SIMILAR PATTERNS OF AMINO ACIDS FOR 5YCP_A_BRLA501_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8m | HUMAN RHINOVIRUS 16COAT PROTEIN (Rhinovirus A) |
PF00073(Rhv) | 5 | PHE 2 189LEU 2 221ILE 2 240LEU 2 183LEU 2 179 | None | 1.10A | 5ycpA-1c8m2:undetectable | 5ycpA-1c8m2:12.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cu1 | PROTEIN(PROTEASE/HELICASENS3) (Hepacivirus C) |
PF02907(Peptidase_S29)PF07652(Flavi_DEAD) | 5 | CYH A 499LEU A 560ILE A 542LEU A 513LEU A 301 | None | 1.49A | 5ycpA-1cu1A:0.0 | 5ycpA-1cu1A:8.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mqs | SLY1 PROTEIN (Saccharomycescerevisiae) |
PF00995(Sec1) | 5 | PHE A 649ILE A 175LEU A 493LEU A 656TYR A 489 | None | 1.45A | 5ycpA-1mqsA:undetectable | 5ycpA-1mqsA:9.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o94 | TRIMETHYLAMINEDEHYDROGENASE (Methylophilusmethylotrophus) |
PF00724(Oxidored_FMN)PF07992(Pyr_redox_2) | 5 | CYH A 348SER A 271ILE A 352LEU A 428LEU A 437 | SF4 A1732 (-2.3A)NoneFMN A1730 (-4.3A)NoneNone | 1.45A | 5ycpA-1o94A:0.0 | 5ycpA-1o94A:9.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ois | DNA TOPOISOMERASE I (Saccharomycescerevisiae) |
PF02919(Topoisom_I_N) | 5 | PHE A 229CYH A 232LEU A 177ILE A 224LEU A 192 | None | 1.43A | 5ycpA-1oisA:undetectable | 5ycpA-1oisA:15.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgr | PROTEIN (IMPORTINBETA SUBUNIT) (Homo sapiens) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | CYH A 765TYR A 757LEU A 758ILE A 804LEU A 700 | None | 1.50A | 5ycpA-1qgrA:0.0 | 5ycpA-1qgrA:7.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qwr | MANNOSE-6-PHOSPHATEISOMERASE (Bacillussubtilis) |
PF01238(PMI_typeI) | 5 | LEU A 288ILE A 255HIS A 293LEU A 86TYR A 28 | None | 1.36A | 5ycpA-1qwrA:undetectable | 5ycpA-1qwrA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r1a | HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP2) (Rhinovirus A) |
PF00073(Rhv) | 5 | PHE 2 190LEU 2 222ILE 2 242LEU 2 184LEU 2 180 | None | 1.15A | 5ycpA-1r1a2:undetectable | 5ycpA-1r1a2:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkc | TRANSKETOLASE (Saccharomycescerevisiae) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | TYR A 297LEU A 80ILE A 17HIS A 296LEU A 224 | None | 1.50A | 5ycpA-1tkcA:undetectable | 5ycpA-1tkcA:7.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl2 | ARGININOSUCCINATESYNTHASE (Thermotogamaritima) |
PF00764(Arginosuc_synth) | 5 | PHE A 72LEU A 86ILE A 319MET A 184LEU A 248 | None | 1.49A | 5ycpA-1vl2A:0.0 | 5ycpA-1vl2A:10.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y0k | HYPOTHETICAL PROTEINPA4535 (Pseudomonasaeruginosa) |
PF08682(DUF1780) | 5 | PHE A 70LEU A 147LEU A 122LEU A 183TYR A 164 | None | 1.34A | 5ycpA-1y0kA:undetectable | 5ycpA-1y0kA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfo | GLUTAMYL-TRNASYNTHETASE (Synechococcuselongatus) |
PF00749(tRNA-synt_1c) | 5 | PHE A 136TYR A 121LEU A 105HIS A 125LEU A 128 | None | 1.48A | 5ycpA-2cfoA:0.0 | 5ycpA-2cfoA:10.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ee4 | RHO GTPASEACTIVATING PROTEIN 5VARIANT (Homo sapiens) |
PF00620(RhoGAP) | 5 | PHE A 90HIS A 69ILE A 38LEU A 20TYR A 12 | None | 1.42A | 5ycpA-2ee4A:undetectable | 5ycpA-2ee4A:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f6s | CELL FILAMENTATIONPROTEIN, PUTATIVE (Helicobacterpylori) |
PF02661(Fic) | 5 | SER A 7ILE A 15HIS A 35LEU A 42TYR A 43 | None | 1.49A | 5ycpA-2f6sA:undetectable | 5ycpA-2f6sA:18.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | SER A 479LEU A 464ILE A 504LEU A 195TYR A 186 | None | 1.06A | 5ycpA-2g3nA:undetectable | 5ycpA-2g3nA:9.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hwk | HELICASE NSP2 (Venezuelanequineencephalitisvirus) |
PF01707(Peptidase_C9) | 5 | PHE A 759HIS A 689ILE A 698LEU A 780TYR A 784 | None | 1.28A | 5ycpA-2hwkA:undetectable | 5ycpA-2hwkA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iuk | SEED LIPOXYGENASE (Glycine max) |
PF00305(Lipoxygenase)PF01477(PLAT) | 5 | PHE A 768SER A 775LEU A 316ILE A 730LEU A 285 | None | 1.14A | 5ycpA-2iukA:undetectable | 5ycpA-2iukA:6.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kwb | TRANSLATIONALLY-CONTROLLED TUMOR PROTEINHOMOLOG (Caenorhabditiselegans) |
PF00838(TCTP) | 5 | LEU A 2ILE A 177HIS A 74LEU A 76LEU A 169 | None | 1.23A | 5ycpA-2kwbA:undetectable | 5ycpA-2kwbA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyf | NOSTOC PUNCTIFORMEPHENYLALANINEAMMONIA LYASE (Nostocpunctiforme) |
PF00221(Lyase_aromatic) | 5 | HIS A 561LEU A 566ILE A 326LEU A 511LEU A 287 | None | 1.44A | 5ycpA-2nyfA:undetectable | 5ycpA-2nyfA:10.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | CYH A 276LEU A 321ILE A 339HIS A 440LEU A 460TYR A 464 | 735 A 469 (-2.9A)735 A 469 ( 4.3A)735 A 469 ( 4.1A)735 A 469 (-4.0A)735 A 469 (-4.3A)735 A 469 (-4.6A) | 1.37A | 5ycpA-2p54A:38.0 | 5ycpA-2p54A:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | CYH A 276SER A 280LEU A 321MET A 355HIS A 440LEU A 460TYR A 464 | 735 A 469 (-2.9A)735 A 469 (-2.8A)735 A 469 ( 4.3A)735 A 469 (-2.9A)735 A 469 (-4.0A)735 A 469 (-4.3A)735 A 469 (-4.6A) | 0.76A | 5ycpA-2p54A:38.0 | 5ycpA-2p54A:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | PHE A 273CYH A 276SER A 280LEU A 321MET A 355LEU A 460TYR A 464 | 735 A 469 (-3.7A)735 A 469 (-2.9A)735 A 469 (-2.8A)735 A 469 ( 4.3A)735 A 469 (-2.9A)735 A 469 (-4.3A)735 A 469 (-4.6A) | 0.90A | 5ycpA-2p54A:38.0 | 5ycpA-2p54A:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ps3 | HIGH-AFFINITY ZINCUPTAKE SYSTEMPROTEIN ZNUA (Escherichiacoli) |
PF01297(ZnuA) | 5 | PHE A 217LEU A 113LEU A 296LEU A 184TYR A 292 | None | 1.37A | 5ycpA-2ps3A:undetectable | 5ycpA-2ps3A:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qna | IMPORTIN SUBUNITBETA-1 (Homo sapiens) |
PF13513(HEAT_EZ) | 5 | CYH A 765TYR A 757LEU A 758ILE A 804LEU A 700 | None | 1.50A | 5ycpA-2qnaA:undetectable | 5ycpA-2qnaA:9.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qnr | SEPTIN-2 (Homo sapiens) |
PF00735(Septin) | 5 | PHE A 150CYH A 149ILE A 118LEU A 280LEU A 287 | None | 1.42A | 5ycpA-2qnrA:undetectable | 5ycpA-2qnrA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rg4 | UNCHARACTERIZEDPROTEIN (Oceanicolagranulosus) |
PF13759(2OG-FeII_Oxy_5) | 5 | PHE A 203SER A 79ILE A 72LEU A 180TYR A 15 | None | 1.32A | 5ycpA-2rg4A:undetectable | 5ycpA-2rg4A:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rg4 | UNCHARACTERIZEDPROTEIN (Oceanicolagranulosus) |
PF13759(2OG-FeII_Oxy_5) | 5 | PHE A 203SER A 79LEU A 26LEU A 180TYR A 15 | None | 1.42A | 5ycpA-2rg4A:undetectable | 5ycpA-2rg4A:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x6k | PHOSPHOTIDYLINOSITOL3 KINASE 59F (Drosophilamelanogaster) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka) | 5 | PHE A 860CYH A 791LEU A 811MET A 845LEU A 925 | None | 1.28A | 5ycpA-2x6kA:undetectable | 5ycpA-2x6kA:9.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aiv | BETA-GLUCOSIDASE (Secale cereale) |
PF00232(Glyco_hydro_1) | 5 | PHE A 493SER A 38ILE A 137HIS A 452LEU A 432 | None | 1.21A | 5ycpA-3aivA:undetectable | 5ycpA-3aivA:7.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | PHE A 282CYH A 285SER A 289HIS A 323TYR A 327LEU A 330ILE A 341MET A 364HIS A 449LEU A 453LEU A 469TYR A 473 | MC5 A 1 (-4.4A)MC5 A 1 (-3.6A)MC5 A 1 (-2.6A)MC5 A 1 (-3.8A)NoneMC5 A 1 (-4.4A)MC5 A 1 (-4.5A)MC5 A 1 (-3.7A)MC5 A 1 (-3.9A)MC5 A 1 (-4.2A)MC5 A 1 (-4.1A)MC5 A 1 (-4.9A) | 0.46A | 5ycpA-3b0qA:41.9 | 5ycpA-3b0qA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bol | 5-METHYLTETRAHYDROFOLATE S-HOMOCYSTEINEMETHYLTRANSFERASE (Thermotogamaritima) |
PF00809(Pterin_bind)PF02574(S-methyl_trans) | 5 | PHE A 472LEU A 409ILE A 536LEU A 461LEU A 420 | None | 1.45A | 5ycpA-3bolA:undetectable | 5ycpA-3bolA:8.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bvc | UNCHARACTERIZEDPROTEIN ISM_01780 (Roseovariusnubinhibens) |
PF13759(2OG-FeII_Oxy_5) | 5 | PHE A 203SER A 79ILE A 72LEU A 180TYR A 15 | None | 1.38A | 5ycpA-3bvcA:undetectable | 5ycpA-3bvcA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d5f | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | CYH A 285HIS A 323LEU A 330HIS A 449LEU A 469TYR A 473 | L41 A 501 (-3.5A)L41 A 501 (-3.8A)L41 A 501 (-4.9A)L41 A 501 (-3.9A)L41 A 501 (-3.8A)L41 A 501 (-4.8A) | 0.67A | 5ycpA-3d5fA:37.1 | 5ycpA-3d5fA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d5f | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR DELTA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | PHE A 282CYH A 285HIS A 323LEU A 469TYR A 473 | L41 A 501 ( 4.9A)L41 A 501 (-3.5A)L41 A 501 (-3.8A)L41 A 501 (-3.8A)L41 A 501 (-4.8A) | 0.72A | 5ycpA-3d5fA:37.1 | 5ycpA-3d5fA:13.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 5 | CYH D 285TYR D 327LEU D 330MET D 364HIS D 449 | PLB D 701 (-3.2A)NonePLB D 701 ( 4.1A)PLB D 701 ( 4.8A)None | 0.96A | 5ycpA-3dzuD:38.1 | 5ycpA-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 7 | PHE D 282SER D 289LEU D 330ILE D 341MET D 364LEU D 469TYR D 473 | NonePLB D 701 ( 3.9A)PLB D 701 ( 4.1A)PLB D 701 (-3.6A)PLB D 701 ( 4.8A)NoneNone | 0.73A | 5ycpA-3dzuD:38.1 | 5ycpA-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 7 | SER D 289LEU D 330ILE D 341MET D 364HIS D 449LEU D 469TYR D 473 | PLB D 701 ( 3.9A)PLB D 701 ( 4.1A)PLB D 701 (-3.6A)PLB D 701 ( 4.8A)NoneNoneNone | 0.72A | 5ycpA-3dzuD:38.1 | 5ycpA-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 7 | TYR D 327LEU D 330ILE D 341MET D 364HIS D 449LEU D 469TYR D 473 | NonePLB D 701 ( 4.1A)PLB D 701 (-3.6A)PLB D 701 ( 4.8A)NoneNoneNone | 0.88A | 5ycpA-3dzuD:38.1 | 5ycpA-3dzuD:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f41 | PHYTASE (Mitsuokellamultacida) |
PF14566(PTPlike_phytase) | 5 | PHE A 315TYR A 248LEU A 129LEU A 267TYR A 237 | NoneNoneNoneNoneEDO A 8 (-4.3A) | 1.43A | 5ycpA-3f41A:undetectable | 5ycpA-3f41A:9.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd2 | SITE-SPECIFIC DNAENDONUCLEASE I-MSOI (Monomastix sp.OKE-1) |
PF00961(LAGLIDADG_1) | 5 | TYR A 82LEU A 58ILE A 306LEU A 7LEU A 97 | None | 1.50A | 5ycpA-3fd2A:undetectable | 5ycpA-3fd2A:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibj | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I)PF01590(GAF)PF13185(GAF_2) | 5 | SER A 665LEU A 623ILE A 686LEU A 698TYR A 650 | None | 1.34A | 5ycpA-3ibjA:undetectable | 5ycpA-3ibjA:8.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ix1 | N-FORMYL-4-AMINO-5-AMINOMETHYL-2-METHYLPYRIMIDINE BINDINGPROTEIN (Bacillushalodurans) |
PF09084(NMT1) | 5 | PHE A 294HIS A 45LEU A 280MET A 249LEU A 219 | None | 1.47A | 5ycpA-3ix1A:undetectable | 5ycpA-3ix1A:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kg9 | CURK (Lyngbyamajuscula) |
PF14765(PS-DH) | 5 | PHE A1004HIS A1164ILE A1125LEU A 965TYR A1161 | None | 1.40A | 5ycpA-3kg9A:undetectable | 5ycpA-3kg9A:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kh8 | MAOC-LIKEDEHYDRATASE (Phytophthoracapsici) |
PF01575(MaoC_dehydratas)PF13452(MaoC_dehydrat_N) | 5 | TYR A 155LEU A 152ILE A 89MET A 81LEU A 9 | None | 1.43A | 5ycpA-3kh8A:undetectable | 5ycpA-3kh8A:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l44 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE1 (Bacillusanthracis) |
PF00202(Aminotran_3) | 5 | PHE A 30LEU A 11ILE A 19LEU A 391TYR A 57 | None | 1.29A | 5ycpA-3l44A:undetectable | 5ycpA-3l44A:11.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mn3 | CARBONCATABOLITE-DEREPRESSING PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | LEU A 185ILE A 143HIS A 114LEU A 314TYR A 313 | None | 1.48A | 5ycpA-3mn3A:undetectable | 5ycpA-3mn3A:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pv6 | IG-LIKEDOMAIN-CONTAININGPROTEINDKFZP686O24166/DKFZP686I21167NATURAL CYTOTOXICITYTRIGGERING RECEPTOR3 (Homo sapiens;Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 5 | SER A 60TYR A 52LEU A 56ILE A 63LEU B 86 | None | 1.39A | 5ycpA-3pv6A:undetectable | 5ycpA-3pv6A:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rpl | D-FRUCTOSE1,6-BISPHOSPHATASECLASS2/SEDOHEPTULOSE1,7-BISPHOSPHATASE (Synechocystissp. PCC 6803) |
PF03320(FBPase_glpX) | 5 | TYR A 279LEU A 284ILE A 228MET A 132LEU A 267 | None | 1.24A | 5ycpA-3rplA:undetectable | 5ycpA-3rplA:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4o | PROTEIN TYROSINEPHOSPHATASE-LIKEPROTEIN (Leishmaniamajor) |
PF00782(DSPc) | 5 | HIS A 111LEU A 22MET A 1LEU A 32TYR A 55 | None | 1.45A | 5ycpA-3s4oA:undetectable | 5ycpA-3s4oA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tb5 | METHIONINEAMINOPEPTIDASE (Enterococcusfaecalis) |
PF00557(Peptidase_M24) | 5 | HIS A 233ILE A 31LEU A 252LEU A 130TYR A 131 | None | 1.42A | 5ycpA-3tb5A:undetectable | 5ycpA-3tb5A:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3won | DIPEPTIDYLAMINOPEPTIDASE BII (Pseudoxanthomonasmexicana) |
PF10459(Peptidase_S46) | 5 | PHE A 227SER A 73LEU A 67LEU A 701LEU A 668 | None | 1.28A | 5ycpA-3wonA:undetectable | 5ycpA-3wonA:8.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ber | PHOSPHOCHOLINETRANSFERASE ANKX (Legionellapneumophila) |
PF02661(Fic)PF12796(Ank_2) | 5 | PHE A 258LEU A 347ILE A 358LEU A 244LEU A 272 | GOL A3000 ( 4.3A)NoneNoneNoneNone | 1.41A | 5ycpA-4berA:undetectable | 5ycpA-4berA:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bx9 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 33A (Homo sapiens) |
PF00995(Sec1) | 5 | SER A 259ILE A 250HIS A 4LEU A 5LEU A 48 | None | 1.46A | 5ycpA-4bx9A:undetectable | 5ycpA-4bx9A:9.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e77 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Yersinia pestis) |
PF00202(Aminotran_3) | 5 | PHE A 26LEU A 7ILE A 15LEU A 387TYR A 52 | None | 1.44A | 5ycpA-4e77A:undetectable | 5ycpA-4e77A:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g3h | ARGINASE (ROCF) (Helicobacterpylori) |
PF00491(Arginase) | 5 | PHE A 182LEU A 137ILE A 195LEU A 266LEU A 223 | None | 1.41A | 5ycpA-4g3hA:undetectable | 5ycpA-4g3hA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4irt | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF15892(BNR_4) | 5 | CYH A 117SER A 106HIS A 109LEU A 63LEU A 114 | None | 1.44A | 5ycpA-4irtA:undetectable | 5ycpA-4irtA:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ldy | AUXIN RESPONSEFACTOR 1 (Arabidopsisthaliana) |
PF02362(B3)PF06507(Auxin_resp) | 5 | TYR A 43LEU A 97ILE A 80HIS A 48LEU A 52 | None | 1.43A | 5ycpA-4ldyA:undetectable | 5ycpA-4ldyA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mlc | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Desulfitobacteriumhafniense) |
PF13458(Peripla_BP_6) | 5 | PHE A 199LEU A 212ILE A 220LEU A 155TYR A 151 | NoneNoneNoneNoneSO4 A 402 ( 4.5A) | 1.38A | 5ycpA-4mlcA:undetectable | 5ycpA-4mlcA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txa | ROQUIN-1 (Mus musculus) |
PF13445(zf-RING_UBOX) | 5 | HIS A 389LEU A 353LEU A 129LEU A 106TYR A 109 | None | 1.35A | 5ycpA-4txaA:undetectable | 5ycpA-4txaA:10.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u0t | ADC-7 BETA-LACTAMASE (Acinetobacterbaumannii) |
PF00144(Beta-lactamase) | 5 | HIS A 311TYR A 322LEU A 333ILE A 357LEU A 284 | None | 1.44A | 5ycpA-4u0tA:undetectable | 5ycpA-4u0tA:12.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u98 | MALTOKINASE (Mycolicibacteriumvanbaalenii) |
PF01636(APH) | 5 | PHE A 351LEU A 406ILE A 439LEU A 237LEU A 306 | None | 1.33A | 5ycpA-4u98A:undetectable | 5ycpA-4u98A:10.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uph | SULFATASE (SULFURICESTER HYDROLASE)PROTEIN (Agrobacteriumtumefaciens) |
PF00884(Sulfatase)PF16347(DUF4976) | 5 | SER A 22HIS A 215ILE A 298LEU A 71TYR A 72 | None | 1.48A | 5ycpA-4uphA:undetectable | 5ycpA-4uphA:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upk | PHOSPHONATEMONOESTER HYDROLASE (Ruegeriapomeroyi) |
PF00884(Sulfatase) | 5 | HIS A 46LEU A 20ILE A 295LEU A 386LEU A 365 | None | 1.48A | 5ycpA-4upkA:undetectable | 5ycpA-4upkA:9.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xt1 | G-PROTEIN COUPLEDRECEPTOR HOMOLOGUS28 (Cytomegalovirus) |
PF00001(7tm_1) | 5 | CYH A 120SER A 118ILE A 158LEU A 75TYR A 291 | SIN A 416 ( 4.0A)NoneNoneNoneNone | 1.36A | 5ycpA-4xt1A:undetectable | 5ycpA-4xt1A:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zm4 | AMINOTRANSFERASE (Streptomycespactum) |
PF00202(Aminotran_3) | 5 | PHE A 350LEU A 60ILE A 429HIS A 396LEU A 370 | None | 1.38A | 5ycpA-4zm4A:undetectable | 5ycpA-4zm4A:9.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0t | RIBONUCLEASE J (Streptomycescoelicolor) |
PF00753(Lactamase_B)PF07521(RMMBL) | 5 | PHE A 37LEU A 82ILE A 103HIS A 170LEU A 203 | None | 1.28A | 5ycpA-5a0tA:undetectable | 5ycpA-5a0tA:9.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5l | D-FRUCTOSE1,6-BISPHOSPHATASECLASS2/SEDOHEPTULOSE1,7-BISPHOSPHATASE (Thermosynechococcuselongatus) |
PF03320(FBPase_glpX) | 5 | TYR A 280LEU A 285ILE A 228MET A 132LEU A 268 | None | 1.31A | 5ycpA-5a5lA:undetectable | 5ycpA-5a5lA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e0c | CELLULASE (Bacillus sp.BG-CS10) |
PF00150(Cellulase)PF03442(CBM_X2) | 5 | PHE A 272HIS A 329LEU A 290ILE A 284TYR A 55 | None | 1.42A | 5ycpA-5e0cA:undetectable | 5ycpA-5e0cA:8.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eb5 | HNL ISOENZYME 5 (Prunus dulcis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | PHE A 475LEU A 267ILE A 480LEU A 506LEU A 41 | None | 1.49A | 5ycpA-5eb5A:undetectable | 5ycpA-5eb5A:9.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eku | ARGININEN-METHYLTRANSFERASE,PUTATIVE (Trypanosomabrucei) |
PF06325(PrmA) | 5 | CYH A 215LEU A 334ILE A 221MET A 254LEU A 262 | None | 1.14A | 5ycpA-5ekuA:undetectable | 5ycpA-5ekuA:11.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h8w | ATP-DEPENDENT DNAHELICASE TA0057 (Thermoplasmaacidophilum) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 5 | HIS A 380ILE A 180LEU A 385LEU A 216TYR A 391 | None | 1.47A | 5ycpA-5h8wA:undetectable | 5ycpA-5h8wA:11.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h9x | BETA-1,3-GLUCANASE (Paenibacillusbarengoltzii) |
PF16483(Glyco_hydro_64) | 5 | LEU A 200ILE A 182HIS A 260LEU A 262TYR A 244 | None | 1.23A | 5ycpA-5h9xA:undetectable | 5ycpA-5h9xA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvm | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Aspergillusfumigatus) |
PF00982(Glyco_transf_20) | 5 | PHE A 218LEU A 191ILE A 187LEU A 202LEU A 226 | None | 1.22A | 5ycpA-5hvmA:undetectable | 5ycpA-5hvmA:10.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvo | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Aspergillusfumigatus) |
PF00982(Glyco_transf_20) | 5 | PHE A 218LEU A 191ILE A 187LEU A 202LEU A 226 | None | 1.23A | 5ycpA-5hvoA:undetectable | 5ycpA-5hvoA:10.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i6s | ENDOGLUCANASE (Talaromycesverruculosus) |
PF00150(Cellulase) | 5 | PHE A 314SER A 18ILE A 246LEU A 307LEU A 49 | None | 1.42A | 5ycpA-5i6sA:undetectable | 5ycpA-5i6sA:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l2p | ARYLESTERASE (Sulfolobussolfataricus) |
PF07859(Abhydrolase_3) | 5 | HIS A 82LEU A 38ILE A 19LEU A 116TYR A 114 | None | 1.18A | 5ycpA-5l2pA:undetectable | 5ycpA-5l2pA:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m7r | PROTEIN O-GLCNACASE (Homo sapiens) |
PF07555(NAGidase) | 5 | PHE A 60LEU A 248ILE A 134LEU A 328TYR A 296 | None | 1.45A | 5ycpA-5m7rA:undetectable | 5ycpA-5m7rA:7.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mtz | RIBONUCLEASE Z (Saccharomycescerevisiae) |
PF13691(Lactamase_B_4) | 5 | PHE A 781CYH A 782ILE A 468LEU A 770LEU A 767 | None | 1.45A | 5ycpA-5mtzA:undetectable | 5ycpA-5mtzA:6.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5okd | CYTOCHROME C1, HEMEPROTEIN,MITOCHONDRIAL (Bos taurus) |
no annotation | 5 | PHE D 189LEU D 169ILE D 164LEU D 51TYR D 56 | None | 1.46A | 5ycpA-5okdD:undetectable | 5ycpA-5okdD:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tgt | GLUTAMATE--TRNALIGASE (Pseudomonasaeruginosa) |
PF00749(tRNA-synt_1c) | 5 | LEU A 467ILE A 416MET A 438LEU A 389LEU A 427 | None | 1.46A | 5ycpA-5tgtA:undetectable | 5ycpA-5tgtA:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tvg | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE(UDP-FORMING) (Burkholderiavietnamiensis) |
PF00982(Glyco_transf_20) | 5 | PHE A 177LEU A 165ILE A 199LEU A 108TYR A 104 | None | 1.44A | 5ycpA-5tvgA:undetectable | 5ycpA-5tvgA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uhk | O-GLCNACASETIM-BARREL DOMAIN (Homo sapiens) |
PF07555(NAGidase) | 5 | PHE A 60LEU A 248ILE A 134LEU A 328TYR A 296 | None | 1.45A | 5ycpA-5uhkA:undetectable | 5ycpA-5uhkA:15.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wb1 | ENVELOPE PROTEINUS28, NANOBODY 7FUSION PROTEIN (Lama glama;Humanbetaherpesvirus5) |
no annotation | 5 | CYH A 120SER A 118ILE A 158LEU A 75TYR A 291 | None | 1.35A | 5ycpA-5wb1A:undetectable | 5ycpA-5wb1A:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xyn | PLATINUM SENSITIVITYPROTEIN 3 (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 57ILE A 78HIS A 45LEU A 211TYR A 215 | None | 1.21A | 5ycpA-5xynA:undetectable | 5ycpA-5xynA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y9s | VV2_1132 (Vibriovulnificus) |
no annotation | 5 | SER A 231ILE A 239HIS A 250LEU A 207TYR A 153 | NoneNoneNone BR A 402 (-3.8A)None | 1.27A | 5ycpA-5y9sA:undetectable | 5ycpA-5y9sA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ybp | PRHA (Penicilliumbrasilianum) |
no annotation | 5 | SER A 232ILE A 88LEU A 238LEU A 150TYR A 136 | None | 1.32A | 5ycpA-5ybpA:undetectable | 5ycpA-5ybpA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d0s | TBC1 DOMAIN FAMILYMEMBER 22B (Homo sapiens) |
no annotation | 5 | CYH A 445TYR A 430MET A 410LEU A 418LEU A 485 | None | 1.41A | 5ycpA-6d0sA:undetectable | 5ycpA-6d0sA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ehs | HYDROGENASE-2 LARGECHAIN (Escherichiacoli) |
no annotation | 5 | PHE L 299ILE L 315HIS L 431LEU L 435LEU L 96 | None | 1.00A | 5ycpA-6ehsL:undetectable | 5ycpA-6ehsL:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f34 | AMINO ACIDTRANSPORTER (Geobacilluskaustophilus) |
no annotation | 5 | SER A 68LEU A 61ILE A 45LEU A 431LEU A 427 | None | 1.32A | 5ycpA-6f34A:undetectable | 5ycpA-6f34A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ftx | - (-) |
no annotation | 5 | HIS W 185TYR W 245LEU W 242ILE W 233LEU W 278 | None | 1.24A | 5ycpA-6ftxW:undetectable | 5ycpA-6ftxW:undetectable |