SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y80_A_IREA402_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwp EBULIN

(Sambucus ebulus) 		PF00652
(Ricin_B_lectin) 		5 ALA B  83
VAL B  92
ILE B  98
ASN B 100
ILE B  15
 None
 1.32A 5y80A-1hwpB:
undetectable		 5y80A-1hwpB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwp EBULIN

(Sambucus ebulus) 		PF00652
(Ricin_B_lectin) 		5 ALA B  84
VAL B  92
ILE B  98
ASN B 100
ILE B  15
 None
 1.17A 5y80A-1hwpB:
undetectable		 5y80A-1hwpB:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ig8 HEXOKINASE PII

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 SER A 158
ILE A 467
THR A 213
ILE A 166
GLN A 163
 None
 1.24A 5y80A-1ig8A:
0.0		 5y80A-1ig8A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		5 ALA A 786
ASP A 697
VAL A 708
ILE A 704
ASN A 703
 None
 0.89A 5y80A-1p15A:
0.9		 5y80A-1p15A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q44 STEROID
SULFOTRANSFERASE

(Arabidopsis
thaliana) 		PF00685
(Sulfotransfer_1) 		5 ASP A  65
SER A 154
HIS A 143
VAL A  71
ILE A  69
 None
 1.33A 5y80A-1q44A:
0.0		 5y80A-1q44A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		5 ALA A 106
SER A  83
VAL A  43
THR A  39
ILE A 180
 None
 1.25A 5y80A-1smlA:
undetectable		 5y80A-1smlA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u14 HYPOTHETICAL UPF0244
PROTEIN YJJX

(Salmonella
enterica) 		PF01931
(NTPase_I-T) 		5 ALA A 119
ARG A 150
VAL A  88
ILE A  75
THR A   8
 None
PO4  A 201 (-2.7A)
None
None
None
 1.32A 5y80A-1u14A:
0.0		 5y80A-1u14A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		5 ALA A  98
ASP A 879
VAL A 795
ILE A 925
ILE A 961
 None
 1.21A 5y80A-1uf2A:
0.0		 5y80A-1uf2A:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 ASP A 232
SER A 235
ILE A 252
THR A 188
ILE A 268
 None
 1.13A 5y80A-1uz5A:
0.0		 5y80A-1uz5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 ASP A 232
VAL A 250
ILE A 252
THR A 188
ILE A 268
 None
 1.23A 5y80A-1uz5A:
0.0		 5y80A-1uz5A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2b PROLINE
IMINOPEPTIDASE

(Serratia
marcescens) 		PF00561
(Abhydrolase_1) 		5 ALA A  13
ASP A  70
VAL A 109
ILE A  43
ILE A  95
 None
 1.05A 5y80A-1x2bA:
0.0		 5y80A-1x2bA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi3 THIAMINE PHOSPHATE
PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF02581
(TMP-TENI) 		5 ALA A 194
ASP A  14
VAL A 158
ILE A 160
GLN A  36
 None
 1.34A 5y80A-1xi3A:
undetectable		 5y80A-1xi3A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yif BETA-1,4-XYLOSIDASE

(Bacillus
subtilis) 		PF04616
(Glyco_hydro_43) 		5 ALA A 507
HIS A  40
VAL A   7
THR A 265
ILE A  26
 None
 1.25A 5y80A-1yifA:
undetectable		 5y80A-1yifA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		5 ASP A  86
SER A  87
ILE A 242
ASN A 245
ILE A  47
 None
 1.05A 5y80A-1ym0A:
undetectable		 5y80A-1ym0A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4a DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Plasmodium
yoelii) 		PF01791
(DeoC) 		5 ALA A  74
ASP A 168
VAL A 146
ILE A 144
ILE A 189
 None
 1.34A 5y80A-2a4aA:
undetectable		 5y80A-2a4aA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bc0 NADH OXIDASE

(Streptococcus
pyogenes) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A  73
ASP A  34
VAL A 287
THR A 111
ILE A  84
 None
FAD  A 601 (-2.9A)
None
FAD  A 601 (-4.1A)
None
 1.25A 5y80A-2bc0A:
undetectable		 5y80A-2bc0A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btw ALR0975 PROTEIN

(Nostoc sp. PCC
7120) 		PF05023
(Phytochelatin) 		5 ALA A  68
ARG A 173
ILE A 199
ILE A 176
GLN A 178
 None
 1.28A 5y80A-2btwA:
undetectable		 5y80A-2btwA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg0 DRP35

(Staphylococcus
aureus) 		PF08450
(SGL) 		5 ALA A 188
ASP A 236
SER A 237
VAL A 312
ILE A 296
 None
 1.31A 5y80A-2dg0A:
undetectable		 5y80A-2dg0A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		5 ASP A 110
SER A  13
VAL A  31
ILE A  27
ILE A   9
 None
 1.35A 5y80A-2iyfA:
undetectable		 5y80A-2iyfA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k7q FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		5 VAL A2090
ILE A2092
ASN A2093
THR A2094
ILE A2116
 None
 1.27A 5y80A-2k7qA:
undetectable		 5y80A-2k7qA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o56 PUTATIVE MANDELATE
RACEMASE

(Salmonella
enterica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A  33
VAL A  28
ILE A  30
ASN A  31
ILE A  64
 None
 1.22A 5y80A-2o56A:
undetectable		 5y80A-2o56A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ral SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN G

(Staphylococcus
epidermidis) 		PF10425
(SdrG_C_C) 		5 ASP A 482
VAL A 488
ILE A 486
THR A 484
ILE A 528
 None
 1.21A 5y80A-2ralA:
undetectable		 5y80A-2ralA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 ALA A  16
VAL A  11
ILE A  85
THR A  31
ILE A  93
 None
 1.09A 5y80A-2rkfA:
undetectable		 5y80A-2rkfA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00809
(Pterin_bind) 		5 ALA A 130
ASP A  51
SER A  89
ILE A  80
ILE A  43
 None
 1.23A 5y80A-2vefA:
undetectable		 5y80A-2vefA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxy CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 ALA A 240
VAL A 194
ILE A 197
ASN A 263
ILE A 162
 None
 1.13A 5y80A-2vxyA:
undetectable		 5y80A-2vxyA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfo GLYCOPROTEIN 1

(Machupo
mammarenavirus) 		PF00798
(Arena_glycoprot) 		5 ASP A 222
SER A 224
VAL A 215
ILE A 217
ASN A 174
 NAG  A1243 ( 4.1A)
None
None
None
None
 1.30A 5y80A-2wfoA:
undetectable		 5y80A-2wfoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnx GLYCOSIDE HYDROLASE,
FAMILY 9

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		5 SER A  14
ILE A 114
ASN A  34
THR A 111
ILE A  96
 None
 1.20A 5y80A-2wnxA:
undetectable		 5y80A-2wnxA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdh COHESIN

(Archaeoglobus
fulgidus) 		PF00963
(Cohesin) 		5 ALA A 127
SER A  41
VAL A 145
ILE A 133
ILE A  36
 None
 1.03A 5y80A-2xdhA:
undetectable		 5y80A-2xdhA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ALA A 168
SER A 161
ILE A 206
THR A 208
ILE A 232
 None
 1.12A 5y80A-3a2fA:
undetectable		 5y80A-3a2fA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ASP A 141
SER A 161
ILE A 206
THR A 208
ILE A 232
 None
 1.23A 5y80A-3a2fA:
undetectable		 5y80A-3a2fA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE

(Thermoplasma
acidophilum) 		PF07992
(Pyr_redox_2) 		6 ALA A  86
ASP A  46
VAL A 283
ILE A 120
THR A 122
ILE A  97
 None
FAD  A1000 (-2.8A)
None
None
FAD  A1000 (-3.9A)
None
 1.16A 5y80A-3ctyA:
undetectable		 5y80A-3ctyA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		5 ALA A  45
SER A  35
VAL A  92
ILE A  71
THR A  73
 None
 1.27A 5y80A-3e9mA:
undetectable		 5y80A-3e9mA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9m OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Enterococcus
faecalis) 		PF01408
(GFO_IDH_MocA) 		5 ALA A  53
SER A  35
VAL A  92
ILE A  71
THR A  73
 None
 1.23A 5y80A-3e9mA:
undetectable		 5y80A-3e9mA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 ALA A 350
VAL A 309
ILE A 324
ASN A 325
THR A 326
 None
 0.98A 5y80A-3eqqA:
undetectable		 5y80A-3eqqA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		5 ALA A 177
ASP A 219
SER A 180
VAL A 246
ILE A 161
 None
 1.20A 5y80A-3fkqA:
undetectable		 5y80A-3fkqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkq NTRC-LIKE TWO-DOMAIN
PROTEIN

([Eubacterium]
rectale) 		PF13614
(AAA_31) 		5 ALA A 177
ASP A 219
SER A 180
VAL A 246
ILE A 228
 None
 1.03A 5y80A-3fkqA:
undetectable		 5y80A-3fkqA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 284
ILE A 288
ASN A 291
THR A 292
ILE A 273
 None
 0.87A 5y80A-3gbrA:
undetectable		 5y80A-3gbrA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		5 ALA A 126
HIS A 263
VAL A 268
ILE A 269
THR A 136
 None
 1.34A 5y80A-3hc1A:
0.6		 5y80A-3hc1A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ALA B 626
VAL B 604
ILE B 606
ILE B 542
GLN B 533
 None
 1.32A 5y80A-3hhsB:
undetectable		 5y80A-3hhsB:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyv SULFIDE-QUINONE
REDUCTASE

(Aquifex
aeolicus) 		PF07992
(Pyr_redox_2) 		5 ASP A  35
SER A  34
ILE A 103
THR A 105
ILE A  81
 FAD  A 441 (-3.2A)
FAD  A 441 (-3.4A)
None
FAD  A 441 (-4.2A)
None
 0.93A 5y80A-3hyvA:
undetectable		 5y80A-3hyvA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ius UNCHARACTERIZED
CONSERVED PROTEIN

(Ruegeria
pomeroyi) 		no annotation 5 ALA A  46
VAL A  95
ILE A  66
THR A  68
ILE A  85
 None
 1.17A 5y80A-3iusA:
undetectable		 5y80A-3iusA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js6 UNCHARACTERIZED PARM
PROTEIN

(Staphylococcus
aureus) 		no annotation 5 ASP A  10
VAL A 114
ILE A 116
THR A 118
ILE A 100
 None
 1.07A 5y80A-3js6A:
undetectable		 5y80A-3js6A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		5 ALA A 264
ASP A  37
VAL A 109
ILE A  26
ILE A 276
 None
 1.14A 5y80A-3khsA:
undetectable		 5y80A-3khsA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 ALA A 256
ASP A 126
VAL A 305
ILE A 285
ILE A  61
 None
 1.35A 5y80A-3m1rA:
undetectable		 5y80A-3m1rA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4e ALPHA-HEMOLYSIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		5 ASP A 285
ILE A 245
ASN A 244
THR A 243
ILE A  55
 None
 1.25A 5y80A-3m4eA:
undetectable		 5y80A-3m4eA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4e ALPHA-HEMOLYSIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		5 ASP A 285
VAL A 247
ILE A 245
THR A 243
ILE A  55
 None
 1.17A 5y80A-3m4eA:
undetectable		 5y80A-3m4eA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3net HISTIDYL-TRNA
SYNTHETASE

(Nostoc sp. PCC
7120) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 ASP A 248
SER A 245
VAL A 280
ILE A 277
ILE A 181
 None
 1.20A 5y80A-3netA:
2.1		 5y80A-3netA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqh GLYCOSYL HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 ALA A 407
ARG A 413
ASP A 402
ILE A  31
THR A 294
 None
 1.31A 5y80A-3nqhA:
undetectable		 5y80A-3nqhA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II

(Listeria
monocytogenes) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ASP A 173
VAL A 147
ILE A 105
THR A 159
ILE A 237
 None
 1.27A 5y80A-3o04A:
undetectable		 5y80A-3o04A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4e PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Vibrio cholerae) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 315
ASP A 180
VAL A 302
ILE A 305
ILE A 269
 None
 1.08A 5y80A-3p4eA:
undetectable		 5y80A-3p4eA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm8 CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF13499
(EF-hand_7) 		5 SER A 339
VAL A 414
ASN A 345
THR A 435
ILE A 395
 None
 1.26A 5y80A-3pm8A:
undetectable		 5y80A-3pm8A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		5 ALA A 176
SER A 139
VAL A  88
ILE A  81
THR A  41
 None
 1.31A 5y80A-3pukA:
undetectable		 5y80A-3pukA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		5 ALA A 759
ASP A 847
SER A 805
ILE A 869
ILE A 835
 None
 1.25A 5y80A-3sfzA:
undetectable		 5y80A-3sfzA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 ALA A 300
VAL A 254
ILE A 258
ASN A 261
THR A 262
 None
 1.31A 5y80A-3uhjA:
undetectable		 5y80A-3uhjA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3upy OXIDOREDUCTASE

(Brucella
abortus) 		PF03447
(NAD_binding_3) 		5 ASP A  37
SER A 326
VAL A 110
ILE A  26
ILE A  48
 None
 1.27A 5y80A-3upyA:
undetectable		 5y80A-3upyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 ASP A  43
SER A  39
VAL A  27
ILE A 540
ILE A   4
 None
 1.05A 5y80A-3ux8A:
undetectable		 5y80A-3ux8A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avo BETA-1,4-EXOCELLULAS
E

(Thermobifida
fusca) 		PF01341
(Glyco_hydro_6) 		5 SER A 427
ILE A 361
ASN A 363
THR A 364
GLN A 216
 None
 1.17A 5y80A-4avoA:
undetectable		 5y80A-4avoA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c51 CATALASE-PEROXIDASE

(Mycobacterium
tuberculosis) 		PF00141
(peroxidase) 		5 ASP A 542
SER A 539
VAL A 503
ILE A 497
ILE A 518
 None
 1.34A 5y80A-4c51A:
undetectable		 5y80A-4c51A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egf L-XYLULOSE REDUCTASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ALA A  85
ASP A  96
VAL A 152
ILE A 150
ILE A  32
 None
 1.17A 5y80A-4egfA:
undetectable		 5y80A-4egfA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 SER A 641
HIS A 558
ILE A 699
ASN A 696
ILE A 554
 None
 1.29A 5y80A-4fm9A:
3.3		 5y80A-4fm9A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gib BETA-PHOSPHOGLUCOMUT
ASE

(Clostridioides
difficile) 		PF13419
(HAD_2) 		5 ALA A 116
SER A 114
VAL A 189
ILE A 169
ILE A  97
 PO4  A 303 (-3.9A)
None
None
None
None
 1.21A 5y80A-4gibA:
undetectable		 5y80A-4gibA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ASP X 317
SER X 319
VAL X 330
THR X 195
ILE X 113
 None
 1.25A 5y80A-4hscX:
undetectable		 5y80A-4hscX:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5s PUTATIVE HISTIDINE
KINASE COVS
VICK-LIKE PROTEIN

(Streptococcus
mutans) 		PF00512
(HisKA)
PF00989
(PAS)
PF02518
(HATPase_c) 		5 ALA A 417
SER A 425
ILE A 340
ASN A 338
ILE A 311
 None
 1.16A 5y80A-4i5sA:
undetectable		 5y80A-4i5sA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 ALA A  36
ASP A 192
VAL A 281
ILE A 232
ILE A 200
 None
 1.33A 5y80A-4kg7A:
undetectable		 5y80A-4kg7A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldg PROTEIN WITH A SET
DOMAIN WITHIN
CARBOXY REGION

(Cryptosporidium
parvum) 		PF00856
(SET) 		5 ALA A 199
ASP A 263
VAL A 164
ILE A 230
ILE A 221
 None
 1.27A 5y80A-4ldgA:
undetectable		 5y80A-4ldgA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		5 ALA D  92
ASP D 101
VAL D 176
ILE D 175
GLN D  29
 None
 1.25A 5y80A-4mwaD:
undetectable		 5y80A-4mwaD:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3s EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 ALA A 701
ILE A 496
ASN A 495
THR A 616
ILE A 498
 None
 1.31A 5y80A-4n3sA:
undetectable		 5y80A-4n3sA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6c UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF08020
(DUF1706) 		5 VAL A 145
ILE A 149
ASN A 152
THR A 153
ILE A 117
 None
 1.23A 5y80A-4n6cA:
undetectable		 5y80A-4n6cA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nek ENOYL-COA
HYDRATASE/CARNITHINE
RACEMASE

(Magnetospirillum
magneticum) 		PF00378
(ECH_1) 		5 ALA A 145
SER A 140
VAL A  87
ILE A  84
ILE A 105
 None
 1.07A 5y80A-4nekA:
undetectable		 5y80A-4nekA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens;
Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF17205
(PSI_integrin) 		5 ALA A 611
ASP A 760
SER A 885
THR A 798
ILE B 482
 None
 1.34A 5y80A-4nenA:
undetectable		 5y80A-4nenA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0m L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 ALA A 162
SER A 109
ILE A  78
THR A  80
ILE A 128
 None
 1.25A 5y80A-4q0mA:
undetectable		 5y80A-4q0mA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 ASP A 231
SER A 254
VAL A 224
ILE A 467
ILE A 258
 None
 1.31A 5y80A-4qi7A:
undetectable		 5y80A-4qi7A:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsl PYRUVATE CARBOXYLASE

(Listeria
monocytogenes) 		no annotation 5 SER H  89
HIS H 299
ASN H 292
ILE H 310
GLN H 314
 None
 1.33A 5y80A-4qslH:
1.3		 5y80A-4qslH:
5.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra6 L-ASPARAGINASE

(Pyrococcus
furiosus) 		PF00710
(Asparaginase) 		5 ALA A 162
SER A 109
ILE A  78
THR A  80
ILE A 128
 None
 1.23A 5y80A-4ra6A:
undetectable		 5y80A-4ra6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkx LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 ALA L 584
SER L 511
VAL L 521
ASN L 475
THR L 442
 None
TCK  L 720 (-2.6A)
NA  L 706 (-4.9A)
None
TCK  L 720 (-3.5A)
 0.96A 5y80A-4tkxL:
undetectable		 5y80A-4tkxL:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zya ASPARAGINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 5 ASP A  47
SER A   9
ILE A  44
ILE A  66
GLN A  62
 None
 1.31A 5y80A-4zyaA:
undetectable		 5y80A-4zyaA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeb LRA-12

(uncultured
bacterium BLR12) 		PF00753
(Lactamase_B) 		5 ASP A 184
VAL A  83
ILE A  81
THR A  75
ILE A 180
 None
 1.16A 5y80A-5aebA:
undetectable		 5y80A-5aebA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA
PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF01008
(IF-2B)
PF01008
(IF-2B) 		5 SER G 301
HIS C 243
VAL C 231
ILE C 259
THR C 263
 None
 1.23A 5y80A-5b04G:
2.7		 5y80A-5b04G:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cog IRC4

(Saccharomyces
cerevisiae) 		PF08020
(DUF1706) 		5 VAL A 142
ILE A 146
ASN A 149
THR A 150
ILE A 117
 None
 1.20A 5y80A-5cogA:
undetectable		 5y80A-5cogA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5com PUTATIVE CONJUGATIVE
TRANSPOSON PROTEIN
TN1549-LIKE,
CTN5-ORF2

(Clostridioides
difficile) 		PF08020
(DUF1706) 		5 VAL A 156
ILE A 160
ASN A 163
THR A 164
ILE A 128
 None
None
TAR  A 201 (-2.3A)
None
None
 1.15A 5y80A-5comA:
undetectable		 5y80A-5comA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzz DESMOPLAKIN

(Homo sapiens) 		PF00681
(Plectin) 		5 ARG A2385
ASP A2252
SER A2257
ILE A2372
ILE A2377
 None
 1.26A 5y80A-5dzzA:
undetectable		 5y80A-5dzzA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e52 CONTACTIN-5

(Homo sapiens) 		PF00041
(fn3) 		5 ALA A 877
ARG A 783
VAL A 866
ILE A 868
ILE A 792
 None
 1.30A 5y80A-5e52A:
undetectable		 5y80A-5e52A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fk0 COATOMER SUBUNIT
DELTA

(Saccharomyces
cerevisiae) 		PF00928
(Adap_comp_sub) 		5 VAL A 443
ILE A 445
ASN A 446
THR A 447
ILE A 468
 None
 1.26A 5y80A-5fk0A:
undetectable		 5y80A-5fk0A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Cyanothece sp.
ATCC 51142) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 HIS A 122
ILE A 177
ASN A 174
THR A 176
ILE A 125
 None
 1.33A 5y80A-5gr1A:
2.4		 5y80A-5gr1A:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 224
ASP A 203
VAL A 233
ILE A 241
GLN A 257
 None
 1.17A 5y80A-5gz8A:
19.7		 5y80A-5gz8A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 ARG A 179
ASP A 180
SER A 201
ILE A 221
ILE A 243
 None
 0.72A 5y80A-5i3oA:
10.0		 5y80A-5i3oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		5 ALA A 224
ASP A 166
SER A 226
ILE A  77
ASN A  78
 None
FEO  A 501 ( 2.5A)
FEO  A 501 ( 4.3A)
None
None
 1.34A 5y80A-5lmcA:
undetectable		 5y80A-5lmcA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ALA A   9
ASP A 777
SER A 779
VAL A 445
THR A 756
 None
 1.32A 5y80A-5m2nA:
undetectable		 5y80A-5m2nA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5j THIOREDOXIN
REDUCTASE

(Giardia
intestinalis) 		PF07992
(Pyr_redox_2) 		5 ALA A  77
VAL A 278
ILE A 112
THR A 114
ILE A  87
 None
None
None
FAD  A1001 (-3.9A)
None
 0.99A 5y80A-5m5jA:
undetectable		 5y80A-5m5jA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 5 ALA A  17
ASP A  14
SER A  15
ILE A 215
ILE A   9
 None
 1.22A 5y80A-5m86A:
1.6		 5y80A-5m86A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 5 ALA A1758
SER A1552
ILE A1528
ASN A1529
GLN A1795
 None
 1.25A 5y80A-5nnlA:
undetectable		 5y80A-5nnlA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ALA A 163
ASP A 194
VAL A 331
ILE A 332
ILE A 203
 None
 1.21A 5y80A-5t9jA:
undetectable		 5y80A-5t9jA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF13561
(adh_short_C2) 		5 ALA A 231
VAL A 176
ILE A 178
ASN A 179
ILE A 120
 None
 1.25A 5y80A-5va8A:
undetectable		 5y80A-5va8A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vha DEAH
(ASP-GLU-ALA-HIS)
BOX POLYPEPTIDE 36

(Bos taurus) 		no annotation 5 ALA A 590
ASP A 473
HIS A 615
VAL A 568
ILE A 569
 None
 1.30A 5y80A-5vhaA:
undetectable		 5y80A-5vhaA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
ambifaria) 		PF13561
(adh_short_C2) 		5 ALA A 231
VAL A 176
ILE A 178
ASN A 179
ILE A 120
 None
 1.24A 5y80A-5vpsA:
undetectable		 5y80A-5vpsA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 5 ALA B 368
VAL B 425
ILE B 240
ASN B 388
GLN B 243
 None
 1.32A 5y80A-5wwpB:
undetectable		 5y80A-5wwpB:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A  36
VAL A  73
ILE A  75
THR A 118
ILE A 102
 None
 1.10A 5y80A-6aooA:
undetectable		 5y80A-6aooA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo0 MDBA PROTEIN

(Corynebacterium
matruchotii) 		no annotation 5 ASP A  88
SER A 221
VAL A 116
ILE A 118
THR A 120
 CSO  A  91 ( 4.7A)
CSO  A  91 ( 2.2A)
None
None
None
 1.03A 5y80A-6bo0A:
undetectable		 5y80A-6bo0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 5 ASP A 414
SER A 417
VAL A 424
ILE A 423
ASN A 419
 None
 0.99A 5y80A-6c01A:
undetectable		 5y80A-6c01A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 ALA O  39
ARG O 126
VAL O 179
ILE O  31
ILE O 202
 None
ADP  O 401 ( 4.3A)
None
ADP  O 401 (-4.0A)
None
 1.26A 5y80A-6g2jO:
undetectable		 5y80A-6g2jO:
25.26