SIMILAR PATTERNS OF AMINO ACIDS FOR 5YBB_A_SAMA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 PHE A 314
THR A 316
ASP A  30
GLU A 313
 None
None
GDP  A 500 (-4.3A)
None
 1.37A 5ybbA-1dj3A:
0.0		 5ybbA-1dj3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjn MTH0777

(Methanothermobacter
thermautotrophicus) 		PF09001
(DUF1890) 		4 PHE A  37
THR A  40
ASP A  78
GLU A  80
 None
 1.46A 5ybbA-1kjnA:
undetectable		 5ybbA-1kjnA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqs SLY1 PROTEIN

(Saccharomyces
cerevisiae) 		PF00995
(Sec1) 		4 PHE A  46
THR A  42
ASP A  36
ASN A  29
 None
 1.32A 5ybbA-1mqsA:
undetectable		 5ybbA-1mqsA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okc ADP, ATP CARRIER
PROTEIN HEART
ISOFORM T1

(Bos taurus) 		PF00153
(Mito_carr) 		4 PHE A 129
THR A  83
ASP A 134
ASN A 177
 None
CXT  A 401 ( 3.9A)
CXT  A 401 ( 4.7A)
CDL  A 802 (-3.0A)
 1.00A 5ybbA-1okcA:
undetectable		 5ybbA-1okcA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 PHE A 280
THR A 142
GLU A 284
ASN A 288
 None
 1.29A 5ybbA-1orrA:
4.8		 5ybbA-1orrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcg THIOGLUCOSIDASE

(Brevicoryne
brassicae) 		PF00232
(Glyco_hydro_1) 		4 PHE A 455
THR A 453
ASP A 385
ASN A 421
 None
 1.41A 5ybbA-1wcgA:
undetectable		 5ybbA-1wcgA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bty ACETYLGLUTAMATE
KINASE

(Thermotoga
maritima) 		PF00696
(AA_kinase) 		4 PHE A  28
THR A 201
ASP A 182
ASN A 178
 None
None
NLG  A1284 (-3.4A)
None
 1.49A 5ybbA-2btyA:
1.0		 5ybbA-2btyA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cir HEXOSE-6-PHOSPHATE
MUTAROTASE

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		4 PHE A 105
THR A  89
ASP A   7
GLU A   5
 None
 1.42A 5ybbA-2cirA:
undetectable		 5ybbA-2cirA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		4 THR A 190
ASP A 125
GLU A  25
ASN A  78
 None
 1.41A 5ybbA-2is3A:
undetectable		 5ybbA-2is3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		4 PHE A  94
ASP B 347
GLU A 107
ASN B 224
 SF4  A1984 (-4.6A)
GOL  B1353 (-4.2A)
None
SF4  B1359 (-4.1A)
 1.44A 5ybbA-2ivfA:
1.3		 5ybbA-2ivfA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mqw 26S PROTEASOME
REGULATORY SUBUNIT
RPN9

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A  26
THR A  13
ASP A   8
GLU A  30
 None
 1.23A 5ybbA-2mqwA:
undetectable		 5ybbA-2mqwA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		4 PHE A 152
THR A 157
GLU A 149
ASN A  23
 HEM  A 401 (-4.8A)
None
None
None
 1.30A 5ybbA-2nwbA:
undetectable		 5ybbA-2nwbA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum) 		PF00294
(PfkB) 		4 PHE A 116
THR A  84
ASP A  80
ASN A  42
 None
 1.43A 5ybbA-2nwhA:
undetectable		 5ybbA-2nwhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 PHE B 304
THR B 273
GLU B 239
ASN B 351
 None
 1.49A 5ybbA-2q2eB:
undetectable		 5ybbA-2q2eB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF02390
(Methyltransf_4) 		5 PHE E 106
THR E 259
ASP E 101
GLU E 126
ASN E 161
 None
SAM  E1287 (-2.8A)
SAM  E1287 ( 4.9A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.4A)
 1.24A 5ybbA-2vdvE:
6.2		 5ybbA-2vdvE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG

(Pseudomonas
aeruginosa) 		PF03922
(OmpW) 		4 PHE X  10
THR X  51
ASP X 156
ASN X 160
 None
 1.42A 5ybbA-2x27X:
undetectable		 5ybbA-2x27X:
16.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 THR B 151
ASP B 173
GLU B 216
ASN B 248
 None
 0.72A 5ybbA-2y7cB:
30.5		 5ybbA-2y7cB:
31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeh HEMOGLOBIN-BINDING
PROTEASE HBP
AUTOTRANSPORTER

(Escherichia
coli) 		PF03797
(Autotransporter) 		4 THR A1290
ASP A1108
GLU A1245
ASN A1101
 None
 1.42A 5ybbA-3aehA:
undetectable		 5ybbA-3aehA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c75 METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN
METHYLAMINE
DEHYDROGENASE LIGHT
CHAIN

(Paracoccus
versutus;
Paracoccus
versutus) 		PF06433
(Me-amine-dh_H)
PF02975
(Me-amine-dh_L) 		4 PHE L 102
THR L  91
ASP L 105
ASN H 235
 None
 1.01A 5ybbA-3c75L:
undetectable		 5ybbA-3c75L:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckk TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Homo sapiens) 		PF02390
(Methyltransf_4) 		4 THR A 208
ASP A  52
GLU A  77
ASN A 110
 SAM  A 301 (-2.8A)
SAM  A 301 ( 4.9A)
SAM  A 301 (-2.7A)
SAM  A 301 (-3.5A)
 1.06A 5ybbA-3ckkA:
4.9		 5ybbA-3ckkA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 PHE A 371
THR A 329
ASP A 361
ASN A  62
 None
None
CA  A   1 (-3.0A)
None
 1.08A 5ybbA-3evrA:
undetectable		 5ybbA-3evrA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fho ATP-DEPENDENT RNA
HELICASE DBP5

(Schizosaccharomyces
pombe) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 PHE A 296
THR A 318
GLU A 313
ASN A 310
 None
 1.47A 5ybbA-3fhoA:
undetectable		 5ybbA-3fhoA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gqm CELL INHIBITING
FACTOR (CIFBP)

(Burkholderia
pseudomallei) 		PF16374
(CIF) 		4 PHE A  98
THR A 111
ASP A  45
GLU A 103
 None
 1.36A 5ybbA-3gqmA:
undetectable		 5ybbA-3gqmA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i24 HIT FAMILY HYDROLASE

(Aliivibrio
fischeri) 		PF01230
(HIT) 		4 PHE A  58
THR A  51
GLU A  61
ASN A  18
 None
 1.30A 5ybbA-3i24A:
undetectable		 5ybbA-3i24A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Aquifex
aeolicus) 		PF04551
(GcpE) 		4 PHE A 163
THR A 169
ASP A 195
ASN A 187
 None
 1.29A 5ybbA-3noyA:
undetectable		 5ybbA-3noyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 PHE A 267
THR A 195
ASP A 138
ASN A 117
 None
 1.10A 5ybbA-3ooxA:
undetectable		 5ybbA-3ooxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 PHE A 185
THR A 147
ASP A 153
ASN A 117
 None
 1.50A 5ybbA-3zyxA:
undetectable		 5ybbA-3zyxA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 THR A 404
ASP A 475
GLU A 460
ASN A 138
 None
None
UML  A 598 (-3.1A)
None
 1.39A 5ybbA-4c13A:
2.2		 5ybbA-4c13A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 THR A 177
ASP A 157
GLU A 170
ASN A 432
 None
 1.41A 5ybbA-4c23A:
undetectable		 5ybbA-4c23A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 PHE A 247
THR A 660
GLU A 264
ASN A 437
 None
 1.28A 5ybbA-4db1A:
0.7		 5ybbA-4db1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fms PROBABLE PORIN

(Pseudomonas
aeruginosa) 		no annotation 4 PHE B 324
THR B 264
GLU B 351
ASN B 365
 C8E  B 407 (-3.9A)
None
None
None
 1.38A 5ybbA-4fmsB:
undetectable		 5ybbA-4fmsB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 PHE A  55
THR A  57
ASP A  36
GLU A  21
 None
 1.34A 5ybbA-4g2nA:
4.9		 5ybbA-4g2nA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH)
PF00788
(RA) 		4 PHE A 327
THR A 292
GLU A 328
ASN A 498
 MLI  A 601 (-4.8A)
None
None
None
 1.24A 5ybbA-4gn1A:
undetectable		 5ybbA-4gn1A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ieg RNA-DEPENDENT RNA
POLYMERASE P2

(Pseudomonas
phage phi12) 		no annotation 4 PHE A 347
ASP A 469
GLU A 503
ASN A 253
 None
None
MG  A1001 (-2.3A)
None
 1.48A 5ybbA-4iegA:
0.4		 5ybbA-4iegA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuj PROTEIN KINASE,
PUTATIVE

(Entamoeba
histolytica) 		PF02816
(Alpha_kinase) 		4 PHE A 250
THR A 252
ASP A 176
ASN A 240
 None
 1.13A 5ybbA-4kujA:
undetectable		 5ybbA-4kujA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		4 THR A 545
ASP A 220
GLU A 226
ASN A 252
 None
 1.02A 5ybbA-4kvoA:
undetectable		 5ybbA-4kvoA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyl URACIL-DNA
GLYCOSYLASE

(Gadus morhua) 		PF03167
(UDG) 		4 PHE A 242
THR A 255
ASP A 227
ASN A 204
 None
 1.44A 5ybbA-4lylA:
undetectable		 5ybbA-4lylA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 PHE A1481
THR A1484
GLU A1496
ASN A1843
 None
 1.32A 5ybbA-4o9xA:
undetectable		 5ybbA-4o9xA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 THR A 384
ASP A  77
GLU A  46
ASN A  41
 None
 1.46A 5ybbA-4oy4A:
undetectable		 5ybbA-4oy4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0s L-RIBOSE ISOMERASE

(Acinetobacter
sp. DL-28) 		no annotation 4 PHE A 234
THR A 241
ASP A  45
GLU A  61
 None
 1.12A 5ybbA-4q0sA:
undetectable		 5ybbA-4q0sA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT II,
CHLOROPLASTIC

(Pisum sativum;
Pisum sativum) 		PF00223
(PsaA_PsaB)
PF02531
(PsaD) 		4 PHE D 113
ASP A 423
GLU D 114
ASN A 574
 None
 1.21A 5ybbA-4rkuD:
undetectable		 5ybbA-4rkuD:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umz CYTOCHROME P450
HYDROXYLASE PIKC

(Streptomyces
venezuelae) 		PF00067
(p450) 		4 PHE A 178
THR A 189
ASP A 183
ASN A  50
 None
 1.40A 5ybbA-4umzA:
0.7		 5ybbA-4umzA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		4 PHE A 228
THR A 206
ASP A 210
GLU A 227
 None
 1.42A 5ybbA-4wjsA:
undetectable		 5ybbA-4wjsA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 PHE A 349
THR A 302
ASP A 344
ASN A 176
 None
None
GH3  A 503 (-2.9A)
GH3  A 504 ( 4.8A)
 1.45A 5ybbA-4xj6A:
undetectable		 5ybbA-4xj6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2h HA-33

(Clostridium
botulinum) 		PF14200
(RicinB_lectin_2) 		4 PHE A 231
THR A 243
GLU A  13
ASN A   7
 None
 1.30A 5ybbA-5b2hA:
undetectable		 5ybbA-5b2hA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		4 PHE A  76
THR A 189
GLU A 230
ASN A  10
 None
 1.48A 5ybbA-5eyyA:
undetectable		 5ybbA-5eyyA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE

(Sulfolobus
islandicus) 		PF13847
(Methyltransf_31) 		4 THR A  12
ASP A  34
GLU A  59
ASN A  87
 SAH  A 201 (-3.4A)
SAH  A 201 (-2.9A)
SAH  A 201 (-2.9A)
SAH  A 201 (-3.7A)
 1.01A 5ybbA-5fadA:
10.5		 5ybbA-5fadA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkb FATTY ACID BINDIN
PROTEIN, ISOFORM B

(Drosophila
melanogaster) 		PF00061
(Lipocalin) 		4 PHE A  64
THR A  92
GLU A  72
ASN A  79
 None
 1.33A 5ybbA-5gkbA:
undetectable		 5ybbA-5gkbA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 4 THR C 316
ASP C 361
GLU C 413
ASN C 460
 SFG  C1002 (-4.0A)
SFG  C1002 ( 4.9A)
SFG  C1002 (-2.8A)
SFG  C1002 (-3.2A)
 0.53A 5ybbA-5hr4C:
16.9		 5ybbA-5hr4C:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14
F-BOX/LRR-REPEAT
MAX2 HOMOLOG

(Arabidopsis
thaliana;
Oryza sativa) 		PF12697
(Abhydrolase_6)
no annotation 		4 PHE B 709
ASP A  62
GLU B 667
ASN A  11
 None
 1.05A 5ybbA-5hzgB:
undetectable		 5ybbA-5hzgB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		4 PHE A 320
THR A  79
ASP A 324
GLU A 191
 None
 1.33A 5ybbA-5j7uA:
undetectable		 5ybbA-5j7uA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnb POLY(A) RNA
POLYMERASE GLD-2

(Caenorhabditis
elegans) 		PF03828
(PAP_assoc) 		4 PHE A 600
THR A 680
ASP A 608
ASN A 603
 None
EDO  A1005 (-3.8A)
MG  A1002 (-3.1A)
None
 1.44A 5ybbA-5jnbA:
undetectable		 5ybbA-5jnbA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A
COMPLEMENT C4-A

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
PF01759
(NTR)
PF07677
(A2M_recep) 		4 PHE B1144
THR B1196
GLU B1263
ASN C1561
 None
 1.31A 5ybbA-5jpnB:
undetectable		 5ybbA-5jpnB:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jz7 BETA-NERVE GROWTH
FACTOR
MEDI578 SCFV, HEAVY
CHAIN

(Homo sapiens;
Homo sapiens) 		PF00243
(NGF)
PF07686
(V-set) 		4 PHE A  54
THR C  31
ASP A  24
GLU A  55
 None
 1.48A 5ybbA-5jz7A:
undetectable		 5ybbA-5jz7A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		4 THR A   6
ASP A 359
GLU A  99
ASN A  71
 None
 1.37A 5ybbA-5knnA:
1.5		 5ybbA-5knnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 THR A 340
ASP A 236
GLU A 171
ASN A 174
 None
MG  A 802 ( 3.7A)
MG  A 803 (-4.3A)
None
 1.25A 5ybbA-5mdnA:
2.9		 5ybbA-5mdnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyw PROTEASOME SUBUNIT

(Yersinia
bercovieri) 		no annotation 4 PHE A 203
THR A 205
GLU A  41
ASN A  76
 None
 1.44A 5ybbA-5nywA:
undetectable		 5ybbA-5nywA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 4 PHE A  77
THR A  75
GLU A 236
ASN A 248
 None
 1.41A 5ybbA-5wknA:
undetectable		 5ybbA-5wknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
SPT4/5 COMPLEX
COMPONENT

(Komagataella
phaffii;
Komagataella
phaffii;
Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF00467
(KOW) 		4 PHE C  61
ASP B 950
GLU C  60
ASN W 786
 None
 1.40A 5ybbA-5xogC:
undetectable		 5ybbA-5xogC:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ybb TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT

(Caldanaerobacter
subterraneus) 		no annotation 5 PHE A 171
THR A 173
ASP A 195
GLU A 233
ASN A 260
 None
SAM  A 601 (-3.2A)
SAM  A 601 (-3.5A)
SAM  A 601 (-2.7A)
SAM  A 601 (-2.9A)
 0.00A 5ybbA-5ybbA:
61.7		 5ybbA-5ybbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 PHE A 112
THR A 118
ASP A  90
ASN A 495
 None
 1.26A 5ybbA-6cc2A:
undetectable		 5ybbA-6cc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 4 PHE A 247
THR A 660
GLU A 264
ASN A 437
 None
 1.43A 5ybbA-6fsaA:
undetectable		 5ybbA-6fsaA:
undetectable