SIMILAR PATTERNS OF AMINO ACIDS FOR 5YF0_B_SAMB503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 ARG A 424
TYR A 402
GLU A 453
ASP A 504
 None
 1.45A 5yf0B-3gsiA:
2.8		 5yf0B-3gsiA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxk GOOSE-TYPE LYSOZYME
1

(Gadus morhua) 		PF01464
(SLT) 		4 ARG A 103
TYR A 104
GLU A  73
ASP A 176
 None
 1.50A 5yf0B-3gxkA:
0.0		 5yf0B-3gxkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 ARG X 496
TYR X 494
GLU X 317
ASP X 608
 None
 1.47A 5yf0B-3kvnX:
0.4		 5yf0B-3kvnX:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		4 ARG A 471
TYR A 476
GLU A 299
ASP A 297
 None
 1.45A 5yf0B-5txeA:
0.0		 5yf0B-5txeA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 4 ARG A 167
TYR A 181
GLU A 229
ASP A 295
 SAM  A 505 (-4.0A)
None
SAM  A 505 (-2.9A)
SAM  A 505 (-3.6A)
 0.07A 5yf0B-5yf0A:
52.3		 5yf0B-5yf0A:
undetectable