
5U3  A1200 ( 4.0A)
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
1.32A 5yu9C-5f1zA:
28.3
5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ALA A 928
MET A 978
GLY A 984
ASP A 988
ARG A1027
ASP A1041
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-3.2A)
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
1.16A 5yu9C-5f1zA:
28.3
5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 911
ALA A 928
GLY A 984
ASP A 988
ARG A1027
ASP A1041
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-3.2A)
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
1.05A 5yu9C-5f1zA:
28.3
5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 911
ALA A 928
LYS A 930
ASP A 988
ARG A1027
ASP A1041
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
1.21A 5yu9C-5f1zA:
28.3
5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 911
LEU A 976
GLY A 984
ASP A 988
ARG A1027
ASP A1041
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-3.2A)
None
5U3  A1200 ( 4.5A)
5U3  A1200 ( 4.9A)
1.37A 5yu9C-5f1zA:
28.3
5yu9C-5f1zA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 738
ALA A 756
LYS A 758
LEU A 802
GLY A 810
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
0.55A 5yu9C-5fm2A:
28.3
5yu9C-5fm2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE


(Salpingoeca
rosetta)
PF00069
(Pkinase)
5 VAL A  32
ALA A  45
LEU A  92
GLY A 100
THR A 160
None
0.76A 5yu9C-5ig1A:
22.3
5yu9C-5ig1A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE


(Salpingoeca
rosetta)
PF00069
(Pkinase)
5 VAL A  32
ALA A  45
LYS A  47
LEU A  92
THR A 160
None
0.79A 5yu9C-5ig1A:
22.3
5yu9C-5ig1A:
12.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 726
ALA A 743
LEU A 788
MET A 790
GLY A 796
CYH A 797
ASP A 800
THR A 854
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 (-3.9A)
0.49A 5yu9C-5j9zA:
35.2
5yu9C-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 726
ALA A 743
LYS A 745
LEU A 788
MET A 790
GLY A 796
CYH A 797
THR A 854
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 (-3.9A)
0.72A 5yu9C-5j9zA:
35.2
5yu9C-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 726
ALA A 743
MET A 790
GLY A 796
CYH A 797
ASP A 800
THR A 854
ASP A 855
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
0.72A 5yu9C-5j9zA:
35.2
5yu9C-5j9zA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 404
ALA A 417
LEU A 463
GLY A 471
ASP A 475
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
0.53A 5yu9C-5jznA:
21.9
5yu9C-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 404
ALA A 417
LYS A 419
LEU A 463
GLY A 471
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
GUI  A 701 (-3.6A)
0.73A 5yu9C-5jznA:
21.9
5yu9C-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 284
ALA A 297
GLY A 350
ASP A 354
THR A 406
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-3.7A)
0.68A 5yu9C-5kbrA:
21.4
5yu9C-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loh SERINE/THREONINE-PRO
TEIN KINASE
GREATWALL,SERINE/THR
EONINE-PROTEIN
KINASE GREATWALL


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  49
ALA A  60
LEU A 108
GLY A 116
THR A 173
None
STU  A 901 (-3.3A)
None
STU  A 901 (-3.5A)
STU  A 901 (-3.5A)
0.62A 5yu9C-5lohA:
16.9
5yu9C-5lohA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI


(Mycobacterium
tuberculosis)
PF00069
(Pkinase)
5 VAL A  26
ALA A  39
LYS A  41
MET A  89
ASP A 159
None
0.78A 5yu9C-5m09A:
21.0
5yu9C-5m09A:
13.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 6 VAL A 899
ALA A 917
LYS A 919
MET A 938
THR A1027
ASP A1028
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
0.96A 5yu9C-5wnoA:
34.5
5yu9C-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 6 VAL A 899
ALA A 917
MET A 938
GLY A 969
THR A1027
ASP A1028
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 ( 4.6A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
0.81A 5yu9C-5wnoA:
34.5
5yu9C-5wnoA:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN


(Arabidopsis
thaliana)
no annotation 5 VAL A  83
LYS A  97
LEU A 139
GLY A 147
ASP A 151
ANP  A1000 (-4.1A)
ANP  A1000 (-2.8A)
None
None
ANP  A1000 ( 4.9A)
0.75A 5yu9C-5xd6A:
23.7
5yu9C-5xd6A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53


(Saccharomyces
cerevisiae)
no annotation 6 VAL A 212
ALA A 225
GLY A 279
ASP A 283
THR A 338
ASP A 339
None
0.86A 5yu9C-5xzwA:
18.5
5yu9C-5xzwA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yks SNF-RELATED
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
no annotation 6 ALA A  43
LEU A  90
GLY A  98
ASP A 102
THR A 157
ASP A 158
None
0.93A 5yu9C-5yksA:
19.3
5yu9C-5yksA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 6 VAL A  41
ALA A  54
LYS A  56
MET A  74
GLY A 105
ASP A 164
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
ANP  A 501 ( 4.0A)
MG  A 502 ( 3.1A)
0.86A 5yu9C-6ao5A:
23.4
5yu9C-6ao5A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 6 VAL A  41
ALA A  54
LYS A  56
MET A  99
GLY A 105
ASP A 164
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
ANP  A 501 (-2.5A)
ANP  A 501 ( 4.0A)
MG  A 502 ( 3.1A)
0.77A 5yu9C-6ao5A:
23.4
5yu9C-6ao5A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1


(Homo sapiens)
no annotation 5 VAL A 226
ALA A 237
LEU A 286
GLY A 294
ASP A 358
None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.1A)
0.48A 5yu9C-6bfnA:
22.6
5yu9C-6bfnA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE


(Pediculus
humanus)
no annotation 5 VAL C 173
ALA C 191
LEU C 288
THR C 356
ASP C 357
None
0.57A 5yu9C-6eqiC:
19.6
5yu9C-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE


(Pediculus
humanus)
no annotation 6 VAL C 173
ALA C 191
LYS C 193
MET C 290
THR C 356
ASP C 357
None
1.22A 5yu9C-6eqiC:
19.6
5yu9C-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4


(Homo sapiens)
no annotation 5 VAL A 200
ALA A 211
LEU A 260
GLY A 268
ASP A 272
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
None
CJT  A 502 ( 4.3A)
CJT  A 502 (-3.3A)
0.59A 5yu9C-6f3dA:
22.0
5yu9C-6f3dA:
26.14