SIMILAR PATTERNS OF AMINO ACIDS FOR 5YOD_F_BEZF201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ac6 T-CELL RECEPTOR
ALPHA

(Mus musculus) 		PF07686
(V-set) 		4 HIS A  73
ALA A  69
SER A  71
TYR A  24
 None
 1.46A 5yodF-1ac6A:
0.0		 5yodF-1ac6A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ctt CYTIDINE DEAMINASE

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF08211
(dCMP_cyt_deam_2) 		4 HIS A 182
ALA A 199
SER A 202
TYR A 227
 None
 1.41A 5yodF-1cttA:
0.0		 5yodF-1cttA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee8 MUTM (FPG) PROTEIN

(Thermus
thermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 HIS A 228
ALA A 201
SER A 207
TYR A 214
 None
 1.40A 5yodF-1ee8A:
undetectable		 5yodF-1ee8A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h71 SERRALYSIN

(Pseudomonas sp.
'TAC II 18') 		PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 HIS P  23
ALA P 198
SER P  30
TYR P 204
 None
 1.39A 5yodF-1h71P:
undetectable		 5yodF-1h71P:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhw ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 HIS A 214
ALA A 169
SER A 244
TYR A 243
 None
NAD  A 450 (-3.5A)
None
None
 1.30A 5yodF-1nhwA:
undetectable		 5yodF-1nhwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		4 HIS A  70
ALA A  44
SER A  63
TYR A 170
 None
 1.35A 5yodF-1nrwA:
undetectable		 5yodF-1nrwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh2 SUCROSE SPECIFIC
PORIN

(Salmonella
enterica) 		PF02264
(LamB) 		4 ALA Q 334
SER Q 362
TYR Q 372
TYR Q 366
 None
 1.13A 5yodF-1oh2Q:
undetectable		 5yodF-1oh2Q:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdp BETA-AGARASE 1

(Saccharophagus
degradans) 		PF03422
(CBM_6) 		4 HIS A 115
ALA A 112
SER A 111
TYR A 109
 None
 1.43A 5yodF-2cdpA:
0.0		 5yodF-2cdpA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ALA A  18
SER A 117
TYR A 115
TYR A 415
 None
NAP  A 799 ( 4.2A)
None
None
 1.45A 5yodF-2dpgA:
0.0		 5yodF-2dpgA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 HIS A 214
ALA A 169
SER A 244
TYR A 243
 None
NAD  A 450 (-3.5A)
None
None
 1.29A 5yodF-2foiA:
undetectable		 5yodF-2foiA:
18.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		4 HIS B  51
SER B 135
TYR B 150
TYR B 161
 None
 0.59A 5yodF-2fp7B:
27.6		 5yodF-2fp7B:
62.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 ALA A 169
SER A  98
TYR A  99
TYR A 191
 None
 1.38A 5yodF-2ibdA:
undetectable		 5yodF-2ibdA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p24 H-2 CLASS II
HISTOCOMPATIBILITY
ANTIGEN, A-U BETA
CHAIN

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 ALA B   9
SER B   8
TYR B 167
TYR B 160
 None
 1.44A 5yodF-2p24B:
undetectable		 5yodF-2p24B:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		4 ALA A 177
SER A 181
TYR A 163
TYR A 147
 None
 1.36A 5yodF-3a5vA:
1.1		 5yodF-3a5vA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 HIS A 214
ALA A 169
SER A 244
TYR A 243
 None
NAD  A 801 (-3.5A)
None
None
 1.32A 5yodF-3am3A:
undetectable		 5yodF-3am3A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC

(Bordetella
parapertussis) 		no annotation 4 HIS A 268
ALA A 146
SER A 145
TYR A  67
 SO4  A 306 (-4.0A)
SO4  A 304 (-4.1A)
SO4  A 304 ( 2.7A)
SO4  A 306 (-4.7A)
 1.44A 5yodF-3d0kA:
undetectable		 5yodF-3d0kA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		4 HIS A 199
ALA A 154
SER A 229
TYR A 228
 None
NAD  A 450 (-3.5A)
None
None
 1.28A 5yodF-3f4bA:
undetectable		 5yodF-3f4bA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvx GLYCERATE
DEHYDROGENASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 HIS A  62
ALA A  55
SER A  57
TYR A  81
 None
 1.50A 5yodF-3gvxA:
undetectable		 5yodF-3gvxA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iee PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		no annotation 4 ALA A 272
SER A 270
TYR A 269
TYR A 205
 None
 1.26A 5yodF-3ieeA:
undetectable		 5yodF-3ieeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		4 HIS A  56
ALA A 132
TYR A 289
TYR A  30
 None
 1.44A 5yodF-3m7dA:
undetectable		 5yodF-3m7dA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		4 HIS A  67
ALA A  13
SER A   9
TYR A  87
 None
PAP  A 286 (-4.8A)
PAP  A 286 ( 4.7A)
None
 1.48A 5yodF-3mgbA:
undetectable		 5yodF-3mgbA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njx RHAMNOGALACTURONASE
B

(Aspergillus
aculeatus) 		PF09284
(RhgB_N)
PF14683
(CBM-like)
PF14686
(fn3_3) 		4 HIS A 188
ALA A 210
SER A 208
TYR A 216
 None
 1.31A 5yodF-3njxA:
0.5		 5yodF-3njxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwj ATSK2

(Arabidopsis
thaliana) 		PF01202
(SKI) 		4 HIS A 191
ALA A 250
SER A 195
TYR A 287
 None
 1.34A 5yodF-3nwjA:
undetectable		 5yodF-3nwjA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpi CHLORITE DISMUTASE

(Nitrobacter
winogradskyi) 		PF06778
(Chlor_dismutase) 		4 HIS A 114
ALA A 117
SER A 118
TYR A 121
 HEM  A1001 (-3.3A)
None
HEM  A1001 (-4.1A)
None
 1.30A 5yodF-3qpiA:
undetectable		 5yodF-3qpiA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 4 HIS N  34
ALA N  91
TYR N  98
TYR N 145
 None
 1.32A 5yodF-3rkoN:
undetectable		 5yodF-3rkoN:
15.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		4 HIS B  51
SER B 135
TYR B 150
TYR B 161
 None
 0.63A 5yodF-3u1jB:
26.6		 5yodF-3u1jB:
54.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 ALA A 180
SER A 201
TYR A 205
TYR A 251
 None
 1.43A 5yodF-3wc3A:
undetectable		 5yodF-3wc3A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		4 HIS A 215
ALA A  45
SER A  95
TYR A  64
 None
 1.37A 5yodF-3wl4A:
undetectable		 5yodF-3wl4A:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wyw GLUTATHIONE
S-TRANSFERASE

(Nilaparvata
lugens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ALA A 163
SER A 166
TYR A 185
TYR A 195
 None
 1.41A 5yodF-3wywA:
undetectable		 5yodF-3wywA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 ALA A 314
SER A 311
TYR A 310
TYR A 372
 None
None
NAG  A1550 (-3.8A)
None
 1.41A 5yodF-4be9A:
undetectable		 5yodF-4be9A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nql AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 HIS A 343
ALA A 354
SER A 351
TYR A 411
 None
 1.02A 5yodF-4nqlA:
undetectable		 5yodF-4nqlA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1m ENOYL-ACYL CARRIER
REDUCTASE

(Toxoplasma
gondii) 		PF13561
(adh_short_C2) 		4 HIS A 126
ALA A  81
SER A 156
TYR A 155
 None
NAD  A 401 (-3.7A)
None
None
 1.25A 5yodF-4o1mA:
undetectable		 5yodF-4o1mA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 382
ALA A 384
SER A 332
TYR A 314
 GLC  A1001 (-4.4A)
None
GLC  A1003 ( 4.7A)
GLC  A1003 ( 4.4A)
 1.38A 5yodF-4okdA:
undetectable		 5yodF-4okdA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		4 HIS A 383
ALA A 396
SER A 397
TYR A 340
 None
 1.37A 5yodF-4q76A:
undetectable		 5yodF-4q76A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9n ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Chlamydia
trachomatis) 		PF13561
(adh_short_C2) 		4 HIS A 125
ALA A  80
SER A 155
TYR A 154
 None
NAI  A 301 (-3.9A)
None
None
 1.27A 5yodF-4q9nA:
undetectable		 5yodF-4q9nA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ALA A 544
SER A 542
TYR A 417
TYR A 576
 None
 1.37A 5yodF-4w7sA:
undetectable		 5yodF-4w7sA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		4 ALA A 230
SER A 236
TYR A 179
TYR A 226
 None
 1.47A 5yodF-5ci5A:
undetectable		 5yodF-5ci5A:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gj4 SERINE PROTEASE NS3

(Zika virus) 		PF00949
(Peptidase_S7) 		4 HIS B  51
ALA B 132
TYR B 150
TYR B 161
 None
 0.45A 5yodF-5gj4B:
28.6		 5yodF-5gj4B:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gj4 SERINE PROTEASE NS3

(Zika virus) 		PF00949
(Peptidase_S7) 		4 HIS B  51
SER B 135
TYR B 150
TYR B 161
 None
 0.62A 5yodF-5gj4B:
28.6		 5yodF-5gj4B:
99.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idk GENOME
POLYPROTEIN,SERINE
PROTEASE SUBUNIT
NS2B, SERINE
PROTEASE NS3

(West Nile virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		4 HIS A1051
SER A1135
TYR A1150
TYR A1161
 6A8  A1201 (-3.3A)
6A8  A1201 (-1.5A)
None
6A8  A1201 (-4.1A)
 0.54A 5yodF-5idkA:
23.9		 5yodF-5idkA:
52.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t1v NS2B-NS3
PROTEASE,NS2B-NS3
PROTEASE

(Zika virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		4 HIS A 116
ALA A 197
SER A 200
TYR A 215
 None
 0.78A 5yodF-5t1vA:
12.5		 5yodF-5t1vA:
98.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwe PUTATIVE FIMBRIAL
ASSOCIATED
SORTASE-LIKE PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 4 HIS A 140
ALA A 145
SER A 144
TYR A  70
 None
 1.42A 5yodF-6bweA:
1.4		 5yodF-6bweA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 ALA 1  69
SER 1 166
TYR 1 168
TYR 1  66
 None
 1.41A 5yodF-6c261:
undetectable		 5yodF-6c261:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN
FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 HIS B  82
ALA A1073
SER A1231
TYR A1232
 None
 1.43A 5yodF-6ez8B:
undetectable		 5yodF-6ez8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 HIS A 598
ALA A 643
TYR A 632
TYR A 625
 None
 1.29A 5yodF-6f8zA:
undetectable		 5yodF-6f8zA:
undetectable