SIMILAR PATTERNS OF AMINO ACIDS FOR 5YCN_A_8LXA501_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5i | PLASMINOGENACTIVATOR (Desmodusrotundus) |
PF00089(Trypsin) | 5 | GLY A 43LEU A 209ILE A 213LEU A 108LEU A 68 | None | 1.03A | 5ycnA-1a5iA:undetectable | 5ycnA-1a5iA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bev | BOVINE ENTEROVIRUSCOAT PROTEINS VP1 TOVP4 (Enterovirus E) |
PF00073(Rhv) | 5 | ILE 2 175LEU 2 206VAL 2 228LEU 2 168LEU 2 164 | None | 1.03A | 5ycnA-1bev2:undetectable | 5ycnA-1bev2:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8m | HUMAN RHINOVIRUS 16COAT PROTEIN (Rhinovirus A) |
PF00073(Rhv) | 6 | ILE 2 190LEU 2 221VAL 2 242ILE 2 240LEU 2 183LEU 2 179 | None | 1.14A | 5ycnA-1c8m2:undetectable | 5ycnA-1c8m2:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8u | ACYL-COATHIOESTERASE II (Escherichiacoli) |
PF13622(4HBT_3) | 5 | LEU A 56ARG A 193LEU A 245VAL A 273LEU A 5 | None | 1.02A | 5ycnA-1c8uA:0.0 | 5ycnA-1c8uA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6h | CHALCONE SYNTHASE (Medicago sativa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | LEU A 377ILE A 379GLY A 372VAL A 313ILE A 309 | None | 0.98A | 5ycnA-1d6hA:undetectable | 5ycnA-1d6hA:23.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1eh5 | PALMITOYL PROTEINTHIOESTERASE 1 (Bos taurus) |
PF02089(Palm_thioest) | 5 | LEU A 292GLY A 113VAL A 58ILE A 54LEU A 222 | None | 0.89A | 5ycnA-1eh5A:undetectable | 5ycnA-1eh5A:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ek6 | UDP-GALACTOSE4-EPIMERASE (Homo sapiens) |
PF16363(GDP_Man_Dehyd) | 5 | ILE A 113GLY A 111LEU A 127ILE A 164MET A 167 | None | 1.04A | 5ycnA-1ek6A:0.0 | 5ycnA-1ek6A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ewk | METABOTROPICGLUTAMATE RECEPTORSUBTYPE 1 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 5 | LEU A 202GLY A 158LEU A 86ILE A 160LEU A 438 | None | 0.82A | 5ycnA-1ewkA:0.0 | 5ycnA-1ewkA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gud | D-ALLOSE-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF13407(Peripla_BP_4) | 5 | LEU A 8ILE A 23GLY A 22VAL A 110ILE A 252 | None | 1.02A | 5ycnA-1gudA:0.0 | 5ycnA-1gudA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 5 | ILE A 285GLY A 253LEU A 377VAL A 384ILE A 395 | None | 1.04A | 5ycnA-1jioA:0.0 | 5ycnA-1jioA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mgt | PROTEIN(O6-METHYLGUANINE-DNA METHYLTRANSFERASE) (Thermococcuskodakarensis) |
PF01035(DNA_binding_1)PF09153(DUF1938) | 6 | LEU A 84TYR A 112LEU A 115VAL A 96MET A 130LEU A 164 | NoneSO4 A 301 (-4.4A)NoneNoneNoneNone | 1.23A | 5ycnA-1mgtA:undetectable | 5ycnA-1mgtA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mzr | 2,5-DIKETO-D-GLUCONATE REDUCTASE A (Escherichiacoli) |
PF00248(Aldo_ket_red) | 6 | LEU A 39ARG A 44ILE A 46GLY A 20ILE A 239LEU A 106 | None | 1.20A | 5ycnA-1mzrA:0.0 | 5ycnA-1mzrA:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pmi | PHOSPHOMANNOSEISOMERASE (Candidaalbicans) |
PF01238(PMI_typeI) | 5 | LEU A 317GLY A 262ILE A 257MET A 210LEU A 242 | None | 0.96A | 5ycnA-1pmiA:undetectable | 5ycnA-1pmiA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r1a | HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP2) (Rhinovirus A) |
PF00073(Rhv) | 6 | ILE 2 191LEU 2 222VAL 2 244ILE 2 242LEU 2 184LEU 2 180 | None | 1.24A | 5ycnA-1r1a2:undetectable | 5ycnA-1r1a2:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6x | ATP:SULFATEADENYLYLTRANSFERASE (Saccharomycescerevisiae) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 5 | LEU A 321ILE A 276LEU A 60VAL A 68LEU A 12 | None | 1.03A | 5ycnA-1r6xA:undetectable | 5ycnA-1r6xA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rzm | PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATEALDOLASE (Thermotogamaritima) |
PF00793(DAHP_synth_1) | 5 | LEU A 205ILE A 98GLY A 294VAL A 88ILE A 90 | None | 1.01A | 5ycnA-1rzmA:undetectable | 5ycnA-1rzmA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1szq | 2-METHYLCITRATEDEHYDRATASE (Escherichiacoli) |
PF03972(MmgE_PrpD) | 5 | ILE A 96GLY A 48TYR A 477LEU A 478LEU A 447 | None | 0.96A | 5ycnA-1szqA:undetectable | 5ycnA-1szqA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txg | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD(P)+] (Archaeoglobusfulgidus) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 7 | LEU A 128ARG A 131ILE A 100VAL A 87ILE A 91MET A 88LEU A 19 | None | 1.22A | 5ycnA-1txgA:undetectable | 5ycnA-1txgA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1txg | GLYCEROL-3-PHOSPHATEDEHYDROGENASE[NAD(P)+] (Archaeoglobusfulgidus) |
PF01210(NAD_Gly3P_dh_N)PF07479(NAD_Gly3P_dh_C) | 6 | LEU A 128ARG A 131ILE A 100VAL A 87MET A 88LEU A 19 | None | 1.18A | 5ycnA-1txgA:undetectable | 5ycnA-1txgA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xwi | SKD1 PROTEIN (Homo sapiens) |
PF00004(AAA)PF09336(Vps4_C) | 5 | LEU A 146ILE A 170GLY A 276ILE A 230LEU A 239 | None | 0.96A | 5ycnA-1xwiA:undetectable | 5ycnA-1xwiA:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ysj | PROTEIN YXEP (Bacillussubtilis) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ILE A 209GLY A 212VAL A 234ILE A 231MET A 249 | None | 1.00A | 5ycnA-1ysjA:undetectable | 5ycnA-1ysjA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yvp | 60-KDA SS-A/RORIBONUCLEOPROTEIN (Xenopus laevis) |
PF05731(TROVE) | 6 | ILE A 375LEU A 430VAL A 433ILE A 424MET A 437LEU A 527 | None | 1.46A | 5ycnA-1yvpA:undetectable | 5ycnA-1yvpA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw1 | CATROCOLLASTATIN (Crotalus atrox) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 5 | ILE A 317VAL A 232ILE A 228MET A 335LEU A 278 | None | 0.92A | 5ycnA-2dw1A:undetectable | 5ycnA-2dw1A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eg5 | XANTHOSINEMETHYLTRANSFERASE (Coffeacanephora) |
PF03492(Methyltransf_7) | 5 | LEU A 44ILE A 55TYR A 118LEU A 121LEU A 99 | None | 0.98A | 5ycnA-2eg5A:undetectable | 5ycnA-2eg5A:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gup | ROK FAMILY PROTEIN (Streptococcuspneumoniae) |
PF00480(ROK) | 5 | ILE A 234GLY A 231LEU A 216VAL A 244ILE A 241 | NoneSUC A 290 ( 4.5A)NoneNoneNone | 1.03A | 5ycnA-2gupA:undetectable | 5ycnA-2gupA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k77 | NEGATIVE REGULATOROF GENETICCOMPETENCE CLPC/MECB (Bacillussubtilis) |
PF02861(Clp_N) | 5 | LEU A 14ILE A 108GLY A 111LEU A 124LEU A 139 | None | 0.96A | 5ycnA-2k77A:undetectable | 5ycnA-2k77A:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oqh | PUTATIVE ISOMERASE (Streptomycescoelicolor) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 171LEU A 194VAL A 185ILE A 181MET A 151 | None | 0.93A | 5ycnA-2oqhA:undetectable | 5ycnA-2oqhA:22.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2p54 | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 247ILE A 272LEU A 321MET A 355LEU A 460 | None735 A 469 ( 4.2A)735 A 469 ( 4.3A)735 A 469 (-2.9A)735 A 469 (-4.3A) | 0.62A | 5ycnA-2p54A:37.6 | 5ycnA-2p54A:61.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rko | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 4 (Saccharomycescerevisiae) |
PF00004(AAA)PF09336(Vps4_C) | 5 | LEU A 145ILE A 169GLY A 274ILE A 228LEU A 237 | None | 0.79A | 5ycnA-2rkoA:undetectable | 5ycnA-2rkoA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vt8 | PROTEASOME INHIBITORPI31 SUBUNIT (Homo sapiens) |
PF11566(PI31_Prot_N) | 5 | LEU A 106ARG A 133ILE A 134GLY A 137LEU A 78 | None | 0.81A | 5ycnA-2vt8A:undetectable | 5ycnA-2vt8A:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vt8 | PROTEASOME INHIBITORPI31 SUBUNIT (Homo sapiens) |
PF11566(PI31_Prot_N) | 5 | LEU A 106ARG A 133ILE A 134GLY A 137VAL A 80 | None | 0.69A | 5ycnA-2vt8A:undetectable | 5ycnA-2vt8A:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wry | INTERLEUKIN-1BETA (Gallus gallus) |
PF00340(IL1) | 5 | GLY A 70TYR A 157LEU A 159LEU A 89LEU A 30 | None | 1.01A | 5ycnA-2wryA:undetectable | 5ycnA-2wryA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzl | ATP-DEPENDENTHELICASE NAM7 (Saccharomycescerevisiae) |
PF09416(UPF1_Zn_bind)PF13086(AAA_11)PF13087(AAA_12) | 5 | LEU A 468VAL A 457ILE A 455LEU A 634LEU A 409 | None | 1.00A | 5ycnA-2xzlA:undetectable | 5ycnA-2xzlA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yiz | DODECIN (Mycobacteriumtuberculosis) |
PF07311(Dodecin) | 5 | ILE A 22GLY A 24LEU A 36VAL A 62MET A 60 | None | 1.02A | 5ycnA-2yizA:undetectable | 5ycnA-2yizA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yne | GLYCYLPEPTIDEN-TETRADECANOYLTRANSFERASE (Plasmodiumvivax) |
PF01233(NMT)PF02799(NMT_C) | 5 | LEU A 67GLY A 128TYR A 95ILE A 138LEU A 116 | NoneNoneNHW A1000 (-4.3A)NoneNone | 1.03A | 5ycnA-2yneA:undetectable | 5ycnA-2yneA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zwi | ALPHA-/BETA-GALACTOSIDEALPHA-2,3-SIALYLTRANSFERASE (Photobacteriumphosphoreum) |
PF11477(PM0188) | 5 | LEU A 344ILE A 335GLY A 316LEU A 292ILE A 276 | NoneNoneC5P A 1 (-4.3A)NoneC5P A 1 (-4.0A) | 1.00A | 5ycnA-2zwiA:undetectable | 5ycnA-2zwiA:23.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | LEU A 255ARG A 280ILE A 281GLY A 284TYR A 327LEU A 330VAL A 339ILE A 341MET A 348MET A 364LEU A 453LEU A 469 | NoneNoneMC5 A 1 ( 4.8A)MC5 A 1 ( 4.5A)NoneMC5 A 1 (-4.4A)MC5 A 1 (-4.6A)MC5 A 1 (-4.5A)MC5 A 1 ( 4.0A)MC5 A 1 (-3.7A)MC5 A 1 (-4.2A)MC5 A 1 (-4.1A) | 0.57A | 5ycnA-3b0qA:41.8 | 5ycnA-3b0qA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b0q | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 255ILE A 281ILE A 341MET A 348LEU A 465 | NoneMC5 A 1 ( 4.8A)MC5 A 1 (-4.5A)MC5 A 1 ( 4.0A)None | 1.04A | 5ycnA-3b0qA:41.8 | 5ycnA-3b0qA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bdz | P450CIN (Citrobacterbraakii) |
PF00067(p450) | 5 | LEU A 279ARG A 354ILE A 353GLY A 349VAL A 386 | NoneNoneHEM A 450 (-3.8A)HEM A 450 (-3.6A)None | 0.99A | 5ycnA-3bdzA:undetectable | 5ycnA-3bdzA:22.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 10 | LEU D 255ARG D 280ILE D 281GLY D 284LEU D 330VAL D 339ILE D 341MET D 348MET D 364LEU D 469 | NoneNonePLB D 701 (-4.6A)PLB D 701 (-3.3A)PLB D 701 ( 4.1A)NonePLB D 701 (-3.6A)PLB D 701 ( 4.7A)PLB D 701 ( 4.8A)None | 0.56A | 5ycnA-3dzuD:38.1 | 5ycnA-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 7 | LEU D 255ARG D 280ILE D 281LEU D 330VAL D 339MET D 348LEU D 469 | NoneNonePLB D 701 (-4.6A)PLB D 701 ( 4.1A)NonePLB D 701 ( 4.7A)None | 1.46A | 5ycnA-3dzuD:38.1 | 5ycnA-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 6 | LEU D 255ILE D 281VAL D 339ILE D 341MET D 348LEU D 465 | NonePLB D 701 (-4.6A)NonePLB D 701 (-3.6A)PLB D 701 ( 4.7A)None | 1.09A | 5ycnA-3dzuD:38.1 | 5ycnA-3dzuD:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 7 | TYR D 327LEU D 330VAL D 339ILE D 341MET D 348MET D 364LEU D 469 | NonePLB D 701 ( 4.1A)NonePLB D 701 (-3.6A)PLB D 701 ( 4.7A)PLB D 701 ( 4.8A)None | 0.75A | 5ycnA-3dzuD:38.1 | 5ycnA-3dzuD:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0g | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1DNA-DIRECTED RNAPOLYMERASES I, II,AND III SUBUNITRPABC1 (Schizosaccharomycespombe;Schizosaccharomycespombe) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4)PF01191(RNA_pol_Rpb5_C)PF03871(RNA_pol_Rpb5_N) | 5 | ILE A1347GLY A1346VAL E 191ILE E 193LEU E 135 | None | 0.99A | 5ycnA-3h0gA:undetectable | 5ycnA-3h0gA:11.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5o | TRANSCRIPTIONALREGULATOR GNTR (Chromobacteriumviolaceum) |
PF13377(Peripla_BP_3) | 5 | ILE A 92GLY A 91VAL A 166ILE A 305MET A 155 | None | 0.90A | 5ycnA-3h5oA:undetectable | 5ycnA-3h5oA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijd | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF02219(MTHFR) | 5 | LEU A 2ILE A 91GLY A 151ILE A 213LEU A 134 | NoneNoneNoneNoneC2F A 314 ( 4.4A) | 0.91A | 5ycnA-3ijdA:undetectable | 5ycnA-3ijdA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3imo | INTEGRON CASSETTEPROTEIN (Vibrio cholerae) |
no annotation | 5 | ILE A 40GLY A 38VAL A 18ILE A 15LEU A 103 | None | 0.91A | 5ycnA-3imoA:undetectable | 5ycnA-3imoA:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ite | SIDN SIDEROPHORESYNTHETASE (Epichloefestucae) |
PF00501(AMP-binding) | 5 | GLY A 93LEU A 81ILE A 77MET A 124LEU A 56 | None | 0.97A | 5ycnA-3iteA:undetectable | 5ycnA-3iteA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kds | CELL DIVISIONPROTEIN FTSH (Thermotogamaritima) |
PF00004(AAA)PF01434(Peptidase_M41) | 5 | ILE E 262GLY E 227LEU E 245VAL E 257LEU E 233 | None | 1.03A | 5ycnA-3kdsE:1.5 | 5ycnA-3kdsE:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khs | PURINE NUCLEOSIDEPHOSPHORYLASE (Singaporegrouperiridovirus) |
PF01048(PNP_UDP_1) | 6 | LEU A 39ILE A 26GLY A 25LEU A 167VAL A 275ILE A 276 | None | 1.42A | 5ycnA-3khsA:undetectable | 5ycnA-3khsA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4u | TYROSINE SPECIFICPROTEIN PHOSPHATASE,PUTATIVE (Trypanosomabrucei) |
PF00102(Y_phosphatase) | 5 | LEU A 88TYR A 194LEU A 121VAL A 227ILE A 240 | None | 0.96A | 5ycnA-3m4uA:undetectable | 5ycnA-3m4uA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mgg | METHYLTRANSFERASE (Methanosarcinamazei) |
PF13847(Methyltransf_31) | 6 | LEU A 97ILE A 65GLY A 43LEU A 53VAL A 39ILE A 107 | None | 1.20A | 5ycnA-3mggA:undetectable | 5ycnA-3mggA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3miz | PUTATIVETRANSCRIPTIONALREGULATOR PROTEIN,LACI FAMILY (Rhizobium etli) |
PF13377(Peripla_BP_3) | 5 | ILE A 183GLY A 250LEU A 288LEU A 172LEU A 168 | None | 1.03A | 5ycnA-3mizA:undetectable | 5ycnA-3mizA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t7f | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME ATG7 (Saccharomycescerevisiae) |
PF16420(ATG7_N) | 5 | ARG A 206ILE A 241ILE A 189LEU A 153LEU A 226 | None | 1.02A | 5ycnA-3t7fA:undetectable | 5ycnA-3t7fA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tfw | PUTATIVEO-METHYLTRANSFERASE (Klebsiellapneumoniae) |
PF01596(Methyltransf_3) | 5 | LEU A 28ARG A 81ILE A 22LEU A 163LEU A 59 | None | 0.99A | 5ycnA-3tfwA:undetectable | 5ycnA-3tfwA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsy | FUSION PROTEIN4-COUMARATE--COALIGASE 1,RESVERATROL SYNTHASE (Arabidopsisthaliana;Vitis vinifera) |
PF00195(Chal_sti_synt_N)PF00501(AMP-binding)PF02797(Chal_sti_synt_C)PF13193(AMP-binding_C) | 6 | LEU A 964ILE A 966GLY A 959LEU A 911ILE A 896LEU A 971 | None | 1.36A | 5ycnA-3tsyA:undetectable | 5ycnA-3tsyA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tsy | FUSION PROTEIN4-COUMARATE--COALIGASE 1,RESVERATROL SYNTHASE (Arabidopsisthaliana;Vitis vinifera) |
PF00195(Chal_sti_synt_N)PF00501(AMP-binding)PF02797(Chal_sti_synt_C)PF13193(AMP-binding_C) | 6 | LEU A 964ILE A 966GLY A 959LEU A 911VAL A 900ILE A 896 | None | 1.39A | 5ycnA-3tsyA:undetectable | 5ycnA-3tsyA:14.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vmn | DEXTRANASE (Streptococcusmutans) |
PF13199(Glyco_hydro_66) | 5 | LEU A 672ILE A 732LEU A 638VAL A 668LEU A 590 | None | 1.01A | 5ycnA-3vmnA:undetectable | 5ycnA-3vmnA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3voh | CELLOBIOHYDROLASE (Coprinopsiscinerea) |
PF01341(Glyco_hydro_6) | 5 | ILE A 285GLY A 287LEU A 212VAL A 235ILE A 207 | None | 1.00A | 5ycnA-3vohA:undetectable | 5ycnA-3vohA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wd7 | TYPE III POLYKETIDESYNTHASES ACRIDONESYNTHASE (Citrus xmicrocarpa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | LEU A 247GLY A 372LEU A 324ILE A 309LEU A 384 | LEU A 247 ( 0.6A)GLY A 372 ( 0.0A)LEU A 324 ( 0.5A)ILE A 309 ( 0.7A)LEU A 384 ( 0.6A) | 1.03A | 5ycnA-3wd7A:undetectable | 5ycnA-3wd7A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wjs | NADH OXIDASE (Gluconobacteroxydans) |
PF00724(Oxidored_FMN) | 5 | LEU A 205ILE A 171GLY A 222ILE A 213LEU A 51 | None | 1.04A | 5ycnA-3wjsA:undetectable | 5ycnA-3wjsA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwz | D-LACTATEDEHYDROGENASE(FERMENTATIVE) (Pseudomonasaeruginosa) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 142ILE A 113GLY A 111ILE A 162MET A 163 | None | 1.01A | 5ycnA-3wwzA:undetectable | 5ycnA-3wwzA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | LEU A 166GLY A 69LEU A 283VAL A 248LEU A 293 | None | 1.03A | 5ycnA-4a9aA:undetectable | 5ycnA-4a9aA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bhy | ALANINE RACEMASE (Aeromonashydrophila) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 6 | LEU A 348GLY A 41VAL A 233ILE A 8MET A 234LEU A 66 | None | 1.40A | 5ycnA-4bhyA:undetectable | 5ycnA-4bhyA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4blu | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J (Escherichiacoli) |
PF04378(RsmJ) | 5 | LEU A 257ILE A 222GLY A 239LEU A 162LEU A 211 | None | 0.96A | 5ycnA-4bluA:undetectable | 5ycnA-4bluA:21.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d82 | AAA ATPASE, CENTRALDOMAIN PROTEIN (Metallosphaerasedula) |
PF00004(AAA)PF09336(Vps4_C) | 6 | LEU A 112ILE A 134GLY A 245ILE A 198LEU A 226LEU A 207 | None | 1.27A | 5ycnA-4d82A:undetectable | 5ycnA-4d82A:25.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmt | CHPT PROTEIN (Caulobactervibrioides) |
PF10090(HPTransfase) | 5 | LEU A 170ILE A 135LEU A 200ILE A 208LEU A 97 | None | 1.00A | 5ycnA-4fmtA:undetectable | 5ycnA-4fmtA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4grc | PUTATIVE MEMBRANEPROTEIN (Streptomycescoelicolor) |
PF04261(Dyp_perox) | 5 | LEU A 162GLY A 143MET A 267LEU A 94LEU A 201 | None | 1.03A | 5ycnA-4grcA:undetectable | 5ycnA-4grcA:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ha4 | BETA-GALACTOSIDASE (Acidilobussaccharovorans) |
PF00232(Glyco_hydro_1) | 5 | ILE A 418GLY A 419ILE A 147MET A 202LEU A 366 | PG6 A 510 ( 4.9A)NoneNonePG6 A 510 (-3.4A)None | 1.00A | 5ycnA-4ha4A:undetectable | 5ycnA-4ha4A:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k3f | PROBABLETONB-DEPENDENTRECEPTOR (Pseudomonasaeruginosa) |
PF03180(Lipoprotein_9) | 5 | ILE A 126LEU A 115VAL A 145ILE A 168LEU A 200 | None | 1.04A | 5ycnA-4k3fA:undetectable | 5ycnA-4k3fA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcb | CELL DIVISIONPROTEIN CDVC, VPS4 (Acidianushospitalis) |
PF00004(AAA)PF09336(Vps4_C) | 5 | LEU A 109ILE A 131GLY A 242ILE A 195LEU A 204 | None | 0.90A | 5ycnA-4lcbA:undetectable | 5ycnA-4lcbA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcb | CELL DIVISIONPROTEIN CDVC, VPS4 (Acidianushospitalis) |
PF00004(AAA)PF09336(Vps4_C) | 5 | LEU A 109ILE A 131GLY A 242LEU A 223LEU A 204 | None | 0.98A | 5ycnA-4lcbA:undetectable | 5ycnA-4lcbA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgm | VPS4 AAA ATPASE (Sulfolobussolfataricus) |
PF00004(AAA)PF09336(Vps4_C) | 6 | LEU A 115ILE A 137GLY A 248ILE A 201LEU A 229LEU A 210 | None | 1.28A | 5ycnA-4lgmA:undetectable | 5ycnA-4lgmA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lom | IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (Mycobacteriumtuberculosis) |
PF00475(IGPD) | 6 | GLY A 84TYR A 183LEU A 49VAL A 62ILE A 26LEU A 165 | None | 1.33A | 5ycnA-4lomA:undetectable | 5ycnA-4lomA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m6w | FANCONI ANEMIA GROUPM PROTEIN (Homo sapiens) |
PF02732(ERCC4) | 5 | GLY A1823LEU A1945VAL A1833ILE A1834LEU A1887 | SO4 A2101 (-3.5A)NoneNoneNoneNone | 0.94A | 5ycnA-4m6wA:undetectable | 5ycnA-4m6wA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otk | MYCOBACTERIAL ENZYMERV2971 (Mycobacteriumtuberculosis) |
PF00248(Aldo_ket_red) | 6 | LEU A 44ARG A 49ILE A 51GLY A 25ILE A 244LEU A 113 | None | 1.33A | 5ycnA-4otkA:undetectable | 5ycnA-4otkA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3o | MGS-MT1 (unidentified) |
PF07859(Abhydrolase_3) | 5 | ILE A 124GLY A 197TYR A 336LEU A 339ILE A 218 | None | 0.80A | 5ycnA-4q3oA:undetectable | 5ycnA-4q3oA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tyh | MITOGEN-ACTIVATEDPROTEIN KINASE 14 (Mus musculus) |
PF00069(Pkinase) | 5 | LEU B 138ILE B 206GLY B 210ILE B 131LEU B 238 | None | 0.90A | 5ycnA-4tyhB:undetectable | 5ycnA-4tyhB:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xri | PUTATIVEUNCHARACTERIZEDPROTEIN (Chaetomiumthermophilum) |
PF03810(IBN_N)PF13513(HEAT_EZ) | 5 | LEU A 173ILE A 161GLY A 159LEU A 104MET A 136 | None | 0.99A | 5ycnA-4xriA:undetectable | 5ycnA-4xriA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zh7 | OUTER MEMBRANEPROTEIN-ADHESIN (Helicobacterpylori) |
no annotation | 5 | LEU A 383ILE A 378GLY A 375LEU A 263LEU A 321 | None | 0.98A | 5ycnA-4zh7A:undetectable | 5ycnA-4zh7A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zy8 | PROTEIN LST4 (Kluyveromyceslactis) |
no annotation | 5 | LEU C 132ILE C 96LEU C 13VAL C 155LEU C 47 | None | 0.94A | 5ycnA-4zy8C:undetectable | 5ycnA-4zy8C:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9a | ADHESIN BINDINGFUCOSYLATEDHISTO-BLOOD GROUPANTIGEN,ADHESIN,ADHESIN BINDINGFUCOSYLATEDHISTO-BLOOD GROUPANTIGEN (Helicobacterpylori) |
no annotation | 5 | LEU A 377ILE A 372GLY A 369LEU A 260LEU A 315 | None | 1.02A | 5ycnA-5f9aA:undetectable | 5ycnA-5f9aA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fo1 | RIBOFLAVINBIOSYNTHESIS PROTEINRIBF (Corynebacteriumammoniagenes) |
PF01687(Flavokinase)PF06574(FAD_syn) | 5 | LEU A 219VAL A 267ILE A 252LEU A 80LEU A 183 | None | 0.93A | 5ycnA-5fo1A:undetectable | 5ycnA-5fo1A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3h | ABHYDROLASEDOMAIN-CONTAININGPROTEIN (Exiguobacteriumantarcticum) |
PF00561(Abhydrolase_1)PF08386(Abhydrolase_4) | 5 | LEU A 262ILE A 118GLY A 94VAL A 90LEU A 205 | None | 0.99A | 5ycnA-5h3hA:undetectable | 5ycnA-5h3hA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5y | NON-LEE ENCODEDEFFECTOR PROTEINNLEB (Escherichiacoli) |
no annotation | 5 | LEU A 284ARG A 186ILE A 254ILE A 249LEU A 227 | None | 0.78A | 5ycnA-5h5yA:undetectable | 5ycnA-5h5yA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h71 | ALGQ2 (Sphingomonassp.) |
PF01547(SBP_bac_1) | 5 | LEU A 92ILE A 127GLY A 316VAL A 113ILE A 117 | None | 0.94A | 5ycnA-5h71A:undetectable | 5ycnA-5h71A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jft | CASPASE 3,APOPTOSIS-RELATEDCYSTEINE PROTEASE A (Danio rerio) |
PF00656(Peptidase_C14) | 5 | ARG A 82ILE A 87VAL A 106ILE A 51LEU A 42 | None | 0.98A | 5ycnA-5jftA:undetectable | 5ycnA-5jftA:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tsh | TYPE IV PILUSBIOGENESIS ATPASEPILB (Geobactermetallireducens) |
PF00437(T2SSE) | 5 | GLY A 340LEU A 416ILE A 349LEU A 307LEU A 300 | NoneNoneNoneNoneANP A 602 (-3.6A) | 1.01A | 5ycnA-5tshA:undetectable | 5ycnA-5tshA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4h | UDP-N-ACETYLGLUCOSAMINE1-CARBOXYVINYLTRANSFERASE (Acinetobacterbaumannii) |
PF00275(EPSP_synthase) | 5 | ARG A 17GLY A 20LEU A 29VAL A 71LEU A 371 | NoneNoneNoneNoneFMT A 507 ( 4.9A) | 0.89A | 5ycnA-5u4hA:undetectable | 5ycnA-5u4hA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u63 | THIOREDOXINREDUCTASE (Haemophilusinfluenzae) |
PF07992(Pyr_redox_2) | 5 | LEU A 239ILE A 175GLY A 153TYR A 192LEU A 191 | NoneNoneNAP A 407 ( 4.1A)NoneNone | 0.94A | 5ycnA-5u63A:undetectable | 5ycnA-5u63A:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uze | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Clostridiumperfringens) |
PF00478(IMPDH) | 5 | LEU A 44ILE A 345ILE A 361MET A 358LEU A 15 | None | 0.88A | 5ycnA-5uzeA:undetectable | 5ycnA-5uzeA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2d | DIOXYGENASE (Pseudomonasbrassicacearum) |
no annotation | 5 | LEU A 34GLY A 40ILE A 421LEU A 148LEU A 145 | None | 1.03A | 5ycnA-5v2dA:undetectable | 5ycnA-5v2dA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5va3 | POTASSIUMVOLTAGE-GATEDCHANNEL SUBFAMILY HMEMBER 2 (Homo sapiens) |
PF00027(cNMP_binding)PF00520(Ion_trans)PF13426(PAS_9) | 5 | LEU A 622ILE A 560ILE A 655MET A 651LEU A 415 | None | 1.01A | 5ycnA-5va3A:undetectable | 5ycnA-5va3A:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vc2 | SERINEHYDROXYMETHYLTRANSFERASE (Helicobacterpylori) |
PF00464(SHMT) | 6 | GLY A 378TYR A 323VAL A 339ILE A 337MET A 29MET A 316 | None | 1.45A | 5ycnA-5vc2A:undetectable | 5ycnA-5vc2A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wbg | CYTOCHROME P450 2B6 (Homo sapiens) |
no annotation | 5 | LEU A 437GLY A 299ILE A 441MET A 132LEU A 199 | HEM A 501 (-4.7A)HEM A 501 ( 3.9A)HEM A 501 ( 4.5A)HEM A 501 ( 4.7A)None | 0.94A | 5ycnA-5wbgA:undetectable | 5ycnA-5wbgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xcy | GLUCANASE (Phanerochaetechrysosporium) |
PF01341(Glyco_hydro_6) | 5 | ILE A 291GLY A 293VAL A 241ILE A 213LEU A 328 | None | 1.03A | 5ycnA-5xcyA:undetectable | 5ycnA-5xcyA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xvm | STEROL3-BETA-GLUCOSYLTRANSFERASE (Saccharomycescerevisiae) |
PF00201(UDPGT)PF03033(Glyco_transf_28) | 5 | GLY A 743TYR A1156LEU A1159ILE A 862LEU A 759 | None | 0.73A | 5ycnA-5xvmA:undetectable | 5ycnA-5xvmA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwb | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Colwelliapsychrerythraea) |
PF00275(EPSP_synthase) | 5 | LEU A 196LEU A 136VAL A 163ILE A 165LEU A 30 | None | 0.97A | 5ycnA-5xwbA:undetectable | 5ycnA-5xwbA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b74 | COAGULATION FACTORXII (Homo sapiens) |
no annotation | 6 | LEU B 155ILE B 30GLY B 197LEU B 106VAL B 66LEU B 123 | None | 1.35A | 5ycnA-6b74B:undetectable | 5ycnA-6b74B:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bde | 2,4-DIHYDROXYHEPT-2-ENE-1,7-DIOIC ACIDALDOLASE (Kordia algicida) |
no annotation | 6 | LEU A 86ILE A 78LEU A 116VAL A 107ILE A 103LEU A 67 | NoneHEM A 201 (-3.6A)HEM A 201 (-4.9A)HEM A 201 (-4.3A)HEM A 201 (-4.2A)None | 1.44A | 5ycnA-6bdeA:undetectable | 5ycnA-6bdeA:undetectable |