SIMILAR PATTERNS OF AMINO ACIDS FOR 5YCP_A_BRLA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN

(Rhinovirus A) 		PF00073
(Rhv) 		5 PHE 2 189
LEU 2 221
ILE 2 240
LEU 2 183
LEU 2 179
 None
 1.10A 5ycpA-1c8m2:
undetectable		 5ycpA-1c8m2:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 CYH A 499
LEU A 560
ILE A 542
LEU A 513
LEU A 301
 None
 1.49A 5ycpA-1cu1A:
0.0		 5ycpA-1cu1A:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		5 PHE A 649
ILE A 175
LEU A 493
LEU A 656
TYR A 489
 None
 1.45A 5ycpA-1mqsA:
undetectable		 5ycpA-1mqsA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 CYH A 348
SER A 271
ILE A 352
LEU A 428
LEU A 437
 SF4  A1732 (-2.3A)
None
FMN  A1730 (-4.3A)
None
None
 1.45A 5ycpA-1o94A:
0.0		 5ycpA-1o94A:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ois DNA TOPOISOMERASE I

(Saccharomyces
cerevisiae) 		PF02919
(Topoisom_I_N) 		5 PHE A 229
CYH A 232
LEU A 177
ILE A 224
LEU A 192
 None
 1.43A 5ycpA-1oisA:
undetectable		 5ycpA-1oisA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 CYH A 765
TYR A 757
LEU A 758
ILE A 804
LEU A 700
 None
 1.50A 5ycpA-1qgrA:
0.0		 5ycpA-1qgrA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		5 LEU A 288
ILE A 255
HIS A 293
LEU A  86
TYR A  28
 None
 1.36A 5ycpA-1qwrA:
undetectable		 5ycpA-1qwrA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A) 		PF00073
(Rhv) 		5 PHE 2 190
LEU 2 222
ILE 2 242
LEU 2 184
LEU 2 180
 None
 1.15A 5ycpA-1r1a2:
undetectable		 5ycpA-1r1a2:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 TYR A 297
LEU A  80
ILE A  17
HIS A 296
LEU A 224
 None
 1.50A 5ycpA-1tkcA:
undetectable		 5ycpA-1tkcA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl2 ARGININOSUCCINATE
SYNTHASE

(Thermotoga
maritima) 		PF00764
(Arginosuc_synth) 		5 PHE A  72
LEU A  86
ILE A 319
MET A 184
LEU A 248
 None
 1.49A 5ycpA-1vl2A:
0.0		 5ycpA-1vl2A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0k HYPOTHETICAL PROTEIN
PA4535

(Pseudomonas
aeruginosa) 		PF08682
(DUF1780) 		5 PHE A  70
LEU A 147
LEU A 122
LEU A 183
TYR A 164
 None
 1.34A 5ycpA-1y0kA:
undetectable		 5ycpA-1y0kA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		5 PHE A 136
TYR A 121
LEU A 105
HIS A 125
LEU A 128
 None
 1.48A 5ycpA-2cfoA:
0.0		 5ycpA-2cfoA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT

(Homo sapiens) 		PF00620
(RhoGAP) 		5 PHE A  90
HIS A  69
ILE A  38
LEU A  20
TYR A  12
 None
 1.42A 5ycpA-2ee4A:
undetectable		 5ycpA-2ee4A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6s CELL FILAMENTATION
PROTEIN, PUTATIVE

(Helicobacter
pylori) 		PF02661
(Fic) 		5 SER A   7
ILE A  15
HIS A  35
LEU A  42
TYR A  43
 None
 1.49A 5ycpA-2f6sA:
undetectable		 5ycpA-2f6sA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 SER A 479
LEU A 464
ILE A 504
LEU A 195
TYR A 186
 None
 1.06A 5ycpA-2g3nA:
undetectable		 5ycpA-2g3nA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hwk HELICASE NSP2

(Venezuelan
equine
encephalitis
virus) 		PF01707
(Peptidase_C9) 		5 PHE A 759
HIS A 689
ILE A 698
LEU A 780
TYR A 784
 None
 1.28A 5ycpA-2hwkA:
undetectable		 5ycpA-2hwkA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 PHE A 768
SER A 775
LEU A 316
ILE A 730
LEU A 285
 None
 1.14A 5ycpA-2iukA:
undetectable		 5ycpA-2iukA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kwb TRANSLATIONALLY-CONT
ROLLED TUMOR PROTEIN
HOMOLOG

(Caenorhabditis
elegans) 		PF00838
(TCTP) 		5 LEU A   2
ILE A 177
HIS A  74
LEU A  76
LEU A 169
 None
 1.23A 5ycpA-2kwbA:
undetectable		 5ycpA-2kwbA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		5 HIS A 561
LEU A 566
ILE A 326
LEU A 511
LEU A 287
 None
 1.44A 5ycpA-2nyfA:
undetectable		 5ycpA-2nyfA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 276
LEU A 321
ILE A 339
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 1.37A 5ycpA-2p54A:
38.0		 5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.76A 5ycpA-2p54A:
38.0		 5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.90A 5ycpA-2p54A:
38.0		 5ycpA-2p54A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		5 PHE A 217
LEU A 113
LEU A 296
LEU A 184
TYR A 292
 None
 1.37A 5ycpA-2ps3A:
undetectable		 5ycpA-2ps3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		5 CYH A 765
TYR A 757
LEU A 758
ILE A 804
LEU A 700
 None
 1.50A 5ycpA-2qnaA:
undetectable		 5ycpA-2qnaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnr SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		5 PHE A 150
CYH A 149
ILE A 118
LEU A 280
LEU A 287
 None
 1.42A 5ycpA-2qnrA:
undetectable		 5ycpA-2qnrA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg4 UNCHARACTERIZED
PROTEIN

(Oceanicola
granulosus) 		PF13759
(2OG-FeII_Oxy_5) 		5 PHE A 203
SER A  79
ILE A  72
LEU A 180
TYR A  15
 None
 1.32A 5ycpA-2rg4A:
undetectable		 5ycpA-2rg4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rg4 UNCHARACTERIZED
PROTEIN

(Oceanicola
granulosus) 		PF13759
(2OG-FeII_Oxy_5) 		5 PHE A 203
SER A  79
LEU A  26
LEU A 180
TYR A  15
 None
 1.42A 5ycpA-2rg4A:
undetectable		 5ycpA-2rg4A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 PHE A 860
CYH A 791
LEU A 811
MET A 845
LEU A 925
 None
 1.28A 5ycpA-2x6kA:
undetectable		 5ycpA-2x6kA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		5 PHE A 493
SER A  38
ILE A 137
HIS A 452
LEU A 432
 None
 1.21A 5ycpA-3aivA:
undetectable		 5ycpA-3aivA:
7.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 PHE A 282
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
ILE A 341
MET A 364
HIS A 449
LEU A 453
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.46A 5ycpA-3b0qA:
41.9		 5ycpA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 PHE A 472
LEU A 409
ILE A 536
LEU A 461
LEU A 420
 None
 1.45A 5ycpA-3bolA:
undetectable		 5ycpA-3bolA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvc UNCHARACTERIZED
PROTEIN ISM_01780

(Roseovarius
nubinhibens) 		PF13759
(2OG-FeII_Oxy_5) 		5 PHE A 203
SER A  79
ILE A  72
LEU A 180
TYR A  15
 None
 1.38A 5ycpA-3bvcA:
undetectable		 5ycpA-3bvcA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
HIS A 323
LEU A 330
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.67A 5ycpA-3d5fA:
37.1		 5ycpA-3d5fA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 282
CYH A 285
HIS A 323
LEU A 469
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.72A 5ycpA-3d5fA:
37.1		 5ycpA-3d5fA:
13.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH D 285
TYR D 327
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 0.96A 5ycpA-3dzuD:
38.1		 5ycpA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 PHE D 282
SER D 289
LEU D 330
ILE D 341
MET D 364
LEU D 469
TYR D 473
 None
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
None
None
 0.73A 5ycpA-3dzuD:
38.1		 5ycpA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 SER D 289
LEU D 330
ILE D 341
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
None
None
None
 0.72A 5ycpA-3dzuD:
38.1		 5ycpA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 TYR D 327
LEU D 330
ILE D 341
MET D 364
HIS D 449
LEU D 469
TYR D 473
 None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.8A)
None
None
None
 0.88A 5ycpA-3dzuD:
38.1		 5ycpA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		5 PHE A 315
TYR A 248
LEU A 129
LEU A 267
TYR A 237
 None
None
None
None
EDO  A   8 (-4.3A)
 1.43A 5ycpA-3f41A:
undetectable		 5ycpA-3f41A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd2 SITE-SPECIFIC DNA
ENDONUCLEASE I-MSOI

(Monomastix sp.
OKE-1) 		PF00961
(LAGLIDADG_1) 		5 TYR A  82
LEU A  58
ILE A 306
LEU A   7
LEU A  97
 None
 1.50A 5ycpA-3fd2A:
undetectable		 5ycpA-3fd2A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 SER A 665
LEU A 623
ILE A 686
LEU A 698
TYR A 650
 None
 1.34A 5ycpA-3ibjA:
undetectable		 5ycpA-3ibjA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 PHE A 294
HIS A  45
LEU A 280
MET A 249
LEU A 219
 None
 1.47A 5ycpA-3ix1A:
undetectable		 5ycpA-3ix1A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 PHE A1004
HIS A1164
ILE A1125
LEU A 965
TYR A1161
 None
 1.40A 5ycpA-3kg9A:
undetectable		 5ycpA-3kg9A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 TYR A 155
LEU A 152
ILE A  89
MET A  81
LEU A   9
 None
 1.43A 5ycpA-3kh8A:
undetectable		 5ycpA-3kh8A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 PHE A  30
LEU A  11
ILE A  19
LEU A 391
TYR A  57
 None
 1.29A 5ycpA-3l44A:
undetectable		 5ycpA-3l44A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 185
ILE A 143
HIS A 114
LEU A 314
TYR A 313
 None
 1.48A 5ycpA-3mn3A:
undetectable		 5ycpA-3mn3A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv6 IG-LIKE
DOMAIN-CONTAINING
PROTEIN
DKFZP686O24166/DKFZP
686I21167
NATURAL CYTOTOXICITY
TRIGGERING RECEPTOR
3

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER A  60
TYR A  52
LEU A  56
ILE A  63
LEU B  86
 None
 1.39A 5ycpA-3pv6A:
undetectable		 5ycpA-3pv6A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		5 TYR A 279
LEU A 284
ILE A 228
MET A 132
LEU A 267
 None
 1.24A 5ycpA-3rplA:
undetectable		 5ycpA-3rplA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN

(Leishmania
major) 		PF00782
(DSPc) 		5 HIS A 111
LEU A  22
MET A   1
LEU A  32
TYR A  55
 None
 1.45A 5ycpA-3s4oA:
undetectable		 5ycpA-3s4oA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb5 METHIONINE
AMINOPEPTIDASE

(Enterococcus
faecalis) 		PF00557
(Peptidase_M24) 		5 HIS A 233
ILE A  31
LEU A 252
LEU A 130
TYR A 131
 None
 1.42A 5ycpA-3tb5A:
undetectable		 5ycpA-3tb5A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		5 PHE A 227
SER A  73
LEU A  67
LEU A 701
LEU A 668
 None
 1.28A 5ycpA-3wonA:
undetectable		 5ycpA-3wonA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ber PHOSPHOCHOLINE
TRANSFERASE ANKX

(Legionella
pneumophila) 		PF02661
(Fic)
PF12796
(Ank_2) 		5 PHE A 258
LEU A 347
ILE A 358
LEU A 244
LEU A 272
 GOL  A3000 ( 4.3A)
None
None
None
None
 1.41A 5ycpA-4berA:
undetectable		 5ycpA-4berA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		5 SER A 259
ILE A 250
HIS A   4
LEU A   5
LEU A  48
 None
 1.46A 5ycpA-4bx9A:
undetectable		 5ycpA-4bx9A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e77 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Yersinia pestis) 		PF00202
(Aminotran_3) 		5 PHE A  26
LEU A   7
ILE A  15
LEU A 387
TYR A  52
 None
 1.44A 5ycpA-4e77A:
undetectable		 5ycpA-4e77A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		5 PHE A 182
LEU A 137
ILE A 195
LEU A 266
LEU A 223
 None
 1.41A 5ycpA-4g3hA:
undetectable		 5ycpA-4g3hA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		5 CYH A 117
SER A 106
HIS A 109
LEU A  63
LEU A 114
 None
 1.44A 5ycpA-4irtA:
undetectable		 5ycpA-4irtA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldy AUXIN RESPONSE
FACTOR 1

(Arabidopsis
thaliana) 		PF02362
(B3)
PF06507
(Auxin_resp) 		5 TYR A  43
LEU A  97
ILE A  80
HIS A  48
LEU A  52
 None
 1.43A 5ycpA-4ldyA:
undetectable		 5ycpA-4ldyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlc EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfitobacterium
hafniense) 		PF13458
(Peripla_BP_6) 		5 PHE A 199
LEU A 212
ILE A 220
LEU A 155
TYR A 151
 None
None
None
None
SO4  A 402 ( 4.5A)
 1.38A 5ycpA-4mlcA:
undetectable		 5ycpA-4mlcA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.35A 5ycpA-4txaA:
undetectable		 5ycpA-4txaA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u0t ADC-7 BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00144
(Beta-lactamase) 		5 HIS A 311
TYR A 322
LEU A 333
ILE A 357
LEU A 284
 None
 1.44A 5ycpA-4u0tA:
undetectable		 5ycpA-4u0tA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		5 PHE A 351
LEU A 406
ILE A 439
LEU A 237
LEU A 306
 None
 1.33A 5ycpA-4u98A:
undetectable		 5ycpA-4u98A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN

(Agrobacterium
tumefaciens) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 SER A  22
HIS A 215
ILE A 298
LEU A  71
TYR A  72
 None
 1.48A 5ycpA-4uphA:
undetectable		 5ycpA-4uphA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		5 HIS A  46
LEU A  20
ILE A 295
LEU A 386
LEU A 365
 None
 1.48A 5ycpA-4upkA:
undetectable		 5ycpA-4upkA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt1 G-PROTEIN COUPLED
RECEPTOR HOMOLOG
US28

(Cytomegalovirus) 		PF00001
(7tm_1) 		5 CYH A 120
SER A 118
ILE A 158
LEU A  75
TYR A 291
 SIN  A 416 ( 4.0A)
None
None
None
None
 1.36A 5ycpA-4xt1A:
undetectable		 5ycpA-4xt1A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		5 PHE A 350
LEU A  60
ILE A 429
HIS A 396
LEU A 370
 None
 1.38A 5ycpA-4zm4A:
undetectable		 5ycpA-4zm4A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 PHE A  37
LEU A  82
ILE A 103
HIS A 170
LEU A 203
 None
 1.28A 5ycpA-5a0tA:
undetectable		 5ycpA-5a0tA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Thermosynechococcus
elongatus) 		PF03320
(FBPase_glpX) 		5 TYR A 280
LEU A 285
ILE A 228
MET A 132
LEU A 268
 None
 1.31A 5ycpA-5a5lA:
undetectable		 5ycpA-5a5lA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 PHE A 272
HIS A 329
LEU A 290
ILE A 284
TYR A  55
 None
 1.42A 5ycpA-5e0cA:
undetectable		 5ycpA-5e0cA:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 PHE A 475
LEU A 267
ILE A 480
LEU A 506
LEU A  41
 None
 1.49A 5ycpA-5eb5A:
undetectable		 5ycpA-5eb5A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 CYH A 215
LEU A 334
ILE A 221
MET A 254
LEU A 262
 None
 1.14A 5ycpA-5ekuA:
undetectable		 5ycpA-5ekuA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		5 HIS A 380
ILE A 180
LEU A 385
LEU A 216
TYR A 391
 None
 1.47A 5ycpA-5h8wA:
undetectable		 5ycpA-5h8wA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		5 LEU A 200
ILE A 182
HIS A 260
LEU A 262
TYR A 244
 None
 1.23A 5ycpA-5h9xA:
undetectable		 5ycpA-5h9xA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		5 PHE A 218
LEU A 191
ILE A 187
LEU A 202
LEU A 226
 None
 1.22A 5ycpA-5hvmA:
undetectable		 5ycpA-5hvmA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvo ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		5 PHE A 218
LEU A 191
ILE A 187
LEU A 202
LEU A 226
 None
 1.23A 5ycpA-5hvoA:
undetectable		 5ycpA-5hvoA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus) 		PF00150
(Cellulase) 		5 PHE A 314
SER A  18
ILE A 246
LEU A 307
LEU A  49
 None
 1.42A 5ycpA-5i6sA:
undetectable		 5ycpA-5i6sA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 HIS A  82
LEU A  38
ILE A  19
LEU A 116
TYR A 114
 None
 1.18A 5ycpA-5l2pA:
undetectable		 5ycpA-5l2pA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		5 PHE A  60
LEU A 248
ILE A 134
LEU A 328
TYR A 296
 None
 1.45A 5ycpA-5m7rA:
undetectable		 5ycpA-5m7rA:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtz RIBONUCLEASE Z

(Saccharomyces
cerevisiae) 		PF13691
(Lactamase_B_4) 		5 PHE A 781
CYH A 782
ILE A 468
LEU A 770
LEU A 767
 None
 1.45A 5ycpA-5mtzA:
undetectable		 5ycpA-5mtzA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okd CYTOCHROME C1, HEME
PROTEIN,
MITOCHONDRIAL

(Bos taurus) 		no annotation 5 PHE D 189
LEU D 169
ILE D 164
LEU D  51
TYR D  56
 None
 1.46A 5ycpA-5okdD:
undetectable		 5ycpA-5okdD:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c) 		5 LEU A 467
ILE A 416
MET A 438
LEU A 389
LEU A 427
 None
 1.46A 5ycpA-5tgtA:
undetectable		 5ycpA-5tgtA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		5 PHE A 177
LEU A 165
ILE A 199
LEU A 108
TYR A 104
 None
 1.44A 5ycpA-5tvgA:
undetectable		 5ycpA-5tvgA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhk O-GLCNACASE
TIM-BARREL DOMAIN

(Homo sapiens) 		PF07555
(NAGidase) 		5 PHE A  60
LEU A 248
ILE A 134
LEU A 328
TYR A 296
 None
 1.45A 5ycpA-5uhkA:
undetectable		 5ycpA-5uhkA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb1 ENVELOPE PROTEIN
US28, NANOBODY 7
FUSION PROTEIN

(Lama glama;
Human
betaherpesvirus
5) 		no annotation 5 CYH A 120
SER A 118
ILE A 158
LEU A  75
TYR A 291
 None
 1.35A 5ycpA-5wb1A:
undetectable		 5ycpA-5wb1A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyn PLATINUM SENSITIVITY
PROTEIN 3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  57
ILE A  78
HIS A  45
LEU A 211
TYR A 215
 None
 1.21A 5ycpA-5xynA:
undetectable		 5ycpA-5xynA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9s VV2_1132

(Vibrio
vulnificus) 		no annotation 5 SER A 231
ILE A 239
HIS A 250
LEU A 207
TYR A 153
 None
None
None
BR  A 402 (-3.8A)
None
 1.27A 5ycpA-5y9sA:
undetectable		 5ycpA-5y9sA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybp PRHA

(Penicillium
brasilianum) 		no annotation 5 SER A 232
ILE A  88
LEU A 238
LEU A 150
TYR A 136
 None
 1.32A 5ycpA-5ybpA:
undetectable		 5ycpA-5ybpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 5 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.41A 5ycpA-6d0sA:
undetectable		 5ycpA-6d0sA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 PHE L 299
ILE L 315
HIS L 431
LEU L 435
LEU L  96
 None
 1.00A 5ycpA-6ehsL:
undetectable		 5ycpA-6ehsL:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 5 SER A  68
LEU A  61
ILE A  45
LEU A 431
LEU A 427
 None
 1.32A 5ycpA-6f34A:
undetectable		 5ycpA-6f34A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 5 HIS W 185
TYR W 245
LEU W 242
ILE W 233
LEU W 278
 None
 1.24A 5ycpA-6ftxW:
undetectable		 5ycpA-6ftxW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		3 GLY A 183
VAL A 356
MET A 346
 None
 0.47A 5ycpA-1b65A:
0.0		 5ycpA-1b65A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		3 GLY A 166
VAL A 139
MET A 135
 None
 0.58A 5ycpA-1c3lA:
0.0		 5ycpA-1c3lA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clw TAILSPIKE PROTEIN

(Salmonella
virus P22) 		PF09251
(PhageP22-tail) 		3 GLY A 397
VAL A 450
MET A 448
 None
 0.63A 5ycpA-1clwA:
undetectable		 5ycpA-1clwA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1col COLICIN A

(Escherichia
coli) 		PF01024
(Colicin) 		3 GLY A 184
VAL A 137
MET A 134
 None
 0.62A 5ycpA-1colA:
0.0		 5ycpA-1colA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dms DMSO REDUCTASE

(Rhodobacter
capsulatus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 GLY A 206
VAL A 217
MET A 181
 None
 0.46A 5ycpA-1dmsA:
undetectable		 5ycpA-1dmsA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		3 GLY A 220
VAL A 175
MET A 244
 None
 0.59A 5ycpA-1hcuA:
0.0		 5ycpA-1hcuA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlv GLUTATHIONE
TRANSFERASE GST1-3

(Anopheles
cracens) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 GLY A 170
VAL A 134
MET A 130
 None
 0.64A 5ycpA-1jlvA:
undetectable		 5ycpA-1jlvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		3 GLY A 217
VAL A 153
MET A 155
 None
 0.63A 5ycpA-1mppA:
undetectable		 5ycpA-1mppA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		3 GLY A 283
VAL A  44
MET A  46
 MA4  A 300 ( 3.9A)
None
None
 0.65A 5ycpA-1n9bA:
0.0		 5ycpA-1n9bA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		3 GLY A 108
VAL A 123
MET A 125
 None
 0.58A 5ycpA-1pz3A:
0.0		 5ycpA-1pz3A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		3 GLY A 481
VAL A 345
MET A 357
 None
 0.63A 5ycpA-1qafA:
undetectable		 5ycpA-1qafA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 GLY A 579
VAL A 543
MET A 593
 A  B  38 ( 4.1A)
None
None
 0.65A 5ycpA-1qf6A:
0.5		 5ycpA-1qf6A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r30 BIOTIN SYNTHASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		3 GLY A  99
VAL A 120
MET A 116
 None
 0.64A 5ycpA-1r30A:
undetectable		 5ycpA-1r30A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		3 GLY A 494
VAL A 447
MET A 444
 None
 0.57A 5ycpA-1rh1A:
undetectable		 5ycpA-1rh1A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugs NITRILE HYDRATASE
ALPHA SUBUNIT

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		3 GLY A  51
VAL A 169
MET A 195
 None
 0.54A 5ycpA-1ugsA:
undetectable		 5ycpA-1ugsA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 GLY A 128
VAL A 119
MET A 121
 None
 0.63A 5ycpA-1uiyA:
undetectable		 5ycpA-1uiyA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xjc MOBB PROTEIN HOMOLOG

(Geobacillus
stearothermophilus) 		PF03205
(MobB) 		3 GLY A  29
VAL A 162
MET A 159
 None
 0.65A 5ycpA-1xjcA:
undetectable		 5ycpA-1xjcA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLY A 281
VAL A 210
MET A 275
 None
 0.48A 5ycpA-2ag1A:
undetectable		 5ycpA-2ag1A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ee7 SPERM FLAGELLAR
PROTEIN 1

(Homo sapiens) 		PF06294
(CH_2) 		3 GLY A  43
VAL A  58
MET A  60
 None
 0.61A 5ycpA-2ee7A:
undetectable		 5ycpA-2ee7A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej5 ENOYL-COA HYDRATASE
SUBUNIT II

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		3 GLY A 111
VAL A  37
MET A  33
 None
 0.55A 5ycpA-2ej5A:
undetectable		 5ycpA-2ej5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		3 GLY A  50
VAL A 355
MET A 168
 DBO  A1001 (-3.7A)
None
None
 0.65A 5ycpA-2ewyA:
undetectable		 5ycpA-2ewyA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		3 GLY A 243
VAL A 355
MET A 168
 DBO  A1001 (-4.2A)
None
None
 0.59A 5ycpA-2ewyA:
undetectable		 5ycpA-2ewyA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7v AECTYLCITRULLINE
DEACETYLASE

(Xanthomonas
campestris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLY A 264
VAL A 171
MET A 173
 None
 0.64A 5ycpA-2f7vA:
undetectable		 5ycpA-2f7vA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i99 MU-CRYSTALLIN
HOMOLOG

(Homo sapiens) 		PF02423
(OCD_Mu_crystall) 		3 GLY A 273
VAL A 297
MET A 295
 None
 0.56A 5ycpA-2i99A:
undetectable		 5ycpA-2i99A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igw PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Caenorhabditis
elegans) 		PF00160
(Pro_isomerase) 		3 GLY A  34
VAL A 134
MET A 107
 None
 0.57A 5ycpA-2igwA:
undetectable		 5ycpA-2igwA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 GLY A 168
VAL A 602
MET A 631
 None
 0.61A 5ycpA-2ivfA:
undetectable		 5ycpA-2ivfA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwo MULTIPLE PDZ DOMAIN
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		3 GLY A1846
VAL A1835
MET A1914
 None
 0.65A 5ycpA-2iwoA:
undetectable		 5ycpA-2iwoA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2miz M04 IMMUNOEVASIN

(Murid
betaherpesvirus
1) 		PF12216
(m04gp34like) 		3 GLY A  25
VAL A 169
MET A 166
 None
 0.55A 5ycpA-2mizA:
undetectable		 5ycpA-2mizA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oua SERINE PROTEASE

(Nocardiopsis
alba) 		PF00089
(Trypsin) 		3 GLY A  56
VAL A  64
MET A  37
 None
 0.65A 5ycpA-2ouaA:
undetectable		 5ycpA-2ouaA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozz HYPOTHETICAL PROTEIN
YHFZ

(Shigella
flexneri) 		PF14503
(YhfZ_C) 		3 GLY A  29
VAL A  67
MET A  19
 None
 0.63A 5ycpA-2ozzA:
undetectable		 5ycpA-2ozzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4

(Homo sapiens) 		PF01454
(MAGE) 		3 GLY A 153
VAL A 140
MET A 136
 None
 0.59A 5ycpA-2wa0A:
undetectable		 5ycpA-2wa0A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE-1 RESTRICTION
ENZYME ECOKI
SPECIFICITY PROTEIN

(Escherichia
coli) 		PF01420
(Methylase_S) 		3 GLY A 295
VAL A 351
MET A 347
 None
 0.64A 5ycpA-2y7cA:
undetectable		 5ycpA-2y7cA:
11.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 GLY A 284
VAL A 339
MET A 348
 MC5  A   1 ( 4.5A)
MC5  A   1 (-4.6A)
MC5  A   1 ( 4.0A)
 0.21A 5ycpA-3b0qA:
41.9		 5ycpA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli) 		PF01343
(Peptidase_S49) 		3 GLY A 430
VAL A 372
MET A 403
 None
 0.64A 5ycpA-3bf0A:
undetectable		 5ycpA-3bf0A:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		3 GLY A 189
VAL A 278
MET A 274
 None
None
UDP  A 332 ( 4.3A)
 0.52A 5ycpA-3cknA:
undetectable		 5ycpA-3cknA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		3 GLY A  65
VAL A  42
MET A  37
 None
 0.55A 5ycpA-3cwrA:
undetectable		 5ycpA-3cwrA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		3 GLY A 295
VAL A 193
MET A 184
 None
None
FAD  A 602 (-4.2A)
 0.62A 5ycpA-3djlA:
undetectable		 5ycpA-3djlA:
10.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		3 GLY D 284
VAL D 339
MET D 348
 PLB  D 701 (-3.3A)
None
PLB  D 701 ( 4.7A)
 0.23A 5ycpA-3dzuD:
38.1		 5ycpA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 GLY A 678
VAL A 703
MET A 666
 None
 0.60A 5ycpA-3eqnA:
undetectable		 5ycpA-3eqnA:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3few COLICIN S4

(Escherichia
coli) 		PF01024
(Colicin) 		3 GLY X 479
VAL X 432
MET X 429
 None
 0.56A 5ycpA-3fewX:
undetectable		 5ycpA-3fewX:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gek PUTATIVE
THIOESTERASE YHDA

(Lactococcus
lactis) 		PF03061
(4HBT) 		3 GLY A  50
VAL A  93
MET A  34
 None
 0.65A 5ycpA-3gekA:
undetectable		 5ycpA-3gekA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR

(Chromobacterium
violaceum) 		PF13377
(Peripla_BP_3) 		3 GLY A  91
VAL A 166
MET A 155
 None
 0.41A 5ycpA-3h5oA:
undetectable		 5ycpA-3h5oA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic5 PUTATIVE
SACCHAROPINE
DEHYDROGENASE

(Ruegeria
pomeroyi) 		PF03435
(Sacchrp_dh_NADP) 		3 GLY A  11
VAL A  47
MET A  45
 None
 0.52A 5ycpA-3ic5A:
undetectable		 5ycpA-3ic5A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ied HEAT SHOCK PROTEIN

(Plasmodium
falciparum) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		3 GLY A 223
VAL A 108
MET A 112
 None
 0.54A 5ycpA-3iedA:
undetectable		 5ycpA-3iedA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iup PUTATIVE
NADPH:QUINONE
OXIDOREDUCTASE

(Cupriavidus
pinatubonensis) 		no annotation 3 GLY A 249
VAL A 282
MET A 305
 None
 0.58A 5ycpA-3iupA:
undetectable		 5ycpA-3iupA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwk AMINOALDEHYDE
DEHYDROGENASE

(Pisum sativum) 		PF00171
(Aldedh) 		3 GLY A 285
VAL A 269
MET A 426
 None
 0.63A 5ycpA-3iwkA:
undetectable		 5ycpA-3iwkA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9f POLIOVIRUS RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		3 GLY 7 119
VAL 7  45
MET 7 110
 NAG  7 404 (-3.6A)
None
None
 0.60A 5ycpA-3j9f7:
undetectable		 5ycpA-3j9f7:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 GLY A 239
VAL A 227
MET A 223
 None
 0.63A 5ycpA-3k96A:
undetectable		 5ycpA-3k96A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9x GLUTATHIONE-REGULATE
D POTASSIUM-EFFLUX
SYSTEM PROTEIN KEFC,
LINKER, ANCILLARY
PROTEIN KEFF

(Escherichia
coli) 		PF02254
(TrkA_N)
PF02525
(Flavodoxin_2) 		3 GLY A 411
VAL A 402
MET A 425
 None
 0.62A 5ycpA-3l9xA:
undetectable		 5ycpA-3l9xA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		3 GLY A 172
VAL A 354
MET A 346
 None
 0.52A 5ycpA-3nfbA:
undetectable		 5ycpA-3nfbA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3p MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Rubrobacter
xylanophilus) 		PF00535
(Glycos_transf_2) 		3 GLY A 182
VAL A 271
MET A 267
 None
None
GDD  A 340 (-3.4A)
 0.60A 5ycpA-3o3pA:
undetectable		 5ycpA-3o3pA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohg UNCHARACTERIZED
PROTEIN FROM DUF2233
FAMILY

(Bacteroides
ovatus) 		PF09992
(NAGPA) 		3 GLY A 223
VAL A 129
MET A 309
 None
 0.48A 5ycpA-3ohgA:
undetectable		 5ycpA-3ohgA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rst SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		3 GLY A 168
VAL A 109
MET A 141
 None
 0.63A 5ycpA-3rstA:
undetectable		 5ycpA-3rstA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00701
(DHDPS) 		3 GLY A 222
VAL A 166
MET A 134
 None
 0.65A 5ycpA-3s5nA:
undetectable		 5ycpA-3s5nA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 3 GLY A 631
VAL A 546
MET A 548
 None
 0.60A 5ycpA-3sbqA:
undetectable		 5ycpA-3sbqA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3siu U4/U6 SMALL NUCLEAR
RIBONUCLEOPROTEIN
PRP31

(Homo sapiens) 		PF01798
(Nop) 		3 GLY B 233
VAL B 208
MET B 212
 None
 0.62A 5ycpA-3siuB:
undetectable		 5ycpA-3siuB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugs UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Campylobacter
jejuni) 		no annotation 3 GLY B  33
VAL B 173
MET B  11
 None
None
FFT  B 401 (-4.3A)
 0.47A 5ycpA-3ugsB:
undetectable		 5ycpA-3ugsB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyj LYSINE-SPECIFIC
DEMETHYLASE 8

(Homo sapiens) 		PF13621
(Cupin_8) 		3 GLY A 271
VAL A 235
MET A 253
 None
 0.65A 5ycpA-3uyjA:
undetectable		 5ycpA-3uyjA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w7b FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Thermus
thermophilus) 		PF00551
(Formyl_trans_N)
PF01842
(ACT) 		3 GLY A  15
VAL A   8
MET A  48
 None
 0.59A 5ycpA-3w7bA:
undetectable		 5ycpA-3w7bA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bva THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE

(Mus musculus) 		PF02423
(OCD_Mu_crystall) 		3 GLY A 272
VAL A 296
MET A 294
 None
 0.63A 5ycpA-4bvaA:
undetectable		 5ycpA-4bvaA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e16 PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Clostridioides
difficile) 		PF00590
(TP_methylase) 		3 GLY A 180
VAL A 226
MET A 161
 None
 0.62A 5ycpA-4e16A:
undetectable		 5ycpA-4e16A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i97 DELTA CLASS 1
GLUTATHIONE
S-TRANSFERASE

(Scaptomyza
nigrita) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 GLY A 171
VAL A 135
MET A 131
 None
 0.65A 5ycpA-4i97A:
undetectable		 5ycpA-4i97A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A

(Pseudomonas
putida) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 GLY A 388
VAL A 364
MET A 362
 None
 0.66A 5ycpA-4j0qA:
undetectable		 5ycpA-4j0qA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgu COLH PROTEIN

(Hathewaya
histolytica) 		PF00801
(PKD) 		3 GLY A 797
VAL A 838
MET A 854
 None
 0.63A 5ycpA-4jguA:
undetectable		 5ycpA-4jguA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jif INTEGRIN
BETA-1-BINDING
PROTEIN 1
KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens;
Homo sapiens) 		PF10480
(ICAP-1_inte_bdg)
PF16705
(NUDIX_5) 		3 GLY A 118
VAL B 190
MET A 141
 None
 0.57A 5ycpA-4jifA:
undetectable		 5ycpA-4jifA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kwb SIGNAL PEPTIDE
PEPTIDASE SPPA

(Bacillus
subtilis) 		PF01343
(Peptidase_S49) 		3 GLY A 168
VAL A 109
MET A 141
 None
 0.66A 5ycpA-4kwbA:
undetectable		 5ycpA-4kwbA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 GLY A 733
VAL A 543
MET A 540
 None
 0.59A 5ycpA-4lglA:
undetectable		 5ycpA-4lglA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ob1 COBALT-CONTAINING
NITRILE HYDRATASE
SUBUNIT ALPHA

(Pseudonocardia
thermophila) 		PF02979
(NHase_alpha) 		3 GLY A  51
VAL A 169
MET A 195
 None
 0.52A 5ycpA-4ob1A:
undetectable		 5ycpA-4ob1A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otp SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Homo sapiens) 		PF01163
(RIO1) 		3 GLY A 177
VAL A 276
MET A 269
 None
 0.62A 5ycpA-4otpA:
undetectable		 5ycpA-4otpA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		3 GLY A 219
VAL A 299
MET A 301
 None
 0.59A 5ycpA-4petA:
undetectable		 5ycpA-4petA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyu UBIQUITIN-LIKE
PROTEIN 5

(Homo sapiens) 		PF00240
(ubiquitin) 		3 GLY A  58
VAL A   4
MET A  66
 None
 0.63A 5ycpA-4pyuA:
undetectable		 5ycpA-4pyuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2

(Homo sapiens) 		PF01130
(CD36) 		3 GLY A  78
VAL A 389
MET A 404
 None
 0.60A 5ycpA-4tw0A:
undetectable		 5ycpA-4tw0A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE IRON
PROTEIN 1

(Azotobacter
vinelandii) 		PF00142
(Fer4_NifH) 		3 GLY E 113
VAL E 122
MET E  34
 None
 0.52A 5ycpA-4wzbE:
undetectable		 5ycpA-4wzbE:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA
SLIT AND NTRK-LIKE
PROTEIN 2

(Mus musculus;
Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3)
PF13855
(LRR_8) 		3 GLY A 138
VAL B 236
MET B 209
 None
 0.63A 5ycpA-4y61A:
undetectable		 5ycpA-4y61A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 3 GLY A 585
VAL A 489
MET A 556
 CL  A 901 (-3.6A)
None
HEC  A 905 ( 3.8A)
 0.59A 5ycpA-5c2vA:
undetectable		 5ycpA-5c2vA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		3 GLY B 202
VAL B  47
MET B  44
 None
 0.53A 5ycpA-5c5bB:
undetectable		 5ycpA-5c5bB:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cnx AMINOPEPTIDASE YPDF

(Escherichia
coli) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 GLY A 359
VAL A 203
MET A 158
 None
 0.59A 5ycpA-5cnxA:
undetectable		 5ycpA-5cnxA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9t DEHYDROASCORBATE
REDUCTASE

(Oryza sativa) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 GLY A  18
VAL A   5
MET A  39
 None
 0.53A 5ycpA-5d9tA:
undetectable		 5ycpA-5d9tA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evo DEHYDROASCORBATE
REDUCTASE

(Cenchrus
americanus) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 GLY A  18
VAL A   5
MET A  39
 None
 0.61A 5ycpA-5evoA:
undetectable		 5ycpA-5evoA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f67 INACTIVATION-NO-AFTE
R-POTENTIAL D
PROTEIN

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 GLY A 376
VAL A 367
MET A 442
 None
 0.61A 5ycpA-5f67A:
undetectable		 5ycpA-5f67A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f75 THIOCYANATE
DEHYDROGENASE

(Thioalkalivibrio
paradoxus) 		no annotation 3 GLY A 460
VAL A 493
MET A 510
 None
 0.62A 5ycpA-5f75A:
undetectable		 5ycpA-5f75A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi0 PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1
PROTEIN,PHOSPHATIDYL
INOSITOL
3,4,5-TRISPHOSPHATE-
DEPENDENT RAC
EXCHANGER 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 GLY A 344
VAL A 371
MET A 373
 None
 0.64A 5ycpA-5fi0A:
undetectable		 5ycpA-5fi0A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fna CASPASE-1

(Homo sapiens) 		PF00619
(CARD) 		3 GLY A  23
VAL A  42
MET A  39
 None
 0.52A 5ycpA-5fnaA:
undetectable		 5ycpA-5fnaA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwe CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 GLY A  55
VAL A  87
MET A  78
 None
 0.65A 5ycpA-5gweA:
undetectable		 5ycpA-5gweA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh3 OXYA PROTEIN

(Actinoplanes
teichomyceticus) 		PF00067
(p450) 		3 GLY A 224
VAL A 209
MET A 205
 None
 0.66A 5ycpA-5hh3A:
undetectable		 5ycpA-5hh3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i70 PLASMEPSIN IV

(Plasmodium
falciparum) 		no annotation 3 GLY B 117
VAL B  11
MET B  15
 None
 0.61A 5ycpA-5i70B:
undetectable		 5ycpA-5i70B:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00535
(Glycos_transf_2) 		3 GLY A 184
VAL A 273
MET A 269
 3PG  A 401 (-3.3A)
None
3PG  A 401 (-3.5A)
 0.60A 5ycpA-5jqxA:
undetectable		 5ycpA-5jqxA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP1

(Rhinovirus C) 		PF00073
(Rhv) 		3 GLY A 205
VAL A 118
MET A 116
 None
 0.66A 5ycpA-5k0uA:
undetectable		 5ycpA-5k0uA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3d LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1A

(Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM) 		3 GLY A 823
VAL A 304
MET A 302
 None
 0.66A 5ycpA-5l3dA:
undetectable		 5ycpA-5l3dA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8d FIBER

(Murine
mastadenovirus
B) 		no annotation 3 GLY A 694
VAL A 667
MET A 660
 None
 0.59A 5ycpA-5n8dA:
undetectable		 5ycpA-5n8dA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		3 GLY J 461
VAL J 426
MET J 429
 None
 0.62A 5ycpA-5nilJ:
undetectable		 5ycpA-5nilJ:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		3 GLY A 368
VAL A  79
MET A  76
 5GP  A 600 ( 3.4A)
None
5GP  A 600 ( 2.9A)
 0.55A 5ycpA-5tc3A:
undetectable		 5ycpA-5tc3A:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsb MEMBRANE PROTEIN

(Bordetella
bronchiseptica) 		PF02535
(Zip) 		3 GLY A 136
VAL A 187
MET A 183
 None
 0.56A 5ycpA-5tsbA:
undetectable		 5ycpA-5tsbA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		3 GLY A 317
VAL A 308
MET A 306
 None
FAD  A 501 (-4.1A)
None
 0.62A 5ycpA-5ttkA:
undetectable		 5ycpA-5ttkA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubu PUTATIVE
ACETAMIDASE/FORMAMID
ASE

(Yersinia
enterocolitica) 		PF03069
(FmdA_AmdA) 		3 GLY A  63
VAL A 143
MET A 145
 None
 0.66A 5ycpA-5ubuA:
undetectable		 5ycpA-5ubuA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujd SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNI

(Staphylococcus
pseudintermedius) 		no annotation 3 GLY A 184
VAL A  47
MET A  55
 None
 0.48A 5ycpA-5ujdA:
undetectable		 5ycpA-5ujdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uow N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR1-8A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 GLY A 365
VAL A 150
MET A 154
 None
 0.51A 5ycpA-5uowA:
undetectable		 5ycpA-5uowA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7i SERINE
HYDROXYMETHYLTRANSFE
RASE, MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 GLY A 163
VAL A 240
MET A 237
 None
 0.46A 5ycpA-5v7iA:
undetectable		 5ycpA-5v7iA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Chaetomium
thermophilum) 		no annotation 3 GLY A  86
VAL A 162
MET A 160
 None
 0.63A 5ycpA-5w8mA:
undetectable		 5ycpA-5w8mA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjn CYTOCHROME P450

(Corynebacterium
glutamicum) 		PF00067
(p450) 		3 GLY A  28
VAL A  60
MET A  51
 None
 0.64A 5ycpA-5xjnA:
undetectable		 5ycpA-5xjnA:
9.89