SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y7Z_B_IREB401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  83
LYS A  85
GLU A  97
LEU A 130
LEU A 188
CYH A 199
ASP A 200
 None
 0.95A 5y7zB-1gngA:
16.8		 5y7zB-1gngA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A 164
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
ASP A 550
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
ADP  A 810 ( 3.0A)
 0.91A 5y7zB-1q8yA:
15.3		 5y7zB-1q8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 642
GLU A 661
CYH A 694
GLY A 697
LEU A 818
CYH A 828
ASP A 829
 None
 0.87A 5y7zB-1rjbA:
21.2		 5y7zB-1rjbA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
ALA A 621
GLU A 640
CYH A 673
GLY A 676
LEU A 799
CYH A 809
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
 0.58A 5y7zB-1t46A:
23.2		 5y7zB-1t46A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 344
ALA A 367
LYS A 369
GLU A 386
LEU A 412
GLY A 420
LEU A 468
ASP A 479
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
STU  A 100 (-3.5A)
 0.59A 5y7zB-1u59A:
24.0		 5y7zB-1u59A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 None
 0.59A 5y7zB-1u5qA:
17.9		 5y7zB-1u5qA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
ALA A  36
GLU A  55
LEU A  82
CYH A  87
GLY A  90
LEU A 137
ASP A 148
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
HYM  A 400 (-3.9A)
 0.77A 5y7zB-1zltA:
23.8		 5y7zB-1zltA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 None
GOL  A3001 (-3.5A)
None
None
None
None
None
 0.81A 5y7zB-2a2aA:
26.8		 5y7zB-2a2aA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  26
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
LEU A 155
ASP A 166
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
None
 0.89A 5y7zB-2bujA:
30.9		 5y7zB-2bujA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  73
LYS A  75
GLU A  89
LEU A 121
GLY A 123
LEU A 172
ASP A 188
 5ID  A1300 ( 3.8A)
None
None
5ID  A1300 (-4.5A)
None
5ID  A1300 (-4.6A)
None
 0.99A 5y7zB-2c47A:
21.9		 5y7zB-2c47A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		8 ALA A  39
LYS A  41
GLU A  55
LEU A  83
LEU A  87
GLY A  89
LEU A 138
ASP A 154
 CKI  A 300 (-3.6A)
None
None
None
None
None
CKI  A 300 (-4.4A)
CKI  A 300 (-4.4A)
 1.02A 5y7zB-2csnA:
23.9		 5y7zB-2csnA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
ALA X  37
LYS X  39
GLU X  54
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.63A 5y7zB-2dq7X:
12.8		 5y7zB-2dq7X:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 184
LYS A 186
GLU A 201
LEU A 238
GLY A 240
LEU A 290
ASP A 320
 None
 0.90A 5y7zB-2eu9A:
16.6		 5y7zB-2eu9A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
ALA A 184
LYS A 186
GLU A 201
LEU A 238
LEU A 290
ASP A 320
 None
 0.67A 5y7zB-2eu9A:
16.6		 5y7zB-2eu9A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
ASP A 169
 STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
STU  A 400 (-3.6A)
 0.45A 5y7zB-2gcdA:
18.0		 5y7zB-2gcdA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  55
ALA A  76
LYS A  78
GLY A 130
LEU A 177
CYH A 190
ASP A 191
 None
 0.93A 5y7zB-2hw6A:
11.7		 5y7zB-2hw6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  55
LYS A  78
GLU A  94
LEU A 122
GLY A 130
LEU A 177
CYH A 190
ASP A 191
 None
 1.12A 5y7zB-2hw6A:
11.7		 5y7zB-2hw6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
GLY A 505
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.71A 5y7zB-2j0jA:
23.4		 5y7zB-2j0jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
ALA A 614
GLU A 633
CYH A 666
GLY A 669
LEU A 785
ASP A 796
 None
 0.99A 5y7zB-2ogvA:
21.4		 5y7zB-2ogvA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 105
GLY A 109
LEU A 156
ASP A 167
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.69A 5y7zB-2phkA:
27.8		 5y7zB-2phkA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 724
ALA A 749
LEU A 794
LEU A 798
GLY A 802
LEU A 850
ASP A 861
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-4.1A)
 0.64A 5y7zB-2r4bA:
21.5		 5y7zB-2r4bA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 445
LYS A 447
GLU A 459
LEU A 491
GLY A 495
LEU A 542
ASP A 557
 None
 0.85A 5y7zB-2wntA:
14.4		 5y7zB-2wntA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
AMP  A1302 (-3.1A)
 0.76A 5y7zB-2yabA:
27.0		 5y7zB-2yabA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
ASP A 161
 4RB  A 401 ( 3.9A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
4RB  A 401 (-4.4A)
GOL  A 503 ( 3.1A)
 0.84A 5y7zB-3bqrA:
24.1		 5y7zB-3bqrA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
LEU A 174
ASP A 186
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.78A 5y7zB-3f2aA:
26.0		 5y7zB-3f2aA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
ALA A 859
GLU A 878
CYH A 912
GLY A 915
LEU A1029
CYH A1039
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
None
8ST  A2001 (-4.2A)
None
 0.92A 5y7zB-3hngA:
22.2		 5y7zB-3hngA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
ALA A 859
LYS A 861
GLU A 878
GLY A 915
LEU A1029
CYH A1039
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
None
8ST  A2001 (-4.2A)
None
 0.98A 5y7zB-3hngA:
22.2		 5y7zB-3hngA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 432
ALA A 453
LYS A 455
GLU A 468
LEU A 496
LEU A 500
ASP A 565
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.6A)
None
 0.73A 5y7zB-3kn5A:
14.1		 5y7zB-3kn5A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 432
ALA A 453
LYS A 455
GLU A 468
LEU A 500
LEU A 551
ASP A 565
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
ANP  A 400 (-4.6A)
ANP  A 400 (-4.7A)
None
 0.70A 5y7zB-3kn5A:
14.1		 5y7zB-3kn5A:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
ALA A 700
GLU A 715
LEU A 747
CYH A 748
LEU A 804
ASP A 828
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-4.2A)
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 0.86A 5y7zB-3lj0A:
17.2		 5y7zB-3lj0A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ALA A 229
LYS A 231
GLU A 244
LEU A 277
GLY A 285
LEU A 339
ASP A 350
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 (-3.9A)
 0.61A 5y7zB-3mdyA:
24.9		 5y7zB-3mdyA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
ALA A  70
LYS A  72
GLU A  91
GLY A 126
LEU A 173
ASP A 184
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
None
 0.69A 5y7zB-3mvjA:
17.7		 5y7zB-3mvjA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
ALA A 213
GLU A 234
LEU A 261
LEU A 265
GLY A 269
LEU A 318
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.83A 5y7zB-3nyoA:
24.7		 5y7zB-3nyoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
LEU A 265
GLY A 269
ASP A 329
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.0A)
 0.91A 5y7zB-3nyoA:
24.7		 5y7zB-3nyoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 726
ALA A 751
LYS A 753
LEU A 796
LEU A 800
GLY A 804
LEU A 852
ASP A 863
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
03Q  A   1 (-4.0A)
 0.81A 5y7zB-3pp0A:
22.3		 5y7zB-3pp0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
GLY A 631
LEU A 683
CYH A 693
ASP A 694
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
STU  A   1 (-3.5A)
 0.93A 5y7zB-3ppzA:
26.0		 5y7zB-3ppzA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
ALA A  84
LYS A  86
GLU A 115
GLY A 150
LEU A 197
ASP A 211
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 0.92A 5y7zB-3q5iA:
20.1		 5y7zB-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
ALA A 382
LYS A 384
GLU A 403
GLY A 439
LEU A 486
ASP A 497
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
07U  A   1 (-3.6A)
 0.70A 5y7zB-3txoA:
23.5		 5y7zB-3txoA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
None
 0.74A 5y7zB-3vidA:
21.6		 5y7zB-3vidA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.78A 5y7zB-3wzdA:
21.9		 5y7zB-3wzdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  31
LYS A  33
GLU A  50
LEU A  77
LEU A 132
CYH A 142
ASP A 143
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
NA  A 353 ( 2.5A)
 0.91A 5y7zB-3zduA:
23.8		 5y7zB-3zduA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
GLU A 885
CYH A 919
GLY A 922
LEU A1035
CYH A1045
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
 0.99A 5y7zB-4agdA:
22.0		 5y7zB-4agdA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 104
LYS A 106
GLU A 125
LEU A 152
GLY A 160
LEU A 208
ASP A 219
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
 0.77A 5y7zB-4aw2A:
24.8		 5y7zB-4aw2A:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
ALA A  43
LYS A  45
GLU A  64
GLY A  99
LEU A 146
ASP A 157
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
STU  A1550 (-3.6A)
 0.78A 5y7zB-4cfhA:
26.3		 5y7zB-4cfhA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 663
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
ASP A 800
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 3.3A)
 0.69A 5y7zB-4crsA:
26.5		 5y7zB-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  84
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.7A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
BX7  A 401 ( 3.7A)
 0.85A 5y7zB-4eutA:
20.6		 5y7zB-4eutA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  84
CYH A  89
GLY A  92
ASP A 157
 BX7  A 401 (-3.9A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
BX7  A 401 (-3.6A)
 0.72A 5y7zB-4euuA:
10.7		 5y7zB-4euuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
ALA A 400
GLU A 420
LEU A 446
GLY A 454
LEU A 501
ASP A 512
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.9A)
 0.78A 5y7zB-4f4pA:
17.3		 5y7zB-4f4pA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  50
LYS A  52
GLU A  71
LEU A 102
GLY A 106
LEU A 153
ASP A 164
 STU  A 401 (-3.2A)
None
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.65A 5y7zB-4fr4A:
24.6		 5y7zB-4fr4A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		8 ALA A 429
LYS A 431
GLU A 442
LEU A 473
GLY A 477
LEU A 524
CYH A 535
ASP A 536
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 3.7A)
0WB  A 701 (-3.1A)
 0.68A 5y7zB-4g3fA:
22.4		 5y7zB-4g3fA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
ALA A 880
LYS A 882
GLU A 898
LEU A 927
GLY A 935
LEU A 983
ASP A 994
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
IZA  A2001 ( 4.5A)
 0.80A 5y7zB-4gl9A:
24.7		 5y7zB-4gl9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
ALA A 853
LYS A 855
GLU A 871
GLY A 908
LEU A 956
ASP A 967
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.69A 5y7zB-4hviA:
24.8		 5y7zB-4hviA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
ALA A 853
LYS A 855
GLU A 871
LEU A 900
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.64A 5y7zB-4hviA:
24.8		 5y7zB-4hviA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
ALA A 427
GLU A 440
LEU A 471
GLY A 475
LEU A 522
CYH A 533
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
T28  A 701 (-3.7A)
T28  A 701 ( 3.4A)
 0.83A 5y7zB-4idtA:
22.6		 5y7zB-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 406
ALA A 427
LYS A 429
GLU A 440
LEU A 471
GLY A 475
CYH A 533
ASP A 534
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.7A)
T28  A 701 ( 3.4A)
 1.02A 5y7zB-4idtA:
22.6		 5y7zB-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		7 LEU A  15
ALA A  36
LYS A  38
LEU A  84
CYH A  89
GLY A  92
ASP A 157
 SU6  A 701 (-3.6A)
SU6  A 701 (-3.4A)
None
None
SU6  A 701 (-3.8A)
SU6  A 701 (-3.8A)
None
 0.61A 5y7zB-4jlcA:
18.1		 5y7zB-4jlcA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
ALA A  39
LYS A  41
LEU A  87
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.77A 5y7zB-4jxfA:
10.9		 5y7zB-4jxfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A  61
LYS A  63
GLU A  77
LEU A 102
GLY A 110
LEU A 163
CYH A 174
ASP A 175
 1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.2A)
 0.77A 5y7zB-4l52A:
22.6		 5y7zB-4l52A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  78
ALA A  99
GLU A 117
LEU A 144
LEU A 148
CYH A 149
GLY A 151
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
None
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 0.88A 5y7zB-4mvfA:
22.9		 5y7zB-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  78
ALA A  99
GLU A 117
LEU A 148
CYH A 149
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.85A 5y7zB-4mvfA:
22.9		 5y7zB-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  78
ALA A  99
LYS A 101
GLU A 117
LEU A 144
LEU A 148
GLY A 151
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.3A)
 0.89A 5y7zB-4mvfA:
22.9		 5y7zB-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 LEU A  78
ALA A  99
LYS A 101
GLU A 117
LEU A 148
GLY A 151
LEU A 199
ASP A 213
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
STU  A 601 (-4.3A)
 0.80A 5y7zB-4mvfA:
22.9		 5y7zB-4mvfA:
11.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  46
ALA A  67
GLU A  85
LEU A 121
LEU A 125
CYH A 126
GLY A 128
LEU A 180
CYH A 190
ASP A 191
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
None
 0.73A 5y7zB-4o38A:
35.0		 5y7zB-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLU A 132
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.61A 5y7zB-4o38A:
35.0		 5y7zB-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  46
ALA A  67
LYS A  69
GLU A  85
LEU A 121
LEU A 125
GLY A 128
ASP A 191
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
None
 0.86A 5y7zB-4o38A:
35.0		 5y7zB-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  46
ALA A  67
LYS A  69
GLU A  85
LEU A 125
GLY A 128
GLU A 132
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
None
 0.73A 5y7zB-4o38A:
35.0		 5y7zB-4o38A:
90.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
LEU A1030
ASP A1041
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
2TT  A1202 (-4.6A)
 0.74A 5y7zB-4oliA:
21.8		 5y7zB-4oliA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 627
ALA A 648
LYS A 650
GLU A 669
GLY A 707
LEU A 753
ASP A 764
 None
 0.95A 5y7zB-4otdA:
26.2		 5y7zB-4otdA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
GLU A 661
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
 0.63A 5y7zB-4rt7A:
22.5		 5y7zB-4rt7A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
CYH A 828
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
 0.79A 5y7zB-4rt7A:
22.5		 5y7zB-4rt7A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
ASP A 239
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.72A 5y7zB-4wb7A:
18.3		 5y7zB-4wb7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  52
ALA A  72
LYS A  74
GLU A  90
CYH A 129
GLY A 132
LEU A 183
CYH A 193
ASP A 194
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
ZN  A 403 ( 2.6A)
 0.65A 5y7zB-4wsqA:
33.9		 5y7zB-4wsqA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
CYH A 828
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
 0.70A 5y7zB-4xufA:
22.2		 5y7zB-4xufA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.80A 5y7zB-4xufA:
22.2		 5y7zB-4xufA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  34
ALA A  55
LYS A  57
GLU A  76
GLY A 111
LEU A 158
ASP A 172
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-4.7A)
ADP  A 506 ( 2.4A)
 0.90A 5y7zB-4ysjA:
18.7		 5y7zB-4ysjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
GLU A 290
LEU A 323
GLY A 331
LEU A 386
CYH A 396
ASP A 397
 STU  A 601 (-3.1A)
STU  A 601 ( 3.8A)
None
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
STU  A 601 (-3.2A)
STU  A 601 (-3.0A)
 0.92A 5y7zB-5e8yA:
24.6		 5y7zB-5e8yA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
LEU A1030
ASP A1041
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.85A 5y7zB-5f1zA:
23.3		 5y7zB-5f1zA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
ALA A 625
GLU A 644
CYH A 677
GLY A 680
LEU A 825
CYH A 835
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
 0.60A 5y7zB-5grnA:
23.2		 5y7zB-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
ALA A 625
LYS A 627
GLU A 644
CYH A 677
GLY A 680
CYH A 835
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.5A)
 0.71A 5y7zB-5grnA:
23.2		 5y7zB-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
ALA A  41
GLU A  61
LEU A  88
LEU A  92
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.75A 5y7zB-5hu3A:
19.6		 5y7zB-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
ALA A  41
GLU A  61
LEU A  92
GLY A  96
LEU A 143
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
MG  A 302 ( 3.3A)
 0.74A 5y7zB-5hu3A:
19.6		 5y7zB-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
LEU A  92
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.75A 5y7zB-5hu3A:
19.6		 5y7zB-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  92
GLY A  96
ASP A 157
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
MG  A 302 ( 3.3A)
 0.82A 5y7zB-5hu3A:
19.6		 5y7zB-5hu3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		9 LEU A  57
ALA A  77
LYS A  79
GLU A  95
CYH A 133
GLY A 136
LEU A 187
CYH A 197
ASP A 198
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
IDV  A 401 (-4.0A)
 0.64A 5y7zB-5i3oA:
33.2		 5y7zB-5i3oA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
ASP A 154
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 (-3.4A)
 0.44A 5y7zB-5j5tA:
13.7		 5y7zB-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 417
GLU A 436
LEU A 463
LEU A 467
GLY A 471
LEU A 518
ASP A 533
 GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.70A 5y7zB-5jznA:
26.1		 5y7zB-5jznA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 7 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
LEU A 174
ASP A 186
 None
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-4.8A)
None
 0.78A 5y7zB-5turA:
25.8		 5y7zB-5turA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 ALA A  38
LYS A  40
GLU A  57
CYH A  89
GLY A  92
LEU A 139
ASP A 150
 7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.85A 5y7zB-5tvtA:
25.4		 5y7zB-5tvtA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 116
ALA A 137
GLU A 157
LEU A 185
LEU A 189
CYH A 190
GLY A 191
ASP A 251
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
H8H  A 401 (-4.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
EDO  A 402 ( 2.9A)
 0.89A 5y7zB-5vcxA:
23.5		 5y7zB-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A 116
ALA A 137
LYS A 139
GLU A 157
LEU A 185
LEU A 189
CYH A 190
GLY A 191
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
H8H  A 401 (-4.3A)
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
 0.99A 5y7zB-5vcxA:
23.5		 5y7zB-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 8 ALA A  40
LYS A  42
GLU A  61
LEU A  93
LEU A  97
GLY A 100
LEU A 148
ASP A 159
 CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
CJJ  A 301 (-4.3A)
 1.02A 5y7zB-6b2qA:
24.8		 5y7zB-6b2qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
GLU A 925
LEU A 954
GLY A 962
LEU A1010
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
None
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
MG  A1203 (-1.8A)
 0.77A 5y7zB-6c7yA:
23.6		 5y7zB-6c7yA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
ALA A 906
LYS A 908
GLU A 925
LEU A 954
GLY A 962
ASP A1021
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
None
ADP  A1201 ( 4.1A)
MG  A1203 (-1.8A)
 0.75A 5y7zB-6c7yA:
23.6		 5y7zB-6c7yA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ALA A 192
LYS A 194
GLU A 236
LEU A 269
GLY A 273
LEU A 319
ASP A 330
 F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
F6J  A 501 ( 4.4A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
F6J  A 501 (-3.8A)
 0.67A 5y7zB-6cmjA:
25.3		 5y7zB-6cmjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 ALA U  42
LYS U  44
LEU U  89
CYH U  94
GLY U  97
LEU U 144
ASP U 157
 DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 (-3.6A)
 0.94A 5y7zB-6fdyU:
17.6		 5y7zB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
ALA U  42
LYS U  44
LEU U  89
CYH U  94
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
None
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.93A 5y7zB-6fdyU:
17.6		 5y7zB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 8 LEU A 169
ALA A 191
LYS A 193
GLU A 208
LEU A 245
GLY A 247
LEU A 297
ASP A 327
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.7A)
None
None
3NG  A 501 (-4.5A)
 0.94A 5y7zB-6fylA:
16.7		 5y7zB-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.87A 5y7zB-6fyoA:
25.2		 5y7zB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 LEU A 167
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.97A 5y7zB-6fyoA:
25.2		 5y7zB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 8 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
ASP A 325
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
None
3NG  A 501 (-4.3A)
 0.98A 5y7zB-6fyvA:
16.7		 5y7zB-6fyvA:
undetectable