SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y7P_G_CHDG401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6a HYDROGEN
PEROXIDE-INDUCIBLE
GENES ACTIVATOR


(Escherichia
coli)
PF03466
(LysR_substrate)
5 LEU A 120
ILE A 110
LEU A 124
ALA A 143
LEU A 270
None
1.24A 5y7pG-1i6aA:
undetectable
5y7pG-1i6aA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2


(Solanum
lycopersicum)
PF00155
(Aminotran_1_2)
5 ILE A 102
LEU A 276
ALA A 242
LEU A 332
GLU A 255
None
1.15A 5y7pG-1iayA:
0.0
5y7pG-1iayA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Zea mays)
PF00311
(PEPcase)
5 LEU A 187
ILE A 756
ASN A 107
ALA A 964
LEU A 103
None
1.14A 5y7pG-1jqoA:
0.0
5y7pG-1jqoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE


(Bos taurus)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
5 LEU A 343
ILE A 355
LEU A 448
ALA A 433
LEU A 402
None
1.24A 5y7pG-1lamA:
0.0
5y7pG-1lamA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgv TROPOMODULIN TMD-1

(Caenorhabditis
elegans)
no annotation 5 LEU A 309
ILE A 258
LEU A 272
ALA A 328
GLU A 308
None
1.20A 5y7pG-1pgvA:
undetectable
5y7pG-1pgvA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg)
5 LEU A 136
ILE A 355
PHE A  52
ALA A 186
LEU A 182
None
None
None
None
GLA  A 400 ( 4.3A)
1.27A 5y7pG-1pieA:
0.0
5y7pG-1pieA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn5 NACHT-, LRR- AND
PYD-CONTAINING
PROTEIN 2


(Homo sapiens)
PF02758
(PYRIN)
5 LEU A  74
LEU A  85
LEU A 127
ALA A 128
LEU A 115
None
1.22A 5y7pG-1pn5A:
undetectable
5y7pG-1pn5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz1 GENERAL STRESS
PROTEIN 69


(Bacillus
subtilis)
PF00248
(Aldo_ket_red)
5 LEU A 290
ILE A 261
LEU A 206
ALA A 277
LEU A 269
None
None
NAP  A 500 (-3.9A)
None
None
1.06A 5y7pG-1pz1A:
0.0
5y7pG-1pz1A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrz PLASMINOGEN

(Homo sapiens)
PF00089
(Trypsin)
5 ILE A 593
LEU A 649
LEU A 605
ALA A 602
GLU A 724
None
1.20A 5y7pG-1qrzA:
0.0
5y7pG-1qrzA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9l GLYCINE
BETAINE-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF04069
(OpuAC)
5 TYR A  96
ILE A 111
LEU A 150
ALA A 145
LEU A 213
None
1.17A 5y7pG-1r9lA:
0.0
5y7pG-1r9lA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rty YVQK PROTEIN

(Bacillus
subtilis)
PF01923
(Cob_adeno_trans)
5 LEU A  93
ILE A  40
PHE A  68
LEU A  85
GLU A  94
None
1.09A 5y7pG-1rtyA:
undetectable
5y7pG-1rtyA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9h PROBABLE GTPASE ENGC

(Bacillus
subtilis)
PF03193
(RsgA_GTPase)
PF16745
(RsgA_N)
5 TYR A 137
ILE A 113
PHE A 100
LEU A 101
ALA A  95
None
None
None
None
CA  A 415 ( 4.4A)
1.20A 5y7pG-1t9hA:
undetectable
5y7pG-1t9hA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE


(Escherichia
coli)
PF03710
(GlnE)
PF08335
(GlnD_UR_UTase)
5 ILE A 329
LEU A 362
LEU A 359
ALA A 355
GLU A 113
None
1.22A 5y7pG-1v4aA:
undetectable
5y7pG-1v4aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE


(Thermotoga
maritima)
PF00348
(polyprenyl_synt)
5 ILE A  20
PHE A  27
LEU A  72
LEU A 111
ALA A 108
None
1.06A 5y7pG-1wl1A:
undetectable
5y7pG-1wl1A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9j SEC1 FAMILY DOMAIN
CONTAINING PROTEIN 1


(Rattus
norvegicus)
PF00995
(Sec1)
5 TYR A 145
ILE A  10
ASN A 112
ALA A  17
LEU A  18
None
1.23A 5y7pG-1y9jA:
undetectable
5y7pG-1y9jA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE


(Populus
tremuloides)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 357
ILE A  74
LEU A  68
ALA A  17
LEU A  25
None
1.13A 5y7pG-1yqdA:
undetectable
5y7pG-1yqdA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 ILE A 205
LEU A 165
LEU A 187
ALA A 189
GLU A 196
None
1.02A 5y7pG-2d0iA:
undetectable
5y7pG-2d0iA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0i DEHYDROGENASE

(Pyrococcus
horikoshii)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 197
LEU A 165
LEU A 187
ALA A 189
GLU A 196
None
1.17A 5y7pG-2d0iA:
undetectable
5y7pG-2d0iA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E


(Methanothermobacter
thermautotrophicus)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD)
5 LEU C 142
ILE C  14
ASN C 107
LEU C 208
GLU C 143
None
1.00A 5y7pG-2d6fC:
undetectable
5y7pG-2d6fC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E


(Methanothermobacter
thermautotrophicus)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD)
5 LEU C 142
ILE C 185
LEU C 208
LEU C 443
GLU C 143
None
1.22A 5y7pG-2d6fC:
undetectable
5y7pG-2d6fC:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddx BETA-1,3-XYLANASE

(Vibrio sp. AX-4)
no annotation 5 LEU A  64
ASN A  23
LEU A  29
ALA A  26
GLU A  63
None
1.26A 5y7pG-2ddxA:
undetectable
5y7pG-2ddxA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj0 THIOREDOXIN-RELATED
TRANSMEMBRANE
PROTEIN 2


(Homo sapiens)
PF00085
(Thioredoxin)
5 TYR A  48
ASN A  61
LEU A  91
LEU A  93
LEU A  60
None
1.25A 5y7pG-2dj0A:
undetectable
5y7pG-2dj0A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU X  66
ILE X 136
LEU X 131
LEU X 151
ALA X 152
None
1.08A 5y7pG-2dq7X:
undetectable
5y7pG-2dq7X:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dut HETEROCHROMATIN-ASSO
CIATED PROTEIN MENT


(Gallus gallus)
PF00079
(Serpin)
5 LEU A 102
ILE A 193
LEU A  39
ALA A  40
LEU A  41
None
1.14A 5y7pG-2dutA:
undetectable
5y7pG-2dutA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 LEU A 300
ILE A 370
LEU A 365
LEU A 385
ALA A 386
None
1.02A 5y7pG-2hk5A:
undetectable
5y7pG-2hk5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum)
PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind)
5 LEU A 612
TYR A 594
ILE A 597
LEU A 254
LEU A 197
None
1.04A 5y7pG-2i0kA:
undetectable
5y7pG-2i0kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum)
PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind)
5 TYR A 594
ILE A 597
LEU A 254
LEU A 197
ALA A 198
None
None
None
None
FAD  A 700 (-3.3A)
1.17A 5y7pG-2i0kA:
undetectable
5y7pG-2i0kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6u ORNITHINE
CARBAMOYLTRANSFERASE


(Mycobacterium
tuberculosis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 ILE A 120
LEU A 300
LEU A  22
ALA A  23
GLU A 288
None
1.25A 5y7pG-2i6uA:
undetectable
5y7pG-2i6uA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 LEU A 605
TYR A 603
ASN A 609
LEU A 625
GLU A 636
None
None
MD1  A1987 (-3.7A)
None
MD1  A1987 (-2.9A)
1.17A 5y7pG-2ivfA:
undetectable
5y7pG-2ivfA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjw GAF FAMILY PROTEIN

(Mycolicibacterium
smegmatis)
PF01590
(GAF)
5 LEU A 323
ILE A 294
LEU A 254
LEU A 245
ALA A 244
None
1.25A 5y7pG-2vjwA:
undetectable
5y7pG-2vjwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN


(Thermus
thermophilus)
PF14589
(NrfD_2)
5 LEU C  38
TYR C  49
LEU C 163
LEU C 176
ALA C 172
None
1.20A 5y7pG-2vpwC:
undetectable
5y7pG-2vpwC:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x27 OUTER MEMBRANE
PROTEIN OPRG


(Pseudomonas
aeruginosa)
PF03922
(OmpW)
5 ILE X  11
ASN X 108
PHE X 155
LEU X 164
ALA X 110
None
None
C8E  X1224 ( 4.7A)
None
None
1.19A 5y7pG-2x27X:
undetectable
5y7pG-2x27X:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A 163
ILE A 233
LEU A 228
LEU A 250
ALA A 251
None
None
None
EDO  A1378 ( 4.6A)
None
0.96A 5y7pG-2x4fA:
undetectable
5y7pG-2x4fA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yl2 ACETYL-COA
CARBOXYLASE 1


(Homo sapiens)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
6 ILE A 425
ASN A 571
LEU A 631
LEU A 618
ALA A 614
GLU A 606
None
1.26A 5y7pG-2yl2A:
undetectable
5y7pG-2yl2A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE


(Homo sapiens)
PF00378
(ECH_1)
5 LEU A 107
ILE A 165
LEU A 184
ALA A 139
GLU A  76
None
1.16A 5y7pG-2zqqA:
undetectable
5y7pG-2zqqA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22


(Homo sapiens)
PF00225
(Kinesin)
5 LEU A 272
ILE A 215
LEU A 155
LEU A 157
LEU A 115
None
None
UNX  A 708 ( 4.9A)
None
None
1.22A 5y7pG-3bfnA:
undetectable
5y7pG-3bfnA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glb HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CATM


(Acinetobacter
sp. ADP1)
PF03466
(LysR_substrate)
5 ILE A 207
LEU A 164
ALA A 247
LEU A 231
GLU A 125
None
0.95A 5y7pG-3glbA:
undetectable
5y7pG-3glbA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A 549
ASN A 735
LEU A 601
ALA A 602
LEU A 698
None
1.07A 5y7pG-3hhdA:
undetectable
5y7pG-3hhdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr8 PROTEIN RECA

(Thermotoga
maritima)
PF00154
(RecA)
5 LEU A 128
ILE A  63
PHE A 219
LEU A 215
GLU A 125
None
1.22A 5y7pG-3hr8A:
undetectable
5y7pG-3hr8A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
5 ASN A 827
LEU A 766
LEU A 833
ALA A 832
GLU A 500
None
1.13A 5y7pG-3ihyA:
undetectable
5y7pG-3ihyA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5w TRYPTOPHANYL-TRNA
SYNTHETASE


(Campylobacter
jejuni)
PF00579
(tRNA-synt_1b)
5 LEU A 207
ILE A 214
PHE A 233
LEU A 240
GLU A 204
None
1.27A 5y7pG-3m5wA:
undetectable
5y7pG-3m5wA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne8 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE


(Bartonella
henselae)
PF01520
(Amidase_3)
5 LEU A 378
ILE A 364
ASN A 371
LEU A 334
GLU A 375
None
1.21A 5y7pG-3ne8A:
undetectable
5y7pG-3ne8A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qiv SHORT-CHAIN
DEHYDROGENASE OR
3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 ILE A 182
LEU A 219
ALA A  24
LEU A  25
GLU A 230
None
1.22A 5y7pG-3qivA:
undetectable
5y7pG-3qivA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 LIGHT CHAIN


(Cricetulus
migratorius)
PF07654
(C1-set)
PF07686
(V-set)
5 TYR L  86
ILE L  21
LEU L  46
LEU L  54
GLU L  79
None
1.20A 5y7pG-3r08L:
undetectable
5y7pG-3r08L:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9w GTPASE ERA

(Aquifex
aeolicus)
PF01926
(MMR_HSR1)
PF07650
(KH_2)
5 LEU A 279
LEU A 193
ALA A 194
LEU A 267
GLU A 278
None
1.17A 5y7pG-3r9wA:
undetectable
5y7pG-3r9wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum)
PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C)
5 LEU A 277
ILE A 257
LEU A 241
LEU A 267
LEU A 314
None
1.26A 5y7pG-3t8lA:
undetectable
5y7pG-3t8lA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Aliivibrio
fischeri)
PF00275
(EPSP_synthase)
5 LEU A 371
TYR A 400
ILE A 403
LEU A 313
ALA A 309
None
1.21A 5y7pG-3vcyA:
undetectable
5y7pG-3vcyA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8


(Saccharomyces
cerevisiae)
PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
5 LEU B1066
ILE B1078
LEU B 999
ALA B1110
LEU B1107
None
1.20A 5y7pG-3zefB:
undetectable
5y7pG-3zefB:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zxu MCM21
CTF19


(Kluyveromyces
lactis;
Kluyveromyces
lactis)
PF09496
(CENP-O)
no annotation
5 LEU A 139
ILE A 180
LEU A 169
LEU B  80
GLU A 140
None
1.15A 5y7pG-3zxuA:
undetectable
5y7pG-3zxuA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1


(Pseudomonas
virus phi6)
no annotation 5 LEU A 333
ILE A 322
LEU A 284
LEU A 288
ALA A 289
None
1.20A 5y7pG-4btgA:
undetectable
5y7pG-4btgA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czb NA(+)/H(+)
ANTIPORTER 1


(Methanocaldococcus
jannaschii)
PF00999
(Na_H_Exchanger)
5 ILE A 209
LEU A 221
LEU A 223
ALA A 226
LEU A  71
None
1.21A 5y7pG-4czbA:
undetectable
5y7pG-4czbA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3


(Ustilago maydis)
PF00069
(Pkinase)
5 ILE A 163
LEU A 150
LEU A 316
ALA A 315
LEU A 297
None
1.22A 5y7pG-4e7wA:
undetectable
5y7pG-4e7wA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep6 CYTOCHROME P450-LIKE
PROTEIN XPLA


(Rhodococcus
rhodochrous)
PF00067
(p450)
5 PHE A 388
LEU A 363
ALA A 364
LEU A 306
GLU A 353
HEM  A 601 (-4.2A)
None
None
None
None
1.17A 5y7pG-4ep6A:
undetectable
5y7pG-4ep6A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evf GIARDIN SUBUNIT
ALPHA-1


(Giardia
intestinalis)
PF00191
(Annexin)
5 LEU A  58
ILE A 287
PHE A  25
ALA A  14
LEU A  11
None
1.21A 5y7pG-4evfA:
undetectable
5y7pG-4evfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 143
LEU A 203
ALA A 127
LEU A 135
GLU A 144
None
1.14A 5y7pG-4gisA:
undetectable
5y7pG-4gisA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes)
PF13416
(SBP_bac_8)
5 TYR A 344
PHE A 349
LEU A 206
ALA A 202
LEU A 184
PG4  A 503 (-3.7A)
None
None
None
None
1.17A 5y7pG-4gl0A:
undetectable
5y7pG-4gl0A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gve NUCLEOPROTEIN

(Tacaribe
mammarenavirus)
PF17290
(Arena_ncap_C)
5 LEU A 467
ILE A 456
LEU A 399
LEU A 533
ALA A 532
None
1.26A 5y7pG-4gveA:
undetectable
5y7pG-4gveA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E


(Mycobacterium
tuberculosis)
PF04452
(Methyltrans_RNA)
5 LEU A 212
PHE A 106
LEU A 107
LEU A  85
ALA A  84
None
1.21A 5y7pG-4l69A:
undetectable
5y7pG-4l69A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae)
PF01843
(DIL)
5 LEU A1363
ILE A1335
LEU A1312
LEU A1432
LEU A1383
None
0.83A 5y7pG-4ll8A:
undetectable
5y7pG-4ll8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf6 GLUTATHIONE
S-TRANSFERASE DOMAIN


(Paraburkholderia
graminis)
PF00043
(GST_C)
PF02798
(GST_N)
5 ILE A 126
PHE A 208
LEU A 164
ALA A 214
GLU A  40
None
1.21A 5y7pG-4mf6A:
undetectable
5y7pG-4mf6A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn6 SENSOR PROTEIN
KINASE WALK


(Staphylococcus
aureus)
PF13426
(PAS_9)
5 LEU A 314
ILE A 277
ALA A 342
LEU A 334
GLU A 317
None
1.23A 5y7pG-4mn6A:
undetectable
5y7pG-4mn6A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER


(Chromobacterium
violaceum)
PF04348
(LppC)
5 LEU A  90
ILE A 154
LEU A 342
ALA A 339
LEU A 335
None
None
None
None
GSH  A 401 (-4.8A)
1.15A 5y7pG-4pyrA:
undetectable
5y7pG-4pyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE


(Vibrio cholerae)
PF00275
(EPSP_synthase)
5 LEU A 371
TYR A 400
ILE A 403
LEU A 313
ALA A 309
None
1.20A 5y7pG-4r7uA:
undetectable
5y7pG-4r7uA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR


(Enterococcus
faecium)
PF13377
(Peripla_BP_3)
5 LEU A 262
LEU A 223
LEU A 250
ALA A 249
GLU A 263
None
1.26A 5y7pG-4rk1A:
undetectable
5y7pG-4rk1A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wuv 2-HYDROXYCYCLOHEXANE
CARBOXYL-COA
DEHYDROGENASE


(Haemophilus
influenzae)
PF00106
(adh_short)
5 LEU A 253
ILE A 260
LEU A  13
ALA A   9
GLU A 250
None
1.16A 5y7pG-4wuvA:
undetectable
5y7pG-4wuvA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN


(Brucella ovis)
PF00497
(SBP_bac_3)
5 TYR A 174
LEU A 181
LEU A 186
ALA A 187
GLU A 161
None
1.26A 5y7pG-4z9nA:
undetectable
5y7pG-4z9nA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbz URACIL-DNA
GLYCOSYLASE


(Sulfurisphaera
tokodaii)
PF03167
(UDG)
5 LEU A  73
ILE A 117
LEU A 178
LEU A  63
GLU A  74
GOL  A 203 ( 4.7A)
None
None
None
None
1.08A 5y7pG-4zbzA:
undetectable
5y7pG-4zbzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zms RESPONSE REGULATOR

(Streptococcus
pneumoniae)
PF00072
(Response_reg)
PF00196
(GerE)
5 ILE A 159
ASN A 185
LEU A 181
ALA A 189
LEU A 178
None
1.25A 5y7pG-4zmsA:
undetectable
5y7pG-4zmsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn7 MALTODEXTRIN
GLUCOSIDASE


(Escherichia
coli)
PF00128
(Alpha-amylase)
5 ILE A 409
LEU A 455
LEU A 463
ALA A 466
LEU A 470
None
1.12A 5y7pG-5bn7A:
undetectable
5y7pG-5bn7A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B


(Oryza sativa)
PF03083
(MtN3_slv)
5 LEU A 143
PHE A  83
LEU A  21
ALA A  20
LEU A  23
None
1.27A 5y7pG-5cthA:
undetectable
5y7pG-5cthA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dji 3'-PHOSPHOADENOSINE
5'-PHOSPHATE
PHOSPHATASE


(Mycobacterium
tuberculosis)
PF00459
(Inositol_P)
5 ILE A 111
ASN A 238
LEU A  61
ALA A  69
GLU A 123
None
1.19A 5y7pG-5djiA:
undetectable
5y7pG-5djiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do8 LMO0184 PROTEIN

(Listeria
monocytogenes)
no annotation 5 ILE B 520
PHE B 491
LEU B 484
LEU B 300
ALA B 489
None
1.14A 5y7pG-5do8B:
undetectable
5y7pG-5do8B:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE


(Rhodobacter
sphaeroides)
PF03170
(BcsB)
5 LEU B 200
ILE B 270
LEU B 298
ALA B 229
LEU B 226
None
1.07A 5y7pG-5ej1B:
undetectable
5y7pG-5ej1B:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3


(Homo sapiens)
PF00171
(Aldedh)
5 ILE A 232
ASN A 199
LEU A 187
ALA A 194
LEU A 195
None
1.18A 5y7pG-5fhzA:
undetectable
5y7pG-5fhzA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1


(Arabidopsis
thaliana)
PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8)
5 LEU A 231
ILE A 215
ASN A 277
LEU A 224
LEU A 274
None
1.21A 5y7pG-5gr8A:
undetectable
5y7pG-5gr8A:
19.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE


(Enterococcus
faecalis)
PF02275
(CBAH)
6 ASN A  79
PHE A  99
LEU A 133
LEU A 135
LEU A 138
GLU A 269
None
0.69A 5y7pG-5gs7A:
48.6
5y7pG-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE


(Enterococcus
faecalis)
PF02275
(CBAH)
6 ILE A  58
ASN A  79
PHE A  99
LEU A 135
LEU A 138
GLU A 269
None
1.05A 5y7pG-5gs7A:
48.6
5y7pG-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE


(Enterococcus
faecalis)
PF02275
(CBAH)
6 TYR A  24
ILE A  58
ASN A  79
LEU A 135
LEU A 138
GLU A 269
None
1.00A 5y7pG-5gs7A:
48.6
5y7pG-5gs7A:
53.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3


(Saccharomyces
cerevisiae)
PF13513
(HEAT_EZ)
5 ILE A 727
LEU A 754
ALA A 750
LEU A 706
GLU A 742
None
1.25A 5y7pG-5h2vA:
undetectable
5y7pG-5h2vA:
14.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius)
PF02275
(CBAH)
7 ASN A  79
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
GLU A 270
OCS  A   2 ( 3.7A)
None
None
None
None
None
None
0.76A 5y7pG-5hkeA:
52.5
5y7pG-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius)
PF02275
(CBAH)
7 LEU A  18
ASN A  79
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
OCS  A   2 ( 3.7A)
None
None
None
None
None
1.35A 5y7pG-5hkeA:
52.5
5y7pG-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius)
PF02275
(CBAH)
8 LEU A  18
TYR A  24
ILE A  56
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
OCS  A   2 ( 3.9A)
None
None
None
None
None
None
None
1.37A 5y7pG-5hkeA:
52.5
5y7pG-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius)
PF02275
(CBAH)
9 LEU A  20
TYR A  24
ILE A  56
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
GLU A 270
None
0.51A 5y7pG-5hkeA:
52.5
5y7pG-5hkeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hop LMO0182 PROTEIN

(Listeria
monocytogenes)
no annotation 5 PHE A 234
LEU A 196
ALA A 192
LEU A 211
GLU A 218
None
1.25A 5y7pG-5hopA:
undetectable
5y7pG-5hopA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikz OXALATE BIOSYNTHETIC
COMPONENT 1


(Burkholderia
thailandensis)
PF05853
(BKACE)
5 ASN A  91
LEU A  35
ALA A  30
LEU A  88
GLU A  63
None
1.09A 5y7pG-5ikzA:
undetectable
5y7pG-5ikzA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE


(Staphylococcus
aureus)
no annotation 5 LEU A 356
ILE A 289
LEU A 320
LEU A 367
ALA A 363
None
1.10A 5y7pG-5jnmA:
undetectable
5y7pG-5jnmA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus)
PF08715
(Viral_protease)
5 LEU A  68
TYR A  72
ILE A 130
LEU A 151
LEU A  86
None
None
None
ACT  A 405 ( 4.5A)
None
1.21A 5y7pG-5ko3A:
undetectable
5y7pG-5ko3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE


(Streptomyces
arenae)
PF00067
(p450)
5 ILE A 272
LEU A 248
LEU A 371
LEU A 140
GLU A 117
None
1.25A 5y7pG-5l1tA:
undetectable
5y7pG-5l1tA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ode GLL2934 PROTEIN

(Gloeobacter
violaceus)
no annotation 5 LEU A  57
ILE A  71
LEU A  28
LEU A 284
ALA A 297
FAD  A 400 (-4.6A)
None
None
None
FAD  A 400 ( 3.5A)
1.27A 5y7pG-5odeA:
undetectable
5y7pG-5odeA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyr BACTERIOPHYTOCHROME

(Xanthomonas
campestris)
no annotation 5 LEU A 187
TYR A 190
ILE A 178
LEU A 256
GLU A 186
None
BLA  A 900 (-4.4A)
None
None
None
1.23A 5y7pG-5uyrA:
undetectable
5y7pG-5uyrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE


(Clostridium
perfringens)
PF00478
(IMPDH)
5 ILE A 434
ASN A  19
LEU A 349
ALA A 453
GLU A  22
None
1.06A 5y7pG-5uzeA:
undetectable
5y7pG-5uzeA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5va8 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Paraburkholderia
phymatum)
PF13561
(adh_short_C2)
5 LEU A  44
ILE A  66
LEU A  11
LEU A  27
ALA A  24
None
NAP  A 301 (-4.2A)
None
None
None
1.12A 5y7pG-5va8A:
undetectable
5y7pG-5va8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjc PROTEIN MINI
SPINDLES


(Drosophila
melanogaster)
no annotation 5 LEU A1218
TYR A1254
ILE A1211
LEU A1236
LEU A1231
None
1.22A 5y7pG-5vjcA:
undetectable
5y7pG-5vjcA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdi UBIQUITIN-ASSOCIATED
AND SH3
DOMAIN-CONTAINING
PROTEIN A


(Homo sapiens)
PF00300
(His_Phos_1)
5 PHE A 447
LEU A 484
ALA A 483
LEU A 526
GLU A 556
None
1.25A 5y7pG-5wdiA:
undetectable
5y7pG-5wdiA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0y TRANSCRIPTION
REGULATORY PROTEIN
SNF2


(Saccharomyces
cerevisiae)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC)
5 LEU O 683
ILE O 945
ASN O 784
LEU O 987
LEU O 781
None
1.17A 5y7pG-5x0yO:
undetectable
5y7pG-5x0yO:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT


(Thermococcus
kodakarensis)
no annotation 5 LEU A 189
ILE A 101
LEU A 283
ALA A 287
LEU A 312
None
1.25A 5y7pG-5yy0A:
undetectable
5y7pG-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk6 HENDRA VIRUS MATRIX
PROTEIN


(Hendra
henipavirus)
no annotation 5 LEU A 194
ILE A 278
LEU A 206
LEU A 327
ALA A 203
None
None
None
CME  A 255 ( 4.7A)
None
1.14A 5y7pG-6bk6A:
undetectable
5y7pG-6bk6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4n PSEUDOPALINE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
no annotation 5 LEU A 121
LEU A 108
ALA A 135
LEU A 102
GLU A 210
None
1.26A 5y7pG-6c4nA:
undetectable
5y7pG-6c4nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d5i PHOSPHOENOLPYRUVATE
CARBOXYKINASE (ATP)


(Escherichia
coli)
no annotation 5 LEU A 486
ILE A 459
PHE A 359
LEU A 374
GLU A 485
None
1.25A 5y7pG-6d5iA:
undetectable
5y7pG-6d5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9atc ASPARTATE
TRANSCARBAMOYLASE


(Escherichia
coli)
PF01948
(PyrI)
PF02748
(PyrI_C)
5 ILE B  21
ASN B 153
LEU B  74
LEU B  76
LEU B 151
None
1.23A 5y7pG-9atcB:
undetectable
5y7pG-9atcB:
18.94