SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y80_A_IREA401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
GLU A 236
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.63A 5y80A-1k9aA:
23.8		 5y80A-1k9aA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.51A 5y80A-1opkA:
22.8		 5y80A-1opkA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		8 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.95A 5y80A-1q8yA:
23.1		 5y80A-1q8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
LEU A 818
ASP A 829
 None
 0.75A 5y80A-1rjbA:
20.8		 5y80A-1rjbA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
VAL A 603
ALA A 621
GLU A 640
THR A 670
CYH A 673
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.50A 5y80A-1t46A:
22.6		 5y80A-1t46A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
CYH A 673
GLY A 676
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
 0.59A 5y80A-1t46A:
22.6		 5y80A-1t46A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.52A 5y80A-1u59A:
23.7		 5y80A-1u59A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 None
 0.55A 5y80A-1u5qA:
24.4		 5y80A-1u5qA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.55A 5y80A-1zltA:
23.1		 5y80A-1zltA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  95
ASP A 161
 None
None
GOL  A3001 (-3.5A)
None
None
None
None
 0.63A 5y80A-2a2aA:
25.9		 5y80A-2a2aA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.62A 5y80A-2bujA:
29.7		 5y80A-2bujA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
THR X  82
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.61A 5y80A-2dq7X:
24.2		 5y80A-2dq7X:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
LEU A 238
GLY A 240
LEU A 290
ASP A 320
 None
 0.88A 5y80A-2eu9A:
24.5		 5y80A-2eu9A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.45A 5y80A-2gcdA:
24.3		 5y80A-2gcdA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
THR A 338
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.63A 5y80A-2h8hA:
21.7		 5y80A-2h8hA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
VAL A 256
ALA A 269
GLU A 286
THR A 315
GLY A 321
LEU A 370
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
 0.64A 5y80A-2hz0A:
22.8		 5y80A-2hz0A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
VAL A 256
ALA A 269
LYS A 271
GLU A 286
THR A 315
GLY A 321
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.9A)
 0.78A 5y80A-2hz0A:
22.8		 5y80A-2hz0A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		9 VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.60A 5y80A-2j0jA:
23.2		 5y80A-2j0jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
THR A 316
GLY A 322
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.85A 5y80A-2og8A:
21.6		 5y80A-2og8A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 588
VAL A 596
ALA A 614
GLU A 633
THR A 663
CYH A 666
GLY A 669
LEU A 785
ASP A 796
 None
 0.86A 5y80A-2ogvA:
21.2		 5y80A-2ogvA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		9 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A 105
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.64A 5y80A-2phkA:
27.1		 5y80A-2phkA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 724
VAL A 732
ALA A 749
THR A 796
LEU A 798
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.63A 5y80A-2r4bA:
20.7		 5y80A-2r4bA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  95
ASP A 161
 ADP  A1303 ( 3.9A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
MG  A1304 ( 2.8A)
 0.55A 5y80A-2w4kA:
25.8		 5y80A-2w4kA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A 445
LYS A 447
GLU A 459
THR A 489
LEU A 491
GLY A 495
LEU A 542
ASP A 557
 None
 0.78A 5y80A-2wntA:
22.0		 5y80A-2wntA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
LYS A  49
GLU A  66
GLY A 101
LEU A 147
ASP A 158
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.6A)
 0.62A 5y80A-2xikA:
25.1		 5y80A-2xikA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
VAL A  27
ALA A  40
LYS A  42
GLU A  64
LEU A  95
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.1A)
 0.55A 5y80A-2yabA:
26.1		 5y80A-2yabA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
VAL A  76
ALA A  92
LYS A  94
GLY A 147
LEU A 194
ASP A 205
 STU  A   1 (-3.8A)
None
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.54A 5y80A-2z7rA:
23.3		 5y80A-2z7rA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
ASP A 236
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
STU  A 400 ( 3.8A)
 0.60A 5y80A-3a62A:
6.5		 5y80A-3a62A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
ASP A 641
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
 0.81A 5y80A-3c4fA:
21.6		 5y80A-3c4fA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 209
ALA A 220
GLU A 236
THR A 266
GLY A 272
LEU A 321
ASP A 332
 None
 0.63A 5y80A-3d7uA:
24.4		 5y80A-3d7uA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 ALA A  37
LYS A  39
GLU A  60
LEU A  91
CYH A  92
GLY A  95
LEU A 182
ASP A 195
 ANP  A 329 ( 3.7A)
ANP  A 329 (-2.7A)
MG  A 330 ( 4.6A)
ANP  A 329 ( 4.7A)
ANP  A 329 (-4.1A)
None
ANP  A 329 (-4.4A)
MG  A 330 ( 2.9A)
 1.11A 5y80A-3hkoA:
23.6		 5y80A-3hkoA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 VAL A  24
ALA A  37
LYS A  39
GLU A  60
LEU A  91
CYH A  92
GLY A  94
LEU A 182
 ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-2.7A)
MG  A 330 ( 4.6A)
ANP  A 329 ( 4.7A)
ANP  A 329 (-4.1A)
None
ANP  A 329 (-4.4A)
 1.12A 5y80A-3hkoA:
23.6		 5y80A-3hkoA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		8 VAL A  24
ALA A  37
LYS A  39
GLU A  60
LEU A  91
CYH A  92
GLY A  95
LEU A 182
 ANP  A 329 (-4.4A)
ANP  A 329 ( 3.7A)
ANP  A 329 (-2.7A)
MG  A 330 ( 4.6A)
ANP  A 329 ( 4.7A)
ANP  A 329 (-4.1A)
None
ANP  A 329 (-4.4A)
 1.07A 5y80A-3hkoA:
23.6		 5y80A-3hkoA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
None
 0.66A 5y80A-3hngA:
22.0		 5y80A-3hngA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 432
ALA A 453
LYS A 455
GLU A 468
LEU A 500
LEU A 551
ASP A 565
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
ANP  A 400 (-4.6A)
ANP  A 400 (-4.7A)
None
 0.62A 5y80A-3kn5A:
22.1		 5y80A-3kn5A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
LYS A 667
GLU A 684
THR A 713
GLY A 719
LEU A 767
ASP A 778
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.74A 5y80A-3kulA:
24.4		 5y80A-3kulA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		8 LEU A 680
VAL A 689
ALA A 700
GLU A 715
LEU A 747
CYH A 748
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-4.2A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.78A 5y80A-3lj0A:
24.1		 5y80A-3lj0A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.70A 5y80A-3mdyA:
24.0		 5y80A-3mdyA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
None
 0.69A 5y80A-3mvjA:
24.0		 5y80A-3mvjA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 265
GLY A 269
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.0A)
 0.88A 5y80A-3nyoA:
23.9		 5y80A-3nyoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 726
VAL A 734
ALA A 751
LYS A 753
THR A 798
LEU A 800
GLY A 804
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.78A 5y80A-3pp0A:
21.6		 5y80A-3pp0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 VAL A 565
ALA A 576
LYS A 578
GLU A 596
THR A 625
GLY A 631
LEU A 683
ASP A 694
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.70A 5y80A-3ppzA:
24.8		 5y80A-3ppzA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
ALA A  84
GLU A 115
THR A 144
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
ANP  A1634 (-4.6A)
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.69A 5y80A-3q5iA:
22.7		 5y80A-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.77A 5y80A-3q5iA:
22.7		 5y80A-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  50
VAL A  58
ALA A  71
LYS A  73
GLU A  84
GLY A 124
LEU A 173
ASP A 187
 I85  A 350 (-3.7A)
I85  A 350 (-4.9A)
I85  A 350 (-3.3A)
I85  A 350 (-2.8A)
None
I85  A 350 (-3.0A)
None
I85  A 350 (-3.3A)
 0.80A 5y80A-3sheA:
21.8		 5y80A-3sheA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
ASP A 641
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
 0.69A 5y80A-3tt0A:
21.9		 5y80A-3tt0A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.65A 5y80A-3txoA:
23.6		 5y80A-3txoA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.55A 5y80A-3vidA:
21.0		 5y80A-3vidA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
ASP A1046
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.4A)
 0.74A 5y80A-3wzdA:
21.3		 5y80A-3wzdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
ASP A 194
 939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
939  A1331 (-3.1A)
 0.62A 5y80A-4a4lA:
27.9		 5y80A-4a4lA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
LYS A 106
GLU A 125
GLY A 160
LEU A 208
ASP A 219
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.58A 5y80A-4aw2A:
23.8		 5y80A-4aw2A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
VAL A 254
ALA A 267
LYS A 269
GLU A 288
GLY A 324
LEU A 371
ASP A 382
 None
 0.73A 5y80A-4c0tA:
25.8		 5y80A-4c0tA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  30
ALA A  43
LYS A  45
GLU A  64
GLY A  99
LEU A 146
ASP A 157
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.61A 5y80A-4cfhA:
25.6		 5y80A-4cfhA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 653
LYS A 655
GLU A 672
THR A 701
GLY A 707
LEU A 773
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-4.5A)
 0.73A 5y80A-4ckrA:
21.9		 5y80A-4ckrA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.66A 5y80A-4crsA:
25.8		 5y80A-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
BX7  A 401 ( 3.7A)
 0.72A 5y80A-4eutA:
20.6		 5y80A-4eutA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
BX7  A 401 (-3.6A)
 0.60A 5y80A-4euuA:
22.6		 5y80A-4euuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A1122
VAL A1130
ALA A1148
GLU A1167
LEU A1198
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.90A 5y80A-4fodA:
22.2		 5y80A-4fodA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  37
ALA A  50
LYS A  52
GLU A  71
LEU A 102
GLY A 106
LEU A 153
ASP A 164
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.55A 5y80A-4fr4A:
23.6		 5y80A-4fr4A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		8 VAL A 416
ALA A 429
LYS A 431
GLU A 442
LEU A 473
GLY A 477
LEU A 524
ASP A 536
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 (-3.1A)
 0.65A 5y80A-4g3fA:
21.2		 5y80A-4g3fA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLU A 898
GLY A 935
LEU A 983
ASP A 994
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.76A 5y80A-4gl9A:
24.3		 5y80A-4gl9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
GLY A 908
LEU A 956
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.67A 5y80A-4hviA:
24.2		 5y80A-4hviA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
ASP A 270
 None
 0.80A 5y80A-4hzsA:
19.9		 5y80A-4hzsA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 132
VAL A 140
ALA A 156
THR A 205
LEU A 207
GLY A 211
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
 0.62A 5y80A-4id7A:
23.8		 5y80A-4id7A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
VAL A 414
ALA A 427
GLU A 440
LEU A 471
GLY A 475
LEU A 522
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.80A 5y80A-4idtA:
21.5		 5y80A-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
LEU A 471
GLY A 475
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 ( 3.4A)
 0.99A 5y80A-4idtA:
21.5		 5y80A-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
CYH A  89
GLY A  92
ASP A 157
 SU6  A 701 (-3.6A)
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
None
 0.54A 5y80A-4jlcA:
6.0		 5y80A-4jlcA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
VAL A  26
ALA A  39
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.53A 5y80A-4jxfA:
18.8		 5y80A-4jxfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		10 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
LEU A 148
CYH A 149
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.88A 5y80A-4mvfA:
23.0		 5y80A-4mvfA:
11.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 ALA A  67
GLU A  85
THR A 123
LEU A 125
CYH A 126
GLY A 128
GLN A 129
LEU A 180
ASP A 191
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
None
 0.67A 5y80A-4o38A:
34.1		 5y80A-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  46
VAL A  54
ALA A  67
GLU A  85
THR A 123
LEU A 125
CYH A 126
GLY A 128
LEU A 180
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
 0.47A 5y80A-4o38A:
34.1		 5y80A-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
THR A 123
LEU A 125
CYH A 126
GLY A 128
ASP A 191
 SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
 0.57A 5y80A-4o38A:
34.1		 5y80A-4o38A:
90.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.72A 5y80A-4oliA:
6.3		 5y80A-4oliA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.49A 5y80A-4rt7A:
22.3		 5y80A-4rt7A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		8 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.68A 5y80A-4wb7A:
24.3		 5y80A-4wb7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  52
VAL A  60
ALA A  72
LYS A  74
CYH A 129
GLY A 132
GLN A 133
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.81A 5y80A-4wsqA:
32.5		 5y80A-4wsqA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
CYH A 129
GLY A 132
LEU A 183
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 0.67A 5y80A-4wsqA:
32.5		 5y80A-4wsqA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.63A 5y80A-4xufA:
21.9		 5y80A-4xufA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 477
ALA A 488
LYS A 490
GLU A 509
THR A 539
GLY A 545
LEU A 595
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
 0.59A 5y80A-4yffA:
23.2		 5y80A-4yffA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
THR A 105
GLY A 111
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.84A 5y80A-4ysjA:
25.1		 5y80A-4ysjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		7 VAL A 548
ALA A 561
LYS A 563
THR A 611
LEU A 613
LEU A 664
ASP A 675
 4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-3.2A)
4ZS  A 901 (-4.7A)
4ZS  A 901 (-3.6A)
None
 0.57A 5y80A-5ezrA:
23.5		 5y80A-5ezrA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.85A 5y80A-5f1zA:
22.7		 5y80A-5f1zA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
VAL A 607
ALA A 625
GLU A 644
THR A 674
CYH A 677
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.46A 5y80A-5grnA:
22.5		 5y80A-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
THR A 674
CYH A 677
GLY A 680
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
 0.53A 5y80A-5grnA:
22.5		 5y80A-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
VAL A  28
ALA A  41
GLU A  61
LEU A  92
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.66A 5y80A-5hu3A:
26.3		 5y80A-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
LEU A  92
GLY A  96
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
MG  A 302 ( 3.3A)
 0.75A 5y80A-5hu3A:
26.3		 5y80A-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
CYH A 133
GLY A 136
LEU A 187
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-4.0A)
 0.72A 5y80A-5i3oA:
10.0		 5y80A-5i3oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.46A 5y80A-5j5tA:
22.5		 5y80A-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.58A 5y80A-5jznA:
25.1		 5y80A-5jznA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 163
ALA A 176
LYS A 178
GLU A 193
LEU A 230
LEU A 282
ASP A 295
 7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 ( 4.7A)
None
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.47A 5y80A-5lxdA:
22.9		 5y80A-5lxdA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 8 VAL A  25
ALA A  38
LYS A  40
GLU A  57
CYH A  89
GLY A  92
LEU A 139
ASP A 150
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.75A 5y80A-5tvtA:
25.0		 5y80A-5tvtA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A 116
VAL A 124
ALA A 137
GLU A 157
THR A 187
LEU A 189
CYH A 190
GLY A 191
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-3.5A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
EDO  A 402 ( 2.9A)
 0.82A 5y80A-5vcxA:
22.7		 5y80A-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
THR A 187
LEU A 189
CYH A 190
GLY A 191
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-3.5A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
 0.93A 5y80A-5vcxA:
22.7		 5y80A-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 LEU A 686
VAL A 694
ALA A 707
GLU A 725
GLY A 760
LEU A 810
ASP A 822
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.60A 5y80A-5vilA:
23.1		 5y80A-5vilA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 8 VAL A  27
ALA A  40
LYS A  42
GLU A  61
LEU A  97
GLY A 100
LEU A 148
ASP A 159
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-4.3A)
 0.99A 5y80A-6b2qA:
24.4		 5y80A-6b2qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0t CGMP-DEPENDENT
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 8 LEU A 366
VAL A 374
ALA A 388
LYS A 390
GLU A 409
CYH A 441
GLY A 444
ASP A 502
 EE4  A 701 ( 4.6A)
EE4  A 701 (-4.4A)
EE4  A 701 (-3.3A)
DMS  A 702 (-3.5A)
DMS  A 702 ( 4.2A)
EE4  A 701 (-4.6A)
None
DMS  A 702 ( 3.1A)
 0.85A 5y80A-6c0tA:
24.9		 5y80A-6c0tA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 VAL A 179
ALA A 192
LYS A 194
GLU A 236
LEU A 269
GLY A 273
LEU A 319
ASP A 330
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
F6J  A 501 ( 4.4A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
 0.65A 5y80A-6cmjA:
24.6		 5y80A-6cmjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 9 LEU A 169
VAL A 177
ALA A 191
LYS A 193
GLU A 208
LEU A 245
GLY A 247
LEU A 297
ASP A 327
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.7A)
None
None
3NG  A 501 (-4.5A)
 0.92A 5y80A-6fylA:
24.3		 5y80A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 1.00A 5y80A-6fyoA:
23.9		 5y80A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 9 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
None
3NG  A 501 (-4.3A)
 0.98A 5y80A-6fyvA:
24.1		 5y80A-6fyvA:
undetectable