SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y9M_A_NIOA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9n U2A'

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A 115
VAL A 142
VAL A 139
ILE A 120
ASP A 146
 None
 1.35A 5y9mA-1a9nA:
undetectable		 5y9mA-1a9nA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		4 LEU A 106
VAL A 144
VAL A 142
ILE A 162
 None
 0.65A 5y9mA-1bp1A:
undetectable		 5y9mA-1bp1A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		4 VAL A  14
VAL A  76
PHE A 113
ILE A 125
 None
 0.79A 5y9mA-1cvrA:
undetectable		 5y9mA-1cvrA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE

(Nicotiana
tabacum) 		PF01053
(Cys_Met_Meta_PP) 		4 VAL A 217
VAL A 222
ILE A 184
ASP A 185
 None
 0.73A 5y9mA-1i41A:
undetectable		 5y9mA-1i41A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 LEU A 202
VAL A 205
VAL A 207
ILE A   6
 None
 0.75A 5y9mA-1i8tA:
undetectable		 5y9mA-1i8tA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfd INORGANIC
PYROPHOSPHATASE

(Escherichia
coli) 		PF00719
(Pyrophosphatase) 		4 LEU A 105
VAL A  71
VAL A  69
ILE A  15
 None
 0.79A 5y9mA-1jfdA:
undetectable		 5y9mA-1jfdA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		4 VAL A  31
LYS A  44
ILE A 207
ASP A 208
 ADP  A 300 ( 4.8A)
ADP  A 300 (-2.7A)
ADP  A 300 (-4.1A)
MG  A 302 (-2.1A)
 0.65A 5y9mA-1l8tA:
8.3		 5y9mA-1l8tA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1leh LEUCINE
DEHYDROGENASE

(Lysinibacillus
sphaericus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 192
MET A 158
ILE A 233
ASP A 232
 None
 0.79A 5y9mA-1lehA:
undetectable		 5y9mA-1lehA:
13.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		6 VAL A  53
LYS A  68
PHE A 113
MET A 163
ILE A 174
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
HNA  A 351 (-3.6A)
HNA  A 351 ( 3.8A)
HNA  A 351 (-3.8A)
HNA  A 351 (-3.3A)
 0.72A 5y9mA-1m2pA:
47.8		 5y9mA-1m2pA:
70.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 LEU A 253
VAL A 249
VAL A 228
ILE A 263
ASP A 265
 None
 1.46A 5y9mA-1pjbA:
undetectable		 5y9mA-1pjbA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		4 VAL A 173
MET A  51
ILE A 275
ASP A 274
 None
None
None
EDO  A 313 (-3.1A)
 0.76A 5y9mA-1pyfA:
undetectable		 5y9mA-1pyfA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 VAL A 172
LYS A 187
PHE A 246
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
ADP  A 810 ( 3.0A)
 0.38A 5y9mA-1q8yA:
19.1		 5y9mA-1q8yA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 624
LYS A 644
PHE A 691
 None
 0.71A 5y9mA-1rjbA:
20.1		 5y9mA-1rjbA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tie ERYTHRINA TRYPSIN
INHIBITOR

(Erythrina
caffra) 		PF00197
(Kunitz_legume) 		4 LEU A 154
VAL A  43
VAL A  29
ILE A  75
 None
 0.73A 5y9mA-1tieA:
undetectable		 5y9mA-1tieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tie ERYTHRINA TRYPSIN
INHIBITOR

(Erythrina
caffra) 		PF00197
(Kunitz_legume) 		4 LEU A 154
VAL A 101
VAL A  43
ILE A  75
 None
 0.67A 5y9mA-1tieA:
undetectable		 5y9mA-1tieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl0 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE, RFBD
ORTHOLOG

(Clostridium
acetobutylicum) 		PF04321
(RmlD_sub_bind) 		4 LEU A 172
VAL A 231
VAL A 229
ILE A 221
 None
 0.61A 5y9mA-1vl0A:
undetectable		 5y9mA-1vl0A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfj DNA ADENINE
METHYLASE

(Escherichia
virus T4) 		PF02086
(MethyltransfD12) 		4 LEU A  31
VAL A 170
VAL A 168
PHE A 207
 None
 0.77A 5y9mA-1yfjA:
undetectable		 5y9mA-1yfjA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zao RIO2 SERINE KINASE

(Archaeoglobus
fulgidus) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 VAL A 106
VAL A 118
LYS A 120
ILE A 234
ASP A 235
 ATP  A 286 (-4.6A)
ATP  A 286 (-4.9A)
ATP  A 286 (-2.6A)
ATP  A 286 (-4.5A)
ATP  A 286 ( 2.5A)
 0.49A 5y9mA-1zaoA:
9.8		 5y9mA-1zaoA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 376
VAL A 299
VAL A 296
ILE A 465
 None
 0.77A 5y9mA-1zcjA:
undetectable		 5y9mA-1zcjA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zej 3-HYDROXYACYL-COA
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 148
VAL A 128
MET A  66
ILE A  15
 None
 0.67A 5y9mA-1zejA:
undetectable		 5y9mA-1zejA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
LYS A  38
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
HYM  A 400 (-3.9A)
 0.80A 5y9mA-1zltA:
7.2		 5y9mA-1zltA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  27
LYS A  42
ILE A 160
ASP A 161
 None
 0.75A 5y9mA-1zwsA:
27.3		 5y9mA-1zwsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyl HYPOTHETICAL PROTEIN
YIHE

(Escherichia
coli) 		PF01636
(APH) 		4 VAL A  41
VAL A  53
PHE A 106
ASP A 217
 None
 0.67A 5y9mA-1zylA:
6.9		 5y9mA-1zylA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 281
VAL B 294
LYS B 296
ASP B 432
 None
 0.39A 5y9mA-2a1aB:
21.8		 5y9mA-2a1aB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
ILE A 160
ASP A 161
 None
None
None
GOL  A3001 ( 3.9A)
None
 0.56A 5y9mA-2a2aA:
17.7		 5y9mA-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 None
None
GOL  A3001 (-4.4A)
GOL  A3001 ( 3.9A)
None
 1.05A 5y9mA-2a2aA:
17.7		 5y9mA-2a2aA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
VAL X  25
LYS X  39
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.6A)
 0.62A 5y9mA-2dq7X:
23.5		 5y9mA-2dq7X:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF14681
(UPRTase) 		4 VAL A 125
VAL A 155
LYS A 153
PHE A 177
 None
 0.47A 5y9mA-2e55A:
undetectable		 5y9mA-2e55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekd HYPOTHETICAL PROTEIN
PH0250

(Pyrococcus
horikoshii) 		PF03192
(DUF257) 		4 LEU A 177
VAL A  18
VAL A  16
ILE A  33
 None
 0.76A 5y9mA-2ekdA:
undetectable		 5y9mA-2ekdA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
VAL A 170
LYS A 186
PHE A 236
ASP A 320
 None
 0.60A 5y9mA-2eu9A:
27.5		 5y9mA-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exa PENICILLIN-BINDING
PROTEIN 4

(Escherichia
coli) 		PF02113
(Peptidase_S13) 		4 LEU A 405
VAL A 410
VAL A 414
ILE A 473
 None
 0.80A 5y9mA-2exaA:
undetectable		 5y9mA-2exaA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go2 KUNITZ-TYPE SERINE
PROTEASE INHIBITOR
BBKI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 LEU A 147
VAL A 100
VAL A  45
ILE A  76
 None
 0.69A 5y9mA-2go2A:
undetectable		 5y9mA-2go2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzb KUNITZ-TYPE
PROTEINASE INHIBITOR
BBCI

(Bauhinia
bauhinioides) 		PF00197
(Kunitz_legume) 		4 LEU A 146
VAL A  99
VAL A  44
ILE A  75
 None
 0.67A 5y9mA-2gzbA:
undetectable		 5y9mA-2gzbA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  55
VAL A  63
LYS A  78
PHE A 124
 None
 0.77A 5y9mA-2hw6A:
20.5		 5y9mA-2hw6A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7n PANTOTHENATE KINASE
1

(Homo sapiens) 		PF03630
(Fumble) 		4 LEU A 412
VAL A 543
VAL A 545
ASP A 375
 None
 0.61A 5y9mA-2i7nA:
undetectable		 5y9mA-2i7nA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
MN  A 382 (-2.0A)
 0.42A 5y9mA-2phkA:
25.6		 5y9mA-2phkA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkh HISTIDINE
UTILIZATION
REPRESSOR

(Pseudomonas
syringae group
genomosp. 3) 		PF07702
(UTRA) 		4 LEU A 181
VAL A 159
PHE A 139
ASP A 166
 None
 0.73A 5y9mA-2pkhA:
undetectable		 5y9mA-2pkhA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pun METHYLTHIORIBOSE
KINASE

(Bacillus
subtilis) 		PF01636
(APH) 		4 VAL A  46
LYS A  61
ILE A 249
ASP A 250
 ACP  A 999 (-4.6A)
ACP  A 999 (-2.9A)
None
MG  A 401 ( 2.8A)
 0.73A 5y9mA-2punA:
9.0		 5y9mA-2punA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN

(Arabidopsis
thaliana) 		PF01636
(APH) 		6 VAL A  50
VAL A  61
LYS A  63
MET A 245
ILE A 254
ASP A 255
 ADP  A 999 (-4.3A)
ADP  A 999 (-4.6A)
ADP  A 999 (-2.7A)
ADP  A 999 (-3.5A)
ADP  A 999 ( 4.3A)
MG  A 500 (-1.8A)
 0.56A 5y9mA-2pywA:
8.8		 5y9mA-2pywA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzb UNCHARACTERIZED
PROTEIN YFEY

(Escherichia
coli) 		PF06572
(DUF1131) 		4 VAL A  87
LYS A  89
ILE A 114
ASP A 113
 None
 0.58A 5y9mA-2qzbA:
undetectable		 5y9mA-2qzbA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reo PUTATIVE
SULFOTRANSFERASE 1C3

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 LEU A 200
VAL A 137
VAL A 135
ILE A  65
 None
 0.65A 5y9mA-2reoA:
undetectable		 5y9mA-2reoA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		4 LEU A 422
VAL A 325
VAL A 314
ILE A 351
 None
 0.79A 5y9mA-2vsaA:
undetectable		 5y9mA-2vsaA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		5 VAL A 498
LYS A 511
PHE A 605
ILE A 686
ASP A 687
 5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
IOD  A1799 (-4.2A)
IOD  A1799 (-4.0A)
 0.37A 5y9mA-2vuwA:
15.4		 5y9mA-2vuwA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
ILE A 160
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.69A 5y9mA-2w4kA:
26.7		 5y9mA-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 (-4.2A)
ADP  A1303 ( 4.1A)
MG  A1304 ( 2.8A)
 0.83A 5y9mA-2w4kA:
26.7		 5y9mA-2w4kA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 376
VAL A 299
VAL A 296
ILE A 465
 None
 0.78A 5y9mA-2x58A:
undetectable		 5y9mA-2x58A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xal INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Arabidopsis
thaliana) 		PF06090
(Ins_P5_2-kin) 		5 VAL A  24
VAL A  38
MET A 372
ILE A 406
ASP A 407
 ADP  A 600 (-4.2A)
ADP  A 600 ( 4.9A)
ADP  A 600 (-3.5A)
ADP  A 600 ( 3.8A)
ADP  A 600 ( 2.1A)
 0.58A 5y9mA-2xalA:
2.9		 5y9mA-2xalA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xb3 PSBP PROTEIN

(Thermosynechococcus
elongatus) 		PF01789
(PsbP) 		5 LEU A 157
VAL A  69
VAL A  67
PHE A  57
ASP A  31
 None
None
None
None
ZN  A1001 (-2.2A)
 1.04A 5y9mA-2xb3A:
undetectable		 5y9mA-2xb3A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		4 LEU A 205
VAL A 209
ILE A 426
ASP A 434
 None
 0.70A 5y9mA-2xdqA:
undetectable		 5y9mA-2xdqA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtl CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 VAL A 230
VAL A 197
LYS A 199
ASP A 247
 None
 0.77A 5y9mA-2xtlA:
undetectable		 5y9mA-2xtlA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  19
VAL A  27
LYS A  42
ILE A 160
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.65A 5y9mA-2yabA:
27.1		 5y9mA-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
AMP  A1302 ( 4.0A)
AMP  A1302 (-4.0A)
AMP  A1302 (-3.1A)
 0.71A 5y9mA-2yabA:
27.1		 5y9mA-2yabA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 LEU A 105
VAL A 120
VAL A 122
ILE A 176
 None
 0.71A 5y9mA-2ywbA:
undetectable		 5y9mA-2ywbA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 LEU A 229
VAL A 234
VAL A 212
PHE A 311
 None
 0.72A 5y9mA-2ywbA:
undetectable		 5y9mA-2ywbA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  68
VAL A  76
LYS A  94
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-2.8A)
STU  A   1 ( 3.8A)
 0.76A 5y9mA-2z7rA:
21.9		 5y9mA-2z7rA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 VAL A 264
VAL A 129
LYS A 131
ASP A 305
 None
 0.77A 5y9mA-3actA:
undetectable		 5y9mA-3actA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5n PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9
SYNAPTOBREVIN
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00804
(Syntaxin)
PF00957
(Synaptobrevin)
PF05739
(SNARE)
no annotation 		4 LEU C 479
VAL C 475
VAL B 235
ILE A  60
 None
 0.78A 5y9mA-3b5nC:
undetectable		 5y9mA-3b5nC:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  27
LYS A  42
MET A 146
ILE A 160
ASP A 161
 4RB  A 401 ( 4.4A)
4RB  A 401 ( 2.8A)
4RB  A 401 (-2.8A)
4RB  A 401 (-3.5A)
GOL  A 503 ( 3.1A)
 0.70A 5y9mA-3bqrA:
23.3		 5y9mA-3bqrA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btu GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Saccharomyces
cerevisiae) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 268
VAL A 273
VAL A 275
ILE A 296
 None
 0.67A 5y9mA-3btuA:
undetectable		 5y9mA-3btuA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbg PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 LEU A 272
VAL A 268
MET A 176
ILE A 230
 None
 0.75A 5y9mA-3dbgA:
undetectable		 5y9mA-3dbgA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dls PAS
DOMAIN-CONTAINING
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A1005
VAL A1013
VAL A1026
LYS A1028
ILE A1145
ASP A1146
 ADP  A   1 (-4.1A)
ADP  A   1 ( 4.5A)
ADP  A   1 ( 4.4A)
ADP  A   1 (-3.0A)
ADP  A   1 (-4.0A)
MG  A   8 (-2.3A)
 0.60A 5y9mA-3dlsA:
24.2		 5y9mA-3dlsA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1k GALACTOSE/LACTOSE
METABOLISM
REGULATORY PROTEIN
GAL80

(Kluyveromyces
lactis) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 269
VAL A 274
VAL A 276
ILE A 297
 None
 0.74A 5y9mA-3e1kA:
undetectable		 5y9mA-3e1kA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A 109
VAL A 205
VAL A 203
ASP A 224
 None
 0.79A 5y9mA-3e3aA:
undetectable		 5y9mA-3e3aA:
16.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU X  46
VAL X  54
VAL X  67
LYS X  69
PHE X 114
ILE X 175
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
 1.01A 5y9mA-3e3bX:
36.1		 5y9mA-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU X  46
VAL X  54
VAL X  67
PHE X 114
ILE X 175
ASP X 176
 CCK  X 351 (-4.0A)
CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.07A 5y9mA-3e3bX:
36.1		 5y9mA-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL X  54
VAL X  67
LYS X  69
PHE X 114
MET X 164
ILE X 175
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
 1.03A 5y9mA-3e3bX:
36.1		 5y9mA-3e3bX:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL X  54
VAL X  67
PHE X 114
MET X 164
ILE X 175
ASP X 176
 CCK  X 351 ( 4.3A)
CCK  X 351 ( 4.3A)
CCK  X 351 (-3.8A)
CCK  X 351 (-3.5A)
CCK  X 351 (-3.9A)
CCK  X 351 (-4.1A)
 1.09A 5y9mA-3e3bX:
36.1		 5y9mA-3e3bX:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		4 LEU A 169
VAL A 133
VAL A 135
ILE A 189
 None
 0.78A 5y9mA-3enqA:
undetectable		 5y9mA-3enqA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  44
VAL A  52
LYS A  67
ILE A 185
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-3.7A)
985  A   1 ( 4.0A)
 0.59A 5y9mA-3f2aA:
18.5		 5y9mA-3f2aA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f65 CHAPERONE PROTEIN
FAEE

(Escherichia
coli) 		PF00345
(PapD_N) 		4 LEU A 152
VAL A 185
VAL A 181
ILE A 127
 None
 0.71A 5y9mA-3f65A:
undetectable		 5y9mA-3f65A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3

(Campylobacter
jejuni) 		PF13531
(SBP_bac_11) 		5 LEU A  24
VAL A  51
VAL A  49
ILE A  37
ASP A  36
 None
 0.96A 5y9mA-3fj7A:
undetectable		 5y9mA-3fj7A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkc TRANSCRIPTIONAL
REGULATOR KAISO

(Homo sapiens) 		PF00651
(BTB) 		4 LEU A  70
VAL A  38
VAL A  36
ILE A  81
 None
 0.80A 5y9mA-3fkcA:
undetectable		 5y9mA-3fkcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		4 LEU A 207
VAL A 234
VAL A 230
ILE A 192
 None
 0.80A 5y9mA-3gczA:
undetectable		 5y9mA-3gczA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk6 INTEGRON CASSETTE
PROTEIN VCH_CASS2

(Vibrio cholerae) 		PF14526
(Cass2) 		5 LEU A  34
VAL A  16
VAL A  69
PHE A  67
ASP A  22
 None
 1.47A 5y9mA-3gk6A:
undetectable		 5y9mA-3gk6A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6s CLITOCYPIN ANALOG

(Clitocybe
nebularis) 		PF10467
(Inhibitor_I48) 		4 LEU E 130
VAL E  88
VAL E  37
ILE E  64
 None
SME  E  89 ( 3.1A)
None
None
 0.60A 5y9mA-3h6sE:
undetectable		 5y9mA-3h6sE:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  82
VAL A  90
LYS A 105
ASP A 220
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
J60  A 540 ( 3.6A)
 0.75A 5y9mA-3hztA:
20.1		 5y9mA-3hztA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3l ALKYLHALIDASE CMLS

(Streptomyces
venezuelae) 		PF04820
(Trp_halogenase) 		4 LEU A  46
VAL A 103
VAL A 105
ILE A  63
 None
 0.74A 5y9mA-3i3lA:
undetectable		 5y9mA-3i3lA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic9 DIHYDROLIPOAMIDE
DEHYDROGENASE

(Colwellia
psychrerythraea) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 190
VAL A 195
VAL A 174
ASP A 169
 None
 0.64A 5y9mA-3ic9A:
undetectable		 5y9mA-3ic9A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  90
LYS A 105
ILE A 218
ASP A 219
 ANP  A 610 (-3.9A)
ANP  A 610 (-2.8A)
ANP  A 610 ( 4.4A)
ANP  A 610 ( 2.7A)
 0.70A 5y9mA-3igoA:
20.3		 5y9mA-3igoA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 LEU A 141
VAL A 149
VAL A 162
LYS A 164
ILE A 280
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
ANP  A   1 (-4.4A)
GOL  A 398 ( 3.1A)
ANP  A   1 (-4.2A)
 0.87A 5y9mA-3is5A:
17.4		 5y9mA-3is5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv4 PUTATIVE
OXIDOREDUCTASE

(Staphylococcus
aureus) 		PF11009
(DUF2847) 		4 LEU A   5
VAL A  23
LYS A  25
PHE A  80
 None
 0.76A 5y9mA-3iv4A:
undetectable		 5y9mA-3iv4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S10,
MITOCHONDRIAL

(Bos taurus) 		PF00338
(Ribosomal_S10) 		4 LEU J 143
VAL J  78
VAL J  80
ILE J 160
 None
 0.66A 5y9mA-3jd5J:
undetectable		 5y9mA-3jd5J:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k5h PHOSPHORIBOSYL-AMINO
IMIDAZOLE
CARBOXYLASE

(Aspergillus
clavatus) 		PF01262
(AlaDh_PNT_C)
PF02222
(ATP-grasp) 		4 VAL A 201
VAL A 194
LYS A 196
PHE A 251
 None
 0.74A 5y9mA-3k5hA:
undetectable		 5y9mA-3k5hA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6j PROTEIN F01G10.3,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 118
VAL A  42
VAL A  39
ILE A 207
 None
 0.75A 5y9mA-3k6jA:
undetectable		 5y9mA-3k6jA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 432
LYS A 455
ILE A 564
ASP A 565
 ANP  A 400 (-4.1A)
None
ANP  A 400 (-3.9A)
None
 0.73A 5y9mA-3kn5A:
20.4		 5y9mA-3kn5A:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE

(Streptococcus
mutans) 		PF01487
(DHquinase_I) 		4 VAL A 174
VAL A 141
LYS A 143
ILE A  58
 None
 0.68A 5y9mA-3l9cA:
undetectable		 5y9mA-3l9cA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  68
VAL A  76
LYS A  91
ASP A 205
 ANP  A 522 (-4.6A)
ANP  A 522 (-4.1A)
ANP  A 522 (-3.5A)
MG  A 521 ( 3.6A)
 0.71A 5y9mA-3lijA:
26.7		 5y9mA-3lijA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 VAL A 566
LYS A 581
PHE A 630
ILE A 719
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
ANP  A 877 (-2.9A)
 0.77A 5y9mA-3lltA:
26.7		 5y9mA-3lltA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR

(Rhodopseudomonas
palustris) 		PF01042
(Ribonuc_L-PSP) 		5 VAL A 134
VAL A 106
PHE A 105
MET A  81
ILE A 148
 SO4  A  15 (-3.8A)
None
None
None
None
 1.30A 5y9mA-3lmeA:
undetectable		 5y9mA-3lmeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  33
LYS A  48
PHE A 103
ASP A 167
 None
 0.48A 5y9mA-3mi9A:
31.2		 5y9mA-3mi9A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n8u IMELYSIN PEPTIDASE

(Bacteroides
ovatus) 		PF09375
(Peptidase_M75) 		4 LEU A 249
VAL A 252
VAL A  98
ILE A 176
 None
 0.78A 5y9mA-3n8uA:
undetectable		 5y9mA-3n8uA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  37
LYS A  51
PHE A  98
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-2.8A)
None
MG  A 312 ( 3.3A)
 0.61A 5y9mA-3nizA:
28.9		 5y9mA-3nizA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nns DNA BINDING RESPONSE
REGULATOR B

(Thermotoga
maritima) 		PF00072
(Response_reg) 		4 LEU A  49
VAL A  47
VAL A   8
PHE A  31
 None
 0.72A 5y9mA-3nnsA:
undetectable		 5y9mA-3nnsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		4 LEU A  29
VAL A   6
VAL A   4
PHE A 232
 None
AMP  A 422 ( 4.7A)
None
None
 0.79A 5y9mA-3nrnA:
undetectable		 5y9mA-3nrnA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oy2 GLYCOSYLTRANSFERASE
B736L

(Paramecium
bursaria
Chlorella virus
NY2A) 		no annotation 4 LEU A 300
VAL A 317
VAL A 366
PHE A 369
 None
 0.77A 5y9mA-3oy2A:
undetectable		 5y9mA-3oy2A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  63
VAL A  71
LYS A  86
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.1A)
MG  A 529 (-2.2A)
 0.63A 5y9mA-3q5iA:
24.6		 5y9mA-3q5iA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsy TRANSLATION
INITIATION FACTOR 2
SUBUNIT ALPHA

(Sulfolobus
solfataricus) 		PF07541
(EIF_2_alpha) 		4 LEU B 250
VAL B 259
VAL B 185
ILE B 196
 None
 0.76A 5y9mA-3qsyB:
undetectable		 5y9mA-3qsyB:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 LEU A 191
VAL A 128
VAL A 126
ILE A  57
 None
 0.75A 5y9mA-3qvuA:
undetectable		 5y9mA-3qvuA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4r HYPOTHETICAL
FIMBRIAL ASSEMBLY
PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		5 LEU A 219
VAL A 216
VAL A 263
PHE A 278
ILE A 194
 None
 1.40A 5y9mA-3r4rA:
undetectable		 5y9mA-3r4rA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc2 KUNITZ-TYPE
PROTEINASE INHIBITOR
P1H5

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		4 LEU A 171
VAL A  52
VAL A  36
ILE A  87
 None
 0.72A 5y9mA-3tc2A:
undetectable		 5y9mA-3tc2A:
16.58