SIMILAR PATTERNS OF AMINO ACIDS FOR 5YJS_B_SALB601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfj CONSERVED
HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF02578
(Cu-oxidase_4) 		5 PHE A 236
ARG A 227
VAL A 225
PHE A  24
GLY A 226
 None
ACT  A 272 (-3.0A)
None
None
None
 1.45A 5yjsB-1xfjA:
0.0		 5yjsB-1xfjA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		9 PHE A 228
MET A 249
TYR A 260
ASN A 262
ARG A 267
VAL A 269
PHE A 324
GLY A 336
LYS A 346
 ACT  A 402 (-4.8A)
None
ACT  A 402 (-4.5A)
ACT  A 402 (-3.3A)
ACT  A 402 (-3.9A)
None
None
None
ACT  A 402 (-2.9A)
 0.34A 5yjsB-5cadA:
51.0		 5yjsB-5cadA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		5 PHE A 228
TYR A 260
VAL A 334
PHE A 324
LYS A 346
 ACT  A 402 (-4.8A)
ACT  A 402 (-4.5A)
None
None
ACT  A 402 (-2.9A)
 1.49A 5yjsB-5cadA:
51.0		 5yjsB-5cadA:
13.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 9 PHE A 227
MET A 248
TYR A 259
ASN A 261
ARG A 266
VAL A 268
PHE A 329
GLY A 341
LYS A 351
 ACT  A 502 (-4.7A)
None
ACT  A 502 (-4.5A)
ACT  A 502 (-3.3A)
ACT  A 502 (-3.9A)
None
None
None
ACT  A 502 (-2.7A)
 0.34A 5yjsB-5vf5A:
50.8		 5yjsB-5vf5A:
63.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 5 PHE A 227
TYR A 259
VAL A 339
PHE A 329
LYS A 351
 ACT  A 502 (-4.7A)
ACT  A 502 (-4.5A)
None
None
ACT  A 502 (-2.7A)
 1.49A 5yjsB-5vf5A:
50.8		 5yjsB-5vf5A:
63.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 MET A 620
TYR A 536
ASN A 532
VAL A 524
GLY A 522
 None
 1.27A 5yjsB-5z06A:
0.0		 5yjsB-5z06A:
22.73