SIMILAR PATTERNS OF AMINO ACIDS FOR 5YOD_H_BEZH201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c0a | ASPARTYL TRNASYNTHETASE (Escherichiacoli) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon)PF02938(GAD) | 4 | HIS A 449SER A 487TYR A 474GLY A 486 | AMO A 831 (-4.2A)AMO A 831 ( 4.5A)NoneAMO A 831 (-3.5A) | 0.96A | 5yodH-1c0aA:undetectable | 5yodH-1c0aA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmo | HEPARIN COFACTOR II (Homo sapiens) |
PF00079(Serpin) | 4 | HIS A 159SER A 147GLY A 144TYR A 225 | None | 1.05A | 5yodH-1jmoA:undetectable | 5yodH-1jmoA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l0w | ASPARTYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon)PF02938(GAD) | 4 | HIS A 443SER A 481TYR A 468GLY A 480 | None | 1.05A | 5yodH-1l0wA:undetectable | 5yodH-1l0wA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m1j | FIBRINOGEN GAMMACHAIN (Gallus gallus) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 4 | HIS C 343SER C 332TYR C 211GLY C 333 | None | 1.40A | 5yodH-1m1jC:undetectable | 5yodH-1m1jC:18.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uou | THYMIDINEPHOSPHORYLASE (Homo sapiens) |
PF00591(Glycos_transf_3)PF02885(Glycos_trans_3N)PF07831(PYNP_C) | 4 | HIS A 116SER A 144GLY A 145TYR A 199 | CMU A1481 (-4.3A)NoneNoneCMU A1481 (-4.7A) | 1.45A | 5yodH-1uouA:undetectable | 5yodH-1uouA:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wzz | PROBABLEENDOGLUCANASE (Komagataeibacterxylinus) |
PF01270(Glyco_hydro_8) | 4 | SER A 291TYR A 293GLY A 281TYR A 244 | None | 1.49A | 5yodH-1wzzA:undetectable | 5yodH-1wzzA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7z | HUMAN COXSACKIEVIRUSA21HUMAN COXSACKIEVIRUSA21 (Enterovirus C;Enterovirus C) |
PF00073(Rhv)PF00073(Rhv) | 4 | HIS 3 108TYR 1 200GLY 1 195TYR 1 193 | None | 1.33A | 5yodH-1z7z3:undetectable | 5yodH-1z7z3:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d1g | ACID PHOSPHATASE (Francisellatularensis) |
PF04185(Phosphoesterase) | 4 | HIS A 106SER A 103GLY A 351TYR A 353 | VO4 A 801 (-3.8A)NoneNoneNone | 1.16A | 5yodH-2d1gA:undetectable | 5yodH-2d1gA:16.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fom | POLYPROTEIN (Dengue virus) |
PF00949(Peptidase_S7) | 4 | HIS B 51SER B 135TYR B 150GLY B 151 | None | 0.55A | 5yodH-2fomB:22.9 | 5yodH-2fomB:54.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fp7 | GENOME POLYPROTEIN (West Nile virus) |
PF00949(Peptidase_S7) | 5 | HIS B 51SER B 135TYR B 150GLY B 151TYR B 161 | None | 0.48A | 5yodH-2fp7B:27.6 | 5yodH-2fp7B:62.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdw | HYPOTHETICAL PROTEINPA2218 (Pseudomonasaeruginosa) |
PF02129(Peptidase_S15) | 4 | HIS A 344SER A 319TYR A 321TYR A 214 | None | 1.49A | 5yodH-2hdwA:undetectable | 5yodH-2hdwA:21.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2whx | SERINEPROTEASE/NTPASE/HELICASE NS3 (Dengue virus) |
PF00949(Peptidase_S7)PF07652(Flavi_DEAD) | 4 | HIS A 51SER A 135TYR A 150GLY A 151 | None | 0.56A | 5yodH-2whxA:11.4 | 5yodH-2whxA:36.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ak5 | HEMOGLOBIN-BINDINGPROTEASE HBP (Escherichiacoli) |
PF02395(Peptidase_S6) | 4 | HIS A 125SER A 259GLY A 257TYR A 214 | None | 1.32A | 5yodH-3ak5A:5.9 | 5yodH-3ak5A:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bvh | FIBRINOGEN GAMMACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 4 | HIS C 343SER C 332TYR C 211GLY C 333 | None | 1.37A | 5yodH-3bvhC:undetectable | 5yodH-3bvhC:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c7o | ENDO-1,4-BETA-XYLANASE (Bacillussubtilis) |
PF03422(CBM_6)PF04616(Glyco_hydro_43) | 4 | HIS A 291SER A 239TYR A 238GLY A 228 | None | 1.27A | 5yodH-3c7oA:undetectable | 5yodH-3c7oA:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c87 | ENTEROCHELINESTERASE (Shigellaflexneri) |
PF00756(Esterase)PF11806(DUF3327) | 4 | HIS A 375SER A 307TYR A 308GLY A 306 | None | 1.25A | 5yodH-3c87A:undetectable | 5yodH-3c87A:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4w | PUTATIVEUNCHARACTERIZEDPROTEIN (Mycobacteriumavium) |
PF00199(Catalase) | 4 | HIS A 28TYR A 162GLY A 82TYR A 157 | HEM A 501 ( 3.5A)NoneHEM A 501 ( 4.2A)None | 1.43A | 5yodH-3e4wA:undetectable | 5yodH-3e4wA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqa | GLUCOAMYLASE (Aspergillusniger) |
PF00723(Glyco_hydro_15) | 4 | SER A 124TYR A 482GLY A 125TYR A 193 | None | 1.15A | 5yodH-3eqaA:undetectable | 5yodH-3eqaA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fib | FIBRINOGEN GAMMACHAIN RESIDUES (Homo sapiens) |
PF00147(Fibrinogen_C) | 4 | HIS A 343SER A 332TYR A 211GLY A 333 | None | 1.43A | 5yodH-3fibA:undetectable | 5yodH-3fibA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ghg | FIBRINOGEN GAMMACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 4 | HIS C 343SER C 332TYR C 211GLY C 333 | HIS C 343 ( 1.0A)SER C 332 ( 0.0A)TYR C 211 ( 1.3A)GLY C 333 ( 0.0A) | 1.37A | 5yodH-3ghgC:undetectable | 5yodH-3ghgC:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gzd | SELENOCYSTEINE LYASE (Homo sapiens) |
PF00266(Aminotran_5) | 4 | HIS C 322TYR C 36GLY C 419TYR C 261 | None | 1.22A | 5yodH-3gzdC:undetectable | 5yodH-3gzdC:16.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lkw | FUSION PROTEIN OFNONSTRUCTURALPROTEIN 2B ANDNONSTRUCTURALPROTEIN 3 (Dengue virus) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 4 | HIS A 101TYR A 200GLY A 201TYR A 211 | GOL A 303 (-3.7A)NoneNoneGOL A 303 (-4.8A) | 0.37A | 5yodH-3lkwA:24.5 | 5yodH-3lkwA:43.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nqp | SUSD SUPERFAMILYPROTEIN (Bacteroidesfragilis) |
PF07980(SusD_RagB)PF14322(SusD-like_3) | 4 | HIS A 381SER A 365TYR A 378GLY A 379 | NoneNoneEDO A1005 ( 3.6A)EDO A1004 ( 4.8A) | 1.50A | 5yodH-3nqpA:undetectable | 5yodH-3nqpA:17.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qg5 | RAD50 (Thermotogamaritima) |
PF13476(AAA_23)PF13558(SbcCD_C) | 4 | HIS A 131SER A 44GLY A 51TYR A 60 | None | 1.40A | 5yodH-3qg5A:undetectable | 5yodH-3qg5A:17.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3u1j | SERINE PROTEASE NS3 (Dengue virus) |
PF00949(Peptidase_S7) | 5 | HIS B 51SER B 135TYR B 150GLY B 151TYR B 161 | None | 0.57A | 5yodH-3u1jB:26.2 | 5yodH-3u1jB:54.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wai | MALTOSE-BINDINGPERIPLASMIC PROTEIN,TRANSMEMBRANEOLIGOSACCHARYLTRANSFERASE (Escherichiacoli;Archaeoglobusfulgidus) |
PF13416(SBP_bac_8) | 4 | HIS A 683SER A 768TYR A 701GLY A 769 | None | 1.20A | 5yodH-3waiA:undetectable | 5yodH-3waiA:11.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3waj | TRANSMEMBRANEOLIGOSACCHARYLTRANSFERASE (Archaeoglobusfulgidus) |
PF02516(STT3) | 4 | HIS A 683SER A 768TYR A 701GLY A 769 | None | 1.18A | 5yodH-3wajA:2.3 | 5yodH-3wajA:13.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dkn | AMPHIOXUS GREENFLUORESCENT PROTEIN,GFPA1 (Branchiostomafloridae) |
PF01353(GFP) | 4 | SER A 77TYR A 84GLY A 83TYR A 106 | None | 1.50A | 5yodH-4dknA:undetectable | 5yodH-4dknA:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2a | HYPOTHETICAL PROTEIN (Legionellapneumophila) |
PF13308(YARHG)PF14415(DUF4424) | 4 | SER A 38TYR A 186GLY A 37TYR A 170 | None | 1.28A | 5yodH-4g2aA:undetectable | 5yodH-4g2aA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gpv | PUTATIVE CELLADHESION PROTEIN (Bacteroideseggerthii) |
PF06321(P_gingi_FimA) | 4 | SER A 88TYR A 69GLY A 87TYR A 85 | None | 1.40A | 5yodH-4gpvA:undetectable | 5yodH-4gpvA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j38 | OUTER SURFACEPROTEIN E (Borreliellaburgdorferi) |
PF02471(OspE) | 4 | HIS A 81TYR A 111GLY A 113TYR A 159 | None | 1.39A | 5yodH-4j38A:undetectable | 5yodH-4j38A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mbg | CAAXFARNESYLTRANSFERASEALPHA SUBUNIT RAM2CAAXFARNESYLTRANSFERASEBETA SUBUNIT RAM1 (Aspergillusfumigatus;Aspergillusfumigatus) |
PF01239(PPTA)PF00432(Prenyltrans) | 4 | SER B 303TYR B 314GLY B 304TYR A 147 | NoneFPP B 601 (-4.4A)NoneFPP B 601 (-4.0A) | 1.44A | 5yodH-4mbgB:undetectable | 5yodH-4mbgB:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n03 | ABC-TYPEBRANCHED-CHAIN AMINOACID TRANSPORTSYSTEMS PERIPLASMICCOMPONENT-LIKEPROTEIN (Thermomonosporacurvata) |
PF13458(Peripla_BP_6) | 4 | HIS A 191SER A 247TYR A 198GLY A 199 | NoneNonePLM A 601 (-3.9A)None | 1.31A | 5yodH-4n03A:undetectable | 5yodH-4n03A:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rmf | ASPARTATE--TRNA(ASP/ASN) LIGASE (Mycolicibacteriumsmegmatis) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon)PF02938(GAD) | 4 | HIS A 449SER A 487TYR A 474GLY A 486 | FMT A 702 (-4.3A)FMT A 702 ( 4.6A)NoneFMT A 702 (-3.2A) | 1.00A | 5yodH-4rmfA:undetectable | 5yodH-4rmfA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8q | PUTATIVE RETAININGB-GLYCOSIDASE (Saccharophagusdegradans) |
PF00150(Cellulase) | 4 | HIS A 303SER A 337TYR A 300GLY A 301 | BGC A1366 ( 3.7A)BGC A1368 (-3.5A)NoneNone | 0.83A | 5yodH-5a8qA:undetectable | 5yodH-5a8qA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aho | 5' EXONUCLEASEAPOLLO (Homo sapiens) |
PF07522(DRMBL) | 4 | HIS A 36SER A 30GLY A 119TYR A 117 | ZN A1320 ( 3.4A)NoneNoneNone | 1.25A | 5yodH-5ahoA:undetectable | 5yodH-5ahoA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eue | PUTATIVESPHINGOSINE-1-PHOSPHATE LYASE (Symbiobacteriumthermophilum) |
PF00282(Pyridoxal_deC) | 4 | HIS A 441SER A 101GLY A 102TYR A 105 | NoneNonePO4 A 602 ( 3.8A)LLP A 311 (-3.9A) | 1.44A | 5yodH-5eueA:undetectable | 5yodH-5eueA:15.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5gj4 | SERINE PROTEASE NS3 (Zika virus) |
PF00949(Peptidase_S7) | 5 | HIS B 51SER B 135TYR B 150GLY B 151TYR B 161 | None | 0.35A | 5yodH-5gj4B:28.1 | 5yodH-5gj4B:99.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3h | ABHYDROLASEDOMAIN-CONTAININGPROTEIN (Exiguobacteriumantarcticum) |
PF00561(Abhydrolase_1)PF08386(Abhydrolase_4) | 4 | SER A 185TYR A 59GLY A 58TYR A 69 | None | 0.83A | 5yodH-5h3hA:undetectable | 5yodH-5h3hA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h6z | SETDOMAIN-CONTAININGPROTEIN 7 (Schizosaccharomycespombe) |
no annotation | 4 | SER A 37TYR A 99GLY A 75TYR A 61 | NoneNoneNoneNH4 A 208 ( 4.3A) | 1.40A | 5yodH-5h6zA:undetectable | 5yodH-5h6zA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5idk | GENOMEPOLYPROTEIN,SERINEPROTEASE SUBUNITNS2B, SERINEPROTEASE NS3 (West Nile virus) |
PF00949(Peptidase_S7)PF01002(Flavi_NS2B) | 5 | HIS A1051SER A1135TYR A1150GLY A1151TYR A1161 | 6A8 A1201 (-3.3A)6A8 A1201 (-1.5A)None6A8 A1201 (-4.2A)6A8 A1201 (-4.1A) | 0.50A | 5yodH-5idkA:23.7 | 5yodH-5idkA:52.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kck | ANTHRANILATESYNTHASE COMPONENT I (Streptococcuspneumoniae) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | HIS A 81SER A 83GLY A 88TYR A 127 | None | 1.35A | 5yodH-5kckA:undetectable | 5yodH-5kckA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nbq | OUTER SURFACEPROTEIN E (Borreliellaburgdorferi) |
no annotation | 4 | HIS G 81TYR G 111GLY G 113TYR G 159 | None | 1.42A | 5yodH-5nbqG:undetectable | 5yodH-5nbqG:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ngj | TAIL TUBE PROTEIN (Escherichiavirus T5) |
no annotation | 4 | HIS A 96SER A 100TYR A 128GLY A 101 | None CL A 502 (-4.2A)NoneNone | 0.96A | 5yodH-5ngjA:undetectable | 5yodH-5ngjA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w25 | ASPARTATE--TRNA(ASP/ASN) LIGASE (Mycobacteriumtuberculosis) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon)PF02938(GAD) | 4 | HIS A 452SER A 490TYR A 477GLY A 489 | ASP A 701 (-3.9A)ASP A 701 ( 4.6A)NoneASP A 701 ( 4.0A) | 0.95A | 5yodH-5w25A:undetectable | 5yodH-5w25A:15.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgs | RCC1-LIKE GEXCHANGINGFACTOR-LIKE PROTEIN (Homo sapiens) |
PF00415(RCC1)PF13540(RCC1_2) | 4 | HIS A 455TYR A 116GLY A 115TYR A 291 | None | 1.27A | 5yodH-5xgsA:undetectable | 5yodH-5xgsA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cey | BIFUNCTIONAL AAC/APH (Staphylococcusaureus) |
no annotation | 4 | HIS A 372SER A 397GLY A 395TYR A 244 | NoneNone MG A 702 ( 4.5A)None | 1.24A | 5yodH-6ceyA:2.2 | 5yodH-6ceyA:undetectable |