SIMILAR PATTERNS OF AMINO ACIDS FOR 5YCP_A_BRLA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN


(Rhinovirus A)
PF00073
(Rhv)
5 PHE 2 189
LEU 2 221
ILE 2 240
LEU 2 183
LEU 2 179
None
1.10A 5ycpA-1c8m2:
undetectable
5ycpA-1c8m2:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)


(Hepacivirus C)
PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD)
5 CYH A 499
LEU A 560
ILE A 542
LEU A 513
LEU A 301
None
1.49A 5ycpA-1cu1A:
0.0
5ycpA-1cu1A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae)
PF00995
(Sec1)
5 PHE A 649
ILE A 175
LEU A 493
LEU A 656
TYR A 489
None
1.45A 5ycpA-1mqsA:
undetectable
5ycpA-1mqsA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE


(Methylophilus
methylotrophus)
PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2)
5 CYH A 348
SER A 271
ILE A 352
LEU A 428
LEU A 437
SF4  A1732 (-2.3A)
None
FMN  A1730 (-4.3A)
None
None
1.45A 5ycpA-1o94A:
0.0
5ycpA-1o94A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ois DNA TOPOISOMERASE I

(Saccharomyces
cerevisiae)
PF02919
(Topoisom_I_N)
5 PHE A 229
CYH A 232
LEU A 177
ILE A 224
LEU A 192
None
1.43A 5ycpA-1oisA:
undetectable
5ycpA-1oisA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)


(Homo sapiens)
PF03810
(IBN_N)
PF13513
(HEAT_EZ)
5 CYH A 765
TYR A 757
LEU A 758
ILE A 804
LEU A 700
None
1.50A 5ycpA-1qgrA:
0.0
5ycpA-1qgrA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE


(Bacillus
subtilis)
PF01238
(PMI_typeI)
5 LEU A 288
ILE A 255
HIS A 293
LEU A  86
TYR A  28
None
1.36A 5ycpA-1qwrA:
undetectable
5ycpA-1qwrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)


(Rhinovirus A)
PF00073
(Rhv)
5 PHE 2 190
LEU 2 222
ILE 2 242
LEU 2 184
LEU 2 180
None
1.15A 5ycpA-1r1a2:
undetectable
5ycpA-1r1a2:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 TYR A 297
LEU A  80
ILE A  17
HIS A 296
LEU A 224
None
1.50A 5ycpA-1tkcA:
undetectable
5ycpA-1tkcA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE


(Thermotoga
maritima)
PF00764
(Arginosuc_synth)
5 PHE A  72
LEU A  86
ILE A 319
MET A 184
LEU A 248
None
1.49A 5ycpA-1vl2A:
0.0
5ycpA-1vl2A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0k HYPOTHETICAL PROTEIN
PA4535


(Pseudomonas
aeruginosa)
PF08682
(DUF1780)
5 PHE A  70
LEU A 147
LEU A 122
LEU A 183
TYR A 164
None
1.34A 5ycpA-1y0kA:
undetectable
5ycpA-1y0kA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE


(Synechococcus
elongatus)
PF00749
(tRNA-synt_1c)
5 PHE A 136
TYR A 121
LEU A 105
HIS A 125
LEU A 128
None
1.48A 5ycpA-2cfoA:
0.0
5ycpA-2cfoA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT


(Homo sapiens)
PF00620
(RhoGAP)
5 PHE A  90
HIS A  69
ILE A  38
LEU A  20
TYR A  12
None
1.42A 5ycpA-2ee4A:
undetectable
5ycpA-2ee4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6s CELL FILAMENTATION
PROTEIN, PUTATIVE


(Helicobacter
pylori)
PF02661
(Fic)
5 SER A   7
ILE A  15
HIS A  35
LEU A  42
TYR A  43
None
1.49A 5ycpA-2f6sA:
undetectable
5ycpA-2f6sA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 SER A 479
LEU A 464
ILE A 504
LEU A 195
TYR A 186
None
1.06A 5ycpA-2g3nA:
undetectable
5ycpA-2g3nA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus)
PF01707
(Peptidase_C9)
5 PHE A 759
HIS A 689
ILE A 698
LEU A 780
TYR A 784
None
1.28A 5ycpA-2hwkA:
undetectable
5ycpA-2hwkA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
5 PHE A 768
SER A 775
LEU A 316
ILE A 730
LEU A 285
None
1.14A 5ycpA-2iukA:
undetectable
5ycpA-2iukA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwb TRANSLATIONALLY-CONT
ROLLED TUMOR PROTEIN
HOMOLOG


(Caenorhabditis
elegans)
PF00838
(TCTP)
5 LEU A   2
ILE A 177
HIS A  74
LEU A  76
LEU A 169
None
1.23A 5ycpA-2kwbA:
undetectable
5ycpA-2kwbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE


(Nostoc
punctiforme)
PF00221
(Lyase_aromatic)
5 HIS A 561
LEU A 566
ILE A 326
LEU A 511
LEU A 287
None
1.44A 5ycpA-2nyfA:
undetectable
5ycpA-2nyfA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
6 CYH A 276
LEU A 321
ILE A 339
HIS A 440
LEU A 460
TYR A 464
735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
1.37A 5ycpA-2p54A:
38.0
5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
0.76A 5ycpA-2p54A:
38.0
5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA


(Homo sapiens)
PF00104
(Hormone_recep)
7 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
LEU A 460
TYR A 464
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
0.90A 5ycpA-2p54A:
38.0
5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA


(Escherichia
coli)
PF01297
(ZnuA)
5 PHE A 217
LEU A 113
LEU A 296
LEU A 184
TYR A 292
None
1.37A 5ycpA-2ps3A:
undetectable
5ycpA-2ps3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1


(Homo sapiens)
PF13513
(HEAT_EZ)
5 CYH A 765
TYR A 757
LEU A 758
ILE A 804
LEU A 700
None
1.50A 5ycpA-2qnaA:
undetectable
5ycpA-2qnaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnr SEPTIN-2

(Homo sapiens)
PF00735
(Septin)
5 PHE A 150
CYH A 149
ILE A 118
LEU A 280
LEU A 287
None
1.42A 5ycpA-2qnrA:
undetectable
5ycpA-2qnrA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg4 UNCHARACTERIZED
PROTEIN


(Oceanicola
granulosus)
PF13759
(2OG-FeII_Oxy_5)
5 PHE A 203
SER A  79
ILE A  72
LEU A 180
TYR A  15
None
1.32A 5ycpA-2rg4A:
undetectable
5ycpA-2rg4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg4 UNCHARACTERIZED
PROTEIN


(Oceanicola
granulosus)
PF13759
(2OG-FeII_Oxy_5)
5 PHE A 203
SER A  79
LEU A  26
LEU A 180
TYR A  15
None
1.42A 5ycpA-2rg4A:
undetectable
5ycpA-2rg4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F


(Drosophila
melanogaster)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
5 PHE A 860
CYH A 791
LEU A 811
MET A 845
LEU A 925
None
1.28A 5ycpA-2x6kA:
undetectable
5ycpA-2x6kA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale)
PF00232
(Glyco_hydro_1)
5 PHE A 493
SER A  38
ILE A 137
HIS A 452
LEU A 432
None
1.21A 5ycpA-3aivA:
undetectable
5ycpA-3aivA:
7.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
12 PHE A 282
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
ILE A 341
MET A 364
HIS A 449
LEU A 453
LEU A 469
TYR A 473
MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
0.46A 5ycpA-3b0qA:
41.9
5ycpA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE


(Thermotoga
maritima)
PF00809
(Pterin_bind)
PF02574
(S-methyl_trans)
5 PHE A 472
LEU A 409
ILE A 536
LEU A 461
LEU A 420
None
1.45A 5ycpA-3bolA:
undetectable
5ycpA-3bolA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780


(Roseovarius
nubinhibens)
PF13759
(2OG-FeII_Oxy_5)
5 PHE A 203
SER A  79
ILE A  72
LEU A 180
TYR A  15
None
1.38A 5ycpA-3bvcA:
undetectable
5ycpA-3bvcA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA


(Homo sapiens)
PF00104
(Hormone_recep)
6 CYH A 285
HIS A 323
LEU A 330
HIS A 449
LEU A 469
TYR A 473
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
0.67A 5ycpA-3d5fA:
37.1
5ycpA-3d5fA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA


(Homo sapiens)
PF00104
(Hormone_recep)
5 PHE A 282
CYH A 285
HIS A 323
LEU A 469
TYR A 473
L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
0.72A 5ycpA-3d5fA:
37.1
5ycpA-3d5fA:
13.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
5 CYH D 285
TYR D 327
LEU D 330
MET D 364
HIS D 449
PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
0.96A 5ycpA-3dzuD:
38.1
5ycpA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
7 PHE D 282
SER D 289
LEU D 330
ILE D 341
MET D 364
LEU D 469
TYR D 473
None
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
None
None
0.73A 5ycpA-3dzuD:
38.1
5ycpA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
7 SER D 289
LEU D 330
ILE D 341
MET D 364
HIS D 449
LEU D 469
TYR D 473
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
None
None
None
0.72A 5ycpA-3dzuD:
38.1
5ycpA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
7 TYR D 327
LEU D 330
ILE D 341
MET D 364
HIS D 449
LEU D 469
TYR D 473
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
None
None
None
0.88A 5ycpA-3dzuD:
38.1
5ycpA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida)
PF14566
(PTPlike_phytase)
5 PHE A 315
TYR A 248
LEU A 129
LEU A 267
TYR A 237
None
None
None
None
EDO  A   8 (-4.3A)
1.43A 5ycpA-3f41A:
undetectable
5ycpA-3f41A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI


(Monomastix sp.
OKE-1)
PF00961
(LAGLIDADG_1)
5 TYR A  82
LEU A  58
ILE A 306
LEU A   7
LEU A  97
None
1.50A 5ycpA-3fd2A:
undetectable
5ycpA-3fd2A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2)
5 SER A 665
LEU A 623
ILE A 686
LEU A 698
TYR A 650
None
1.34A 5ycpA-3ibjA:
undetectable
5ycpA-3ibjA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN


(Bacillus
halodurans)
PF09084
(NMT1)
5 PHE A 294
HIS A  45
LEU A 280
MET A 249
LEU A 219
None
1.47A 5ycpA-3ix1A:
undetectable
5ycpA-3ix1A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula)
PF14765
(PS-DH)
5 PHE A1004
HIS A1164
ILE A1125
LEU A 965
TYR A1161
None
1.40A 5ycpA-3kg9A:
undetectable
5ycpA-3kg9A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh8 MAOC-LIKE
DEHYDRATASE


(Phytophthora
capsici)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N)
5 TYR A 155
LEU A 152
ILE A  89
MET A  81
LEU A   9
None
1.43A 5ycpA-3kh8A:
undetectable
5ycpA-3kh8A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1


(Bacillus
anthracis)
PF00202
(Aminotran_3)
5 PHE A  30
LEU A  11
ILE A  19
LEU A 391
TYR A  57
None
1.29A 5ycpA-3l44A:
undetectable
5ycpA-3l44A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 LEU A 185
ILE A 143
HIS A 114
LEU A 314
TYR A 313
None
1.48A 5ycpA-3mn3A:
undetectable
5ycpA-3mn3A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3


(Homo sapiens;
Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
5 SER A  60
TYR A  52
LEU A  56
ILE A  63
LEU B  86
None
1.39A 5ycpA-3pv6A:
undetectable
5ycpA-3pv6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE


(Synechocystis
sp. PCC 6803)
PF03320
(FBPase_glpX)
5 TYR A 279
LEU A 284
ILE A 228
MET A 132
LEU A 267
None
1.24A 5ycpA-3rplA:
undetectable
5ycpA-3rplA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN


(Leishmania
major)
PF00782
(DSPc)
5 HIS A 111
LEU A  22
MET A   1
LEU A  32
TYR A  55
None
1.45A 5ycpA-3s4oA:
undetectable
5ycpA-3s4oA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb5 METHIONINE
AMINOPEPTIDASE


(Enterococcus
faecalis)
PF00557
(Peptidase_M24)
5 HIS A 233
ILE A  31
LEU A 252
LEU A 130
TYR A 131
None
1.42A 5ycpA-3tb5A:
undetectable
5ycpA-3tb5A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII


(Pseudoxanthomonas
mexicana)
PF10459
(Peptidase_S46)
5 PHE A 227
SER A  73
LEU A  67
LEU A 701
LEU A 668
None
1.28A 5ycpA-3wonA:
undetectable
5ycpA-3wonA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX


(Legionella
pneumophila)
PF02661
(Fic)
PF12796
(Ank_2)
5 PHE A 258
LEU A 347
ILE A 358
LEU A 244
LEU A 272
GOL  A3000 ( 4.3A)
None
None
None
None
1.41A 5ycpA-4berA:
undetectable
5ycpA-4berA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A


(Homo sapiens)
PF00995
(Sec1)
5 SER A 259
ILE A 250
HIS A   4
LEU A   5
LEU A  48
None
1.46A 5ycpA-4bx9A:
undetectable
5ycpA-4bx9A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Yersinia pestis)
PF00202
(Aminotran_3)
5 PHE A  26
LEU A   7
ILE A  15
LEU A 387
TYR A  52
None
1.44A 5ycpA-4e77A:
undetectable
5ycpA-4e77A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori)
PF00491
(Arginase)
5 PHE A 182
LEU A 137
ILE A 195
LEU A 266
LEU A 223
None
1.41A 5ycpA-4g3hA:
undetectable
5ycpA-4g3hA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF15892
(BNR_4)
5 CYH A 117
SER A 106
HIS A 109
LEU A  63
LEU A 114
None
1.44A 5ycpA-4irtA:
undetectable
5ycpA-4irtA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldy AUXIN RESPONSE
FACTOR 1


(Arabidopsis
thaliana)
PF02362
(B3)
PF06507
(Auxin_resp)
5 TYR A  43
LEU A  97
ILE A  80
HIS A  48
LEU A  52
None
1.43A 5ycpA-4ldyA:
undetectable
5ycpA-4ldyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Desulfitobacterium
hafniense)
PF13458
(Peripla_BP_6)
5 PHE A 199
LEU A 212
ILE A 220
LEU A 155
TYR A 151
None
None
None
None
SO4  A 402 ( 4.5A)
1.38A 5ycpA-4mlcA:
undetectable
5ycpA-4mlcA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus)
PF13445
(zf-RING_UBOX)
5 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
None
1.35A 5ycpA-4txaA:
undetectable
5ycpA-4txaA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii)
PF00144
(Beta-lactamase)
5 HIS A 311
TYR A 322
LEU A 333
ILE A 357
LEU A 284
None
1.44A 5ycpA-4u0tA:
undetectable
5ycpA-4u0tA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii)
PF01636
(APH)
5 PHE A 351
LEU A 406
ILE A 439
LEU A 237
LEU A 306
None
1.33A 5ycpA-4u98A:
undetectable
5ycpA-4u98A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN


(Agrobacterium
tumefaciens)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 SER A  22
HIS A 215
ILE A 298
LEU A  71
TYR A  72
None
1.48A 5ycpA-4uphA:
undetectable
5ycpA-4uphA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE


(Ruegeria
pomeroyi)
PF00884
(Sulfatase)
5 HIS A  46
LEU A  20
ILE A 295
LEU A 386
LEU A 365
None
1.48A 5ycpA-4upkA:
undetectable
5ycpA-4upkA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28


(Cytomegalovirus)
PF00001
(7tm_1)
5 CYH A 120
SER A 118
ILE A 158
LEU A  75
TYR A 291
SIN  A 416 ( 4.0A)
None
None
None
None
1.36A 5ycpA-4xt1A:
undetectable
5ycpA-4xt1A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum)
PF00202
(Aminotran_3)
5 PHE A 350
LEU A  60
ILE A 429
HIS A 396
LEU A 370
None
1.38A 5ycpA-4zm4A:
undetectable
5ycpA-4zm4A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
5 PHE A  37
LEU A  82
ILE A 103
HIS A 170
LEU A 203
None
1.28A 5ycpA-5a0tA:
undetectable
5ycpA-5a0tA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE


(Thermosynechococcus
elongatus)
PF03320
(FBPase_glpX)
5 TYR A 280
LEU A 285
ILE A 228
MET A 132
LEU A 268
None
1.31A 5ycpA-5a5lA:
undetectable
5ycpA-5a5lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10)
PF00150
(Cellulase)
PF03442
(CBM_X2)
5 PHE A 272
HIS A 329
LEU A 290
ILE A 284
TYR A  55
None
1.42A 5ycpA-5e0cA:
undetectable
5ycpA-5e0cA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 PHE A 475
LEU A 267
ILE A 480
LEU A 506
LEU A  41
None
1.49A 5ycpA-5eb5A:
undetectable
5ycpA-5eb5A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE


(Trypanosoma
brucei)
PF06325
(PrmA)
5 CYH A 215
LEU A 334
ILE A 221
MET A 254
LEU A 262
None
1.14A 5ycpA-5ekuA:
undetectable
5ycpA-5ekuA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057


(Thermoplasma
acidophilum)
PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2)
5 HIS A 380
ILE A 180
LEU A 385
LEU A 216
TYR A 391
None
1.47A 5ycpA-5h8wA:
undetectable
5ycpA-5h8wA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii)
PF16483
(Glyco_hydro_64)
5 LEU A 200
ILE A 182
HIS A 260
LEU A 262
TYR A 244
None
1.23A 5ycpA-5h9xA:
undetectable
5ycpA-5h9xA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
5 PHE A 218
LEU A 191
ILE A 187
LEU A 202
LEU A 226
None
1.22A 5ycpA-5hvmA:
undetectable
5ycpA-5hvmA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Aspergillus
fumigatus)
PF00982
(Glyco_transf_20)
5 PHE A 218
LEU A 191
ILE A 187
LEU A 202
LEU A 226
None
1.23A 5ycpA-5hvoA:
undetectable
5ycpA-5hvoA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus)
PF00150
(Cellulase)
5 PHE A 314
SER A  18
ILE A 246
LEU A 307
LEU A  49
None
1.42A 5ycpA-5i6sA:
undetectable
5ycpA-5i6sA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus)
PF07859
(Abhydrolase_3)
5 HIS A  82
LEU A  38
ILE A  19
LEU A 116
TYR A 114
None
1.18A 5ycpA-5l2pA:
undetectable
5ycpA-5l2pA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens)
PF07555
(NAGidase)
5 PHE A  60
LEU A 248
ILE A 134
LEU A 328
TYR A 296
None
1.45A 5ycpA-5m7rA:
undetectable
5ycpA-5m7rA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae)
PF13691
(Lactamase_B_4)
5 PHE A 781
CYH A 782
ILE A 468
LEU A 770
LEU A 767
None
1.45A 5ycpA-5mtzA:
undetectable
5ycpA-5mtzA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okd CYTOCHROME C1, HEME
PROTEIN,
MITOCHONDRIAL


(Bos taurus)
no annotation 5 PHE D 189
LEU D 169
ILE D 164
LEU D  51
TYR D  56
None
1.46A 5ycpA-5okdD:
undetectable
5ycpA-5okdD:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE


(Pseudomonas
aeruginosa)
PF00749
(tRNA-synt_1c)
5 LEU A 467
ILE A 416
MET A 438
LEU A 389
LEU A 427
None
1.46A 5ycpA-5tgtA:
undetectable
5ycpA-5tgtA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)


(Burkholderia
vietnamiensis)
PF00982
(Glyco_transf_20)
5 PHE A 177
LEU A 165
ILE A 199
LEU A 108
TYR A 104
None
1.44A 5ycpA-5tvgA:
undetectable
5ycpA-5tvgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN


(Homo sapiens)
PF07555
(NAGidase)
5 PHE A  60
LEU A 248
ILE A 134
LEU A 328
TYR A 296
None
1.45A 5ycpA-5uhkA:
undetectable
5ycpA-5uhkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN


(Lama glama;
Human
betaherpesvirus
5)
no annotation 5 CYH A 120
SER A 118
ILE A 158
LEU A  75
TYR A 291
None
1.35A 5ycpA-5wb1A:
undetectable
5ycpA-5wb1A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3


(Saccharomyces
cerevisiae)
no annotation 5 LEU A  57
ILE A  78
HIS A  45
LEU A 211
TYR A 215
None
1.21A 5ycpA-5xynA:
undetectable
5ycpA-5xynA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9s VV2_1132

(Vibrio
vulnificus)
no annotation 5 SER A 231
ILE A 239
HIS A 250
LEU A 207
TYR A 153
None
None
None
BR  A 402 (-3.8A)
None
1.27A 5ycpA-5y9sA:
undetectable
5ycpA-5y9sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybp PRHA

(Penicillium
brasilianum)
no annotation 5 SER A 232
ILE A  88
LEU A 238
LEU A 150
TYR A 136
None
1.32A 5ycpA-5ybpA:
undetectable
5ycpA-5ybpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B


(Homo sapiens)
no annotation 5 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
None
1.41A 5ycpA-6d0sA:
undetectable
5ycpA-6d0sA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN


(Escherichia
coli)
no annotation 5 PHE L 299
ILE L 315
HIS L 431
LEU L 435
LEU L  96
None
1.00A 5ycpA-6ehsL:
undetectable
5ycpA-6ehsL:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER


(Geobacillus
kaustophilus)
no annotation 5 SER A  68
LEU A  61
ILE A  45
LEU A 431
LEU A 427
None
1.32A 5ycpA-6f34A:
undetectable
5ycpA-6f34A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-)
no annotation 5 HIS W 185
TYR W 245
LEU W 242
ILE W 233
LEU W 278
None
1.24A 5ycpA-6ftxW:
undetectable
5ycpA-6ftxW:
undetectable