SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y7P_B_CHDB401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)

(Lactobacillus
sp. 30A) 		PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C) 		5 LEU A 645
ILE A 688
PHE A 703
LEU A 658
ALA A 657
 None
 1.16A 5y7pB-1c4kA:
0.0		 5y7pB-1c4kA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 ILE A 202
LEU A 199
LEU A 243
ALA A 246
LEU A 248
 None
 1.19A 5y7pB-1e6zA:
0.0		 5y7pB-1e6zA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy2 ASPARTYL DIPEPTIDASE

(Salmonella
enterica) 		PF03575
(Peptidase_S51) 		5 ILE A  82
LEU A 115
LEU A  23
ALA A  20
LEU A   6
 None
 1.07A 5y7pB-1fy2A:
0.0		 5y7pB-1fy2A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iov D-ALA:D-ALA LIGASE

(Escherichia
coli) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A  30
LEU A  50
LEU A  62
ALA A  61
LEU A   9
 None
 1.26A 5y7pB-1iovA:
0.0		 5y7pB-1iovA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		5 LEU A 187
ILE A 756
ASN A 107
ALA A 964
LEU A 103
 None
 1.12A 5y7pB-1jqoA:
0.0		 5y7pB-1jqoA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		5 ILE A  15
LEU A  19
PHE A  26
LEU A  34
ALA A  35
 None
 0.95A 5y7pB-1jztA:
0.0		 5y7pB-1jztA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 TYR A 282
ILE A 294
LEU A 245
LEU A 164
ALA A 165
 None
 1.19A 5y7pB-1p43A:
0.0		 5y7pB-1p43A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		5 LEU A  68
ILE A 111
LEU A 112
PHE A  58
ALA A 348
 None
 1.23A 5y7pB-1p75A:
0.0		 5y7pB-1p75A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		5 LEU A  29
ILE A 352
LEU A 351
LEU A 298
ALA A 301
 None
 1.14A 5y7pB-1v5bA:
0.0		 5y7pB-1v5bA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 LEU A 335
ILE A 516
LEU A 520
ALA A 462
LEU A 316
 None
 0.84A 5y7pB-1x9nA:
undetectable		 5y7pB-1x9nA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9j SEC1 FAMILY DOMAIN
CONTAINING PROTEIN 1

(Rattus
norvegicus) 		PF00995
(Sec1) 		5 TYR A 145
ILE A  10
ASN A 112
ALA A  17
LEU A  18
 None
 1.22A 5y7pB-1y9jA:
undetectable		 5y7pB-1y9jA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 357
ILE A  74
LEU A  68
ALA A  17
LEU A  25
 None
 1.16A 5y7pB-1yqdA:
undetectable		 5y7pB-1yqdA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh4 KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg) 		5 LEU A  55
ILE A  13
LEU A  17
LEU A  48
LEU A   5
 None
 1.20A 5y7pB-1zh4A:
undetectable		 5y7pB-1zh4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 ILE A 248
PHE A 334
LEU A 380
ALA A 323
LEU A 326
 None
 1.26A 5y7pB-1zr6A:
undetectable		 5y7pB-1zr6A:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		5 ILE A 170
LEU A 169
ASN A 139
ALA A 119
LEU A 138
 None
 1.24A 5y7pB-2bi3A:
undetectable		 5y7pB-2bi3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eh3 TRANSCRIPTIONAL
REGULATOR

(Aquifex
aeolicus) 		PF00440
(TetR_N) 		5 ILE A 138
LEU A 142
PHE A 119
ASN A  68
LEU A  64
 None
 1.17A 5y7pB-2eh3A:
undetectable		 5y7pB-2eh3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		5 LEU A 241
ILE A 118
LEU A 123
LEU A 170
ALA A 168
 None
 1.24A 5y7pB-2g9bA:
undetectable		 5y7pB-2g9bA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0k OXIDOREDUCTASE

(Brevibacterium
sterolicum) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 LEU A 612
TYR A 594
ILE A 597
LEU A 197
ALA A 198
 None
None
None
None
FAD  A 700 (-3.3A)
 1.22A 5y7pB-2i0kA:
undetectable		 5y7pB-2i0kA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		5 ILE A 120
LEU A  64
LEU A 103
ALA A 102
LEU A  71
 None
 1.04A 5y7pB-2i34A:
undetectable		 5y7pB-2i34A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922

(Mycobacterium
tuberculosis) 		PF00691
(OmpA)
PF04972
(BON) 		5 LEU A 153
PHE A 151
LEU A 106
ALA A 109
LEU A 113
 None
 1.26A 5y7pB-2l26A:
undetectable		 5y7pB-2l26A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 LEU A 380
ILE A 363
LEU A 425
ALA A 438
LEU A 442
 None
 1.24A 5y7pB-2nrrA:
undetectable		 5y7pB-2nrrA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrx UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 LEU A 380
ILE A 363
LEU A 425
ALA A 438
LEU A 442
 None
 1.25A 5y7pB-2nrxA:
undetectable		 5y7pB-2nrxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb4 ATP-DEPENDENT RNA
HELICASE DDX25

(Homo sapiens) 		PF00271
(Helicase_C) 		5 LEU A 456
LEU A 470
ASN A 412
LEU A 443
ALA A 444
 None
 1.04A 5y7pB-2rb4A:
undetectable		 5y7pB-2rb4A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7z PENTAPEPTIDE REPEAT
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF13599
(Pentapeptide_4) 		5 TYR A  34
ILE A  37
LEU A  39
ALA A  27
LEU A  47
 None
 1.10A 5y7pB-2w7zA:
undetectable		 5y7pB-2w7zA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 268
LEU A 223
PHE A 224
LEU A 125
ALA A 124
 None
 1.18A 5y7pB-2y7jA:
undetectable		 5y7pB-2y7jA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 421
LEU A 356
PHE A 358
LEU A 385
LEU A 406
 None
 1.20A 5y7pB-2z63A:
undetectable		 5y7pB-2z63A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		5 ILE A 208
LEU A  30
PHE A  35
ASN A 288
ALA A 236
 None
 1.26A 5y7pB-3bqwA:
undetectable		 5y7pB-3bqwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccy PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Bordetella
parapertussis) 		PF00440
(TetR_N) 		5 LEU A 139
ILE A 132
LEU A 131
LEU A  94
LEU A  78
 None
 1.26A 5y7pB-3ccyA:
undetectable		 5y7pB-3ccyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 LEU A 396
LEU A 349
LEU A 337
ALA A 343
LEU A 444
 None
 1.26A 5y7pB-3cemA:
undetectable		 5y7pB-3cemA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		5 LEU A 511
ILE A 434
LEU A 437
ASN A 262
LEU A 293
 None
 1.18A 5y7pB-3do6A:
undetectable		 5y7pB-3do6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeh PUTATIVE LIGHT AND
REDOX SENSING
HISTIDINE KINASE

(Haloarcula
marismortui) 		PF08447
(PAS_3) 		5 TYR A  41
ILE A  23
ASN A  61
LEU A  31
LEU A  60
 None
 1.23A 5y7pB-3eehA:
undetectable		 5y7pB-3eehA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eiq PROGRAMMED CELL
DEATH PROTEIN 4

(Mus musculus) 		PF02847
(MA3) 		5 ILE C 273
LEU C 223
ASN C 182
LEU C 188
ALA C 185
 None
 1.23A 5y7pB-3eiqC:
undetectable		 5y7pB-3eiqC:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		5 LEU A 348
LEU A 359
ASN A  62
PHE A 430
ALA A  56
 None
 1.17A 5y7pB-3fcrA:
undetectable		 5y7pB-3fcrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd3 CHROMOSOME
REPLICATION
INITIATION INHIBITOR
PROTEIN

(Agrobacterium
fabrum) 		PF03466
(LysR_substrate) 		5 LEU A 222
TYR A 186
LEU A 265
LEU A 124
ALA A 121
 EDO  A 322 (-4.4A)
None
None
None
None
 1.14A 5y7pB-3fd3A:
undetectable		 5y7pB-3fd3A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnb ACYLAMINOACYL
PEPTIDASE SMU_737

(Streptococcus
mutans) 		PF12146
(Hydrolase_4) 		5 LEU A 100
ILE A  32
ASN A  63
LEU A  69
ALA A  66
 None
 1.14A 5y7pB-3fnbA:
undetectable		 5y7pB-3fnbA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 307
ILE A 247
LEU A 250
PHE A 223
LEU A 228
 None
 1.22A 5y7pB-3fxiA:
undetectable		 5y7pB-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 421
LEU A 356
PHE A 358
LEU A 385
LEU A 406
 None
 1.23A 5y7pB-3fxiA:
undetectable		 5y7pB-3fxiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5t TRANS-ACONITATE
3-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF13847
(Methyltransf_31) 		5 LEU A  58
TYR A  26
LEU A 228
ALA A 146
LEU A 295
 None
 1.15A 5y7pB-3g5tA:
undetectable		 5y7pB-3g5tA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0n UNCHARACTERIZED
PROTEIN DUF1470

(Jannaschia sp.
CCS1) 		PF07336
(ABATE)
PF11706
(zf-CGNR) 		5 LEU A  65
LEU A  11
LEU A  76
ALA A  72
LEU A  88
 None
 1.10A 5y7pB-3h0nA:
undetectable		 5y7pB-3h0nA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A 549
ASN A 735
LEU A 601
ALA A 602
LEU A 698
 None
 1.09A 5y7pB-3hhdA:
undetectable		 5y7pB-3hhdA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT H

(Saccharomyces
cerevisiae) 		PF03224
(V-ATPase_H_N)
PF11698
(V-ATPase_H_C) 		5 LEU P 127
ILE P 141
LEU P 140
LEU P 190
LEU P 164
 None
 1.15A 5y7pB-3j9tP:
undetectable		 5y7pB-3j9tP:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S9,
MITOCHONDRIAL

(Bos taurus) 		PF00380
(Ribosomal_S9) 		5 ILE I 293
LEU I 313
PHE I 317
LEU I 346
LEU I 369
 None
 1.11A 5y7pB-3jd5I:
undetectable		 5y7pB-3jd5I:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcu PROBABLE FORMATE
TRANSPORTER 1

(Escherichia
coli) 		PF01226
(Form_Nir_trans) 		5 TYR A 138
ILE A 223
LEU A 150
ASN A 142
ALA A 234
 None
 1.24A 5y7pB-3kcuA:
undetectable		 5y7pB-3kcuA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksr PUTATIVE SERINE
HYDROLASE

(Xanthomonas
campestris) 		PF00326
(Peptidase_S9) 		5 LEU A 128
ILE A  84
LEU A  81
LEU A 166
ALA A 167
 None
 1.13A 5y7pB-3ksrA:
undetectable		 5y7pB-3ksrA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2n ANTHRAX TOXIN
RECEPTOR 1

(Homo sapiens) 		no annotation 5 LEU F 153
LEU F  49
PHE F  85
PHE F  47
ALA F 177
 None
 1.13A 5y7pB-3n2nF:
undetectable		 5y7pB-3n2nF:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnm CURA

(Lyngbya
majuscula) 		PF05721
(PhyH) 		5 ILE A  80
PHE A  25
LEU A 102
ALA A 243
LEU A 137
 None
None
None
FMT  A 500 (-3.6A)
None
 0.96A 5y7pB-3nnmA:
undetectable		 5y7pB-3nnmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odm PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Clostridium
perfringens) 		PF14010
(PEPcase_2) 		5 LEU A 429
TYR A 433
ILE A 435
PHE A 442
LEU A 477
 None
 1.22A 5y7pB-3odmA:
undetectable		 5y7pB-3odmA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 ILE A 641
LEU A 620
LEU A 632
ALA A 663
LEU A 651
 None
 1.13A 5y7pB-3ogrA:
undetectable		 5y7pB-3ogrA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfw RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large) 		5 ILE A 151
LEU A 138
LEU A 162
ALA A 135
LEU A 341
 None
 1.25A 5y7pB-3qfwA:
undetectable		 5y7pB-3qfwA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcn BETA-N-ACETYLHEXOSAM
INIDASE

(Paenarthrobacter
aurescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		5 LEU A 166
ILE A 453
PHE A 157
PHE A 466
LEU A 503
 None
None
None
GOL  A 560 (-4.6A)
None
 1.15A 5y7pB-3rcnA:
undetectable		 5y7pB-3rcnA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		5 ILE A 283
LEU A 280
PHE A 279
ASN A 220
LEU A  35
 None
 1.20A 5y7pB-3s6oA:
undetectable		 5y7pB-3s6oA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		5 LEU A 225
ILE A  87
PHE A  91
LEU A 288
ALA A 286
 None
 1.23A 5y7pB-3wwxA:
undetectable		 5y7pB-3wwxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 LEU A 747
ILE A 864
LEU A 861
PHE A 858
LEU A 842
 None
 1.23A 5y7pB-3x1lA:
undetectable		 5y7pB-3x1lA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b18 IMPORTIN SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 LEU A 432
ILE A 450
PHE A 382
ALA A 401
LEU A 389
 None
 1.24A 5y7pB-4b18A:
undetectable		 5y7pB-4b18A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b56 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 1

(Mus musculus) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		5 LEU A 354
ILE A 217
LEU A 220
LEU A 389
LEU A 195
 None
 1.25A 5y7pB-4b56A:
undetectable		 5y7pB-4b56A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bug ANCILLARY PROTEIN 1

(Streptococcus
pyogenes) 		PF08341
(TED) 		5 LEU A 711
ILE A 657
LEU A 648
LEU A 637
LEU A 670
 None
 1.26A 5y7pB-4bugA:
undetectable		 5y7pB-4bugA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1
5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus;
Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor)
no annotation 		5 LEU A 398
ILE C 543
LEU C 546
LEU A 432
LEU A 451
 None
 1.26A 5y7pB-4cfhA:
undetectable		 5y7pB-4cfhA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 LEU A 363
ILE A  62
LEU A  53
LEU A 319
ALA A 349
 None
 1.23A 5y7pB-4d9iA:
undetectable		 5y7pB-4d9iA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 109
ILE A 259
LEU A 253
ASN A  85
ALA A  83
 None
 1.26A 5y7pB-4emwA:
undetectable		 5y7pB-4emwA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3y DIHYDRODIPICOLINATE
REDUCTASE

(Burkholderia
thailandensis) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		5 LEU A  35
LEU A  83
LEU A  90
ALA A  89
LEU A  96
 None
 0.99A 5y7pB-4f3yA:
undetectable		 5y7pB-4f3yA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 LEU A 350
ILE A 380
LEU A 378
LEU A 416
LEU A 278
 None
 1.24A 5y7pB-4fqdA:
undetectable		 5y7pB-4fqdA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		5 ILE A 166
LEU A 162
ASN A  53
LEU A 155
ALA A 154
 ILE  A 166 ( 0.7A)
LEU  A 162 ( 0.6A)
ASN  A  53 ( 0.6A)
LEU  A 155 ( 0.5A)
ALA  A 154 ( 0.0A)
 1.06A 5y7pB-4jbeA:
undetectable		 5y7pB-4jbeA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lim DNA PRIMASE SMALL
SUBUNIT

(Saccharomyces
cerevisiae) 		PF01896
(DNA_primase_S) 		5 LEU A 213
TYR A 310
LEU A 313
LEU A 148
ALA A 147
 None
 1.16A 5y7pB-4limA:
undetectable		 5y7pB-4limA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll8 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1363
ILE A1335
LEU A1353
LEU A1432
LEU A1383
 None
 0.97A 5y7pB-4ll8A:
undetectable		 5y7pB-4ll8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 680
ILE A 576
PHE A 581
LEU A 541
LEU A 562
 None
 0.93A 5y7pB-4m7eA:
undetectable		 5y7pB-4m7eA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		5 LEU A 288
ILE A  42
LEU A  65
ASN A 212
LEU A 219
 None
 1.25A 5y7pB-4n06A:
undetectable		 5y7pB-4n06A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		5 LEU A 335
PHE A 239
LEU A 314
ALA A 312
LEU A 352
 None
 0.98A 5y7pB-4nz0A:
undetectable		 5y7pB-4nz0A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU B 284
ILE B 128
LEU B 129
LEU B 275
ALA B 278
 None
 1.17A 5y7pB-4o27B:
undetectable		 5y7pB-4o27B:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 5 TYR A 717
ILE A 693
LEU A 667
PHE A 645
LEU A 672
 None
 1.20A 5y7pB-4oj5A:
undetectable		 5y7pB-4oj5A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyr PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Chromobacterium
violaceum) 		PF04348
(LppC) 		5 LEU A  90
ILE A 154
LEU A 342
ALA A 339
LEU A 335
 None
None
None
None
GSH  A 401 (-4.8A)
 1.20A 5y7pB-4pyrA:
undetectable		 5y7pB-4pyrA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A  86
ILE A  78
LEU A  53
ALA A  36
LEU A  37
 None
 1.20A 5y7pB-4u09A:
undetectable		 5y7pB-4u09A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		5 ILE A 837
LEU A 838
ASN A 924
ALA A 920
LEU A 921
 None
 1.09A 5y7pB-4uvkA:
undetectable		 5y7pB-4uvkA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 LEU A 747
ILE A 864
LEU A 861
PHE A 858
LEU A 842
 None
 1.24A 5y7pB-4w8yA:
undetectable		 5y7pB-4w8yA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wv3 ANTHRANILATE-COA
LIGASE

(Stigmatella
aurantiaca) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 TYR A 192
ILE A 229
LEU A 228
LEU A  65
ALA A  87
 None
 1.23A 5y7pB-4wv3A:
undetectable		 5y7pB-4wv3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta) 		PF01036
(Bac_rhodopsin) 		5 ILE A 181
PHE A 211
PHE A 122
LEU A  63
LEU A 262
 None
None
LFA  A 319 ( 4.5A)
None
None
 1.25A 5y7pB-4xtlA:
undetectable		 5y7pB-4xtlA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhs ASPARTATE
SEMIALDEHYDE
DEHYDROGENASE

(Trichophyton
rubrum) 		no annotation 5 TYR D 277
LEU D 166
ASN D 127
LEU D 159
LEU D 220
 None
 1.18A 5y7pB-4zhsD:
undetectable		 5y7pB-4zhsD:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zms RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 ILE A 159
ASN A 185
LEU A 181
ALA A 189
LEU A 178
 None
 1.22A 5y7pB-4zmsA:
undetectable		 5y7pB-4zmsA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqi D-ALANINE--D-ALANINE
LIGASE

(Yersinia pestis) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 LEU A  30
LEU A  50
LEU A  62
ALA A  61
LEU A   9
 None
 1.25A 5y7pB-4zqiA:
undetectable		 5y7pB-4zqiA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG

(Thermococcus
kodakarensis) 		PF10609
(ParA) 		5 LEU B 154
LEU B  35
LEU B  42
ALA B  41
LEU B  53
 None
ACP  B 301 (-3.9A)
None
None
None
 1.15A 5y7pB-5auoB:
undetectable		 5y7pB-5auoB:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3r IMP-18

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A  57
TYR A  35
ILE A  27
PHE A  81
ASN A  60
 None
 1.11A 5y7pB-5b3rA:
undetectable		 5y7pB-5b3rA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cgz 4-OXALMESACONATE
HYDRATASE

(Pseudomonas
putida) 		PF02585
(PIG-L) 		5 LEU A   9
LEU A  99
LEU A 129
ALA A 130
LEU A  41
 None
 1.16A 5y7pB-5cgzA:
undetectable		 5y7pB-5cgzA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cth BIDIRECTIONAL SUGAR
TRANSPORTER SWEET2B

(Oryza sativa) 		PF03083
(MtN3_slv) 		5 LEU A 143
PHE A  83
LEU A  21
ALA A  20
LEU A  23
 None
 1.24A 5y7pB-5cthA:
undetectable		 5y7pB-5cthA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 TYR B 657
ILE B 660
LEU B 664
LEU B 550
ALA B 551
 None
 1.00A 5y7pB-5dlqB:
undetectable		 5y7pB-5dlqB:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE
PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides;
Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ)
PF03170
(BcsB) 		5 TYR A 451
LEU A  76
LEU A  44
ALA A  41
LEU B 697
 None
 1.23A 5y7pB-5ej1A:
undetectable		 5y7pB-5ej1A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsg MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HANTAVIRUS
NUCLEOPROTEIN

(Hantaan
orthohantavirus) 		PF00846
(Hanta_nucleocap)
PF13416
(SBP_bac_8) 		5 ILE A 325
LEU A 328
PHE A 331
LEU A 228
ALA A 229
 None
 1.20A 5y7pB-5fsgA:
undetectable		 5y7pB-5fsgA:
19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		7 TYR A  24
ILE A  58
LEU A  63
ASN A  79
PHE A  99
LEU A 135
LEU A 138
 None
 1.06A 5y7pB-5gs7A:
48.7		 5y7pB-5gs7A:
53.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		7 LEU A  18
LEU A  63
ASN A  79
PHE A 100
LEU A 136
ALA A 137
LEU A 139
 OCS  A   2 ( 3.9A)
None
OCS  A   2 ( 3.7A)
None
None
None
None
 1.39A 5y7pB-5hkeA:
52.3		 5y7pB-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		8 LEU A  18
TYR A  24
ILE A  56
LEU A  63
PHE A 100
LEU A 136
ALA A 137
LEU A 139
 OCS  A   2 ( 3.9A)
None
None
None
None
None
None
None
 1.43A 5y7pB-5hkeA:
52.3		 5y7pB-5hkeA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		9 LEU A  20
TYR A  24
ILE A  56
LEU A  63
PHE A  65
PHE A 100
LEU A 136
ALA A 137
LEU A 139
 None
 0.61A 5y7pB-5hkeA:
52.3		 5y7pB-5hkeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		5 ILE A 182
LEU A 377
LEU A 431
ALA A 432
LEU A 474
 None
 1.14A 5y7pB-5iheA:
undetectable		 5y7pB-5iheA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 LEU A 396
LEU A 349
LEU A 337
ALA A 343
LEU A 444
 None
 1.25A 5y7pB-5ikpA:
undetectable		 5y7pB-5ikpA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixu UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF07978
(NIPSNAP) 		5 LEU A  33
TYR A  28
ILE A  88
PHE A  84
LEU A  75
 None
 0.89A 5y7pB-5ixuA:
undetectable		 5y7pB-5ixuA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp7 ACETYL-COA
ACETYLTRANSFERASE

(Bacillus
subtilis) 		no annotation 5 ILE H 102
LEU H 259
PHE H 257
ALA H  41
LEU H  38
 None
 1.17A 5y7pB-5lp7H:
undetectable		 5y7pB-5lp7H:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L25

(Mycolicibacterium
smegmatis) 		PF01386
(Ribosomal_L25p)
PF14693
(Ribosomal_TL5_C) 		5 ILE W  92
ASN W   9
LEU W  79
ALA W  65
LEU W  67
 None
 1.25A 5y7pB-5o60W:
undetectable		 5y7pB-5o60W:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oar BETA-HEXOSAMINIDASE
BETA-HEXOSAMINIDASE

(Aspergillus
oryzae;
Aspergillus
oryzae) 		no annotation
no annotation 		5 ILE B 264
LEU B 213
ASN B 571
LEU A  24
LEU B 568
 None
 1.21A 5y7pB-5oarB:
undetectable		 5y7pB-5oarB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Homo sapiens) 		PF04084
(ORC2) 		5 LEU E 323
LEU E 297
PHE E 298
LEU E 444
LEU E 305
 None
 1.07A 5y7pB-5uj8E:
undetectable		 5y7pB-5uj8E:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy0 CYTOSOLIC
NIFE-HYDROGENASE,
ALPHA SUBUNIT

(Thermococcus
kodakarensis) 		no annotation 5 LEU A 189
ILE A 101
LEU A 283
ALA A 287
LEU A 312
 None
 1.24A 5y7pB-5yy0A:
undetectable		 5y7pB-5yy0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b92 U6 SMALL NUCLEAR RNA
(ADENINE-(43)-N(6))-
METHYLTRANSFERASE

(Homo sapiens) 		no annotation 5 ILE A  68
LEU A  60
PHE A  64
LEU A 124
ALA A 122
 None
 1.19A 5y7pB-6b92A:
undetectable		 5y7pB-6b92A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw5 RIBOKINASE

(Cryptococcus
neoformans) 		no annotation 5 LEU A 293
ILE A 235
LEU A 184
PHE A 162
ALA A 276
 None
 1.14A 5y7pB-6cw5A:
undetectable		 5y7pB-6cw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 5 LEU A 252
ILE A 238
LEU A 209
LEU A 216
ALA A 221
 None
 1.21A 5y7pB-6etiA:
undetectable		 5y7pB-6etiA:
undetectable