SIMILAR PATTERNS OF AMINO ACIDS FOR 5YSI_A_NCAA1001_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE


(Leishmania
mexicana)
PF00274
(Glycolytic)
4 GLY A 235
SER A  23
THR A  28
VAL A 193
None
0.98A 5ysiA-1epxA:
0.0
5ysiA-1epxA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9z PHOSPHATIDYLINOSITOL
PHOSPHATE
PHOSPHATASE


(Schizosaccharomyces
pombe)
PF03372
(Exo_endo_phos)
4 ARG A 614
GLY A 641
THR A 646
VAL A 682
None
0.85A 5ysiA-1i9zA:
0.0
5ysiA-1i9zA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE


(Clostridium
beijerinckii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLY A1058
SER A1039
THR A1043
TRP A1110
None
ZN  A1353 ( 3.7A)
None
None
1.10A 5ysiA-1jqbA:
0.0
5ysiA-1jqbA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens)
PF01442
(Apolipoprotein)
4 GLY A 165
SER A  94
THR A  89
VAL A  85
None
0.94A 5ysiA-1lpeA:
0.0
5ysiA-1lpeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mmf GLYCEROL DEHYDRASE
BETA SUBUNIT


(Klebsiella
pneumoniae)
PF02288
(Dehydratase_MU)
4 GLY B  98
SER B 101
THR B 104
VAL B  80
None
None
B12  B 601 (-3.0A)
None
1.21A 5ysiA-1mmfB:
0.0
5ysiA-1mmfB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uez KIAA1526 PROTEIN

(Homo sapiens)
PF00595
(PDZ)
4 ARG A  54
GLY A  52
SER A  91
VAL A  12
None
1.07A 5ysiA-1uezA:
0.0
5ysiA-1uezA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcm DNA-DIRECTED RNA
POLYMERASE II 32 KDA
POLYPEPTIDE


(Saccharomyces
cerevisiae)
PF03874
(RNA_pol_Rpb4)
4 ARG D 153
GLY D 181
SER D 215
VAL D 163
None
1.13A 5ysiA-1wcmD:
0.0
5ysiA-1wcmD:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE


(Thermoplasma
acidophilum)
PF00561
(Abhydrolase_1)
4 GLY A 129
SER A 132
THR A 137
VAL A 246
None
None
PHE  A 300 (-3.9A)
None
1.21A 5ysiA-1xqwA:
0.0
5ysiA-1xqwA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yox HYPOTHETICAL PROTEIN
PA3696


(Pseudomonas
aeruginosa)
PF01987
(AIM24)
4 ARG A 109
GLY A 108
THR A 184
VAL A 106
None
0.99A 5ysiA-1yoxA:
0.0
5ysiA-1yoxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq9 PERIPLASMIC [NIFE]
HYDROGENASE SMALL
SUBUNIT


(Desulfovibrio
gigas)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
4 ARG A  26
SER A  23
THR A  27
VAL A  32
None
1.22A 5ysiA-1yq9A:
undetectable
5ysiA-1yq9A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy8 DIHYDROLIPOYL
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A 201
SER A  60
VAL A 177
TRP A 197
None
1.17A 5ysiA-1zy8A:
undetectable
5ysiA-1zy8A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3g ALPHA-AMYLASE G-6

(Bacillus
halodurans)
PF16738
(CBM26)
4 GLY A  56
SER A  59
THR A  27
VAL A  31
None
1.24A 5ysiA-2c3gA:
undetectable
5ysiA-2c3gA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE


(Anopheles
gambiae)
PF00266
(Aminotran_5)
4 ARG A 356
GLY A  23
SER A 154
THR A 316
GOL  A1391 (-3.1A)
None
PLP  A1390 ( 2.4A)
None
1.20A 5ysiA-2ch1A:
undetectable
5ysiA-2ch1A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3l GLUCAN
1,4-ALPHA-MALTOHEXAO
SIDASE


(Bacillus sp.
707)
PF00128
(Alpha-amylase)
PF09154
(DUF1939)
4 GLY A 470
THR A 414
VAL A 442
TRP A 451
None
1.22A 5ysiA-2d3lA:
undetectable
5ysiA-2d3lA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dgk GLUTAMATE
DECARBOXYLASE BETA


(Escherichia
coli)
PF00282
(Pyridoxal_deC)
4 GLY A 133
SER A 127
THR A 123
VAL A 287
None
PLP  A1500 (-2.6A)
None
None
1.06A 5ysiA-2dgkA:
undetectable
5ysiA-2dgkA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkn 3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE


(Pseudomonas sp.
B-0831)
PF13561
(adh_short_C2)
4 ARG A 213
GLY A 212
SER A 215
VAL A 208
None
0.74A 5ysiA-2dknA:
undetectable
5ysiA-2dknA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hes YDR267CP

(Saccharomyces
cerevisiae)
PF00400
(WD40)
4 GLY X  76
SER X 126
THR X 124
VAL X  82
None
1.08A 5ysiA-2hesX:
undetectable
5ysiA-2hesX:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hes YDR267CP

(Saccharomyces
cerevisiae)
PF00400
(WD40)
4 GLY X 315
SER X  31
THR X  29
VAL X 321
None
1.02A 5ysiA-2hesX:
undetectable
5ysiA-2hesX:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hma PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE


(Streptococcus
pneumoniae)
PF03054
(tRNA_Me_trans)
4 GLY A  35
SER A  20
THR A  22
VAL A  11
None
1.17A 5ysiA-2hmaA:
undetectable
5ysiA-2hmaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huf ALANINE GLYOXYLATE
AMINOTRANSFERASE


(Aedes aegypti)
PF00266
(Aminotran_5)
4 ARG A 356
GLY A  24
SER A 155
THR A 316
1BO  A 602 (-3.0A)
None
LLP  A 206 (-2.8A)
None
1.13A 5ysiA-2hufA:
undetectable
5ysiA-2hufA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nqw CBS DOMAIN PROTEIN

(Porphyromonas
gingivalis)
PF03471
(CorC_HlyC)
4 GLY A  40
SER A  23
THR A  45
VAL A  43
None
0.98A 5ysiA-2nqwA:
undetectable
5ysiA-2nqwA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE


(Streptomyces)
PF01494
(FAD_binding_3)
4 GLY A  45
SER A  41
THR A  98
VAL A  94
None
1.12A 5ysiA-2qa2A:
undetectable
5ysiA-2qa2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvb HALOALKANE
DEHALOGENASE 3


(Mycobacterium
tuberculosis)
PF00561
(Abhydrolase_1)
4 ARG A 210
GLY A 160
SER A 207
THR A 205
None
1.24A 5ysiA-2qvbA:
undetectable
5ysiA-2qvbA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cer POSSIBLE
EXOPOLYPHOSPHATASE-L
IKE PROTEIN


(Bifidobacterium
longum)
PF02541
(Ppx-GppA)
4 GLY A 295
SER A 232
THR A 237
VAL A 292
None
SO4  A 345 ( 3.4A)
None
None
1.20A 5ysiA-3cerA:
undetectable
5ysiA-3cerA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cim CARBON
DIOXIDE-CONCENTRATIN
G MECHANISM PROTEIN
CCMK HOMOLOG 2


(Synechocystis
sp.)
PF00936
(BMC)
4 ARG A  11
GLY A  40
THR A  10
VAL A  42
GOL  A 101 (-3.0A)
None
None
None
1.11A 5ysiA-3cimA:
undetectable
5ysiA-3cimA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7o SERINE PROTEASE

(Purpureocillium
lilacinum)
PF00082
(Peptidase_S8)
4 ARG A 192
GLY A 267
SER A 194
THR A 187
None
1.00A 5ysiA-3f7oA:
undetectable
5ysiA-3f7oA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2


(Mus musculus)
PF04916
(Phospholip_B)
4 ARG A 485
GLY A 556
THR A 268
TRP A 103
None
1.11A 5ysiA-3fgwA:
undetectable
5ysiA-3fgwA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE


(Medicago
truncatula)
PF00201
(UDPGT)
4 GLY A 354
THR A 384
VAL A 358
TRP A 355
UDP  A 900 (-3.5A)
None
None
None
1.07A 5ysiA-3hbjA:
undetectable
5ysiA-3hbjA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN


(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
4 ARG A  76
THR A  68
VAL A 106
TRP A 163
None
1.22A 5ysiA-3hdxA:
undetectable
5ysiA-3hdxA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120)
PF02374
(ArsA_ATPase)
4 ARG A  15
SER A  11
THR A 221
VAL A 231
None
0.97A 5ysiA-3igfA:
undetectable
5ysiA-3igfA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11


(Schizosaccharomyces
pombe)
PF13087
(AAA_12)
PF16399
(Aquarius_N)
4 ARG X 357
SER X 249
THR X 253
VAL X 376
None
1.20A 5ysiA-3jb9X:
undetectable
5ysiA-3jb9X:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgw ALANINE-GLYOXYLATE
AMINOTRANSFERASE


(Mus musculus)
PF00266
(Aminotran_5)
4 ARG A 382
GLY A  49
SER A 180
THR A 342
None
None
PLP  A 500 (-2.6A)
None
1.17A 5ysiA-3kgwA:
undetectable
5ysiA-3kgwA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A 203
SER A  63
VAL A 179
TRP A 199
None
1.00A 5ysiA-3ladA:
undetectable
5ysiA-3ladA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc6 SPHINGOSINE-1-PHOSPH
ATE LYASE


(Saccharomyces
cerevisiae)
PF00282
(Pyridoxal_deC)
4 ARG C 517
GLY C 176
THR C 516
VAL C 173
None
1.17A 5ysiA-3mc6C:
undetectable
5ysiA-3mc6C:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF04053
(Coatomer_WDAD)
4 GLY A 159
SER A 205
THR A 203
VAL A 165
None
1.14A 5ysiA-3mkqA:
undetectable
5ysiA-3mkqA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwe ATP-CITRATE SYNTHASE

(Homo sapiens)
PF16114
(Citrate_bind)
4 ARG A 379
GLY A 381
SER A 343
THR A 407
TLA  A 427 (-2.9A)
None
TLA  A 427 ( 4.2A)
None
1.21A 5ysiA-3mweA:
undetectable
5ysiA-3mweA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica)
PF00390
(malic)
PF03949
(Malic_M)
4 ARG A 101
GLY A 106
SER A 171
VAL A 108
GOL  A 498 (-4.8A)
None
None
None
1.06A 5ysiA-3nv9A:
undetectable
5ysiA-3nv9A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE


(Thermotoga
maritima)
PF00701
(DHDPS)
4 GLY A 202
SER A 175
THR A 177
VAL A 186
None
1.16A 5ysiA-3pb0A:
undetectable
5ysiA-3pb0A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfe PLATELET
GLYCOPROTEIN IB BETA
CHAIN


(Homo sapiens)
PF01463
(LRRCT)
4 ARG A  17
GLY A  15
SER A   6
VAL A  36
None
1.23A 5ysiA-3rfeA:
undetectable
5ysiA-3rfeA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssq CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN


(Thermosynechococcus
elongatus)
PF00936
(BMC)
4 ARG A  11
GLY A  40
THR A  10
VAL A  42
None
1.06A 5ysiA-3ssqA:
undetectable
5ysiA-3ssqA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twc PGT127 HEAVY CHAIN,
IG GAMMA-1 CHAIN C
REGION


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 GLY H  35
SER H  52
THR H  29
VAL H  78
None
1.16A 5ysiA-3twcH:
undetectable
5ysiA-3twcH:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1


(Pseudomonas
syringae group
genomosp. 3)
no annotation 4 ARG B 164
GLY B 165
SER B 193
THR B 195
None
0.83A 5ysiA-3u0jB:
9.6
5ysiA-3u0jB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upg OUTER MEMBRANE
PROTEIN C


(Salmonella
enterica)
PF00267
(Porin_1)
4 GLY A 212
SER A 177
THR A 169
VAL A 100
None
0.93A 5ysiA-3upgA:
undetectable
5ysiA-3upgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A 198
SER A  56
VAL A 174
TRP A 194
None
1.04A 5ysiA-3urhA:
undetectable
5ysiA-3urhA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uw2 PHOSPHOGLUCOMUTASE/P
HOSPHOMANNOMUTASE
FAMILY PROTEIN


(Burkholderia
thailandensis)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 ARG A  51
GLY A  50
SER A 109
VAL A 184
None
EDO  A 466 (-3.9A)
PO4  A 465 ( 1.6A)
None
1.17A 5ysiA-3uw2A:
undetectable
5ysiA-3uw2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brz HALOALKANE
DEHALOGENASE


(Rhodobacteraceae)
PF00561
(Abhydrolase_1)
4 ARG A 208
GLY A 158
THR A 203
VAL A 162
None
1.21A 5ysiA-4brzA:
undetectable
5ysiA-4brzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans)
PF00199
(Catalase)
PF06628
(Catalase-rel)
4 ARG A 374
GLY A 378
SER A 370
THR A 372
CL  A1537 (-3.4A)
None
None
HEM  A 537 (-3.7A)
0.95A 5ysiA-4cabA:
undetectable
5ysiA-4cabA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d25 BMVLG PROTEIN

(Bombyx mori)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 GLY A 400
SER A 373
THR A 226
VAL A 516
None
None
ANP  A1564 (-4.5A)
None
1.21A 5ysiA-4d25A:
undetectable
5ysiA-4d25A:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2


(Cryptococcus
neoformans)
PF00400
(WD40)
4 GLY A 301
SER A  35
THR A  33
VAL A 307
None
1.13A 5ysiA-4d6vA:
undetectable
5ysiA-4d6vA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus)
PF00082
(Peptidase_S8)
4 ARG A 185
GLY A 262
SER A 187
THR A 180
None
1.01A 5ysiA-4dztA:
undetectable
5ysiA-4dztA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0q COP9 SIGNALOSOME
COMPLEX SUBUNIT 6


(Drosophila
melanogaster)
PF01398
(JAB)
4 ARG A  92
GLY A  91
SER A  51
THR A  53
None
1.22A 5ysiA-4e0qA:
undetectable
5ysiA-4e0qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo1 LINCOSAMIDE
RESISTANCE PROTEIN


(Staphylococcus
haemolyticus)
PF10706
(Aminoglyc_resit)
4 GLY A  32
SER A 133
THR A 122
VAL A  35
None
1.12A 5ysiA-4fo1A:
undetectable
5ysiA-4fo1A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE


(Granulibacter
bethesdensis)
PF01425
(Amidase)
4 GLY A 217
SER A 164
THR A 208
VAL A 185
None
0.93A 5ysiA-4gysA:
undetectable
5ysiA-4gysA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hs4 CHROMATE REDUCTASE

(Komagataeibacter
hansenii)
PF03358
(FMN_red)
4 GLY A  90
SER A  15
THR A  81
VAL A  88
None
1.08A 5ysiA-4hs4A:
undetectable
5ysiA-4hs4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga)
no annotation 4 GLY B 448
SER B 452
THR B 454
VAL B 460
None
1.17A 5ysiA-4iglB:
undetectable
5ysiA-4iglB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE


(Kluyveromyces
lactis)
PF01425
(Amidase)
4 GLY A 129
SER A 135
THR A 133
VAL A 131
TAR  A 701 (-3.7A)
None
None
None
1.24A 5ysiA-4issA:
undetectable
5ysiA-4issA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2


(Homo sapiens)
PF00400
(WD40)
4 GLY A 341
SER A 395
THR A 393
VAL A 347
None
1.08A 5ysiA-4j0wA:
undetectable
5ysiA-4j0wA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j73 COATOMER SUBUNIT
BETA'


(Saccharomyces
cerevisiae)
PF00400
(WD40)
4 GLY A 159
SER A 205
THR A 203
VAL A 165
None
1.18A 5ysiA-4j73A:
undetectable
5ysiA-4j73A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jj9 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE


(Bordetella
bronchiseptica)
PF02962
(CHMI)
4 ARG A  87
GLY A  84
SER A  88
VAL A 124
None
1.22A 5ysiA-4jj9A:
undetectable
5ysiA-4jj9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE


(Agrobacterium
vitis)
PF05544
(Pro_racemase)
4 GLY B  19
SER B  94
THR B  99
VAL B  12
None
1.24A 5ysiA-4k7gB:
undetectable
5ysiA-4k7gB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt3 PUTATIVE LIPOPROTEIN

(Pseudomonas
protegens)
no annotation 4 GLY B 109
SER B 139
THR B 136
VAL B 132
None
1.18A 5ysiA-4kt3B:
undetectable
5ysiA-4kt3B:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9o SEC16,PROTEIN
TRANSPORT PROTEIN
SEC13


(Komagataella
pastoris;
Komagataella
phaffii)
PF00400
(WD40)
4 GLY A2179
SER A2229
THR A2227
VAL A2185
None
1.18A 5ysiA-4l9oA:
undetectable
5ysiA-4l9oA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mow GLUCOSE
1-DEHYDROGENASE


(Burkholderia
cenocepacia)
PF13561
(adh_short_C2)
4 ARG A 214
GLY A 216
THR A 192
VAL A 188
None
1.04A 5ysiA-4mowA:
undetectable
5ysiA-4mowA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofl EXTRACYTOPLASMIC
NICKEL-BINDING
PROTEIN YPYNTA


(Yersinia pestis)
PF00496
(SBP_bac_5)
4 GLY A 367
THR A 381
VAL A 372
TRP A 369
None
None
None
HIS  A 502 (-3.3A)
0.96A 5ysiA-4oflA:
undetectable
5ysiA-4oflA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psw HISTONE
ACETYLTRANSFERASE
TYPE B SUBUNIT 2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
PF12265
(CAF1C_H4-bd)
4 GLY B 179
SER B 228
THR B 226
VAL B 185
None
1.17A 5ysiA-4pswB:
undetectable
5ysiA-4pswB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhy HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE


(Mycobacterium
tuberculosis)
PF00156
(Pribosyltran)
4 GLY A 194
SER A 191
THR A  29
VAL A  26
GLY  A 194 ( 0.0A)
SER  A 191 ( 0.0A)
THR  A  29 ( 0.8A)
VAL  A  26 ( 0.6A)
1.21A 5ysiA-4rhyA:
undetectable
5ysiA-4rhyA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 GLY A 301
SER A 114
THR A 207
VAL A 297
None
MG  A 400 (-2.4A)
None
None
1.15A 5ysiA-4utgA:
undetectable
5ysiA-4utgA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wdr HALOALKANE
DEHALOGENASE


(Sphingobium
japonicum)
PF00561
(Abhydrolase_1)
5 ARG A 209
GLY A 159
SER A 206
THR A 204
VAL A 163
None
1.34A 5ysiA-4wdrA:
undetectable
5ysiA-4wdrA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6k ANHYDROSIALIDASE

([Ruminococcus]
gnavus)
PF13088
(BNR_2)
4 GLY A 297
THR A 681
VAL A 269
TRP A 301
None
1.19A 5ysiA-4x6kA:
undetectable
5ysiA-4x6kA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y05 KINESIN-LIKE PROTEIN
KIF2C


(Homo sapiens)
PF00225
(Kinesin)
4 ARG A 258
GLY A 531
SER A 557
THR A 559
None
0.60A 5ysiA-4y05A:
undetectable
5ysiA-4y05A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0l PUTATIVE MEMBRANE
PROTEIN MMPL11


(Mycobacterium
tuberculosis)
no annotation 4 ARG A 496
GLY A 511
THR A 491
VAL A 425
None
1.13A 5ysiA-4y0lA:
undetectable
5ysiA-4y0lA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7p ALKALINE D-PEPTIDASE

(Bacillus cereus)
PF00144
(Beta-lactamase)
4 ARG A  71
SER A 215
THR A 143
VAL A 238
None
1.22A 5ysiA-4y7pA:
undetectable
5ysiA-4y7pA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoy SQT1

(Chaetomium
thermophilum)
PF00400
(WD40)
4 GLY A 210
SER A 259
THR A 257
VAL A 216
None
1.20A 5ysiA-4zoyA:
undetectable
5ysiA-4zoyA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv7 LIPASE B

(Moesziomyces
antarcticus)
no annotation 4 GLY A 307
SER A 161
THR A 310
VAL A 315
None
1.23A 5ysiA-4zv7A:
undetectable
5ysiA-4zv7A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3g M50

(Murid
betaherpesvirus
1)
PF04541
(Herpes_U34)
4 ARG A  83
GLY A  81
SER A  85
VAL A 110
None
1.16A 5ysiA-5a3gA:
undetectable
5ysiA-5a3gA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA


(Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 GLY A 428
SER A 414
THR A 419
VAL A 372
None
1.20A 5ysiA-5a8rA:
undetectable
5ysiA-5a8rA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG


(Cupriavidus
necator;
Cupriavidus
necator)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases)
4 ARG C 203
GLY A 277
THR C 209
VAL A 281
SF4  A 502 (-3.5A)
None
None
None
1.01A 5ysiA-5aa5C:
undetectable
5ysiA-5aa5C:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afo FIMBRIAE

(Escherichia
coli)
PF00419
(Fimbrial)
4 GLY A 128
SER A 154
THR A  69
VAL A  94
None
1.00A 5ysiA-5afoA:
undetectable
5ysiA-5afoA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c92 KELCH
DOMAIN-CONTAINING
PROTEIN


(Colletotrichum
graminicola)
PF01344
(Kelch_1)
PF09118
(DUF1929)
4 ARG A 118
GLY A 135
THR A 143
VAL A 164
None
1.24A 5ysiA-5c92A:
undetectable
5ysiA-5c92A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1)
PF00296
(Bac_luciferase)
4 ARG A  49
GLY A  48
SER A 412
VAL A 400
None
1.01A 5ysiA-5dqpA:
undetectable
5ysiA-5dqpA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9s SERINE--PYRUVATE
AMINOTRANSFERASE


(Homo sapiens)
PF00266
(Aminotran_5)
4 ARG A 360
GLY A  27
SER A 158
THR A 320
None
None
PLP  A 401 (-1.8A)
None
1.18A 5ysiA-5f9sA:
undetectable
5ysiA-5f9sA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcr COMPLEMENT FACTOR D

(Mus musculus)
PF00089
(Trypsin)
4 GLY A 211
SER A 197
THR A  45
VAL A 209
None
0.88A 5ysiA-5fcrA:
undetectable
5ysiA-5fcrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5


(Homo sapiens)
PF00400
(WD40)
PF12894
(ANAPC4_WD40)
4 GLY A 170
SER A 246
THR A 244
VAL A 176
None
1.17A 5ysiA-5h1kA:
undetectable
5ysiA-5h1kA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmb AZI13

(Streptomyces
sahachiroi)
PF03061
(4HBT)
4 ARG A 124
GLY A 125
THR A 114
VAL A  56
None
1.10A 5ysiA-5hmbA:
undetectable
5ysiA-5hmbA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 GLY A 129
SER A 135
THR A 133
VAL A 131
None
1.22A 5ysiA-5i8iA:
undetectable
5ysiA-5i8iA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6)
PF11651
(P22_CoatProtein)
4 GLY A 206
SER A 154
THR A 152
VAL A 149
None
1.24A 5ysiA-5l35A:
undetectable
5ysiA-5l35A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum)
PF12708
(Pectate_lyase_3)
4 GLY A 697
SER A 715
THR A 750
VAL A 735
None
1.14A 5ysiA-5m60A:
undetectable
5ysiA-5m60A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n28 METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA


(Methanotorris
formicicus)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 GLY A 428
SER A 414
THR A 419
VAL A 372
TRX  A 429 ( 2.4A)
None
None
None
1.22A 5ysiA-5n28A:
undetectable
5ysiA-5n28A:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1


(Homo sapiens)
no annotation 4 GLY B 237
SER B 265
THR B 278
VAL B 243
None
0.94A 5ysiA-5nnzB:
undetectable
5ysiA-5nnzB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1


(Homo sapiens)
no annotation 4 GLY B 237
SER B 280
THR B 278
VAL B 243
None
1.05A 5ysiA-5nnzB:
undetectable
5ysiA-5nnzB:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi)
PF00883
(Peptidase_M17)
4 ARG A 374
GLY A 373
SER A 462
THR A 369
SO4  A 601 (-4.0A)
SO4  A 601 (-3.0A)
None
None
1.20A 5ysiA-5ntfA:
undetectable
5ysiA-5ntfA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
4 ARG G 456
GLY G 458
THR G 465
VAL G 460
None
None
NAG  G 725 (-3.1A)
None
1.09A 5ysiA-5um8G:
undetectable
5ysiA-5um8G:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7


(Homo sapiens)
PF00400
(WD40)
PF12937
(F-box-like)
4 GLY B2597
SER B2641
THR B2639
VAL B2603
None
0.99A 5ysiA-5v4bB:
undetectable
5ysiA-5v4bB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7o NOSK

(Streptomyces
actuosus)
PF12697
(Abhydrolase_6)
4 GLY A 233
SER A 102
THR A 126
VAL A 236
None
1.07A 5ysiA-5v7oA:
undetectable
5ysiA-5v7oA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE


(Homo sapiens)
PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1)
4 GLY A1292
THR A1284
VAL A1031
TRP A1027
None
0.90A 5ysiA-5vadA:
undetectable
5ysiA-5vadA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrr PSEUDOKINASE FAM20A

(Homo sapiens)
PF06702
(Fam20C)
4 ARG A 227
GLY A 232
SER A 195
THR A 193
None
1.24A 5ysiA-5wrrA:
undetectable
5ysiA-5wrrA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyv RHINO

(Drosophila
melanogaster)
no annotation 4 ARG A 360
GLY A 357
SER A 388
VAL A 392
None
1.11A 5ysiA-5xyvA:
undetectable
5ysiA-5xyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aon DIHYDROLIPOYL
DEHYDROGENASE


(Bordetella
pertussis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A 206
SER A  64
VAL A 182
TRP A 202
None
1.10A 5ysiA-6aonA:
undetectable
5ysiA-6aonA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE


(Acinetobacter
baumannii)
no annotation 4 GLY A 203
SER A  63
VAL A 179
TRP A 199
None
1.06A 5ysiA-6bz0A:
undetectable
5ysiA-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd PROTEASOME SUBUNIT
BETA TYPE-4


(Rattus
norvegicus)
no annotation 4 ARG 7 138
GLY 7 112
SER 7 134
VAL 7 115
None
1.06A 5ysiA-6epd7:
undetectable
5ysiA-6epd7:
undetectable