SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y9A_A_AR3A201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 ALA A 266
LYS A 109
GLN A 243
ASP A 239
 None
 1.44A 5y9aA-1jr1A:
undetectable		 5y9aA-1jr1A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn9 GLUTATHIONE
S-TRANSFERASE 1-6

(Anopheles
gambiae) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ALA A 160
LYS A 187
GLN A 197
ASP A 201
 None
 1.49A 5y9aA-1pn9A:
undetectable		 5y9aA-1pn9A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxr PEPTIDOGLYCAN
RECOGNITION PROTEIN
SA CG11709-PA

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		4 ALA A  55
GLN A  59
TRP A  20
GLN A  62
 None
 1.31A 5y9aA-1sxrA:
undetectable		 5y9aA-1sxrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vls ASPARTATE RECEPTOR

(Salmonella
enterica) 		PF02203
(TarH) 		4 ALA A 101
GLN A 131
GLN A 128
ASP A 124
 None
 1.38A 5y9aA-1vlsA:
undetectable		 5y9aA-1vlsA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7s PROBABLE
PROPIONYL-COA
CARBOXYLASE BETA
CHAIN 5

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 ALA A 331
GLN A 335
GLN A 355
ASP A 313
 None
 1.30A 5y9aA-2a7sA:
2.3		 5y9aA-2a7sA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		4 ALA A 484
GLN A 483
GLN A 893
ASP A 476
 None
 1.22A 5y9aA-2hg4A:
2.6		 5y9aA-2hg4A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ALA A 587
LYS A 375
GLN A 349
ASP A 353
 None
 1.48A 5y9aA-2hnhA:
undetectable		 5y9aA-2hnhA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 ALA A  25
LYS A 261
GLN A 257
ASP A 253
 None
 1.41A 5y9aA-2isqA:
1.6		 5y9aA-2isqA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lig ASPARTATE RECEPTOR

(Salmonella
enterica) 		PF02203
(TarH) 		4 ALA A 101
GLN A 131
GLN A 128
ASP A 124
 None
 1.43A 5y9aA-2ligA:
undetectable		 5y9aA-2ligA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pth PEPTIDYL-TRNA
HYDROLASE

(Escherichia
coli) 		PF01195
(Pept_tRNA_hydro) 		4 ALA A  16
TRP A  25
GLN A 158
ASP A 162
 None
 0.24A 5y9aA-2pthA:
32.7		 5y9aA-2pthA:
52.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgu PROBABLE SIGNAL
PEPTIDE PROTEIN

(Ralstonia
solanacearum) 		PF05494
(MlaC) 		4 ALA A  89
GLN A  94
GLN A  95
ASP A  99
 None
 1.49A 5y9aA-2qguA:
undetectable		 5y9aA-2qguA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 ALA A 127
GLN A 130
GLN A 256
ASP A 133
 None
 1.25A 5y9aA-2rcbA:
undetectable		 5y9aA-2rcbA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		4 ALA A  53
GLN A  56
GLN A 229
ASP A 233
 None
 1.10A 5y9aA-2v7yA:
undetectable		 5y9aA-2v7yA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 ALA A 517
GLN A 399
GLN A 395
ASP A 393
 None
 1.06A 5y9aA-2x3kA:
undetectable		 5y9aA-2x3kA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 ALA A 139
GLN A 138
GLN A 206
ASP A 204
 None
 1.06A 5y9aA-2yv2A:
3.9		 5y9aA-2yv2A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 ALA A 400
GLN A 292
LYS A 255
ASP A 406
 None
 1.39A 5y9aA-2zciA:
undetectable		 5y9aA-2zciA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flu DIHYDRODIPICOLINATE
SYNTHASE

(Neisseria
meningitidis) 		PF00701
(DHDPS) 		4 ALA A 220
GLN A 223
GLN A   3
ASP A  37
 None
 1.46A 5y9aA-3fluA:
undetectable		 5y9aA-3fluA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pst PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		4 ALA A 619
GLN A 616
LYS A 613
ASP A 395
 None
 1.29A 5y9aA-3pstA:
undetectable		 5y9aA-3pstA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r20 CYTIDYLATE KINASE

(Mycolicibacterium
smegmatis) 		PF02224
(Cytidylate_kin) 		4 ALA A 161
GLN A 162
GLN A 210
ASP A 209
 None
DPO  A 230 (-2.9A)
None
None
 1.39A 5y9aA-3r20A:
2.3		 5y9aA-3r20A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Listeria
monocytogenes) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 ALA A 108
LYS A 193
GLN A 197
ASP A 201
 None
 1.44A 5y9aA-3tx1A:
undetectable		 5y9aA-3tx1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE

(Agrobacterium
fabrum) 		PF00561
(Abhydrolase_1) 		4 ALA A 227
GLN A 226
GLN A  87
ASP A  91
 None
 1.33A 5y9aA-3wibA:
2.0		 5y9aA-3wibA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apb FUMARATE HYDRATASE
CLASS II

(Mycobacterium
tuberculosis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ALA A 251
GLN A 252
GLN A  63
ASP A  67
 None
 1.36A 5y9aA-4apbA:
undetectable		 5y9aA-4apbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b93 ANKYRIN REPEAT
DOMAIN-CONTAINING
PROTEIN 27
VESICLE-ASSOCIATED
MEMBRANE PROTEIN 7

(Homo sapiens;
Mus musculus) 		PF00957
(Synaptobrevin)
PF12796
(Ank_2)
PF13774
(Longin)
PF13857
(Ank_5) 		4 ALA A 131
GLN A 132
LYS A 128
ASP B 679
 None
 1.27A 5y9aA-4b93A:
undetectable		 5y9aA-4b93A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fff LEVAN
FRUCTOTRANSFERASE

(Paenarthrobacter
ureafaciens) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ALA A  41
GLN A 472
GLN A 488
ASP A 296
 None
 1.40A 5y9aA-4fffA:
undetectable		 5y9aA-4fffA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ALA A 603
GLN A 606
LYS A 610
GLN A 609
 None
 1.39A 5y9aA-4fn5A:
3.9		 5y9aA-4fn5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		4 ALA A 201
GLN A 202
GLN A 210
ASP A 214
 None
 1.48A 5y9aA-4im7A:
undetectable		 5y9aA-4im7A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mo1 ANTITERMINATION
PROTEIN Q

(Escherichia
virus Lambda) 		PF03589
(Antiterm) 		4 ALA A 100
GLN A  97
GLN A  64
ASP A  62
 None
 1.35A 5y9aA-4mo1A:
undetectable		 5y9aA-4mo1A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oyd APOPTOSIS REGULATOR
BHRF1
COMPUTATIONALLY
DESIGNED INHIBITOR

(Human
gammaherpesvirus
4;
synthetic
construct) 		PF00452
(Bcl-2)
no annotation 		4 ALA B  63
GLN B  66
GLN B  69
ASP A 156
 None
 1.47A 5y9aA-4oydB:
undetectable		 5y9aA-4oydB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rya ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL)

(Agrobacterium
vitis) 		PF01547
(SBP_bac_1) 		4 ALA A 419
LYS A 222
GLN A 226
ASP A 230
 None
 1.42A 5y9aA-4ryaA:
undetectable		 5y9aA-4ryaA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uow OBSCURIN
TITIN

(Homo sapiens) 		PF07679
(I-set) 		4 ALA 1  94
GLN 1  79
GLN 1  47
ASP 0  13
 None
 1.31A 5y9aA-4uow1:
undetectable		 5y9aA-4uow1:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 ALA A 277
GLN A 281
GLN A 253
ASP A 257
 None
 1.46A 5y9aA-4xwtA:
undetectable		 5y9aA-4xwtA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E

(Alteromonas sp.) 		PF00557
(Peptidase_M24) 		4 ALA A 273
GLN A 277
GLN A 279
ASP A 421
 None
 1.47A 5y9aA-4zwoA:
undetectable		 5y9aA-4zwoA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 ALA A 287
GLN A 262
TRP A 286
ASP A 504
 None
None
None
NSQ  A1681 ( 4.7A)
 1.41A 5y9aA-5aeeA:
undetectable		 5y9aA-5aeeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 ALA A 282
GLN A 283
GLN A 138
ASP A 134
 None
 1.27A 5y9aA-5allA:
3.3		 5y9aA-5allA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		4 ALA A 284
GLN A 283
GLN A 138
ASP A 134
 None
 1.36A 5y9aA-5allA:
3.3		 5y9aA-5allA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwf PEPTIDOGLYCAN
RECOGNITION PROTEIN
1

(Camelus
dromedarius) 		PF01510
(Amidase_2) 		4 ALA A  50
GLN A  54
TRP A  15
GLN A  57
 None
 1.25A 5y9aA-5dwfA:
undetectable		 5y9aA-5dwfA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 4 ALA I 351
GLN I 352
LYS I 371
GLN I 450
 None
 1.43A 5y9aA-5furI:
undetectable		 5y9aA-5furI:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 ALA A 571
GLN A 372
LYS A 375
GLN A 371
 None
 1.16A 5y9aA-5gl7A:
2.5		 5y9aA-5gl7A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inf CARBOXYL TRANSFERASE

(Streptomyces
ambofaciens) 		PF01039
(Carboxyl_trans) 		4 ALA A 521
GLN A 520
LYS A 518
ASP A 365
 None
 0.97A 5y9aA-5infA:
2.4		 5y9aA-5infA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		4 ALA A  50
LYS A  78
GLN A  75
ASP A  71
 None
 1.30A 5y9aA-5loaA:
1.8		 5y9aA-5loaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		4 ALA A  10
GLN A  11
GLN A 150
ASP A 149
 None
TRP  A 402 (-4.2A)
TRP  A 402 (-3.1A)
AMP  A 401 ( 4.9A)
 1.46A 5y9aA-5v0iA:
undetectable		 5y9aA-5v0iA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6a31 PEPTIDYL-TRNA
HYDROLASE

(Acinetobacter
baumannii) 		no annotation 6 ALA A  18
GLN A  19
TRP A  27
LYS A 152
GLN A 158
ASP A 162
 None
 0.58A 5y9aA-6a31A:
38.5		 5y9aA-6a31A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejb XYLOSYLTRANSFERASE 1

(Homo sapiens) 		no annotation 4 ALA A 338
GLN A 341
GLN A 606
ASP A 693
 None
 1.09A 5y9aA-6ejbA:
undetectable		 5y9aA-6ejbA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbh HOPQ

(Helicobacter
pylori) 		no annotation 4 ALA C 285
GLN C 286
GLN C 221
ASP C 219
 None
 1.40A 5y9aA-6gbhC:
undetectable		 5y9aA-6gbhC:
18.65