SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y9Y_A_ACTA409_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 LYS A 641
PRO A 642
LYS A 664
 None
 0.94A 5y9yA-1cb8A:
0.0		 5y9yA-1cb8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		3 LYS A 119
PRO A 120
LYS A 124
 None
 1.12A 5y9yA-1de6A:
0.0		 5y9yA-1de6A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		3 LYS A  10
PRO A  12
LYS A  84
 None
 1.13A 5y9yA-1dgmA:
0.0		 5y9yA-1dgmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		3 LYS A  84
PRO A  85
LYS A  10
 None
 0.81A 5y9yA-1dgmA:
0.0		 5y9yA-1dgmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		3 LYS A   8
PRO A   9
LYS A  11
 None
 0.84A 5y9yA-1dqpA:
0.0		 5y9yA-1dqpA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		3 LYS A  75
PRO A  75
LYS A  77
 None
 0.92A 5y9yA-1fizA:
0.0		 5y9yA-1fizA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		3 LYS A  44
PRO A  45
LYS A  47
 None
 1.08A 5y9yA-1fkkA:
0.2		 5y9yA-1fkkA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvi CHLORELLA VIRUS DNA
LIGASE-ADENYLATE

(Chlorella virus) 		PF01068
(DNA_ligase_A_M)
PF14743
(DNA_ligase_OB_2) 		3 LYS A 167
PRO A 168
LYS A 108
 None
 0.93A 5y9yA-1fviA:
0.0		 5y9yA-1fviA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		3 LYS A 246
PRO A 245
LYS A 219
 None
 1.25A 5y9yA-1gm5A:
0.0		 5y9yA-1gm5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i25 HUWENTOXIN-II

(Haplopelma
schmidti) 		PF08089
(Toxin_20) 		3 LYS A  16
PRO A  17
LYS A   1
 None
 0.84A 5y9yA-1i25A:
undetectable		 5y9yA-1i25A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuh 2'-5' RNA LIGASE

(Thermus
thermophilus) 		PF02834
(LigT_PEase) 		3 LYS A 125
PRO A 126
LYS A 128
 None
 0.68A 5y9yA-1iuhA:
0.0		 5y9yA-1iuhA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 LYS A 496
PRO A 601
LYS A 608
 None
 1.28A 5y9yA-1k72A:
undetectable		 5y9yA-1k72A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oae CYTOCHROME C'

(Methylophilus
methylotrophus) 		PF09086
(DUF1924) 		3 LYS A 121
PRO A 122
LYS A 124
 None
 1.26A 5y9yA-1oaeA:
undetectable		 5y9yA-1oaeA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocp OCT-3

(Mus musculus) 		PF00046
(Homeobox) 		3 LYS A  32
PRO A  33
LYS A  29
 None
 1.20A 5y9yA-1ocpA:
undetectable		 5y9yA-1ocpA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1u FIBROBLAST GROWTH
FACTOR HOMOLOGOUS
FACTOR 1

(Homo sapiens) 		PF00167
(FGF) 		3 LYS A 131
PRO A 132
LYS A 117
 SO4  A 439 (-4.6A)
SO4  A 439 (-3.7A)
None
 1.03A 5y9yA-1q1uA:
undetectable		 5y9yA-1q1uA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12

(Homo sapiens) 		PF00621
(RhoGEF) 		3 LYS A 782
PRO A 783
LYS A 787
 None
 1.26A 5y9yA-1txdA:
undetectable		 5y9yA-1txdA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		3 LYS B 290
PRO B 291
LYS B 261
 None
 1.21A 5y9yA-1wdwB:
undetectable		 5y9yA-1wdwB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajz ANTIBODY 7A1 FAB'

(Mus musculus) 		no annotation 3 LYS L 142
PRO L 141
LYS L 107
 None
 0.74A 5y9yA-2ajzL:
undetectable		 5y9yA-2ajzL:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkd FRAGILE X MENTAL
RETARDATION 1
PROTEIN

(Homo sapiens) 		PF05641
(Agenet) 		3 LYS N 119
PRO N 120
LYS N 123
 None
 0.97A 5y9yA-2bkdN:
undetectable		 5y9yA-2bkdN:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bug SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00515
(TPR_1)
PF13181
(TPR_8) 		3 LYS A 126
PRO A 127
LYS A 133
 None
 1.23A 5y9yA-2bugA:
undetectable		 5y9yA-2bugA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4i AVIDIN

(Gallus gallus) 		PF01382
(Avidin) 		3 LYS A   5
PRO A   7
LYS A  82
 None
 1.09A 5y9yA-2c4iA:
undetectable		 5y9yA-2c4iA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 LYS A 115
PRO A 116
LYS A 122
 None
 1.27A 5y9yA-2caiA:
undetectable		 5y9yA-2caiA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d37 HYPOTHETICAL
NADH-DEPENDENT FMN
OXIDOREDUCTASE

(Sulfurisphaera
tokodaii) 		PF01613
(Flavin_Reduct) 		3 LYS A  82
PRO A  83
LYS A  85
 None
 1.19A 5y9yA-2d37A:
undetectable		 5y9yA-2d37A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db6 SH3 AND CYSTEINE
RICH DOMAIN 3

(Homo sapiens) 		PF00130
(C1_1) 		3 LYS A  16
PRO A  17
LYS A  19
 None
 0.83A 5y9yA-2db6A:
undetectable		 5y9yA-2db6A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0w GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Escherichia
coli) 		PF01019
(G_glu_transpept) 		3 LYS A  29
PRO A  31
LYS A 313
 None
 1.11A 5y9yA-2e0wA:
undetectable		 5y9yA-2e0wA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwr DNA-BINDING RESPONSE
REGULATOR MTRA

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 LYS A 168
PRO A 169
LYS A 224
 None
 1.27A 5y9yA-2gwrA:
undetectable		 5y9yA-2gwrA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hek HYPOTHETICAL PROTEIN

(Aquifex
aeolicus) 		PF01966
(HD) 		3 LYS A 347
PRO A 348
LYS A 350
 None
 1.04A 5y9yA-2hekA:
undetectable		 5y9yA-2hekA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsz NOVEL PREDICTED
PHOSPHATASE

(Histophilus
somni) 		PF13419
(HAD_2) 		3 LYS A 120
PRO A 121
LYS A 123
 UNL  A 227 (-3.0A)
UNL  A 227 (-4.2A)
UNL  A 227 (-3.7A)
 1.22A 5y9yA-2hszA:
undetectable		 5y9yA-2hszA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iew INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Saccharomyces
cerevisiae) 		PF03770
(IPK) 		3 LYS A 126
PRO A 127
LYS A 171
 None
 1.16A 5y9yA-2iewA:
undetectable		 5y9yA-2iewA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kku UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF04033
(DUF365) 		3 LYS A 122
PRO A 123
LYS A 125
 None
 0.76A 5y9yA-2kkuA:
undetectable		 5y9yA-2kkuA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8s AGR_C_984P

(Agrobacterium
fabrum) 		PF06748
(DUF1217) 		3 LYS A 205
PRO A 207
LYS A 210
 None
 1.26A 5y9yA-2o8sA:
undetectable		 5y9yA-2o8sA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2od6 HYPOTHETICAL PROTEIN

(uncultured
marine organism) 		no annotation 3 LYS A   5
PRO A   4
LYS A   0
 None
 1.13A 5y9yA-2od6A:
undetectable		 5y9yA-2od6A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox8 SCAVENGER RECEPTOR
WITH C-TYPE LECTIN
TYPE I

(Homo sapiens) 		PF00059
(Lectin_C) 		3 LYS A 606
PRO A 608
LYS A 732
 None
 1.25A 5y9yA-2ox8A:
undetectable		 5y9yA-2ox8A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p12 HYPOTHETICAL PROTEIN
DUF402

(Rhodococcus
jostii) 		PF04167
(DUF402) 		3 LYS A  12
PRO A  11
LYS A   8
 None
 1.30A 5y9yA-2p12A:
undetectable		 5y9yA-2p12A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2py2 ANTIFREEZE PROTEIN
TYPE II

(Clupea harengus) 		PF00059
(Lectin_C) 		3 LYS A 127
PRO A 128
LYS A 130
 None
 0.90A 5y9yA-2py2A:
undetectable		 5y9yA-2py2A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9q DNA REPLICATION
COMPLEX GINS PROTEIN
PSF1

(Homo sapiens) 		no annotation 3 LYS C 141
PRO C 142
LYS C 144
 None
 0.76A 5y9yA-2q9qC:
undetectable		 5y9yA-2q9qC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		3 LYS A 262
PRO A 261
LYS A  62
 None
 1.10A 5y9yA-2qxlA:
undetectable		 5y9yA-2qxlA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rh7 GREEN FLUORESCENT
PROTEIN

(Renilla
reniformis) 		PF01353
(GFP) 		3 LYS A 116
PRO A  13
LYS A  15
 None
 1.16A 5y9yA-2rh7A:
undetectable		 5y9yA-2rh7A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgi PYRUVATE KINASE
ISOZYMES R/L

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		3 LYS A 365
PRO A 366
LYS A 309
 None
 1.27A 5y9yA-2vgiA:
undetectable		 5y9yA-2vgiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4d PHOSPHOLYSINE
PHOSPHOHISTIDINE
INORGANIC
PYROPHOSPHATE
PHOSPHATASE

(Homo sapiens) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 LYS A 189
PRO A 190
LYS A 155
 POP  A 500 (-2.9A)
None
None
 1.18A 5y9yA-2x4dA:
undetectable		 5y9yA-2x4dA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxa FAR-RED FLUORESCENT
PROTEIN MKATE

(Entacmaea
quadricolor) 		PF01353
(GFP) 		3 LYS A 182
PRO A 183
LYS A 185
 None
 1.06A 5y9yA-3bxaA:
undetectable		 5y9yA-3bxaA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6j PUTATIVE HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
fragilis) 		PF13419
(HAD_2) 		3 LYS A 142
PRO A 143
LYS A  48
 PO4  A 251 (-2.9A)
None
None
 1.26A 5y9yA-3d6jA:
undetectable		 5y9yA-3d6jA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		3 LYS A 390
PRO A 389
LYS A 387
 None
 1.21A 5y9yA-3gecA:
undetectable		 5y9yA-3gecA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		3 LYS A 996
PRO A 997
LYS A 999
 None
 1.01A 5y9yA-3hmjA:
undetectable		 5y9yA-3hmjA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		3 LYS B 425
PRO B 426
LYS A 436
 None
 1.26A 5y9yA-3jb9B:
undetectable		 5y9yA-3jb9B:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyl TELOMERASE REVERSE
TRANSCRIPTASE

(Tribolium
castaneum) 		PF00078
(RVT_1)
PF12009
(Telomerase_RBD) 		3 LYS A 260
PRO A 262
LYS A 266
 None
 1.11A 5y9yA-3kylA:
undetectable		 5y9yA-3kylA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		3 LYS A 201
PRO A 202
LYS A 205
 None
 1.20A 5y9yA-3l6rA:
undetectable		 5y9yA-3l6rA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lzx FERREDOXIN--NADP
REDUCTASE 2

(Bacillus
subtilis) 		PF07992
(Pyr_redox_2) 		3 LYS A 125
PRO A 126
LYS A 128
 None
 1.05A 5y9yA-3lzxA:
undetectable		 5y9yA-3lzxA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 3 LYS A  66
PRO A  67
LYS A  59
 None
 1.29A 5y9yA-3n6zA:
undetectable		 5y9yA-3n6zA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbp NUCLEOPORIN
NUP116/NSP116

(Saccharomyces
cerevisiae) 		PF04096
(Nucleoporin2) 		3 LYS B1067
PRO B1068
LYS B1070
 None
 1.19A 5y9yA-3pbpB:
undetectable		 5y9yA-3pbpB:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 LIGHT CHAIN

(Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS L 142
PRO L 141
LYS L 107
 None
 0.87A 5y9yA-3r08L:
undetectable		 5y9yA-3r08L:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rao PUTATIVE
LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		3 LYS A 172
PRO A 171
LYS A  96
 None
 1.31A 5y9yA-3raoA:
undetectable		 5y9yA-3raoA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwa FLUORESCENT PROTEIN
FP480

(Entacmaea
quadricolor) 		PF01353
(GFP) 		3 LYS A  15
PRO A  16
LYS A  18
 None
 1.00A 5y9yA-3rwaA:
undetectable		 5y9yA-3rwaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3r CATHEPSIN B-LIKE
PEPTIDASE (C01
FAMILY)

(Schistosoma
mansoni) 		PF00112
(Peptidase_C1) 		3 LYS A 177
PRO A 176
LYS A 164
 None
 1.15A 5y9yA-3s3rA:
undetectable		 5y9yA-3s3rA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 LYS A  89
PRO A  90
LYS A  65
 None
 1.17A 5y9yA-3wigA:
undetectable		 5y9yA-3wigA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		3 LYS A 579
PRO A 580
LYS A 604
 None
 0.67A 5y9yA-3wsyA:
undetectable		 5y9yA-3wsyA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		3 LYS E 882
PRO E 883
LYS E 887
 None
 1.30A 5y9yA-4a0lE:
undetectable		 5y9yA-4a0lE:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv1 NEQ011

(Nanoarchaeum
equitans) 		PF01880
(Desulfoferrodox) 		3 LYS A  78
PRO A  77
LYS A  34
 None
 1.31A 5y9yA-4bv1A:
undetectable		 5y9yA-4bv1A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7r PROLINE/BETAINE
TRANSPORTER, RALF

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		3 LYS A 188
PRO A 189
LYS A 191
 None
 1.18A 5y9yA-4d7rA:
undetectable		 5y9yA-4d7rA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etv RYANODINE RECEPTOR 2

(Mus musculus) 		PF02026
(RyR) 		3 LYS A2757
PRO A2758
LYS A2760
 None
 0.81A 5y9yA-4etvA:
undetectable		 5y9yA-4etvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		3 LYS A 256
PRO A 257
LYS A 261
 None
 1.11A 5y9yA-4eysA:
undetectable		 5y9yA-4eysA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis) 		PF01979
(Amidohydro_1) 		3 LYS A 120
PRO A 453
LYS A  84
 None
 1.21A 5y9yA-4gz7A:
undetectable		 5y9yA-4gz7A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		3 LYS A  44
PRO A  45
LYS A  47
 None
 0.97A 5y9yA-4iqcA:
undetectable		 5y9yA-4iqcA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		3 LYS A 603
PRO A 604
LYS A 606
 None
 1.19A 5y9yA-4mmhA:
undetectable		 5y9yA-4mmhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opf NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 LYS A6442
PRO A6443
LYS A6326
 None
 1.31A 5y9yA-4opfA:
undetectable		 5y9yA-4opfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozs ALPHA SOLENOID
PROTEIN

(synthetic
construct) 		PF12854
(PPR_1)
PF13041
(PPR_2) 		3 LYS A  69
PRO A  70
LYS A 101
 None
 0.96A 5y9yA-4ozsA:
undetectable		 5y9yA-4ozsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozs ALPHA SOLENOID
PROTEIN

(synthetic
construct) 		PF12854
(PPR_1)
PF13041
(PPR_2) 		3 LYS A 104
PRO A 105
LYS A 136
 None
 0.80A 5y9yA-4ozsA:
undetectable		 5y9yA-4ozsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pkh GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin)
PF03250
(Tropomodulin) 		3 LYS B1059
PRO B1061
LYS B1063
 None
 1.02A 5y9yA-4pkhB:
undetectable		 5y9yA-4pkhB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7k ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		3 LYS A 357
PRO A 358
LYS A 517
 None
 0.96A 5y9yA-4q7kA:
undetectable		 5y9yA-4q7kA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3i YTH
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF04146
(YTH) 		3 LYS A 469
PRO A 470
LYS A 472
 UNX  A 604 ( 3.1A)
None
U  B   5 ( 2.8A)
 0.92A 5y9yA-4r3iA:
undetectable		 5y9yA-4r3iA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		3 LYS A 339
PRO A 340
LYS A 317
 None
 1.26A 5y9yA-4tmcA:
undetectable		 5y9yA-4tmcA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v19 MITORIBOSOMAL
PROTEIN UL30M,
MRPL30

(Sus scrofa) 		PF00327
(Ribosomal_L30) 		3 LYS 3 120
PRO 3 121
LYS 3 123
 None
 1.29A 5y9yA-4v193:
undetectable		 5y9yA-4v193:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgm MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 3

(Homo sapiens) 		PF16953
(PRORP) 		3 LYS A 478
PRO A 480
LYS A 386
 None
 1.29A 5y9yA-4xgmA:
undetectable		 5y9yA-4xgmA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9t ABC TRANSPORTER,
SOLUTE BINDING
PROTEIN

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		3 LYS A 289
PRO A 290
LYS A 292
 None
 1.09A 5y9yA-4y9tA:
undetectable		 5y9yA-4y9tA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		3 LYS A 331
PRO A 330
LYS A 327
 None
 1.19A 5y9yA-4yh7A:
undetectable		 5y9yA-4yh7A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chv UBL
CARBOXYL-TERMINAL
HYDROLASE 18

(Mus musculus) 		PF00443
(UCH) 		3 LYS A 201
PRO A 202
LYS A 204
 None
None
CL  A 403 ( 4.6A)
 0.94A 5y9yA-5chvA:
undetectable		 5y9yA-5chvA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecj PR DOMAIN ZINC
FINGER PROTEIN
14,PROTEIN CBFA2T2

(Mus musculus) 		PF00856
(SET)
PF07531
(TAFH) 		3 LYS A 178
PRO A 183
LYS A 210
 None
 1.32A 5y9yA-5ecjA:
undetectable		 5y9yA-5ecjA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fly FERRICHROME-BINDING
PERIPLASMIC PROTEIN

(Staphylococcus
pseudintermedius) 		PF01497
(Peripla_BP_2) 		3 LYS A 208
PRO A 207
LYS A 167
 CL  A1287 (-4.5A)
CL  A1290 (-4.7A)
None
 1.29A 5y9yA-5flyA:
undetectable		 5y9yA-5flyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 LYS A  19
PRO A  20
LYS A  22
 None
 1.32A 5y9yA-5h53A:
undetectable		 5y9yA-5h53A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm7 BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		3 LYS A 425
PRO A 426
LYS A 428
 None
 0.65A 5y9yA-5hm7A:
undetectable		 5y9yA-5hm7A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwt SENSOR HISTIDINE
KINASE TODS

(Pseudomonas
putida) 		PF08448
(PAS_4) 		3 LYS A  77
PRO A  78
LYS A  81
 None
 1.21A 5y9yA-5hwtA:
undetectable		 5y9yA-5hwtA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		3 LYS A 707
PRO A 708
LYS A 710
 None
 1.25A 5y9yA-5hy7A:
undetectable		 5y9yA-5hy7A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		3 LYS A  44
PRO A  45
LYS A  47
 None
 1.01A 5y9yA-5i7pA:
undetectable		 5y9yA-5i7pA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9g PENTATRICOPEPTIDE
REPEAT PROTEIN
DPPR-U8C2

(unidentified) 		PF12854
(PPR_1)
PF13041
(PPR_2) 		3 LYS C 153
PRO C 154
LYS C 185
 None
 0.97A 5y9yA-5i9gC:
undetectable		 5y9yA-5i9gC:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik8 LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1)
PF02210
(Laminin_G_2) 		3 LYS A3095
PRO A3096
LYS A3088
 None
 1.27A 5y9yA-5ik8A:
undetectable		 5y9yA-5ik8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm0 ALPHA-MANNOSIDASE,AL
PHA-MANNOSIDASE,ALPH
A-MANNOSIDASE

(Saccharomyces
cerevisiae) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 LYS A 841
PRO A 759
LYS A 776
 None
 1.07A 5y9yA-5jm0A:
undetectable		 5y9yA-5jm0A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k10 ISOCITRATE
DEHYDROGENASE [NADP]
CYTOPLASMIC

(Homo sapiens) 		PF00180
(Iso_dh) 		3 LYS A 126
PRO A 127
LYS A 203
 None
 1.24A 5y9yA-5k10A:
undetectable		 5y9yA-5k10A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k59 UNCHARACTERIZED
LEUKOCIDIN-LIKE
PROTEIN 2

(Staphylococcus
aureus) 		no annotation 3 LYS D 319
PRO D 320
LYS D 322
 None
 0.73A 5y9yA-5k59D:
undetectable		 5y9yA-5k59D:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2e GLUTAMATE RECEPTOR
IONOTROPIC,
DELTA-2,GLUTAMATE
RECEPTOR IONOTROPIC,
DELTA-2

(Rattus
norvegicus) 		PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 LYS A 463
PRO A 464
LYS A 466
 None
 0.65A 5y9yA-5l2eA:
undetectable		 5y9yA-5l2eA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lug SPINDLIN-LIKE
PROTEIN 2, ISOFORM
CRA_A

(Homo sapiens) 		PF02513
(Spin-Ssty) 		3 LYS A 235
PRO A 236
LYS A 204
 None
 1.33A 5y9yA-5lugA:
undetectable		 5y9yA-5lugA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S4

(Trypanosoma
cruzi) 		no annotation 3 LYS L  72
PRO L  73
LYS L  75
 C  E 120 ( 3.2A)
None
G  E 335 ( 3.4A)
 0.72A 5y9yA-5optL:
undetectable		 5y9yA-5optL:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9c GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Bacillus
subtilis) 		PF03009
(GDPD) 		3 LYS E 181
PRO E 182
LYS E  31
 None
 1.21A 5y9yA-5t9cE:
undetectable		 5y9yA-5t9cE:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 LYS A 506
PRO A 507
LYS A 509
 None
 0.87A 5y9yA-5weoA:
undetectable		 5y9yA-5weoA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		3 LYS A 350
PRO A 292
LYS A 288
 None
 1.27A 5y9yA-5xzbA:
undetectable		 5y9yA-5xzbA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 3 LYS A  10
PRO A 123
LYS A  15
 None
 0.91A 5y9yA-5y1aA:
undetectable		 5y9yA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh0 DRFAM20C1

(Danio rerio) 		no annotation 3 LYS A 261
PRO A 262
LYS A 264
 None
 1.08A 5y9yA-5yh0A:
undetectable		 5y9yA-5yh0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 3 LYS A 205
PRO A 207
LYS A 241
 MLY  A 204 ( 3.3A)
None
MLY  A 240 ( 3.0A)
 1.31A 5y9yA-5z5cA:
undetectable		 5y9yA-5z5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE

(Viola
canadensis) 		no annotation 3 LYS A 329
PRO A 332
LYS A 288
 None
 1.28A 5y9yA-5zbiA:
undetectable		 5y9yA-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgi ANOCTAMIN-1

(Mus musculus) 		no annotation 3 LYS A 655
PRO A 654
LYS A 737
 None
 1.25A 5y9yA-6bgiA:
undetectable		 5y9yA-6bgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g5i RNA-BINDING PROTEIN
PNO1

(Homo sapiens) 		no annotation 3 LYS x 169
PRO x 170
LYS x 172
 U  21839 ( 4.9A)
None
G  21858 ( 4.1A)
 1.03A 5y9yA-6g5ix:
undetectable		 5y9yA-6g5ix:
undetectable