SIMILAR PATTERNS OF AMINO ACIDS FOR 5YBB_B_SAMB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g38 MODIFICATION
METHYLASE TAQI

(Thermus
aquaticus) 		PF07669
(Eco57I)
PF12950
(TaqI_C) 		5 THR A  23
LEU A  91
ASN A 105
PRO A 107
PHE A 146
 None
NEA  A 500 ( 4.9A)
NEA  A 500 (-4.5A)
NEA  A 500 (-3.8A)
None
 0.68A 5ybbB-1g38A:
18.7		 5ybbB-1g38A:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		5 THR A  30
ASP A  55
THR A  60
ASN A 119
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 ( 4.5A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.6A)
SAH  A1001 (-4.7A)
 0.77A 5ybbB-1wy7A:
13.8		 5ybbB-1wy7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy7 HYPOTHETICAL PROTEIN
PH1948

(Pyrococcus
horikoshii) 		PF05175
(MTS) 		5 THR A  30
THR A  60
ASN A 119
PRO A 121
PHE A 133
 SAH  A1001 (-4.0A)
SAH  A1001 (-3.6A)
SAH  A1001 (-4.6A)
None
SAH  A1001 (-4.7A)
 0.71A 5ybbB-1wy7A:
13.8		 5ybbB-1wy7A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybm UNKNOWN PROTEIN
AT5G02240

(Arabidopsis
thaliana) 		PF13460
(NAD_binding_10) 		5 THR A  58
THR A  77
LEU A 146
PRO A 105
PHE A  99
 NAP  A 400 ( 4.5A)
NAP  A 400 (-4.5A)
None
None
None
 1.37A 5ybbB-1ybmA:
5.0		 5ybbB-1ybmA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvh DNA REPAIR AND
RECOMBINATION
PROTEIN RADB

(Thermococcus
kodakarensis) 		PF08423
(Rad51) 		5 THR A 115
THR A  53
PRO A  85
LEU A 108
ASN A 153
 None
 1.37A 5ybbB-2cvhA:
2.9		 5ybbB-2cvhA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		5 THR A 212
THR A 217
LEU A 148
ASN A 163
PHE A 190
 SAH  A 300 ( 4.0A)
None
None
SAH  A 300 ( 3.9A)
SAH  A 300 ( 4.6A)
 1.12A 5ybbB-2egwA:
undetectable		 5ybbB-2egwA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		6 THR A  98
ASP A 124
THR A 129
LEU A 182
PRO A 198
PHE A 226
 SAM  A 400 (-3.8A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-2.9A)
SAM  A 400 ( 4.8A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.9A)
 0.66A 5ybbB-2f8lA:
25.3		 5ybbB-2f8lA:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		8 THR A 154
ARG A 156
ASP A 176
THR A 181
LEU A 245
ASN A 259
PRO A 261
PHE A 288
 SAM  A 500 (-3.6A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.9A)
SAM  A 500 (-3.1A)
SAM  A 500 ( 4.8A)
SAM  A 500 (-3.9A)
SAM  A 500 (-4.1A)
SAM  A 500 (-4.8A)
 0.68A 5ybbB-2okcA:
35.6		 5ybbB-2okcA:
30.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uy3 ENDOCHITINASE

(Saccharomyces
cerevisiae) 		PF00704
(Glyco_hydro_18) 		5 THR A 132
ARG A 142
LYS A 170
LEU A 200
PHE A 154
 None
 1.29A 5ybbB-2uy3A:
undetectable		 5ybbB-2uy3A:
20.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		7 THR B 151
ASP B 173
THR B 178
LEU B 250
ASN B 266
PRO B 268
PHE B 292
 None
 0.75A 5ybbB-2y7cB:
30.6		 5ybbB-2y7cB:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 THR A  22
THR A 325
LEU A 272
ASN A 448
PHE A 243
 None
 1.21A 5ybbB-3decA:
undetectable		 5ybbB-3decA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		5 THR A  21
ASP A  54
LEU A  87
ASN A  12
PRO A 105
 None
None
None
None
NIO  A 500 (-4.7A)
 1.48A 5ybbB-3i45A:
3.3		 5ybbB-3i45A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR A 201
ASP A 227
LEU A 286
ASN A 304
PRO A 306
 None
 0.98A 5ybbB-3lkdA:
26.6		 5ybbB-3lkdA:
27.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		5 THR A 201
LEU A 286
ASN A 304
PRO A 306
PHE A 339
 None
 1.04A 5ybbB-3lkdA:
26.6		 5ybbB-3lkdA:
27.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		7 THR A 201
ASP A 223
THR A 228
LEU A 290
ASN A 309
PRO A 311
PHE A 337
 None
 0.66A 5ybbB-3ufbA:
36.3		 5ybbB-3ufbA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		6 THR A 201
ASP A 223
THR A 228
PRO A 266
ASN A 309
PRO A 311
 None
 0.81A 5ybbB-3ufbA:
36.3		 5ybbB-3ufbA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4er6 HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ASP A 161
PRO A 191
LEU A 224
ASN A 241
PHE A 223
 AW2  A 502 (-2.9A)
AW2  A 502 ( 4.8A)
AW2  A 502 ( 4.3A)
AW2  A 502 (-4.3A)
AW2  A 502 (-3.4A)
 1.39A 5ybbB-4er6A:
undetectable		 5ybbB-4er6A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 ARG A 488
PRO A 307
LEU A 468
ASN A 623
PHE A 598
 None
 1.41A 5ybbB-4g56A:
6.0		 5ybbB-4g56A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqb PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Homo sapiens) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 ARG A 492
PRO A 311
LEU A 472
ASN A 627
PHE A 602
 None
 1.28A 5ybbB-4gqbA:
undetectable		 5ybbB-4gqbA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzu FERM, RHOGEF AND
PLECKSTRIN
DOMAIN-CONTAINING
PROTEIN 2

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 THR A 740
THR A 648
LEU A 568
ASN A 678
PHE A 564
 None
 1.49A 5ybbB-4gzuA:
undetectable		 5ybbB-4gzuA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m73 METHYLTRANSFERASE
MPPJ

(Streptomyces
hygroscopicus) 		PF13649
(Methyltransf_25) 		5 THR A 160
PRO A 159
LEU A 165
ASN A 264
PHE A 262
 None
 1.48A 5ybbB-4m73A:
8.1		 5ybbB-4m73A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 THR A 869
ASP A 902
THR A 907
ASN A1018
PRO A1020
 None
 0.59A 5ybbB-4xqkA:
20.9		 5ybbB-4xqkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		5 THR A 677
THR A 936
LEU A 943
ASN A 656
PRO A 658
 None
 1.13A 5ybbB-4zhjA:
undetectable		 5ybbB-4zhjA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ASP A 161
LYS A 187
PRO A 191
LEU A 224
ASN A 241
 None
None
None
None
5F7  A 401 (-3.6A)
 0.84A 5ybbB-5dtrA:
7.0		 5ybbB-5dtrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtr HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Homo sapiens) 		PF08123
(DOT1) 		5 ASP A 161
PRO A 191
LEU A 224
ASN A 241
PHE A 223
 None
None
None
5F7  A 401 (-3.6A)
None
 1.41A 5ybbB-5dtrA:
7.0		 5ybbB-5dtrA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		5 THR A 869
ASP A 902
THR A 907
ASN A1018
PRO A1020
 None
 0.70A 5ybbB-5ffjA:
20.7		 5ybbB-5ffjA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 5 THR C 316
ASP C 361
CYH C 366
LEU C 462
ASN C 481
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-3.2A)
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
 1.04A 5ybbB-5hr4C:
17.1		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 6 THR C 316
ASP C 361
PRO C 418
LEU C 462
ASN C 481
PRO C 483
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
None
SFG  C1002 ( 4.4A)
SFG  C1002 (-3.8A)
SFG  C1002 (-4.1A)
 0.62A 5ybbB-5hr4C:
17.1		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 THR A4194
PRO A4226
LEU A4231
ASN A4196
PRO A4198
 None
 1.50A 5ybbB-5iicA:
undetectable		 5ybbB-5iicA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		5 THR A 776
LEU A 642
ASN A 724
PRO A 742
PHE A 730
 NA  A 905 (-3.8A)
None
NA  A 905 (-3.4A)
None
None
 1.42A 5ybbB-5uj6A:
undetectable		 5ybbB-5uj6A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1
BETA-CATENIN-LIKE
PROTEIN HMP-2

(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		PF01044
(Vinculin)
no annotation 		5 ARG A 188
ASP A 141
THR B  46
LEU A  89
PHE A 133
 None
 1.32A 5ybbB-5xa5A:
undetectable		 5ybbB-5xa5A:
18.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 5 ASP A 195
LYS A 235
ASN A 279
PRO A 281
PHE A 305
 SAM  A 601 (-3.5A)
None
SAM  A 601 (-3.7A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-4.7A)
 0.97A 5ybbB-5ybbA:
59.0		 5ybbB-5ybbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 11 THR A 173
ARG A 175
ASP A 195
THR A 200
CYH A 201
LYS A 234
PRO A 238
LEU A 262
ASN A 279
PRO A 281
PHE A 305
 SAM  A 601 (-3.2A)
SAM  A 601 ( 4.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-4.4A)
SAM  A 601 (-3.2A)
SAM  A 601 (-4.7A)
SAM  A 601 ( 4.8A)
SAM  A 601 ( 4.2A)
SAM  A 601 (-3.7A)
SAM  A 601 ( 4.5A)
SAM  A 601 (-4.7A)
 0.12A 5ybbB-5ybbA:
59.0		 5ybbB-5ybbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 373
GLY A 374
GLY A 376
THR A 132
 None
 0.74A 5ybbB-1d6hA:
undetectable		 5ybbB-1d6hA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 GLY A 100
GLY A 102
GLU A 121
ASN A 152
 None
 0.74A 5ybbB-1inlA:
8.1		 5ybbB-1inlA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ALA A 150
GLY A 148
GLY A 534
ASN A 312
 None
None
None
FAD  A 701 (-4.0A)
 0.78A 5ybbB-1jscA:
undetectable		 5ybbB-1jscA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldi GLYCEROL UPTAKE
FACILITATOR PROTEIN

(Escherichia
coli) 		PF00230
(MIP) 		4 PHE A 238
GLY A 239
GLY A 243
THR A 198
 None
 0.74A 5ybbB-1ldiA:
undetectable		 5ybbB-1ldiA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n94 PROTEIN
FARNESYLTRANSFERASE
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		4 ALA B 226
GLY B 224
GLY B 189
GLU B 227
 None
 0.61A 5ybbB-1n94B:
undetectable		 5ybbB-1n94B:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		4 PHE B 354
GLY B  12
ASN B  19
THR B  18
 None
 0.78A 5ybbB-1ox4B:
undetectable		 5ybbB-1ox4B:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		4 PHE A  20
ALA A  43
GLY A  19
GLY A  16
 None
None
NAD  A 360 (-3.3A)
NAD  A 360 (-3.4A)
 0.78A 5ybbB-1rkxA:
4.1		 5ybbB-1rkxA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s2x CAG-Z

(Helicobacter
pylori) 		PF09053
(CagZ) 		4 PHE A 112
ALA A 106
GLY A   4
ASN A 178
 None
 0.78A 5ybbB-1s2xA:
undetectable		 5ybbB-1s2xA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		4 PHE A  59
GLY A  60
GLY A  64
THR A  87
 None
 0.71A 5ybbB-1t9kA:
2.4		 5ybbB-1t9kA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 376
GLY A 377
GLY A 379
THR A 135
 None
 0.81A 5ybbB-1u0uA:
undetectable		 5ybbB-1u0uA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		4 PHE A 262
GLY A 232
GLY A 101
THR A 257
 None
 0.81A 5ybbB-1w9xA:
undetectable		 5ybbB-1w9xA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 373
GLY A 374
GLY A 376
THR A 132
 None
 0.81A 5ybbB-1z1eA:
undetectable		 5ybbB-1z1eA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLY A 517
GLY A 508
ASN A 693
THR A 694
 None
 0.65A 5ybbB-2c11A:
undetectable		 5ybbB-2c11A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmd LECTIN

(Leucomphalos
mildbraedii) 		PF00139
(Lectin_legB) 		4 ALA A  85
GLY A 217
GLY A  45
THR A 130
 MAN  A 241 (-3.2A)
MAN  A 241 (-3.1A)
None
None
 0.69A 5ybbB-2fmdA:
undetectable		 5ybbB-2fmdA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 GLY B 358
GLY B 328
GLU B 357
THR A 174
 None
 0.75A 5ybbB-2fpgB:
undetectable		 5ybbB-2fpgB:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 ALA A 453
GLY A 516
GLY A 519
ASN A 461
 None
 0.82A 5ybbB-2hauA:
undetectable		 5ybbB-2hauA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 PHE A 486
ALA A 489
GLY A 487
GLY A 413
 None
 0.76A 5ybbB-2i3oA:
undetectable		 5ybbB-2i3oA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n47 SLR1183 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13649
(Methyltransf_25) 		4 ALA A  37
GLY A  39
GLY A  41
ASN A  84
 None
 0.48A 5ybbB-2n47A:
7.8		 5ybbB-2n47A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 PHE A 880
GLY A 881
GLY A 873
GLU A 891
 None
SO4  A3014 (-3.4A)
None
None
 0.80A 5ybbB-2o2qA:
undetectable		 5ybbB-2o2qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		4 GLY A  90
GLY A  92
GLU A 116
ASN A 148
 SAH  A 301 (-3.4A)
None
SAH  A 301 (-2.8A)
SAH  A 301 (-3.0A)
 0.52A 5ybbB-2pbfA:
9.0		 5ybbB-2pbfA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6z UPF0341 PROTEIN IN
RSP 3' REGION

(Neisseria
gonorrhoeae) 		PF04445
(SAM_MT) 		4 GLY A  93
GLY A  95
GLU A 112
ASN A 147
 None
 0.60A 5ybbB-2r6zA:
6.2		 5ybbB-2r6zA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF02390
(Methyltransf_4) 		4 GLY E 105
GLY E 107
GLU E 126
ASN E 161
 SAM  E1287 (-3.6A)
None
SAM  E1287 (-2.6A)
SAM  E1287 (-3.4A)
 0.65A 5ybbB-2vdvE:
3.7		 5ybbB-2vdvE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vge RELA-ASSOCIATED
INHIBITOR

(Homo sapiens) 		PF00023
(Ank)
PF14604
(SH3_9) 		4 PHE A 815
ALA A 717
GLY A 816
ASN A 685
 None
 0.81A 5ybbB-2vgeA:
undetectable		 5ybbB-2vgeA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ALA A 550
GLY A 533
GLU A 206
THR A 566
 None
TRS  A1733 (-4.4A)
None
None
 0.78A 5ybbB-2xn1A:
undetectable		 5ybbB-2xn1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
SUBUNIT 4 ISOFORM 1
CYTOCHROME C OXIDASE
POLYPEPTIDE 7B

(Bos taurus;
Bos taurus) 		PF02936
(COX4)
PF05392
(COX7B) 		4 PHE K  24
ALA K  19
GLY K  21
GLY D  83
 None
 0.71A 5ybbB-2y69K:
undetectable		 5ybbB-2y69K:
8.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ALA B 175
GLY B 177
GLU B 216
THR B 249
 None
 0.52A 5ybbB-2y7cB:
30.6		 5ybbB-2y7cB:
31.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 GLY B 177
GLU B 216
ASN B 248
THR B 249
 None
 0.56A 5ybbB-2y7cB:
30.6		 5ybbB-2y7cB:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 ALA A 433
GLY A  25
GLY A  20
THR A 437
 None
None
FAD  A 600 (-3.3A)
None
 0.75A 5ybbB-2z5xA:
undetectable		 5ybbB-2z5xA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbw THIOREDOXIN
REDUCTASE

(Thermus
thermophilus) 		PF07992
(Pyr_redox_2) 		4 PHE A  22
GLY A  21
GLY A  17
THR A   6
 None
 0.70A 5ybbB-2zbwA:
undetectable		 5ybbB-2zbwA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 383
GLY A 384
GLY A 386
THR A 142
 None
GOL  A 500 ( 4.2A)
None
GOL  A 501 ( 4.7A)
 0.76A 5ybbB-3awkA:
undetectable		 5ybbB-3awkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN
POLYPROTEIN

(Senecavirus A;
Senecavirus A) 		no annotation
PF00073
(Rhv) 		4 GLY A 196
GLY A 207
GLU C 138
THR C 225
 None
 0.66A 5ybbB-3cjiA:
undetectable		 5ybbB-3cjiA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckk TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Homo sapiens) 		PF02390
(Methyltransf_4) 		4 GLY A  56
GLY A  58
GLU A  77
ASN A 110
 SAM  A 301 (-3.5A)
None
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
 0.47A 5ybbB-3ckkA:
5.9		 5ybbB-3ckkA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwz RAB6-INTERACTING
PROTEIN 1

(Mus musculus) 		PF01477
(PLAT)
PF02759
(RUN) 		4 ALA B 998
GLY B1025
GLY B1027
THR B 948
 None
 0.80A 5ybbB-3cwzB:
undetectable		 5ybbB-3cwzB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqz ALPHA-HYDROXYNITRILE
LYASE-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 PHE A 107
ALA A  88
GLY A  84
GLY A  79
 None
 0.49A 5ybbB-3dqzA:
undetectable		 5ybbB-3dqzA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dup MUTT/NUDIX FAMILY
PROTEIN

(Rhodospirillum
rubrum) 		PF15916
(DUF4743) 		4 ALA A 154
GLY A 136
GLU A 174
ASN A 166
 None
 0.81A 5ybbB-3dupA:
undetectable		 5ybbB-3dupA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv8 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

([Eubacterium]
rectale) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLY A  33
GLU A  95
ASN A 176
THR A 173
 None
 0.80A 5ybbB-3dv8A:
undetectable		 5ybbB-3dv8A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeh PUTATIVE LIGHT AND
REDOX SENSING
HISTIDINE KINASE

(Haloarcula
marismortui) 		PF08447
(PAS_3) 		4 ALA A 121
GLY A 119
GLY A 104
ASN A  21
 PG5  A 126 ( 4.6A)
None
None
None
 0.78A 5ybbB-3eehA:
undetectable		 5ybbB-3eehA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 PHE A 116
ALA A  93
GLY A  90
GLY A  88
 None
 0.80A 5ybbB-3evzA:
10.9		 5ybbB-3evzA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fi1 NA(+)/H(+)
ANTIPORTER NHAA

(Escherichia
coli) 		PF06965
(Na_H_antiport_1) 		4 PHE A 339
ALA A 131
GLY A 338
GLY A 336
 None
 0.75A 5ybbB-3fi1A:
undetectable		 5ybbB-3fi1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fku NEUTRALIZING
ANTIBODY F10

(Homo sapiens) 		no annotation 4 PHE X 240
GLY X 241
GLY X 243
ASN X 164
 None
 0.80A 5ybbB-3fkuX:
undetectable		 5ybbB-3fkuX:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2p PCZA361.24

(Amycolatopsis
orientalis) 		PF13649
(Methyltransf_25) 		4 ALA A  71
GLY A  73
GLY A  75
GLU A  92
 SAH  A 500 (-3.1A)
SAH  A 500 (-3.2A)
None
SAH  A 500 (-2.8A)
 0.68A 5ybbB-3g2pA:
9.0		 5ybbB-3g2pA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 GLY A 507
GLY A 498
ASN A 684
THR A 685
 None
None
None
TPQ  A 461 ( 2.4A)
 0.78A 5ybbB-3higA:
undetectable		 5ybbB-3higA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khk TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLATION SUBUNIT

(Methanosarcina
mazei) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ALA A 251
GLY A 253
GLY A 255
GLU A 289
 None
 0.43A 5ybbB-3khkA:
27.5		 5ybbB-3khkA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkd TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Streptococcus
thermophilus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 GLY A 231
GLY A 233
GLU A 255
THR A 285
 None
 0.69A 5ybbB-3lkdA:
26.6		 5ybbB-3lkdA:
27.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcz O-METHYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 ALA A 184
GLY A 186
GLY A 188
ASN A 234
 None
 0.72A 5ybbB-3mczA:
10.2		 5ybbB-3mczA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PHE A 860
ALA A 855
GLY A 857
THR A 781
 None
 0.81A 5ybbB-3n23A:
undetectable		 5ybbB-3n23A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 PHE A  67
GLY A  66
GLY A 179
THR A 161
 None
SAM  A 670 (-3.5A)
SAM  A 670 (-3.5A)
None
 0.79A 5ybbB-3ps9A:
7.9		 5ybbB-3ps9A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		4 ALA A  58
GLY A  60
GLY A  62
GLU A  79
 SAH  A 263 (-3.5A)
SAH  A 263 (-3.3A)
None
SAH  A 263 (-2.7A)
 0.68A 5ybbB-3px2A:
9.4		 5ybbB-3px2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		4 PHE A 960
GLY A 961
GLY A 963
THR A 719
 None
 0.70A 5ybbB-3tsyA:
undetectable		 5ybbB-3tsyA:
19.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ALA A 225
GLY A 227
GLY A 229
ASN A 288
 None
 0.67A 5ybbB-3ufbA:
36.3		 5ybbB-3ufbA:
39.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ufb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Vibrio
vulnificus) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ALA A 225
GLY A 227
GLY A 229
GLU A 261
 None
 0.69A 5ybbB-3ufbA:
36.3		 5ybbB-3ufbA:
39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 PHE A 683
ALA A 567
GLY A 553
THR A 441
 None
 0.71A 5ybbB-3v8uA:
undetectable		 5ybbB-3v8uA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 ALA A 309
GLY A 342
GLY A 290
THR A 337
 None
 0.80A 5ybbB-3wa1A:
undetectable		 5ybbB-3wa1A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		4 PHE A 218
ALA A 213
GLY A 215
GLY A 182
 None
 0.79A 5ybbB-3zouA:
undetectable		 5ybbB-3zouA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 ALA A 424
GLY A  16
GLY A  11
THR A 428
 None
None
FAD  A 600 (-3.1A)
None
 0.75A 5ybbB-3zyxA:
undetectable		 5ybbB-3zyxA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4av6 K(+)-STIMULATED
PYROPHOSPHATE-ENERGI
ZED SODIUM PUMP

(Thermotoga
maritima) 		PF03030
(H_PPase) 		4 GLY A 195
GLY A 235
ASN A 606
THR A 603
 None
 0.70A 5ybbB-4av6A:
3.4		 5ybbB-4av6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 GLY A1605
GLY A1607
GLU A 931
ASN A1600
 None
 0.77A 5ybbB-4aygA:
undetectable		 5ybbB-4aygA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 GLY A 207
GLY A 198
GLU A 201
THR A 431
 None
 0.77A 5ybbB-4c7gA:
undetectable		 5ybbB-4c7gA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF01869
(BcrAD_BadFG) 		4 PHE A  89
ALA A  84
GLY A  86
GLY A 244
 None
ACT  A 305 ( 3.3A)
None
None
 0.80A 5ybbB-4ehtA:
undetectable		 5ybbB-4ehtA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		4 ALA A  64
GLY A 261
GLU A 112
ASN A  13
 CEY  A 400 (-3.6A)
None
CEY  A 400 (-3.0A)
CEY  A 400 (-3.7A)
 0.78A 5ybbB-4gizA:
undetectable		 5ybbB-4gizA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		4 ALA A 139
GLY A 135
GLY A 132
ASN A 144
 None
 0.76A 5ybbB-4il5A:
undetectable		 5ybbB-4il5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 ALA A  83
GLY A  85
GLY A  89
ASN A  61
 None
PO4  A 401 (-3.4A)
None
None
 0.72A 5ybbB-4lvqA:
undetectable		 5ybbB-4lvqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		4 PHE A 151
ALA A 156
GLY A  74
THR A 172
 None
 0.80A 5ybbB-4lz6A:
undetectable		 5ybbB-4lz6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		4 GLY A 549
GLY A 144
GLU A 385
ASN A 586
 None
None
None
FDA  A 801 (-3.3A)
 0.78A 5ybbB-4mifA:
undetectable		 5ybbB-4mifA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		4 ALA A 222
GLY A 220
GLY A 194
ASN A 243
 None
 0.82A 5ybbB-4muoA:
undetectable		 5ybbB-4muoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oog RIBONUCLEASE 3

(Saccharomyces
cerevisiae) 		PF00035
(dsrm)
PF00636
(Ribonuclease_3) 		4 ALA C 428
GLY C 424
GLY C 415
ASN C 369
 None
None
None
G  D  14 ( 4.4A)
 0.79A 5ybbB-4oogC:
undetectable		 5ybbB-4oogC:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pys BETA-N-ACETYLHEXOSAM
INIDASE

(Bacteroides
fragilis) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 ALA A 242
GLY A 183
GLY A 185
GLU A 243
 None
 0.76A 5ybbB-4pysA:
undetectable		 5ybbB-4pysA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 4 PHE B 211
ALA B 216
ASN B 221
THR B 220
 None
 0.78A 5ybbB-4qezB:
undetectable		 5ybbB-4qezB:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		4 GLY A2809
GLY A2811
GLU A2127
ASN A2804
 None
 0.79A 5ybbB-4tvcA:
undetectable		 5ybbB-4tvcA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6v DI-/TRIPEPTIDE
TRANSPORTER

(Yersinia
enterocolitica) 		PF00854
(PTR2) 		4 ALA A 262
GLY A  66
GLY A  70
ASN A 257
 None
 0.71A 5ybbB-4w6vA:
2.6		 5ybbB-4w6vA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 373
GLY A 374
GLY A 376
THR A 132
 None
 0.73A 5ybbB-4wumA:
undetectable		 5ybbB-4wumA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 GLY A 906
GLY A 908
GLU A 944
THR A 982
 None
 0.57A 5ybbB-4xqkA:
20.9		 5ybbB-4xqkA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz8 NUCLEOPROTEIN

(Thiafora
orthonairovirus) 		PF02477
(Nairo_nucleo) 		4 ALA A  74
GLY A 401
ASN A  32
THR A  31
 None
 0.75A 5ybbB-4xz8A:
undetectable		 5ybbB-4xz8A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 376
GLY A 377
GLY A 379
THR A 135
 None
 0.67A 5ybbB-4yjyA:
undetectable		 5ybbB-4yjyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztk CELL DIVISION
PROTEIN
FTSI/PENICILLIN
BINDING PROTEIN 2

(Legionella
pneumophila) 		PF00905
(Transpeptidase) 		4 ALA A 620
GLY A 615
GLY A 570
ASN A 625
 None
NHE  A 901 ( 4.7A)
NHE  A 901 (-3.6A)
None
 0.81A 5ybbB-4ztkA:
undetectable		 5ybbB-4ztkA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		4 ALA A  53
GLY A  55
GLY A  57
GLU A  74
 SAH  A 301 (-3.3A)
SAH  A 301 ( 3.7A)
None
SAH  A 301 (-2.9A)
 0.72A 5ybbB-5bszA:
9.2		 5ybbB-5bszA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb5 O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Escherichia
coli) 		no annotation 4 ALA R  37
GLY R  33
GLY R  31
THR R  13
 APR  R 201 ( 3.8A)
APR  R 201 (-3.4A)
APR  R 201 (-3.6A)
None
 0.79A 5ybbB-5cb5R:
undetectable		 5ybbB-5cb5R:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cec BD3460

(Bdellovibrio
bacteriovorus) 		PF12796
(Ank_2) 		4 PHE B 102
ALA B 112
GLY B  74
THR B 145
 None
 0.81A 5ybbB-5cecB:
undetectable		 5ybbB-5cecB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE

(Sulfolobus
islandicus) 		PF13847
(Methyltransf_31) 		4 GLY A  38
GLY A  40
GLU A  59
ASN A  87
 SAH  A 201 (-3.5A)
None
SAH  A 201 (-2.9A)
SAH  A 201 (-3.7A)
 0.53A 5ybbB-5fadA:
10.6		 5ybbB-5fadA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		4 GLY A 906
GLY A 908
GLU A 944
THR A 982
 None
 0.74A 5ybbB-5ffjA:
20.8		 5ybbB-5ffjA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 702
GLY A 704
GLY A 188
GLU A 703
THR A 691
 None
 1.43A 5ybbB-5fp1A:
undetectable		 5ybbB-5fp1A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsz MACRODOMAIN

(Trypanosoma
cruzi) 		PF01661
(Macro) 		4 ALA A 127
GLY A 123
GLY A 121
THR A 103
 None
 0.82A 5ybbB-5fszA:
undetectable		 5ybbB-5fszA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7t CLASS IV CHITINASE

(Cryptomeria
japonica) 		no annotation 4 PHE A  70
ALA A  19
GLY A  24
GLY A  26
 None
 0.67A 5ybbB-5h7tA:
undetectable		 5ybbB-5h7tA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 5 ALA C 363
GLY C 365
GLY C 367
GLU C 413
ASN C 460
 SFG  C1002 (-3.9A)
SFG  C1002 (-3.4A)
None
SFG  C1002 (-2.8A)
SFG  C1002 (-3.2A)
 0.74A 5ybbB-5hr4C:
16.9		 5ybbB-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA

(Lactobacillus
plantarum) 		PF09861
(DUF2088) 		4 GLY A 418
GLY A 420
ASN A 307
THR A 306
 None
 0.74A 5ybbB-5huqA:
undetectable		 5ybbB-5huqA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ALA A 231
GLY A 229
GLY A 227
ASN A 253
 None
 0.80A 5ybbB-5ie2A:
undetectable		 5ybbB-5ie2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkx TBPB

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C) 		4 PHE A 605
ALA A 499
GLY A 487
THR A 421
 None
 0.69A 5ybbB-5kkxA:
undetectable		 5ybbB-5kkxA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldx NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11

(Bos taurus) 		PF02466
(Tim17) 		4 PHE Y  69
ALA Y  64
GLY Y  66
GLY Y  28
 None
 0.82A 5ybbB-5ldxY:
undetectable		 5ybbB-5ldxY:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP3

(Parechovirus A;
Parechovirus A) 		no annotation
no annotation 		4 PHE A  78
ALA A  75
GLY A 101
THR B  43
 None
 0.74A 5ybbB-5mjvA:
undetectable		 5ybbB-5mjvA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mog PHYTOENE
DEHYDROGENASE,
CHLOROPLASTIC/CHROMO
PLASTIC

(Oryza sativa) 		PF01593
(Amino_oxidase) 		4 ALA A 529
GLY A 116
GLY A 111
THR A 533
 None
None
FAD  A 600 (-3.2A)
None
 0.80A 5ybbB-5mogA:
undetectable		 5ybbB-5mogA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5noa FAMILY 88 GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF07470
(Glyco_hydro_88) 		5 ALA A  68
GLY A  64
GLY A 362
ASN A  73
THR A  72
 None
 1.48A 5ybbB-5noaA:
undetectable		 5ybbB-5noaA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 PHE A 373
GLY A 374
GLY A 376
THR A 132
 None
 0.69A 5ybbB-5uc5A:
undetectable		 5ybbB-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk4 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Neisseria
gonorrhoeae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ALA A 125
GLY A 123
GLY A  82
THR A  31
 None
 0.72A 5ybbB-5vk4A:
undetectable		 5ybbB-5vk4A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn7 PUTATIVE RTX-TOXIN

(Vibrio
vulnificus) 		PF11647
(MLD) 		5 ALA A2811
GLY A2603
GLY A2601
GLU A2572
ASN A2565
 None
 1.21A 5ybbB-5xn7A:
undetectable		 5ybbB-5xn7A:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 7 PHE A 171
ALA A 197
GLY A 199
GLY A 202
GLU A 233
ASN A 260
THR A 261
 None
SAM  A 601 (-3.0A)
SAM  A 601 (-3.3A)
SAM  A 601 (-3.0A)
SAM  A 601 (-2.7A)
SAM  A 601 (-2.9A)
SAM  A 601 (-3.8A)
 0.21A 5ybbB-5ybbA:
59.0		 5ybbB-5ybbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys3 SUCCINATE-ACETATE
PERMEASE

(Citrobacter
koseri) 		no annotation 4 PHE A  17
ALA A  49
GLY A  46
GLY A  42
 ACT  A 203 ( 3.6A)
None
None
None
 0.77A 5ybbB-5ys3A:
undetectable		 5ybbB-5ys3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE

(Helicobacter
pylori) 		no annotation 4 PHE A  85
ALA A  78
GLY A  82
ASN A 117
 None
 0.81A 5ybbB-6ck0A:
undetectable		 5ybbB-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 4 ALA B  46
GLY B  56
GLY B  82
GLU B  28
 None
 0.82A 5ybbB-6ckcB:
undetectable		 5ybbB-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 PHE A 374
GLY A 375
GLY A 377
THR A 132
 None
 0.81A 5ybbB-6co0A:
undetectable		 5ybbB-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 4 ALA A 403
GLY A  17
GLY A  12
THR A 407
 None
None
FAD  A 507 (-3.4A)
None
 0.73A 5ybbB-6cr0A:
undetectable		 5ybbB-6cr0A:
21.22