SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y9M_X_NIOX401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 VAL A  14
VAL A  76
PHE A 113
ILE A 125
 None
 0.70A 5y9mX-1cvrA:
undetectable		 5y9mX-1cvrA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 217
VAL A 222
ILE A 184
ASP A 185
 None
 0.72A 5y9mX-1i41A:
undetectable		 5y9mX-1i41A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		4 VAL A  31
LYS A  44
ILE A 207
ASP A 208
 ADP  A 300 ( 4.8A)
ADP  A 300 (-2.7A)
ADP  A 300 (-4.1A)
MG  A 302 (-2.1A)
 0.62A 5y9mX-1l8tA:
8.5		 5y9mX-1l8tA:
17.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 VAL A  53
LYS A  68
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.72A 5y9mX-1m2pA:
47.9		 5y9mX-1m2pA:
70.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		5 VAL A  53
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.29A 5y9mX-1m2pA:
47.9		 5y9mX-1m2pA:
70.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A 172
LYS A 187
PHE A 246
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
ADP  A 810 ( 3.0A)
 0.37A 5y9mX-1q8yA:
27.5		 5y9mX-1q8yA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tie ERYTHRINA TRYPSIN
INHIBITOR

(Erythrina
caffra) 		PF00197
(Kunitz_legume) 		4 LEU A 154
VAL A 101
VAL A  43
ILE A  75
 None
 0.67A 5y9mX-1tieA:
undetectable		 5y9mX-1tieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.47A 5y9mX-1zaoA:
4.8		 5y9mX-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 148
VAL A 128
MET A  66
ILE A  15
 None
 0.67A 5y9mX-1zejA:
undetectable		 5y9mX-1zejA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyl HYPOTHETICAL PROTEIN
YIHE

(Escherichia
coli) 		PF01636
(APH) 		4 VAL A  41
VAL A  53
PHE A 106
ASP A 217
 None
 0.68A 5y9mX-1zylA:
7.9		 5y9mX-1zylA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 281
VAL B 294
LYS B 296
ASP B 432
 None
 0.36A 5y9mX-2a1aB:
21.7		 5y9mX-2a1aB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
ILE A 160
ASP A 161
 None
None
None
GOL  A3001 ( 3.9A)
None
 0.58A 5y9mX-2a2aA:
21.7		 5y9mX-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
VAL X  25
LYS X  39
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.6A)
 0.64A 5y9mX-2dq7X:
23.5		 5y9mX-2dq7X:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF14681
(UPRTase) 		4 VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 0.45A 5y9mX-2e55A:
undetectable		 5y9mX-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
LYS A 186
PHE A 236
ASP A 320
 None
 0.60A 5y9mX-2eu9A:
27.5		 5y9mX-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go2 KUNITZ-TYPE SERINE
PROTEASE INHIBITOR
BBKI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 LEU A 147
VAL A 100
VAL A  45
ILE A  76
 None
 0.70A 5y9mX-2go2A:
undetectable		 5y9mX-2go2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 LEU A 146
VAL A  99
VAL A  44
ILE A  75
 None
 0.67A 5y9mX-2gzbA:
undetectable		 5y9mX-2gzbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		4 LEU A 412
VAL A 543
VAL A 545
ASP A 375
 None
 0.67A 5y9mX-2i7nA:
undetectable		 5y9mX-2i7nA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
MN  A 382 (-2.0A)
 0.41A 5y9mX-2phkA:
25.7		 5y9mX-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 VAL A  46
LYS A  61
ILE A 249
ASP A 250
 ACP  A 999 (-4.6A)
ACP  A 999 (-2.9A)
None
MG  A 401 ( 2.8A)
 0.68A 5y9mX-2punA:
9.2		 5y9mX-2punA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		6 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.57A 5y9mX-2pywA:
9.0		 5y9mX-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzb UNCHARACTERIZED
PROTEIN YFEY

(Escherichia
coli) 		PF06572
(DUF1131) 		4 VAL A  87
LYS A  89
ILE A 114
ASP A 113
 None
 0.60A 5y9mX-2qzbA:
undetectable		 5y9mX-2qzbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reo PUTATIVE
SULFOTRANSFERASE 1C3

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 LEU A 200
VAL A 137
VAL A 135
ILE A  65
 None
 0.66A 5y9mX-2reoA:
undetectable		 5y9mX-2reoA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 VAL A 498
LYS A 511
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.33A 5y9mX-2vuwA:
10.9		 5y9mX-2vuwA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  19
VAL A  27
LYS A  42
ILE A 160
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
 0.63A 5y9mX-2w4kA:
26.8		 5y9mX-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.84A 5y9mX-2w4kA:
26.8		 5y9mX-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Arabidopsis
thaliana) 		PF06090
(Ins_P5_2-kin) 		5 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.61A 5y9mX-2xalA:
3.8		 5y9mX-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 LEU A 205
VAL A 209
ILE A 426
ASP A 434
 None
 0.73A 5y9mX-2xdqA:
undetectable		 5y9mX-2xdqA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A  19
VAL A  27
LYS A  42
ILE A 160
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 (-4.0A)
 0.62A 5y9mX-2yabA:
27.1		 5y9mX-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.72A 5y9mX-2yabA:
27.1		 5y9mX-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 LEU A 105
VAL A 120
VAL A 122
ILE A 176
 None
 0.70A 5y9mX-2ywbA:
undetectable		 5y9mX-2ywbA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 VAL A 264
VAL A 129
LYS A 131
ASP A 305
 None
 0.72A 5y9mX-3actA:
undetectable		 5y9mX-3actA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 4RB  A 401 ( 4.4A)
4RB  A 401 ( 2.8A)
4RB  A 401 (-2.8A)
4RB  A 401 (-3.5A)
GOL  A 503 ( 3.1A)
 0.70A 5y9mX-3bqrA:
23.4		 5y9mX-3bqrA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Saccharomyces
cerevisiae) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 268
VAL A 273
VAL A 275
ILE A 296
 None
 0.66A 5y9mX-3btuA:
undetectable		 5y9mX-3btuA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A1005
VAL A1013
VAL A1026
LYS A1028
ILE A1145
ASP A1146
 ADP  A   1 (-4.1A)
ADP  A   1 ( 4.5A)
ADP  A   1 ( 4.4A)
ADP  A   1 (-3.0A)
ADP  A   1 (-4.0A)
MG  A   8 (-2.3A)
 0.57A 5y9mX-3dlsA:
24.0		 5y9mX-3dlsA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 269
VAL A 274
VAL A 276
ILE A 297
 None
 0.69A 5y9mX-3e1kA:
undetectable		 5y9mX-3e1kA:
11.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL X  54
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 0.69A 5y9mX-3e3bX:
46.7		 5y9mX-3e3bX:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		4 LEU A 169
VAL A 133
VAL A 135
ILE A 189
 None
 0.73A 5y9mX-3enqA:
undetectable		 5y9mX-3enqA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.59A 5y9mX-3f2aA:
24.6		 5y9mX-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6s CLITOCYPIN ANALOG

(Clitocybe
nebularis) 		PF10467
(Inhibitor_I48) 		4 LEU E 130
VAL E  88
VAL E  37
ILE E  64
 None
SME  E  89 ( 3.1A)
None
None
 0.59A 5y9mX-3h6sE:
undetectable		 5y9mX-3h6sE:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 190
VAL A 195
VAL A 174
ASP A 169
 None
 0.65A 5y9mX-3ic9A:
undetectable		 5y9mX-3ic9A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S10,
MITOCHONDRIAL

(Bos taurus) 		PF00338
(Ribosomal_S10) 		4 LEU J 143
VAL J  78
VAL J  80
ILE J 160
 None
 0.73A 5y9mX-3jd5J:
undetectable		 5y9mX-3jd5J:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 118
VAL A  42
VAL A  39
ILE A 207
 None
 0.70A 5y9mX-3k6jA:
undetectable		 5y9mX-3k6jA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
mutans) 		PF01487
(DHquinase_I) 		4 VAL A 174
VAL A 141
LYS A 143
ILE A  58
 None
 0.65A 5y9mX-3l9cA:
undetectable		 5y9mX-3l9cA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  68
VAL A  76
LYS A  91
ASP A 205
 ANP  A 522 (-4.6A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.5A)
MG  A 521 ( 3.6A)
 0.69A 5y9mX-3lijA:
26.8		 5y9mX-3lijA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 VAL A 566
LYS A 581
PHE A 630
ILE A 719
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
 0.39A 5y9mX-3lltA:
26.6		 5y9mX-3lltA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 None
 0.45A 5y9mX-3mi9A:
31.2		 5y9mX-3mi9A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nns DNA BINDING RESPONSE
REGULATOR B

(Thermotoga
maritima) 		PF00072
(Response_reg) 		4 LEU A  49
VAL A  47
VAL A   8
PHE A  31
 None
 0.66A 5y9mX-3nnsA:
undetectable		 5y9mX-3nnsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdw GENTAMICIN
RESISTANCE PROTEIN

(Enterococcus
gallinarum) 		PF01636
(APH) 		4 LEU A  27
VAL A  43
ILE A 217
ASP A 218
 GDP  A 500 (-4.4A)
None
GDP  A 500 ( 4.1A)
MG  A 502 (-1.9A)
 0.33A 5y9mX-3tdwA:
9.4		 5y9mX-3tdwA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  18
LYS A  33
PHE A  79
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 (-4.1A)
NA  A 353 ( 2.5A)
 0.35A 5y9mX-3zduA:
26.8		 5y9mX-3zduA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 VAL A 250
MET A 358
ILE A 368
ASP A 369
 None
 0.65A 5y9mX-4azvA:
9.3		 5y9mX-4azvA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buc UDP-N-ACETYLMURAMOYL
ALANINE--D-GLUTAMATE
LIGASE

(Thermotoga
maritima) 		PF08245
(Mur_ligase_M) 		4 LEU A  63
VAL A  68
VAL A  49
PHE A  25
 None
 0.70A 5y9mX-4bucA:
undetectable		 5y9mX-4bucA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		4 VAL B 158
LYS B 160
ILE B 285
ASP B 286
 None
 0.64A 5y9mX-4ci6B:
12.0		 5y9mX-4ci6B:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8b RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Escherichia
coli) 		PF04452
(Methyltrans_RNA) 		4 LEU A 167
VAL A 189
VAL A 186
ILE A 179
 None
 0.69A 5y9mX-4e8bA:
undetectable		 5y9mX-4e8bA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 LEU A  67
VAL A  91
VAL A  89
ILE A 183
 None
 0.68A 5y9mX-4f2aA:
undetectable		 5y9mX-4f2aA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		4 LEU A 194
VAL A 199
VAL A 223
PHE A 230
 None
 0.72A 5y9mX-4gz2A:
undetectable		 5y9mX-4gz2A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 406
VAL A 414
LYS A 429
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
T28  A 701 ( 3.4A)
 0.56A 5y9mX-4idtA:
22.3		 5y9mX-4idtA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix3 MSSTT7D PROTEIN

(Micromonas
commoda) 		PF00069
(Pkinase) 		4 VAL A 186
VAL A 198
ILE A 337
ASP A 338
 None
None
None
MG  A 601 (-2.6A)
 0.48A 5y9mX-4ix3A:
4.1		 5y9mX-4ix3A:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		5 VAL A  63
LYS A  80
MET A 203
ILE A 211
ASP A 212
 1L7  A 301 ( 4.8A)
1L7  A 301 (-2.8A)
1L7  A 301 ( 4.3A)
1L7  A 301 (-4.4A)
1L7  A 301 (-3.6A)
 0.78A 5y9mX-4jinA:
10.9		 5y9mX-4jinA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  54
VAL A  67
LYS A  69
MET A 202
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
GNP  A 401 (-3.6A)
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.62A 5y9mX-4jr7A:
45.1		 5y9mX-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  54
VAL A  67
LYS A  69
PHE A 152
ILE A 213
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-4.8A)
GNP  A 401 (-3.3A)
None
GNP  A 401 (-4.6A)
GNP  A 401 ( 2.7A)
 0.29A 5y9mX-4jr7A:
45.1		 5y9mX-4jr7A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrj EFFECTOR NLEH1

(Escherichia
coli) 		no annotation 4 VAL A 147
VAL A 157
LYS A 159
ILE A 257
 ANP  A 301 (-4.2A)
ANP  A 301 (-4.9A)
ANP  A 301 (-3.6A)
ANP  A 301 (-4.2A)
 0.39A 5y9mX-4lrjA:
9.2		 5y9mX-4lrjA:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL E  53
VAL E  66
LYS E  68
PHE E 113
MET E 163
ILE E 174
ASP E 175
 None
 0.48A 5y9mX-4md8E:
42.5		 5y9mX-4md8E:
77.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  86
LYS A 101
ILE A 212
ASP A 213
 STU  A 601 (-4.8A)
STU  A 601 (-3.9A)
STU  A 601 (-4.3A)
STU  A 601 (-4.3A)
 0.51A 5y9mX-4mvfA:
21.2		 5y9mX-4mvfA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o96 TYPE III EFFECTOR
PROTEIN KINASE

(Escherichia
coli) 		no annotation 5 VAL A 157
VAL A 167
LYS A 169
ILE A 267
ASP A 268
 GOL  A 401 ( 4.9A)
GOL  A 401 (-4.7A)
None
GOL  A 401 (-4.6A)
None
 0.92A 5y9mX-4o96A:
8.5		 5y9mX-4o96A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 801
VAL A 819
LYS A 821
ILE A 945
ASP A 946
 ADP  A1501 (-3.8A)
None
ADP  A1501 (-2.7A)
ADP  A1501 ( 3.9A)
MG  A1503 (-1.7A)
 0.46A 5y9mX-4qpmA:
18.3		 5y9mX-4qpmA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  24
VAL A  32
LYS A  47
ASP A 159
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.7A)
 0.66A 5y9mX-4rewA:
24.4		 5y9mX-4rewA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32

(Saccharomyces
cerevisiae) 		PF06293
(Kdo) 		4 VAL A  30
LYS A  52
ILE A 181
ASP A 182
 AMP  A 301 (-4.4A)
AMP  A 301 (-2.8A)
AMP  A 301 ( 4.3A)
AMP  A 301 (-3.4A)
 0.43A 5y9mX-4ww7A:
6.5		 5y9mX-4ww7A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x84 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Pseudomonas
aeruginosa) 		PF06026
(Rib_5-P_isom_A) 		4 LEU A 173
VAL A 137
VAL A 139
ILE A 193
 None
 0.73A 5y9mX-4x84A:
undetectable		 5y9mX-4x84A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 LEU A 361
VAL A 366
VAL A 340
PHE A 241
 None
 0.69A 5y9mX-4xwtA:
undetectable		 5y9mX-4xwtA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0x SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16919
(PknG_rubred) 		4 VAL A 179
LYS A 181
ILE A 292
ASP A 293
 ADP  A 501 (-4.7A)
ADP  A 501 (-2.7A)
ADP  A 501 ( 4.2A)
MG  A 504 (-2.3A)
 0.66A 5y9mX-4y0xA:
14.8		 5y9mX-4y0xA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 173
LYS A 188
PHE A 238
ASP A 307
 4E1  A 505 (-4.5A)
4E1  A 505 (-2.7A)
4E1  A 505 (-4.2A)
4E1  A 505 (-3.6A)
 0.28A 5y9mX-4yljA:
28.1		 5y9mX-4yljA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  42
LYS A  57
ILE A 171
ASP A 172
 ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
ADP  A 506 (-4.5A)
ADP  A 506 ( 2.4A)
 0.46A 5y9mX-4ysjA:
27.1		 5y9mX-4ysjA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvh PCPI-3

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		4 LEU A 178
VAL A 115
VAL A  46
ILE A  80
 None
 0.70A 5y9mX-5dvhA:
undetectable		 5y9mX-5dvhA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzu ASPARTIC PROTEASE
INHIBITOR 11

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		4 LEU A 173
VAL A  52
VAL A  36
ILE A  83
 None
 0.73A 5y9mX-5dzuA:
undetectable		 5y9mX-5dzuA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e26 PANTOTHENATE KINASE
2, MITOCHONDRIAL

(Homo sapiens) 		PF03630
(Fumble) 		4 LEU A 387
VAL A 518
VAL A 520
ASP A 350
 None
 0.69A 5y9mX-5e26A:
undetectable		 5y9mX-5e26A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 LEU A 145
VAL A 244
VAL A 242
ASP A 343
 None
None
None
BGC  A 918 ( 3.8A)
 0.71A 5y9mX-5ej1A:
undetectable		 5y9mX-5ej1A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 VAL A  28
LYS A  43
PHE A  90
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
MG  A 302 ( 3.3A)
 0.32A 5y9mX-5hu3A:
27.1		 5y9mX-5hu3A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i47 RIMK DOMAIN PROTEIN
ATP-GRASP

(Sphaerobacter
thermophilus) 		PF08443
(RimK) 		4 LEU A 180
VAL A 234
VAL A 236
ILE A 101
 None
 0.71A 5y9mX-5i47A:
undetectable		 5y9mX-5i47A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 163
LYS A 178
PHE A 228
ILE A 294
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 (-4.2A)
7A7  A 501 (-3.2A)
 0.46A 5y9mX-5lxdA:
27.6		 5y9mX-5lxdA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  45
VAL A  53
VAL A  66
LYS A  68
ASP A 175
 HC4  A 401 ( 4.8A)
None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-4.0A)
 0.74A 5y9mX-5movA:
48.4		 5y9mX-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  53
VAL A  66
LYS A  68
MET A 163
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 ( 4.0A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.67A 5y9mX-5movA:
48.4		 5y9mX-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  53
VAL A  66
LYS A  68
PHE A 113
ILE A 174
ASP A 175
 None
HC4  A 401 (-4.4A)
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
HC4  A 401 ( 3.7A)
HC4  A 401 (-4.0A)
 0.25A 5y9mX-5movA:
48.4		 5y9mX-5movA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oet GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 30
(GPA-GSS30-APO)

(Globodera
pallida) 		no annotation 4 LEU B 300
VAL B 308
VAL B 311
ILE B 282
 None
 0.70A 5y9mX-5oetB:
undetectable		 5y9mX-5oetB:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 4 VAL A  52
LYS A  67
ILE A 185
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 ( 4.3A)
None
 0.37A 5y9mX-5turA:
24.4		 5y9mX-5turA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 4 VAL A  25
LYS A  40
ILE A 149
ASP A 150
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.6A)
7LV  A 401 (-4.2A)
 0.59A 5y9mX-5tvtA:
22.8		 5y9mX-5tvtA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A  25
LYS A  40
MET A 145
ASP A 156
 G93  A 301 (-3.4A)
G93  A 301 (-3.0A)
G93  A 301 ( 3.7A)
G93  A 301 ( 3.2A)
 0.54A 5y9mX-5u94A:
25.0		 5y9mX-5u94A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		PF03770
(IPK) 		4 VAL A  73
LYS A  75
ILE A 274
ASP A 275
 None
ADP  A 503 (-2.7A)
ADP  A 503 ( 4.3A)
MG  A 502 (-2.2A)
 0.47A 5y9mX-5w2hA:
6.9		 5y9mX-5w2hA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxm U3 SMALL NUCLEOLAR
RIBONUCLEOPROTEIN
PROTEIN IMP3

(Saccharomyces
cerevisiae) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		4 LEU A  82
VAL A  87
VAL A 101
ILE A  50
 None
 0.70A 5y9mX-5wxmA:
undetectable		 5y9mX-5wxmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 115
VAL A   9
VAL A   7
ILE A  20
 None
 0.64A 5y9mX-5wyrA:
undetectable		 5y9mX-5wyrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvu CASEIN KINASE 2,
ALPHA SUBUNIT

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 VAL A  57
LYS A  72
PHE A 117
ILE A 178
 ATP  A 403 (-3.9A)
ATP  A 403 (-3.2A)
None
ATP  A 403 ( 4.5A)
 0.25A 5y9mX-5xvuA:
45.9		 5y9mX-5xvuA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 VAL A 223
LYS A 238
PHE A 288
ILE A 354
ASP A 355
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.3A)
HRM  A 601 (-3.6A)
HRM  A 601 (-3.7A)
HRM  A 601 (-4.7A)
 0.31A 5y9mX-5y86A:
22.0		 5y9mX-5y86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 4 LEU B 235
VAL B 205
VAL B 203
MET B  95
 None
 0.70A 5y9mX-5yewB:
undetectable		 5y9mX-5yewB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys6 PRV GLYCOPROTEN B

(Suid
alphaherpesvirus
1) 		no annotation 4 LEU A 414
VAL A 454
VAL A 462
PHE A 161
 None
 0.51A 5y9mX-5ys6A:
undetectable		 5y9mX-5ys6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysq TM0415

(Thermotoga
maritima) 		no annotation 4 LEU A  58
VAL A  63
VAL A  43
PHE A   4
 None
 0.70A 5y9mX-5ysqA:
undetectable		 5y9mX-5ysqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 4 VAL A 142
LYS A 157
PHE A 230
ASP A 293
 H1N  A 501 (-4.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-3.7A)
H1N  A 501 (-3.5A)
 0.51A 5y9mX-6ccfA:
24.3		 5y9mX-6ccfA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 4 LEU A 169
VAL A 177
LYS A 193
PHE A 243
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
3NG  A 501 (-3.5A)
 0.71A 5y9mX-6fylA:
27.7		 5y9mX-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 4 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 None
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-4.6A)
 0.35A 5y9mX-6fyoA:
22.3		 5y9mX-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 LEU A 167
VAL A 175
LYS A 191
PHE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-3.5A)
 0.66A 5y9mX-6fyvA:
28.2		 5y9mX-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 4 VAL A 175
LYS A 191
PHE A 241
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
3NG  A 501 (-3.5A)
3NG  A 501 (-4.3A)
 0.46A 5y9mX-6fyvA:
28.2		 5y9mX-6fyvA:
undetectable