SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y7P_E_CHDE401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpz CYCLIN-DEPENDENT
KINASE INHIBITOR 3

(Homo sapiens) 		PF05706
(CDKN3) 		4 LEU A 156
LEU A 154
ALA A 151
LEU A  32
 None
 0.84A 5y7pE-1fpzA:
0.0		 5y7pE-1fpzA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7e ENDOPLASMIC
RETICULUM PROTEIN
ERP29

(Rattus
norvegicus) 		PF07912
(ERp29_N) 		4 ILE A 141
LEU A  57
LEU A  39
ALA A  38
 None
 0.77A 5y7pE-1g7eA:
0.0		 5y7pE-1g7eA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		4 TYR A 327
ILE A 399
ASN A 280
LEU A 385
 None
 0.76A 5y7pE-1hxjA:
undetectable		 5y7pE-1hxjA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		4 ILE A 209
PHE A 178
LEU A 158
ALA A 291
 None
 0.86A 5y7pE-1i2oA:
0.0		 5y7pE-1i2oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		4 ILE A 123
LEU A 135
LEU A 276
ALA A 275
 None
 0.87A 5y7pE-1iuqA:
0.0		 5y7pE-1iuqA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		4 ILE A  15
PHE A  26
LEU A  34
ALA A  35
 None
 0.86A 5y7pE-1jztA:
0.0		 5y7pE-1jztA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6s L-ALLO-THREONINE
ALDOLASE

(Thermotoga
maritima) 		PF01212
(Beta_elim_lyase) 		4 ILE A 328
LEU A 306
ALA A 307
LEU A 300
 None
 0.72A 5y7pE-1m6sA:
undetectable		 5y7pE-1m6sA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 TYR A 215
ASN A 342
LEU A 232
ALA A 231
 None
 0.79A 5y7pE-1mdwA:
0.0		 5y7pE-1mdwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		4 ILE A 171
ASN A  18
LEU A  41
ALA A  10
 None
FAD  A 501 (-3.6A)
None
None
 0.80A 5y7pE-1qbgA:
0.0		 5y7pE-1qbgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrd QUINONE-REDUCTASE

(Rattus rattus) 		PF02525
(Flavodoxin_2) 		4 ILE A 171
ASN A  18
LEU A  41
ALA A  10
 None
FAD  A 274 (-3.8A)
None
None
 0.76A 5y7pE-1qrdA:
undetectable		 5y7pE-1qrdA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 301
LEU A 362
ALA A 363
LEU A 364
 None
 0.66A 5y7pE-1r2jA:
undetectable		 5y7pE-1r2jA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u08 HYPOTHETICAL
AMINOTRANSFERASE
YBDL

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 LEU A 322
LEU A  35
ALA A 349
LEU A 341
 None
 0.85A 5y7pE-1u08A:
undetectable		 5y7pE-1u08A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5x PHOSPHORIBOSYLANTHRA
NILATE ISOMERASE

(Thermus
thermophilus) 		PF00697
(PRAI) 		4 ILE A   5
ASN A 159
LEU A 189
LEU A 160
 None
 0.81A 5y7pE-1v5xA:
undetectable		 5y7pE-1v5xA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		4 ILE A  62
LEU A 149
ALA A 130
LEU A 132
 None
 0.86A 5y7pE-1yniA:
undetectable		 5y7pE-1yniA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		4 LEU A 249
LEU A 258
ALA A 259
LEU A 208
 None
 0.85A 5y7pE-2avdA:
undetectable		 5y7pE-2avdA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfw GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1) 		4 ILE A 289
LEU A 325
LEU A 351
ALA A 353
 None
 0.86A 5y7pE-2bfwA:
undetectable		 5y7pE-2bfwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE

(Homo sapiens) 		PF01648
(ACPS) 		4 ILE A  92
LEU A 104
ALA A 130
LEU A 128
 None
 0.79A 5y7pE-2cg5A:
undetectable		 5y7pE-2cg5A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		4 ILE A  61
LEU A 355
LEU A 353
ALA A 350
 None
 0.83A 5y7pE-2dhtA:
undetectable		 5y7pE-2dhtA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fc9 NCL PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  78
LEU A  20
LEU A  70
ALA A  69
 None
 0.81A 5y7pE-2fc9A:
undetectable		 5y7pE-2fc9A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		4 ILE A 345
ASN A 328
LEU A 334
ALA A 331
 None
 0.86A 5y7pE-2hp3A:
undetectable		 5y7pE-2hp3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 107
LEU A 161
ALA A 324
LEU A 328
 None
 0.85A 5y7pE-2hw6A:
undetectable		 5y7pE-2hw6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 ILE A 273
PHE A 279
ALA A 186
LEU A 282
 None
 0.83A 5y7pE-2irmA:
undetectable		 5y7pE-2irmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mph PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3

(Homo sapiens) 		PF00254
(FKBP_C) 		4 PHE A  28
LEU A  66
ALA A  62
LEU A  43
 None
 0.85A 5y7pE-2mphA:
undetectable		 5y7pE-2mphA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4v PORIN P

(Pseudomonas
aeruginosa) 		PF07396
(Porin_O_P) 		4 ILE A 219
ASN A 172
LEU A 292
LEU A 254
 None
 0.80A 5y7pE-2o4vA:
undetectable		 5y7pE-2o4vA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozu HISTONE
ACETYLTRANSFERASE
MYST3

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 TYR A 653
ILE A 649
LEU A 618
LEU A 544
 None
ACO  A 850 (-3.6A)
None
None
 0.87A 5y7pE-2ozuA:
undetectable		 5y7pE-2ozuA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 ILE A 159
PHE A 126
ALA A 148
LEU A 150
 None
 0.72A 5y7pE-2qzpA:
undetectable		 5y7pE-2qzpA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rk0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN

(Frankia sp.
EAN1pec) 		PF00903
(Glyoxalase) 		4 ILE A  53
LEU A  76
ALA A 124
LEU A  89
 None
 0.80A 5y7pE-2rk0A:
undetectable		 5y7pE-2rk0A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xuz IRON-UPTAKE
SYSTEM-BINDING
PROTEIN

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 ILE A 121
LEU A 140
LEU A  53
ALA A  50
 None
 0.74A 5y7pE-2xuzA:
undetectable		 5y7pE-2xuzA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 4 TYR A  57
ILE A  59
LEU A 675
LEU A  49
 None
 0.86A 5y7pE-2yr5A:
undetectable		 5y7pE-2yr5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		4 TYR A 333
ILE A 405
ASN A 286
LEU A 391
 None
 0.78A 5y7pE-3aivA:
undetectable		 5y7pE-3aivA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 PHE A 366
LEU A 365
LEU A 471
ALA A 472
 None
 0.87A 5y7pE-3cdiA:
undetectable		 5y7pE-3cdiA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch7 6-PHOSPHOGLUCONOLACT
ONASE

(Leishmania
braziliensis) 		PF01182
(Glucosamine_iso) 		4 LEU A 161
LEU A 218
ALA A 219
LEU A 257
 None
 0.70A 5y7pE-3ch7A:
undetectable		 5y7pE-3ch7A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		4 ILE A 214
LEU A 190
LEU A 188
ALA A 170
 None
 0.86A 5y7pE-3ddnA:
undetectable		 5y7pE-3ddnA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlt ESTERASE D

(Lactobacillus
rhamnosus) 		PF12146
(Hydrolase_4) 		4 ASN A  32
PHE A  91
LEU A  38
ALA A  35
 None
 0.79A 5y7pE-3dltA:
undetectable		 5y7pE-3dltA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 LEU A 158
LEU A 217
ALA A 218
LEU A 255
 None
 0.60A 5y7pE-3e7fA:
undetectable		 5y7pE-3e7fA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 ILE A 383
ASN A 467
LEU A 349
LEU A 473
ALA A 470
 None
 1.18A 5y7pE-3eo7A:
undetectable		 5y7pE-3eo7A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 PHE A 343
LEU A 342
LEU A 448
ALA A 449
 None
 0.79A 5y7pE-3gmeA:
undetectable		 5y7pE-3gmeA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxa OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		4 ILE A 192
ASN A 213
LEU A 158
LEU A 126
 None
MET  A 296 (-3.9A)
None
None
 0.83A 5y7pE-3gxaA:
undetectable		 5y7pE-3gxaA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		4 ILE A 192
ASN A 213
LEU A 158
LEU A 126
 None
MET  A 600 (-3.9A)
None
None
 0.80A 5y7pE-3ir1A:
undetectable		 5y7pE-3ir1A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4k DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 ILE A 538
LEU A 474
LEU A 454
ALA A 453
 None
 0.82A 5y7pE-3l4kA:
undetectable		 5y7pE-3l4kA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Escherichia
coli) 		PF01135
(PCMT) 		4 ILE A 146
LEU A  73
ALA A  26
LEU A  27
 None
 0.83A 5y7pE-3lbfA:
undetectable		 5y7pE-3lbfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		4 ILE A 459
LEU A 402
LEU A 531
ALA A 530
 None
 0.87A 5y7pE-3mwtA:
undetectable		 5y7pE-3mwtA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		4 TYR A  82
ILE A  85
LEU A  13
ALA A  12
 None
None
EAH  A   1 (-4.8A)
None
 0.72A 5y7pE-3nhiA:
undetectable		 5y7pE-3nhiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6y ASPARTASE

(Bacillus sp.
YM55-1) 		PF00206
(Lyase_1) 		5 TYR A 274
ILE A 347
LEU A 156
ALA A 152
LEU A  45
 TYR  A 274 ( 1.3A)
ILE  A 347 ( 0.7A)
LEU  A 156 ( 0.6A)
ALA  A 152 ( 0.0A)
LEU  A  45 ( 0.6A)
 1.15A 5y7pE-3r6yA:
undetectable		 5y7pE-3r6yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 PHE A 386
LEU A 385
LEU A 493
ALA A 494
 None
 0.80A 5y7pE-3u1kA:
undetectable		 5y7pE-3u1kA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 ILE A  75
LEU A  93
ALA A 123
LEU A 118
 None
 0.77A 5y7pE-3wbkA:
undetectable		 5y7pE-3wbkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 TYR A 758
PHE A 860
ALA A 748
LEU A 762
 None
 0.85A 5y7pE-3x1lA:
undetectable		 5y7pE-3x1lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 PHE A 345
LEU A 344
LEU A 450
ALA A 451
 None
 0.83A 5y7pE-4am3A:
undetectable		 5y7pE-4am3A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayi LIPOPROTEIN GNA1870
CCOMPND 7

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 LEU D 274
LEU D 289
ALA D 290
LEU D 199
 None
 0.87A 5y7pE-4ayiD:
undetectable		 5y7pE-4ayiD:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5d CAPITELLA TELETA
ACHBP

(Capitella
teleta) 		PF02931
(Neur_chan_LBD) 		4 LEU A 172
LEU A  42
ALA A  63
LEU A 133
 None
 0.82A 5y7pE-4b5dA:
undetectable		 5y7pE-4b5dA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		4 ILE A 384
LEU A 577
LEU A 394
ALA A 392
 None
 0.69A 5y7pE-4e2iA:
undetectable		 5y7pE-4e2iA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 457
LEU A 361
ALA A 360
LEU A 354
 None
 0.85A 5y7pE-4e3cA:
undetectable		 5y7pE-4e3cA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo9 E3 SUMO-PROTEIN
LIGASE PIAS2

(Homo sapiens) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 ILE A 279
LEU A 213
LEU A 215
ALA A 216
 None
 0.60A 5y7pE-4fo9A:
undetectable		 5y7pE-4fo9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2n D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE,
NAD-BINDING

(Polaromonas sp.
JS666) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  44
LEU A  70
LEU A  95
ALA A  92
 None
 0.76A 5y7pE-4g2nA:
undetectable		 5y7pE-4g2nA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6v ADHESIN/HEMOLYSIN

(Burkholderia
pseudomallei) 		no annotation 4 ASN A 188
PHE A 222
LEU A 194
ALA A 191
 None
 0.83A 5y7pE-4g6vA:
undetectable		 5y7pE-4g6vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 ILE A 538
LEU A 474
LEU A 454
ALA A 453
 None
 0.80A 5y7pE-4gfhA:
undetectable		 5y7pE-4gfhA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gve NUCLEOPROTEIN

(Tacaribe
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 ILE A 456
LEU A 399
LEU A 533
ALA A 532
 None
 0.78A 5y7pE-4gveA:
undetectable		 5y7pE-4gveA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz2 TYROSYL-DNA
PHOSPHODIESTERASE 2

(Mus musculus) 		PF03372
(Exo_endo_phos) 		4 ILE A 268
PHE A 291
LEU A 337
LEU A 297
 None
 0.85A 5y7pE-4gz2A:
undetectable		 5y7pE-4gz2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis) 		PF00871
(Acetate_kinase) 		4 ILE A 369
LEU A 119
ALA A 115
LEU A  47
 None
 0.75A 5y7pE-4ijnA:
undetectable		 5y7pE-4ijnA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		4 ASN A 258
LEU A 107
LEU A 264
ALA A 261
 None
 0.76A 5y7pE-4ineA:
undetectable		 5y7pE-4ineA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9v POTASSIUM UPTAKE
PROTEIN TRKA

(Vibrio
parahaemolyticus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 PHE A  87
LEU A  89
ALA A  63
LEU A  69
 None
 0.86A 5y7pE-4j9vA:
undetectable		 5y7pE-4j9vA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE

(Francisella
philomiragia) 		PF01048
(PNP_UDP_1) 		4 ILE A 228
LEU A  73
ALA A  91
LEU A 140
 None
 0.69A 5y7pE-4josA:
undetectable		 5y7pE-4josA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		4 ILE A 450
LEU A 427
ALA A 361
LEU A 383
 None
 0.76A 5y7pE-4kmaA:
undetectable		 5y7pE-4kmaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 ASN A 254
LEU A 104
LEU A 260
ALA A 257
 None
 0.78A 5y7pE-4kriA:
undetectable		 5y7pE-4kriA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		4 ILE A  40
LEU A 285
ALA A 260
LEU A 264
 None
 0.77A 5y7pE-4lfeA:
undetectable		 5y7pE-4lfeA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A  69
LEU A  51
ALA A  47
LEU A  13
 None
None
None
NAI  A 401 (-4.8A)
 0.79A 5y7pE-4n54A:
undetectable		 5y7pE-4n54A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		4 ILE A 143
LEU A 183
LEU A 209
ALA A 211
 None
 0.79A 5y7pE-4n6fA:
undetectable		 5y7pE-4n6fA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 PHE A 346
LEU A 345
LEU A 451
ALA A 452
 None
 0.86A 5y7pE-4nbqA:
undetectable		 5y7pE-4nbqA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpk PHOSPHOTRANSFERASE

(Brucella
abortus) 		PF10090
(HPTransfase) 		4 ILE A 148
LEU A 116
LEU A 187
ALA A 188
 None
 0.82A 5y7pE-4qpkA:
undetectable		 5y7pE-4qpkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6i ANTHRAX TOXIN
EXPRESSION
TRANS-ACTING
POSITIVE REGULATOR

(Bacillus
anthracis) 		PF00874
(PRD)
PF05043
(Mga)
PF08279
(HTH_11) 		4 ILE A 287
LEU A 266
LEU A 264
ALA A 261
 None
 0.76A 5y7pE-4r6iA:
undetectable		 5y7pE-4r6iA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ILE A 510
LEU A 497
ALA A 502
LEU A 589
 None
 0.82A 5y7pE-4rt6A:
undetectable		 5y7pE-4rt6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s0v HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		4 ILE A1072
LEU A1108
LEU A1134
ALA A1131
 None
 0.87A 5y7pE-4s0vA:
undetectable		 5y7pE-4s0vA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 ILE A  60
ASN A  97
LEU A  46
LEU A  94
 None
 0.85A 5y7pE-4u09A:
undetectable		 5y7pE-4u09A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6u COG5

(Kluyveromyces
lactis) 		PF10392
(COG5) 		4 ILE B 247
ASN B 218
LEU B 317
LEU B 287
 None
 0.80A 5y7pE-4u6uB:
undetectable		 5y7pE-4u6uB:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ux3 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
3

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		4 ILE A1156
LEU A1172
ALA A1194
LEU A1191
 None
 0.84A 5y7pE-4ux3A:
undetectable		 5y7pE-4ux3A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0c TOLL-LIKE RECEPTOR
13

(Mus musculus) 		PF00560
(LRR_1)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 364
ASN A 430
LEU A 376
LEU A 427
 None
 0.86A 5y7pE-4z0cA:
undetectable		 5y7pE-4z0cA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zad FDC1

(Candida
dubliniensis) 		PF01977
(UbiD) 		4 ILE A 157
LEU A 218
LEU A 276
LEU A 304
 None
 0.85A 5y7pE-4zadA:
undetectable		 5y7pE-4zadA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 4 ILE C 107
LEU C 170
ALA C 200
LEU C 195
 None
 0.74A 5y7pE-5elpC:
undetectable		 5y7pE-5elpC:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE

(Acinetobacter
baumannii) 		PF01218
(Coprogen_oxidas) 		4 ILE A 225
LEU A 140
ALA A 116
LEU A 102
 None
 0.77A 5y7pE-5eo6A:
undetectable		 5y7pE-5eo6A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		4 ILE A  33
LEU A 106
ALA A 107
LEU A 109
 None
 0.81A 5y7pE-5f7vA:
undetectable		 5y7pE-5f7vA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP3

(Deformed wing
virus) 		PF00073
(Rhv) 		4 ILE C 343
PHE C 311
LEU C 354
LEU C 309
 None
 0.87A 5y7pE-5g52C:
undetectable		 5y7pE-5g52C:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		5 TYR A  24
ASN A  79
PHE A  99
LEU A 135
LEU A 138
 None
 0.82A 5y7pE-5gs7A:
49.1		 5y7pE-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		4 TYR A  24
ILE A  58
PHE A  99
LEU A 135
 None
 0.84A 5y7pE-5gs7A:
49.1		 5y7pE-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		5 TYR A  24
PHE A  99
LEU A 133
LEU A 135
LEU A 138
 None
 0.44A 5y7pE-5gs7A:
49.1		 5y7pE-5gs7A:
53.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4v GLUTAMATE--TRNA
LIGASE

(Xanthomonas
oryzae) 		no annotation 4 LEU A 267
LEU A  24
ALA A  20
LEU A  64
 None
 0.84A 5y7pE-5h4vA:
undetectable		 5y7pE-5h4vA:
20.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		7 ILE A  56
ASN A  79
PHE A 100
LEU A 134
LEU A 136
ALA A 137
LEU A 139
 None
OCS  A   2 ( 3.7A)
None
None
None
None
None
 0.37A 5y7pE-5hkeA:
52.4		 5y7pE-5hkeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldl MYRISTOYLATED M-PMV
MATRIX PROTEIN
MUTANT

(Mason-Pfizer
monkey virus) 		PF02337
(Gag_p10) 		4 ILE A  86
LEU A  32
ALA A  29
LEU A  19
 None
 0.67A 5y7pE-5ldlA:
undetectable		 5y7pE-5ldlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 ILE A 146
LEU A 190
LEU A 227
ALA A 228
 None
 0.77A 5y7pE-5muxA:
undetectable		 5y7pE-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oms CYTOCHROME P450

(Amycolatopsis
sp. ATCC 39116) 		no annotation 4 ILE A 196
LEU A 165
ALA A 246
LEU A 144
 None
None
261  A 502 ( 3.5A)
None
 0.81A 5y7pE-5omsA:
undetectable		 5y7pE-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swc CARBONIC ANHYDRASE

(Synechocystis
sp. PCC 6803) 		PF00484
(Pro_CA) 		4 ILE A  34
LEU A 211
ALA A 210
LEU A 159
 None
 0.74A 5y7pE-5swcA:
undetectable		 5y7pE-5swcA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		4 TYR A 384
ASN A 672
LEU A 647
ALA A 648
 None
 0.82A 5y7pE-5te1A:
undetectable		 5y7pE-5te1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tx7 D-ISOMER SPECIFIC
2-HYDROXYACID
DEHYDROGENASE FAMILY
PROTEIN

(Desulfovibrio
vulgaris) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  38
LEU A  63
LEU A  87
ALA A  84
 None
 0.66A 5y7pE-5tx7A:
undetectable		 5y7pE-5tx7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wat HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 4 ASN A 140
LEU A 171
LEU A 146
ALA A 143
 PO4  A 402 (-3.7A)
None
None
None
 0.78A 5y7pE-5watA:
undetectable		 5y7pE-5watA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI

(Zea mays;
Zea mays) 		no annotation
no annotation 		4 ILE L  57
LEU H  70
LEU L  80
ALA L  77
 None
 0.63A 5y7pE-5zjiL:
undetectable		 5y7pE-5zjiL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a6y HISTONE CHAPERONE
ASF1, PUTATIVE

(Plasmodium
falciparum) 		no annotation 4 TYR A 104
ILE A 154
LEU A  31
ALA A  30
 None
 0.87A 5y7pE-6a6yA:
undetectable		 5y7pE-6a6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		4 ILE F  45
PHE F  19
LEU A  13
ALA A  10
 None
 0.82A 5y7pE-6cfwF:
undetectable		 5y7pE-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 ILE M 942
ASN M 568
ALA M 877
LEU M 571
 None
 0.83A 5y7pE-6d6qM:
undetectable		 5y7pE-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 4 ILE A  15
LEU A  98
ALA A  95
LEU A  86
 None
 0.67A 5y7pE-6e85A:
undetectable		 5y7pE-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE GAMMA
SUBUNIT
ATP SYNTHASE EPSILON
SUBUNIT

(Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
no annotation 		4 TYR G 156
ILE G  73
PHE G 141
LEU I  12
 None
 0.72A 5y7pE-6f5dG:
undetectable		 5y7pE-6f5dG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Homo sapiens) 		no annotation 4 ILE A  49
PHE A 224
LEU A  38
ALA A 221
 None
 0.86A 5y7pE-6g79A:
undetectable		 5y7pE-6g79A:
undetectable