SIMILAR PATTERNS OF AMINO ACIDS FOR 5YBB_B_SAMB601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		5 THR A  23
LEU A  91
ASN A 105
PRO A 107
PHE A 146
 None
NEA  A 500 ( 4.9A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.68A 5ybbB-1g38A:
18.7		 5ybbB-1g38A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		5 THR A  30
ASP A  55
THR A  60
ASN A 119
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 ( 4.5A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.6A)
SAH  A1001 (-4.7A)
 0.77A 5ybbB-1wy7A:
13.8		 5ybbB-1wy7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		5 THR A  30
THR A  60
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 0.71A 5ybbB-1wy7A:
13.8		 5ybbB-1wy7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybm UNKNOWN PROTEIN
AT5G02240

(Arabidopsis
thaliana) 		PF13460
(NAD_binding_10) 		5 THR A  58
THR A  77
LEU A 146
PRO A 105
PHE A  99
 NAP  A 400 ( 4.5A)
NAP  A 400 (-4.5A)
None
None
None
 1.37A 5ybbB-1ybmA:
5.0		 5ybbB-1ybmA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB

(Thermococcus
kodakarensis) 		PF08423
(Rad51) 		5 THR A 115
THR A  53
PRO A  85
LEU A 108
ASN A 153
 None
 1.37A 5ybbB-2cvhA:
2.9		 5ybbB-2cvhA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		5 THR A 212
THR A 217
LEU A 148
ASN A 163
PHE A 190
 SAH  A 300 ( 4.0A)
None
None
SAH  A 300 ( 3.9A)
SAH  A 300 ( 4.6A)
 1.12A 5ybbB-2egwA:
undetectable		 5ybbB-2egwA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		6 THR A  98
ASP A 124
THR A 129
LEU A 182
PRO A 198
PHE A 226
 SAM  A 400 (-3.8A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-2.9A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
 0.66A 5ybbB-2f8lA:
25.3		 5ybbB-2f8lA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		8 THR A 154
ARG A 156
ASP A 176
THR A 181
LEU A 245
ASN A 259
PRO A 261
PHE A 288
 SAM  A 500 (-3.6A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.9A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 0.68A 5ybbB-2okcA:
35.6		 5ybbB-2okcA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy3 ENDOCHITINASE

(Saccharomyces
cerevisiae) 		PF00704
(Glyco_hydro_18) 		5 THR A 132
ARG A 142
LYS A 170
LEU A 200
PHE A 154
 None
 1.29A 5ybbB-2uy3A:
undetectable		 5ybbB-2uy3A:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		7 THR B 151
ASP B 173
THR B 178
LEU B 250
ASN B 266
PRO B 268
PHE B 292
 None
 0.75A 5ybbB-2y7cB:
30.6		 5ybbB-2y7cB:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 THR A  22
THR A 325
LEU A 272
ASN A 448
PHE A 243
 None
 1.21A 5ybbB-3decA:
undetectable		 5ybbB-3decA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 THR A  21
ASP A  54
LEU A  87
ASN A  12
PRO A 105
 None
None
None
None
NIO  A 500 (-4.7A)
 1.48A 5ybbB-3i45A:
3.3		 5ybbB-3i45A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR A 201
ASP A 227
LEU A 286
ASN A 304
PRO A 306
 None
 0.98A 5ybbB-3lkdA:
26.6		 5ybbB-3lkdA:
27.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR A 201
LEU A 286
ASN A 304
PRO A 306
PHE A 339
 None
 1.04A 5ybbB-3lkdA:
26.6		 5ybbB-3lkdA:
27.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		7 THR A 201
ASP A 223
THR A 228
LEU A 290
ASN A 309
PRO A 311
PHE A 337
 None
 0.66A 5ybbB-3ufbA:
36.3		 5ybbB-3ufbA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		6 THR A 201
ASP A 223
THR A 228
PRO A 266
ASN A 309
PRO A 311
 None
 0.81A 5ybbB-3ufbA:
36.3		 5ybbB-3ufbA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ASP A 161
PRO A 191
LEU A 224
ASN A 241
PHE A 223
 AW2  A 502 (-2.9A)
AW2  A 502 ( 4.8A)
AW2  A 502 ( 4.3A)
AW2  A 502 (-4.3A)
AW2  A 502 (-3.4A)
 1.39A 5ybbB-4er6A:
undetectable		 5ybbB-4er6A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 ARG A 488
PRO A 307
LEU A 468
ASN A 623
PHE A 598
 None
 1.41A 5ybbB-4g56A:
6.0		 5ybbB-4g56A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 ARG A 492
PRO A 311
LEU A 472
ASN A 627
PHE A 602
 None
 1.28A 5ybbB-4gqbA:
undetectable		 5ybbB-4gqbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 THR A 740
THR A 648
LEU A 568
ASN A 678
PHE A 564
 None
 1.49A 5ybbB-4gzuA:
undetectable		 5ybbB-4gzuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		5 THR A 160
PRO A 159
LEU A 165
ASN A 264
PHE A 262
 None
 1.48A 5ybbB-4m73A:
8.1		 5ybbB-4m73A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 THR A 869
ASP A 902
THR A 907
ASN A1018
PRO A1020
 None
 0.59A 5ybbB-4xqkA:
20.9		 5ybbB-4xqkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 THR A 677
THR A 936
LEU A 943
ASN A 656
PRO A 658
 None
 1.13A 5ybbB-4zhjA:
undetectable		 5ybbB-4zhjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ASP A 161
LYS A 187
PRO A 191
LEU A 224
ASN A 241
 None
None
None
None
5F7  A 401 (-3.6A)
 0.84A 5ybbB-5dtrA:
7.0		 5ybbB-5dtrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ASP A 161
PRO A 191
LEU A 224
ASN A 241
PHE A 223
 None
None
None
5F7  A 401 (-3.6A)
None
 1.41A 5ybbB-5dtrA:
7.0		 5ybbB-5dtrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		5 THR A 869
ASP A 902
THR A 907
ASN A1018
PRO A1020
 None
 0.70A 5ybbB-5ffjA:
20.7		 5ybbB-5ffjA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 5 THR C 316
ASP C 361
CYH C 366
LEU C 462
ASN C 481
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-3.2A)
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
 1.04A 5ybbB-5hr4C:
17.1		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 6 THR C 316
ASP C 361
PRO C 418
LEU C 462
ASN C 481
PRO C 483
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
None
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.62A 5ybbB-5hr4C:
17.1		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 THR A4194
PRO A4226
LEU A4231
ASN A4196
PRO A4198
 None
 1.50A 5ybbB-5iicA:
undetectable		 5ybbB-5iicA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 THR A 776
LEU A 642
ASN A 724
PRO A 742
PHE A 730
 NA  A 905 (-3.8A)
None
NA  A 905 (-3.4A)
None
None
 1.42A 5ybbB-5uj6A:
undetectable		 5ybbB-5uj6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		PF01044
(Vinculin)
no annotation 		5 ARG A 188
ASP A 141
THR B  46
LEU A  89
PHE A 133
 None
 1.32A 5ybbB-5xa5A:
undetectable		 5ybbB-5xa5A:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 5 ASP A 195
LYS A 235
ASN A 279
PRO A 281
PHE A 305
 SAM  A 601 (-3.5A)
None
SAM  A 601 (-3.7A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-4.7A)
 0.97A 5ybbB-5ybbA:
59.0		 5ybbB-5ybbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 11 THR A 173
ARG A 175
ASP A 195
THR A 200
CYH A 201
LYS A 234
PRO A 238
LEU A 262
ASN A 279
PRO A 281
PHE A 305
 SAM  A 601 (-3.2A)
SAM  A 601 ( 4.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.4A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.7A)
SAM  A 601 ( 4.8A)
SAM  A 601 ( 4.2A)
SAM  A 601 (-3.7A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-4.7A)
 0.12A 5ybbB-5ybbA:
59.0		 5ybbB-5ybbA:
100.00