SIMILAR PATTERNS OF AMINO ACIDS FOR 5YF0_A_ACTA504

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		4 VAL A 218
ASN A 219
LYS A 223
TYR A 226
 None
 1.48A 5yf0A-1cjbA:
0.0		 5yf0A-1cjbA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		4 VAL A 121
ASN A 258
LYS A 240
TYR A 239
 None
None
None
WO4  A 701 (-4.2A)
 1.29A 5yf0A-3cfzA:
0.1		 5yf0A-3cfzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		4 VAL A 121
ASN A 255
LYS A 237
TYR A 236
 None
None
None
WO4  A 701 (-4.4A)
 1.28A 5yf0A-3cg1A:
0.6		 5yf0A-3cg1A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg3 UPF0100 PROTEIN
PH0151

(Pyrococcus
horikoshii) 		PF13531
(SBP_bac_11) 		4 VAL A 116
ASN A 250
LYS A 232
TYR A 231
 None
None
None
WO4  A 701 (-4.3A)
 1.22A 5yf0A-3cg3A:
0.7		 5yf0A-3cg3A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2i NADH-CYTOCHROME B5
REDUCTASE 3

(Sus scrofa) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 VAL A  61
ASN A  59
LYS A  97
TYR A 101
 None
None
FAD  A 301 (-4.6A)
None
 1.46A 5yf0A-3w2iA:
3.2		 5yf0A-3w2iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pia AUTOLYSIN E

(Staphylococcus
aureus) 		PF01832
(Glucosaminidase) 		4 VAL A  37
ASN A  38
LYS A 258
TYR A 257
 None
 1.45A 5yf0A-4piaA:
0.0		 5yf0A-4piaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 VAL A 233
ASN A 235
LYS A 230
TYR A 627
 None
 1.45A 5yf0A-4uooA:
0.1		 5yf0A-4uooA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1x LAGLIDADG
ENDONUCLEASE

(Fusarium
graminearum) 		PF00961
(LAGLIDADG_1) 		4 VAL A  72
ASN A  65
LYS A  74
TYR A  73
 None
 0.77A 5yf0A-4z1xA:
0.0		 5yf0A-4z1xA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yf0 -

(-) 		no annotation 4 VAL A 388
ASN A 389
LYS A 395
TYR A 396
 ACT  A 504 (-4.0A)
None
None
ACT  A 504 (-4.7A)
 0.02A 5yf0A-5yf0A:
55.3		 5yf0A-5yf0A:
undetectable