SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y7P_C_CHDC401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwz PROTEIN
(DIAMINOPIMELATE
EPIMERASE)

(Haemophilus
influenzae) 		PF01678
(DAP_epimerase) 		4 ILE A  62
PHE A  25
LEU A  33
ALA A  34
 None
 0.76A 5y7pC-1bwzA:
0.0		 5y7pC-1bwzA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		4 PHE A  88
LEU A 166
ALA A 165
LEU A  92
 None
 0.85A 5y7pC-1gz5A:
undetectable		 5y7pC-1gz5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6s L-ALLO-THREONINE
ALDOLASE

(Thermotoga
maritima) 		PF01212
(Beta_elim_lyase) 		4 ILE A 328
LEU A 306
ALA A 307
LEU A 300
 None
 0.72A 5y7pC-1m6sA:
undetectable		 5y7pC-1m6sA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		4 LEU A 311
ILE A 268
LEU A 437
ALA A 438
 None
 0.83A 5y7pC-1nbwA:
0.0		 5y7pC-1nbwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		4 LEU B  39
ILE B  18
LEU B 120
ALA B 121
 None
 0.80A 5y7pC-1nzyB:
0.0		 5y7pC-1nzyB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qbg NAD(P)H
DEHYDROGENASE
[QUINONE] 1

(Homo sapiens) 		PF02525
(Flavodoxin_2) 		4 ILE A 171
ASN A  18
LEU A  41
ALA A  10
 None
FAD  A 501 (-3.6A)
None
None
 0.82A 5y7pC-1qbgA:
0.0		 5y7pC-1qbgA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrd QUINONE-REDUCTASE

(Rattus rattus) 		PF02525
(Flavodoxin_2) 		4 ILE A 171
ASN A  18
LEU A  41
ALA A  10
 None
FAD  A 274 (-3.8A)
None
None
 0.81A 5y7pC-1qrdA:
0.0		 5y7pC-1qrdA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 301
LEU A 362
ALA A 363
LEU A 364
 None
 0.72A 5y7pC-1r2jA:
0.0		 5y7pC-1r2jA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 LEU A  88
ILE A  40
PHE A 469
ALA A 452
 None
 0.85A 5y7pC-1v02A:
0.0		 5y7pC-1v02A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xe4 FEMX

(Weissella
viridescens) 		PF02388
(FemAB) 		4 LEU A 289
ILE A 173
ALA A 279
LEU A 152
 None
 0.75A 5y7pC-1xe4A:
undetectable		 5y7pC-1xe4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		4 LEU A 430
ILE A 353
ALA A 568
LEU A 573
 None
 0.86A 5y7pC-1zsqA:
undetectable		 5y7pC-1zsqA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6p POSSIBLE
PHOSPHOGLYCERATE
MUTASE GPM2

(Mycobacterium
tuberculosis) 		PF00300
(His_Phos_1) 		4 LEU A  83
LEU A 134
ALA A 133
LEU A   8
 None
 0.88A 5y7pC-2a6pA:
undetectable		 5y7pC-2a6pA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bco SUCCINYLGLUTAMATE
DESUCCINYLASE

(Vibrio
parahaemolyticus) 		PF04952
(AstE_AspA) 		4 LEU A 154
ILE A  56
ALA A 188
LEU A 185
 None
 0.87A 5y7pC-2bcoA:
undetectable		 5y7pC-2bcoA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckf RING-HYDROXYLATING
DIOXYGENASE BETA
SUBUNIT

(Sphingomonas
sp. CHY-1) 		PF00866
(Ring_hydroxyl_B) 		4 LEU B 158
TYR B  46
ILE B  44
LEU B  26
 None
 0.76A 5y7pC-2ckfB:
undetectable		 5y7pC-2ckfB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		4 LEU A 308
LEU A 319
ALA A 315
LEU A 100
 None
 0.72A 5y7pC-2cybA:
undetectable		 5y7pC-2cybA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 LEU A 340
TYR A 460
LEU A 233
ALA A 232
 None
 0.82A 5y7pC-2dpgA:
undetectable		 5y7pC-2dpgA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		4 LEU A 131
ILE A 172
LEU A 341
ALA A 338
 None
 0.79A 5y7pC-2felA:
undetectable		 5y7pC-2felA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iml HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF04289
(DUF447) 		4 ILE A  15
PHE A  63
ALA A 105
LEU A  56
 None
 0.83A 5y7pC-2imlA:
undetectable		 5y7pC-2imlA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irm MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7
INTERACTING PROTEIN
1

(Anopheles
gambiae) 		PF00481
(PP2C) 		4 ILE A 273
PHE A 279
ALA A 186
LEU A 282
 None
 0.87A 5y7pC-2irmA:
undetectable		 5y7pC-2irmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivg CYANATE LYASE

(Escherichia
coli) 		PF02560
(Cyanate_lyase) 		4 LEU A  75
ILE A  32
LEU A  20
ALA A  17
 None
 0.83A 5y7pC-2ivgA:
undetectable		 5y7pC-2ivgA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		4 LEU A 304
ILE A 149
LEU A 270
ALA A 254
 NAP  A 402 (-4.0A)
None
None
None
 0.83A 5y7pC-2o7pA:
undetectable		 5y7pC-2o7pA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjv UNCHARACTERIZED
IOLB-LIKE PROTEIN

(Salmonella
enterica) 		PF04962
(KduI) 		4 LEU A 104
ILE A  71
ALA A  94
LEU A  88
 None
None
MLY  A  95 ( 3.3A)
None
 0.81A 5y7pC-2qjvA:
undetectable		 5y7pC-2qjvA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		4 LEU A 299
LEU A 199
ALA A 200
LEU A 211
 None
 0.87A 5y7pC-2w1vA:
undetectable		 5y7pC-2w1vA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtb FATTY ACID
MULTIFUNCTIONAL
PROTEIN (ATMFP2)

(Arabidopsis
thaliana) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 193
LEU A 114
ALA A 113
LEU A 135
 None
 0.88A 5y7pC-2wtbA:
undetectable		 5y7pC-2wtbA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 LEU A 304
ILE A 334
LEU A 257
ALA A 254
 None
 0.77A 5y7pC-2zj8A:
undetectable		 5y7pC-2zj8A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 ILE A 575
ASN A 513
LEU A 519
ALA A 516
 None
 0.87A 5y7pC-3ahiA:
undetectable		 5y7pC-3ahiA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 ILE A 575
ASN A 513
LEU A 519
ALA A 516
 None
 0.83A 5y7pC-3ai7A:
undetectable		 5y7pC-3ai7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 LEU A 883
LEU A 806
ALA A 826
LEU A 843
 None
 0.82A 5y7pC-3ak5A:
undetectable		 5y7pC-3ak5A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq7 GROUP 1 TRUNCATED
HEMOGLOBIN

(Tetrahymena
pyriformis) 		PF01152
(Bac_globin) 		4 LEU A  58
ILE A  87
LEU A  23
ALA A  20
 None
 0.76A 5y7pC-3aq7A:
undetectable		 5y7pC-3aq7A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 LEU A 460
PHE A 482
ALA A 477
LEU A 449
 None
LOP  A 809 (-4.2A)
None
None
 0.83A 5y7pC-3ayfA:
undetectable		 5y7pC-3ayfA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 LEU A 136
ILE A 158
LEU A 124
ALA A 125
 None
 0.73A 5y7pC-3cskA:
undetectable		 5y7pC-3cskA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dte IRRE PROTEIN

(Deinococcus
deserti) 		PF06114
(Peptidase_M78) 		4 ILE A  67
ASN A 117
LEU A 123
ALA A 120
 None
 0.77A 5y7pC-3dteA:
undetectable		 5y7pC-3dteA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzb PREPHENATE
DEHYDROGENASE

(Streptococcus
thermophilus) 		PF02153
(PDH) 		4 LEU A  69
TYR A  79
ALA A  61
LEU A  88
 None
 0.87A 5y7pC-3dzbA:
undetectable		 5y7pC-3dzbA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grn MUTT RELATED PROTEIN

(Methanosarcina
mazei) 		PF00293
(NUDIX) 		4 LEU A  80
ASN A  34
PHE A 129
LEU A  40
 None
 0.84A 5y7pC-3grnA:
undetectable		 5y7pC-3grnA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt0 PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Bacillus cereus) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ILE A  71
ASN A  58
PHE A   7
ALA A  61
 None
 0.77A 5y7pC-3gt0A:
undetectable		 5y7pC-3gt0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 LEU A  85
ILE A 105
LEU A 158
ALA A 155
 None
 0.85A 5y7pC-3gzgA:
undetectable		 5y7pC-3gzgA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcl SPIKE GLYCOPROTEIN

(Murine
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 LEU A  63
TYR A  58
ASN A1014
LEU A1013
 None
 0.84A 5y7pC-3jclA:
undetectable		 5y7pC-3jclA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd3 PHOSPHOSERINE
PHOSPHOHYDROLASE-LIK
E PROTEIN

(Francisella
tularensis) 		PF12710
(HAD) 		4 LEU A 211
ILE A  98
PHE A 101
LEU A 176
 None
 0.74A 5y7pC-3kd3A:
undetectable		 5y7pC-3kd3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Encephalitozoon
cuniculi) 		PF00274
(Glycolytic) 		4 ILE A 177
PHE A 291
LEU A 297
ALA A 294
 None
None
None
2FP  A 345 (-3.5A)
 0.87A 5y7pC-3mbfA:
undetectable		 5y7pC-3mbfA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		4 TYR A  82
ILE A  85
LEU A  13
ALA A  12
 None
None
EAH  A   1 (-4.8A)
None
 0.83A 5y7pC-3nhiA:
undetectable		 5y7pC-3nhiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 LEU A 205
TYR A 201
ILE A 166
ALA A 243
 None
 0.82A 5y7pC-3oqnA:
undetectable		 5y7pC-3oqnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I

(Solanum
habrochaites) 		PF12697
(Abhydrolase_6) 		4 LEU A 183
TYR A 186
ILE A 191
LEU A  68
 None
 0.78A 5y7pC-3sttA:
undetectable		 5y7pC-3sttA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tq9 DIHYDROFOLATE
REDUCTASE

(Coxiella
burnetii) 		PF00186
(DHFR_1) 		4 LEU A  55
ILE A   6
LEU A  25
LEU A  21
 MTX  A2001 ( 4.5A)
MTX  A2001 (-4.0A)
None
MTX  A2001 (-4.4A)
 0.79A 5y7pC-3tq9A:
undetectable		 5y7pC-3tq9A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx1 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Listeria
monocytogenes) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 LEU A 116
ILE A  86
ALA A 129
LEU A 130
 None
None
FAD  A 299 (-4.0A)
None
 0.67A 5y7pC-3tx1A:
undetectable		 5y7pC-3tx1A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 TYR A 758
PHE A 860
ALA A 748
LEU A 762
 None
 0.88A 5y7pC-3x1lA:
undetectable		 5y7pC-3x1lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgj 4-HYDROXYPHENYLPYRUV
IC ACID DIOXYGENASE

(Streptomyces
coelicolor) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 LEU A 358
ILE A 236
PHE A 233
ALA A 263
 RMN  A1369 ( 4.1A)
RMN  A1369 ( 4.8A)
None
CO  A1368 ( 4.4A)
 0.85A 5y7pC-3zgjA:
undetectable		 5y7pC-3zgjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 197
LEU A 114
ALA A 113
LEU A 137
 None
COA  A1730 ( 4.4A)
None
None
 0.85A 5y7pC-4b3iA:
undetectable		 5y7pC-4b3iA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bof ARGININE DEIMINASE

(Streptococcus
pyogenes) 		PF02274
(Amidinotransf) 		4 ILE A 290
LEU A 263
ALA A 233
LEU A 227
 None
 0.80A 5y7pC-4bofA:
undetectable		 5y7pC-4bofA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		4 LEU A 337
ILE A 262
LEU A 489
ALA A 488
 None
None
FLC  A1505 ( 4.0A)
FLC  A1506 (-3.6A)
 0.69A 5y7pC-4c02A:
undetectable		 5y7pC-4c02A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d70 SORTASE FAMILY
PROTEIN

(Clostridium
perfringens) 		PF04203
(Sortase) 		4 LEU A 124
ILE A  65
PHE A 139
LEU A 185
 None
 0.86A 5y7pC-4d70A:
undetectable		 5y7pC-4d70A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg DIAPHANOUS PROTEIN

(Entamoeba
histolytica) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		4 ILE B 243
PHE B 290
ALA B 273
LEU B 277
 None
 0.88A 5y7pC-4dvgB:
undetectable		 5y7pC-4dvgB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3c INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT BETA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASN A 457
LEU A 361
ALA A 360
LEU A 354
 None
 0.88A 5y7pC-4e3cA:
undetectable		 5y7pC-4e3cA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 LEU A  40
PHE A 146
LEU A 316
ALA A 313
 None
 0.59A 5y7pC-4evqA:
undetectable		 5y7pC-4evqA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6v ADHESIN/HEMOLYSIN

(Burkholderia
pseudomallei) 		no annotation 4 ASN A 188
PHE A 222
LEU A 194
ALA A 191
 None
 0.83A 5y7pC-4g6vA:
undetectable		 5y7pC-4g6vA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV

(Borreliella
burgdorferi) 		PF00496
(SBP_bac_5) 		4 LEU A 118
ILE A 137
LEU A 158
ALA A 157
 None
 0.86A 5y7pC-4gl8A:
undetectable		 5y7pC-4gl8A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyk DNA POLYMERASE IV

(Sulfolobus
acidocaldarius) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 LEU A 214
ILE A 187
LEU A 176
ALA A 230
 None
 0.69A 5y7pC-4hykA:
undetectable		 5y7pC-4hykA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis) 		PF00871
(Acetate_kinase) 		4 ILE A 369
LEU A 119
ALA A 115
LEU A  47
 None
 0.75A 5y7pC-4ijnA:
undetectable		 5y7pC-4ijnA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l01 TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 848
LEU A 698
ALA A 695
LEU A 783
 None
 0.73A 5y7pC-4l01A:
undetectable		 5y7pC-4l01A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n54 INOSITOL
DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A  69
LEU A  51
ALA A  47
LEU A  13
 None
None
None
NAI  A 401 (-4.8A)
 0.83A 5y7pC-4n54A:
undetectable		 5y7pC-4n54A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nc6 RAB
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 ILE A 596
LEU A 671
ALA A 667
LEU A 659
 None
 0.88A 5y7pC-4nc6A:
undetectable		 5y7pC-4nc6A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 285
ASN A 299
LEU A 305
ALA A 302
 None
 0.76A 5y7pC-4q3nA:
undetectable		 5y7pC-4q3nA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 LEU A 343
ILE A  15
ALA A 320
LEU A 324
 None
 0.78A 5y7pC-4rnwA:
undetectable		 5y7pC-4rnwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnx NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 LEU A  93
ILE A 164
ALA A  70
LEU A  74
 None
 0.78A 5y7pC-4rnxA:
undetectable		 5y7pC-4rnxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ILE A 161
ASN A 535
LEU A 497
ALA A 498
 None
 0.83A 5y7pC-4u14A:
undetectable		 5y7pC-4u14A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xci THERMOSOME SUBUNIT
ALPHA

(Sulfolobus
solfataricus) 		PF00118
(Cpn60_TCP1) 		4 LEU A  99
LEU A 134
ALA A 131
LEU A 427
 None
 0.87A 5y7pC-4xciA:
undetectable		 5y7pC-4xciA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yl0 PROSTAGLANDIN E
SYNTHASE

(Homo sapiens) 		PF01124
(MAPEG) 		4 ILE A 144
PHE A  87
LEU A  13
ALA A  12
 None
 0.88A 5y7pC-4yl0A:
undetectable		 5y7pC-4yl0A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE AMINO ACID
TRANSPORT SYSTEM,
PERMEASE COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 4 LEU D  67
ILE D  74
ALA D  29
LEU D  25
 HIS  D 301 ( 4.7A)
None
None
None
 0.63A 5y7pC-4ymwD:
undetectable		 5y7pC-4ymwD:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ync NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		4 LEU A 244
ILE A 315
ALA A 221
LEU A 225
 None
 0.78A 5y7pC-4yncA:
undetectable		 5y7pC-4yncA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdk CTP SYNTHASE

(Mycobacterium
tuberculosis) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 LEU A 263
ILE A 150
PHE A 183
ALA A 219
 None
 0.83A 5y7pC-4zdkA:
undetectable		 5y7pC-4zdkA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 LEU A 104
ILE A 807
LEU A 302
ALA A 299
 None
 0.87A 5y7pC-5aw4A:
undetectable		 5y7pC-5aw4A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF03170
(BcsB) 		4 LEU B 200
ILE B 270
ALA B 229
LEU B 226
 None
 0.80A 5y7pC-5ej1B:
undetectable		 5y7pC-5ej1B:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7v LMO0181 PROTEIN

(Listeria
monocytogenes) 		PF01547
(SBP_bac_1) 		4 ILE A  33
LEU A 106
ALA A 107
LEU A 109
 None
 0.78A 5y7pC-5f7vA:
undetectable		 5y7pC-5f7vA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT GAMMA

(Sporosarcina
pasteurii) 		PF00547
(Urease_gamma) 		5 ILE A  80
ASN A  31
LEU A  21
ALA A  20
LEU A  30
 None
 1.27A 5y7pC-5fseA:
undetectable		 5y7pC-5fseA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2x GROUP II
INTRON-ENCODED
PROTEIN LTRA

(Lactococcus
lactis) 		PF00078
(RVT_1)
PF01348
(Intron_maturas2) 		4 LEU C 194
ILE C 224
ALA C 113
LEU C   8
 None
 0.72A 5y7pC-5g2xC:
undetectable		 5y7pC-5g2xC:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		4 TYR A  24
PHE A  99
LEU A 135
LEU A 138
 None
 0.49A 5y7pC-5gs7A:
49.0		 5y7pC-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		6 LEU A  18
ILE A  56
PHE A 100
LEU A 136
ALA A 137
LEU A 139
 OCS  A   2 ( 3.9A)
None
None
None
None
None
 1.26A 5y7pC-5hkeA:
52.3		 5y7pC-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		7 LEU A  20
ILE A  56
ASN A  79
PHE A 100
LEU A 136
ALA A 137
LEU A 139
 None
None
OCS  A   2 ( 3.7A)
None
None
None
None
 0.38A 5y7pC-5hkeA:
52.3		 5y7pC-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		4 LEU A  20
TYR A  24
ASN A  79
ALA A 137
 None
None
OCS  A   2 ( 3.7A)
None
 0.82A 5y7pC-5hkeA:
52.3		 5y7pC-5hkeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		4 ILE A 170
ASN A 367
PHE A 487
LEU A 366
 None
 0.83A 5y7pC-5hs1A:
undetectable		 5y7pC-5hs1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 431
ILE A 470
PHE A 488
LEU A 493
 None
 0.82A 5y7pC-5ie2A:
undetectable		 5y7pC-5ie2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j49 UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Paraburkholderia
xenovorans) 		PF00483
(NTP_transferase) 		4 ILE A  50
PHE A 101
LEU A 121
ALA A 118
 None
 0.87A 5y7pC-5j49A:
undetectable		 5y7pC-5j49A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 LEU A 378
LEU A 255
ALA A 256
LEU A 382
 None
 0.87A 5y7pC-5ja1A:
undetectable		 5y7pC-5ja1A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldl MYRISTOYLATED M-PMV
MATRIX PROTEIN
MUTANT

(Mason-Pfizer
monkey virus) 		PF02337
(Gag_p10) 		4 ILE A  86
LEU A  32
ALA A  29
LEU A  19
 None
 0.67A 5y7pC-5ldlA:
undetectable		 5y7pC-5ldlA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti8 AMINOTRANSFERASE

(Pseudomonas sp.
M1) 		PF00202
(Aminotran_3) 		4 TYR A 278
ILE A 230
LEU A 358
ALA A 355
 None
 0.81A 5y7pC-5ti8A:
undetectable		 5y7pC-5ti8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvi NON SPECIFIC LIPID
TRANSFER PROTEIN

(Solanum
melongena) 		PF00234
(Tryp_alpha_amyl) 		4 ILE V  86
ASN V  36
ALA V  39
LEU V  35
 None
 0.75A 5y7pC-5tviV:
undetectable		 5y7pC-5tviV:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v4p NADPH DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 244
ILE A 315
ALA A 221
LEU A 225
 None
 0.78A 5y7pC-5v4pA:
undetectable		 5y7pC-5v4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjw RHIZOBIALES-LIKE
PHOSPHATASE 2

(Arabidopsis
thaliana) 		no annotation 4 LEU A  92
LEU A  77
ALA A  78
LEU A 242
 None
 0.74A 5y7pC-5vjwA:
undetectable		 5y7pC-5vjwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygu DIAMINOPIMELATE
EPIMERASE

(Escherichia
coli) 		no annotation 4 ILE A  62
PHE A  25
LEU A  33
ALA A  34
 None
 0.88A 5y7pC-5yguA:
undetectable		 5y7pC-5yguA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a6y HISTONE CHAPERONE
ASF1, PUTATIVE

(Plasmodium
falciparum) 		no annotation 4 TYR A 104
ILE A 154
LEU A  31
ALA A  30
 None
 0.86A 5y7pC-6a6yA:
undetectable		 5y7pC-6a6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 4 LEU A 143
ILE A 113
ALA A 177
LEU A 184
 None
 0.85A 5y7pC-6b3bA:
undetectable		 5y7pC-6b3bA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bzh PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Mus musculus) 		no annotation 4 LEU A  77
ILE A  97
ALA A  54
LEU A  58
 None
 0.72A 5y7pC-6bzhA:
undetectable		 5y7pC-6bzhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT E
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		4 ILE F  45
PHE F  19
LEU A  13
ALA A  10
 None
 0.72A 5y7pC-6cfwF:
undetectable		 5y7pC-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME RNA HELICASE
MTR4

(Homo sapiens) 		no annotation 4 ILE M 942
ASN M 568
ALA M 877
LEU M 571
 None
 0.80A 5y7pC-6d6qM:
undetectable		 5y7pC-6d6qM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN

(Sulfolobus sp.
L00 11) 		no annotation 4 LEU A 119
ILE A 149
PHE A 144
LEU A 111
 None
 0.86A 5y7pC-6dgcA:
undetectable		 5y7pC-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 4 ILE A  15
LEU A  98
ALA A  95
LEU A  86
 None
 0.67A 5y7pC-6e85A:
undetectable		 5y7pC-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejj WLAC PROTEIN

(Campylobacter
jejuni) 		no annotation 4 LEU A  12
ILE A   8
LEU A  28
ALA A  25
 None
 0.82A 5y7pC-6ejjA:
undetectable		 5y7pC-6ejjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 680
ILE A 691
LEU A 671
ALA A 672
 None
 0.82A 5y7pC-6emkA:
undetectable		 5y7pC-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE GAMMA
SUBUNIT
ATP SYNTHASE EPSILON
SUBUNIT

(Trypanosoma
brucei;
Trypanosoma
brucei) 		no annotation
no annotation 		4 TYR G 156
ILE G  73
PHE G 141
LEU I  12
 None
 0.76A 5y7pC-6f5dG:
undetectable		 5y7pC-6f5dG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC

(Acetobacterium
woodii) 		no annotation 4 ILE C  40
PHE C  47
LEU C  13
ALA C  14
 None
 0.88A 5y7pC-6fahC:
undetectable		 5y7pC-6fahC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 4 LEU A 271
TYR A 321
ALA A 195
LEU A 156
 None
None
FAD  A 701 (-3.4A)
FAD  A 701 (-3.9A)
 0.73A 5y7pC-6fcxA:
undetectable		 5y7pC-6fcxA:
undetectable