SIMILAR PATTERNS OF AMINO ACIDS FOR 5YJ0_T_EF2T501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 TRP A 545
HIS A 547
TRP A 510
PHE A 386
 None
 0.89A 5yj0k-1m1cA:
0.0
5yj0t-1m1cA:
0.0		 5yj0k-1m1cA:
7.65
5yj0t-1m1cA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 THR A 227
HIS A 180
TRP A 194
PHE A 193
 None
G6D  A 505 ( 3.7A)
None
None
 1.40A 5yj0k-1ua7A:
0.3
5yj0t-1ua7A:
0.3		 5yj0k-1ua7A:
11.14
5yj0t-1ua7A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 THR A 414
HIS A 615
TRP A 610
PHE A 619
 None
 1.26A 5yj0k-2wanA:
0.5
5yj0t-2wanA:
0.5		 5yj0k-2wanA:
7.23
5yj0t-2wanA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k81 SINGLE STRAND
ANTIBODY VHH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 THR A 115
TRP A  36
TRP A  34
PHE A  29
 None
 1.11A 5yj0k-3k81A:
0.0
5yj0t-3k81A:
0.0		 5yj0k-3k81A:
18.60
5yj0t-3k81A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 THR A 341
TRP A 419
HIS A 174
TRP A 426
 None
 1.34A 5yj0k-3v1vA:
undetectable
5yj0t-3v1vA:
undetectable		 5yj0k-3v1vA:
11.48
5yj0t-3v1vA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		4 THR A  83
HIS A  58
TRP A  70
TRP A  71
 None
 1.44A 5yj0k-3vvlA:
0.0
5yj0t-3vvlA:
0.0		 5yj0k-3vvlA:
10.49
5yj0t-3vvlA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.27A 5yj0k-4ci2B:
17.8
5yj0t-4ci2B:
17.0		 5yj0k-4ci2B:
17.79
5yj0t-4ci2B:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.43A 5yj0k-4m8jA:
undetectable
5yj0t-4m8jA:
undetectable		 5yj0k-4m8jA:
9.07
5yj0t-4m8jA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.22A 5yj0k-4rd8A:
undetectable
5yj0t-4rd8A:
undetectable		 5yj0k-4rd8A:
16.18
5yj0t-4rd8A:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 5 HIS C 380
TRP C 382
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 ( 4.9A)
EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.14A 5yj0k-4tzcC:
20.2
5yj0t-4tzcC:
19.7		 5yj0k-4tzcC:
97.50
5yj0t-4tzcC:
97.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		4 THR A 439
HIS A 174
TRP A 177
PHE A 195
 None
MN  A 581 (-3.3A)
None
None
 1.27A 5yj0k-4uwqA:
0.0
5yj0t-4uwqA:
0.0		 5yj0k-4uwqA:
10.91
5yj0t-4uwqA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.39A 5yj0k-4zq8A:
undetectable
5yj0t-4zq8A:
undetectable		 5yj0k-4zq8A:
13.89
5yj0t-4zq8A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.41A 5yj0k-5hxbZ:
10.2
5yj0t-5hxbZ:
9.7		 5yj0k-5hxbZ:
21.39
5yj0t-5hxbZ:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00146
(NADHdh)
PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		4 THR M 365
HIS M 440
TRP M 358
PHE h  21
 None
 1.07A 5yj0k-5lc5M:
undetectable
5yj0t-5lc5M:
undetectable		 5yj0k-5lc5M:
10.54
5yj0t-5lc5M:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK

(Candidatus
Pelagibacter
ubique) 		PF07883
(Cupin_2) 		4 THR A  54
HIS A  58
TRP A  26
PHE A  28
 None
NI  A 201 ( 3.3A)
7BC  A 202 (-3.6A)
None
 1.32A 5yj0k-5tfzA:
undetectable
5yj0t-5tfzA:
undetectable		 5yj0k-5tfzA:
20.67
5yj0t-5tfzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 THR A 160
HIS A 366
TRP A 361
PHE A 370
 None
 1.31A 5yj0k-5ww1A:
undetectable
5yj0t-5ww1A:
undetectable		 5yj0k-5ww1A:
17.05
5yj0t-5ww1A:
17.05