SIMILAR PATTERNS OF AMINO ACIDS FOR 5YU9_B_1E8B1101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
ASP A 276
LEU A 321
ASP A 332
 None
 0.75A 5yu9B-1k9aA:
30.1		 5yu9B-1k9aA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 212
VAL A 219
ALA A 230
LEU A 278
ASP A 290
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.8A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.82A 5yu9B-1py5A:
24.6		 5yu9B-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 212
VAL A 219
ALA A 230
LYS A 232
ASP A 290
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
None
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.97A 5yu9B-1py5A:
24.6		 5yu9B-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  79
ALA A  99
LYS A 101
MET A 147
LEU A 201
ASP A 212
 ATP  A 535 ( 3.9A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 ( 3.4A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
 0.76A 5yu9B-1s9iA:
13.9		 5yu9B-1s9iA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  79
VAL A  86
ALA A  99
LYS A 101
LEU A 201
ASP A 212
 ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
 0.62A 5yu9B-1s9iA:
13.9		 5yu9B-1s9iA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 370
VAL A 377
ALA A 389
LEU A 433
CYH A 442
ASP A 445
LEU A 489
 None
 0.73A 5yu9B-1snxA:
24.5		 5yu9B-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 377
ALA A 389
LEU A 433
CYH A 442
ASP A 445
LEU A 489
ASP A 500
 None
 0.78A 5yu9B-1snxA:
24.5		 5yu9B-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A 103
MET A 105
 None
 0.83A 5yu9B-1u5qA:
22.3		 5yu9B-1u5qA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  19
VAL A  26
ALA A  39
LYS A  41
LEU A  89
LEU A 144
 ATP  A 381 ( 3.9A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
None
 0.73A 5yu9B-1ua2A:
22.2		 5yu9B-1ua2A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 GLY A  11
VAL A  18
ALA A  30
LEU A  77
LEU A 132
ASP A 143
 None
 0.48A 5yu9B-1v0bA:
23.7		 5yu9B-1v0bA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
ASP A 348
LEU A 393
ASP A 404
 H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.70A 5yu9B-2h8hA:
32.7		 5yu9B-2h8hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
ASP A 348
LEU A 393
ASP A 404
 QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 ( 4.1A)
QUE  A   1 (-4.4A)
None
 0.92A 5yu9B-2hckA:
30.9		 5yu9B-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  11
VAL A  18
ALA A  31
LYS A  33
LEU A  78
LEU A 134
 None
 0.69A 5yu9B-2jgzA:
22.2		 5yu9B-2jgzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 GLY A 345
VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
LEU A 468
ASP A 479
 ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.78A 5yu9B-2ozoA:
30.9		 5yu9B-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 GLY A 345
VAL A 352
ALA A 367
LYS A 369
MET A 390
MET A 414
LEU A 468
ASP A 479
 ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 1.06A 5yu9B-2ozoA:
30.9		 5yu9B-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 GLY A  26
VAL A  33
ALA A  46
LEU A 101
ASP A 113
LEU A 156
THR A 166
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.86A 5yu9B-2phkA:
21.9		 5yu9B-2phkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 GLY B  48
VAL B  55
ALA B  67
LYS B  69
LEU B 112
LEU B 171
THR B 181
 None
 0.80A 5yu9B-2qkwB:
22.4		 5yu9B-2qkwB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
LYS A 217
LEU A 263
ASP A 275
LEU A 328
ASP A 339
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 (-4.4A)
None
 0.93A 5yu9B-2qluA:
23.9		 5yu9B-2qluA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 794
LEU A 850
THR A 860
ASP A 861
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.72A 5yu9B-2r4bA:
37.5		 5yu9B-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 751
MET A 772
LEU A 794
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 (-3.9A)
GW7  A   1 ( 3.8A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.85A 5yu9B-2r4bA:
37.5		 5yu9B-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 227
VAL A 234
ALA A 247
ASP A 311
LEU A 354
THR A 367
 XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.58A 5yu9B-2xk9A:
21.0		 5yu9B-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  31
VAL A  38
ALA A  51
LEU A 105
ASP A 117
LEU A 160
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-4.4A)
 0.73A 5yu9B-2y7jA:
22.4		 5yu9B-2y7jA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  69
VAL A  76
ALA A  92
LEU A 139
LEU A 194
THR A 204
 STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
None
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.86A 5yu9B-2z7rA:
22.4		 5yu9B-2z7rA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
ASP A 276
LEU A 321
ASP A 332
 None
 0.75A 5yu9B-3d7uA:
24.5		 5yu9B-3d7uA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		9 GLY A  24
VAL A  31
ALA A  44
LYS A  46
MET A  67
LEU A  90
ASP A 102
LEU A 153
ASP A 164
 ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
None
ANP  A   1 (-3.8A)
 0.98A 5yu9B-3dakA:
22.8		 5yu9B-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 151
VAL A 158
ALA A 169
LEU A 218
LEU A 275
THR A 293
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
 0.65A 5yu9B-3dtcA:
21.5		 5yu9B-3dtcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 GLY A  30
VAL A  37
ALA A  50
LEU A  98
ASP A 110
ASP A 167
 None
 0.82A 5yu9B-3dxnA:
24.8		 5yu9B-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 VAL A  37
ALA A  50
LEU A  98
ASP A 110
LEU A 153
ASP A 167
 None
 0.73A 5yu9B-3dxnA:
24.8		 5yu9B-3dxnA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  45
VAL A  52
ALA A  65
LEU A 118
ASP A 131
LEU A 174
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
None
None
985  A   1 (-4.8A)
 0.85A 5yu9B-3f2aA:
16.1		 5yu9B-3f2aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 432
VAL A 439
ALA A 455
LYS A 457
LEU A 556
ASP A 567
 AGS  A 999 ( 4.2A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-4.5A)
AGS  A 999 ( 3.9A)
 0.85A 5yu9B-3fzpA:
25.1		 5yu9B-3fzpA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		6 GLY A 227
VAL A 234
ALA A 247
LEU A 354
THR A 367
ASP A 368
 None
 0.76A 5yu9B-3i6uA:
22.2		 5yu9B-3i6uA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 697
VAL A 704
LYS A 723
LEU A 766
ASP A 778
LEU A 822
ASP A 833
 ANP  A   1 (-3.7A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
None
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
 0.83A 5yu9B-3kexA:
35.1		 5yu9B-3kexA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  69
VAL A  76
ALA A  89
LYS A  91
LEU A 136
LEU A 191
 ANP  A 522 (-3.5A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
None
ANP  A 522 (-4.7A)
 0.77A 5yu9B-3lijA:
23.0		 5yu9B-3lijA:
9.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 GLY A 695
VAL A 702
ALA A 719
LYS A 721
MET A 742
LEU A 764
CYH A 773
ASP A 776
LEU A 820
THR A 830
ASP A 831
 ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
 0.69A 5yu9B-3lzbA:
38.9		 5yu9B-3lzbA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 GLY A  30
VAL A  37
ALA A  49
LYS A  51
LEU A  96
LEU A 151
 ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 (-2.8A)
None
ADP  A 314 (-4.6A)
 0.89A 5yu9B-3nizA:
22.6		 5yu9B-3nizA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 193
VAL A 200
ALA A 213
LYS A 215
LEU A 261
LEU A 318
 AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 (-4.8A)
 0.81A 5yu9B-3nyoA:
21.1		 5yu9B-3nyoA:
9.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 GLY A 727
VAL A 734
ALA A 751
LEU A 796
CYH A 805
ASP A 808
LEU A 852
THR A 862
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.64A 5yu9B-3pp0A:
34.9		 5yu9B-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 727
VAL A 734
ALA A 751
MET A 774
CYH A 805
ASP A 808
THR A 862
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.5A)
None
None
03Q  A   1 (-3.3A)
 1.37A 5yu9B-3pp0A:
34.9		 5yu9B-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 734
ALA A 751
LEU A 796
CYH A 805
ASP A 808
LEU A 852
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
None
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.85A 5yu9B-3pp0A:
34.9		 5yu9B-3pp0A:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 GLY A  58
VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
 BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
 0.70A 5yu9B-3sxfA:
23.6		 5yu9B-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 424
VAL A 431
ALA A 443
LYS A 445
CYH A 496
LEU A 543
 PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-4.6A)
 0.81A 5yu9B-3sxsA:
23.6		 5yu9B-3sxsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 GLY A 296
VAL A 303
ALA A 315
LYS A 317
LEU A 361
LEU A 423
ASP A 434
 None
 0.94A 5yu9B-3ulzA:
21.5		 5yu9B-3ulzA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  60
VAL A  67
ALA A  80
MET A 129
LEU A 186
ASP A 197
 ANK  A 401 (-3.4A)
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
ANK  A 401 ( 4.9A)
MG  A 402 ( 2.8A)
 0.80A 5yu9B-3vn9A:
24.0		 5yu9B-3vn9A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  76
VAL A  83
ALA A  96
LYS A  98
MET A 144
ASP A 153
LEU A 198
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
None
ANP  A 401 (-4.8A)
 1.27A 5yu9B-3wigA:
23.3		 5yu9B-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  76
VAL A  83
ALA A  96
LYS A  98
MET A 144
LEU A 198
ASP A 209
 ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.81A 5yu9B-3wigA:
23.3		 5yu9B-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  11
VAL A  18
ALA A  31
LYS A  33
LEU A  78
LEU A 133
 D15  A 500 (-3.8A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.5A)
 0.65A 5yu9B-4aguA:
22.4		 5yu9B-4aguA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		8 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
ASP A 293
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.87A 5yu9B-4c02A:
25.0		 5yu9B-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 GLY A 247
VAL A 254
ALA A 267
LEU A 371
THR A 381
ASP A 382
 None
 0.81A 5yu9B-4c0tA:
20.6		 5yu9B-4c0tA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		6 GLY A  17
VAL A  24
ALA A  37
LYS A  39
LEU A  85
ASP A 151
 ANP  A 300 ( 4.4A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.1A)
None
None
 0.72A 5yu9B-4eqmA:
23.4		 5yu9B-4eqmA:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
LEU A 501
ASP A 512
 0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.97A 5yu9B-4f4pA:
25.5		 5yu9B-4f4pA:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		6 GLY A 328
VAL A 335
ALA A 348
LYS A 350
LEU A 447
ASP A 458
 ANP  A1001 (-4.4A)
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
ANP  A1001 (-4.7A)
ANP  A1001 (-2.7A)
 0.84A 5yu9B-4fieA:
21.8		 5yu9B-4fieA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 424
LEU A 446
LEU A 501
ASP A 512
 ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
None
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.59A 5yu9B-4fl3A:
24.8		 5yu9B-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 448
LEU A 501
ASP A 512
 ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.84A 5yu9B-4fl3A:
24.8		 5yu9B-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 856
VAL A 863
ALA A 880
LEU A 927
ASP A 939
LEU A 983
 IZA  A2001 ( 4.9A)
None
IZA  A2001 (-3.4A)
None
None
IZA  A2001 ( 4.7A)
 0.89A 5yu9B-4gl9A:
28.2		 5yu9B-4gl9A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 GLY A 133
VAL A 140
ALA A 156
LYS A 158
MET A 181
ASP A 215
LEU A 259
ASP A 270
 None
 0.76A 5yu9B-4hzsA:
31.3		 5yu9B-4hzsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 133
VAL A 140
ALA A 156
LYS A 158
MET A 181
ASP A 215
LEU A 259
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.0A)
None
1G0  A 401 (-4.6A)
 1.39A 5yu9B-4id7A:
29.7		 5yu9B-4id7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		7 GLY A 259
VAL A 266
ALA A 279
LYS A 281
LEU A 354
MET A 356
LEU A 416
 ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
None
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
 0.96A 5yu9B-4jrnA:
18.8		 5yu9B-4jrnA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
ASP A 348
LEU A 393
ASP A 404
 0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.61A 5yu9B-4k11A:
32.7		 5yu9B-4k11A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 414
VAL A 421
ALA A 434
ASP A 491
LEU A 533
ASP A 544
 B49  A 701 ( 4.3A)
None
B49  A 701 (-3.2A)
B49  A 701 ( 4.3A)
B49  A 701 (-4.5A)
B49  A 701 (-4.6A)
 0.72A 5yu9B-4ks8A:
23.2		 5yu9B-4ks8A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 274
VAL A 281
ALA A 293
LYS A 295
ASP A 348
LEU A 393
ASP A 404
 VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.85A 5yu9B-4lggA:
28.4		 5yu9B-4lggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  93
LEU A 150
ASP A 161
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.76A 5yu9B-4m69A:
26.5		 5yu9B-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  29
VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A  93
LEU A 150
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
ANP  A 401 (-4.8A)
 1.00A 5yu9B-4m69A:
26.5		 5yu9B-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ow8 SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 VAL A  27
ALA A  40
LYS A  42
LEU A  93
THR A 158
ASP A 159
 None
 0.83A 5yu9B-4ow8A:
23.7		 5yu9B-4ow8A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  77
VAL A  84
ALA A  97
LYS A  99
LEU A 145
ASP A 215
 None
 0.39A 5yu9B-4rgjA:
23.2		 5yu9B-4rgjA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 193
VAL A 200
ALA A 213
LEU A 261
LEU A 318
ASP A 329
 SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.74A 5yu9B-4tnbA:
19.7		 5yu9B-4tnbA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 131
VAL A 138
ALA A 149
LEU A 198
LEU A 270
THR A 288
 AGS  A1438 ( 3.8A)
AGS  A1438 (-4.4A)
AGS  A1438 (-3.4A)
None
AGS  A1438 (-4.7A)
AGS  A1438 ( 4.7A)
 0.75A 5yu9B-4uyaA:
26.0		 5yu9B-4uyaA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 GLY A 409
VAL A 416
ALA A 428
MET A 449
CYH A 481
LEU A 528
ASP A 539
 None
 0.88A 5yu9B-4xi2A:
26.7		 5yu9B-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 GLY A 409
VAL A 416
ALA A 428
CYH A 481
LEU A 528
ASP A 539
 746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.65A 5yu9B-4y93A:
30.7		 5yu9B-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 VAL A 416
ALA A 428
MET A 449
CYH A 481
LEU A 528
ASP A 539
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.86A 5yu9B-4y93A:
30.7		 5yu9B-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
VAL A  18
ALA A  31
LYS A  33
LEU A  78
LEU A 135
ASP A 146
 None
 0.68A 5yu9B-4yc6A:
23.8		 5yu9B-4yc6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 262
LEU A 319
 AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
 0.85A 5yu9B-4yhjA:
19.7		 5yu9B-4yhjA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  94
LEU A 149
ASP A 160
 None
 0.71A 5yu9B-4ynzA:
21.3		 5yu9B-4ynzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  82
VAL A  89
ALA A 102
LYS A 104
LEU A 148
ASP A 160
LEU A 211
 ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
None
 0.95A 5yu9B-5dbxA:
22.2		 5yu9B-5dbxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 251
VAL A 258
ALA A 275
LYS A 277
LEU A 323
LEU A 386
 STU  A 601 (-2.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
None
STU  A 601 (-3.9A)
 0.68A 5yu9B-5e8yA:
18.6		 5yu9B-5e8yA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-4.7A)
 0.72A 5yu9B-5eykA:
22.3		 5yu9B-5eykA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 802
LEU A 881
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.6A)
 0.52A 5yu9B-5fm2A:
29.0		 5yu9B-5fm2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 GLY A  25
VAL A  32
ALA A  45
LYS A  47
LEU A  92
THR A 160
 None
 0.87A 5yu9B-5ig1A:
22.8		 5yu9B-5ig1A:
12.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A 719
VAL A 726
ALA A 743
LEU A 788
MET A 790
CYH A 797
ASP A 800
LEU A 844
THR A 854
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.58A 5yu9B-5j9zA:
35.8		 5yu9B-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 719
VAL A 726
ALA A 743
LYS A 745
LEU A 788
MET A 790
LEU A 844
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.8A)
 0.66A 5yu9B-5j9zA:
35.8		 5yu9B-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 GLY A 719
VAL A 726
ALA A 743
MET A 790
CYH A 797
ASP A 800
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.74A 5yu9B-5j9zA:
35.8		 5yu9B-5j9zA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 397
VAL A 404
ALA A 417
LEU A 463
ASP A 475
LEU A 518
 GUI  A 701 ( 3.8A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.61A 5yu9B-5jznA:
22.4		 5yu9B-5jznA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 277
VAL A 284
ALA A 297
ASP A 354
LEU A 396
THR A 406
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.70A 5yu9B-5kbrA:
21.7		 5yu9B-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 277
VAL A 284
ALA A 297
LYS A 299
LEU A 396
THR A 406
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.61A 5yu9B-5kbrA:
21.7		 5yu9B-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 GLY A 890
VAL A 897
ALA A 909
LYS A 911
LEU A 954
LEU A1016
ASP A1027
 ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 0.90A 5yu9B-5lpyA:
22.0		 5yu9B-5lpyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 GLY A 890
VAL A 897
LYS A 911
LEU A 954
ASP A 966
LEU A1016
ASP A1027
 ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-3.9A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 1.04A 5yu9B-5lpyA:
22.0		 5yu9B-5lpyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 GLY A 890
VAL A 897
ALA A 909
LYS A 911
LEU A 954
ASP A 966
LEU A1016
ASP A1027
 ADP  A1200 ( 4.0A)
ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
ADP  A1200 (-4.2A)
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
 1.03A 5yu9B-5lpzA:
22.2		 5yu9B-5lpzA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		6 GLY A  19
VAL A  26
ALA A  39
LYS A  41
MET A  89
ASP A 159
 None
 0.78A 5yu9B-5m09A:
21.3		 5yu9B-5m09A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 6 GLY A 359
VAL A 366
ALA A 379
LYS A 381
LEU A 427
LEU A 482
 ANP  A 801 ( 4.1A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 3.9A)
ANP  A 801 (-2.6A)
None
ANP  A 801 (-4.8A)
 0.68A 5yu9B-5nclA:
19.0		 5yu9B-5nclA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 6 GLY A  45
VAL A  52
ALA A  65
LEU A 118
ASP A 131
LEU A 174
 None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
7LK  A 401 (-3.0A)
7LK  A 401 (-4.8A)
 0.84A 5yu9B-5turA:
21.9		 5yu9B-5turA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 7 GLY A 328
VAL A 335
ALA A 348
LYS A 350
MET A 395
LEU A 447
ASP A 458
 M77  A 601 (-3.4A)
M77  A 601 (-4.5A)
M77  A 601 ( 3.5A)
M77  A 601 ( 4.7A)
M77  A 601 ( 2.9A)
M77  A 601 (-4.6A)
M77  A 601 ( 3.5A)
 1.20A 5yu9B-5vefA:
22.7		 5yu9B-5vefA:
13.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 GLY A 892
VAL A 899
ALA A 917
LYS A 919
MET A 938
THR A1027
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.94A 5yu9B-5wnoA:
34.6		 5yu9B-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 GLY A 892
VAL A 899
ALA A 917
MET A 938
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.77A 5yu9B-5wnoA:
34.6		 5yu9B-5wnoA:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 6 GLY A  76
VAL A  83
ALA A  95
LYS A  97
LEU A 139
LEU A 206
 ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-3.2A)
ANP  A1000 (-2.8A)
None
ANP  A1000 (-4.5A)
 0.70A 5yu9B-5xd6A:
23.9		 5yu9B-5xd6A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 6 GLY A  76
VAL A  83
LYS A  97
LEU A 139
ASP A 151
LEU A 206
 ANP  A1000 ( 3.8A)
ANP  A1000 (-4.1A)
ANP  A1000 (-2.8A)
None
ANP  A1000 ( 4.9A)
ANP  A1000 (-4.5A)
 0.59A 5yu9B-5xd6A:
23.9		 5yu9B-5xd6A:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 6 GLY A 205
VAL A 212
ALA A 225
LEU A 326
THR A 338
ASP A 339
 None
 0.75A 5yu9B-5xzwA:
18.7		 5yu9B-5xzwA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 GLY A  34
VAL A  41
ALA A  54
LYS A  56
MET A  74
ASP A 164
 ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
MG  A 502 ( 3.1A)
 0.87A 5yu9B-6ao5A:
23.4		 5yu9B-6ao5A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 GLY A  34
VAL A  41
ALA A  54
LYS A  56
MET A  99
LEU A 153
ASP A 164
 ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
ANP  A 501 (-2.5A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
 0.75A 5yu9B-6ao5A:
23.4		 5yu9B-6ao5A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 GLY A 219
VAL A 226
ALA A 237
LEU A 286
LEU A 347
ASP A 358
 DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.60A 5yu9B-6bfnA:
22.9		 5yu9B-6bfnA:
29.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 6 VAL C 173
ALA C 191
LEU C 288
LEU C 341
THR C 356
ASP C 357
 None
 0.60A 5yu9B-6eqiC:
20.4		 5yu9B-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 GLY A 193
VAL A 200
ALA A 211
LEU A 260
ASP A 272
LEU A 318
 CJT  A 502 ( 3.9A)
CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
None
CJT  A 502 (-3.3A)
CJT  A 502 (-4.7A)
 0.60A 5yu9B-6f3dA:
22.4		 5yu9B-6f3dA:
26.14