SIMILAR PATTERNS OF AMINO ACIDS FOR 5YN6_A_SAMA401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		5 TYR A 320
GLY A 341
GLY A 348
ASN A 340
ASP A 346
 None
 1.34A 5yn6A-1clwA:
0.0		 5yn6A-1clwA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eiz FTSJ

(Escherichia
coli) 		PF01728
(FtsJ) 		6 GLY A  59
GLY A  64
LEU A  84
ASP A  99
ASP A 124
MET A 125
 SAM  A 301 (-3.6A)
SAM  A 301 (-3.1A)
SAM  A 301 (-4.2A)
SAM  A 301 (-3.5A)
SAM  A 301 (-3.6A)
SAM  A 301 (-4.3A)
 0.90A 5yn6A-1eizA:
14.8		 5yn6A-1eizA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 GLY B 636
GLY B 554
LEU B 680
ASP B 677
ASP B 631
 None
 1.31A 5yn6A-1gl9B:
1.2		 5yn6A-1gl9B:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		5 GLY A 123
GLY A 120
ASN A 130
ASP A 142
ASP A  33
 None
 1.39A 5yn6A-1izeA:
undetectable		 5yn6A-1izeA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 TYR A 587
PRO A 646
GLY A 586
ASN A 548
ASP A 538
 None
 1.26A 5yn6A-1j0nA:
0.0		 5yn6A-1j0nA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6d ACETATE
COA-TRANSFERASE
ALPHA SUBUNIT

(Escherichia
coli) 		PF01144
(CoA_trans) 		5 PRO A 206
GLY A 207
LEU A 153
ASP A 211
PHE A  14
 None
None
None
MG  A 304 ( 4.1A)
None
 1.28A 5yn6A-1k6dA:
0.0		 5yn6A-1k6dA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwu FIBRINOGEN BETA
CHAIN

(Petromyzon
marinus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 TYR B 442
GLY B 434
ASN B 433
ASN B 282
ASP B 453
 None
 1.26A 5yn6A-1lwuB:
undetectable		 5yn6A-1lwuB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		5 TYR B 426
GLY B 418
ASN B 417
ASN B 266
ASP B 437
 None
 1.36A 5yn6A-1m1jB:
undetectable		 5yn6A-1m1jB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mda METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		5 GLY H 236
PRO H 222
LEU H 234
ASP H 237
MET H 245
 None
 1.28A 5yn6A-1mdaH:
0.0		 5yn6A-1mdaH:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1on9 METHYLMALONYL-COA
CARBOXYLTRANSFERASE
12S SUBUNIT

(Propionibacterium
freudenreichii) 		PF01039
(Carboxyl_trans) 		5 TYR A 291
GLY A 341
GLY A 290
ASN A 316
ASP A 370
 None
 1.27A 5yn6A-1on9A:
undetectable		 5yn6A-1on9A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 TYR A  17
GLY A  54
PRO A 209
ASP A  94
ASP A  53
 None
 1.28A 5yn6A-1rcqA:
undetectable		 5yn6A-1rcqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		5 TYR A 190
GLY A 112
ASN A 106
ASP A  63
ASP A 114
 None
 1.35A 5yn6A-1rh9A:
undetectable		 5yn6A-1rh9A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		5 GLY A  96
GLY A  99
LEU A 135
ASP A  97
PHE A 122
 None
 1.31A 5yn6A-1u10A:
undetectable		 5yn6A-1u10A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 TYR A 166
GLY A 133
GLY A 136
LEU A 131
ASP A 134
 FE  A 429 ( 4.3A)
None
None
None
FE  A 429 ( 3.4A)
 1.32A 5yn6A-1xzwA:
undetectable		 5yn6A-1xzwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		5 GLY A  47
PRO A  36
GLY A  50
ASN A  40
MET A  60
 None
 1.18A 5yn6A-1z34A:
undetectable		 5yn6A-1z34A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		5 TYR A 233
GLY A 136
PRO A 142
GLY A 140
LEU A 161
 None
FMN  A 301 (-3.5A)
None
None
None
 1.13A 5yn6A-1zchA:
undetectable		 5yn6A-1zchA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 GLY A 323
PRO A  11
GLY A  10
ASN A 325
PHE A 321
 None
 1.19A 5yn6A-2bi3A:
undetectable		 5yn6A-2bi3A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		5 GLY A  93
PRO A 210
GLY A 211
ASN A   5
ASP A  92
 None
 1.24A 5yn6A-2d42A:
undetectable		 5yn6A-2d42A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvj V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG, ISOFORM A

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1) 		5 GLY A 145
ASN A 144
ASP A 142
ASP A 150
PHE A 153
 None
 1.35A 5yn6A-2dvjA:
undetectable		 5yn6A-2dvjA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		5 TYR A 175
GLY A 188
GLY A 147
ASN A 122
ASP A 184
 None
 1.32A 5yn6A-2dvzA:
undetectable		 5yn6A-2dvzA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 GLY A 148
PRO A 141
GLY A 142
LEU A 217
ASP A 155
 None
 1.13A 5yn6A-2g7lA:
undetectable		 5yn6A-2g7lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT
HETEROTETRAMERIC
SARCOSINE OXIDASE
GAMMA-SUBUNIT

(Stenotrophomonas
maltophilia;
Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4)
PF04268
(SoxG) 		5 TYR A 121
PRO A 230
GLY A 231
LEU C  34
ASP C 191
 None
 1.08A 5yn6A-2gahA:
undetectable		 5yn6A-2gahA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hlp MALATE DEHYDROGENASE

(Haloarcula
marismortui) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  61
LEU A  42
ASN A  39
ASP A  73
ASP A  65
 None
 1.37A 5yn6A-2hlpA:
undetectable		 5yn6A-2hlpA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 TYR A 478
GLY A 356
ASN A 121
LEU A 363
ASP A 355
 None
 1.20A 5yn6A-2jirA:
2.9		 5yn6A-2jirA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3o TUSP1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		5 GLY A  59
GLY A  66
LEU A  43
ASN A  40
ASP A  54
 None
 1.38A 5yn6A-2k3oA:
undetectable		 5yn6A-2k3oA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		5 GLY A 351
PRO A 131
GLY A 132
ASN A 354
ASP A 285
 None
SF4  A 501 (-4.3A)
None
None
None
 1.27A 5yn6A-2n0sA:
undetectable		 5yn6A-2n0sA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyu PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2

(Homo sapiens) 		PF01728
(FtsJ) 		5 GLY A  30
LEU A  63
ASP A  79
ASP A 104
MET A 105
 SAM  A 201 (-3.5A)
SAM  A 201 (-4.2A)
SAM  A 201 (-3.3A)
SAM  A 201 (-3.7A)
SAM  A 201 (-3.9A)
 0.29A 5yn6A-2nyuA:
12.6		 5yn6A-2nyuA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odo ALANINE RACEMASE

(Pseudomonas
fluorescens) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 TYR A  17
GLY A  54
PRO A 209
ASP A  94
ASP A  53
 None
 1.26A 5yn6A-2odoA:
undetectable		 5yn6A-2odoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		5 GLY A  82
GLY A  87
LEU A 106
ASP A 132
ASP A 147
 SAM  A 300 (-3.3A)
SAM  A 300 (-3.2A)
SAM  A 300 (-4.2A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
 1.08A 5yn6A-2oxtA:
11.0		 5yn6A-2oxtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		5 GLY A  15
PRO A 123
GLY A 124
ASN A  17
ASP A 260
 None
 1.33A 5yn6A-2pfkA:
undetectable		 5yn6A-2pfkA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 TYR A 318
PRO A 317
LEU A 356
ASP A 313
MET A 310
 UNL  A   5 (-4.2A)
None
None
None
None
 1.36A 5yn6A-2q83A:
undetectable		 5yn6A-2q83A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qez ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Listeria
monocytogenes) 		PF06751
(EutB) 		5 TYR A 312
GLY A 345
GLY A 352
ASN A 131
ASP A 348
 None
 1.12A 5yn6A-2qezA:
undetectable		 5yn6A-2qezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 TYR A 167
GLY A 134
GLY A 137
LEU A 132
ASP A 135
 FE  A 433 (-4.5A)
None
None
None
FE  A 433 ( 2.9A)
 1.34A 5yn6A-2qfrA:
undetectable		 5yn6A-2qfrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfr PURPLE ACID
PHOSPHATASE

(Phaseolus
vulgaris) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 TYR A 167
GLY A 134
GLY A 137
LEU A 132
ASP A 164
 FE  A 433 (-4.5A)
None
None
None
ZN  A 434 ( 2.8A)
 1.34A 5yn6A-2qfrA:
undetectable		 5yn6A-2qfrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum) 		PF13714
(PEP_mutase) 		5 PRO A 236
GLY A 235
ASP A  66
ASP A  85
PHE A  64
 UNL  A 256 ( 4.1A)
SO4  A 255 (-3.1A)
None
None
None
 1.34A 5yn6A-2qiwA:
undetectable		 5yn6A-2qiwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A  79
GLY A 149
ASP A 199
CYH A 200
ASP A  58
 None
 0.99A 5yn6A-2rb9A:
undetectable		 5yn6A-2rb9A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		5 GLY A 380
GLY A 434
ASN A 351
ASP A 402
PHE A 354
 None
None
None
AD0  A1617 (-3.1A)
AD0  A1617 ( 4.9A)
 1.32A 5yn6A-2uvfA:
undetectable		 5yn6A-2uvfA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		5 GLY A 300
GLY A 219
ASP A 254
ASP A 301
PHE A 393
 None
 1.33A 5yn6A-2vz9A:
undetectable		 5yn6A-2vz9A:
8.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyq PUTATIVE 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		11 TYR A  47
GLY A  71
PRO A  80
GLY A  81
LEU A 100
ASN A 101
ASP A 114
CYH A 115
ASP A 130
MET A 131
PHE A 149
 SAH  A1293 (-4.8A)
SAH  A1293 (-3.8A)
SAH  A1293 (-3.8A)
SAH  A1293 (-3.6A)
SAH  A1293 (-4.3A)
SAH  A1293 ( 4.7A)
SAH  A1293 (-3.7A)
SAH  A1293 (-3.7A)
SAH  A1293 (-3.7A)
SAH  A1293 (-3.8A)
SAH  A1293 (-4.6A)
 0.37A 5yn6A-2xyqA:
45.7		 5yn6A-2xyqA:
64.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		5 PRO A 207
GLY A 206
LEU A 291
ASN A 315
ASP A 288
 None
 1.26A 5yn6A-2xziA:
undetectable		 5yn6A-2xziA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		5 TYR A 312
GLY A 345
GLY A 352
ASN A 131
ASP A 348
 None
 1.10A 5yn6A-3anyA:
undetectable		 5yn6A-3anyA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 GLY A 291
LEU A 252
ASN A 295
ASP A 251
PHE A 250
 None
 1.26A 5yn6A-3bitA:
undetectable		 5yn6A-3bitA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		5 GLY A 368
GLY A 384
ASN A 328
ASP A 333
ASP A 367
 None
 1.05A 5yn6A-3bmaA:
undetectable		 5yn6A-3bmaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 198
GLY A 202
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 1.18A 5yn6A-3c6mA:
8.6		 5yn6A-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6m SPERMINE SYNTHASE

(Homo sapiens) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		5 GLY A 198
GLY A 203
ASP A 255
CYH A 256
ASP A 276
 MTA  A 401 (-3.3A)
None
MTA  A 401 (-3.6A)
MTA  A 401 (-3.5A)
SPM  A 501 ( 3.2A)
 0.92A 5yn6A-3c6mA:
8.6		 5yn6A-3c6mA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbg O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF01596
(Methyltransf_3) 		5 GLY A  68
PRO A 120
GLY A 119
ASP A 169
ASP A  92
 SAH  A 301 (-3.7A)
SAH  A 301 (-4.5A)
None
MG  A 401 (-3.4A)
SAH  A 301 (-3.0A)
 1.36A 5yn6A-3cbgA:
9.1		 5yn6A-3cbgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddr HASR PROTEIN

(Serratia
marcescens) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 TYR A 705
GLY A 764
GLY A 767
ASN A 163
ASP A 765
 None
 1.30A 5yn6A-3ddrA:
undetectable		 5yn6A-3ddrA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dou RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Thermoplasma
volcanium) 		PF01728
(FtsJ) 		5 GLY A  46
GLY A  51
LEU A  68
ASP A  83
ASP A 111
 SAM  A   1 (-3.5A)
SAM  A   1 (-3.2A)
SAM  A   1 (-4.2A)
SAM  A   1 (-3.6A)
SAM  A   1 (-3.7A)
 0.97A 5yn6A-3douA:
7.6		 5yn6A-3douA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  86
LEU A 105
ASP A 131
ASP A 146
 SAH  A 901 (-3.4A)
SAH  A 901 (-3.1A)
SAH  A 901 (-4.0A)
SAH  A 901 (-3.7A)
SAH  A 901 (-3.8A)
 0.91A 5yn6A-3evcA:
10.6		 5yn6A-3evcA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 GLY A  81
GLY A  86
LEU A 105
ASP A 131
ASP A 146
 SAM  A4633 (-3.4A)
SAM  A4633 (-3.2A)
SAM  A4633 (-4.0A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.90A 5yn6A-3gczA:
10.9		 5yn6A-3gczA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 5 GLY A  57
PRO A  65
GLY A  64
LEU A  82
ASP A  59
 None
None
None
None
GOL  A 233 (-3.3A)
 1.32A 5yn6A-3m33A:
undetectable		 5yn6A-3m33A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgk INTRACELLULAR
PROTEASE/AMIDASE
RELATED ENZYME (THIJ
FAMILY)

(Clostridium
acetobutylicum) 		PF01965
(DJ-1_PfpI) 		5 TYR A 185
GLY A 159
ASN A 122
ASP A 161
MET A 162
 None
 1.31A 5yn6A-3mgkA:
undetectable		 5yn6A-3mgkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 GLY A 112
PRO A  83
GLY A 108
ASN A 136
ASP A 140
 None
 1.36A 5yn6A-3qdeA:
undetectable		 5yn6A-3qdeA:
15.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r24 2'-O-METHYL
TRANSFERASE

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF06460
(NSP13) 		11 TYR A  47
GLY A  71
PRO A  80
GLY A  81
LEU A 100
ASN A 101
ASP A 114
CYH A 115
ASP A 130
MET A 131
PHE A 149
 SAM  A 302 (-4.5A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.8A)
SAM  A 302 (-3.4A)
SAM  A 302 (-4.4A)
SAM  A 302 (-4.0A)
SAM  A 302 (-3.4A)
SAM  A 302 (-3.7A)
SAM  A 302 (-3.6A)
SAM  A 302 (-3.7A)
SAM  A 302 ( 4.8A)
 0.43A 5yn6A-3r24A:
45.9		 5yn6A-3r24A:
65.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3h O-METHYLTRANSFERASE,
SAM-DEPENDENT

(Legionella
pneumophila) 		PF01596
(Methyltransf_3) 		5 GLY A  68
PRO A 120
GLY A 119
ASP A 169
ASP A  92
 None
 1.29A 5yn6A-3r3hA:
7.9		 5yn6A-3r3hA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9r PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Mycobacteroides
abscessus) 		PF01259
(SAICAR_synt) 		5 GLY A 202
GLY A 207
ASP A 213
ASP A  94
MET A  95
 GLY  A 202 ( 0.0A)
GLY  A 207 ( 0.0A)
ASP  A 213 ( 0.6A)
ASP  A  94 ( 0.6A)
MET  A  95 ( 0.0A)
 1.36A 5yn6A-3r9rA:
undetectable		 5yn6A-3r9rA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty2 5'-NUCLEOTIDASE SURE

(Coxiella
burnetii) 		PF01975
(SurE) 		5 GLY A 136
ASN A 171
ASN A 102
ASP A 110
ASP A 174
 None
 1.15A 5yn6A-3ty2A:
undetectable		 5yn6A-3ty2A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0j TYPE III EFFECTOR
HOPU1

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 PRO B 109
GLY B 107
LEU B  57
ASP B  61
ASP B  51
 None
 1.22A 5yn6A-3u0jB:
undetectable		 5yn6A-3u0jB:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpi TYPE VI SECRETION
EXPORTED 1

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A  90
GLY A  48
LEU A  84
ASN A 139
ASP A 134
 None
None
None
FMT  A 206 (-3.6A)
None
 1.16A 5yn6A-3vpiA:
undetectable		 5yn6A-3vpiA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		5 GLY A 158
PRO A 499
GLY A 498
ASN A 160
PHE A 111
 None
 1.34A 5yn6A-3wajA:
undetectable		 5yn6A-3wajA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLY A 104
PRO A 115
GLY A 112
ASP A 187
PHE A 183
 GDP  A 400 ( 3.7A)
None
None
GDP  A 400 (-3.0A)
GDP  A 400 (-3.7A)
 1.36A 5yn6A-3wgkA:
undetectable		 5yn6A-3wgkA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 GLY A 198
PRO A 264
GLY A 265
ASP A 100
ASP A 197
 None
 1.37A 5yn6A-3wy2A:
undetectable		 5yn6A-3wy2A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxs CRYPTOCHROME B

(Rhodobacter
sphaeroides) 		PF04244
(DPRP) 		5 TYR A 151
GLY A 298
GLY A 305
ASN A 178
ASP A 247
 None
 1.38A 5yn6A-3zxsA:
undetectable		 5yn6A-3zxsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3s 6-PHOSPHOFRUCTOKINAS
E

(Bacillus
subtilis) 		PF00365
(PFK) 		5 GLY A  15
PRO A 123
GLY A 124
ASN A  17
ASP A 260
 None
 1.36A 5yn6A-4a3sA:
undetectable		 5yn6A-4a3sA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amt RENIN

(Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 TYR A  58
GLY A 172
ASP A  81
MET A 173
PHE A 201
 None
 1.12A 5yn6A-4amtA:
undetectable		 5yn6A-4amtA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		5 GLY A 224
GLY A 220
LEU A 204
ASP A 225
PHE A 253
 None
 1.32A 5yn6A-4c90A:
undetectable		 5yn6A-4c90A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egt MAJOR CAPSID PROTEIN
VP60

(Rabbit
hemorrhagic
disease virus) 		PF00915
(Calici_coat) 		5 GLY A 286
PRO A 447
GLY A 448
ASN A 275
ASP A 334
 None
 1.32A 5yn6A-4egtA:
undetectable		 5yn6A-4egtA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqf PEX5-RELATED PROTEIN

(Mus musculus) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		5 PRO A 232
GLY A 233
LEU A  27
ASP A  34
PHE A  41
 None
 1.27A 5yn6A-4eqfA:
undetectable		 5yn6A-4eqfA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 GLY A 186
ASN A 203
LEU A 205
ASP A 237
ASP A 255
 SAM  A 401 (-3.9A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-3.8A)
SAM  A 401 (-3.5A)
SAM  A 401 (-3.7A)
 0.97A 5yn6A-4fzvA:
undetectable		 5yn6A-4fzvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		5 GLY A 370
GLY A 360
ASN A 356
ASP A 240
MET A 282
 None
None
None
OXY  A 502 (-2.9A)
None
 1.30A 5yn6A-4gs1A:
undetectable		 5yn6A-4gs1A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 13

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M) 		5 PRO M  44
GLY M  45
ASN M  36
ASP M  68
PHE M 239
 None
 1.08A 5yn6A-4heaM:
undetectable		 5yn6A-4heaM:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 5 PRO B 664
GLY B 666
ASN B  88
ASN B 105
ASP B  85
 None
 1.38A 5yn6A-4iglB:
undetectable		 5yn6A-4iglB:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		5 TYR A 171
GLY A 232
ASN A 227
ASP A 222
ASP A 178
 None
 1.24A 5yn6A-4llfA:
undetectable		 5yn6A-4llfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 GLY A 254
GLY A 231
ASN A 154
LEU A 152
CYH A 155
 None
None
CA  A 702 (-3.1A)
None
None
 1.22A 5yn6A-4n2cA:
undetectable		 5yn6A-4n2cA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Pyrococcus
horikoshii) 		PF01259
(SAICAR_synt) 		5 GLY A 179
GLY A 184
ASP A 190
ASP A  84
MET A  85
 None
 1.31A 5yn6A-4o7zA:
undetectable		 5yn6A-4o7zA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 5 GLY A1696
LEU A1720
ASP A1755
ASP A1779
PHE A1782
 None
 1.20A 5yn6A-4uclA:
9.9		 5yn6A-4uclA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3
PROTEIN ATS1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF05207
(zf-CSL)
PF00415
(RCC1) 		5 GLY B  11
GLY B  18
ASN B  46
ASP A  29
ASP B  20
 None
DXE  B 406 (-4.5A)
None
None
DXE  B 406 (-4.1A)
 1.06A 5yn6A-4x33B:
undetectable		 5yn6A-4x33B:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ze8 ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN
(AGROCINOPINES A AND
B)

(Agrobacterium
fabrum) 		PF00496
(SBP_bac_5) 		5 TYR A 225
PRO A 228
GLY A 227
LEU A  84
ASP A  65
 None
 1.36A 5yn6A-4ze8A:
undetectable		 5yn6A-4ze8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		5 GLY A1670
GLY A1675
ASN A1692
ASP A1735
ASP A1762
 None
 1.17A 5yn6A-5a22A:
12.6		 5yn6A-5a22A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX

(Streptomyces
atroolivaceus) 		PF02585
(PIG-L) 		5 TYR A  96
PRO A  98
GLY A  97
ASN A 151
ASP A 144
 None
 1.28A 5yn6A-5bmoA:
undetectable		 5yn6A-5bmoA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLY A 389
GLY A 537
LEU A 391
ASN A 558
PHE A 398
 None
None
None
None
K  A 702 ( 4.0A)
 1.36A 5yn6A-5ck0A:
undetectable		 5yn6A-5ck0A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A 325
GLY A 241
ASP A 280
ASP A 326
PHE A 432
 None
 1.30A 5yn6A-5erbA:
undetectable		 5yn6A-5erbA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 GLY A 471
PRO A 466
GLY A 468
LEU A 473
ASN A 556
 None
 1.39A 5yn6A-5jpnA:
undetectable		 5yn6A-5jpnA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1
MCL-1 INHIBITOR

(Homo sapiens;
synthetic
construct) 		PF00452
(Bcl-2)
no annotation 		5 GLY A 219
ASN A 223
ASN B  61
ASP B  93
ASP A 218
 None
 1.19A 5yn6A-5jsbA:
undetectable		 5yn6A-5jsbA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9n POLYAMINE N
ACETYLTRANSFERASE

(Drosophila
melanogaster) 		PF00583
(Acetyltransf_1) 		5 GLY A  17
LEU A  53
ASN A  56
ASP A  49
MET A  23
 None
 1.31A 5yn6A-5k9nA:
undetectable		 5yn6A-5k9nA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus) 		no annotation 5 TYR A  58
GLY A 172
ASP A  81
MET A 173
PHE A 201
 None
 1.14A 5yn6A-5mlgA:
undetectable		 5yn6A-5mlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwb NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2

(Homo sapiens) 		PF00008
(EGF)
PF07645
(EGF_CA) 		5 GLY A 507
PRO A 527
GLY A 526
ASN A 506
ASN A 501
 None
 1.33A 5yn6A-5mwbA:
undetectable		 5yn6A-5mwbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 5 GLY A 427
GLY A 457
ASN A 428
LEU A 376
ASP A 387
 None
 1.39A 5yn6A-5ot1A:
undetectable		 5yn6A-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		5 GLY A 216
GLY A 189
ASN A  85
ASP A  56
ASP A 217
 None
None
None
None
NA  A 402 ( 2.3A)
 1.15A 5yn6A-5ubuA:
undetectable		 5yn6A-5ubuA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM3

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF17207
(MCM_OB) 		5 GLY 3 460
PRO 3 288
GLY 3 289
LEU 3 442
ASP 3 482
 None
 1.21A 5yn6A-5udb3:
undetectable		 5yn6A-5udb3:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqz GLUCAN-BINDING
PROTEIN C, GBPC

(Streptococcus
mutans) 		no annotation 5 GLY A 401
GLY A 424
ASN A 400
ASN A 395
ASP A 408
 None
None
None
None
CA  A 501 ( 4.3A)
 1.31A 5yn6A-5uqzA:
undetectable		 5yn6A-5uqzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 GLY A 290
GLY A 296
LEU A 313
ASP A 338
CYH A 339
 SAH  A 703 (-4.0A)
None
SAH  A 703 (-4.1A)
SAH  A 703 (-3.3A)
SAH  A 703 (-3.5A)
 0.73A 5yn6A-5wp4A:
9.3		 5yn6A-5wp4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 5 GLY A 290
GLY A 296
LEU A 313
ASP A 338
CYH A 339
 SAH  A 501 (-3.8A)
None
SAH  A 501 (-3.9A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.5A)
 0.73A 5yn6A-5wp5A:
undetectable		 5yn6A-5wp5A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 GLY A 205
PRO A 244
GLY A 245
ASP A 101
ASP A 204
 None
 1.32A 5yn6A-5ykbA:
undetectable		 5yn6A-5ykbA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 5 TYR A 183
GLY A 319
LEU A 337
ASN A 329
ASP A 322
 None
 1.07A 5yn6A-5yy3A:
undetectable		 5yn6A-5yy3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 GLY A 682
GLY A 346
ASN A 684
LEU A 679
ASP A 609
 None
 1.22A 5yn6A-5z06A:
undetectable		 5yn6A-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0c NEROL DEHYDROGENASE

(Persicaria
minor) 		no annotation 5 GLY A 251
GLY A 180
LEU A 265
ASP A 250
MET A 249
 None
GOL  A 404 ( 4.2A)
None
None
None
 1.33A 5yn6A-5z0cA:
undetectable		 5yn6A-5z0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zb8 PFUENDOQ

(Pyrococcus
furiosus) 		no annotation 5 GLY A  41
GLY A 113
LEU A   7
ASN A 191
PHE A  71
 None
 1.15A 5yn6A-5zb8A:
undetectable		 5yn6A-5zb8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 GLY A2237
GLY A2258
ASN A2492
LEU A2498
ASP A2236
 None
 1.34A 5yn6A-6fb3A:
undetectable		 5yn6A-6fb3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 5 GLY W 178
ASN W 225
LEU W 223
ASP W 180
PHE W 284
 None
 1.29A 5yn6A-6ftxW:
undetectable		 5yn6A-6ftxW:
undetectable