SIMILAR PATTERNS OF AMINO ACIDS FOR 5YJS_A_SALA603_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		5 PHE M  54
GLY M 204
ASN M 466
VAL M 191
GLY M 195
 None
 0.99A 5yjsA-1dwaM:
0.0		 5yjsA-1dwaM:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		5 PHE A 241
GLY A 237
VAL A 341
PHE A 291
GLY A 340
 None
AMP  A 417 (-3.4A)
AMP  A 417 (-3.4A)
None
AMP  A 417 (-3.5A)
 1.35A 5yjsA-1hdiA:
0.0		 5yjsA-1hdiA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 PHE A 239
GLY A 235
VAL A 339
PHE A 289
GLY A 338
 MAP  A 450 (-4.8A)
MAP  A 450 (-3.5A)
MAP  A 450 (-3.3A)
None
MAP  A 450 (-3.2A)
 1.21A 5yjsA-1qpgA:
0.0		 5yjsA-1qpgA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz9 MANNONATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF03786
(UxuA) 		5 GLY A 332
TYR A   8
ARG A 336
MET A 328
GLY A 330
 None
 1.29A 5yjsA-1tz9A:
undetectable		 5yjsA-1tz9A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfj CONSERVED
HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF02578
(Cu-oxidase_4) 		5 PHE A 236
ARG A 227
VAL A 225
PHE A  24
GLY A 226
 None
ACT  A 272 (-3.0A)
None
None
None
 1.49A 5yjsA-1xfjA:
0.0		 5yjsA-1xfjA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y56 SARCOSINE OXIDASE

(Pyrococcus
horikoshii) 		PF01266
(DAO) 		5 GLY B  13
ASN B 199
VAL B  16
PHE B 333
GLY B  17
 None
None
FAD  B 800 (-3.8A)
FAD  B 800 ( 4.9A)
None
 1.31A 5yjsA-1y56B:
0.0		 5yjsA-1y56B:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 GLY A 258
MET A 261
ASN A 226
VAL A 253
PHE A 233
 None
 1.20A 5yjsA-2dieA:
undetectable		 5yjsA-2dieA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsi PUTATIVE PEPTIDASE
M23

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		5 GLY A  37
TYR A  55
ASN A 267
PHE A 100
GLY A  38
 None
 1.40A 5yjsA-2hsiA:
0.0		 5yjsA-2hsiA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsi PUTATIVE PEPTIDASE
M23

(Pseudomonas
aeruginosa) 		PF01551
(Peptidase_M23) 		5 PHE A 166
GLY A  37
VAL A  39
PHE A 276
GLY A  38
 None
 1.47A 5yjsA-2hsiA:
0.0		 5yjsA-2hsiA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 GLY A 357
TYR A 281
ARG A 355
VAL A 360
GLY A 359
 None
 1.37A 5yjsA-2htvA:
0.0		 5yjsA-2htvA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iph THIOL PROTEASE P3C

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 PHE A1025
GLY A1017
VAL A1156
PHE A1055
GLY A1140
 None
 1.45A 5yjsA-2iphA:
undetectable		 5yjsA-2iphA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3s AUTOINHIBITED CRK
PROTEIN

(Gallus gallus) 		PF00018
(SH3_1)
PF07653
(SH3_2) 		5 GLY A 285
VAL A 267
PHE A 289
GLY A 278
LYS A 246
 None
 1.00A 5yjsA-2l3sA:
undetectable		 5yjsA-2l3sA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 PHE A  48
GLY A  36
MET A  38
PHE A 406
GLY A  10
 None
 1.20A 5yjsA-2oodA:
undetectable		 5yjsA-2oodA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5n CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00878
(CIMR) 		5 GLY A1564
MET A1550
VAL A1574
PHE A1638
GLY A1575
 None
 1.46A 5yjsA-2v5nA:
undetectable		 5yjsA-2v5nA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew CAPSID PROTEIN

(Barmah Forest
virus) 		PF00944
(Peptidase_S3) 		5 PHE A 188
GLY A 191
ASN A 238
VAL A 234
LYS A 174
 None
 1.33A 5yjsA-2yewA:
undetectable		 5yjsA-2yewA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 PHE A 117
GLY A  98
TYR A 122
ASN A 125
GLY A  97
 None
HIU  A 502 ( 3.7A)
None
None
HIU  A 502 ( 3.5A)
 1.21A 5yjsA-3bptA:
undetectable		 5yjsA-3bptA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 PHE C 230
GLY C 220
MET C 218
MET C 203
GLY C 201
 None
 0.92A 5yjsA-3hrdC:
undetectable		 5yjsA-3hrdC:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT

(Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 PHE C 230
GLY C 220
MET C 218
PHE C 283
MET C 203
 None
 1.34A 5yjsA-3hrdC:
undetectable		 5yjsA-3hrdC:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1w PROTEIN PRGH

(Salmonella
enterica) 		PF09480
(PrgH) 		5 GLY A  67
ASN A  21
VAL A  40
PHE A  71
GLY A  68
 None
 1.18A 5yjsA-3j1wA:
undetectable		 5yjsA-3j1wA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN

(Xanthomonas
campestris) 		PF00378
(ECH_1) 		5 PHE A  44
GLY A 139
TYR A 106
PHE A  91
GLY A 137
 None
None
None
None
EDO  A 902 (-3.6A)
 1.34A 5yjsA-3m6mA:
undetectable		 5yjsA-3m6mA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		5 GLY A 182
ASN A 174
ARG A 179
VAL A 229
GLY A 180
 None
EDO  A 409 (-3.2A)
EDO  A 406 ( 2.9A)
None
None
 1.48A 5yjsA-3nfvA:
undetectable		 5yjsA-3nfvA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pao ADENOSINE DEAMINASE

(Pseudomonas
aeruginosa) 		PF00962
(A_deaminase) 		5 GLY A 201
ARG A 223
VAL A 222
PHE A 254
GLY A 198
 None
 1.38A 5yjsA-3paoA:
undetectable		 5yjsA-3paoA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei) 		PF01370
(Epimerase) 		5 GLY A 217
ARG A 262
VAL A 261
PHE A 202
GLY A 218
 None
 1.24A 5yjsA-3slgA:
undetectable		 5yjsA-3slgA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slg PBGP3 PROTEIN

(Burkholderia
pseudomallei) 		PF01370
(Epimerase) 		5 GLY A 217
ASN A 266
ARG A 262
PHE A 202
GLY A 218
 None
 1.46A 5yjsA-3slgA:
undetectable		 5yjsA-3slgA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk4 DIPHOSPHONUCLEOTIDE
PHOSPHATASE 1

(Lupinus luteus) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		5 GLY A 271
MET A 273
TYR A 340
PHE A 327
GLY A 312
 None
 1.49A 5yjsA-3zk4A:
undetectable		 5yjsA-3zk4A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ad9 BETA-LACTAMASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00753
(Lactamase_B) 		5 GLY A 134
ARG A  14
VAL A  36
PHE A 161
GLY A  37
 None
 1.30A 5yjsA-4ad9A:
undetectable		 5yjsA-4ad9A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed9 CAIB/BAIF FAMILY
PROTEIN

(Brucella suis) 		PF02515
(CoA_transf_3) 		5 PHE A 205
GLY A 151
TYR A 137
MET A 146
GLY A 149
 None
None
PEG  A 401 ( 4.5A)
PEG  A 401 (-4.5A)
None
 1.32A 5yjsA-4ed9A:
undetectable		 5yjsA-4ed9A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewj ENOLASE 2

(Streptococcus
suis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLY A 214
TYR A 278
VAL A 219
PHE A 242
GLY A 218
 None
 1.12A 5yjsA-4ewjA:
undetectable		 5yjsA-4ewjA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		5 GLY A  88
VAL A  91
PHE A 164
MET A  70
GLY A  90
 None
 1.15A 5yjsA-4g0bA:
undetectable		 5yjsA-4g0bA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		5 GLY A 145
ASN A 168
ARG A 178
VAL A 182
GLY A 146
 None
INS  A 401 (-3.8A)
INS  A 401 (-3.0A)
None
None
 1.47A 5yjsA-4irxA:
undetectable		 5yjsA-4irxA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		5 GLY A 337
ARG A 382
VAL A 379
PHE A 342
GLY A 338
 None
 1.07A 5yjsA-4j5tA:
1.8		 5yjsA-4j5tA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT CHL4

(Saccharomyces
cerevisiae) 		PF05238
(CENP-N) 		5 PHE B 447
GLY B 440
VAL B 385
PHE B 410
GLY B 386
 None
 1.21A 5yjsA-4je3B:
undetectable		 5yjsA-4je3B:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx6 PYRUVATE CARBOXYLASE

(Rhizobium etli) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		5 PHE A 654
ASN A 624
ARG A 621
MET A 618
GLY A 586
 KCX  A 718 ( 4.0A)
None
PYR  A1101 (-4.0A)
None
PYR  A1101 ( 3.9A)
 1.49A 5yjsA-4jx6A:
undetectable		 5yjsA-4jx6A:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		5 MET A 178
VAL A 162
PHE A 149
MET A 182
GLY A 184
 None
 1.49A 5yjsA-4pf8A:
undetectable		 5yjsA-4pf8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		7 GLY A 336
MET A 249
TYR A 260
ASN A 262
ARG A 267
PHE A 324
LYS A 346
 None
None
ACT  A 402 (-4.5A)
ACT  A 402 (-3.3A)
ACT  A 402 (-3.9A)
None
ACT  A 402 (-2.9A)
 1.20A 5yjsA-5cadA:
51.0		 5yjsA-5cadA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		9 PHE A 228
MET A 249
TYR A 260
ASN A 262
ARG A 267
VAL A 269
PHE A 324
GLY A 336
LYS A 346
 ACT  A 402 (-4.8A)
None
ACT  A 402 (-4.5A)
ACT  A 402 (-3.3A)
ACT  A 402 (-3.9A)
None
None
None
ACT  A 402 (-2.9A)
 0.31A 5yjsA-5cadA:
51.0		 5yjsA-5cadA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cad SM80.1 VICILIN

(Solanum
melongena) 		PF00190
(Cupin_1) 		5 PHE A 228
TYR A 260
VAL A 334
PHE A 324
LYS A 346
 ACT  A 402 (-4.8A)
ACT  A 402 (-4.5A)
None
None
ACT  A 402 (-2.9A)
 1.50A 5yjsA-5cadA:
51.0		 5yjsA-5cadA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn DNA PRIMASE/HELICASE

(Escherichia
virus T7) 		PF03796
(DnaB_C)
PF13155
(Toprim_2) 		5 ASN D 296
VAL D 516
PHE D 321
MET D 533
GLY D 531
 None
 1.50A 5yjsA-5iknD:
undetectable		 5yjsA-5iknD:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		5 PHE A 118
GLY A 112
MET A 114
ASN A 140
GLY A 143
 None
 1.26A 5yjsA-5infA:
undetectable		 5yjsA-5infA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 PHE A 181
GLY A 172
MET A 174
ASN A 144
MET A 158
 None
 1.41A 5yjsA-5jozA:
undetectable		 5yjsA-5jozA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		5 GLY A  88
VAL A  91
PHE A 164
MET A  70
GLY A  90
 None
 1.16A 5yjsA-5kjuA:
undetectable		 5yjsA-5kjuA:
11.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 7 GLY A 341
MET A 248
TYR A 259
ASN A 261
ARG A 266
PHE A 329
LYS A 351
 None
None
ACT  A 502 (-4.5A)
ACT  A 502 (-3.3A)
ACT  A 502 (-3.9A)
None
ACT  A 502 (-2.7A)
 1.19A 5yjsA-5vf5A:
50.7		 5yjsA-5vf5A:
63.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 9 PHE A 227
MET A 248
TYR A 259
ASN A 261
ARG A 266
VAL A 268
PHE A 329
GLY A 341
LYS A 351
 ACT  A 502 (-4.7A)
None
ACT  A 502 (-4.5A)
ACT  A 502 (-3.3A)
ACT  A 502 (-3.9A)
None
None
None
ACT  A 502 (-2.7A)
 0.31A 5yjsA-5vf5A:
50.7		 5yjsA-5vf5A:
63.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vf5 SM80.1 VICILIN

(Solanum
melongena) 		no annotation 5 PHE A 227
TYR A 259
VAL A 339
PHE A 329
LYS A 351
 ACT  A 502 (-4.7A)
ACT  A 502 (-4.5A)
None
None
ACT  A 502 (-2.7A)
 1.49A 5yjsA-5vf5A:
50.7		 5yjsA-5vf5A:
63.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 MET A 620
TYR A 536
ASN A 532
VAL A 524
GLY A 522
 None
 1.26A 5yjsA-5z06A:
2.0		 5yjsA-5z06A:
22.73