SIMILAR PATTERNS OF AMINO ACIDS FOR 5YU9_A_1E8A1101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 212
VAL A 219
ALA A 230
LYS A 232
LEU A 278
LEU A 340
ASP A 351
 None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
 0.95A 5yu9A-1py5A:
24.4		 5yu9A-1py5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  78
GLY A  79
VAL A  86
ALA A  99
LYS A 101
LEU A 201
ASP A 212
 ATP  A 535 (-3.9A)
ATP  A 535 ( 3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
ATP  A 535 (-4.8A)
MG  A 536 (-3.3A)
 0.66A 5yu9A-1s9iA:
16.9		 5yu9A-1s9iA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 370
VAL A 377
ALA A 389
LYS A 391
LEU A 433
CYH A 442
LEU A 489
 None
 0.77A 5yu9A-1snxA:
24.1		 5yu9A-1snxA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
GLY A  19
VAL A  26
ALA A  39
LYS A  41
LEU A  89
LEU A 144
 ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
ATP  A 381 (-2.9A)
None
None
 0.73A 5yu9A-1ua2A:
22.1		 5yu9A-1ua2A:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 GLY A  11
VAL A  18
ALA A  30
LEU A  77
LEU A 132
ASP A 143
 None
 0.51A 5yu9A-1v0bA:
23.6		 5yu9A-1v0bA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
GLY A  16
VAL A  23
ALA A  36
LYS A  38
LEU A  82
 HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
 0.58A 5yu9A-1zltA:
20.3		 5yu9A-1zltA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
LEU A  82
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 1.05A 5yu9A-1zltA:
20.3		 5yu9A-1zltA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  87
 None
 0.67A 5yu9A-2bdwA:
20.5		 5yu9A-2bdwA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  19
GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
ADP  A 500 (-4.3A)
 0.58A 5yu9A-2f9gA:
21.1		 5yu9A-2f9gA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.65A 5yu9A-2h8hA:
32.7		 5yu9A-2h8hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
LEU A 393
ASP A 404
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-4.4A)
None
 0.86A 5yu9A-2hckA:
30.9		 5yu9A-2hckA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LYS A  52
LEU A  96
 J60  A1305 (-3.9A)
None
J60  A1305 (-4.8A)
J60  A1305 (-3.3A)
EDO  A1304 ( 2.9A)
None
 0.54A 5yu9A-2jamA:
16.1		 5yu9A-2jamA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  29
GLY A  30
VAL A  37
ALA A  50
LYS A  52
LEU A  96
 QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.6A)
QPP  A1314 ( 3.7A)
None
None
 0.57A 5yu9A-2jc6A:
20.3		 5yu9A-2jc6A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 LEU A 344
GLY A 345
VAL A 352
ALA A 367
LYS A 369
MET A 390
LEU A 412
LEU A 468
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.1A)
None
None
ANP  A 615 (-4.7A)
MG  A 614 ( 3.2A)
 0.82A 5yu9A-2ozoA:
30.5		 5yu9A-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 344
GLY A 345
VAL A 352
ALA A 367
MET A 390
MET A 414
ASP A 479
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
None
ANP  A 615 ( 3.9A)
MG  A 614 ( 3.2A)
 1.11A 5yu9A-2ozoA:
30.5		 5yu9A-2ozoA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 LEU A  25
GLY A  26
VAL A  33
ALA A  46
LEU A 101
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.70A 5yu9A-2phkA:
21.8		 5yu9A-2phkA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 GLY B  48
VAL B  55
ALA B  67
LYS B  69
LEU B 112
LEU B 171
THR B 181
 None
 0.85A 5yu9A-2qkwB:
22.1		 5yu9A-2qkwB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 725
VAL A 732
LYS A 751
LEU A 794
CYH A 803
THR A 860
ASP A 861
 None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-2.3A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.96A 5yu9A-2r4bA:
32.4		 5yu9A-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 724
GLY A 725
VAL A 732
ALA A 749
LYS A 751
LEU A 794
LEU A 850
THR A 860
ASP A 861
 GW7  A   1 ( 4.2A)
None
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
GW7  A   1 (-4.1A)
 0.72A 5yu9A-2r4bA:
32.4		 5yu9A-2r4bA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 226
GLY A 227
VAL A 234
ALA A 247
LYS A 249
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.5A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.81A 5yu9A-2xk9A:
15.8		 5yu9A-2xk9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  68
GLY A  69
VAL A  76
ALA A  92
LYS A  94
LEU A 139
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
 0.62A 5yu9A-2z7rA:
22.2		 5yu9A-2z7rA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  24
VAL A  31
ALA A  44
LYS A  46
MET A  67
LEU A  90
LEU A 153
ASP A 164
 ANP  A   1 (-3.3A)
ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
ANP  A   1 (-2.8A)
None
None
None
ANP  A   1 (-3.8A)
 0.79A 5yu9A-3dakA:
22.7		 5yu9A-3dakA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 151
VAL A 158
ALA A 169
LEU A 218
LEU A 275
THR A 293
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 (-4.5A)
VIN  A6331 (-3.6A)
 0.62A 5yu9A-3dtcA:
27.7		 5yu9A-3dtcA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A 118
 985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
None
 0.53A 5yu9A-3f2aA:
16.0		 5yu9A-3f2aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		6 LEU A  21
VAL A  29
ALA A  42
LEU A  89
LEU A 143
ASP A 159
 None
 0.56A 5yu9A-3gbzA:
24.1		 5yu9A-3gbzA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		7 LEU A 226
GLY A 227
VAL A 234
ALA A 247
LEU A 354
THR A 367
ASP A 368
 None
 0.72A 5yu9A-3i6uA:
21.9		 5yu9A-3i6uA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 696
GLY A 697
VAL A 704
LYS A 723
LEU A 766
LEU A 822
ASP A 833
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.7A)
ANP  A   1 (-3.9A)
ANP  A   1 (-3.4A)
None
ANP  A   1 (-4.7A)
MG  A1001 ( 3.1A)
 0.60A 5yu9A-3kexA:
35.4		 5yu9A-3kexA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  68
GLY A  69
VAL A  76
ALA A  89
LYS A  91
LEU A 136
LEU A 191
 ANP  A 522 (-4.6A)
ANP  A 522 (-3.5A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.6A)
ANP  A 522 (-3.5A)
None
ANP  A 522 (-4.7A)
 0.78A 5yu9A-3lijA:
22.6		 5yu9A-3lijA:
9.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 694
GLY A 695
VAL A 702
ALA A 719
LYS A 721
MET A 742
LEU A 764
CYH A 773
THR A 830
ASP A 831
 ITI  A   1 (-3.9A)
ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-2.6A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
 0.79A 5yu9A-3lzbA:
39.0		 5yu9A-3lzbA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 694
GLY A 695
VAL A 702
ALA A 719
MET A 742
LEU A 764
CYH A 773
LEU A 820
THR A 830
ASP A 831
 ITI  A   1 (-3.9A)
ITI  A   1 ( 4.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.4A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-4.8A)
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
ITI  A   1 ( 4.6A)
 0.76A 5yu9A-3lzbA:
39.0		 5yu9A-3lzbA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LYS A 215
LEU A 261
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 (-4.8A)
 0.78A 5yu9A-3nyoA:
20.8		 5yu9A-3nyoA:
9.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 727
VAL A 734
ALA A 751
LEU A 796
CYH A 805
LEU A 852
THR A 862
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.58A 5yu9A-3pp0A:
34.6		 5yu9A-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LEU A 796
CYH A 805
LEU A 852
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-4.4A)
 0.64A 5yu9A-3pp0A:
34.6		 5yu9A-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
GLY A 727
VAL A 734
ALA A 751
LYS A 753
LEU A 796
 03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
 0.65A 5yu9A-3pp0A:
34.6		 5yu9A-3pp0A:
59.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 734
ALA A 751
LEU A 796
CYH A 805
LEU A 852
THR A 862
ASP A 863
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.3A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
03Q  A   1 (-4.0A)
 0.85A 5yu9A-3pp0A:
34.6		 5yu9A-3pp0A:
59.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  63
GLY A  64
VAL A  71
ALA A  84
LYS A  86
LEU A 142
 ANP  A1634 ( 4.3A)
ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
 0.58A 5yu9A-3q5iA:
21.7		 5yu9A-3q5iA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  57
GLY A  58
VAL A  65
ALA A  78
LYS A  80
LEU A 126
LEU A 181
ASP A 195
 BK5  A 701 ( 4.2A)
BK5  A 701 ( 3.8A)
BK5  A 701 (-4.2A)
BK5  A 701 (-3.4A)
BK5  A 701 (-3.5A)
BK5  A 701 (-3.3A)
None
BK5  A 701 (-4.0A)
 0.81A 5yu9A-3sxfA:
23.3		 5yu9A-3sxfA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 423
GLY A 424
VAL A 431
ALA A 443
LYS A 445
CYH A 496
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
None
PP2  A   1 (-4.6A)
 0.81A 5yu9A-3sxsA:
28.9		 5yu9A-3sxsA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 LEU A 295
GLY A 296
VAL A 303
ALA A 315
LYS A 317
LEU A 361
LEU A 423
ASP A 434
 None
 0.93A 5yu9A-3ulzA:
21.5		 5yu9A-3ulzA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
GLY A  60
ALA A  80
LYS A  82
MET A 129
LEU A 186
ASP A 197
 None
ANK  A 401 (-3.4A)
ANK  A 401 (-3.0A)
ANK  A 401 (-2.4A)
ANK  A 401 (-3.7A)
ANK  A 401 ( 4.9A)
MG  A 402 ( 2.8A)
 0.96A 5yu9A-3vn9A:
24.0		 5yu9A-3vn9A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
GLY A  60
VAL A  67
ALA A  80
MET A 129
LEU A 186
ASP A 197
 None
ANK  A 401 (-3.4A)
ANK  A 401 (-4.3A)
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
ANK  A 401 ( 4.9A)
MG  A 402 ( 2.8A)
 0.80A 5yu9A-3vn9A:
24.0		 5yu9A-3vn9A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  75
GLY A  76
VAL A  83
ALA A  96
LYS A  98
MET A 144
LEU A 198
ASP A 209
 ANP  A 401 (-3.8A)
ANP  A 401 ( 3.7A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
ANP  A 401 (-4.8A)
MG  A 402 (-3.2A)
 0.83A 5yu9A-3wigA:
23.4		 5yu9A-3wigA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  83
GLY A  84
VAL A  91
ALA A 104
LYS A 106
LEU A 152
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-4.6A)
 0.93A 5yu9A-4af3A:
19.0		 5yu9A-4af3A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  11
VAL A  18
ALA A  31
LYS A  33
LEU A  78
LEU A 133
 D15  A 500 (-3.8A)
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.5A)
 0.60A 5yu9A-4aguA:
22.2		 5yu9A-4aguA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  42
GLY A  43
VAL A  50
ALA A  63
LEU A 164
ASP A 175
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.9A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.7A)
XZN  A1317 (-3.2A)
 0.64A 5yu9A-4bc6A:
20.4		 5yu9A-4bc6A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 GLY A 215
VAL A 222
ALA A 233
LYS A 235
LEU A 281
LEU A 343
ASP A 354
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.5A)
 0.85A 5yu9A-4c02A:
24.7		 5yu9A-4c02A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
GLY A 247
VAL A 254
ALA A 267
LEU A 371
THR A 381
ASP A 382
 None
 0.89A 5yu9A-4c0tA:
20.4		 5yu9A-4c0tA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		7 GLY A  18
VAL A  24
ALA A  37
LYS A  39
LEU A  85
MET A  87
ASP A 151
 ANP  A 300 ( 3.7A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.1A)
None
ANP  A 300 (-3.6A)
None
 1.17A 5yu9A-4eqmA:
23.3		 5yu9A-4eqmA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		8 LEU A  16
GLY A  17
VAL A  24
ALA A  37
LYS A  39
LEU A  85
MET A  87
ASP A 151
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.4A)
ANP  A 300 ( 4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.1A)
None
ANP  A 300 (-3.6A)
None
 0.91A 5yu9A-4eqmA:
23.3		 5yu9A-4eqmA:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
LEU A 446
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.92A 5yu9A-4f4pA:
25.5		 5yu9A-4f4pA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 448
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
0SB  A 701 (-3.6A)
0SB  A 701 (-3.9A)
 1.07A 5yu9A-4f4pA:
25.5		 5yu9A-4f4pA:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  93
 ATP  A 401 (-3.8A)
ATP  A 401 ( 3.7A)
ATP  A 401 (-4.1A)
ATP  A 401 (-3.6A)
ATP  A 401 (-3.0A)
None
 0.61A 5yu9A-4fg8A:
22.4		 5yu9A-4fg8A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 424
LEU A 446
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
None
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.59A 5yu9A-4fl3A:
31.4		 5yu9A-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		8 LEU A 377
GLY A 378
VAL A 385
ALA A 400
LYS A 402
MET A 448
LEU A 501
ASP A 512
 ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
 0.79A 5yu9A-4fl3A:
31.4		 5yu9A-4fl3A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
MET A 181
LEU A 259
ASP A 270
 None
 0.81A 5yu9A-4hzsA:
31.0		 5yu9A-4hzsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
GLY A 133
VAL A 140
ALA A 156
LYS A 158
MET A 181
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.0A)
1G0  A 401 (-4.6A)
 1.47A 5yu9A-4id7A:
29.4		 5yu9A-4id7A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		8 LEU A 258
GLY A 259
VAL A 266
ALA A 279
LYS A 281
LEU A 354
MET A 356
LEU A 416
 ANP  A 601 ( 4.6A)
ANP  A 601 (-3.4A)
ANP  A 601 (-4.1A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.2A)
None
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
 0.92A 5yu9A-4jrnA:
18.7		 5yu9A-4jrnA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
MET A 314
LEU A 393
ASP A 404
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
 0.60A 5yu9A-4k11A:
33.0		 5yu9A-4k11A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
GLY A 274
VAL A 281
ALA A 293
LYS A 295
LEU A 393
ASP A 404
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.7A)
 0.85A 5yu9A-4lggA:
28.1		 5yu9A-4lggA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  29
VAL A  36
ALA A  49
LYS A  51
LEU A  93
LEU A 150
ASP A 161
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-4.8A)
MG  A 403 ( 3.1A)
 0.64A 5yu9A-4m69A:
26.5		 5yu9A-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY A  29
VAL A  36
ALA A  49
LYS A  51
MET A  65
LEU A  93
LEU A 150
 ANP  A 401 (-3.8A)
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
None
ANP  A 401 (-4.8A)
 0.96A 5yu9A-4m69A:
26.5		 5yu9A-4m69A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 386
GLY A 387
VAL A 394
ALA A 407
LEU A 511
ASP A 522
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
 0.49A 5yu9A-4q9zA:
20.2		 5yu9A-4q9zA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  76
GLY A  77
VAL A  84
ALA A  97
LYS A  99
LEU A 145
ASP A 215
 None
 0.43A 5yu9A-4rgjA:
22.9		 5yu9A-4rgjA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
GLY A 617
VAL A 624
ALA A 642
LYS A 644
LEU A 689
LEU A 818
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
 0.89A 5yu9A-4rt7A:
24.1		 5yu9A-4rt7A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
GLY A 193
VAL A 200
ALA A 213
LEU A 261
LEU A 318
ASP A 329
 SGV  A 601 (-4.1A)
SGV  A 601 (-3.4A)
SGV  A 601 ( 4.6A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
SGV  A 601 (-3.0A)
 0.82A 5yu9A-4tnbA:
19.5		 5yu9A-4tnbA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
GLY A  15
VAL A  22
ALA A  35
LYS A  37
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.8A)
 0.65A 5yu9A-4ueuA:
28.3		 5yu9A-4ueuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 262
LEU A 321
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 (-4.9A)
 0.70A 5yu9A-4wboA:
21.2		 5yu9A-4wboA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 408
GLY A 409
VAL A 416
ALA A 428
MET A 449
CYH A 481
LEU A 528
ASP A 539
 None
 0.98A 5yu9A-4xi2A:
29.9		 5yu9A-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
GLY A 409
VAL A 416
LYS A 430
MET A 449
CYH A 481
ASP A 539
 None
 1.09A 5yu9A-4xi2A:
29.9		 5yu9A-4xi2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
GLY A 409
VAL A 416
ALA A 428
CYH A 481
LEU A 528
ASP A 539
 746  A 702 (-3.8A)
746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
746  A 702 (-3.7A)
 0.71A 5yu9A-4y93A:
30.2		 5yu9A-4y93A:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  11
VAL A  18
ALA A  31
LYS A  33
LEU A  78
LEU A 135
ASP A 146
 None
 0.68A 5yu9A-4yc6A:
23.5		 5yu9A-4yc6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
GLY A 194
VAL A 201
ALA A 214
LYS A 216
LEU A 262
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
AN2  A 601 ( 3.9A)
None
None
 0.87A 5yu9A-4yhjA:
19.6		 5yu9A-4yhjA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  80
ASP A 160
 None
 1.45A 5yu9A-4ynzA:
21.1		 5yu9A-4ynzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		8 LEU A  26
GLY A  27
VAL A  34
ALA A  47
LYS A  49
LEU A  94
LEU A 149
ASP A 160
 None
 0.68A 5yu9A-4ynzA:
21.1		 5yu9A-4ynzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 577
GLY A 578
VAL A 586
ALA A 597
LYS A 599
LEU A 695
ASP A 711
 None
 1.11A 5yu9A-4z7gA:
18.6		 5yu9A-4z7gA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLY A 485
VAL A 492
ALA A 512
LYS A 514
LEU A 630
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
 0.95A 5yu9A-5a46A:
25.5		 5yu9A-5a46A:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A  82
VAL A  89
ALA A 102
LYS A 104
LEU A 148
LEU A 211
 ANP  A 401 ( 3.9A)
ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
ANP  A 401 (-3.0A)
None
None
 0.63A 5yu9A-5dbxA:
22.0		 5yu9A-5dbxA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 251
VAL A 258
ALA A 275
LYS A 277
LEU A 323
LEU A 386
 STU  A 601 (-2.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
None
STU  A 601 (-3.9A)
 0.63A 5yu9A-5e8yA:
18.3		 5yu9A-5e8yA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		7 LEU A  99
GLY A 100
VAL A 107
ALA A 120
LYS A 122
LEU A 168
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-4.7A)
 0.74A 5yu9A-5eykA:
21.9		 5yu9A-5eykA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 802
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PP1  A2012 (-4.6A)
 0.51A 5yu9A-5fm2A:
28.6		 5yu9A-5fm2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  28
VAL A  35
ALA A  50
LYS A  52
LEU A  95
LEU A 158
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
None
6A7  A 401 (-4.8A)
 0.66A 5yu9A-5idnA:
16.1		 5yu9A-5idnA:
12.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 718
GLY A 719
VAL A 726
ALA A 743
LEU A 788
MET A 790
CYH A 797
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.55A 5yu9A-5j9zA:
35.4		 5yu9A-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 718
GLY A 719
VAL A 726
ALA A 743
LYS A 745
LEU A 788
MET A 790
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.4A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.68A 5yu9A-5j9zA:
35.4		 5yu9A-5j9zA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 718
GLY A 719
VAL A 726
ALA A 743
MET A 790
CYH A 797
LEU A 844
THR A 854
ASP A 855
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-3.4A)
6HJ  A1101 (-1.6A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
 0.78A 5yu9A-5j9zA:
35.4		 5yu9A-5j9zA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A 277
VAL A 284
ALA A 297
LYS A 299
LEU A 396
THR A 406
 IPW  A 601 ( 3.9A)
IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.53A 5yu9A-5kbrA:
21.6		 5yu9A-5kbrA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 GLY A 890
VAL A 897
ALA A 909
LYS A 911
LEU A 954
LEU A1016
ASP A1027
 ATP  A1200 ( 4.6A)
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 0.89A 5yu9A-5lpyA:
22.1		 5yu9A-5lpyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 GLY A 890
VAL A 897
ALA A 909
LYS A 911
LEU A 954
LEU A1016
ASP A1027
 ADP  A1200 ( 4.0A)
ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
 0.98A 5yu9A-5lpzA:
21.9		 5yu9A-5lpzA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m09 SERINE/THREONINE-PRO
TEIN KINASE PKNI

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		7 LEU A  18
GLY A  19
VAL A  26
ALA A  39
LYS A  41
MET A  89
ASP A 159
 None
 0.78A 5yu9A-5m09A:
16.9		 5yu9A-5m09A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 6 LEU A  44
GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A 118
 None
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
None
 0.56A 5yu9A-5turA:
21.7		 5yu9A-5turA:
11.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 GLY A 892
VAL A 899
ALA A 917
LYS A 919
MET A 938
THR A1027
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.91A 5yu9A-5wnoA:
34.5		 5yu9A-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 GLY A 892
VAL A 899
ALA A 917
MET A 938
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
None
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.77A 5yu9A-5wnoA:
34.5		 5yu9A-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LEU A1017
THR A1027
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.64A 5yu9A-5wnoA:
34.5		 5yu9A-5wnoA:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A1027
ASP A1028
 ANP  A1201 (-4.1A)
ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 ( 4.9A)
MG  A1202 ( 3.0A)
 0.77A 5yu9A-5wnoA:
34.5		 5yu9A-5wnoA:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 8 LEU A  33
GLY A  34
VAL A  41
ALA A  54
LYS A  56
MET A  99
LEU A 153
ASP A 164
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.9A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
ANP  A 501 (-2.5A)
ANP  A 501 (-4.6A)
MG  A 502 ( 3.1A)
 0.74A 5yu9A-6ao5A:
23.6		 5yu9A-6ao5A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 6 GLY A 219
VAL A 226
ALA A 237
LEU A 286
LEU A 347
ASP A 358
 DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.4A)
None
DL1  A 601 (-3.9A)
DL1  A 601 (-3.1A)
 0.63A 5yu9A-6bfnA:
22.9		 5yu9A-6bfnA:
29.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
GLY A 882
VAL A 889
ALA A 906
LYS A 908
MET A 956
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
ADP  A1201 (-4.2A)
ADP  A1201 (-4.5A)
 1.05A 5yu9A-6c7yA:
28.6		 5yu9A-6c7yA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 6 GLY A 135
VAL A 142
ALA A 155
LYS A 157
LEU A 228
LEU A 282
 H1N  A 501 ( 3.8A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
None
H1N  A 501 (-4.8A)
 0.66A 5yu9A-6ccfA:
22.3		 5yu9A-6ccfA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqi SERINE/THREONINE-PRO
TEIN KINASE PINK1,
PUTATIVE

(Pediculus
humanus) 		no annotation 6 VAL C 173
ALA C 191
LEU C 288
LEU C 341
THR C 356
ASP C 357
 None
 0.62A 5yu9A-6eqiC:
20.1		 5yu9A-6eqiC:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LEU U  20
GLY U  21
VAL U  28
ALA U  42
LEU U  89
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
None
DB8  U 301 (-4.8A)
 0.58A 5yu9A-6fdyU:
20.0		 5yu9A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 LEU A 730
GLY A 731
VAL A 738
ALA A 756
LEU A 802
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 (-4.3A)
 0.55A 5yu9A-6fekA:
28.4		 5yu9A-6fekA:
30.00