SIMILAR PATTERNS OF AMINO ACIDS FOR 5YJ1_T_6ELT501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 HIS A 508
THR A 221
TRP A  61
PHE A  93
 CU  A 556 (-3.3A)
None
None
None
 1.15A 5yj1k-1asoA:
undetectable
5yj1t-1asoA:
0.0		 5yj1k-1asoA:
11.49
5yj1t-1asoA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		4 THR A 328
HIS A 238
TRP A 212
TRP A 213
 BGC  A 403 ( 4.5A)
None
None
BGC  A 401 ( 3.8A)
 1.28A 5yj1k-1eceA:
0.0
5yj1t-1eceA:
0.0		 5yj1k-1eceA:
18.28
5yj1t-1eceA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gw1 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Cellvibrio
japonicus) 		PF02156
(Glyco_hydro_26) 		4 HIS A  79
THR A  82
TRP A 191
PHE A 250
 None
 1.20A 5yj1k-1gw1A:
0.0
5yj1t-1gw1A:
0.0		 5yj1k-1gw1A:
14.89
5yj1t-1gw1A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 TRP A 545
HIS A 547
TRP A 510
PHE A 386
 None
 0.88A 5yj1k-1m1cA:
undetectable
5yj1t-1m1cA:
undetectable		 5yj1k-1m1cA:
8.33
5yj1t-1m1cA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 THR A 227
HIS A 180
TRP A 194
PHE A 193
 None
G6D  A 505 ( 3.7A)
None
None
 1.41A 5yj1k-1ua7A:
0.2
5yj1t-1ua7A:
0.0		 5yj1k-1ua7A:
13.30
5yj1t-1ua7A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		4 HIS A  29
THR A 223
HIS A  72
PHE A  50
 None
NA  A 302 (-3.5A)
PO4  A 301 (-3.7A)
None
 1.40A 5yj1k-1vk1A:
0.0
5yj1t-1vk1A:
0.0		 5yj1k-1vk1A:
19.23
5yj1t-1vk1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 THR A 414
HIS A 615
TRP A 610
PHE A 619
 None
 1.31A 5yj1k-2wanA:
0.5
5yj1t-2wanA:
0.5		 5yj1k-2wanA:
8.11
5yj1t-2wanA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		4 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A1504 ( 4.6A)
None
 1.43A 5yj1k-2wsxA:
undetectable
5yj1t-2wsxA:
undetectable		 5yj1k-2wsxA:
12.84
5yj1t-2wsxA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		4 HIS A 223
HIS A 267
TRP A  25
TRP A 291
 None
 1.23A 5yj1k-2xsbA:
undetectable
5yj1t-2xsbA:
undetectable		 5yj1k-2xsbA:
14.29
5yj1t-2xsbA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 HIS A 491
THR A 496
HIS A 365
TRP A 335
 3ES  A1611 (-3.9A)
3ES  A1611 (-3.4A)
ZN  A1620 ( 3.2A)
PEG  A1622 ( 4.0A)
 1.39A 5yj1k-2xydA:
0.0
5yj1t-2xydA:
undetectable		 5yj1k-2xydA:
10.03
5yj1t-2xydA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axx 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 THR A 386
HIS A 297
TRP A 272
TRP A 273
 None
None
None
CBI  A 459 (-3.9A)
 1.25A 5yj1k-3axxA:
undetectable
5yj1t-3axxA:
undetectable		 5yj1k-3axxA:
12.97
5yj1t-3axxA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 HIS A 311
THR A 312
HIS A 152
PHE A  31
 None
 1.07A 5yj1k-3gm8A:
undetectable
5yj1t-3gm8A:
undetectable		 5yj1k-3gm8A:
8.78
5yj1t-3gm8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq0 CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
alkylphenolica) 		PF00903
(Glyoxalase) 		4 HIS A 248
THR A 255
HIS A 215
PHE A  69
 None
 1.19A 5yj1k-3hq0A:
undetectable
5yj1t-3hq0A:
undetectable		 5yj1k-3hq0A:
16.67
5yj1t-3hq0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k81 SINGLE STRAND
ANTIBODY VHH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 THR A 115
TRP A  36
TRP A  34
PHE A  29
 None
 1.08A 5yj1k-3k81A:
undetectable
5yj1t-3k81A:
undetectable		 5yj1k-3k81A:
19.12
5yj1t-3k81A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tnl SHIKIMATE
DEHYDROGENASE

(Listeria
monocytogenes) 		PF08501
(Shikimate_dh_N) 		4 HIS A 110
THR A 108
HIS A 278
PHE A  36
 None
 1.35A 5yj1k-3tnlA:
undetectable
5yj1t-3tnlA:
undetectable		 5yj1k-3tnlA:
18.18
5yj1t-3tnlA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 THR A 341
TRP A 419
HIS A 174
TRP A 426
 None
 1.24A 5yj1k-3v1vA:
undetectable
5yj1t-3v1vA:
undetectable		 5yj1k-3v1vA:
13.41
5yj1t-3v1vA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		4 HIS B  13
THR B 134
HIS B  59
PHE B 238
 FE2  B 401 ( 3.4A)
None
None
None
 1.25A 5yj1k-3vsjB:
undetectable
5yj1t-3vsjB:
undetectable		 5yj1k-3vsjB:
21.39
5yj1t-3vsjB:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		4 THR A  83
HIS A  58
TRP A  70
TRP A  71
 None
 1.35A 5yj1k-3vvlA:
undetectable
5yj1t-3vvlA:
undetectable		 5yj1k-3vvlA:
13.80
5yj1t-3vvlA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		4 HIS A  47
TRP A 255
TRP A 252
PHE A 232
 CL  A 807 (-4.3A)
None
EPE  A 804 (-4.0A)
None
 1.25A 5yj1k-3w5fA:
undetectable
5yj1t-3w5fA:
undetectable		 5yj1k-3w5fA:
9.37
5yj1t-3w5fA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6m 458AA LONG
HYPOTHETICAL
ENDO-1,4-BETA-GLUCAN
ASE

(Pyrococcus
horikoshii) 		PF00150
(Cellulase) 		4 THR A 386
HIS A 297
TRP A 272
TRP A 273
 None
 1.27A 5yj1k-3w6mA:
undetectable
5yj1t-3w6mA:
undetectable		 5yj1k-3w6mA:
14.13
5yj1t-3w6mA:
14.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 HIS B 355
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.5A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 1.19A 5yj1k-4ci2B:
17.6
5yj1t-4ci2B:
17.1		 5yj1k-4ci2B:
34.47
5yj1t-4ci2B:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.30A 5yj1k-4ci2B:
17.6
5yj1t-4ci2B:
17.1		 5yj1k-4ci2B:
34.47
5yj1t-4ci2B:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.34A 5yj1k-4m8jA:
undetectable
5yj1t-4m8jA:
undetectable		 5yj1k-4m8jA:
12.10
5yj1t-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 758
THR A 777
TRP A 809
HIS A 849
 None
 1.30A 5yj1k-4okdA:
undetectable
5yj1t-4okdA:
undetectable		 5yj1k-4okdA:
8.82
5yj1t-4okdA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5b THYMIDYLATE SYNTHASE
THYX

(Streptomyces
cacaoi) 		PF02511
(Thy1) 		4 THR A 194
HIS A 188
TRP A  90
PHE A  92
 None
FAD  A 301 (-4.0A)
None
None
 1.33A 5yj1k-4p5bA:
undetectable
5yj1t-4p5bA:
undetectable		 5yj1k-4p5bA:
17.96
5yj1t-4p5bA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.22A 5yj1k-4rd8A:
undetectable
5yj1t-4rd8A:
undetectable		 5yj1k-4rd8A:
19.34
5yj1t-4rd8A:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 5 HIS C 380
TRP C 382
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 ( 4.9A)
EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.21A 5yj1k-4tzcC:
20.1
5yj1t-4tzcC:
19.7		 5yj1k-4tzcC:
98.17
5yj1t-4tzcC:
98.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		4 THR A 439
HIS A 174
TRP A 177
PHE A 195
 None
MN  A 581 (-3.3A)
None
None
 1.21A 5yj1k-4uwqA:
undetectable
5yj1t-4uwqA:
undetectable		 5yj1k-4uwqA:
12.34
5yj1t-4uwqA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		4 HIS A  40
THR A  42
HIS A  53
TRP A  18
 None
None
MN  A 200 (-3.6A)
None
 1.14A 5yj1k-4uxaA:
undetectable
5yj1t-4uxaA:
undetectable		 5yj1k-4uxaA:
17.56
5yj1t-4uxaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF13458
(Peripla_BP_6) 		4 HIS A 203
THR A 195
TRP A 240
PHE A 317
 None
None
ACT  A 500 ( 4.0A)
ACT  A 500 ( 4.9A)
 1.46A 5yj1k-4xfkA:
undetectable
5yj1t-4xfkA:
undetectable		 5yj1k-4xfkA:
16.08
5yj1t-4xfkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.32A 5yj1k-4zq8A:
undetectable
5yj1t-4zq8A:
undetectable		 5yj1k-4zq8A:
16.30
5yj1t-4zq8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 HIS Z 353
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.9A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 1.25A 5yj1k-5hxbZ:
10.1
5yj1t-5hxbZ:
9.7		 5yj1k-5hxbZ:
27.62
5yj1t-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.51A 5yj1k-5hxbZ:
10.1
5yj1t-5hxbZ:
9.7		 5yj1k-5hxbZ:
27.62
5yj1t-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkd GLUTATHIONE
S-TRANSFERASE
OMEGA-LIKE 2

(Saccharomyces
cerevisiae) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 HIS A  50
THR A 337
TRP A 322
PHE A 211
 None
 1.41A 5yj1k-5lkdA:
undetectable
5yj1t-5lkdA:
undetectable		 5yj1k-5lkdA:
14.36
5yj1t-5lkdA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK

(Candidatus
Pelagibacter
ubique) 		PF07883
(Cupin_2) 		4 THR A  54
HIS A  58
TRP A  26
PHE A  28
 None
NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
 1.28A 5yj1k-5tfzA:
undetectable
5yj1t-5tfzA:
undetectable		 5yj1k-5tfzA:
20.51
5yj1t-5tfzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wpi HSVA

(Erwinia
amylovora) 		no annotation 4 HIS A  56
HIS A 217
TRP A 176
TRP A 139
 HIS  A  56 ( 1.0A)
HIS  A 217 ( 1.0A)
TRP  A 176 ( 0.5A)
TRP  A 139 ( 0.5A)
 1.13A 5yj1k-5wpiA:
undetectable
5yj1t-5wpiA:
undetectable		 5yj1k-5wpiA:
12.05
5yj1t-5wpiA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 THR A 160
HIS A 366
TRP A 361
PHE A 370
 None
 1.36A 5yj1k-5ww1A:
undetectable
5yj1t-5ww1A:
undetectable		 5yj1k-5ww1A:
undetectable
5yj1t-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 4 HIS A 460
THR A 451
HIS A 343
PHE A 436
 None
 1.28A 5yj1k-6eomA:
undetectable
5yj1t-6eomA:
undetectable		 5yj1k-6eomA:
undetectable
5yj1t-6eomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 HIS A 553
TRP A 548
HIS A 520
PHE A 600
 None
 1.06A 5yj1k-6etzA:
undetectable
5yj1t-6etzA:
undetectable		 5yj1k-6etzA:
undetectable
5yj1t-6etzA:
undetectable