SIMILAR PATTERNS OF AMINO ACIDS FOR 5YCP_A_BRLA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		3 GLY A 183
VAL A 356
MET A 346
 None
 0.47A 5ycpA-1b65A:
0.0		 5ycpA-1b65A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		3 GLY A 166
VAL A 139
MET A 135
 None
 0.58A 5ycpA-1c3lA:
0.0		 5ycpA-1c3lA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 GLY A 397
VAL A 450
MET A 448
 None
 0.63A 5ycpA-1clwA:
undetectable		 5ycpA-1clwA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1col COLICIN A

(Escherichia
coli) 		PF01024
(Colicin) 		3 GLY A 184
VAL A 137
MET A 134
 None
 0.62A 5ycpA-1colA:
0.0		 5ycpA-1colA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 GLY A 206
VAL A 217
MET A 181
 None
 0.46A 5ycpA-1dmsA:
undetectable		 5ycpA-1dmsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		3 GLY A 220
VAL A 175
MET A 244
 None
 0.59A 5ycpA-1hcuA:
0.0		 5ycpA-1hcuA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlv GLUTATHIONE
TRANSFERASE GST1-3

(Anopheles
cracens) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 GLY A 170
VAL A 134
MET A 130
 None
 0.64A 5ycpA-1jlvA:
undetectable		 5ycpA-1jlvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		3 GLY A 217
VAL A 153
MET A 155
 None
 0.63A 5ycpA-1mppA:
undetectable		 5ycpA-1mppA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		3 GLY A 283
VAL A  44
MET A  46
 MA4  A 300 ( 3.9A)
None
None
 0.65A 5ycpA-1n9bA:
0.0		 5ycpA-1n9bA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		3 GLY A 108
VAL A 123
MET A 125
 None
 0.58A 5ycpA-1pz3A:
0.0		 5ycpA-1pz3A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		3 GLY A 481
VAL A 345
MET A 357
 None
 0.63A 5ycpA-1qafA:
undetectable		 5ycpA-1qafA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 GLY A 579
VAL A 543
MET A 593
 A  B  38 ( 4.1A)
None
None
 0.65A 5ycpA-1qf6A:
0.5		 5ycpA-1qf6A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		3 GLY A  99
VAL A 120
MET A 116
 None
 0.64A 5ycpA-1r30A:
undetectable		 5ycpA-1r30A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		3 GLY A 494
VAL A 447
MET A 444
 None
 0.57A 5ycpA-1rh1A:
undetectable		 5ycpA-1rh1A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugs NITRILE HYDRATASE
ALPHA SUBUNIT

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		3 GLY A  51
VAL A 169
MET A 195
 None
 0.54A 5ycpA-1ugsA:
undetectable		 5ycpA-1ugsA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 GLY A 128
VAL A 119
MET A 121
 None
 0.63A 5ycpA-1uiyA:
undetectable		 5ycpA-1uiyA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjc MOBB PROTEIN HOMOLOG

(Geobacillus
stearothermophilus) 		PF03205
(MobB) 		3 GLY A  29
VAL A 162
MET A 159
 None
 0.65A 5ycpA-1xjcA:
undetectable		 5ycpA-1xjcA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLY A 281
VAL A 210
MET A 275
 None
 0.48A 5ycpA-2ag1A:
undetectable		 5ycpA-2ag1A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee7 SPERM FLAGELLAR
PROTEIN 1

(Homo sapiens) 		PF06294
(CH_2) 		3 GLY A  43
VAL A  58
MET A  60
 None
 0.61A 5ycpA-2ee7A:
undetectable		 5ycpA-2ee7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		3 GLY A 111
VAL A  37
MET A  33
 None
 0.55A 5ycpA-2ej5A:
undetectable		 5ycpA-2ej5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		3 GLY A  50
VAL A 355
MET A 168
 DBO  A1001 (-3.7A)
None
None
 0.65A 5ycpA-2ewyA:
undetectable		 5ycpA-2ewyA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		3 GLY A 243
VAL A 355
MET A 168
 DBO  A1001 (-4.2A)
None
None
 0.59A 5ycpA-2ewyA:
undetectable		 5ycpA-2ewyA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLY A 264
VAL A 171
MET A 173
 None
 0.64A 5ycpA-2f7vA:
undetectable		 5ycpA-2f7vA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		3 GLY A 273
VAL A 297
MET A 295
 None
 0.56A 5ycpA-2i99A:
undetectable		 5ycpA-2i99A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igw PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Caenorhabditis
elegans) 		PF00160
(Pro_isomerase) 		3 GLY A  34
VAL A 134
MET A 107
 None
 0.57A 5ycpA-2igwA:
undetectable		 5ycpA-2igwA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 GLY A 168
VAL A 602
MET A 631
 None
 0.61A 5ycpA-2ivfA:
undetectable		 5ycpA-2ivfA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwo MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		3 GLY A1846
VAL A1835
MET A1914
 None
 0.65A 5ycpA-2iwoA:
undetectable		 5ycpA-2iwoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miz M04 IMMUNOEVASIN

(Murid
betaherpesvirus
1) 		PF12216
(m04gp34like) 		3 GLY A  25
VAL A 169
MET A 166
 None
 0.55A 5ycpA-2mizA:
undetectable		 5ycpA-2mizA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oua SERINE PROTEASE

(Nocardiopsis
alba) 		PF00089
(Trypsin) 		3 GLY A  56
VAL A  64
MET A  37
 None
 0.65A 5ycpA-2ouaA:
undetectable		 5ycpA-2ouaA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozz HYPOTHETICAL PROTEIN
YHFZ

(Shigella
flexneri) 		PF14503
(YhfZ_C) 		3 GLY A  29
VAL A  67
MET A  19
 None
 0.63A 5ycpA-2ozzA:
undetectable		 5ycpA-2ozzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4

(Homo sapiens) 		PF01454
(MAGE) 		3 GLY A 153
VAL A 140
MET A 136
 None
 0.59A 5ycpA-2wa0A:
undetectable		 5ycpA-2wa0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE-1 RESTRICTION
ENZYME ECOKI
SPECIFICITY PROTEIN

(Escherichia
coli) 		PF01420
(Methylase_S) 		3 GLY A 295
VAL A 351
MET A 347
 None
 0.64A 5ycpA-2y7cA:
undetectable		 5ycpA-2y7cA:
11.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLY A 284
VAL A 339
MET A 348
 MC5  A   1 ( 4.5A)
MC5  A   1 (-4.6A)
MC5  A   1 ( 4.0A)
 0.21A 5ycpA-3b0qA:
41.9		 5ycpA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		3 GLY A 430
VAL A 372
MET A 403
 None
 0.64A 5ycpA-3bf0A:
undetectable		 5ycpA-3bf0A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		3 GLY A 189
VAL A 278
MET A 274
 None
None
UDP  A 332 ( 4.3A)
 0.52A 5ycpA-3cknA:
undetectable		 5ycpA-3cknA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		3 GLY A  65
VAL A  42
MET A  37
 None
 0.55A 5ycpA-3cwrA:
undetectable		 5ycpA-3cwrA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 GLY A 295
VAL A 193
MET A 184
 None
None
FAD  A 602 (-4.2A)
 0.62A 5ycpA-3djlA:
undetectable		 5ycpA-3djlA:
10.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 GLY D 284
VAL D 339
MET D 348
 PLB  D 701 (-3.3A)
None
PLB  D 701 ( 4.7A)
 0.23A 5ycpA-3dzuD:
38.1		 5ycpA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 GLY A 678
VAL A 703
MET A 666
 None
 0.60A 5ycpA-3eqnA:
undetectable		 5ycpA-3eqnA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3few COLICIN S4

(Escherichia
coli) 		PF01024
(Colicin) 		3 GLY X 479
VAL X 432
MET X 429
 None
 0.56A 5ycpA-3fewX:
undetectable		 5ycpA-3fewX:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gek PUTATIVE
THIOESTERASE YHDA

(Lactococcus
lactis) 		PF03061
(4HBT) 		3 GLY A  50
VAL A  93
MET A  34
 None
 0.65A 5ycpA-3gekA:
undetectable		 5ycpA-3gekA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR

(Chromobacterium
violaceum) 		PF13377
(Peripla_BP_3) 		3 GLY A  91
VAL A 166
MET A 155
 None
 0.41A 5ycpA-3h5oA:
undetectable		 5ycpA-3h5oA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE

(Ruegeria
pomeroyi) 		PF03435
(Sacchrp_dh_NADP) 		3 GLY A  11
VAL A  47
MET A  45
 None
 0.52A 5ycpA-3ic5A:
undetectable		 5ycpA-3ic5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ied HEAT SHOCK PROTEIN

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		3 GLY A 223
VAL A 108
MET A 112
 None
 0.54A 5ycpA-3iedA:
undetectable		 5ycpA-3iedA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 3 GLY A 249
VAL A 282
MET A 305
 None
 0.58A 5ycpA-3iupA:
undetectable		 5ycpA-3iupA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 GLY A 285
VAL A 269
MET A 426
 None
 0.63A 5ycpA-3iwkA:
undetectable		 5ycpA-3iwkA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 GLY 7 119
VAL 7  45
MET 7 110
 NAG  7 404 (-3.6A)
None
None
 0.60A 5ycpA-3j9f7:
undetectable		 5ycpA-3j9f7:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 GLY A 239
VAL A 227
MET A 223
 None
 0.63A 5ycpA-3k96A:
undetectable		 5ycpA-3k96A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		3 GLY A 411
VAL A 402
MET A 425
 None
 0.62A 5ycpA-3l9xA:
undetectable		 5ycpA-3l9xA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		3 GLY A 172
VAL A 354
MET A 346
 None
 0.52A 5ycpA-3nfbA:
undetectable		 5ycpA-3nfbA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		3 GLY A 182
VAL A 271
MET A 267
 None
None
GDD  A 340 (-3.4A)
 0.60A 5ycpA-3o3pA:
undetectable		 5ycpA-3o3pA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY

(Bacteroides
ovatus) 		PF09992
(NAGPA) 		3 GLY A 223
VAL A 129
MET A 309
 None
 0.48A 5ycpA-3ohgA:
undetectable		 5ycpA-3ohgA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rst SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		3 GLY A 168
VAL A 109
MET A 141
 None
 0.63A 5ycpA-3rstA:
undetectable		 5ycpA-3rstA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		3 GLY A 222
VAL A 166
MET A 134
 None
 0.65A 5ycpA-3s5nA:
undetectable		 5ycpA-3s5nA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 3 GLY A 631
VAL A 546
MET A 548
 None
 0.60A 5ycpA-3sbqA:
undetectable		 5ycpA-3sbqA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31

(Homo sapiens) 		PF01798
(Nop) 		3 GLY B 233
VAL B 208
MET B 212
 None
 0.62A 5ycpA-3siuB:
undetectable		 5ycpA-3siuB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugs UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		no annotation 3 GLY B  33
VAL B 173
MET B  11
 None
None
FFT  B 401 (-4.3A)
 0.47A 5ycpA-3ugsB:
undetectable		 5ycpA-3ugsB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyj LYSINE-SPECIFIC
DEMETHYLASE 8

(Homo sapiens) 		PF13621
(Cupin_8) 		3 GLY A 271
VAL A 235
MET A 253
 None
 0.65A 5ycpA-3uyjA:
undetectable		 5ycpA-3uyjA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		3 GLY A  15
VAL A   8
MET A  48
 None
 0.59A 5ycpA-3w7bA:
undetectable		 5ycpA-3w7bA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bva THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE

(Mus musculus) 		PF02423
(OCD_Mu_crystall) 		3 GLY A 272
VAL A 296
MET A 294
 None
 0.63A 5ycpA-4bvaA:
undetectable		 5ycpA-4bvaA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Clostridioides
difficile) 		PF00590
(TP_methylase) 		3 GLY A 180
VAL A 226
MET A 161
 None
 0.62A 5ycpA-4e16A:
undetectable		 5ycpA-4e16A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE

(Scaptomyza
nigrita) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 GLY A 171
VAL A 135
MET A 131
 None
 0.65A 5ycpA-4i97A:
undetectable		 5ycpA-4i97A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A

(Pseudomonas
putida) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 GLY A 388
VAL A 364
MET A 362
 None
 0.66A 5ycpA-4j0qA:
undetectable		 5ycpA-4j0qA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgu COLH PROTEIN

(Hathewaya
histolytica) 		PF00801
(PKD) 		3 GLY A 797
VAL A 838
MET A 854
 None
 0.63A 5ycpA-4jguA:
undetectable		 5ycpA-4jguA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jif INTEGRIN
BETA-1-BINDING
PROTEIN 1
KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens;
Homo sapiens) 		PF10480
(ICAP-1_inte_bdg)
PF16705
(NUDIX_5) 		3 GLY A 118
VAL B 190
MET A 141
 None
 0.57A 5ycpA-4jifA:
undetectable		 5ycpA-4jifA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		3 GLY A 168
VAL A 109
MET A 141
 None
 0.66A 5ycpA-4kwbA:
undetectable		 5ycpA-4kwbA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 GLY A 733
VAL A 543
MET A 540
 None
 0.59A 5ycpA-4lglA:
undetectable		 5ycpA-4lglA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ob1 COBALT-CONTAINING
NITRILE HYDRATASE
SUBUNIT ALPHA

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		3 GLY A  51
VAL A 169
MET A 195
 None
 0.52A 5ycpA-4ob1A:
undetectable		 5ycpA-4ob1A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Homo sapiens) 		PF01163
(RIO1) 		3 GLY A 177
VAL A 276
MET A 269
 None
 0.62A 5ycpA-4otpA:
undetectable		 5ycpA-4otpA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		3 GLY A 219
VAL A 299
MET A 301
 None
 0.59A 5ycpA-4petA:
undetectable		 5ycpA-4petA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyu UBIQUITIN-LIKE
PROTEIN 5

(Homo sapiens) 		PF00240
(ubiquitin) 		3 GLY A  58
VAL A   4
MET A  66
 None
 0.63A 5ycpA-4pyuA:
undetectable		 5ycpA-4pyuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2

(Homo sapiens) 		PF01130
(CD36) 		3 GLY A  78
VAL A 389
MET A 404
 None
 0.60A 5ycpA-4tw0A:
undetectable		 5ycpA-4tw0A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE IRON
PROTEIN 1

(Azotobacter
vinelandii) 		PF00142
(Fer4_NifH) 		3 GLY E 113
VAL E 122
MET E  34
 None
 0.52A 5ycpA-4wzbE:
undetectable		 5ycpA-4wzbE:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
SLIT AND NTRK-LIKE
PROTEIN 2

(Mus musculus;
Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3)
PF13855
(LRR_8) 		3 GLY A 138
VAL B 236
MET B 209
 None
 0.63A 5ycpA-4y61A:
undetectable		 5ycpA-4y61A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 3 GLY A 585
VAL A 489
MET A 556
 CL  A 901 (-3.6A)
None
HEC  A 905 ( 3.8A)
 0.59A 5ycpA-5c2vA:
undetectable		 5ycpA-5c2vA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		3 GLY B 202
VAL B  47
MET B  44
 None
 0.53A 5ycpA-5c5bB:
undetectable		 5ycpA-5c5bB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLY A 359
VAL A 203
MET A 158
 None
 0.59A 5ycpA-5cnxA:
undetectable		 5ycpA-5cnxA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9t DEHYDROASCORBATE
REDUCTASE

(Oryza sativa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 GLY A  18
VAL A   5
MET A  39
 None
 0.53A 5ycpA-5d9tA:
undetectable		 5ycpA-5d9tA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evo DEHYDROASCORBATE
REDUCTASE

(Cenchrus
americanus) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 GLY A  18
VAL A   5
MET A  39
 None
 0.61A 5ycpA-5evoA:
undetectable		 5ycpA-5evoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f67 INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 GLY A 376
VAL A 367
MET A 442
 None
 0.61A 5ycpA-5f67A:
undetectable		 5ycpA-5f67A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 3 GLY A 460
VAL A 493
MET A 510
 None
 0.62A 5ycpA-5f75A:
undetectable		 5ycpA-5f75A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 GLY A 344
VAL A 371
MET A 373
 None
 0.64A 5ycpA-5fi0A:
undetectable		 5ycpA-5fi0A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fna CASPASE-1

(Homo sapiens) 		PF00619
(CARD) 		3 GLY A  23
VAL A  42
MET A  39
 None
 0.52A 5ycpA-5fnaA:
undetectable		 5ycpA-5fnaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 GLY A  55
VAL A  87
MET A  78
 None
 0.65A 5ycpA-5gweA:
undetectable		 5ycpA-5gweA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		3 GLY A 224
VAL A 209
MET A 205
 None
 0.66A 5ycpA-5hh3A:
undetectable		 5ycpA-5hh3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 3 GLY B 117
VAL B  11
MET B  15
 None
 0.61A 5ycpA-5i70B:
undetectable		 5ycpA-5i70B:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		3 GLY A 184
VAL A 273
MET A 269
 3PG  A 401 (-3.3A)
None
3PG  A 401 (-3.5A)
 0.60A 5ycpA-5jqxA:
undetectable		 5ycpA-5jqxA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1

(Rhinovirus C) 		PF00073
(Rhv) 		3 GLY A 205
VAL A 118
MET A 116
 None
 0.66A 5ycpA-5k0uA:
undetectable		 5ycpA-5k0uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		3 GLY A 823
VAL A 304
MET A 302
 None
 0.66A 5ycpA-5l3dA:
undetectable		 5ycpA-5l3dA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 3 GLY A 694
VAL A 667
MET A 660
 None
 0.59A 5ycpA-5n8dA:
undetectable		 5ycpA-5n8dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		3 GLY J 461
VAL J 426
MET J 429
 None
 0.62A 5ycpA-5nilJ:
undetectable		 5ycpA-5nilJ:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 GLY A 368
VAL A  79
MET A  76
 5GP  A 600 ( 3.4A)
None
5GP  A 600 ( 2.9A)
 0.55A 5ycpA-5tc3A:
undetectable		 5ycpA-5tc3A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsb MEMBRANE PROTEIN

(Bordetella
bronchiseptica) 		PF02535
(Zip) 		3 GLY A 136
VAL A 187
MET A 183
 None
 0.56A 5ycpA-5tsbA:
undetectable		 5ycpA-5tsbA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		3 GLY A 317
VAL A 308
MET A 306
 None
FAD  A 501 (-4.1A)
None
 0.62A 5ycpA-5ttkA:
undetectable		 5ycpA-5ttkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		3 GLY A  63
VAL A 143
MET A 145
 None
 0.66A 5ycpA-5ubuA:
undetectable		 5ycpA-5ubuA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 3 GLY A 184
VAL A  47
MET A  55
 None
 0.48A 5ycpA-5ujdA:
undetectable		 5ycpA-5ujdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 GLY A 365
VAL A 150
MET A 154
 None
 0.51A 5ycpA-5uowA:
undetectable		 5ycpA-5uowA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 GLY A 163
VAL A 240
MET A 237
 None
 0.46A 5ycpA-5v7iA:
undetectable		 5ycpA-5v7iA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Chaetomium
thermophilum) 		no annotation 3 GLY A  86
VAL A 162
MET A 160
 None
 0.63A 5ycpA-5w8mA:
undetectable		 5ycpA-5w8mA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 GLY A  28
VAL A  60
MET A  51
 None
 0.64A 5ycpA-5xjnA:
undetectable		 5ycpA-5xjnA:
9.89