SIMILAR PATTERNS OF AMINO ACIDS FOR 5YJ1_G_6ELG501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aso ASCORBATE OXIDASE

(Cucurbita pepo) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 TRP A  61
PHE A  93
HIS A 508
THR A 221
 None
None
CU  A 556 (-3.3A)
None
 1.16A 5yj1G-1asoA:
undetectable
5yj1Y-1asoA:
0.0		 5yj1G-1asoA:
11.49
5yj1Y-1asoA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 HIS A 393
PHE A 346
HIS A 381
THR A 528
 None
 1.24A 5yj1G-1c2oA:
0.0
5yj1Y-1c2oA:
undetectable		 5yj1G-1c2oA:
11.09
5yj1Y-1c2oA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		4 HIS A 238
TRP A 212
TRP A 213
THR A 328
 None
None
BGC  A 401 ( 3.8A)
BGC  A 403 ( 4.5A)
 1.33A 5yj1G-1eceA:
0.0
5yj1Y-1eceA:
0.0		 5yj1G-1eceA:
18.28
5yj1Y-1eceA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 HIS A 547
TRP A 510
PHE A 386
TRP A 545
 None
 0.88A 5yj1G-1m1cA:
0.0
5yj1Y-1m1cA:
undetectable		 5yj1G-1m1cA:
8.33
5yj1Y-1m1cA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 HIS A 180
TRP A 194
PHE A 193
THR A 227
 G6D  A 505 ( 3.7A)
None
None
None
 1.37A 5yj1G-1ua7A:
0.4
5yj1Y-1ua7A:
0.4		 5yj1G-1ua7A:
13.30
5yj1Y-1ua7A:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		4 HIS A  72
PHE A  50
HIS A  29
THR A 223
 PO4  A 301 (-3.7A)
None
None
NA  A 302 (-3.5A)
 1.44A 5yj1G-1vk1A:
0.0
5yj1Y-1vk1A:
0.0		 5yj1G-1vk1A:
19.23
5yj1Y-1vk1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0t PUTATIVE
GAMMA-CARBOXYMUCONOL
ACTONE DECARBOXYLASE
SUBUNIT

(Paraburkholderia
xenovorans) 		PF02627
(CMD) 		4 HIS A  21
PHE A  89
HIS A 237
THR A 234
 None
 1.46A 5yj1G-2q0tA:
undetectable
5yj1Y-2q0tA:
undetectable		 5yj1G-2q0tA:
14.94
5yj1Y-2q0tA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qri H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN K-B ALPHA
CHAIN, BETA-2
MICROGLOBULIN,
OVALBUMIN-DERIVED
PEPTIDE

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 TRP A  95
PHE A  70
HIS A 188
THR A 190
 None
 0.95A 5yj1G-2qriA:
undetectable
5yj1Y-2qriA:
undetectable		 5yj1G-2qriA:
12.90
5yj1Y-2qriA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 615
TRP A 610
PHE A 619
THR A 414
 None
 1.29A 5yj1G-2wanA:
0.5
5yj1Y-2wanA:
0.5		 5yj1G-2wanA:
8.11
5yj1Y-2wanA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 HIS A 365
TRP A 335
HIS A 491
THR A 496
 ZN  A1620 ( 3.2A)
PEG  A1622 ( 4.0A)
3ES  A1611 (-3.9A)
3ES  A1611 (-3.4A)
 1.45A 5yj1G-2xydA:
undetectable
5yj1Y-2xydA:
0.0		 5yj1G-2xydA:
10.03
5yj1Y-2xydA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 PHE A  46
HIS A 231
THR A 233
TRP A 224
 None
 1.37A 5yj1G-2yrrA:
undetectable
5yj1Y-2yrrA:
undetectable		 5yj1G-2yrrA:
16.93
5yj1Y-2yrrA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dca RPA0582

(Rhodopseudomonas
palustris) 		PF07045
(DUF1330) 		4 TRP A  86
PHE A  74
HIS A   4
THR A   2
 None
 1.32A 5yj1G-3dcaA:
undetectable
5yj1Y-3dcaA:
undetectable		 5yj1G-3dcaA:
24.32
5yj1Y-3dcaA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		4 HIS A 456
TRP A 453
PHE A 450
HIS A 495
 None
 1.42A 5yj1G-3drkA:
undetectable
5yj1Y-3drkA:
undetectable		 5yj1G-3drkA:
11.19
5yj1Y-3drkA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgt PUTATIVE
PHOSPHOLIPASE B-LIKE
2 28 KDA FORM
PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM

(Mus musculus;
Mus musculus) 		PF04916
(Phospholip_B)
PF04916
(Phospholip_B) 		4 TRP B 584
TRP B 567
HIS A 138
THR A 142
 None
 1.47A 5yj1G-3fgtB:
undetectable
5yj1Y-3fgtB:
undetectable		 5yj1G-3fgtB:
16.05
5yj1Y-3fgtB:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgw PUTATIVE
PHOSPHOLIPASE B-LIKE
2

(Mus musculus) 		PF04916
(Phospholip_B) 		4 TRP A 584
TRP A 567
HIS A 138
THR A 142
 None
 1.44A 5yj1G-3fgwA:
undetectable
5yj1Y-3fgwA:
undetectable		 5yj1G-3fgwA:
10.84
5yj1Y-3fgwA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 HIS A 152
PHE A  31
HIS A 311
THR A 312
 None
 1.00A 5yj1G-3gm8A:
undetectable
5yj1Y-3gm8A:
undetectable		 5yj1G-3gm8A:
8.78
5yj1Y-3gm8A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq0 CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
alkylphenolica) 		PF00903
(Glyoxalase) 		4 HIS A 215
PHE A  69
HIS A 248
THR A 255
 None
 1.18A 5yj1G-3hq0A:
undetectable
5yj1Y-3hq0A:
undetectable		 5yj1G-3hq0A:
16.67
5yj1Y-3hq0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k81 SINGLE STRAND
ANTIBODY VHH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 TRP A  34
PHE A  29
THR A 115
TRP A  36
 None
 1.08A 5yj1G-3k81A:
undetectable
5yj1Y-3k81A:
undetectable		 5yj1G-3k81A:
19.12
5yj1Y-3k81A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 HIS A 174
TRP A 426
THR A 341
TRP A 419
 None
 1.30A 5yj1G-3v1vA:
undetectable
5yj1Y-3v1vA:
undetectable		 5yj1G-3v1vA:
13.41
5yj1Y-3v1vA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		4 HIS A  58
TRP A  70
TRP A  71
THR A  83
 None
 1.41A 5yj1G-3vvlA:
undetectable
5yj1Y-3vvlA:
undetectable		 5yj1G-3vvlA:
13.80
5yj1Y-3vvlA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5f BETA-GALACTOSIDASE

(Solanum
lycopersicum) 		PF01301
(Glyco_hydro_35) 		4 TRP A 255
TRP A 252
PHE A 232
HIS A  47
 None
EPE  A 804 (-4.0A)
None
CL  A 807 (-4.3A)
 1.32A 5yj1G-3w5fA:
undetectable
5yj1Y-3w5fA:
undetectable		 5yj1G-3w5fA:
9.37
5yj1Y-3w5fA:
9.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.28A 5yj1G-4ci2B:
17.0
5yj1Y-4ci2B:
17.4		 5yj1G-4ci2B:
34.47
5yj1Y-4ci2B:
34.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 TRP B 388
TRP B 402
PHE B 404
HIS B 355
 LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
LVY  B1429 (-4.5A)
 1.21A 5yj1G-4ci2B:
17.0
5yj1Y-4ci2B:
17.4		 5yj1G-4ci2B:
34.47
5yj1Y-4ci2B:
34.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0x MALONYL-COA
DECARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF05292
(MCD)
PF17408
(MCD_N) 		4 TRP A 189
PHE A 194
HIS A 143
THR A  60
 None
 1.25A 5yj1G-4f0xA:
undetectable
5yj1Y-4f0xA:
undetectable		 5yj1G-4f0xA:
12.85
5yj1Y-4f0xA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 HIS A 255
PHE A 216
HIS A 341
THR A  38
 None
 1.05A 5yj1G-4hwvA:
undetectable
5yj1Y-4hwvA:
undetectable		 5yj1G-4hwvA:
13.17
5yj1Y-4hwvA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 HIS A 141
TRP A 324
TRP A 147
TRP A 142
 None
NM2  A 601 (-3.8A)
None
None
 1.41A 5yj1G-4m8jA:
undetectable
5yj1Y-4m8jA:
undetectable		 5yj1G-4m8jA:
12.10
5yj1Y-4m8jA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 849
HIS A 758
THR A 777
TRP A 809
 None
 1.25A 5yj1G-4okdA:
undetectable
5yj1Y-4okdA:
undetectable		 5yj1G-4okdA:
8.82
5yj1Y-4okdA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5b THYMIDYLATE SYNTHASE
THYX

(Streptomyces
cacaoi) 		PF02511
(Thy1) 		4 HIS A 188
TRP A  90
PHE A  92
THR A 194
 FAD  A 301 (-4.0A)
None
None
None
 1.34A 5yj1G-4p5bA:
undetectable
5yj1Y-4p5bA:
undetectable		 5yj1G-4p5bA:
17.96
5yj1Y-4p5bA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 HIS A 129
TRP A 133
PHE A  86
THR A 176
 None
 1.22A 5yj1G-4rd8A:
undetectable
5yj1Y-4rd8A:
undetectable		 5yj1G-4rd8A:
19.34
5yj1Y-4rd8A:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 5 HIS C 380
TRP C 382
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 ( 4.9A)
EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.15A 5yj1G-4tzcC:
19.6
5yj1Y-4tzcC:
20.5		 5yj1G-4tzcC:
98.17
5yj1Y-4tzcC:
98.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		4 HIS A 174
TRP A 177
PHE A 195
THR A 439
 MN  A 581 (-3.3A)
None
None
None
 1.22A 5yj1G-4uwqA:
undetectable
5yj1Y-4uwqA:
undetectable		 5yj1G-4uwqA:
12.34
5yj1Y-4uwqA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxa CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		4 HIS A  53
TRP A  18
HIS A  40
THR A  42
 MN  A 200 (-3.6A)
None
None
None
 1.14A 5yj1G-4uxaA:
undetectable
5yj1Y-4uxaA:
undetectable		 5yj1G-4uxaA:
17.56
5yj1Y-4uxaA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfk PUTATIVE BRANCHED
CHAIN AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF13458
(Peripla_BP_6) 		4 TRP A 240
PHE A 317
HIS A 203
THR A 195
 ACT  A 500 ( 4.0A)
ACT  A 500 ( 4.9A)
None
None
 1.44A 5yj1G-4xfkA:
undetectable
5yj1Y-4xfkA:
undetectable		 5yj1G-4xfkA:
16.08
5yj1Y-4xfkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 HIS A  85
TRP A 338
THR A 255
TRP A 331
 None
 1.37A 5yj1G-4zq8A:
undetectable
5yj1Y-4zq8A:
undetectable		 5yj1G-4zq8A:
16.30
5yj1Y-4zq8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG

(Homo sapiens) 		PF02724
(CDC45) 		4 HIS A 541
TRP A  55
HIS A 194
THR A 100
 None
 1.28A 5yj1G-5dgoA:
undetectable
5yj1Y-5dgoA:
undetectable		 5yj1G-5dgoA:
12.23
5yj1Y-5dgoA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.48A 5yj1G-5hxbZ:
9.7
5yj1Y-5hxbZ:
9.9		 5yj1G-5hxbZ:
27.62
5yj1Y-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 TRP Z 386
TRP Z 400
PHE Z 402
HIS Z 353
 85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.9A)
 1.23A 5yj1G-5hxbZ:
9.7
5yj1Y-5hxbZ:
9.9		 5yj1G-5hxbZ:
27.62
5yj1Y-5hxbZ:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4
NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL

(Bos taurus;
Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N)
PF00146
(NADHdh) 		4 HIS M 440
TRP M 358
PHE h  21
THR M 365
 None
 1.09A 5yj1G-5lc5M:
undetectable
5yj1Y-5lc5M:
undetectable		 5yj1G-5lc5M:
12.44
5yj1Y-5lc5M:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK

(Candidatus
Pelagibacter
ubique) 		PF07883
(Cupin_2) 		4 HIS A  58
TRP A  26
PHE A  28
THR A  54
 NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
None
 1.26A 5yj1G-5tfzA:
undetectable
5yj1Y-5tfzA:
undetectable		 5yj1G-5tfzA:
20.51
5yj1Y-5tfzA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 4 HIS A 156
TRP A 176
PHE A 175
THR A 254
 None
 1.10A 5yj1G-5wh8A:
undetectable
5yj1Y-5wh8A:
undetectable		 5yj1G-5wh8A:
undetectable
5yj1Y-5wh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 HIS A 366
TRP A 361
PHE A 370
THR A 160
 None
 1.34A 5yj1G-5ww1A:
undetectable
5yj1Y-5ww1A:
undetectable		 5yj1G-5ww1A:
undetectable
5yj1Y-5ww1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0e FREE SERINE KINASE

(Thermococcus
kodakarensis) 		PF02195
(ParBc) 		4 HIS A  72
PHE A  50
HIS A  29
THR A 223
 AMP  A 301 ( 3.6A)
AMP  A 301 (-3.8A)
SEP  A 302 ( 4.8A)
SEP  A 302 (-3.9A)
 1.35A 5yj1G-5x0eA:
undetectable
5yj1Y-5x0eA:
undetectable		 5yj1G-5x0eA:
16.74
5yj1Y-5x0eA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 HIS A 520
PHE A 600
HIS A 553
TRP A 548
 None
 1.10A 5yj1G-6etzA:
undetectable
5yj1Y-6etzA:
undetectable		 5yj1G-6etzA:
undetectable
5yj1Y-6etzA:
undetectable