SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y7Z_A_IREA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.65A 5y7zA-1opkA:
22.7		 5y7zA-1opkA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
VAL A 275
ALA A 288
LYS A 290
GLU A 305
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.65A 5y7zA-1opkA:
22.7		 5y7zA-1opkA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 ARG A 162
LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
 None
ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
 0.88A 5y7zA-1q8yA:
24.2		 5y7zA-1q8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 ARG A 162
LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
 None
ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
 0.88A 5y7zA-1q8yA:
24.2		 5y7zA-1q8yA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
 0.84A 5y7zA-1q8yA:
24.2		 5y7zA-1q8yA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 LEU A 164
VAL A 172
ALA A 185
LYS A 187
GLU A 202
GLY A 250
LEU A 301
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.7A)
 0.84A 5y7zA-1q8yA:
24.2		 5y7zA-1q8yA:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 None
 0.57A 5y7zA-1rjbA:
21.1		 5y7zA-1rjbA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 None
 0.57A 5y7zA-1rjbA:
21.1		 5y7zA-1rjbA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
CYH A 673
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.67A 5y7zA-1t46A:
23.1		 5y7zA-1t46A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 595
VAL A 603
ALA A 621
LYS A 623
GLU A 640
CYH A 673
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.67A 5y7zA-1t46A:
23.1		 5y7zA-1t46A:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.61A 5y7zA-1u59A:
23.9		 5y7zA-1u59A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
ALA A 367
LYS A 369
GLU A 386
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.61A 5y7zA-1u59A:
23.9		 5y7zA-1u59A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
 None
 0.61A 5y7zA-1u5qA:
25.7		 5y7zA-1u5qA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
 None
 0.61A 5y7zA-1u5qA:
25.7		 5y7zA-1u5qA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.64A 5y7zA-1zltA:
23.8		 5y7zA-1zltA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
GLU A  55
CYH A  87
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
None
HYM  A 400 (-4.2A)
None
HYM  A 400 (-4.5A)
 0.64A 5y7zA-1zltA:
23.8		 5y7zA-1zltA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.73A 5y7zA-2bujA:
31.0		 5y7zA-2bujA:
11.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
VAL A  34
ALA A  47
LYS A  49
GLU A  65
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.73A 5y7zA-2bujA:
31.0		 5y7zA-2bujA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.65A 5y7zA-2dq7X:
24.7		 5y7zA-2dq7X:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
LYS X  39
GLU X  54
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.65A 5y7zA-2dq7X:
24.7		 5y7zA-2dq7X:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
LEU A 238
LEU A 290
 None
 0.60A 5y7zA-2eu9A:
25.7		 5y7zA-2eu9A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 162
VAL A 170
ALA A 184
LYS A 186
GLU A 201
LEU A 238
LEU A 290
 None
 0.60A 5y7zA-2eu9A:
25.7		 5y7zA-2eu9A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.50A 5y7zA-2gcdA:
25.6		 5y7zA-2gcdA:
27.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 VAL A  42
ALA A  55
LYS A  57
GLU A  76
CYH A 108
GLY A 110
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-4.0A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.50A 5y7zA-2gcdA:
25.6		 5y7zA-2gcdA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 ARG A 426
VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
LEU A 553
 None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
 0.81A 5y7zA-2j0jA:
23.3		 5y7zA-2j0jA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 ARG A 426
VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
LEU A 553
 None
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-4.4A)
 0.81A 5y7zA-2j0jA:
23.3		 5y7zA-2j0jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.63A 5y7zA-2j0jA:
23.3		 5y7zA-2j0jA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
LEU A 501
CYH A 502
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
4ST  A1687 (-4.3A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.63A 5y7zA-2j0jA:
23.3		 5y7zA-2j0jA:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LEU A 501
CYH A 502
GLY A 505
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.4A)
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.41A 5y7zA-2jkmA:
22.8		 5y7zA-2jkmA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 436
ALA A 452
LEU A 501
CYH A 502
GLY A 505
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-4.4A)
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 0.41A 5y7zA-2jkmA:
22.8		 5y7zA-2jkmA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
GLY A 322
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.88A 5y7zA-2og8A:
21.8		 5y7zA-2og8A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
LYS A 273
GLU A 288
GLY A 322
LEU A 371
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.88A 5y7zA-2og8A:
21.8		 5y7zA-2og8A:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
GLU A 633
CYH A 666
GLY A 669
LEU A 785
 None
 0.66A 5y7zA-2ogvA:
21.4		 5y7zA-2ogvA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
GLU A 633
CYH A 666
GLY A 669
LEU A 785
 None
 0.66A 5y7zA-2ogvA:
21.4		 5y7zA-2ogvA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
 0.65A 5y7zA-2phkA:
27.7		 5y7zA-2phkA:
14.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 LEU A  25
VAL A  33
ALA A  46
LYS A  48
GLU A  73
LEU A 105
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
 0.65A 5y7zA-2phkA:
27.7		 5y7zA-2phkA:
30.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
VAL A 732
ALA A 749
LEU A 798
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.41A 5y7zA-2r4bA:
21.4		 5y7zA-2r4bA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
VAL A 732
ALA A 749
LEU A 798
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.41A 5y7zA-2r4bA:
21.4		 5y7zA-2r4bA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU C  55
VAL C  63
ALA C  76
LYS C  78
CYH C 132
GLU C 138
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
ANP  C   2 (-4.5A)
ANP  C   2 (-4.1A)
None
 0.92A 5y7zA-2wtkC:
25.8		 5y7zA-2wtkC:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU C  55
VAL C  63
ALA C  76
LYS C  78
CYH C 132
GLU C 138
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
ANP  C   2 (-4.5A)
ANP  C   2 (-4.1A)
None
 0.92A 5y7zA-2wtkC:
25.8		 5y7zA-2wtkC:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
CYH C 132
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
ANP  C   2 (-4.5A)
None
 0.99A 5y7zA-2wtkC:
25.8		 5y7zA-2wtkC:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU C  55
VAL C  63
ALA C  76
LYS C  78
GLU C  98
CYH C 132
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
ANP  C   2 (-4.5A)
None
 0.99A 5y7zA-2wtkC:
25.8		 5y7zA-2wtkC:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  38
ALA A  51
LYS A  53
GLU A  77
LEU A 109
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.88A 5y7zA-2y7jA:
28.0		 5y7zA-2y7jA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  38
ALA A  51
LYS A  53
GLU A  77
LEU A 109
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.88A 5y7zA-2y7jA:
28.0		 5y7zA-2y7jA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ARG A1000
LEU A1002
VAL A1010
ALA A1028
GLU A1047
LEU A1078
GLY A1082
 None
S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
S91  A   1 (-4.7A)
S91  A   1 (-3.3A)
 0.77A 5y7zA-2z8cA:
24.8		 5y7zA-2z8cA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ARG A1000
LEU A1002
VAL A1010
ALA A1028
GLU A1047
LEU A1078
GLY A1082
 None
S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
S91  A   1 (-3.2A)
None
S91  A   1 (-4.7A)
S91  A   1 (-3.3A)
 0.77A 5y7zA-2z8cA:
24.8		 5y7zA-2z8cA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  95
LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
 None
STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.86A 5y7zA-3a62A:
24.5		 5y7zA-3a62A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  95
LEU A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 143
GLY A 178
 None
STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 (-3.1A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.4A)
 0.86A 5y7zA-3a62A:
24.5		 5y7zA-3a62A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
 0.90A 5y7zA-3c4fA:
22.0		 5y7zA-3c4fA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
 0.90A 5y7zA-3c4fA:
22.0		 5y7zA-3c4fA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
VAL A 439
ALA A 455
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.81A 5y7zA-3fzpA:
22.3		 5y7zA-3fzpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
VAL A 439
ALA A 455
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-4.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.81A 5y7zA-3fzpA:
22.3		 5y7zA-3fzpA:
27.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
None
 0.77A 5y7zA-3hngA:
16.2		 5y7zA-3hngA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
VAL A 841
ALA A 859
LYS A 861
GLU A 878
CYH A 912
GLY A 915
LEU A1029
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-3.8A)
None
None
 0.77A 5y7zA-3hngA:
16.2		 5y7zA-3hngA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
VAL A 689
ALA A 700
GLU A 715
LEU A 747
CYH A 748
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-4.2A)
ADP  A2101 (-4.4A)
 0.78A 5y7zA-3lj0A:
24.4		 5y7zA-3lj0A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
VAL A 689
ALA A 700
GLU A 715
LEU A 747
CYH A 748
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-4.2A)
ADP  A2101 (-4.4A)
 0.78A 5y7zA-3lj0A:
24.4		 5y7zA-3lj0A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ARG A 556
VAL A 566
ALA A 579
LYS A 581
GLU A 596
GLY A 634
LEU A 684
 None
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
 0.87A 5y7zA-3lltA:
24.4		 5y7zA-3lltA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ARG A 556
VAL A 566
ALA A 579
LYS A 581
GLU A 596
GLY A 634
LEU A 684
 None
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
 0.87A 5y7zA-3lltA:
24.4		 5y7zA-3lltA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ARG A1003
LEU A1005
VAL A1013
ALA A1031
LYS A1033
LEU A1081
GLY A1085
 None
None
None
None
CCX  A   1 ( 3.7A)
None
None
 0.70A 5y7zA-3lw0A:
22.2		 5y7zA-3lw0A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ARG A1003
LEU A1005
VAL A1013
ALA A1031
LYS A1033
LEU A1081
GLY A1085
 None
None
None
None
CCX  A   1 ( 3.7A)
None
None
 0.70A 5y7zA-3lw0A:
22.2		 5y7zA-3lw0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.78A 5y7zA-3mvjA:
25.2		 5y7zA-3mvjA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  49
VAL A  57
ALA A  70
LYS A  72
GLU A  91
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
XFE  A 351 (-4.6A)
 0.78A 5y7zA-3mvjA:
25.2		 5y7zA-3mvjA:
26.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLU A 130
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
 0.76A 5y7zA-3nuuA:
26.8		 5y7zA-3nuuA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
LYS A 111
GLU A 130
GLY A 165
LEU A 212
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
 0.76A 5y7zA-3nuuA:
26.8		 5y7zA-3nuuA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 265
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.9A)
None
 0.83A 5y7zA-3nyoA:
24.7		 5y7zA-3nyoA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 192
VAL A 200
ALA A 213
LYS A 215
GLU A 234
LEU A 265
GLY A 269
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
AMP  A 577 ( 4.9A)
None
 0.83A 5y7zA-3nyoA:
24.7		 5y7zA-3nyoA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
VAL A 734
ALA A 751
LYS A 753
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.70A 5y7zA-3pp0A:
22.3		 5y7zA-3pp0A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
VAL A 734
ALA A 751
LYS A 753
LEU A 800
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.70A 5y7zA-3pp0A:
22.3		 5y7zA-3pp0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 ARG A  61
LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
GLY A 150
LEU A 197
 None
ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
 0.92A 5y7zA-3q5iA:
23.6		 5y7zA-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 ARG A  61
LEU A  63
VAL A  71
ALA A  84
LYS A  86
GLU A 115
GLY A 150
LEU A 197
 None
ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
None
ANP  A1634 (-4.4A)
 0.92A 5y7zA-3q5iA:
23.6		 5y7zA-3q5iA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
VAL A  71
ALA A  84
GLU A 115
GLY A 150
GLU A 154
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.4A)
 1.03A 5y7zA-3q5iA:
23.6		 5y7zA-3q5iA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  63
VAL A  71
ALA A  84
GLU A 115
GLY A 150
GLU A 154
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
None
ANP  A1634 (-4.4A)
 1.03A 5y7zA-3q5iA:
23.6		 5y7zA-3q5iA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		7 ARG A  31
LEU A  21
VAL A  29
ALA A  42
LYS A  44
GLU A  61
CYH A  99
 None
 0.93A 5y7zA-3qa8A:
18.9		 5y7zA-3qa8A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qa8 MGC80376 PROTEIN

(Xenopus laevis) 		PF00069
(Pkinase) 		7 ARG A  31
LEU A  21
VAL A  29
ALA A  42
LYS A  44
GLU A  61
CYH A  99
 None
 0.93A 5y7zA-3qa8A:
18.9		 5y7zA-3qa8A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.74A 5y7zA-3tt0A:
22.2		 5y7zA-3tt0A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
LYS A 514
GLU A 531
GLY A 567
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.74A 5y7zA-3tt0A:
22.2		 5y7zA-3tt0A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.70A 5y7zA-3txoA:
23.5		 5y7zA-3txoA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 361
VAL A 369
ALA A 382
LYS A 384
GLU A 403
GLY A 439
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
07U  A   1 ( 4.8A)
None
07U  A   1 (-4.3A)
 0.70A 5y7zA-3txoA:
23.5		 5y7zA-3txoA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ARG A 542
LEU A 544
VAL A 552
ALA A 570
LYS A 572
GLY A 623
LEU A 686
 None
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 1.03A 5y7zA-3v5qA:
21.2		 5y7zA-3v5qA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ARG A 542
LEU A 544
VAL A 552
ALA A 570
LYS A 572
GLY A 623
LEU A 686
 None
0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 1.03A 5y7zA-3v5qA:
21.2		 5y7zA-3v5qA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.74A 5y7zA-3vidA:
16.1		 5y7zA-3vidA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
4TT  A2001 (-4.8A)
 0.74A 5y7zA-3vidA:
16.1		 5y7zA-3vidA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.76A 5y7zA-3wzdA:
21.9		 5y7zA-3wzdA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
VAL A 848
ALA A 866
LYS A 868
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
 0.76A 5y7zA-3wzdA:
21.9		 5y7zA-3wzdA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2028
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.89A 5y7zA-3zbfA:
23.7		 5y7zA-3zbfA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
VAL A1959
ALA A1978
LYS A1980
LEU A2028
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.89A 5y7zA-3zbfA:
23.7		 5y7zA-3zbfA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
VAL A1959
LYS A1980
GLU A1997
LEU A2028
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
None
VGH  A3000 ( 4.7A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 1.01A 5y7zA-3zbfA:
23.7		 5y7zA-3zbfA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
VAL A1959
LYS A1980
GLU A1997
LEU A2028
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
None
VGH  A3000 ( 4.7A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 1.01A 5y7zA-3zbfA:
23.7		 5y7zA-3zbfA:
28.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  57
LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
 939  A1331 (-3.9A)
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
 0.89A 5y7zA-4a4lA:
28.4		 5y7zA-4a4lA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  57
LEU A  59
ALA A  80
LYS A  82
GLU A 101
LEU A 132
CYH A 133
 939  A1331 (-3.9A)
939  A1331 (-3.7A)
939  A1331 (-3.5A)
939  A1331 (-2.6A)
None
939  A1331 (-4.4A)
939  A1331 (-4.0A)
 0.89A 5y7zA-4a4lA:
28.4		 5y7zA-4a4lA:
29.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.70A 5y7zA-4agdA:
21.9		 5y7zA-4agdA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
ALA A 866
GLU A 885
CYH A 919
GLY A 922
LEU A1035
 B49  A2000 (-3.7A)
None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
B49  A2000 (-4.5A)
 0.70A 5y7zA-4agdA:
21.9		 5y7zA-4agdA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  66
LEU A  68
ALA A  89
LYS A  91
GLU A 110
LEU A 141
CYH A 142
 9ZP  A1333 (-3.3A)
9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.7A)
9ZP  A1333 (-4.1A)
 0.74A 5y7zA-4b6lA:
28.2		 5y7zA-4b6lA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  66
LEU A  68
ALA A  89
LYS A  91
GLU A 110
LEU A 141
CYH A 142
 9ZP  A1333 (-3.3A)
9ZP  A1333 (-3.9A)
9ZP  A1333 (-3.5A)
None
None
9ZP  A1333 (-4.7A)
9ZP  A1333 (-4.1A)
 0.74A 5y7zA-4b6lA:
28.2		 5y7zA-4b6lA:
28.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
VAL A  50
ALA A  63
GLU A  81
CYH A 113
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.71A 5y7zA-4bc6A:
23.2		 5y7zA-4bc6A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
VAL A  50
ALA A  63
GLU A  81
CYH A 113
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.71A 5y7zA-4bc6A:
23.2		 5y7zA-4bc6A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
VAL A  50
ALA A  63
LYS A  65
CYH A 113
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.84A 5y7zA-4bc6A:
23.2		 5y7zA-4bc6A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  42
VAL A  50
ALA A  63
LYS A  65
CYH A 113
GLY A 116
LEU A 164
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
XZN  A1317 (-4.7A)
 0.84A 5y7zA-4bc6A:
23.2		 5y7zA-4bc6A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
VAL A 254
ALA A 267
LYS A 269
GLU A 288
GLY A 324
LEU A 371
 None
 0.71A 5y7zA-4c0tA:
26.0		 5y7zA-4c0tA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
VAL A 254
ALA A 267
LYS A 269
GLU A 288
GLY A 324
LEU A 371
 None
 0.71A 5y7zA-4c0tA:
26.0		 5y7zA-4c0tA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLU A  64
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.79A 5y7zA-4cfhA:
26.2		 5y7zA-4cfhA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
ALA A  43
LYS A  45
GLU A  64
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.79A 5y7zA-4cfhA:
26.2		 5y7zA-4cfhA:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.68A 5y7zA-4crsA:
26.4		 5y7zA-4crsA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 663
VAL A 671
ALA A 684
LYS A 686
GLU A 705
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
 0.68A 5y7zA-4crsA:
26.4		 5y7zA-4crsA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.72A 5y7zA-4eutA:
20.5		 5y7zA-4eutA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
 0.72A 5y7zA-4eutA:
20.5		 5y7zA-4eutA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.63A 5y7zA-4euuA:
16.5		 5y7zA-4euuA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
ALA A  36
LYS A  38
GLU A  55
CYH A  89
GLY A  92
 BX7  A 401 (-3.9A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
 0.63A 5y7zA-4euuA:
16.5		 5y7zA-4euuA:
26.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
VAL A1130
ALA A1148
GLU A1167
LEU A1198
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.70A 5y7zA-4fodA:
22.4		 5y7zA-4fodA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
VAL A1130
ALA A1148
GLU A1167
LEU A1198
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.70A 5y7zA-4fodA:
22.4		 5y7zA-4fodA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  37
ALA A  50
LYS A  52
GLU A  71
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.72A 5y7zA-4fr4A:
24.6		 5y7zA-4fr4A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  37
ALA A  50
LYS A  52
GLU A  71
LEU A 102
GLY A 106
LEU A 153
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
STU  A 401 (-4.4A)
STU  A 401 ( 3.7A)
STU  A 401 (-4.7A)
 0.72A 5y7zA-4fr4A:
24.6		 5y7zA-4fr4A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A 416
ALA A 429
LYS A 431
GLU A 442
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.63A 5y7zA-4g3fA:
22.2		 5y7zA-4g3fA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A 416
ALA A 429
LYS A 431
GLU A 442
LEU A 473
GLY A 477
LEU A 524
 0WB  A 701 (-4.4A)
0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 (-3.2A)
0WB  A 701 (-4.3A)
0WB  A 701 ( 4.5A)
0WB  A 701 (-4.3A)
 0.63A 5y7zA-4g3fA:
22.2		 5y7zA-4g3fA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLU A 898
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.79A 5y7zA-4gl9A:
24.7		 5y7zA-4gl9A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
VAL A 863
ALA A 880
LYS A 882
GLU A 898
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.79A 5y7zA-4gl9A:
24.7		 5y7zA-4gl9A:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.70A 5y7zA-4hviA:
24.7		 5y7zA-4hviA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
VAL A 836
ALA A 853
LYS A 855
GLU A 871
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.70A 5y7zA-4hviA:
24.7		 5y7zA-4hviA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
LEU A 471
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 (-3.9A)
 0.84A 5y7zA-4idtA:
22.5		 5y7zA-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
VAL A 414
ALA A 427
LYS A 429
GLU A 440
LEU A 471
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 (-3.0A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 (-3.9A)
 0.84A 5y7zA-4idtA:
22.5		 5y7zA-4idtA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
VAL A 414
LYS A 429
GLU A 440
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.94A 5y7zA-4idtA:
22.5		 5y7zA-4idtA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 406
VAL A 414
LYS A 429
GLU A 440
LEU A 471
GLY A 475
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.8A)
T28  A 701 ( 3.0A)
T28  A 701 (-3.9A)
 0.94A 5y7zA-4idtA:
22.5		 5y7zA-4idtA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  28
LEU A  18
VAL A  26
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 ( 4.7A)
631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 1.03A 5y7zA-4jxfA:
18.6		 5y7zA-4jxfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  28
LEU A  18
VAL A  26
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 ( 4.7A)
631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 1.03A 5y7zA-4jxfA:
18.6		 5y7zA-4jxfA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
VAL A  26
ALA A  39
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.72A 5y7zA-4jxfA:
18.6		 5y7zA-4jxfA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  18
VAL A  26
ALA A  39
LYS A  41
CYH A  92
GLY A  95
LEU A 143
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
631  A 301 (-4.5A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
 0.72A 5y7zA-4jxfA:
18.6		 5y7zA-4jxfA:
28.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  33
VAL A  41
ALA A  54
LYS A  56
GLU A  70
CYH A 102
GLY A 103
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.0A)
None
 1.25A 5y7zA-4lg4A:
16.6		 5y7zA-4lg4A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  33
VAL A  41
ALA A  54
LYS A  56
GLU A  70
CYH A 102
GLY A 103
 GOL  A 404 ( 3.6A)
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
GOL  A 403 (-4.0A)
None
 1.25A 5y7zA-4lg4A:
16.6		 5y7zA-4lg4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
LEU A 148
CYH A 149
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.80A 5y7zA-4mvfA:
22.9		 5y7zA-4mvfA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 LEU A  78
VAL A  86
ALA A  99
LYS A 101
GLU A 117
LEU A 148
CYH A 149
GLY A 151
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
STU  A 601 (-4.3A)
STU  A 601 (-4.2A)
STU  A 601 (-3.4A)
STU  A 601 (-4.7A)
 0.80A 5y7zA-4mvfA:
22.9		 5y7zA-4mvfA:
22.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 ARG A  44
LEU A  46
VAL A  54
ALA A  67
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLN A 129
LEU A 180
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.52A 5y7zA-4o38A:
35.0		 5y7zA-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 ARG A  44
LEU A  46
VAL A  54
ALA A  67
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLN A 129
LEU A 180
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.52A 5y7zA-4o38A:
35.0		 5y7zA-4o38A:
97.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		11 ARG A  44
LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLU A 132
LEU A 180
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.75A 5y7zA-4o38A:
35.0		 5y7zA-4o38A:
90.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		11 ARG A  44
LEU A  46
VAL A  54
ALA A  67
LYS A  69
GLU A  85
LEU A 125
CYH A 126
GLY A 128
GLU A 132
LEU A 180
 None
SIN  A 401 ( 3.9A)
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 0.75A 5y7zA-4o38A:
35.0		 5y7zA-4o38A:
97.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ARG A 901
LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 2TT  A1202 ( 4.8A)
2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.97A 5y7zA-4oliA:
21.6		 5y7zA-4oliA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ARG A 901
LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 2TT  A1202 ( 4.8A)
2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.97A 5y7zA-4oliA:
21.6		 5y7zA-4oliA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 627
VAL A 635
ALA A 648
LYS A 650
GLU A 669
GLY A 707
LEU A 753
 None
 0.84A 5y7zA-4otdA:
7.3		 5y7zA-4otdA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 LEU A 627
VAL A 635
ALA A 648
LYS A 650
GLU A 669
GLY A 707
LEU A 753
 None
 0.84A 5y7zA-4otdA:
7.3		 5y7zA-4otdA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.72A 5y7zA-4rt7A:
15.9		 5y7zA-4rt7A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.72A 5y7zA-4rt7A:
15.9		 5y7zA-4rt7A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.79A 5y7zA-4wb7A:
25.4		 5y7zA-4wb7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 LEU A 104
VAL A 112
ALA A 125
LYS A 127
GLU A 146
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
ATP  A 501 (-4.5A)
 0.79A 5y7zA-4wb7A:
25.4		 5y7zA-4wb7A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 ARG A 191
LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 270
LEU A 321
 ANW  A 601 ( 4.9A)
ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.81A 5y7zA-4wboA:
25.5		 5y7zA-4wboA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 ARG A 191
LEU A 193
VAL A 201
ALA A 214
LYS A 216
GLU A 235
GLY A 270
LEU A 321
 ANW  A 601 ( 4.9A)
ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.81A 5y7zA-4wboA:
25.5		 5y7zA-4wboA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
VAL A  60
ALA A  72
LYS A  74
CYH A 129
GLY A 132
GLN A 133
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.6A)
 0.58A 5y7zA-4wsqA:
33.8		 5y7zA-4wsqA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
VAL A  60
ALA A  72
LYS A  74
CYH A 129
GLY A 132
GLN A 133
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-3.2A)
KSA  A 405 (-4.6A)
 0.58A 5y7zA-4wsqA:
33.8		 5y7zA-4wsqA:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
CYH A 129
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.59A 5y7zA-4wsqA:
33.8		 5y7zA-4wsqA:
25.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  52
VAL A  60
ALA A  72
LYS A  74
GLU A  90
CYH A 129
GLY A 132
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.6A)
 0.59A 5y7zA-4wsqA:
33.8		 5y7zA-4wsqA:
38.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.82A 5y7zA-4xcuA:
23.0		 5y7zA-4xcuA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 473
VAL A 481
ALA A 501
LYS A 503
GLU A 520
GLY A 556
LEU A 619
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.82A 5y7zA-4xcuA:
23.0		 5y7zA-4xcuA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.63A 5y7zA-4xufA:
22.1		 5y7zA-4xufA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
ALA A 642
LYS A 644
GLU A 661
CYH A 694
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.63A 5y7zA-4xufA:
22.1		 5y7zA-4xufA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 ARG A  32
LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
LEU A 158
 None
ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-4.7A)
 0.98A 5y7zA-4ysjA:
25.9		 5y7zA-4ysjA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		8 ARG A  32
LEU A  34
VAL A  42
ALA A  55
LYS A  57
GLU A  76
GLY A 111
LEU A 158
 None
ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 (-4.7A)
 0.98A 5y7zA-4ysjA:
25.9		 5y7zA-4ysjA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 577
VAL A 586
ALA A 597
GLU A 612
LEU A 644
CYH A 645
LEU A 695
 None
 0.77A 5y7zA-4z7gA:
21.3		 5y7zA-4z7gA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 577
VAL A 586
ALA A 597
GLU A 612
LEU A 644
CYH A 645
LEU A 695
 None
 0.77A 5y7zA-4z7gA:
21.3		 5y7zA-4z7gA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 577
VAL A 586
ALA A 597
LEU A 644
CYH A 645
GLU A 651
LEU A 695
 None
 0.85A 5y7zA-4z7gA:
21.3		 5y7zA-4z7gA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 577
VAL A 586
ALA A 597
LEU A 644
CYH A 645
GLU A 651
LEU A 695
 None
 0.85A 5y7zA-4z7gA:
21.3		 5y7zA-4z7gA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
GLU A 531
GLY A 567
GLU A 571
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 ( 3.7A)
38O  A1769 (-4.6A)
 0.99A 5y7zA-5a46A:
22.2		 5y7zA-5a46A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ALA A 512
GLU A 531
GLY A 567
GLU A 571
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
38O  A1769 (-3.4A)
38O  A1769 ( 3.7A)
38O  A1769 (-4.6A)
 0.99A 5y7zA-5a46A:
22.2		 5y7zA-5a46A:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ARG A 901
LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 5U3  A1200 ( 4.1A)
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 1.20A 5y7zA-5f1zA:
23.3		 5y7zA-5f1zA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ARG A 901
LEU A 903
VAL A 911
ALA A 928
LYS A 930
GLU A 947
GLY A 984
LEU A1030
 5U3  A1200 ( 4.1A)
5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 1.20A 5y7zA-5f1zA:
23.3		 5y7zA-5f1zA:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ARG A 597
LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
CYH A 677
GLY A 680
LEU A 825
 None
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.67A 5y7zA-5grnA:
23.1		 5y7zA-5grnA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ARG A 597
LEU A 599
VAL A 607
ALA A 625
LYS A 627
GLU A 644
CYH A 677
GLY A 680
LEU A 825
 None
748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.67A 5y7zA-5grnA:
23.1		 5y7zA-5grnA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.81A 5y7zA-5hu3A:
27.2		 5y7zA-5hu3A:
15.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
VAL A  28
ALA A  41
LYS A  43
GLU A  61
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.81A 5y7zA-5hu3A:
27.2		 5y7zA-5hu3A:
32.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
GLU A 100
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
 0.95A 5y7zA-5hu3A:
27.2		 5y7zA-5hu3A:
15.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		7 VAL A  28
ALA A  41
LYS A  43
GLU A  61
GLY A  96
GLU A 100
LEU A 143
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
None
ADP  A 301 (-4.7A)
 0.95A 5y7zA-5hu3A:
27.2		 5y7zA-5hu3A:
32.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
ALA A  77
GLU A  95
CYH A 133
GLY A 136
GLN A 137
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.7A)
IDV  A 401 (-4.4A)
 0.74A 5y7zA-5i3oA:
33.2		 5y7zA-5i3oA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
ALA A  77
GLU A  95
CYH A 133
GLY A 136
GLN A 137
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-3.7A)
IDV  A 401 (-4.4A)
 0.74A 5y7zA-5i3oA:
33.2		 5y7zA-5i3oA:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
CYH A 133
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.64A 5y7zA-5i3oA:
33.2		 5y7zA-5i3oA:
24.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  57
VAL A  65
ALA A  77
LYS A  79
GLU A  95
CYH A 133
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.64A 5y7zA-5i3oA:
33.2		 5y7zA-5i3oA:
40.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.49A 5y7zA-5j5tA:
14.0		 5y7zA-5j5tA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  43
LYS A  45
GLU A  61
CYH A  93
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.49A 5y7zA-5j5tA:
14.0		 5y7zA-5j5tA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A 394
VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
 None
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.68A 5y7zA-5jznA:
26.1		 5y7zA-5jznA:
14.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A 394
VAL A 404
ALA A 417
GLU A 436
LEU A 467
GLY A 471
LEU A 518
 None
GUI  A 701 (-4.4A)
GUI  A 701 ( 3.9A)
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.4A)
 0.68A 5y7zA-5jznA:
26.1		 5y7zA-5jznA:
32.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 136
GLY A 181
LEU A 232
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
W4A  A 716 (-3.8A)
None
 1.05A 5y7zA-5myvA:
23.9		 5y7zA-5myvA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 136
GLY A 181
LEU A 232
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
W4A  A 716 (-3.8A)
None
 1.05A 5y7zA-5myvA:
23.9		 5y7zA-5myvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
 0.44A 5y7zA-5vcxA:
23.4		 5y7zA-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 116
VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
 H8H  A 401 (-3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
 0.44A 5y7zA-5vcxA:
23.4		 5y7zA-5vcxA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
GLY A 191
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
 0.95A 5y7zA-5vcxA:
23.4		 5y7zA-5vcxA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 124
ALA A 137
LYS A 139
GLU A 157
LEU A 189
CYH A 190
GLY A 191
 H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
None
None
H8H  A 401 (-4.3A)
H8H  A 401 (-4.4A)
 0.95A 5y7zA-5vcxA:
23.4		 5y7zA-5vcxA:
26.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.83A 5y7zA-5vilA:
23.9		 5y7zA-5vilA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 LEU A 686
VAL A 694
ALA A 707
LYS A 709
GLU A 725
GLY A 760
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
None
9E1  A1001 (-3.4A)
9E1  A1001 (-4.5A)
 0.83A 5y7zA-5vilA:
23.9		 5y7zA-5vilA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 7 VAL A  27
ALA A  40
LYS A  42
GLU A  61
LEU A  97
GLY A 100
LEU A 148
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
 1.01A 5y7zA-6b2qA:
24.7		 5y7zA-6b2qA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2q SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		no annotation 7 VAL A  27
ALA A  40
LYS A  42
GLU A  61
LEU A  97
GLY A 100
LEU A 148
 CJJ  A 301 (-4.6A)
CJJ  A 301 (-3.5A)
CJJ  A 301 (-3.7A)
None
None
CJJ  A 301 (-4.2A)
CJJ  A 301 (-4.5A)
 1.01A 5y7zA-6b2qA:
24.7		 5y7zA-6b2qA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 ARG A 879
LEU A 881
VAL A 889
ALA A 906
GLU A 925
GLY A 962
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.69A 5y7zA-6c7yA:
23.6		 5y7zA-6c7yA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 ARG A 879
LEU A 881
VAL A 889
ALA A 906
GLU A 925
GLY A 962
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.69A 5y7zA-6c7yA:
23.6		 5y7zA-6c7yA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 ARG A 879
LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
GLY A 962
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
 0.72A 5y7zA-6c7yA:
23.6		 5y7zA-6c7yA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 ARG A 879
LEU A 881
VAL A 889
ALA A 906
LYS A 908
GLU A 925
GLY A 962
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
 0.72A 5y7zA-6c7yA:
23.6		 5y7zA-6c7yA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 VAL A 179
ALA A 192
LYS A 194
GLU A 236
LEU A 269
GLY A 273
LEU A 319
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
F6J  A 501 ( 4.4A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
 0.62A 5y7zA-6cmjA:
25.3		 5y7zA-6cmjA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 VAL A 179
ALA A 192
LYS A 194
GLU A 236
LEU A 269
GLY A 273
LEU A 319
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
F6J  A 501 ( 4.4A)
F6J  A 501 ( 3.7A)
F6J  A 501 (-4.5A)
 0.62A 5y7zA-6cmjA:
25.3		 5y7zA-6cmjA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 7 LEU U  20
VAL U  28
ALA U  42
LYS U  44
CYH U  94
GLY U  97
LEU U 144
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 (-4.2A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
 0.89A 5y7zA-6fdyU:
24.3		 5y7zA-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 8 LEU A 169
VAL A 177
ALA A 191
LYS A 193
GLU A 208
LEU A 245
GLY A 247
LEU A 297
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.7A)
None
None
 0.79A 5y7zA-6fylA:
25.3		 5y7zA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 LEU A 167
VAL A 175
ALA A 189
LYS A 191
LEU A 243
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 0.87A 5y7zA-6fyoA:
25.0		 5y7zA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 8 LEU A 167
VAL A 175
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
None
 0.93A 5y7zA-6fyvA:
25.2		 5y7zA-6fyvA:
undetectable