SIMILAR PATTERNS OF AMINO ACIDS FOR 5YCN_A_8LXA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		5 GLY A  43
LEU A 209
ILE A 213
LEU A 108
LEU A  68
 None
 1.03A 5ycnA-1a5iA:
undetectable		 5ycnA-1a5iA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bev BOVINE ENTEROVIRUS
COAT PROTEINS VP1 TO
VP4

(Enterovirus E) 		PF00073
(Rhv) 		5 ILE 2 175
LEU 2 206
VAL 2 228
LEU 2 168
LEU 2 164
 None
 1.03A 5ycnA-1bev2:
undetectable		 5ycnA-1bev2:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8m HUMAN RHINOVIRUS 16
COAT PROTEIN

(Rhinovirus A) 		PF00073
(Rhv) 		6 ILE 2 190
LEU 2 221
VAL 2 242
ILE 2 240
LEU 2 183
LEU 2 179
 None
 1.14A 5ycnA-1c8m2:
undetectable		 5ycnA-1c8m2:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8u ACYL-COA
THIOESTERASE II

(Escherichia
coli) 		PF13622
(4HBT_3) 		5 LEU A  56
ARG A 193
LEU A 245
VAL A 273
LEU A   5
 None
 1.02A 5ycnA-1c8uA:
0.0		 5ycnA-1c8uA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 377
ILE A 379
GLY A 372
VAL A 313
ILE A 309
 None
 0.98A 5ycnA-1d6hA:
undetectable		 5ycnA-1d6hA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eh5 PALMITOYL PROTEIN
THIOESTERASE 1

(Bos taurus) 		PF02089
(Palm_thioest) 		5 LEU A 292
GLY A 113
VAL A  58
ILE A  54
LEU A 222
 None
 0.89A 5ycnA-1eh5A:
undetectable		 5ycnA-1eh5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek6 UDP-GALACTOSE
4-EPIMERASE

(Homo sapiens) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 113
GLY A 111
LEU A 127
ILE A 164
MET A 167
 None
 1.04A 5ycnA-1ek6A:
0.0		 5ycnA-1ek6A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 LEU A 202
GLY A 158
LEU A  86
ILE A 160
LEU A 438
 None
 0.82A 5ycnA-1ewkA:
0.0		 5ycnA-1ewkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gud D-ALLOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		5 LEU A   8
ILE A  23
GLY A  22
VAL A 110
ILE A 252
 None
 1.02A 5ycnA-1gudA:
0.0		 5ycnA-1gudA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jio CYTOCHROME P450
107A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		5 ILE A 285
GLY A 253
LEU A 377
VAL A 384
ILE A 395
 None
 1.04A 5ycnA-1jioA:
0.0		 5ycnA-1jioA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)

(Thermococcus
kodakarensis) 		PF01035
(DNA_binding_1)
PF09153
(DUF1938) 		6 LEU A  84
TYR A 112
LEU A 115
VAL A  96
MET A 130
LEU A 164
 None
SO4  A 301 (-4.4A)
None
None
None
None
 1.23A 5ycnA-1mgtA:
undetectable		 5ycnA-1mgtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		6 LEU A  39
ARG A  44
ILE A  46
GLY A  20
ILE A 239
LEU A 106
 None
 1.20A 5ycnA-1mzrA:
0.0		 5ycnA-1mzrA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		5 LEU A 317
GLY A 262
ILE A 257
MET A 210
LEU A 242
 None
 0.96A 5ycnA-1pmiA:
undetectable		 5ycnA-1pmiA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A) 		PF00073
(Rhv) 		6 ILE 2 191
LEU 2 222
VAL 2 244
ILE 2 242
LEU 2 184
LEU 2 180
 None
 1.24A 5ycnA-1r1a2:
undetectable		 5ycnA-1r1a2:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 LEU A 321
ILE A 276
LEU A  60
VAL A  68
LEU A  12
 None
 1.03A 5ycnA-1r6xA:
undetectable		 5ycnA-1r6xA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzm PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 LEU A 205
ILE A  98
GLY A 294
VAL A  88
ILE A  90
 None
 1.01A 5ycnA-1rzmA:
undetectable		 5ycnA-1rzmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szq 2-METHYLCITRATE
DEHYDRATASE

(Escherichia
coli) 		PF03972
(MmgE_PrpD) 		5 ILE A  96
GLY A  48
TYR A 477
LEU A 478
LEU A 447
 None
 0.96A 5ycnA-1szqA:
undetectable		 5ycnA-1szqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		7 LEU A 128
ARG A 131
ILE A 100
VAL A  87
ILE A  91
MET A  88
LEU A  19
 None
 1.22A 5ycnA-1txgA:
undetectable		 5ycnA-1txgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		6 LEU A 128
ARG A 131
ILE A 100
VAL A  87
MET A  88
LEU A  19
 None
 1.18A 5ycnA-1txgA:
undetectable		 5ycnA-1txgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwi SKD1 PROTEIN

(Homo sapiens) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 146
ILE A 170
GLY A 276
ILE A 230
LEU A 239
 None
 0.96A 5ycnA-1xwiA:
undetectable		 5ycnA-1xwiA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 209
GLY A 212
VAL A 234
ILE A 231
MET A 249
 None
 1.00A 5ycnA-1ysjA:
undetectable		 5ycnA-1ysjA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		6 ILE A 375
LEU A 430
VAL A 433
ILE A 424
MET A 437
LEU A 527
 None
 1.46A 5ycnA-1yvpA:
undetectable		 5ycnA-1yvpA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw1 CATROCOLLASTATIN

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 ILE A 317
VAL A 232
ILE A 228
MET A 335
LEU A 278
 None
 0.92A 5ycnA-2dw1A:
undetectable		 5ycnA-2dw1A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg5 XANTHOSINE
METHYLTRANSFERASE

(Coffea
canephora) 		PF03492
(Methyltransf_7) 		5 LEU A  44
ILE A  55
TYR A 118
LEU A 121
LEU A  99
 None
 0.98A 5ycnA-2eg5A:
undetectable		 5ycnA-2eg5A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gup ROK FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF00480
(ROK) 		5 ILE A 234
GLY A 231
LEU A 216
VAL A 244
ILE A 241
 None
SUC  A 290 ( 4.5A)
None
None
None
 1.03A 5ycnA-2gupA:
undetectable		 5ycnA-2gupA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF02861
(Clp_N) 		5 LEU A  14
ILE A 108
GLY A 111
LEU A 124
LEU A 139
 None
 0.96A 5ycnA-2k77A:
undetectable		 5ycnA-2k77A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 171
LEU A 194
VAL A 185
ILE A 181
MET A 151
 None
 0.93A 5ycnA-2oqhA:
undetectable		 5ycnA-2oqhA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 247
ILE A 272
LEU A 321
MET A 355
LEU A 460
 None
735  A 469 ( 4.2A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
 0.62A 5ycnA-2p54A:
37.6		 5ycnA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rko VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 145
ILE A 169
GLY A 274
ILE A 228
LEU A 237
 None
 0.79A 5ycnA-2rkoA:
undetectable		 5ycnA-2rkoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT

(Homo sapiens) 		PF11566
(PI31_Prot_N) 		5 LEU A 106
ARG A 133
ILE A 134
GLY A 137
LEU A  78
 None
 0.81A 5ycnA-2vt8A:
undetectable		 5ycnA-2vt8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vt8 PROTEASOME INHIBITOR
PI31 SUBUNIT

(Homo sapiens) 		PF11566
(PI31_Prot_N) 		5 LEU A 106
ARG A 133
ILE A 134
GLY A 137
VAL A  80
 None
 0.69A 5ycnA-2vt8A:
undetectable		 5ycnA-2vt8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wry INTERLEUKIN-1BETA

(Gallus gallus) 		PF00340
(IL1) 		5 GLY A  70
TYR A 157
LEU A 159
LEU A  89
LEU A  30
 None
 1.01A 5ycnA-2wryA:
undetectable		 5ycnA-2wryA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		5 LEU A 468
VAL A 457
ILE A 455
LEU A 634
LEU A 409
 None
 1.00A 5ycnA-2xzlA:
undetectable		 5ycnA-2xzlA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yiz DODECIN

(Mycobacterium
tuberculosis) 		PF07311
(Dodecin) 		5 ILE A  22
GLY A  24
LEU A  36
VAL A  62
MET A  60
 None
 1.02A 5ycnA-2yizA:
undetectable		 5ycnA-2yizA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yne GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE

(Plasmodium
vivax) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 LEU A  67
GLY A 128
TYR A  95
ILE A 138
LEU A 116
 None
None
NHW  A1000 (-4.3A)
None
None
 1.03A 5ycnA-2yneA:
undetectable		 5ycnA-2yneA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE

(Photobacterium
phosphoreum) 		PF11477
(PM0188) 		5 LEU A 344
ILE A 335
GLY A 316
LEU A 292
ILE A 276
 None
None
C5P  A   1 (-4.3A)
None
C5P  A   1 (-4.0A)
 1.00A 5ycnA-2zwiA:
undetectable		 5ycnA-2zwiA:
23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 LEU A 255
ARG A 280
ILE A 281
GLY A 284
TYR A 327
LEU A 330
VAL A 339
ILE A 341
MET A 348
MET A 364
LEU A 453
LEU A 469
 None
None
MC5  A   1 ( 4.8A)
MC5  A   1 ( 4.5A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.6A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
 0.57A 5ycnA-3b0qA:
41.8		 5ycnA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
ILE A 281
ILE A 341
MET A 348
LEU A 465
 None
MC5  A   1 ( 4.8A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
None
 1.04A 5ycnA-3b0qA:
41.8		 5ycnA-3b0qA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		5 LEU A 279
ARG A 354
ILE A 353
GLY A 349
VAL A 386
 None
None
HEM  A 450 (-3.8A)
HEM  A 450 (-3.6A)
None
 0.99A 5ycnA-3bdzA:
undetectable		 5ycnA-3bdzA:
22.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		10 LEU D 255
ARG D 280
ILE D 281
GLY D 284
LEU D 330
VAL D 339
ILE D 341
MET D 348
MET D 364
LEU D 469
 None
None
PLB  D 701 (-4.6A)
PLB  D 701 (-3.3A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
 0.56A 5ycnA-3dzuD:
38.1		 5ycnA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 LEU D 255
ARG D 280
ILE D 281
LEU D 330
VAL D 339
MET D 348
LEU D 469
 None
None
PLB  D 701 (-4.6A)
PLB  D 701 ( 4.1A)
None
PLB  D 701 ( 4.7A)
None
 1.46A 5ycnA-3dzuD:
38.1		 5ycnA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 LEU D 255
ILE D 281
VAL D 339
ILE D 341
MET D 348
LEU D 465
 None
PLB  D 701 (-4.6A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
 1.09A 5ycnA-3dzuD:
38.1		 5ycnA-3dzuD:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 TYR D 327
LEU D 330
VAL D 339
ILE D 341
MET D 348
MET D 364
LEU D 469
 None
PLB  D 701 ( 4.1A)
None
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
 0.75A 5ycnA-3dzuD:
38.1		 5ycnA-3dzuD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01191
(RNA_pol_Rpb5_C)
PF03871
(RNA_pol_Rpb5_N) 		5 ILE A1347
GLY A1346
VAL E 191
ILE E 193
LEU E 135
 None
 0.99A 5ycnA-3h0gA:
undetectable		 5ycnA-3h0gA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR

(Chromobacterium
violaceum) 		PF13377
(Peripla_BP_3) 		5 ILE A  92
GLY A  91
VAL A 166
ILE A 305
MET A 155
 None
 0.90A 5ycnA-3h5oA:
undetectable		 5ycnA-3h5oA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		5 LEU A   2
ILE A  91
GLY A 151
ILE A 213
LEU A 134
 None
None
None
None
C2F  A 314 ( 4.4A)
 0.91A 5ycnA-3ijdA:
undetectable		 5ycnA-3ijdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imo INTEGRON CASSETTE
PROTEIN

(Vibrio cholerae) 		no annotation 5 ILE A  40
GLY A  38
VAL A  18
ILE A  15
LEU A 103
 None
 0.91A 5ycnA-3imoA:
undetectable		 5ycnA-3imoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE

(Epichloe
festucae) 		PF00501
(AMP-binding) 		5 GLY A  93
LEU A  81
ILE A  77
MET A 124
LEU A  56
 None
 0.97A 5ycnA-3iteA:
undetectable		 5ycnA-3iteA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kds CELL DIVISION
PROTEIN FTSH

(Thermotoga
maritima) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 ILE E 262
GLY E 227
LEU E 245
VAL E 257
LEU E 233
 None
 1.03A 5ycnA-3kdsE:
1.5		 5ycnA-3kdsE:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		6 LEU A  39
ILE A  26
GLY A  25
LEU A 167
VAL A 275
ILE A 276
 None
 1.42A 5ycnA-3khsA:
undetectable		 5ycnA-3khsA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4u TYROSINE SPECIFIC
PROTEIN PHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00102
(Y_phosphatase) 		5 LEU A  88
TYR A 194
LEU A 121
VAL A 227
ILE A 240
 None
 0.96A 5ycnA-3m4uA:
undetectable		 5ycnA-3m4uA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgg METHYLTRANSFERASE

(Methanosarcina
mazei) 		PF13847
(Methyltransf_31) 		6 LEU A  97
ILE A  65
GLY A  43
LEU A  53
VAL A  39
ILE A 107
 None
 1.20A 5ycnA-3mggA:
undetectable		 5ycnA-3mggA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		5 ILE A 183
GLY A 250
LEU A 288
LEU A 172
LEU A 168
 None
 1.03A 5ycnA-3mizA:
undetectable		 5ycnA-3mizA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF16420
(ATG7_N) 		5 ARG A 206
ILE A 241
ILE A 189
LEU A 153
LEU A 226
 None
 1.02A 5ycnA-3t7fA:
undetectable		 5ycnA-3t7fA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		5 LEU A  28
ARG A  81
ILE A  22
LEU A 163
LEU A  59
 None
 0.99A 5ycnA-3tfwA:
undetectable		 5ycnA-3tfwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		6 LEU A 964
ILE A 966
GLY A 959
LEU A 911
ILE A 896
LEU A 971
 None
 1.36A 5ycnA-3tsyA:
undetectable		 5ycnA-3tsyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		6 LEU A 964
ILE A 966
GLY A 959
LEU A 911
VAL A 900
ILE A 896
 None
 1.39A 5ycnA-3tsyA:
undetectable		 5ycnA-3tsyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		5 LEU A 672
ILE A 732
LEU A 638
VAL A 668
LEU A 590
 None
 1.01A 5ycnA-3vmnA:
undetectable		 5ycnA-3vmnA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voh CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		5 ILE A 285
GLY A 287
LEU A 212
VAL A 235
ILE A 207
 None
 1.00A 5ycnA-3vohA:
undetectable		 5ycnA-3vohA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 247
GLY A 372
LEU A 324
ILE A 309
LEU A 384
 LEU  A 247 ( 0.6A)
GLY  A 372 ( 0.0A)
LEU  A 324 ( 0.5A)
ILE  A 309 ( 0.7A)
LEU  A 384 ( 0.6A)
 1.03A 5ycnA-3wd7A:
undetectable		 5ycnA-3wd7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		5 LEU A 205
ILE A 171
GLY A 222
ILE A 213
LEU A  51
 None
 1.04A 5ycnA-3wjsA:
undetectable		 5ycnA-3wjsA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwz D-LACTATE
DEHYDROGENASE
(FERMENTATIVE)

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 142
ILE A 113
GLY A 111
ILE A 162
MET A 163
 None
 1.01A 5ycnA-3wwzA:
undetectable		 5ycnA-3wwzA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 LEU A 166
GLY A  69
LEU A 283
VAL A 248
LEU A 293
 None
 1.03A 5ycnA-4a9aA:
undetectable		 5ycnA-4a9aA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhy ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		6 LEU A 348
GLY A  41
VAL A 233
ILE A   8
MET A 234
LEU A  66
 None
 1.40A 5ycnA-4bhyA:
undetectable		 5ycnA-4bhyA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4blu RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J

(Escherichia
coli) 		PF04378
(RsmJ) 		5 LEU A 257
ILE A 222
GLY A 239
LEU A 162
LEU A 211
 None
 0.96A 5ycnA-4bluA:
undetectable		 5ycnA-4bluA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d82 AAA ATPASE, CENTRAL
DOMAIN PROTEIN

(Metallosphaera
sedula) 		PF00004
(AAA)
PF09336
(Vps4_C) 		6 LEU A 112
ILE A 134
GLY A 245
ILE A 198
LEU A 226
LEU A 207
 None
 1.27A 5ycnA-4d82A:
undetectable		 5ycnA-4d82A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmt CHPT PROTEIN

(Caulobacter
vibrioides) 		PF10090
(HPTransfase) 		5 LEU A 170
ILE A 135
LEU A 200
ILE A 208
LEU A  97
 None
 1.00A 5ycnA-4fmtA:
undetectable		 5ycnA-4fmtA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grc PUTATIVE MEMBRANE
PROTEIN

(Streptomyces
coelicolor) 		PF04261
(Dyp_perox) 		5 LEU A 162
GLY A 143
MET A 267
LEU A  94
LEU A 201
 None
 1.03A 5ycnA-4grcA:
undetectable		 5ycnA-4grcA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ILE A 418
GLY A 419
ILE A 147
MET A 202
LEU A 366
 PG6  A 510 ( 4.9A)
None
None
PG6  A 510 (-3.4A)
None
 1.00A 5ycnA-4ha4A:
undetectable		 5ycnA-4ha4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3f PROBABLE
TONB-DEPENDENT
RECEPTOR

(Pseudomonas
aeruginosa) 		PF03180
(Lipoprotein_9) 		5 ILE A 126
LEU A 115
VAL A 145
ILE A 168
LEU A 200
 None
 1.04A 5ycnA-4k3fA:
undetectable		 5ycnA-4k3fA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 109
ILE A 131
GLY A 242
ILE A 195
LEU A 204
 None
 0.90A 5ycnA-4lcbA:
undetectable		 5ycnA-4lcbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcb CELL DIVISION
PROTEIN CDVC, VPS4

(Acidianus
hospitalis) 		PF00004
(AAA)
PF09336
(Vps4_C) 		5 LEU A 109
ILE A 131
GLY A 242
LEU A 223
LEU A 204
 None
 0.98A 5ycnA-4lcbA:
undetectable		 5ycnA-4lcbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		6 LEU A 115
ILE A 137
GLY A 248
ILE A 201
LEU A 229
LEU A 210
 None
 1.28A 5ycnA-4lgmA:
undetectable		 5ycnA-4lgmA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		6 GLY A  84
TYR A 183
LEU A  49
VAL A  62
ILE A  26
LEU A 165
 None
 1.33A 5ycnA-4lomA:
undetectable		 5ycnA-4lomA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6w FANCONI ANEMIA GROUP
M PROTEIN

(Homo sapiens) 		PF02732
(ERCC4) 		5 GLY A1823
LEU A1945
VAL A1833
ILE A1834
LEU A1887
 SO4  A2101 (-3.5A)
None
None
None
None
 0.94A 5ycnA-4m6wA:
undetectable		 5ycnA-4m6wA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		6 LEU A  44
ARG A  49
ILE A  51
GLY A  25
ILE A 244
LEU A 113
 None
 1.33A 5ycnA-4otkA:
undetectable		 5ycnA-4otkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		5 ILE A 124
GLY A 197
TYR A 336
LEU A 339
ILE A 218
 None
 0.80A 5ycnA-4q3oA:
undetectable		 5ycnA-4q3oA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU B 138
ILE B 206
GLY B 210
ILE B 131
LEU B 238
 None
 0.90A 5ycnA-4tyhB:
undetectable		 5ycnA-4tyhB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xri PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 LEU A 173
ILE A 161
GLY A 159
LEU A 104
MET A 136
 None
 0.99A 5ycnA-4xriA:
undetectable		 5ycnA-4xriA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 5 LEU A 383
ILE A 378
GLY A 375
LEU A 263
LEU A 321
 None
 0.98A 5ycnA-4zh7A:
undetectable		 5ycnA-4zh7A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zy8 PROTEIN LST4

(Kluyveromyces
lactis) 		no annotation 5 LEU C 132
ILE C  96
LEU C  13
VAL C 155
LEU C  47
 None
 0.94A 5ycnA-4zy8C:
undetectable		 5ycnA-4zy8C:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 LEU A 377
ILE A 372
GLY A 369
LEU A 260
LEU A 315
 None
 1.02A 5ycnA-5f9aA:
undetectable		 5ycnA-5f9aA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 LEU A 219
VAL A 267
ILE A 252
LEU A  80
LEU A 183
 None
 0.93A 5ycnA-5fo1A:
undetectable		 5ycnA-5fo1A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN

(Exiguobacterium
antarcticum) 		PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4) 		5 LEU A 262
ILE A 118
GLY A  94
VAL A  90
LEU A 205
 None
 0.99A 5ycnA-5h3hA:
undetectable		 5ycnA-5h3hA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5y NON-LEE ENCODED
EFFECTOR PROTEIN
NLEB

(Escherichia
coli) 		no annotation 5 LEU A 284
ARG A 186
ILE A 254
ILE A 249
LEU A 227
 None
 0.78A 5ycnA-5h5yA:
undetectable		 5ycnA-5h5yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h71 ALGQ2

(Sphingomonas
sp.) 		PF01547
(SBP_bac_1) 		5 LEU A  92
ILE A 127
GLY A 316
VAL A 113
ILE A 117
 None
 0.94A 5ycnA-5h71A:
undetectable		 5ycnA-5h71A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jft CASPASE 3,
APOPTOSIS-RELATED
CYSTEINE PROTEASE A

(Danio rerio) 		PF00656
(Peptidase_C14) 		5 ARG A  82
ILE A  87
VAL A 106
ILE A  51
LEU A  42
 None
 0.98A 5ycnA-5jftA:
undetectable		 5ycnA-5jftA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsh TYPE IV PILUS
BIOGENESIS ATPASE
PILB

(Geobacter
metallireducens) 		PF00437
(T2SSE) 		5 GLY A 340
LEU A 416
ILE A 349
LEU A 307
LEU A 300
 None
None
None
None
ANP  A 602 (-3.6A)
 1.01A 5ycnA-5tshA:
undetectable		 5ycnA-5tshA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ARG A  17
GLY A  20
LEU A  29
VAL A  71
LEU A 371
 None
None
None
None
FMT  A 507 ( 4.9A)
 0.89A 5ycnA-5u4hA:
undetectable		 5ycnA-5u4hA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		5 LEU A 239
ILE A 175
GLY A 153
TYR A 192
LEU A 191
 None
None
NAP  A 407 ( 4.1A)
None
None
 0.94A 5ycnA-5u63A:
undetectable		 5ycnA-5u63A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		5 LEU A  44
ILE A 345
ILE A 361
MET A 358
LEU A  15
 None
 0.88A 5ycnA-5uzeA:
undetectable		 5ycnA-5uzeA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 5 LEU A  34
GLY A  40
ILE A 421
LEU A 148
LEU A 145
 None
 1.03A 5ycnA-5v2dA:
undetectable		 5ycnA-5v2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va3 POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 2

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		5 LEU A 622
ILE A 560
ILE A 655
MET A 651
LEU A 415
 None
 1.01A 5ycnA-5va3A:
undetectable		 5ycnA-5va3A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		6 GLY A 378
TYR A 323
VAL A 339
ILE A 337
MET A  29
MET A 316
 None
 1.45A 5ycnA-5vc2A:
undetectable		 5ycnA-5vc2A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbg CYTOCHROME P450 2B6

(Homo sapiens) 		no annotation 5 LEU A 437
GLY A 299
ILE A 441
MET A 132
LEU A 199
 HEM  A 501 (-4.7A)
HEM  A 501 ( 3.9A)
HEM  A 501 ( 4.5A)
HEM  A 501 ( 4.7A)
None
 0.94A 5ycnA-5wbgA:
undetectable		 5ycnA-5wbgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		5 ILE A 291
GLY A 293
VAL A 241
ILE A 213
LEU A 328
 None
 1.03A 5ycnA-5xcyA:
undetectable		 5ycnA-5xcyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvm STEROL
3-BETA-GLUCOSYLTRANS
FERASE

(Saccharomyces
cerevisiae) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 GLY A 743
TYR A1156
LEU A1159
ILE A 862
LEU A 759
 None
 0.73A 5ycnA-5xvmA:
undetectable		 5ycnA-5xvmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		5 LEU A 196
LEU A 136
VAL A 163
ILE A 165
LEU A  30
 None
 0.97A 5ycnA-5xwbA:
undetectable		 5ycnA-5xwbA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 6 LEU B 155
ILE B  30
GLY B 197
LEU B 106
VAL B  66
LEU B 123
 None
 1.35A 5ycnA-6b74B:
undetectable		 5ycnA-6b74B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bde 2,4-DIHYDROXYHEPT-2-
ENE-1,7-DIOIC ACID
ALDOLASE

(Kordia algicida) 		no annotation 6 LEU A  86
ILE A  78
LEU A 116
VAL A 107
ILE A 103
LEU A  67
 None
HEM  A 201 (-3.6A)
HEM  A 201 (-4.9A)
HEM  A 201 (-4.3A)
HEM  A 201 (-4.2A)
None
 1.44A 5ycnA-6bdeA:
undetectable		 5ycnA-6bdeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 PHE A 174
SER A  75
HIS A 171
TYR A 141
 None
None
ZN  A 301 (-3.1A)
None
 1.20A 5ycnA-1jdiA:
0.0		 5ycnA-1jdiA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kd0 LRR REPEATS AND
UBIQUITIN-LIKE
DOMAIN-CONTAINING
PROTEIN AT2G30105

(Arabidopsis
thaliana) 		PF00240
(ubiquitin) 		4 CYH A  32
SER A  29
HIS A  10
HIS A   7
 None
 1.47A 5ycnA-2kd0A:
undetectable		 5ycnA-2kd0A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 CYH A1316
HIS A1350
HIS A1313
TYR A1262
 None
 1.50A 5ycnA-2nlkA:
0.0		 5ycnA-2nlkA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 326
HIS A 339
HIS A 341
TYR A 365
 None
 1.34A 5ycnA-2ox4A:
0.0		 5ycnA-2ox4A:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 CYH A 276
SER A 280
HIS A 440
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-4.0A)
735  A 469 (-4.6A)
 0.68A 5ycnA-2p54A:
37.6		 5ycnA-2p54A:
61.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 273
CYH A 276
SER A 280
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 (-4.6A)
 0.52A 5ycnA-2p54A:
37.6		 5ycnA-2p54A:
61.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 PHE A 627
CYH A 591
SER A 594
HIS A 659
 None
 1.32A 5ycnA-2qo3A:
0.0		 5ycnA-2qo3A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 PHE B  60
CYH B 115
SER B  99
HIS B 126
 None
None
None
ALY  B 125 ( 3.6A)
 1.47A 5ycnA-2x25B:
0.0		 5ycnA-2x25B:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
SER A 289
HIS A 323
HIS A 449
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.9A)
 0.39A 5ycnA-3b0qA:
41.8		 5ycnA-3b0qA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 CYH A 285
HIS A 323
HIS A 449
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-3.9A)
L41  A 501 (-4.8A)
 0.60A 5ycnA-3d5fA:
36.7		 5ycnA-3d5fA:
62.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 PHE A 282
CYH A 285
HIS A 323
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.64A 5ycnA-3d5fA:
36.7		 5ycnA-3d5fA:
62.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A1162
CYH A1163
SER A1149
HIS A1126
 None
 1.47A 5ycnA-3dlsA:
0.0		 5ycnA-3dlsA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyd CYCLIC
NUCLEOTIDE-BINDING
DOMAIN

(Methylobacillus
flagellatus) 		PF00027
(cNMP_binding) 		4 PHE A 118
CYH A  45
HIS A  -8
TYR A   2
 None
 1.25A 5ycnA-3gydA:
undetectable		 5ycnA-3gydA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7d GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 CYH A 559
SER A 557
HIS A 554
TYR A 586
 None
SO4  A  12 (-3.4A)
None
None
 1.40A 5ycnA-3k7dA:
undetectable		 5ycnA-3k7dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3koy D-ORNITHINE
AMINOMUTASE E
COMPONENT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF09043
(Lys-AminoMut_A)
PF16554
(OAM_dimer) 		4 CYH A 263
SER A 265
HIS A 158
TYR A 160
 None
Z97  A 767 ( 4.6A)
None
Z97  A 767 (-4.7A)
 1.21A 5ycnA-3koyA:
undetectable		 5ycnA-3koyA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpd NUCLEOSIDE
DIPHOSPHATE KINASE

(Encephalitozoon
cuniculi) 		PF00334
(NDK) 		4 CYH A 119
SER A 117
HIS A  48
HIS A  51
 None
 1.50A 5ycnA-3mpdA:
undetectable		 5ycnA-3mpdA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oos ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		4 CYH A 234
SER A 239
HIS A  97
TYR A 226
 PG4  A 281 (-3.5A)
None
None
None
 1.49A 5ycnA-3oosA:
undetectable		 5ycnA-3oosA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		4 PHE A 286
SER A 276
HIS A  55
HIS A  53
 None
 1.49A 5ycnA-3pl2A:
undetectable		 5ycnA-3pl2A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 PHE A  60
CYH A  58
SER A 297
HIS A 291
 None
 1.41A 5ycnA-3v5rA:
undetectable		 5ycnA-3v5rA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0y DSZC

(Rhodococcus
erythropolis) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 SER A 215
HIS A  92
HIS A 391
TYR A  96
 FMN  A 500 (-3.5A)
FMN  A 500 (-4.3A)
FMN  A 500 (-3.7A)
FMN  A 500 (-3.4A)
 1.16A 5ycnA-3x0yA:
undetectable		 5ycnA-3x0yA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hy7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Triticum
aestivum) 		PF00160
(Pro_isomerase) 		4 PHE A  67
CYH A 122
SER A 106
HIS A 133
 None
 1.49A 5ycnA-4hy7A:
undetectable		 5ycnA-4hy7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcp PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Brugia malayi) 		PF00160
(Pro_isomerase) 		4 PHE A  67
CYH A 122
SER A 106
HIS A 133
 None
 1.43A 5ycnA-4jcpA:
undetectable		 5ycnA-4jcpA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Citrus sinensis) 		PF00160
(Pro_isomerase) 		4 PHE A  67
CYH A 122
SER A 106
HIS A 133
 None
 1.46A 5ycnA-4jjmA:
undetectable		 5ycnA-4jjmA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A
TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN E

(Pseudomonas
mendocina;
Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox)
PF02332
(Phenol_Hydrox) 		4 CYH B 151
SER B 149
HIS B  33
TYR A 105
 None
 1.43A 5ycnA-4p1cB:
undetectable		 5ycnA-4p1cB:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8s RRNA N-GLYCOSIDASE

(Momordica
charantia) 		PF00161
(RIP) 		4 PHE A 107
SER A 150
HIS A 142
TYR A  76
 None
 1.11A 5ycnA-4z8sA:
undetectable		 5ycnA-4z8sA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		4 SER A1007
HIS A1421
HIS A1499
TYR A1124
 None
 1.46A 5ycnA-5hccA:
undetectable		 5ycnA-5hccA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy5 TRYPTOPHAN
6-HALOGENASE

(Streptomyces
toxytricini) 		PF04820
(Trp_halogenase) 		4 PHE A 408
SER A  54
HIS A  96
TYR A 463
 None
 1.38A 5ycnA-5hy5A:
undetectable		 5ycnA-5hy5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7k PROTEIN UNC-119
HOMOLOG A

(Homo sapiens) 		PF05351
(GMP_PDE_delta) 		4 PHE A  91
SER A 218
HIS A 165
TYR A 194
 None
 1.17A 5ycnA-5l7kA:
undetectable		 5ycnA-5l7kA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swi SUGAR HYDROLASE

(Streptococcus
pneumoniae) 		no annotation 4 PHE B 272
SER B 605
HIS B 264
TYR B 267
 None
 1.43A 5ycnA-5swiB:
undetectable		 5ycnA-5swiB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		4 PHE A  90
SER A  83
HIS A 386
HIS A 254
 SAH  A 502 (-4.5A)
None
JHZ  A 503 (-3.9A)
JHZ  A 503 (-3.8A)
 1.46A 5ycnA-5t67A:
undetectable		 5ycnA-5t67A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xde THERMOPHILIC
DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME C

(Paenibacillus
sp. A11-2) 		PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 SER A 212
HIS A  89
HIS A 388
TYR A  93
 FMN  A 501 ( 3.3A)
FMN  A 501 (-3.5A)
FMN  A 501 (-3.2A)
FMN  A 501 (-3.9A)
 1.05A 5ycnA-5xdeA:
undetectable		 5ycnA-5xdeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 4 CYH A  28
SER A  32
HIS A 105
TYR A 101
 None
 1.45A 5ycnA-6ei3A:
undetectable		 5ycnA-6ei3A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5

(Saccharomyces
cerevisiae) 		no annotation 4 SER M  84
HIS M  86
HIS M 117
TYR M 112
 None
 1.01A 5ycnA-6eu2M:
undetectable		 5ycnA-6eu2M:
undetectable