SIMILAR PATTERNS OF AMINO ACIDS FOR 5YF9_B_NIOB401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 VAL A  14
VAL A  76
PHE A 113
ILE A 125
 None
 0.73A 5yf9B-1cvrA:
undetectable		 5yf9B-1cvrA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 217
VAL A 222
ILE A 184
ASP A 185
 None
 0.76A 5yf9B-1i41A:
undetectable		 5yf9B-1i41A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 VAL A 210
VAL A 208
PHE A 160
ASP A 146
 None
 0.80A 5yf9B-1k1xA:
undetectable		 5yf9B-1k1xA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 VAL A 184
VAL A 182
ILE A 126
ASP A 128
 None
 0.79A 5yf9B-1kyhA:
undetectable		 5yf9B-1kyhA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		4 VAL A  31
LYS A  44
ILE A 207
ASP A 208
 ADP  A 300 ( 4.8A)
ADP  A 300 (-2.7A)
ADP  A 300 (-4.1A)
MG  A 302 (-2.1A)
 0.62A 5yf9B-1l8tA:
8.4		 5yf9B-1l8tA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 VAL A 178
MET A 158
ILE A 233
ASP A 232
 None
 0.90A 5yf9B-1lehA:
undetectable		 5yf9B-1lehA:
13.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 VAL A  53
LYS A  68
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.83A 5yf9B-1m2pA:
47.6		 5yf9B-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 VAL A  53
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.39A 5yf9B-1m2pA:
47.6		 5yf9B-1m2pA:
70.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 VAL A 173
MET A  51
ILE A 275
ASP A 274
 None
None
None
EDO  A 313 (-3.1A)
 0.79A 5yf9B-1pyfA:
undetectable		 5yf9B-1pyfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A 172
LYS A 187
PHE A 246
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
ADP  A 810 ( 3.0A)
 0.58A 5yf9B-1q8yA:
20.8		 5yf9B-1q8yA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		4 VAL B 170
VAL B 168
PHE B 129
ILE B 108
 None
 0.90A 5yf9B-1y43B:
undetectable		 5yf9B-1y43B:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.59A 5yf9B-1zaoA:
6.8		 5yf9B-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  27
LYS A  42
ILE A 160
ASP A 161
 None
 0.90A 5yf9B-1zwsA:
27.2		 5yf9B-1zwsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyl HYPOTHETICAL PROTEIN
YIHE

(Escherichia
coli) 		PF01636
(APH) 		4 VAL A  41
VAL A  53
PHE A 106
ASP A 217
 None
 0.83A 5yf9B-1zylA:
7.3		 5yf9B-1zylA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 281
VAL B 294
LYS B 296
ASP B 432
 None
 0.44A 5yf9B-2a1aB:
21.6		 5yf9B-2a1aB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.4A)
GOL  A3001 ( 3.9A)
None
 1.18A 5yf9B-2a2aA:
26.8		 5yf9B-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF14681
(UPRTase) 		4 VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 0.43A 5yf9B-2e55A:
undetectable		 5yf9B-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 170
LYS A 186
PHE A 236
ASP A 320
 None
 0.64A 5yf9B-2eu9A:
27.3		 5yf9B-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 VAL A  93
VAL A 109
LYS A 107
ASP A 245
 None
 0.81A 5yf9B-2f7lA:
undetectable		 5yf9B-2f7lA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o52 RAS-RELATED PROTEIN
RAB-4B

(Homo sapiens) 		PF00071
(Ras) 		5 VAL A  52
VAL A  57
LYS A  55
PHE A   7
ASP A 174
 None
 1.03A 5yf9B-2o52A:
undetectable		 5yf9B-2o52A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okm COLLAGEN ADHESIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		4 VAL A 137
VAL A  59
PHE A  40
ASP A  74
 None
 0.89A 5yf9B-2okmA:
undetectable		 5yf9B-2okmA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
MN  A 382 (-2.0A)
 0.58A 5yf9B-2phkA:
25.3		 5yf9B-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 VAL A  46
LYS A  61
ILE A 249
ASP A 250
 ACP  A 999 (-4.6A)
ACP  A 999 (-2.9A)
None
MG  A 401 ( 2.8A)
 0.74A 5yf9B-2punA:
9.1		 5yf9B-2punA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		6 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.62A 5yf9B-2pywA:
9.0		 5yf9B-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		4 VAL A 266
VAL A 248
PHE A  93
ILE A 221
 None
 0.85A 5yf9B-2qtsA:
undetectable		 5yf9B-2qtsA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzb UNCHARACTERIZED
PROTEIN YFEY

(Escherichia
coli) 		PF06572
(DUF1131) 		4 VAL A  87
LYS A  89
ILE A 114
ASP A 113
 None
 0.62A 5yf9B-2qzbA:
undetectable		 5yf9B-2qzbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 VAL A 498
LYS A 511
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.46A 5yf9B-2vuwA:
15.3		 5yf9B-2vuwA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.98A 5yf9B-2w4kA:
26.6		 5yf9B-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Arabidopsis
thaliana) 		PF06090
(Ins_P5_2-kin) 		5 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.76A 5yf9B-2xalA:
2.8		 5yf9B-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.87A 5yf9B-2yabA:
27.0		 5yf9B-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1p COLLAGEN ADHESIN
PROTEIN

(Enterococcus
faecalis) 		PF05737
(Collagen_bind) 		4 VAL A 276
VAL A 198
PHE A 179
ASP A 213
 None
 0.85A 5yf9B-2z1pA:
undetectable		 5yf9B-2z1pA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z99 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF04079
(SMC_ScpB) 		4 VAL A 132
VAL A 127
PHE A 167
ILE A 153
 None
 0.84A 5yf9B-2z99A:
undetectable		 5yf9B-2z99A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 VAL A 264
VAL A 129
LYS A 131
ASP A 305
 None
 0.72A 5yf9B-3actA:
undetectable		 5yf9B-3actA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 4RB  A 401 ( 4.4A)
4RB  A 401 ( 2.8A)
4RB  A 401 (-2.8A)
4RB  A 401 (-3.5A)
GOL  A 503 ( 3.1A)
 0.82A 5yf9B-3bqrA:
23.2		 5yf9B-3bqrA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A1013
VAL A1026
LYS A1028
ILE A1145
ASP A1146
 ADP  A   1 ( 4.5A)
ADP  A   1 ( 4.4A)
ADP  A   1 (-3.0A)
ADP  A   1 (-4.0A)
MG  A   8 (-2.3A)
 0.58A 5yf9B-3dlsA:
23.7		 5yf9B-3dlsA:
13.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL X  54
VAL X  67
LYS X  69
PHE X 114
MET X 164
ILE X 175
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
 1.05A 5yf9B-3e3bX:
46.8		 5yf9B-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL X  54
VAL X  67
PHE X 114
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.09A 5yf9B-3e3bX:
46.8		 5yf9B-3e3bX:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eey PUTATIVE RRNA
METHYLASE

(Ruminiclostridium
thermocellum) 		PF06962
(rRNA_methylase) 		4 VAL A  92
VAL A  25
PHE A  49
ASP A  89
 None
 0.90A 5yf9B-3eeyA:
undetectable		 5yf9B-3eeyA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.33A 5yf9B-3f2aA:
18.7		 5yf9B-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 VAL A  78
VAL A 127
PHE A 149
ILE A  67
 None
 0.84A 5yf9B-3g7sA:
undetectable		 5yf9B-3g7sA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		4 VAL A   5
VAL A   7
ILE A 413
ASP A 412
 None
 0.84A 5yf9B-3hidA:
undetectable		 5yf9B-3hidA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  90
LYS A 105
ILE A 218
ASP A 219
 ANP  A 610 (-3.9A)
ANP  A 610 (-2.8A)
ANP  A 610 ( 4.4A)
ANP  A 610 ( 2.7A)
 0.84A 5yf9B-3igoA:
20.1		 5yf9B-3igoA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 VAL A 149
VAL A 162
LYS A 164
ILE A 280
 ANP  A   1 (-4.9A)
ANP  A   1 (-4.4A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.2A)
 0.60A 5yf9B-3is5A:
22.9		 5yf9B-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE

(Aspergillus
clavatus) 		PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp) 		4 VAL A 201
VAL A 194
LYS A 196
PHE A 251
 None
 0.73A 5yf9B-3k5hA:
undetectable		 5yf9B-3k5hA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5p D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Brucella
abortus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 158
VAL A 208
ILE A 222
ASP A 244
 GOL  A 414 ( 4.7A)
None
None
None
 0.89A 5yf9B-3k5pA:
2.2		 5yf9B-3k5pA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
mutans) 		PF01487
(DHquinase_I) 		4 VAL A 174
VAL A 141
LYS A 143
ILE A  58
 None
 0.62A 5yf9B-3l9cA:
undetectable		 5yf9B-3l9cA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 VAL A 566
LYS A 581
PHE A 630
ILE A 719
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
ANP  A 877 (-2.9A)
 0.90A 5yf9B-3lltA:
26.4		 5yf9B-3lltA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 None
 0.45A 5yf9B-3mi9A:
31.0		 5yf9B-3mi9A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  37
LYS A  51
PHE A  98
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-2.8A)
None
MG  A 312 ( 3.3A)
 0.74A 5yf9B-3nizA:
28.6		 5yf9B-3nizA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 VAL A 259
VAL A 129
LYS A 131
ASP A 298
 None
 0.79A 5yf9B-3qdeA:
undetectable		 5yf9B-3qdeA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 VAL A 264
VAL A 129
LYS A 131
ASP A 305
 None
 0.84A 5yf9B-3s4dA:
undetectable		 5yf9B-3s4dA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zcw KINESIN-LIKE PROTEIN
KIF11

(Homo sapiens) 		PF00225
(Kinesin) 		4 VAL A 210
VAL A 204
LYS A 207
ILE A 143
 None
 0.83A 5yf9B-3zcwA:
undetectable		 5yf9B-3zcwA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.50A 5yf9B-3zduA:
26.7		 5yf9B-3zduA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  18
LYS A  33
PHE A  80
ASP A 144
 D15  A 500 (-4.6A)
D15  A 500 ( 4.1A)
D15  A 500 ( 4.3A)
D15  A 500 (-3.7A)
 0.88A 5yf9B-4aguA:
29.3		 5yf9B-4aguA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 LYS A 252
MET A 358
ILE A 368
ASP A 369
 None
 0.90A 5yf9B-4azvA:
9.1		 5yf9B-4azvA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 VAL A 250
MET A 358
ILE A 368
ASP A 369
 None
 0.61A 5yf9B-4azvA:
9.1		 5yf9B-4azvA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 VAL A 250
LYS A 252
MET A 358
ILE A 368
ASP A 369
 ATP  A1450 ( 4.8A)
ATP  A1450 (-2.9A)
ATP  A1450 ( 4.2A)
ATP  A1450 (-4.2A)
MG  A1453 (-2.0A)
 0.92A 5yf9B-4azwA:
9.1		 5yf9B-4azwA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		4 VAL B 158
LYS B 160
ILE B 285
ASP B 286
 None
 0.65A 5yf9B-4ci6B:
18.0		 5yf9B-4ci6B:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evd NEUTROPHIL-ACTIVATIN
G PROTEIN

(Helicobacter
pylori) 		PF00210
(Ferritin) 		4 LYS A  20
PHE A  24
ILE A  95
ASP A  98
 CD  A 215 ( 4.6A)
None
None
None
 0.90A 5yf9B-4evdA:
undetectable		 5yf9B-4evdA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  27
LYS A  43
PHE A  98
ASP A 163
 None
0RS  A 900 (-3.3A)
0RS  A 900 (-4.5A)
0RS  A 900 (-3.6A)
 0.75A 5yf9B-4ez5A:
25.5		 5yf9B-4ez5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		5 VAL A 186
VAL A 198
LYS A 200
ILE A 337
ASP A 338
 None
None
None
None
MG  A 601 (-2.6A)
 1.09A 5yf9B-4ix3A:
20.7		 5yf9B-4ix3A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		5 VAL A  63
LYS A  80
MET A 203
ILE A 211
ASP A 212
 1L7  A 301 ( 4.8A)
1L7  A 301 (-2.8A)
1L7  A 301 ( 4.3A)
1L7  A 301 (-4.4A)
1L7  A 301 (-3.6A)
 0.92A 5yf9B-4jinA:
6.5		 5yf9B-4jinA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A  54
VAL A  67
LYS A  69
PHE A 152
MET A 202
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
None
GNP  A 401 (-3.6A)
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.64A 5yf9B-4jr7A:
44.7		 5yf9B-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrj EFFECTOR NLEH1

(Escherichia
coli) 		no annotation 4 VAL A 147
VAL A 157
LYS A 159
ILE A 257
 ANP  A 301 (-4.2A)
ANP  A 301 (-4.9A)
ANP  A 301 (-3.6A)
ANP  A 301 (-4.2A)
 0.59A 5yf9B-4lrjA:
9.1		 5yf9B-4lrjA:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL E  53
VAL E  66
LYS E  68
PHE E 113
MET E 163
ILE E 174
ASP E 175
 None
 0.57A 5yf9B-4md8E:
36.7		 5yf9B-4md8E:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mir PUTATIVE
UNCHARACTERIZED
PROTEIN

(Brucella
abortus) 		PF09864
(MliC) 		4 VAL A  36
VAL A  38
ILE A  62
ASP A  61
 None
 0.73A 5yf9B-4mirA:
undetectable		 5yf9B-4mirA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  86
LYS A 101
ILE A 212
ASP A 213
 STU  A 601 (-4.8A)
STU  A 601 (-3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
 0.63A 5yf9B-4mvfA:
21.0		 5yf9B-4mvfA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7i 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00459
(Inositol_P) 		4 VAL A 295
VAL A 241
PHE A 195
ILE A 212
 None
 0.77A 5yf9B-4o7iA:
undetectable		 5yf9B-4o7iA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o96 TYPE III EFFECTOR
PROTEIN KINASE

(Escherichia
coli) 		no annotation 5 VAL A 157
VAL A 167
LYS A 169
ILE A 267
ASP A 268
 GOL  A 401 ( 4.9A)
GOL  A 401 (-4.7A)
None
GOL  A 401 (-4.6A)
None
 1.04A 5yf9B-4o96A:
9.2		 5yf9B-4o96A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 801
VAL A 819
LYS A 821
ILE A 945
ASP A 946
 ADP  A1501 (-3.8A)
None
ADP  A1501 (-2.7A)
ADP  A1501 ( 3.9A)
MG  A1503 (-1.7A)
 0.62A 5yf9B-4qpmA:
18.1		 5yf9B-4qpmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32

(Saccharomyces
cerevisiae) 		PF06293
(Kdo) 		4 VAL A  30
LYS A  52
ILE A 181
ASP A 182
 AMP  A 301 (-4.4A)
AMP  A 301 (-2.8A)
AMP  A 301 ( 4.3A)
AMP  A 301 (-3.4A)
 0.53A 5yf9B-4ww7A:
9.6		 5yf9B-4ww7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		4 VAL A 179
LYS A 181
ILE A 292
ASP A 293
 ADP  A 501 (-4.7A)
ADP  A 501 (-2.7A)
ADP  A 501 ( 4.2A)
MG  A 504 (-2.3A)
 0.69A 5yf9B-4y0xA:
17.7		 5yf9B-4y0xA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 173
LYS A 188
PHE A 238
ASP A 307
 4E1  A 505 (-4.5A)
4E1  A 505 (-2.7A)
4E1  A 505 (-4.2A)
4E1  A 505 (-3.6A)
 0.50A 5yf9B-4yljA:
28.0		 5yf9B-4yljA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  42
LYS A  57
ILE A 171
ASP A 172
 ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.5A)
ADP  A 506 ( 2.4A)
 0.62A 5yf9B-4ysjA:
20.2		 5yf9B-4ysjA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgq CELL DIVISION CYCLE
PROTEIN 123

(Schizosaccharomyces
pombe) 		PF07065
(D123) 		4 VAL A  94
LYS A  96
ILE A 238
ASP A 239
 None
 0.82A 5yf9B-4zgqA:
undetectable		 5yf9B-4zgqA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ets 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE

(Staphylococcus
aureus) 		no annotation 4 VAL B 144
VAL B 135
ILE B 131
ASP B 130
 None
 0.84A 5yf9B-5etsB:
undetectable		 5yf9B-5etsB:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		4 VAL A 548
LYS A 563
ILE A 674
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.9A)
None
 0.82A 5yf9B-5ezrA:
22.1		 5yf9B-5ezrA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		4 VAL A 468
VAL A 441
ILE A 264
ASP A 260
 None
None
None
FAD  A 602 (-3.9A)
 0.89A 5yf9B-5glgA:
undetectable		 5yf9B-5glgA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 VAL A  28
LYS A  43
PHE A  90
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
MG  A 302 ( 3.3A)
 0.55A 5yf9B-5hu3A:
27.1		 5yf9B-5hu3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  35
LYS A  52
PHE A  97
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-3.8A)
FMT  A 403 ( 3.3A)
 0.80A 5yf9B-5idnA:
17.4		 5yf9B-5idnA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		4 VAL A  32
LYS A  47
PHE A  94
ASP A 161
 None
 0.76A 5yf9B-5ig1A:
26.2		 5yf9B-5ig1A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 VAL A 132
MET A 152
ILE A 165
ASP A 166
 EDO  A 608 (-4.0A)
None
None
None
 0.90A 5yf9B-5jowA:
undetectable		 5yf9B-5jowA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 163
LYS A 178
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.64A 5yf9B-5lxdA:
27.5		 5yf9B-5lxdA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6p TYROCIDINE SYNTHASE
2

(Brevibacillus
parabrevis) 		no annotation 4 VAL A3251
VAL A3236
PHE A3200
ILE A3170
 None
 0.90A 5yf9B-5m6pA:
undetectable		 5yf9B-5m6pA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  53
VAL A  66
LYS A  68
PHE A 113
ILE A  95
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 4.5A)
 1.39A 5yf9B-5movA:
34.8		 5yf9B-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  53
VAL A  66
LYS A  68
PHE A 113
MET A 163
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 4.0A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.68A 5yf9B-5movA:
34.8		 5yf9B-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 VAL A  52
LYS A  67
ILE A 185
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 ( 4.3A)
None
 0.58A 5yf9B-5turA:
24.3		 5yf9B-5turA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 VAL A  25
LYS A  40
ILE A 149
ASP A 150
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.6A)
7LV  A 401 (-4.2A)
 0.72A 5yf9B-5tvtA:
22.7		 5yf9B-5tvtA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A  25
LYS A  40
MET A 145
ASP A 156
 G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.7A)
G93  A 301 ( 3.2A)
 0.77A 5yf9B-5u94A:
25.2		 5yf9B-5u94A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu2 CAPSID PROTEIN

(Chikungunya
virus) 		no annotation 4 VAL I 243
VAL I 250
LYS I 252
ASP I 161
 None
 0.89A 5yf9B-5vu2I:
undetectable		 5yf9B-5vu2I:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		PF03770
(IPK) 		4 VAL A  73
LYS A  75
ILE A 274
ASP A 275
 None
ADP  A 503 (-2.7A)
ADP  A 503 ( 4.3A)
MG  A 502 (-2.2A)
 0.49A 5yf9B-5w2hA:
6.8		 5yf9B-5w2hA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe9 PUTATIVE ABC
TRANSPORTER,
ATP-BINDING PROTEIN
COMA

(Streptococcus
mutans) 		PF03412
(Peptidase_C39) 		4 VAL A  88
VAL A  86
ILE A 110
ASP A 112
 None
 0.87A 5yf9B-5xe9A:
undetectable		 5yf9B-5xe9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 VAL A  57
LYS A  72
PHE A 117
MET A 167
ILE A 178
 ATP  A 403 (-3.9A)
ATP  A 403 (-3.2A)
None
ATP  A 403 ( 3.7A)
ATP  A 403 ( 4.5A)
 0.87A 5yf9B-5xvuA:
45.5		 5yf9B-5xvuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 VAL A 223
LYS A 238
PHE A 288
ILE A 354
ASP A 355
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.3A)
HRM  A 601 (-3.6A)
HRM  A 601 (-3.7A)
HRM  A 601 (-4.7A)
 0.51A 5yf9B-5y86A:
27.7		 5yf9B-5y86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 4 VAL A 741
LYS A 756
PHE A 813
ASP A 877
 None
None
CJM  A1102 ( 4.4A)
MG  A1101 (-2.5A)
 0.64A 5yf9B-6b3eA:
16.3		 5yf9B-6b3eA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 VAL A 142
LYS A 157
PHE A 230
ASP A 293
 H1N  A 501 (-4.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-3.7A)
H1N  A 501 (-3.5A)
 0.70A 5yf9B-6ccfA:
24.2		 5yf9B-6ccfA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 4 VAL A 179
LYS A 194
PHE A 267
ASP A 330
 F6J  A 501 (-4.6A)
F6J  A 501 (-2.9A)
F6J  A 501 (-3.7A)
F6J  A 501 (-3.8A)
 0.87A 5yf9B-6cmjA:
24.5		 5yf9B-6cmjA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 VAL A 177
LYS A 193
PHE A 243
ASP A 327
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
3NG  A 501 (-3.5A)
3NG  A 501 (-4.5A)
 0.83A 5yf9B-6fylA:
27.6		 5yf9B-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.54A 5yf9B-6fyoA:
27.9		 5yf9B-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-3.5A)
3NG  A 501 (-4.3A)
 0.66A 5yf9B-6fyvA:
27.9		 5yf9B-6fyvA:
undetectable