SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y2T_B_8LXB501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 185
PHE A 189
MET A 278
LEU A 214
 None
 1.08A 5y2tB-1bf2A:
0.0		 5y2tB-1bf2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLU A 544
PHE A 206
HIS A 127
LEU A 176
 None
 1.11A 5y2tB-1bhgA:
0.0		 5y2tB-1bhgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 PHE A 164
SER A  38
HIS A  30
PHE A 167
 None
 1.04A 5y2tB-1brtA:
0.0		 5y2tB-1brtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpg GLUTAMIC ACID
SPECIFIC PROTEASE

(Streptomyces
griseus) 		no annotation 4 HIS A 228
PHE A 200
SER A 159
LEU A 120
 None
 1.07A 5y2tB-1hpgA:
undetectable		 5y2tB-1hpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		4 GLU A  46
PHE A 132
PHE A 118
LEU A 160
 None
 1.05A 5y2tB-1i4wA:
0.0		 5y2tB-1i4wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 HIS A  11
PHE A 218
PHE A  34
MET A  35
 None
 1.11A 5y2tB-1k1xA:
0.0		 5y2tB-1k1xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvm CATALYTIC DOMAIN OF
THE NUCLEAR
INCLUSION PROTEIN A
(NIA)

(Tobacco etch
virus) 		PF00863
(Peptidase_C4) 		4 GLU A  24
PHE A  64
PHE A  91
MET A  87
 None
 1.09A 5y2tB-1lvmA:
undetectable		 5y2tB-1lvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 GLU A 243
PHE A 153
PHE A 120
LEU A  87
 None
 1.05A 5y2tB-1mnnA:
undetectable		 5y2tB-1mnnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLU A 577
SER A 445
HIS A 440
LEU A 383
 None
 0.94A 5y2tB-1n7rA:
0.6		 5y2tB-1n7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbb CYTOCHROME C'

(Rhodobacter
capsulatus) 		PF01322
(Cytochrom_C_2) 		4 GLU A  69
SER A  20
MET A  88
LEU A 111
 HEM  A 130 (-2.9A)
None
HEM  A 130 ( 4.2A)
None
 0.97A 5y2tB-1nbbA:
undetectable		 5y2tB-1nbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		4 HIS A 206
PHE A 294
PHE A 263
LEU A 258
 None
 1.06A 5y2tB-1phzA:
0.0		 5y2tB-1phzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgt PROTEIN (HBV CAPSID
PROTEIN)

(Hepatitis B
virus) 		no annotation 4 PHE C  24
SER C 106
PHE C  23
LEU C  16
 None
 1.03A 5y2tB-1qgtC:
undetectable		 5y2tB-1qgtC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 435
PHE A 430
MET A 425
LEU A 244
 None
 1.03A 5y2tB-1ulzA:
0.0		 5y2tB-1ulzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 GLU A 271
PHE A 375
PHE A  43
LEU A  57
 None
 1.04A 5y2tB-1ur4A:
undetectable		 5y2tB-1ur4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 GLU A  29
PHE A 198
PHE A 447
LEU A 436
 None
 0.91A 5y2tB-1v4gA:
undetectable		 5y2tB-1v4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		4 GLU A  21
PHE A 118
MET A 119
LEU A 130
 None
 1.01A 5y2tB-1vffA:
undetectable		 5y2tB-1vffA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wid DNA-BINDING PROTEIN
RAV1

(Arabidopsis
thaliana) 		PF02362
(B3) 		4 HIS A 213
PHE A 274
PHE A 230
LEU A 203
 None
 1.09A 5y2tB-1widA:
undetectable		 5y2tB-1widA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 HIS B 159
PHE B  27
PHE B 106
LEU B  44
 None
 1.02A 5y2tB-1zunB:
undetectable		 5y2tB-1zunB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLU A 455
PHE A 474
SER A 428
PHE A 520
 None
 1.02A 5y2tB-2c9kA:
undetectable		 5y2tB-2c9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 HIS A 368
PHE A 358
SER A 409
LEU A 344
 None
 1.10A 5y2tB-2gmhA:
undetectable		 5y2tB-2gmhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 GLU A 113
PHE A 183
PHE A 177
MET A 173
 None
 1.10A 5y2tB-2ocaA:
undetectable		 5y2tB-2ocaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		4 GLU A 180
HIS A  81
PHE A 175
LEU A  99
 None
ZN  A 500 ( 3.3A)
None
GUN  A 600 (-4.2A)
 0.97A 5y2tB-2oodA:
undetectable		 5y2tB-2oodA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooj HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF11528
(DUF3224) 		4 HIS A 102
PHE A 132
MET A   3
LEU A  73
 None
 1.07A 5y2tB-2oojA:
undetectable		 5y2tB-2oojA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz8 MLL7089 PROTEIN

(Mesorhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 HIS A  67
PHE A  65
SER A  72
LEU A  36
 None
 1.04A 5y2tB-2oz8A:
undetectable		 5y2tB-2oz8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 GLU A 278
PHE A 154
SER A 219
MET A  36
 None
 1.08A 5y2tB-2q6zA:
undetectable		 5y2tB-2q6zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		4 GLU A 280
HIS A 218
PHE A 136
LEU A 150
 ZN  A 400 (-2.5A)
XLS  A 401 (-4.3A)
None
None
 0.97A 5y2tB-2qw5A:
undetectable		 5y2tB-2qw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		4 GLU A  15
SER A  51
HIS A  81
LEU A 286
 None
 0.93A 5y2tB-2vp3A:
undetectable		 5y2tB-2vp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 365
PHE A 125
PHE A  88
LEU A 272
 None
 0.89A 5y2tB-2xf2A:
undetectable		 5y2tB-2xf2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4r CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Thermotoga
maritima) 		PF00308
(Bac_DnaA) 		4 PHE A 134
SER A 168
PHE A 252
LEU A 241
 None
 1.08A 5y2tB-2z4rA:
undetectable		 5y2tB-2z4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		4 GLU A 187
HIS A 227
PHE A 126
LEU A  41
 None
 0.97A 5y2tB-2zu0A:
undetectable		 5y2tB-2zu0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8r PUTATIVE
UNCHARACTERIZED
PROTEIN

(Oryza sativa) 		PF08414
(NADPH_Ox)
PF13499
(EF-hand_7) 		4 GLU A 256
PHE A 199
PHE A 182
LEU A 213
 None
 0.90A 5y2tB-3a8rA:
undetectable		 5y2tB-3a8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 259
PHE A 282
PHE A 363
MET A 364
LEU A 453
 None
MC5  A   1 (-4.4A)
None
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
 1.00A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 259
PHE A 282
SER A 289
HIS A 323
MET A 364
 None
MC5  A   1 (-4.4A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 (-3.7A)
 0.79A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 259
PHE A 282
SER A 289
MET A 364
LEU A 453
 None
MC5  A   1 (-4.4A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
 0.89A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdv UNCHARACTERIZED
PROTEIN DUF1234

(Pectobacterium
atrosepticum) 		PF06821
(Ser_hydrolase) 		4 GLU A 166
HIS A  80
PHE A  82
LEU A  57
 None
 1.07A 5y2tB-3bdvA:
undetectable		 5y2tB-3bdvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 GLU A  20
PHE A  74
SER A 355
LEU A 381
 None
 1.08A 5y2tB-3d45A:
undetectable		 5y2tB-3d45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0c TRANSCRIPTIONAL
REGULATOR

(Cytophaga
hutchinsonii) 		PF00440
(TetR_N) 		4 HIS A 101
PHE A  99
SER A 106
LEU A 172
 None
 1.02A 5y2tB-3f0cA:
undetectable		 5y2tB-3f0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2v PREC/CORE PROTEIN

(Hepatitis B
virus) 		no annotation 4 PHE C  24
SER C 106
PHE C  23
LEU C  16
 None
 0.98A 5y2tB-3j2vC:
undetectable		 5y2tB-3j2vC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		4 HIS A 319
PHE A 324
SER A 311
LEU A 372
 ACT  A 382 (-4.5A)
None
None
None
 1.09A 5y2tB-3ke3A:
undetectable		 5y2tB-3ke3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 GLU A 340
HIS A 223
PHE A 216
LEU A 149
 None
 1.10A 5y2tB-3kehA:
undetectable		 5y2tB-3kehA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		4 GLU A 109
HIS A 382
SER A 375
LEU A 170
 None
 0.80A 5y2tB-3lkbA:
undetectable		 5y2tB-3lkbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 GLU A  26
SER A  97
PHE A 404
LEU A 256
 None
 0.92A 5y2tB-3lq1A:
undetectable		 5y2tB-3lq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		4 HIS A 258
PHE A 145
SER A 138
LEU A 213
 None
 1.07A 5y2tB-3m1aA:
undetectable		 5y2tB-3m1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 GLU B 509
HIS A 207
PHE B 515
MET B 541
 None
 0.97A 5y2tB-3pcoB:
undetectable		 5y2tB-3pcoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 153
PHE A 155
SER A 132
LEU A 211
 QHF  A   1 ( 3.0A)
None
None
None
 1.06A 5y2tB-3q2hA:
undetectable		 5y2tB-3q2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLU A 342
SER A 240
PHE A 315
LEU A 265
 None
 1.07A 5y2tB-3tqiA:
undetectable		 5y2tB-3tqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 GLU A 198
SER A 102
MET A  52
LEU A 120
 None
 1.06A 5y2tB-3tr1A:
undetectable		 5y2tB-3tr1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Eptatretus
burgeri;
Danio rerio) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 250
SER A 266
PHE A 286
LEU A 261
 None
 1.00A 5y2tB-3v44A:
undetectable		 5y2tB-3v44A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 304
HIS A 279
PHE A 305
LEU A 341
 None
 1.08A 5y2tB-3v7nA:
undetectable		 5y2tB-3v7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 PHE A 224
HIS A 179
PHE A 228
LEU A  82
 None
UNL  A 436 ( 3.9A)
BEZ  A 430 ( 4.6A)
None
 0.98A 5y2tB-3v7pA:
undetectable		 5y2tB-3v7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLU A  64
PHE A 166
SER A 344
LEU A 104
 None
 1.10A 5y2tB-3v8uA:
undetectable		 5y2tB-3v8uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 HIS A 335
PHE A 311
PHE A 303
LEU A 267
 None
 1.08A 5y2tB-3vcyA:
undetectable		 5y2tB-3vcyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLU A 636
HIS A 916
SER A 921
LEU A 847
 RAM  A1202 (-3.1A)
RAM  A1202 (-4.0A)
None
None
 1.07A 5y2tB-3w5nA:
undetectable		 5y2tB-3w5nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 PHE A 264
PHE A 282
MET A 385
LEU A 293
 None
 1.04A 5y2tB-4aioA:
undetectable		 5y2tB-4aioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 403
PHE A 163
PHE A 126
LEU A 310
 None
 0.81A 5y2tB-4aj9A:
undetectable		 5y2tB-4aj9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 GLU A  52
HIS A 140
PHE A 179
PHE A 104
 None
 1.02A 5y2tB-4bg2A:
undetectable		 5y2tB-4bg2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3s IMINE REDUCTASE

(Nocardiopsis
halophila) 		PF03446
(NAD_binding_2) 		4 GLU A 148
PHE A 139
PHE A 137
LEU A 177
 None
 1.08A 5y2tB-4d3sA:
undetectable		 5y2tB-4d3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 GLU A1283
PHE A1045
SER A1129
LEU A1084
 None
 0.93A 5y2tB-4fbqA:
undetectable		 5y2tB-4fbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 4 GLU B 283
PHE B  45
SER B 129
LEU B  84
 None
 1.00A 5y2tB-4fcxB:
undetectable		 5y2tB-4fcxB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		4 PHE A 164
SER A  38
HIS A  30
PHE A 167
 None
 1.08A 5y2tB-4iq4A:
undetectable		 5y2tB-4iq4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 PHE A  51
SER A 174
HIS A 137
PHE A  52
 INS  A 401 (-3.5A)
INS  A 401 (-2.5A)
None
None
 0.97A 5y2tB-4irxA:
undetectable		 5y2tB-4irxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		4 GLU A 227
HIS A 273
PHE A 271
HIS A  12
 None
 1.08A 5y2tB-4novA:
undetectable		 5y2tB-4novA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E

(Aeropyrum
pernix) 		PF01040
(UbiA) 		4 HIS A 126
PHE A 174
HIS A   8
PHE A 258
 None
None
GST  A 301 ( 4.9A)
None
 0.95A 5y2tB-4od5A:
undetectable		 5y2tB-4od5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 SER A  44
HIS A 735
PHE A 801
LEU A 721
 None
 1.07A 5y2tB-4ogcA:
undetectable		 5y2tB-4ogcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		4 GLU A1545
HIS A1345
PHE A1343
SER A1350
 None
 0.96A 5y2tB-4p1tA:
undetectable		 5y2tB-4p1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 GLU A  88
PHE A 302
SER A 219
PHE A 303
 None
 1.10A 5y2tB-4p4sA:
undetectable		 5y2tB-4p4sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 GLU B  88
PHE B 302
SER B 219
PHE B 303
 None
 1.09A 5y2tB-4p4sB:
undetectable		 5y2tB-4p4sB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120) 		PF05067
(Mn_catalase) 		4 GLU A   7
HIS A   4
PHE A  66
LEU A  40
 None
 0.93A 5y2tB-4r42A:
undetectable		 5y2tB-4r42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 365
PHE A 367
SER A 344
LEU A 424
 ZN  A 501 ( 3.3A)
None
None
None
 1.11A 5y2tB-4wk7A:
undetectable		 5y2tB-4wk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpe CYTOKINESIS PROTEIN
2

(Saccharomyces
cerevisiae) 		PF00611
(FCH) 		4 PHE A  38
SER A 235
PHE A  37
LEU A 228
 None
 1.08A 5y2tB-4wpeA:
undetectable		 5y2tB-4wpeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsh UROPORPHYRINOGEN
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF01208
(URO-D) 		4 GLU A 266
PHE A 145
SER A 210
MET A  26
 None
None
SO4  A 407 ( 4.7A)
SO4  A 407 ( 4.6A)
 1.01A 5y2tB-4wshA:
undetectable		 5y2tB-4wshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		4 PHE A  75
SER A  15
HIS A  89
LEU A  60
 None
 0.89A 5y2tB-4yisA:
undetectable		 5y2tB-4yisA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN

(Homo sapiens) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		4 GLU A 284
PHE A 279
PHE A 278
LEU A  98
 None
 1.05A 5y2tB-5bugA:
undetectable		 5y2tB-5bugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus;
Influenza C
virus) 		PF00603
(Flu_PA)
PF00602
(Flu_PB1) 		4 PHE B  61
SER A 198
PHE B 403
LEU B 224
 None
 0.85A 5y2tB-5d9aB:
undetectable		 5y2tB-5d9aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 HIS A  20
PHE A  69
PHE A  42
LEU A 348
 HIS  A  20 ( 1.0A)
PHE  A  69 ( 1.3A)
PHE  A  42 ( 1.3A)
LEU  A 348 ( 0.6A)
 1.11A 5y2tB-5ec3A:
undetectable		 5y2tB-5ec3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 HIS A2024
PHE A2023
PHE A2047
MET A2051
 None
 1.11A 5y2tB-5fu7A:
undetectable		 5y2tB-5fu7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 HIS A2282
PHE A2284
HIS A2114
LEU A2220
 None
 1.03A 5y2tB-5fu7A:
undetectable		 5y2tB-5fu7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 PHE E 172
SER E  64
MET E 177
LEU E 116
 None
 1.09A 5y2tB-5g06E:
undetectable		 5y2tB-5g06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 389
PHE A 375
MET A 374
LEU A 412
 None
 1.06A 5y2tB-5gs0A:
undetectable		 5y2tB-5gs0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 GLU A 515
PHE A 388
SER A 431
LEU A 492
 None
 1.08A 5y2tB-5h5mA:
undetectable		 5y2tB-5h5mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE

(Mus musculus) 		PF03079
(ARD) 		4 GLU A  93
PHE A 135
PHE A  84
LEU A 137
 None
69O  A 202 (-3.1A)
69O  A 202 (-3.6A)
None
 1.11A 5y2tB-5i93A:
undetectable		 5y2tB-5i93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 GLU A 258
PHE A 317
SER A 363
LEU A 370
 None
 0.75A 5y2tB-5iwzA:
undetectable		 5y2tB-5iwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 4 GLU A 176
HIS A 148
MET A 218
LEU A  42
 None
CRO  A  66 ( 3.8A)
None
None
 1.06A 5y2tB-5mseA:
undetectable		 5y2tB-5mseA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 GLU A 339
PHE A 243
SER A 192
PHE A 265
 None
 1.07A 5y2tB-5ns8A:
undetectable		 5y2tB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLU A2344
HIS A2689
PHE A2682
LEU A2632
 MG  A4803 ( 3.1A)
None
None
None
 1.02A 5y2tB-5nugA:
undetectable		 5y2tB-5nugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 GLU A 321
PHE A 732
PHE A 718
MET A 717
 None
 0.85A 5y2tB-5svcA:
undetectable		 5y2tB-5svcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 HIS A 352
PHE A 433
HIS A 375
PHE A 368
 None
 1.08A 5y2tB-5u70A:
undetectable		 5y2tB-5u70A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 GLU A 395
HIS A 342
SER A 332
HIS A  67
 None
 1.01A 5y2tB-5uamA:
undetectable		 5y2tB-5uamA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v91 FOSFOMYCIN
RESISTANCE PROTEIN

(Klebsiella
pneumoniae) 		PF00903
(Glyoxalase) 		4 HIS A 110
PHE A  21
MET A  28
LEU A  84
 None
 1.07A 5y2tB-5v91A:
undetectable		 5y2tB-5v91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3

(Escherichia
coli) 		PF00903
(Glyoxalase) 		4 HIS A 110
PHE A  21
MET A  28
LEU A  84
 None
 1.09A 5y2tB-5vb0A:
undetectable		 5y2tB-5vb0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 HIS A 338
PHE A 314
PHE A 306
LEU A 270
 None
 1.08A 5y2tB-5wi5A:
undetectable		 5y2tB-5wi5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 GLU A 103
HIS A 178
PHE A 202
LEU A  55
 None
 1.08A 5y2tB-5wt4A:
undetectable		 5y2tB-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4r S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 HIS A 298
PHE A 228
PHE A 183
LEU A 187
 None
 1.11A 5y2tB-5x4rA:
undetectable		 5y2tB-5x4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 HIS A 298
PHE A 228
PHE A 183
LEU A 187
 None
 1.11A 5y2tB-5x59A:
undetectable		 5y2tB-5x59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 PHE A 233
SER A 207
PHE A 258
LEU A 218
 None
 0.95A 5y2tB-5zqeA:
undetectable		 5y2tB-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 PHE 2 686
SER 2 545
PHE 2 665
LEU 2 605
 None
 1.05A 5y2tB-5zvs2:
undetectable		 5y2tB-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Danio rerio) 		no annotation 4 PHE A 250
SER A 266
PHE A 286
LEU A 261
 None
 0.99A 5y2tB-6bxaA:
undetectable		 5y2tB-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 HIS A 722
PHE A 727
SER A 779
LEU A 800
 None
 1.07A 5y2tB-6ez8A:
undetectable		 5y2tB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 HIS A 156
PHE A  79
PHE A 138
MET A 129
 None
 1.00A 5y2tB-6f91A:
undetectable		 5y2tB-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi) 		no annotation 4 GLU A 208
HIS A 330
PHE A 203
LEU A 166
 MG  A 500 ( 2.7A)
CAP  A 501 (-3.8A)
None
None
 1.08A 5y2tB-6ftlA:
undetectable		 5y2tB-6ftlA:
undetectable