SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y7P_H_CHDH401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 LEU A 645
ILE A 688
PHE A 703
LEU A 658
ALA A 657
 None
 1.11A 5y7pH-1c4kA:
undetectable		 5y7pH-1c4kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 ILE A 202
LEU A 199
LEU A 243
ALA A 246
LEU A 248
 None
 1.20A 5y7pH-1e6zA:
0.0		 5y7pH-1e6zA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 LEU A 187
ILE A 756
ASN A 107
ALA A 964
LEU A 103
 None
 1.17A 5y7pH-1jqoA:
0.0		 5y7pH-1jqoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		5 ILE A  15
LEU A  19
PHE A  26
LEU A  34
ALA A  35
 None
 0.96A 5y7pH-1jztA:
undetectable		 5y7pH-1jztA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 TYR A 282
ILE A 294
LEU A 245
LEU A 164
ALA A 165
 None
 1.17A 5y7pH-1p43A:
0.0		 5y7pH-1p43A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		5 LEU A  68
ILE A 111
LEU A 112
PHE A  58
ALA A 348
 None
 1.19A 5y7pH-1p75A:
0.0		 5y7pH-1p75A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		5 LEU A  29
ILE A 352
LEU A 351
LEU A 298
ALA A 301
 None
 1.16A 5y7pH-1v5bA:
0.0		 5y7pH-1v5bA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 LEU A 293
TYR A 297
LEU A 208
ASN A 516
PHE A 195
 None
 1.24A 5y7pH-1w6jA:
0.0		 5y7pH-1w6jA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 LEU A 335
ILE A 516
LEU A 520
ALA A 462
LEU A 316
 None
 0.81A 5y7pH-1x9nA:
0.0		 5y7pH-1x9nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 357
ILE A  74
LEU A  68
ALA A  17
LEU A  25
 None
 1.14A 5y7pH-1yqdA:
undetectable		 5y7pH-1yqdA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		5 LEU A  55
ILE A  13
LEU A  17
LEU A  48
LEU A   5
 None
 1.18A 5y7pH-1zh4A:
undetectable		 5y7pH-1zh4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 248
PHE A 334
LEU A 380
ALA A 323
LEU A 326
 None
 1.21A 5y7pH-1zr6A:
undetectable		 5y7pH-1zr6A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 ILE A 170
LEU A 169
ASN A 139
ALA A 119
LEU A 138
 None
 1.26A 5y7pH-2bi3A:
undetectable		 5y7pH-2bi3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbb PUTATIVE HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PH0061

(Pyrococcus
horikoshii) 		PF13412
(HTH_24) 		5 ILE A 131
LEU A 128
PHE A 127
LEU A 141
LEU A 113
 None
 1.14A 5y7pH-2dbbA:
undetectable		 5y7pH-2dbbA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh3 TRANSCRIPTIONAL
REGULATOR

(Aquifex
aeolicus) 		PF00440
(TetR_N) 		5 ILE A 138
LEU A 142
PHE A 119
ASN A  68
LEU A  64
 None
 1.18A 5y7pH-2eh3A:
undetectable		 5y7pH-2eh3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		5 LEU A 241
ILE A 118
LEU A 123
LEU A 170
ALA A 168
 None
 1.22A 5y7pH-2g9bA:
undetectable		 5y7pH-2g9bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 LEU A 612
TYR A 594
ILE A 597
LEU A 197
ALA A 198
 None
None
None
None
FAD  A 700 (-3.3A)
 1.25A 5y7pH-2i0kA:
undetectable		 5y7pH-2i0kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		5 ILE A 120
LEU A  64
LEU A 103
ALA A 102
LEU A  71
 None
 1.07A 5y7pH-2i34A:
undetectable		 5y7pH-2i34A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922

(Mycobacterium
tuberculosis) 		PF00691
(OmpA)
PF04972
(BON) 		5 LEU A 153
PHE A 151
LEU A 106
ALA A 109
LEU A 113
 None
 1.26A 5y7pH-2l26A:
undetectable		 5y7pH-2l26A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 LEU A 380
ILE A 363
LEU A 425
ALA A 438
LEU A 442
 None
 1.23A 5y7pH-2nrrA:
undetectable		 5y7pH-2nrrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 LEU A 380
ILE A 363
LEU A 425
ALA A 438
LEU A 442
 None
 1.25A 5y7pH-2nrxA:
undetectable		 5y7pH-2nrxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 TYR A  77
ILE A 160
PHE A 192
ASN A 377
LEU A  94
 None
 1.26A 5y7pH-2nz9A:
undetectable		 5y7pH-2nz9A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		5 ILE A 118
LEU A  65
PHE A  68
ALA A  33
LEU A  73
 None
 1.24A 5y7pH-2owzA:
undetectable		 5y7pH-2owzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 LEU A 211
ILE A 134
PHE A 130
LEU A 158
ALA A 155
 None
 1.24A 5y7pH-2p2vA:
undetectable		 5y7pH-2p2vA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb4 ATP-DEPENDENT RNA
HELICASE DDX25

(Homo sapiens) 		PF00271
(Helicase_C) 		5 LEU A 456
LEU A 470
ASN A 412
LEU A 443
ALA A 444
 None
 1.00A 5y7pH-2rb4A:
undetectable		 5y7pH-2rb4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A 726
TYR A 641
ILE A 783
PHE A 761
LEU A 670
 None
 1.17A 5y7pH-2vsqA:
undetectable		 5y7pH-2vsqA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF13599
(Pentapeptide_4) 		5 TYR A  34
ILE A  37
LEU A  39
ALA A  27
LEU A  47
 None
 1.15A 5y7pH-2w7zA:
undetectable		 5y7pH-2w7zA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 421
LEU A 356
PHE A 358
LEU A 385
LEU A 406
 None
 1.17A 5y7pH-2z63A:
undetectable		 5y7pH-2z63A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bordetella
parapertussis) 		PF00440
(TetR_N) 		5 LEU A 139
ILE A 132
LEU A 131
LEU A  94
LEU A  78
 None
 1.24A 5y7pH-3ccyA:
undetectable		 5y7pH-3ccyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		5 LEU A 511
ILE A 434
LEU A 437
ASN A 262
LEU A 293
 None
 1.18A 5y7pH-3do6A:
undetectable		 5y7pH-3do6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 LEU A 348
LEU A 359
ASN A  62
PHE A 430
ALA A  56
 None
 1.15A 5y7pH-3fcrA:
undetectable		 5y7pH-3fcrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN

(Agrobacterium
fabrum) 		PF03466
(LysR_substrate) 		5 LEU A 222
TYR A 186
LEU A 265
LEU A 124
ALA A 121
 EDO  A 322 (-4.4A)
None
None
None
None
 1.19A 5y7pH-3fd3A:
undetectable		 5y7pH-3fd3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnb ACYLAMINOACYL
PEPTIDASE SMU_737

(Streptococcus
mutans) 		PF12146
(Hydrolase_4) 		5 LEU A 100
ILE A  32
ASN A  63
LEU A  69
ALA A  66
 None
 1.11A 5y7pH-3fnbA:
undetectable		 5y7pH-3fnbA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 307
ILE A 247
LEU A 250
PHE A 223
LEU A 228
 None
 1.20A 5y7pH-3fxiA:
undetectable		 5y7pH-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 421
LEU A 356
PHE A 358
LEU A 385
LEU A 406
 None
 1.21A 5y7pH-3fxiA:
undetectable		 5y7pH-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		5 LEU A  58
TYR A  26
LEU A 228
ALA A 146
LEU A 295
 None
 1.16A 5y7pH-3g5tA:
undetectable		 5y7pH-3g5tA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0n UNCHARACTERIZED
PROTEIN DUF1470

(Jannaschia sp.
CCS1) 		PF07336
(ABATE)
PF11706
(zf-CGNR) 		5 LEU A  65
LEU A  11
LEU A  76
ALA A  72
LEU A  88
 None
 1.11A 5y7pH-3h0nA:
undetectable		 5y7pH-3h0nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A 549
ASN A 735
LEU A 601
ALA A 602
LEU A 698
 None
 1.13A 5y7pH-3hhdA:
undetectable		 5y7pH-3hhdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		5 LEU P 127
ILE P 141
LEU P 140
LEU P 190
LEU P 164
 None
 1.18A 5y7pH-3j9tP:
undetectable		 5y7pH-3j9tP:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		5 LEU A 128
ILE A  84
LEU A  81
LEU A 166
ALA A 167
 None
 1.16A 5y7pH-3ksrA:
undetectable		 5y7pH-3ksrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		5 ILE X 697
PHE X 711
LEU X 677
ALA X 678
LEU X 467
 None
 1.26A 5y7pH-3l3fX:
undetectable		 5y7pH-3l3fX:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 5 LEU F 153
LEU F  49
PHE F  85
PHE F  47
ALA F 177
 None
 1.13A 5y7pH-3n2nF:
undetectable		 5y7pH-3n2nF:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		5 ILE A  80
PHE A  25
LEU A 102
ALA A 243
LEU A 137
 None
None
None
FMT  A 500 (-3.6A)
None
 0.99A 5y7pH-3nnmA:
undetectable		 5y7pH-3nnmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		5 LEU A 429
TYR A 433
ILE A 435
PHE A 442
LEU A 477
 None
 1.23A 5y7pH-3odmA:
undetectable		 5y7pH-3odmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ILE A 641
LEU A 620
LEU A 632
ALA A 663
LEU A 651
 None
 1.16A 5y7pH-3ogrA:
undetectable		 5y7pH-3ogrA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pst PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		5 ILE A 697
PHE A 711
LEU A 677
ALA A 678
LEU A 467
 None
 1.26A 5y7pH-3pstA:
undetectable		 5y7pH-3pstA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 LEU A 166
ILE A 453
PHE A 157
PHE A 466
LEU A 503
 None
None
None
GOL  A 560 (-4.6A)
None
 1.18A 5y7pH-3rcnA:
undetectable		 5y7pH-3rcnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		5 LEU A 225
ILE A  87
PHE A  91
LEU A 288
ALA A 286
 None
 1.18A 5y7pH-3wwxA:
undetectable		 5y7pH-3wwxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 LEU A 747
ILE A 864
LEU A 861
PHE A 858
LEU A 842
 None
 1.22A 5y7pH-3x1lA:
undetectable		 5y7pH-3x1lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 LEU A 354
ILE A 217
LEU A 220
LEU A 389
LEU A 195
 None
 1.24A 5y7pH-4b56A:
undetectable		 5y7pH-4b56A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 LEU A 363
ILE A  62
LEU A  53
LEU A 319
ALA A 349
 None
 1.24A 5y7pH-4d9iA:
undetectable		 5y7pH-4d9iA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 109
ILE A 259
LEU A 253
ASN A  85
ALA A  83
 None
 1.26A 5y7pH-4emwA:
undetectable		 5y7pH-4emwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3y DIHYDRODIPICOLINATE
REDUCTASE

(Burkholderia
thailandensis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 LEU A  35
LEU A  83
LEU A  90
ALA A  89
LEU A  96
 None
 1.05A 5y7pH-4f3yA:
undetectable		 5y7pH-4f3yA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 LEU A 350
ILE A 380
LEU A 378
LEU A 416
LEU A 278
 None
 1.25A 5y7pH-4fqdA:
undetectable		 5y7pH-4fqdA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 TYR A 132
PHE A 136
ASN A 149
PHE A  67
ALA A  16
 None
 1.21A 5y7pH-4ha4A:
undetectable		 5y7pH-4ha4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 ILE C 907
LEU C 911
LEU C 875
ALA C 873
LEU C 877
 None
 1.26A 5y7pH-4hb4C:
undetectable		 5y7pH-4hb4C:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivn TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		PF01380
(SIS)
PF01418
(HTH_6) 		5 ILE A 120
LEU A 117
ASN A 209
LEU A 245
ALA A 243
 None
 1.18A 5y7pH-4ivnA:
undetectable		 5y7pH-4ivnA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		5 ILE A 166
LEU A 162
ASN A  53
LEU A 155
ALA A 154
 ILE  A 166 ( 0.7A)
LEU  A 162 ( 0.6A)
ASN  A  53 ( 0.6A)
LEU  A 155 ( 0.5A)
ALA  A 154 ( 0.0A)
 1.00A 5y7pH-4jbeA:
undetectable		 5y7pH-4jbeA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1363
ILE A1335
LEU A1353
LEU A1432
LEU A1383
 None
 0.99A 5y7pH-4ll8A:
undetectable		 5y7pH-4ll8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 680
ILE A 576
PHE A 581
LEU A 541
LEU A 562
 None
 0.92A 5y7pH-4m7eA:
undetectable		 5y7pH-4m7eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		5 LEU A 335
PHE A 239
LEU A 314
ALA A 312
LEU A 352
 None
 0.94A 5y7pH-4nz0A:
undetectable		 5y7pH-4nz0A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU B 284
ILE B 128
LEU B 129
LEU B 275
ALA B 278
 None
 1.24A 5y7pH-4o27B:
undetectable		 5y7pH-4o27B:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 TYR A 717
ILE A 693
LEU A 667
PHE A 645
LEU A 672
 None
 1.19A 5y7pH-4oj5A:
undetectable		 5y7pH-4oj5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		5 LEU A 103
ILE A  81
LEU A  80
LEU A 168
LEU A 182
 None
 1.25A 5y7pH-4okrA:
undetectable		 5y7pH-4okrA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 LEU A 242
ILE A 491
PHE A 429
ASN A 240
LEU A 480
 None
 1.21A 5y7pH-4p3iA:
undetectable		 5y7pH-4p3iA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		5 LEU A  90
ILE A 154
LEU A 342
ALA A 339
LEU A 335
 None
None
None
None
GSH  A 401 (-4.8A)
 1.20A 5y7pH-4pyrA:
undetectable		 5y7pH-4pyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6t GLYCOSYL HYDROLASE,
FAMILY 18

(Pseudomonas
protegens) 		PF00704
(Glyco_hydro_18) 		5 LEU A 193
LEU A 119
PHE A 162
LEU A 146
LEU A 201
 None
 1.22A 5y7pH-4q6tA:
undetectable		 5y7pH-4q6tA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 LEU A 371
TYR A 400
ILE A 403
LEU A 313
ALA A 309
 None
 1.21A 5y7pH-4r7uA:
undetectable		 5y7pH-4r7uA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw3 PHOSPHOLIPASE D
LISICTOX-ALPHAIA1BII

(Loxosceles
intermedia) 		no annotation 5 ILE A 134
LEU A  93
PHE A  91
LEU A 114
ALA A 111
 None
 1.23A 5y7pH-4rw3A:
undetectable		 5y7pH-4rw3A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 ILE A 837
LEU A 838
ASN A 924
ALA A 920
LEU A 921
 None
 1.11A 5y7pH-4uvkA:
undetectable		 5y7pH-4uvkA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw9 BETA-PHOSPHOGLUCOMUT
ASE

(Pyrococcus sp.
ST04) 		PF13419
(HAD_2) 		5 ILE A 225
LEU A 224
ASN A 115
PHE A 208
LEU A 216
 None
 1.25A 5y7pH-4uw9A:
undetectable		 5y7pH-4uw9A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 LEU A 747
ILE A 864
LEU A 861
PHE A 858
LEU A 842
 None
 1.23A 5y7pH-4w8yA:
undetectable		 5y7pH-4w8yA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 156
ILE A 126
LEU A 102
PHE A  40
LEU A  91
 None
 1.18A 5y7pH-4z61A:
undetectable		 5y7pH-4z61A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 5 TYR D 277
LEU D 166
ASN D 127
LEU D 159
LEU D 220
 None
 1.20A 5y7pH-4zhsD:
undetectable		 5y7pH-4zhsD:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zms RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 ILE A 159
ASN A 185
LEU A 181
ALA A 189
LEU A 178
 None
 1.24A 5y7pH-4zmsA:
undetectable		 5y7pH-4zmsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqi D-ALANINE--D-ALANINE
LIGASE

(Yersinia pestis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A  30
LEU A  50
LEU A  62
ALA A  61
LEU A   9
 None
 1.21A 5y7pH-4zqiA:
undetectable		 5y7pH-4zqiA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG

(Thermococcus
kodakarensis) 		PF10609
(ParA) 		5 LEU B 154
LEU B  35
LEU B  42
ALA B  41
LEU B  53
 None
ACP  B 301 (-3.9A)
None
None
None
 1.16A 5y7pH-5auoB:
undetectable		 5y7pH-5auoB:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  57
TYR A  35
ILE A  27
PHE A  81
ASN A  60
 None
 1.05A 5y7pH-5b3rA:
undetectable		 5y7pH-5b3rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE

(Pseudomonas
putida) 		PF02585
(PIG-L) 		5 LEU A   9
LEU A  99
LEU A 129
ALA A 130
LEU A  41
 None
 1.17A 5y7pH-5cgzA:
undetectable		 5y7pH-5cgzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B

(Oryza sativa) 		PF03083
(MtN3_slv) 		5 LEU A 143
PHE A  83
LEU A  21
ALA A  20
LEU A  23
 None
 1.18A 5y7pH-5cthA:
undetectable		 5y7pH-5cthA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 TYR B 657
ILE B 660
LEU B 664
LEU B 550
ALA B 551
 None
 0.92A 5y7pH-5dlqB:
undetectable		 5y7pH-5dlqB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF13354
(Beta-lactamase2) 		5 LEU A  87
ILE A  76
LEU A  73
LEU A 120
ALA A 119
 None
 1.14A 5y7pH-5eoeA:
undetectable		 5y7pH-5eoeA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		5 ILE A 325
LEU A 328
PHE A 331
LEU A 228
ALA A 229
 None
 1.13A 5y7pH-5fsgA:
undetectable		 5y7pH-5fsgA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		6 ILE A  58
LEU A  63
ASN A  79
PHE A  99
LEU A 135
LEU A 138
 None
 1.05A 5y7pH-5gs7A:
48.7		 5y7pH-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		6 TYR A  24
ILE A  58
LEU A  63
ASN A  79
LEU A 135
LEU A 138
 None
 1.11A 5y7pH-5gs7A:
48.7		 5y7pH-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		7 LEU A  18
LEU A  63
ASN A  79
PHE A 100
LEU A 136
ALA A 137
LEU A 139
 OCS  A   2 ( 3.9A)
None
OCS  A   2 ( 3.7A)
None
None
None
None
 1.37A 5y7pH-5hkeA:
52.2		 5y7pH-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		8 LEU A  18
TYR A  24
ILE A  56
LEU A  63
PHE A 100
LEU A 136
ALA A 137
LEU A 139
 OCS  A   2 ( 3.9A)
None
None
None
None
None
None
None
 1.44A 5y7pH-5hkeA:
52.2		 5y7pH-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		9 LEU A  20
TYR A  24
ILE A  56
LEU A  63
PHE A  65
PHE A 100
LEU A 136
ALA A 137
LEU A 139
 None
 0.60A 5y7pH-5hkeA:
52.2		 5y7pH-5hkeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		5 TYR A 117
ILE A 121
PHE A 138
ALA A 107
LEU A 105
 ADP  A 803 (-4.6A)
None
None
None
None
 1.04A 5y7pH-5hmpA:
undetectable		 5y7pH-5hmpA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		5 ILE A 182
LEU A 377
LEU A 431
ALA A 432
LEU A 474
 None
 1.15A 5y7pH-5iheA:
undetectable		 5y7pH-5iheA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 LEU A 396
LEU A 349
LEU A 337
ALA A 343
LEU A 444
 None
 1.24A 5y7pH-5ikpA:
undetectable		 5y7pH-5ikpA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixu UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF07978
(NIPSNAP) 		5 LEU A  33
TYR A  28
ILE A  88
PHE A  84
LEU A  75
 None
 0.87A 5y7pH-5ixuA:
undetectable		 5y7pH-5ixuA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 LEU B 429
ILE B 368
LEU B 369
LEU B 398
ALA B 385
 None
 1.21A 5y7pH-5k1cB:
undetectable		 5y7pH-5k1cB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 ILE H 102
LEU H 259
PHE H 257
ALA H  41
LEU H  38
 None
 1.18A 5y7pH-5lp7H:
undetectable		 5y7pH-5lp7H:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nri D-ALANINE--D-ALANINE
LIGASE

(Burkholderia
pseudomallei) 		no annotation 5 LEU A  37
LEU A  57
LEU A  69
ALA A  68
LEU A  16
 None
 1.17A 5y7pH-5nriA:
undetectable		 5y7pH-5nriA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A  73
ILE A 126
LEU A  15
ALA A  18
LEU A  30
 None
 1.20A 5y7pH-6amnA:
undetectable		 5y7pH-6amnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 5 ILE A  68
LEU A  60
PHE A  64
LEU A 124
ALA A 122
 None
 1.16A 5y7pH-6b92A:
undetectable		 5y7pH-6b92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans) 		no annotation 5 LEU A 293
ILE A 235
LEU A 184
PHE A 162
ALA A 276
 None
 1.17A 5y7pH-6cw5A:
undetectable		 5y7pH-6cw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 5 LEU A 252
ILE A 238
LEU A 209
LEU A 216
ALA A 221
 None
 1.18A 5y7pH-6etiA:
undetectable		 5y7pH-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8l -

(-) 		no annotation 5 ILE G 438
LEU G 441
LEU G 448
ALA G 447
LEU G 412
 None
 1.14A 5y7pH-6f8lG:
undetectable		 5y7pH-6f8lG:
undetectable