SIMILAR PATTERNS OF AMINO ACIDS FOR 5YF9_X_NIOX401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		5 LEU A 375
VAL A 341
VAL A 333
ILE A 266
PHE A 356
 None
 0.89A 5yf9X-1g38A:
undetectable		 5yf9X-1g38A:
11.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 VAL A  53
LYS A  68
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.79A 5yf9X-1m2pA:
47.5		 5yf9X-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 VAL A  53
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.34A 5yf9X-1m2pA:
47.5		 5yf9X-1m2pA:
70.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 LEU A  45
VAL A 467
VAL A 469
ILE A  69
ASP A 444
 None
 1.07A 5yf9X-1o99A:
undetectable		 5yf9X-1o99A:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		5 LEU A 112
VAL A 109
VAL A  80
ILE A  91
ILE A   7
 None
 1.22A 5yf9X-1qhxA:
undetectable		 5yf9X-1qhxA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A 213
VAL A  73
VAL A  94
ILE A 145
ASP A  88
 None
 1.24A 5yf9X-1rqjA:
undetectable		 5yf9X-1rqjA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tie ERYTHRINA TRYPSIN
INHIBITOR

(Erythrina
caffra) 		PF00197
(Kunitz_legume) 		5 LEU A 154
VAL A 101
VAL A  43
ILE A  56
ILE A  75
 None
 1.14A 5yf9X-1tieA:
undetectable		 5yf9X-1tieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0j DNA REPLICATION
PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF01057
(Parvo_NS1) 		5 LEU A 284
VAL A 466
ILE A 330
PHE A 316
ILE A 417
 None
 1.15A 5yf9X-1u0jA:
undetectable		 5yf9X-1u0jA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgj HYPOTHETICAL PROTEIN
PH0099

(Pyrococcus
horikoshii) 		PF02834
(LigT_PEase) 		5 LEU A  17
VAL A  13
VAL A  75
ILE A  41
ASP A   8
 None
 1.17A 5yf9X-1vgjA:
undetectable		 5yf9X-1vgjA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		5 LEU A 332
VAL A  41
ILE A  15
ILE A  70
ASP A  69
 None
 1.16A 5yf9X-1y3nA:
undetectable		 5yf9X-1y3nA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yhn RAS-RELATED PROTEIN
RAB-7

(Homo sapiens) 		PF00071
(Ras) 		5 LEU A 123
VAL A  87
VAL A  85
ILE A  61
ASP A  63
 None
None
None
None
MG  A 302 (-2.7A)
 1.12A 5yf9X-1yhnA:
undetectable		 5yf9X-1yhnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7d ORNITHINE
AMINOTRANSFERASE

(Plasmodium
yoelii) 		PF00202
(Aminotran_3) 		5 LEU A 215
VAL A 252
VAL A 247
ILE A 257
ASP A 255
 None
 1.21A 5yf9X-1z7dA:
undetectable		 5yf9X-1z7dA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.61A 5yf9X-1zaoA:
10.9		 5yf9X-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 None
None
None
GOL  A3001 (-4.8A)
GOL  A3001 ( 3.9A)
None
 0.72A 5yf9X-2a2aA:
27.4		 5yf9X-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.4A)
GOL  A3001 ( 3.9A)
None
 1.17A 5yf9X-2a2aA:
27.4		 5yf9X-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF14681
(UPRTase) 		5 LEU A 127
VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 1.22A 5yf9X-2e55A:
undetectable		 5yf9X-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekd HYPOTHETICAL PROTEIN
PH0250

(Pyrococcus
horikoshii) 		PF03192
(DUF257) 		5 LEU A 177
VAL A  18
VAL A  16
ILE A 113
ILE A  33
 None
 0.92A 5yf9X-2ekdA:
undetectable		 5yf9X-2ekdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
LYS A 186
PHE A 236
ASP A 320
 None
 0.72A 5yf9X-2eu9A:
27.3		 5yf9X-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  38
VAL A  46
ILE A 100
ILE A 181
ASP A 182
 HB1  A1289 ( 4.1A)
HB1  A1289 (-3.6A)
HB1  A1289 (-4.1A)
HB1  A1289 (-3.7A)
HB1  A1289 (-4.2A)
 0.87A 5yf9X-2iwiA:
24.4		 5yf9X-2iwiA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o30 NUCLEAR MOVEMENT
PROTEIN

(Encephalitozoon
cuniculi) 		PF04969
(CS) 		5 LEU A  63
VAL A  76
VAL A  74
ILE A  50
ILE A  40
 None
 1.00A 5yf9X-2o30A:
undetectable		 5yf9X-2o30A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ock VALACYCLOVIR
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		5 LEU A 212
VAL A 215
VAL A 242
ILE A 221
ILE A 144
 None
 1.25A 5yf9X-2ockA:
undetectable		 5yf9X-2ockA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okm COLLAGEN ADHESIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		5 VAL A 137
VAL A  59
ILE A 159
ILE A  72
ASP A  74
 None
 1.08A 5yf9X-2okmA:
undetectable		 5yf9X-2okmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okm COLLAGEN ADHESIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		5 VAL A 137
VAL A  59
ILE A 159
PHE A  40
ASP A  74
 None
 1.01A 5yf9X-2okmA:
undetectable		 5yf9X-2okmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 VAL A  33
LYS A  48
ILE A  87
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
MN  A 382 (-2.0A)
 0.61A 5yf9X-2phkA:
25.9		 5yf9X-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 487
VAL A 495
LYS A 517
ILE A 548
ASP A 644
 None
 1.13A 5yf9X-2psqA:
23.7		 5yf9X-2psqA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		6 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.61A 5yf9X-2pywA:
8.8		 5yf9X-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 353
VAL A 318
VAL A 155
ILE A 234
ILE A 196
 None
 1.04A 5yf9X-2qygA:
undetectable		 5yf9X-2qygA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		6 VAL A 498
LYS A 511
ILE A 557
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 ( 4.5A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.58A 5yf9X-2vuwA:
15.7		 5yf9X-2vuwA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.81A 5yf9X-2w4kA:
27.2		 5yf9X-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
LYS A  42
ILE A  77
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.2A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 1.01A 5yf9X-2w4kA:
27.2		 5yf9X-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  52
VAL A  60
LYS A  75
ILE A 102
ASP A 185
 DKI  A1338 (-3.8A)
DKI  A1338 (-4.2A)
None
DKI  A1338 ( 4.4A)
DKI  A1338 (-3.8A)
 1.02A 5yf9X-2w4oA:
21.5		 5yf9X-2w4oA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 112
VAL A 120
LYS A 135
ILE A 164
ILE A 246
 16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
16X  A1374 ( 4.3A)
None
16X  A1374 (-4.1A)
 0.91A 5yf9X-2x4fA:
26.5		 5yf9X-2x4fA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 120
LYS A 135
ILE A 164
ILE A 246
ASP A 247
 16X  A1374 (-4.8A)
16X  A1374 ( 4.3A)
None
16X  A1374 (-4.1A)
None
 1.01A 5yf9X-2x4fA:
26.5		 5yf9X-2x4fA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Arabidopsis
thaliana) 		PF06090
(Ins_P5_2-kin) 		5 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.77A 5yf9X-2xalA:
3.8		 5yf9X-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb3 PSBP PROTEIN

(Thermosynechococcus
elongatus) 		PF01789
(PsbP) 		5 LEU A 157
VAL A  69
VAL A  67
PHE A  57
ASP A  31
 None
None
None
None
ZN  A1001 (-2.2A)
 0.97A 5yf9X-2xb3A:
undetectable		 5yf9X-2xb3A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  38
LYS A  53
ILE A  91
PHE A 107
ASP A 171
 None
None
B49  A1294 ( 4.6A)
B49  A1294 (-4.0A)
B49  A1294 (-4.2A)
 0.99A 5yf9X-2y7jA:
27.1		 5yf9X-2y7jA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  19
VAL A  27
LYS A  42
ILE A  77
ILE A 160
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.8A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.79A 5yf9X-2yabA:
27.5		 5yf9X-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  27
LYS A  42
ILE A  77
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 3.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.93A 5yf9X-2yabA:
27.5		 5yf9X-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 LEU A 102
VAL A  98
ILE A 249
ILE A 184
ASP A 156
 None
 1.25A 5yf9X-2yh2A:
undetectable		 5yf9X-2yh2A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 LEU A 102
VAL A  98
VAL A 300
ILE A 184
ASP A 156
 None
 1.26A 5yf9X-2yh2A:
undetectable		 5yf9X-2yh2A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1p COLLAGEN ADHESIN
PROTEIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		5 VAL A 276
VAL A 198
ILE A 298
ILE A 211
ASP A 213
 None
 1.04A 5yf9X-2z1pA:
undetectable		 5yf9X-2z1pA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1p COLLAGEN ADHESIN
PROTEIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		5 VAL A 276
VAL A 198
ILE A 298
PHE A 179
ASP A 213
 None
 1.00A 5yf9X-2z1pA:
undetectable		 5yf9X-2z1pA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
LYS A  42
ILE A  77
MET A 146
ILE A 160
ASP A 161
 4RB  A 401 ( 4.4A)
4RB  A 401 ( 2.8A)
4RB  A 401 ( 4.3A)
4RB  A 401 (-2.8A)
4RB  A 401 (-3.5A)
GOL  A 503 ( 3.1A)
 0.79A 5yf9X-3bqrA:
23.8		 5yf9X-3bqrA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A1005
VAL A1013
VAL A1026
LYS A1028
ILE A1065
ILE A1145
ASP A1146
 ADP  A   1 (-4.1A)
ADP  A   1 ( 4.5A)
ADP  A   1 ( 4.4A)
ADP  A   1 (-3.0A)
ADP  A   1 (-4.0A)
ADP  A   1 (-4.0A)
MG  A   8 (-2.3A)
 0.60A 5yf9X-3dlsA:
24.5		 5yf9X-3dlsA:
13.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU X  46
VAL X  54
VAL X  67
LYS X  69
PHE X 114
ILE X 175
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
 1.00A 5yf9X-3e3bX:
46.8		 5yf9X-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU X  46
VAL X  54
VAL X  67
PHE X 114
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.13A 5yf9X-3e3bX:
46.8		 5yf9X-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL X  54
VAL X  67
ILE X  96
PHE X 114
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.04A 5yf9X-3e3bX:
46.8		 5yf9X-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL X  54
VAL X  67
LYS X  69
ILE X  96
PHE X 114
ILE X 175
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 ( 4.6A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
 0.93A 5yf9X-3e3bX:
46.8		 5yf9X-3e3bX:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		5 LEU A 189
VAL A 127
ILE A 143
PHE A 165
ILE A 139
 None
 1.23A 5yf9X-3e3xA:
undetectable		 5yf9X-3e3xA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 LEU A  15
VAL A  23
LYS A  38
ILE A  63
ASP A 185
 DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 ( 4.7A)
 0.93A 5yf9X-3eb0A:
29.2		 5yf9X-3eb0A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.58A 5yf9X-3f2aA:
25.0		 5yf9X-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 ( 4.7A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.39A 5yf9X-3f2aA:
25.0		 5yf9X-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3

(Campylobacter
jejuni) 		PF13531
(SBP_bac_11) 		5 LEU A  24
VAL A  51
VAL A  49
ILE A  37
ASP A  36
 None
 0.91A 5yf9X-3fj7A:
undetectable		 5yf9X-3fj7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 LEU A 270
VAL A 266
ILE A 189
PHE A 241
ILE A 254
 None
None
None
SAH  A 350 (-3.6A)
None
 1.23A 5yf9X-3gxoA:
undetectable		 5yf9X-3gxoA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iln LAMINARINASE

(Rhodothermus
marinus) 		PF00722
(Glyco_hydro_16) 		5 VAL A 250
VAL A 252
ILE A 178
MET A 112
ILE A 132
 None
 1.16A 5yf9X-3ilnA:
undetectable		 5yf9X-3ilnA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A 141
VAL A 149
LYS A 164
ILE A 194
ILE A 280
ASP A 281
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.8A)
ANP  A   1 (-4.2A)
MG  A 399 ( 3.0A)
 1.00A 5yf9X-3is5A:
23.6		 5yf9X-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		6 LEU A 141
VAL A 149
VAL A 162
LYS A 164
ILE A 194
ILE A 280
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
ANP  A   1 (-4.4A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.8A)
ANP  A   1 (-4.2A)
 0.77A 5yf9X-3is5A:
23.6		 5yf9X-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		5 LEU A 190
VAL A  50
VAL A  71
ILE A 122
ASP A  65
 None
 1.24A 5yf9X-3p8rA:
undetectable		 5yf9X-3p8rA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 VAL A 250
LYS A 252
MET A 358
ILE A 368
ASP A 369
 None
 0.95A 5yf9X-4azvA:
9.2		 5yf9X-4azvA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 VAL A 250
LYS A 252
MET A 358
ILE A 368
ASP A 369
 ATP  A1450 ( 4.8A)
ATP  A1450 (-2.9A)
ATP  A1450 ( 4.2A)
ATP  A1450 (-4.2A)
MG  A1453 (-2.0A)
 0.94A 5yf9X-4azwA:
9.1		 5yf9X-4azwA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 LEU A 327
VAL A 325
VAL A 349
ILE A 409
ILE A 407
 None
 1.24A 5yf9X-4flnA:
undetectable		 5yf9X-4flnA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		5 LEU A 194
VAL A 199
VAL A 223
ILE A 268
PHE A 230
 None
 0.92A 5yf9X-4gz2A:
undetectable		 5yf9X-4gz2A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 LEU A  94
VAL A 111
VAL A  92
ILE A 115
ILE A 121
 None
 1.03A 5yf9X-4h5uA:
undetectable		 5yf9X-4h5uA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 LEU A 132
VAL A 140
LYS A 158
ILE A 190
ASP A 270
 None
 1.13A 5yf9X-4hzsA:
20.1		 5yf9X-4hzsA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iiw LMO1499 PROTEIN

(Listeria
monocytogenes) 		PF02618
(YceG) 		5 LEU A  94
VAL A  68
VAL A  48
ILE A  59
MET A 107
 None
 1.26A 5yf9X-4iiwA:
undetectable		 5yf9X-4iiwA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		5 LEU A 178
VAL A 186
VAL A 198
ILE A 337
ASP A 338
 None
None
None
None
MG  A 601 (-2.6A)
 0.87A 5yf9X-4ix3A:
21.1		 5yf9X-4ix3A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcr ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Listeria
monocytogenes) 		PF00574
(CLP_protease) 		5 LEU A  42
VAL A  38
VAL A  24
ILE A  57
ILE A  96
 None
 1.18A 5yf9X-4jcrA:
undetectable		 5yf9X-4jcrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		5 VAL A  63
LYS A  80
MET A 203
ILE A 211
ASP A 212
 1L7  A 301 ( 4.8A)
1L7  A 301 (-2.8A)
1L7  A 301 ( 4.3A)
1L7  A 301 (-4.4A)
1L7  A 301 (-3.6A)
 0.92A 5yf9X-4jinA:
6.5		 5yf9X-4jinA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 VAL A  54
VAL A  67
LYS A  69
ILE A 134
PHE A 152
MET A 202
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
None
None
GNP  A 401 (-3.6A)
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.60A 5yf9X-4jr7A:
44.6		 5yf9X-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrj EFFECTOR NLEH1

(Escherichia
coli) 		no annotation 5 VAL A 147
VAL A 157
LYS A 159
ILE A 257
ASP A 258
 ANP  A 301 (-4.2A)
ANP  A 301 (-4.9A)
ANP  A 301 (-3.6A)
ANP  A 301 (-4.2A)
MG  A 302 ( 2.9A)
 1.08A 5yf9X-4lrjA:
9.4		 5yf9X-4lrjA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 5 LEU B 247
VAL B 186
VAL B 188
ILE B 324
ILE B 363
 None
 0.97A 5yf9X-4lwoB:
undetectable		 5yf9X-4lwoB:
9.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU E  45
VAL E  53
VAL E  66
PHE E 113
ASP E 175
 None
 0.68A 5yf9X-4md8E:
29.6		 5yf9X-4md8E:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL E  53
VAL E  66
LYS E  68
ILE E  95
PHE E 113
MET E 163
ILE E 174
ASP E 175
 None
 0.54A 5yf9X-4md8E:
29.6		 5yf9X-4md8E:
77.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL E  53
VAL E  66
LYS E  68
ILE E 174
PHE E 113
 None
 1.24A 5yf9X-4md8E:
29.6		 5yf9X-4md8E:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o96 TYPE III EFFECTOR
PROTEIN KINASE

(Escherichia
coli) 		no annotation 5 VAL A 157
VAL A 167
LYS A 169
ILE A 267
ASP A 268
 GOL  A 401 ( 4.9A)
GOL  A 401 (-4.7A)
None
GOL  A 401 (-4.6A)
None
 1.03A 5yf9X-4o96A:
8.7		 5yf9X-4o96A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0f SERINE PROTEASE
INHIBITOR 4, ISOFORM
B

(Drosophila
melanogaster) 		PF00079
(Serpin) 		5 LEU A  24
VAL A  20
VAL A 284
ILE A 315
PHE A 285
 None
 0.94A 5yf9X-4p0fA:
undetectable		 5yf9X-4p0fA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 801
VAL A 819
LYS A 821
ILE A 945
ASP A 946
 ADP  A1501 (-3.8A)
None
ADP  A1501 (-2.7A)
ADP  A1501 ( 3.9A)
MG  A1503 (-1.7A)
 0.61A 5yf9X-4qpmA:
18.4		 5yf9X-4qpmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyi HYPOXANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		5 LEU A 122
VAL A  94
VAL A  96
ILE A  64
ILE A  85
 None
 1.17A 5yf9X-4qyiA:
undetectable		 5yf9X-4qyiA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqx SORTASE

(Streptococcus
mutans) 		PF04203
(Sortase) 		5 LEU A 155
VAL A 216
ILE A 164
ILE A  98
ASP A 100
 None
 1.23A 5yf9X-4tqxA:
undetectable		 5yf9X-4tqxA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
VAL A 492
LYS A 514
ILE A 545
ASP A 641
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.0A)
 1.01A 5yf9X-5a46A:
19.7		 5yf9X-5a46A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8z NEUTROPHIL ELASTASE

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU A 123
ILE A 103
PHE A 234
MET A  53
ILE A 212
 None
 1.20A 5yf9X-5a8zA:
undetectable		 5yf9X-5a8zA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7w UPF0234 PROTEIN
XC_3703

(Xanthomonas
campestris) 		PF04461
(DUF520) 		5 LEU A 112
VAL A 119
VAL A 130
ILE A 142
ASP A 140
 None
 1.21A 5yf9X-5b7wA:
undetectable		 5yf9X-5b7wA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		5 VAL A 548
LYS A 563
ILE A 595
ILE A 674
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.9A)
None
 0.82A 5yf9X-5ezrA:
22.4		 5yf9X-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
VAL A 911
LYS A 930
ILE A 960
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.6A)
5U3  A1200 ( 4.9A)
 0.93A 5yf9X-5f1zA:
23.3		 5yf9X-5f1zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  35
LYS A  52
ILE A  79
PHE A  97
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
FMT  A 403 ( 3.3A)
 0.77A 5yf9X-5idnA:
13.5		 5yf9X-5idnA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A  22
VAL A  30
LYS A  45
ILE A  77
ASP A 157
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-3.5A)
 0.97A 5yf9X-5isoA:
25.2		 5yf9X-5isoA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jod PROPLASMEPSIN IV

(Plasmodium
falciparum) 		PF00026
(Asp) 		5 LEU A 244
VAL A 246
VAL A 239
ILE A 280
ASP A 281
 None
 1.20A 5yf9X-5jodA:
undetectable		 5yf9X-5jodA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 163
LYS A 178
ILE A 212
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.64A 5yf9X-5lxdA:
27.4		 5yf9X-5lxdA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  45
VAL A  53
VAL A  66
LYS A  68
PHE A 113
ASP A 175
 HC4  A 401 ( 4.8A)
None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 (-4.0A)
 0.69A 5yf9X-5movA:
48.2		 5yf9X-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  45
VAL A  66
LYS A  68
ILE A 174
PHE A 113
 HC4  A 401 ( 4.8A)
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-3.4A)
 1.24A 5yf9X-5movA:
48.2		 5yf9X-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  53
VAL A  66
LYS A  68
ILE A  95
PHE A 113
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 ( 4.5A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.27A 5yf9X-5movA:
48.2		 5yf9X-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  53
VAL A  66
LYS A  68
PHE A 113
MET A 163
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 4.0A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.64A 5yf9X-5movA:
48.2		 5yf9X-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqi PYRIDOXAL KINASE
PDXY

(Burkholderia
multivorans) 		PF08543
(Phos_pyr_kin) 		5 LEU A 195
VAL A 197
VAL A 179
ILE A 156
ASP A 164
 None
 1.19A 5yf9X-5tqiA:
undetectable		 5yf9X-5tqiA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 VAL A  52
LYS A  67
ILE A 104
ILE A 185
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 (-4.8A)
7LK  A 401 ( 4.3A)
None
 0.63A 5yf9X-5turA:
24.9		 5yf9X-5turA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u32 TRNA LIGASE

(Candida
albicans) 		no annotation 5 LEU A 463
VAL A 471
ILE A 486
PHE A 473
ILE A 490
 None
 1.24A 5yf9X-5u32A:
undetectable		 5yf9X-5u32A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  57
LYS A  72
ILE A  99
PHE A 117
MET A 167
ILE A 178
 ATP  A 403 (-3.9A)
ATP  A 403 (-3.2A)
ATP  A 403 (-4.9A)
None
ATP  A 403 ( 3.7A)
ATP  A 403 ( 4.5A)
 0.77A 5yf9X-5xvuA:
45.4		 5yf9X-5xvuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 6 VAL A 223
LYS A 238
ILE A 272
PHE A 288
ILE A 354
ASP A 355
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.3A)
HRM  A 601 ( 4.8A)
HRM  A 601 (-3.6A)
HRM  A 601 (-3.7A)
HRM  A 601 (-4.7A)
 0.50A 5yf9X-5y86A:
19.1		 5yf9X-5y86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 5 LEU B 235
VAL B 205
VAL B 203
MET B  95
ASP B 178
 None
None
None
None
MG  B 804 ( 3.8A)
 1.07A 5yf9X-5yewB:
undetectable		 5yf9X-5yewB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2m -

(-) 		no annotation 5 LEU A 123
VAL A  87
VAL A  85
ILE A  61
ASP A  63
 None
None
None
None
MG  A 201 ( 3.9A)
 1.24A 5yf9X-5z2mA:
undetectable		 5yf9X-5z2mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 LEU A 222
VAL A 252
VAL A 254
LYS A 267
ILE A 349
 None
None
MGD  A 902 (-4.5A)
None
None
 1.19A 5yf9X-6czaA:
undetectable		 5yf9X-6czaA:
undetectable