SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y2T_B_8LXB501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aih HP1 INTEGRASE

(Haemophilus
virus HP1) 		PF00589
(Phage_integrase) 		5 ILE A 239
ILE A 179
TYR A 180
LEU A 183
ILE A 200
 None
 1.05A 5y2tB-1aihA:
undetectable		 5y2tB-1aihA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ILE A 448
GLN A 430
ILE A 188
TYR A 138
ILE A 151
 None
 1.05A 5y2tB-1hcyA:
0.0		 5y2tB-1hcyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		5 LEU K  62
ARG K  82
ILE K  51
ILE K 207
ILE K  28
 None
 1.21A 5y2tB-1oxxK:
undetectable		 5y2tB-1oxxK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103

(Geobacillus
stearothermophilus) 		PF02645
(DegV) 		5 LEU A  83
ILE A  85
CYH A 154
LEU A 281
HIS A 159
 None
 1.19A 5y2tB-1pzxA:
0.0		 5y2tB-1pzxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU B 300
ILE B 304
TYR B 228
LEU B 251
HIS B 276
 None
 1.15A 5y2tB-1qs0B:
0.0		 5y2tB-1qs0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9c GLUTATHIONE
TRANSFERASE

(Mesorhizobium
loti) 		PF00903
(Glyoxalase) 		5 LEU A   5
ILE A  52
TYR A  82
LEU A 119
ILE A  70
 None
 1.16A 5y2tB-1r9cA:
undetectable		 5y2tB-1r9cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		6 LEU A 128
ARG A 131
ILE A 100
ILE A  28
ILE A  91
MET A  88
 None
 1.16A 5y2tB-1txgA:
0.0		 5y2tB-1txgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfg POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol) 		5 LEU A 304
ILE A 338
ILE A 254
TYR A 256
LEU A 259
 None
 1.06A 5y2tB-1vfgA:
undetectable		 5y2tB-1vfgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc5 ADENYLATE CYCLASE

(Arthrospira
platensis) 		PF00211
(Guanylate_cyc) 		5 ILE A1120
CYH A1118
GLN A1152
LEU A1090
ILE A1195
 None
None
MG  A2000 ( 4.6A)
None
None
 1.16A 5y2tB-1wc5A:
undetectable		 5y2tB-1wc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc5 ADENYLATE CYCLASE

(Arthrospira
platensis) 		PF00211
(Guanylate_cyc) 		5 LEU A1037
PHE A1058
ILE A1018
GLN A1152
ILE A1160
 None
None
None
MG  A2000 ( 4.6A)
None
 1.17A 5y2tB-1wc5A:
undetectable		 5y2tB-1wc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 LEU A 199
PHE A 179
ILE A 279
LEU A 282
ILE A 246
 None
 1.20A 5y2tB-1xp3A:
0.0		 5y2tB-1xp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 LEU A  58
ILE A  27
TYR A  96
LEU A  93
ILE A  53
 None
 1.21A 5y2tB-1z9dA:
undetectable		 5y2tB-1z9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ARG A1157
ILE A1164
ILE A1096
TYR A1092
LEU A1093
 None
 1.10A 5y2tB-2bzlA:
undetectable		 5y2tB-2bzlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		5 LEU A 148
ILE A 159
GLN A 134
LEU A 283
ILE A 138
 None
 1.10A 5y2tB-2cavA:
undetectable		 5y2tB-2cavA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		5 LEU A 308
ILE A 105
GLN A 139
ILE A 114
ILE A 324
 None
 0.94A 5y2tB-2f8lA:
undetectable		 5y2tB-2f8lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 ILE A 522
GLN A 524
ILE A 495
LEU A 533
ILE A 505
 None
 1.08A 5y2tB-2hnzA:
undetectable		 5y2tB-2hnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 388
PHE A 407
TYR A 446
LEU A 449
HIS A 298
 None
EDO  A1474 ( 4.8A)
None
EDO  A1473 (-4.4A)
None
 1.10A 5y2tB-2jiiA:
undetectable		 5y2tB-2jiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l22 MUPIROCIN DIDOMAIN
ACYL CARRIER PROTEIN

(Pseudomonas
fluorescens) 		PF00550
(PP-binding) 		5 PHE A 135
GLN A 147
TYR A 113
LEU A 114
HIS A 155
 None
 1.18A 5y2tB-2l22A:
undetectable		 5y2tB-2l22A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		5 GLN A 122
ILE A 146
TYR A 147
LEU A 150
ILE A 102
 None
 1.21A 5y2tB-2laoA:
undetectable		 5y2tB-2laoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 LEU A 987
PHE A 941
ARG A1023
LEU A1035
ILE A1019
 None
 1.11A 5y2tB-2nz9A:
undetectable		 5y2tB-2nz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 247
ARG A 271
ILE A 272
CYH A 276
GLN A 277
ILE A 317
HIS A 440
 None
None
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
 0.98A 5y2tB-2p54A:
34.2		 5y2tB-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 247
ILE A 272
CYH A 276
GLN A 277
ILE A 317
LEU A 321
HIS A 440
 None
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
735  A 469 ( 4.3A)
735  A 469 (-4.0A)
 0.75A 5y2tB-2p54A:
34.2		 5y2tB-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 ILE A  21
ILE A  55
TYR A  61
ILE A  44
HIS A  18
 None
 1.22A 5y2tB-2p9bA:
undetectable		 5y2tB-2p9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		5 LEU A 160
ILE A  85
ILE A 193
LEU A 175
ILE A 178
 None
 1.18A 5y2tB-2pbfA:
undetectable		 5y2tB-2pbfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 LEU A 519
GLN A 348
ILE A 398
LEU A 394
ILE A 358
 None
 1.13A 5y2tB-2po4A:
undetectable		 5y2tB-2po4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q22 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF08854
(DUF1824) 		5 ILE A 125
CYH A 117
GLN A 118
TYR A  77
LEU A  75
 None
 1.21A 5y2tB-2q22A:
undetectable		 5y2tB-2q22A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv CARBON CATABOLITE
DEREPRESSING PROTEIN
KINASE

(Saccharomyces
cerevisiae) 		PF16579
(AdenylateSensor) 		5 PHE A 586
GLN A 571
ILE A 522
TYR A 523
LEU A 526
 None
 1.05A 5y2tB-2qlvA:
undetectable		 5y2tB-2qlvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		5 LEU A  78
ILE A  20
GLN A  35
ILE A  44
LEU A  48
 None
 0.96A 5y2tB-2wduA:
undetectable		 5y2tB-2wduA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 PHE A 119
ARG A 117
ILE A  77
LEU A 148
ILE A  28
 None
 1.23A 5y2tB-2xkaA:
undetectable		 5y2tB-2xkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 LEU A   3
ILE A 283
LEU A  40
ILE A  10
HIS A  95
 None
 1.20A 5y2tB-2yh2A:
undetectable		 5y2tB-2yh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF16565
(MIT_C) 		5 LEU A 141
PHE A 199
ILE A 151
ILE A 192
ILE A 197
 None
 1.17A 5y2tB-2ymbA:
undetectable		 5y2tB-2ymbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		5 LEU A 524
PHE A 467
ILE A 572
ILE A 346
LEU A 332
 None
 1.21A 5y2tB-2zuyA:
undetectable		 5y2tB-2zuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 255
ARG A 280
ILE A 281
CYH A 285
GLN A 286
ILE A 326
TYR A 327
LEU A 330
ILE A 341
MET A 348
HIS A 449
 None
None
MC5  A   1 ( 4.8A)
MC5  A   1 (-3.6A)
None
MC5  A   1 ( 4.9A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.9A)
 0.61A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
ILE A 281
GLN A 283
ILE A 341
MET A 348
 None
MC5  A   1 ( 4.8A)
None
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
 1.08A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8g PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Shigella
flexneri) 		PF05068
(MtlR) 		5 LEU B  13
ILE B  29
GLN B  36
ILE B  74
LEU B  71
 None
 1.19A 5y2tB-3c8gB:
undetectable		 5y2tB-3c8gB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 LEU A 235
ILE A 144
ILE A 208
MET A 204
HIS A 109
 None
None
None
None
BEZ  A 261 (-3.7A)
 1.21A 5y2tB-3ccfA:
undetectable		 5y2tB-3ccfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 255
CYH A 285
GLN A 286
ILE A 326
LEU A 330
HIS A 449
 None
L41  A 501 (-3.5A)
None
None
L41  A 501 (-4.9A)
L41  A 501 (-3.9A)
 0.75A 5y2tB-3d5fA:
34.3		 5y2tB-3d5fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 ILE D 281
ILE D 326
TYR D 327
LEU D 330
ILE D 341
MET D 348
HIS D 449
 PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
 0.76A 5y2tB-3dzuD:
34.2		 5y2tB-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 LEU D 255
ARG D 280
ILE D 281
GLN D 286
ILE D 326
LEU D 330
ILE D 341
MET D 348
 None
None
PLB  D 701 (-4.6A)
None
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
 0.67A 5y2tB-3dzuD:
34.2		 5y2tB-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 LEU D 255
ARG D 280
ILE D 281
ILE D 326
LEU D 330
ILE D 341
MET D 348
HIS D 449
 None
None
PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
 0.76A 5y2tB-3dzuD:
34.2		 5y2tB-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 561
ILE A 468
LEU A 335
ILE A 481
HIS A 347
 None
 1.21A 5y2tB-3e9yA:
undetectable		 5y2tB-3e9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum) 		PF02645
(DegV) 		5 LEU A 163
ILE A 152
ILE A  68
LEU A  99
MET A 169
 None
None
None
PLM  A 275 ( 4.6A)
None
 1.02A 5y2tB-3eglA:
undetectable		 5y2tB-3eglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		5 LEU A 216
ILE A 214
CYH A 257
LEU A  23
ILE A 107
 None
 1.07A 5y2tB-3lhlA:
undetectable		 5y2tB-3lhlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A 665
CYH A 762
ILE A 789
ILE A 854
HIS A 782
 None
 0.98A 5y2tB-3lltA:
undetectable		 5y2tB-3lltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		5 LEU A 132
ARG A 167
ILE A 129
ILE A 192
LEU A 142
 None
 1.18A 5y2tB-3lwsA:
undetectable		 5y2tB-3lwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 LEU A 300
PHE A 177
ILE A 203
ILE A 146
HIS A 320
 None
 1.13A 5y2tB-3sopA:
undetectable		 5y2tB-3sopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 LEU A 300
PHE A 177
ILE A 203
ILE A 146
TYR A 150
 None
 1.20A 5y2tB-3sopA:
undetectable		 5y2tB-3sopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae) 		PF07571
(TAF6_C) 		5 LEU A 244
ILE A 240
ILE A 175
TYR A 171
ILE A 205
 None
 1.06A 5y2tB-4atgA:
undetectable		 5y2tB-4atgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		5 LEU A 261
CYH A 104
GLN A 103
ILE A  83
ILE A  56
 None
 1.08A 5y2tB-4aurA:
undetectable		 5y2tB-4aurA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		6 PHE A2030
ILE A1988
GLN A1983
ILE A1978
ILE A2026
MET A2009
 None
 1.30A 5y2tB-4by6A:
undetectable		 5y2tB-4by6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 PHE A 347
ILE A 228
CYH A 307
GLN A 308
ILE A 343
 None
None
None
0H7  A 502 (-3.1A)
None
 1.11A 5y2tB-4da5A:
undetectable		 5y2tB-4da5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 LEU A 283
ILE A 188
ILE A 168
TYR A 125
LEU A 112
 None
None
CAF  A 169 ( 3.9A)
None
None
 1.22A 5y2tB-4h5uA:
undetectable		 5y2tB-4h5uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		5 LEU A  48
ILE A 275
ILE A 330
LEU A 331
ILE A 285
 None
 0.98A 5y2tB-4il5A:
undetectable		 5y2tB-4il5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 PHE A 736
ILE A 691
ILE A 729
LEU A 746
ILE A 742
 None
 1.15A 5y2tB-4j3bA:
undetectable		 5y2tB-4j3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		5 LEU A 301
ILE A 303
ILE A 439
TYR A 440
HIS A 378
 None
 1.14A 5y2tB-4jo0A:
undetectable		 5y2tB-4jo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 5 LEU B 243
GLN B  90
ILE B 182
LEU B 183
ILE B 207
 None
None
LMT  B 302 ( 4.0A)
None
None
 1.19A 5y2tB-4mkiB:
undetectable		 5y2tB-4mkiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 ILE A1241
CYH A1285
GLN A1284
ILE A1373
LEU A1276
 None
HG  A2205 (-3.5A)
None
None
None
 1.19A 5y2tB-4o9xA:
undetectable		 5y2tB-4o9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		5 LEU B  91
ILE B 112
GLN B 118
ILE B 169
LEU B 173
 None
 1.23A 5y2tB-4ol0B:
undetectable		 5y2tB-4ol0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		5 LEU A 304
ILE A 302
ILE A 257
LEU A 248
ILE A 241
 None
 1.23A 5y2tB-4on1A:
undetectable		 5y2tB-4on1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR

(Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 LEU A 142
ILE A 118
TYR A 102
LEU A 105
ILE A 132
 None
 1.15A 5y2tB-4pbvA:
undetectable		 5y2tB-4pbvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 LEU A 231
ILE A 210
ILE A  15
TYR A 247
ILE A 272
 None
 1.17A 5y2tB-4pzvA:
undetectable		 5y2tB-4pzvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5q GLUTATHIONE
S-TRANSFERASE

(Dermatophagoides
pteronyssinus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  54
ILE A  65
GLN A   3
TYR A  85
LEU A  81
 None
 1.21A 5y2tB-4q5qA:
undetectable		 5y2tB-4q5qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PHE A 333
TYR A 273
LEU A 274
ILE A 262
MET A 298
 None
 1.13A 5y2tB-4v2pA:
undetectable		 5y2tB-4v2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00144
(Beta-lactamase) 		5 LEU A  54
GLN A 311
ILE A 305
TYR A 301
LEU A 339
 None
 1.21A 5y2tB-4x68A:
undetectable		 5y2tB-4x68A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yuf CORB

(Corallococcus
coralloides) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PHE A 333
TYR A 273
LEU A 274
ILE A 262
MET A 298
 None
 1.14A 5y2tB-4yufA:
undetectable		 5y2tB-4yufA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx8 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 LEU A 187
ILE A 201
GLN A 218
ILE A  97
LEU A  94
 None
 1.02A 5y2tB-4yx8A:
undetectable		 5y2tB-4yx8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9b POLYHEDRIN

(Cypovirus 1) 		PF05865
(Cypo_polyhedrin) 		5 LEU A 168
ILE A 109
ILE A 225
TYR A 224
LEU A 220
 None
 1.04A 5y2tB-5a9bA:
undetectable		 5y2tB-5a9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9p POLYHEDRIN

(Operophtera
brumata
cypovirus 18) 		PF05865
(Cypo_polyhedrin) 		5 LEU A 168
ILE A 109
ILE A 225
TYR A 224
LEU A 220
 None
 0.92A 5y2tB-5a9pA:
undetectable		 5y2tB-5a9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bra PUTATIVE PERIPLASMIC
BINDING PROTEIN WITH
SUBSTRATE RIBOSE

(Ochrobactrum
anthropi) 		PF13407
(Peripla_BP_4) 		5 PHE A  67
ILE A 128
ILE A  91
LEU A  95
ILE A  45
 None
 1.05A 5y2tB-5braA:
undetectable		 5y2tB-5braA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 LEU A  85
ILE A  81
GLN A 294
LEU A  50
ILE A 258
 None
 1.23A 5y2tB-5c6uA:
undetectable		 5y2tB-5c6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejh NAD KINASE 1

(Listeria
monocytogenes) 		PF01513
(NAD_kinase) 		5 LEU A  16
ILE A  67
ILE A  62
ILE A   5
MET A  20
 None
 1.12A 5y2tB-5ejhA:
undetectable		 5y2tB-5ejhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyg INOSITOL
MONOPHOSPHATASE

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		5 LEU A 255
PHE A 159
ILE A 241
GLN A 213
ILE A 157
 None
 1.09A 5y2tB-5eygA:
undetectable		 5y2tB-5eygA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 LEU A 110
PHE A 118
ILE A 171
LEU A 172
ILE A 179
 None
 1.17A 5y2tB-5fg3A:
undetectable		 5y2tB-5fg3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmu TRAF3-INTERACTING
PROTEIN 1

(Mus musculus) 		PF10243
(MIP-T3) 		5 GLN A 109
ILE A  38
TYR A  34
LEU A  35
ILE A  77
 None
 1.17A 5y2tB-5fmuA:
undetectable		 5y2tB-5fmuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 LEU A  12
ILE A  27
CYH A  31
LEU A 224
ILE A 218
 None
 1.23A 5y2tB-5gjaA:
undetectable		 5y2tB-5gjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5
COMPLEMENT C5

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 LEU B 575
ILE A 799
ILE B 182
TYR B 146
HIS B 129
 None
 1.17A 5y2tB-5hccB:
undetectable		 5y2tB-5hccB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 LEU A 187
ILE A 201
GLN A 218
ILE A  97
LEU A  94
 None
 0.99A 5y2tB-5id4A:
undetectable		 5y2tB-5id4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LEU A 335
ILE A 337
CYH A 348
ILE A 260
LEU A 263
 None
 1.13A 5y2tB-5jouA:
undetectable		 5y2tB-5jouA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 LEU A 203
ARG A 125
ILE A 172
TYR A 245
ILE A 184
 LEU  A 203 ( 0.5A)
ARG  A 125 ( 0.6A)
ILE  A 172 ( 0.7A)
TYR  A 245 ( 1.3A)
ILE  A 184 ( 0.4A)
 1.21A 5y2tB-5l5nA:
undetectable		 5y2tB-5l5nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pyrobaculum
calidifontis) 		PF00490
(ALAD) 		5 LEU A 321
PHE A 121
GLN A 180
LEU A 247
ILE A 253
 None
None
ZN  A 402 ( 4.9A)
None
None
 1.03A 5y2tB-5lzlA:
undetectable		 5y2tB-5lzlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 PHE A 739
GLN A 744
TYR A 783
LEU A 771
ILE A 720
 None
 0.78A 5y2tB-5m2nA:
undetectable		 5y2tB-5m2nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 LEU A 170
GLN A  90
TYR A  77
LEU A  78
ILE A 133
 None
NH3  A 504 ( 4.4A)
None
None
None
 1.16A 5y2tB-5msyA:
undetectable		 5y2tB-5msyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		5 LEU A 185
ILE A 137
ILE A 132
LEU A 133
ILE A 265
 None
 1.20A 5y2tB-5mwlA:
undetectable		 5y2tB-5mwlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ARG A 387
ILE A 388
ILE A 420
TYR A 405
ILE A 350
 None
 1.00A 5y2tB-5olpA:
undetectable		 5y2tB-5olpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ARG A 387
ILE A 420
TYR A 405
LEU A 364
ILE A 350
 None
 1.08A 5y2tB-5olpA:
undetectable		 5y2tB-5olpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 PHE A 102
ILE A  66
GLN A 110
LEU A 260
ILE A  70
 None
 1.22A 5y2tB-5tg8A:
undetectable		 5y2tB-5tg8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2i NUCLEOSIDE
DIPHOSPHATE KINASE

(Naegleria
fowleri) 		PF00334
(NDK) 		5 LEU A  10
ILE A  24
GLN A  29
ILE A 149
MET A  75
 None
 0.96A 5y2tB-5u2iA:
undetectable		 5y2tB-5u2iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A 396
GLN A 310
ILE A 245
LEU A 382
ILE A 390
 None
 1.06A 5y2tB-5u4hA:
undetectable		 5y2tB-5u4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		5 LEU A 239
ILE A 175
ILE A 188
TYR A 192
LEU A 191
 None
 1.09A 5y2tB-5u63A:
undetectable		 5y2tB-5u63A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Acinetobacter
baumannii) 		PF01116
(F_bP_aldolase) 		5 ARG A 343
ILE A 335
ILE A  70
ILE A 332
HIS A   0
 None
 1.11A 5y2tB-5u7sA:
undetectable		 5y2tB-5u7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 CYH D 441
GLN D 440
ILE D 491
ILE D 522
MET D 541
 None
 1.17A 5y2tB-5uheD:
undetectable		 5y2tB-5uheD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhb POLYHEDRIN

(Cypovirus 1) 		no annotation 5 LEU A 168
ILE A 109
ILE A 225
TYR A 224
LEU A 220
 None
 0.97A 5y2tB-5yhbA:
undetectable		 5y2tB-5yhbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 115
PHE A 127
ILE A 158
ILE A 303
ILE A 241
 None
 1.16A 5y2tB-5yk2A:
undetectable		 5y2tB-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		no annotation 5 GLN A 136
ILE A 172
LEU A 173
ILE A 180
HIS A 107
 None
 1.08A 5y2tB-5zzkA:
undetectable		 5y2tB-5zzkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 5 LEU A 405
PHE A 322
ILE A 426
ILE A 215
LEU A 307
 None
 1.21A 5y2tB-6bpcA:
undetectable		 5y2tB-6bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 LEU A  74
ILE A 176
ILE A 200
MET A 204
HIS A 179
 None
 1.22A 5y2tB-6c54A:
undetectable		 5y2tB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 LEU A  74
PHE A  60
ILE A 176
ILE A 200
MET A 204
 None
 1.21A 5y2tB-6c54A:
undetectable		 5y2tB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 ARG I 114
ILE I 110
ILE H 263
LEU H 223
ILE H 286
 None
 1.00A 5y2tB-6cfwI:
undetectable		 5y2tB-6cfwI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 PHE A  99
GLN A 104
ILE A 154
TYR A 142
ILE A  78
 None
 0.83A 5y2tB-6en4A:
undetectable		 5y2tB-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 LEU A 447
ILE A 220
GLN A 193
ILE A 154
ILE A 248
 None
 1.19A 5y2tB-6fsaA:
undetectable		 5y2tB-6fsaA:
undetectable