SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y2T_B_8LXB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aih HP1 INTEGRASE

(Haemophilus
virus HP1) 		PF00589
(Phage_integrase) 		5 ILE A 239
ILE A 179
TYR A 180
LEU A 183
ILE A 200
 None
 1.05A 5y2tB-1aihA:
undetectable		 5y2tB-1aihA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 ILE A 448
GLN A 430
ILE A 188
TYR A 138
ILE A 151
 None
 1.05A 5y2tB-1hcyA:
0.0		 5y2tB-1hcyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxx ABC TRANSPORTER, ATP
BINDING PROTEIN

(Sulfolobus
solfataricus) 		PF00005
(ABC_tran) 		5 LEU K  62
ARG K  82
ILE K  51
ILE K 207
ILE K  28
 None
 1.21A 5y2tB-1oxxK:
undetectable		 5y2tB-1oxxK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103

(Geobacillus
stearothermophilus) 		PF02645
(DegV) 		5 LEU A  83
ILE A  85
CYH A 154
LEU A 281
HIS A 159
 None
 1.19A 5y2tB-1pzxA:
0.0		 5y2tB-1pzxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU B 300
ILE B 304
TYR B 228
LEU B 251
HIS B 276
 None
 1.15A 5y2tB-1qs0B:
0.0		 5y2tB-1qs0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9c GLUTATHIONE
TRANSFERASE

(Mesorhizobium
loti) 		PF00903
(Glyoxalase) 		5 LEU A   5
ILE A  52
TYR A  82
LEU A 119
ILE A  70
 None
 1.16A 5y2tB-1r9cA:
undetectable		 5y2tB-1r9cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		6 LEU A 128
ARG A 131
ILE A 100
ILE A  28
ILE A  91
MET A  88
 None
 1.16A 5y2tB-1txgA:
0.0		 5y2tB-1txgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfg POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol) 		5 LEU A 304
ILE A 338
ILE A 254
TYR A 256
LEU A 259
 None
 1.06A 5y2tB-1vfgA:
undetectable		 5y2tB-1vfgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc5 ADENYLATE CYCLASE

(Arthrospira
platensis) 		PF00211
(Guanylate_cyc) 		5 ILE A1120
CYH A1118
GLN A1152
LEU A1090
ILE A1195
 None
None
MG  A2000 ( 4.6A)
None
None
 1.16A 5y2tB-1wc5A:
undetectable		 5y2tB-1wc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc5 ADENYLATE CYCLASE

(Arthrospira
platensis) 		PF00211
(Guanylate_cyc) 		5 LEU A1037
PHE A1058
ILE A1018
GLN A1152
ILE A1160
 None
None
None
MG  A2000 ( 4.6A)
None
 1.17A 5y2tB-1wc5A:
undetectable		 5y2tB-1wc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 LEU A 199
PHE A 179
ILE A 279
LEU A 282
ILE A 246
 None
 1.20A 5y2tB-1xp3A:
0.0		 5y2tB-1xp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 LEU A  58
ILE A  27
TYR A  96
LEU A  93
ILE A  53
 None
 1.21A 5y2tB-1z9dA:
undetectable		 5y2tB-1z9dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ARG A1157
ILE A1164
ILE A1096
TYR A1092
LEU A1093
 None
 1.10A 5y2tB-2bzlA:
undetectable		 5y2tB-2bzlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		5 LEU A 148
ILE A 159
GLN A 134
LEU A 283
ILE A 138
 None
 1.10A 5y2tB-2cavA:
undetectable		 5y2tB-2cavA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8l HYPOTHETICAL PROTEIN
LMO1582

(Listeria
monocytogenes) 		PF02384
(N6_Mtase) 		5 LEU A 308
ILE A 105
GLN A 139
ILE A 114
ILE A 324
 None
 0.94A 5y2tB-2f8lA:
undetectable		 5y2tB-2f8lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 ILE A 522
GLN A 524
ILE A 495
LEU A 533
ILE A 505
 None
 1.08A 5y2tB-2hnzA:
undetectable		 5y2tB-2hnzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 388
PHE A 407
TYR A 446
LEU A 449
HIS A 298
 None
EDO  A1474 ( 4.8A)
None
EDO  A1473 (-4.4A)
None
 1.10A 5y2tB-2jiiA:
undetectable		 5y2tB-2jiiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l22 MUPIROCIN DIDOMAIN
ACYL CARRIER PROTEIN

(Pseudomonas
fluorescens) 		PF00550
(PP-binding) 		5 PHE A 135
GLN A 147
TYR A 113
LEU A 114
HIS A 155
 None
 1.18A 5y2tB-2l22A:
undetectable		 5y2tB-2l22A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lao LYSINE, ARGININE,
ORNITHINE-BINDING
PROTEIN

(Salmonella
enterica) 		PF00497
(SBP_bac_3) 		5 GLN A 122
ILE A 146
TYR A 147
LEU A 150
ILE A 102
 None
 1.21A 5y2tB-2laoA:
undetectable		 5y2tB-2laoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 LEU A 987
PHE A 941
ARG A1023
LEU A1035
ILE A1019
 None
 1.11A 5y2tB-2nz9A:
undetectable		 5y2tB-2nz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 247
ARG A 271
ILE A 272
CYH A 276
GLN A 277
ILE A 317
HIS A 440
 None
None
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
735  A 469 (-4.0A)
 0.98A 5y2tB-2p54A:
34.2		 5y2tB-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 247
ILE A 272
CYH A 276
GLN A 277
ILE A 317
LEU A 321
HIS A 440
 None
735  A 469 ( 4.2A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.8A)
735  A 469 ( 4.3A)
735  A 469 (-4.0A)
 0.75A 5y2tB-2p54A:
34.2		 5y2tB-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9b POSSIBLE PROLIDASE

(Bifidobacterium
longum) 		PF01979
(Amidohydro_1) 		5 ILE A  21
ILE A  55
TYR A  61
ILE A  44
HIS A  18
 None
 1.22A 5y2tB-2p9bA:
undetectable		 5y2tB-2p9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE
BETA-ASPARTATE
METHYLTRANSFERASE

(Plasmodium
falciparum) 		PF01135
(PCMT) 		5 LEU A 160
ILE A  85
ILE A 193
LEU A 175
ILE A 178
 None
 1.18A 5y2tB-2pbfA:
undetectable		 5y2tB-2pbfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 LEU A 519
GLN A 348
ILE A 398
LEU A 394
ILE A 358
 None
 1.13A 5y2tB-2po4A:
undetectable		 5y2tB-2po4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q22 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF08854
(DUF1824) 		5 ILE A 125
CYH A 117
GLN A 118
TYR A  77
LEU A  75
 None
 1.21A 5y2tB-2q22A:
undetectable		 5y2tB-2q22A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlv CARBON CATABOLITE
DEREPRESSING PROTEIN
KINASE

(Saccharomyces
cerevisiae) 		PF16579
(AdenylateSensor) 		5 PHE A 586
GLN A 571
ILE A 522
TYR A 523
LEU A 526
 None
 1.05A 5y2tB-2qlvA:
undetectable		 5y2tB-2qlvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS

(Fasciola
hepatica) 		PF14497
(GST_C_3) 		5 LEU A  78
ILE A  20
GLN A  35
ILE A  44
LEU A  48
 None
 0.96A 5y2tB-2wduA:
undetectable		 5y2tB-2wduA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 PHE A 119
ARG A 117
ILE A  77
LEU A 148
ILE A  28
 None
 1.23A 5y2tB-2xkaA:
undetectable		 5y2tB-2xkaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		5 LEU A   3
ILE A 283
LEU A  40
ILE A  10
HIS A  95
 None
 1.20A 5y2tB-2yh2A:
undetectable		 5y2tB-2yh2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymb MIT
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF16565
(MIT_C) 		5 LEU A 141
PHE A 199
ILE A 151
ILE A 192
ILE A 197
 None
 1.17A 5y2tB-2ymbA:
undetectable		 5y2tB-2ymbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		5 LEU A 524
PHE A 467
ILE A 572
ILE A 346
LEU A 332
 None
 1.21A 5y2tB-2zuyA:
undetectable		 5y2tB-2zuyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 LEU A 255
ARG A 280
ILE A 281
CYH A 285
GLN A 286
ILE A 326
TYR A 327
LEU A 330
ILE A 341
MET A 348
HIS A 449
 None
None
MC5  A   1 ( 4.8A)
MC5  A   1 (-3.6A)
None
MC5  A   1 ( 4.9A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.9A)
 0.61A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
ILE A 281
GLN A 283
ILE A 341
MET A 348
 None
MC5  A   1 ( 4.8A)
None
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
 1.08A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8g PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Shigella
flexneri) 		PF05068
(MtlR) 		5 LEU B  13
ILE B  29
GLN B  36
ILE B  74
LEU B  71
 None
 1.19A 5y2tB-3c8gB:
undetectable		 5y2tB-3c8gB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ccf CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		5 LEU A 235
ILE A 144
ILE A 208
MET A 204
HIS A 109
 None
None
None
None
BEZ  A 261 (-3.7A)
 1.21A 5y2tB-3ccfA:
undetectable		 5y2tB-3ccfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 255
CYH A 285
GLN A 286
ILE A 326
LEU A 330
HIS A 449
 None
L41  A 501 (-3.5A)
None
None
L41  A 501 (-4.9A)
L41  A 501 (-3.9A)
 0.75A 5y2tB-3d5fA:
34.3		 5y2tB-3d5fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		7 ILE D 281
ILE D 326
TYR D 327
LEU D 330
ILE D 341
MET D 348
HIS D 449
 PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
 0.76A 5y2tB-3dzuD:
34.2		 5y2tB-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 LEU D 255
ARG D 280
ILE D 281
GLN D 286
ILE D 326
LEU D 330
ILE D 341
MET D 348
 None
None
PLB  D 701 (-4.6A)
None
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
 0.67A 5y2tB-3dzuD:
34.2		 5y2tB-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 LEU D 255
ARG D 280
ILE D 281
ILE D 326
LEU D 330
ILE D 341
MET D 348
HIS D 449
 None
None
PLB  D 701 (-4.6A)
PLB  D 701 ( 4.5A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
 0.76A 5y2tB-3dzuD:
34.2		 5y2tB-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 561
ILE A 468
LEU A 335
ILE A 481
HIS A 347
 None
 1.21A 5y2tB-3e9yA:
undetectable		 5y2tB-3e9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egl DEGV FAMILY PROTEIN

(Corynebacterium
glutamicum) 		PF02645
(DegV) 		5 LEU A 163
ILE A 152
ILE A  68
LEU A  99
MET A 169
 None
None
None
PLM  A 275 ( 4.6A)
None
 1.02A 5y2tB-3eglA:
undetectable		 5y2tB-3eglA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhl PUTATIVE AGMATINASE

(Clostridioides
difficile) 		PF00491
(Arginase) 		5 LEU A 216
ILE A 214
CYH A 257
LEU A  23
ILE A 107
 None
 1.07A 5y2tB-3lhlA:
undetectable		 5y2tB-3lhlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A 665
CYH A 762
ILE A 789
ILE A 854
HIS A 782
 None
 0.98A 5y2tB-3lltA:
undetectable		 5y2tB-3lltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lws AROMATIC AMINO ACID
BETA-ELIMINATING
LYASE/THREONINE
ALDOLASE

(Exiguobacterium
sibiricum) 		PF01212
(Beta_elim_lyase) 		5 LEU A 132
ARG A 167
ILE A 129
ILE A 192
LEU A 142
 None
 1.18A 5y2tB-3lwsA:
undetectable		 5y2tB-3lwsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 LEU A 300
PHE A 177
ILE A 203
ILE A 146
HIS A 320
 None
 1.13A 5y2tB-3sopA:
undetectable		 5y2tB-3sopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		5 LEU A 300
PHE A 177
ILE A 203
ILE A 146
TYR A 150
 None
 1.20A 5y2tB-3sopA:
undetectable		 5y2tB-3sopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atg TAF6

(Antonospora
locustae) 		PF07571
(TAF6_C) 		5 LEU A 244
ILE A 240
ILE A 175
TYR A 171
ILE A 205
 None
 1.06A 5y2tB-4atgA:
undetectable		 5y2tB-4atgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		5 LEU A 261
CYH A 104
GLN A 103
ILE A  83
ILE A  56
 None
 1.08A 5y2tB-4aurA:
undetectable		 5y2tB-4aurA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF04054
(Not1) 		6 PHE A2030
ILE A1988
GLN A1983
ILE A1978
ILE A2026
MET A2009
 None
 1.30A 5y2tB-4by6A:
undetectable		 5y2tB-4by6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 PHE A 347
ILE A 228
CYH A 307
GLN A 308
ILE A 343
 None
None
None
0H7  A 502 (-3.1A)
None
 1.11A 5y2tB-4da5A:
undetectable		 5y2tB-4da5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5u PROBABLE HYDROLASE
NIT2

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		5 LEU A 283
ILE A 188
ILE A 168
TYR A 125
LEU A 112
 None
None
CAF  A 169 ( 3.9A)
None
None
 1.22A 5y2tB-4h5uA:
undetectable		 5y2tB-4h5uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		5 LEU A  48
ILE A 275
ILE A 330
LEU A 331
ILE A 285
 None
 0.98A 5y2tB-4il5A:
undetectable		 5y2tB-4il5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3b M1 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 PHE A 736
ILE A 691
ILE A 729
LEU A 746
ILE A 742
 None
 1.15A 5y2tB-4j3bA:
undetectable		 5y2tB-4j3bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo0 CMLA

(Streptomyces
venezuelae) 		PF12706
(Lactamase_B_2) 		5 LEU A 301
ILE A 303
ILE A 439
TYR A 440
HIS A 378
 None
 1.14A 5y2tB-4jo0A:
undetectable		 5y2tB-4jo0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mki ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA2

(Caldanaerobacter
subterraneus) 		no annotation 5 LEU B 243
GLN B  90
ILE B 182
LEU B 183
ILE B 207
 None
None
LMT  B 302 ( 4.0A)
None
None
 1.19A 5y2tB-4mkiB:
undetectable		 5y2tB-4mkiB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 ILE A1241
CYH A1285
GLN A1284
ILE A1373
LEU A1276
 None
HG  A2205 (-3.5A)
None
None
None
 1.19A 5y2tB-4o9xA:
undetectable		 5y2tB-4o9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol0 TRANSPORTIN-3

(Homo sapiens) 		PF08389
(Xpo1) 		5 LEU B  91
ILE B 112
GLN B 118
ILE B 169
LEU B 173
 None
 1.23A 5y2tB-4ol0B:
undetectable		 5y2tB-4ol0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on1 PUTATIVE
METALLOPROTEASE II

(Bacteroides
fragilis) 		PF00413
(Peptidase_M10)
PF16376
(fragilysinNterm) 		5 LEU A 304
ILE A 302
ILE A 257
LEU A 248
ILE A 241
 None
 1.23A 5y2tB-4on1A:
undetectable		 5y2tB-4on1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbv NT-3 GROWTH FACTOR
RECEPTOR

(Gallus gallus) 		PF00047
(ig)
PF13855
(LRR_8)
PF16920
(TPKR_C2) 		5 LEU A 142
ILE A 118
TYR A 102
LEU A 105
ILE A 132
 None
 1.15A 5y2tB-4pbvA:
undetectable		 5y2tB-4pbvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzv 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE/DI
HYDROPTEROATE
SYNTHASE

(Francisella
tularensis) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 LEU A 231
ILE A 210
ILE A  15
TYR A 247
ILE A 272
 None
 1.17A 5y2tB-4pzvA:
undetectable		 5y2tB-4pzvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5q GLUTATHIONE
S-TRANSFERASE

(Dermatophagoides
pteronyssinus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A  54
ILE A  65
GLN A   3
TYR A  85
LEU A  81
 None
 1.21A 5y2tB-4q5qA:
undetectable		 5y2tB-4q5qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2p KETOSYNTHASE

(Myxococcus
fulvus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PHE A 333
TYR A 273
LEU A 274
ILE A 262
MET A 298
 None
 1.13A 5y2tB-4v2pA:
undetectable		 5y2tB-4v2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x68 BETA-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00144
(Beta-lactamase) 		5 LEU A  54
GLN A 311
ILE A 305
TYR A 301
LEU A 339
 None
 1.21A 5y2tB-4x68A:
undetectable		 5y2tB-4x68A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yuf CORB

(Corallococcus
coralloides) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PHE A 333
TYR A 273
LEU A 274
ILE A 262
MET A 298
 None
 1.14A 5y2tB-4yufA:
undetectable		 5y2tB-4yufA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx8 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 LEU A 187
ILE A 201
GLN A 218
ILE A  97
LEU A  94
 None
 1.02A 5y2tB-4yx8A:
undetectable		 5y2tB-4yx8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9b POLYHEDRIN

(Cypovirus 1) 		PF05865
(Cypo_polyhedrin) 		5 LEU A 168
ILE A 109
ILE A 225
TYR A 224
LEU A 220
 None
 1.04A 5y2tB-5a9bA:
undetectable		 5y2tB-5a9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a9p POLYHEDRIN

(Operophtera
brumata
cypovirus 18) 		PF05865
(Cypo_polyhedrin) 		5 LEU A 168
ILE A 109
ILE A 225
TYR A 224
LEU A 220
 None
 0.92A 5y2tB-5a9pA:
undetectable		 5y2tB-5a9pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bra PUTATIVE PERIPLASMIC
BINDING PROTEIN WITH
SUBSTRATE RIBOSE

(Ochrobactrum
anthropi) 		PF13407
(Peripla_BP_4) 		5 PHE A  67
ILE A 128
ILE A  91
LEU A  95
ILE A  45
 None
 1.05A 5y2tB-5braA:
undetectable		 5y2tB-5braA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		5 LEU A  85
ILE A  81
GLN A 294
LEU A  50
ILE A 258
 None
 1.23A 5y2tB-5c6uA:
undetectable		 5y2tB-5c6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejh NAD KINASE 1

(Listeria
monocytogenes) 		PF01513
(NAD_kinase) 		5 LEU A  16
ILE A  67
ILE A  62
ILE A   5
MET A  20
 None
 1.12A 5y2tB-5ejhA:
undetectable		 5y2tB-5ejhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyg INOSITOL
MONOPHOSPHATASE

(Staphylococcus
aureus) 		PF00459
(Inositol_P) 		5 LEU A 255
PHE A 159
ILE A 241
GLN A 213
ILE A 157
 None
 1.09A 5y2tB-5eygA:
undetectable		 5y2tB-5eygA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		5 LEU A 110
PHE A 118
ILE A 171
LEU A 172
ILE A 179
 None
 1.17A 5y2tB-5fg3A:
undetectable		 5y2tB-5fg3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmu TRAF3-INTERACTING
PROTEIN 1

(Mus musculus) 		PF10243
(MIP-T3) 		5 GLN A 109
ILE A  38
TYR A  34
LEU A  35
ILE A  77
 None
 1.17A 5y2tB-5fmuA:
undetectable		 5y2tB-5fmuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gja 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
OXIDASE 2

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 LEU A  12
ILE A  27
CYH A  31
LEU A 224
ILE A 218
 None
 1.23A 5y2tB-5gjaA:
undetectable		 5y2tB-5gjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5
COMPLEMENT C5

(Homo sapiens;
Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF01835
(A2M_N)
PF07703
(A2M_N_2) 		5 LEU B 575
ILE A 799
ILE B 182
TYR B 146
HIS B 129
 None
 1.17A 5y2tB-5hccB:
undetectable		 5y2tB-5hccB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis) 		PF13462
(Thioredoxin_4) 		5 LEU A 187
ILE A 201
GLN A 218
ILE A  97
LEU A  94
 None
 0.99A 5y2tB-5id4A:
undetectable		 5y2tB-5id4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LEU A 335
ILE A 337
CYH A 348
ILE A 260
LEU A 263
 None
 1.13A 5y2tB-5jouA:
undetectable		 5y2tB-5jouA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 LEU A 203
ARG A 125
ILE A 172
TYR A 245
ILE A 184
 LEU  A 203 ( 0.5A)
ARG  A 125 ( 0.6A)
ILE  A 172 ( 0.7A)
TYR  A 245 ( 1.3A)
ILE  A 184 ( 0.4A)
 1.21A 5y2tB-5l5nA:
undetectable		 5y2tB-5l5nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lzl DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pyrobaculum
calidifontis) 		PF00490
(ALAD) 		5 LEU A 321
PHE A 121
GLN A 180
LEU A 247
ILE A 253
 None
None
ZN  A 402 ( 4.9A)
None
None
 1.03A 5y2tB-5lzlA:
undetectable		 5y2tB-5lzlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m2n ELONGATOR COMPLEX
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 PHE A 739
GLN A 744
TYR A 783
LEU A 771
ILE A 720
 None
 0.78A 5y2tB-5m2nA:
undetectable		 5y2tB-5m2nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 LEU A 170
GLN A  90
TYR A  77
LEU A  78
ILE A 133
 None
NH3  A 504 ( 4.4A)
None
None
None
 1.16A 5y2tB-5msyA:
undetectable		 5y2tB-5msyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwl INOSITOL-PENTAKISPHO
SPHATE 2-KINASE

(Mus musculus) 		PF06090
(Ins_P5_2-kin) 		5 LEU A 185
ILE A 137
ILE A 132
LEU A 133
ILE A 265
 None
 1.20A 5y2tB-5mwlA:
undetectable		 5y2tB-5mwlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ARG A 387
ILE A 388
ILE A 420
TYR A 405
ILE A 350
 None
 1.00A 5y2tB-5olpA:
undetectable		 5y2tB-5olpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olp PECTATE LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 ARG A 387
ILE A 420
TYR A 405
LEU A 364
ILE A 350
 None
 1.08A 5y2tB-5olpA:
undetectable		 5y2tB-5olpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 PHE A 102
ILE A  66
GLN A 110
LEU A 260
ILE A  70
 None
 1.22A 5y2tB-5tg8A:
undetectable		 5y2tB-5tg8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2i NUCLEOSIDE
DIPHOSPHATE KINASE

(Naegleria
fowleri) 		PF00334
(NDK) 		5 LEU A  10
ILE A  24
GLN A  29
ILE A 149
MET A  75
 None
 0.96A 5y2tB-5u2iA:
undetectable		 5y2tB-5u2iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A 396
GLN A 310
ILE A 245
LEU A 382
ILE A 390
 None
 1.06A 5y2tB-5u4hA:
undetectable		 5y2tB-5u4hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u63 THIOREDOXIN
REDUCTASE

(Haemophilus
influenzae) 		PF07992
(Pyr_redox_2) 		5 LEU A 239
ILE A 175
ILE A 188
TYR A 192
LEU A 191
 None
 1.09A 5y2tB-5u63A:
undetectable		 5y2tB-5u63A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Acinetobacter
baumannii) 		PF01116
(F_bP_aldolase) 		5 ARG A 343
ILE A 335
ILE A  70
ILE A 332
HIS A   0
 None
 1.11A 5y2tB-5u7sA:
undetectable		 5y2tB-5u7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 CYH D 441
GLN D 440
ILE D 491
ILE D 522
MET D 541
 None
 1.17A 5y2tB-5uheD:
undetectable		 5y2tB-5uheD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhb POLYHEDRIN

(Cypovirus 1) 		no annotation 5 LEU A 168
ILE A 109
ILE A 225
TYR A 224
LEU A 220
 None
 0.97A 5y2tB-5yhbA:
undetectable		 5y2tB-5yhbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 115
PHE A 127
ILE A 158
ILE A 303
ILE A 241
 None
 1.16A 5y2tB-5yk2A:
undetectable		 5y2tB-5yk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zzk MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		no annotation 5 GLN A 136
ILE A 172
LEU A 173
ILE A 180
HIS A 107
 None
 1.08A 5y2tB-5zzkA:
undetectable		 5y2tB-5zzkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 5 LEU A 405
PHE A 322
ILE A 426
ILE A 215
LEU A 307
 None
 1.21A 5y2tB-6bpcA:
undetectable		 5y2tB-6bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 LEU A  74
ILE A 176
ILE A 200
MET A 204
HIS A 179
 None
 1.22A 5y2tB-6c54A:
undetectable		 5y2tB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 5 LEU A  74
PHE A  60
ILE A 176
ILE A 200
MET A 204
 None
 1.21A 5y2tB-6c54A:
undetectable		 5y2tB-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D
MBH SUBUNIT

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 ARG I 114
ILE I 110
ILE H 263
LEU H 223
ILE H 286
 None
 1.00A 5y2tB-6cfwI:
undetectable		 5y2tB-6cfwI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 PHE A  99
GLN A 104
ILE A 154
TYR A 142
ILE A  78
 None
 0.83A 5y2tB-6en4A:
undetectable		 5y2tB-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 LEU A 447
ILE A 220
GLN A 193
ILE A 154
ILE A 248
 None
 1.19A 5y2tB-6fsaA:
undetectable		 5y2tB-6fsaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf2 ISOAMYLASE

(Pseudomonas
amyloderamosa) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 HIS A 185
PHE A 189
MET A 278
LEU A 214
 None
 1.08A 5y2tB-1bf2A:
0.0		 5y2tB-1bf2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLU A 544
PHE A 206
HIS A 127
LEU A 176
 None
 1.11A 5y2tB-1bhgA:
0.0		 5y2tB-1bhgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 PHE A 164
SER A  38
HIS A  30
PHE A 167
 None
 1.04A 5y2tB-1brtA:
0.0		 5y2tB-1brtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpg GLUTAMIC ACID
SPECIFIC PROTEASE

(Streptomyces
griseus) 		no annotation 4 HIS A 228
PHE A 200
SER A 159
LEU A 120
 None
 1.07A 5y2tB-1hpgA:
undetectable		 5y2tB-1hpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4w MITOCHONDRIAL
REPLICATION PROTEIN
MTF1

(Saccharomyces
cerevisiae) 		PF00398
(RrnaAD) 		4 GLU A  46
PHE A 132
PHE A 118
LEU A 160
 None
 1.05A 5y2tB-1i4wA:
0.0		 5y2tB-1i4wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 HIS A  11
PHE A 218
PHE A  34
MET A  35
 None
 1.11A 5y2tB-1k1xA:
0.0		 5y2tB-1k1xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvm CATALYTIC DOMAIN OF
THE NUCLEAR
INCLUSION PROTEIN A
(NIA)

(Tobacco etch
virus) 		PF00863
(Peptidase_C4) 		4 GLU A  24
PHE A  64
PHE A  91
MET A  87
 None
 1.09A 5y2tB-1lvmA:
undetectable		 5y2tB-1lvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 GLU A 243
PHE A 153
PHE A 120
LEU A  87
 None
 1.05A 5y2tB-1mnnA:
undetectable		 5y2tB-1mnnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLU A 577
SER A 445
HIS A 440
LEU A 383
 None
 0.94A 5y2tB-1n7rA:
0.6		 5y2tB-1n7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbb CYTOCHROME C'

(Rhodobacter
capsulatus) 		PF01322
(Cytochrom_C_2) 		4 GLU A  69
SER A  20
MET A  88
LEU A 111
 HEM  A 130 (-2.9A)
None
HEM  A 130 ( 4.2A)
None
 0.97A 5y2tB-1nbbA:
undetectable		 5y2tB-1nbbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		4 HIS A 206
PHE A 294
PHE A 263
LEU A 258
 None
 1.06A 5y2tB-1phzA:
0.0		 5y2tB-1phzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgt PROTEIN (HBV CAPSID
PROTEIN)

(Hepatitis B
virus) 		no annotation 4 PHE C  24
SER C 106
PHE C  23
LEU C  16
 None
 1.03A 5y2tB-1qgtC:
undetectable		 5y2tB-1qgtC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 435
PHE A 430
MET A 425
LEU A 244
 None
 1.03A 5y2tB-1ulzA:
0.0		 5y2tB-1ulzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 GLU A 271
PHE A 375
PHE A  43
LEU A  57
 None
 1.04A 5y2tB-1ur4A:
undetectable		 5y2tB-1ur4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		4 GLU A  29
PHE A 198
PHE A 447
LEU A 436
 None
 0.91A 5y2tB-1v4gA:
undetectable		 5y2tB-1v4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		4 GLU A  21
PHE A 118
MET A 119
LEU A 130
 None
 1.01A 5y2tB-1vffA:
undetectable		 5y2tB-1vffA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wid DNA-BINDING PROTEIN
RAV1

(Arabidopsis
thaliana) 		PF02362
(B3) 		4 HIS A 213
PHE A 274
PHE A 230
LEU A 203
 None
 1.09A 5y2tB-1widA:
undetectable		 5y2tB-1widA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 HIS B 159
PHE B  27
PHE B 106
LEU B  44
 None
 1.02A 5y2tB-1zunB:
undetectable		 5y2tB-1zunB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 GLU A 455
PHE A 474
SER A 428
PHE A 520
 None
 1.02A 5y2tB-2c9kA:
undetectable		 5y2tB-2c9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 HIS A 368
PHE A 358
SER A 409
LEU A 344
 None
 1.10A 5y2tB-2gmhA:
undetectable		 5y2tB-2gmhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		4 GLU A 113
PHE A 183
PHE A 177
MET A 173
 None
 1.10A 5y2tB-2ocaA:
undetectable		 5y2tB-2ocaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		4 GLU A 180
HIS A  81
PHE A 175
LEU A  99
 None
ZN  A 500 ( 3.3A)
None
GUN  A 600 (-4.2A)
 0.97A 5y2tB-2oodA:
undetectable		 5y2tB-2oodA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooj HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF11528
(DUF3224) 		4 HIS A 102
PHE A 132
MET A   3
LEU A  73
 None
 1.07A 5y2tB-2oojA:
undetectable		 5y2tB-2oojA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz8 MLL7089 PROTEIN

(Mesorhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 HIS A  67
PHE A  65
SER A  72
LEU A  36
 None
 1.04A 5y2tB-2oz8A:
undetectable		 5y2tB-2oz8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 GLU A 278
PHE A 154
SER A 219
MET A  36
 None
 1.08A 5y2tB-2q6zA:
undetectable		 5y2tB-2q6zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		4 GLU A 280
HIS A 218
PHE A 136
LEU A 150
 ZN  A 400 (-2.5A)
XLS  A 401 (-4.3A)
None
None
 0.97A 5y2tB-2qw5A:
undetectable		 5y2tB-2qw5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vp3 VP39

(Vaccinia virus) 		PF01358
(PARP_regulatory) 		4 GLU A  15
SER A  51
HIS A  81
LEU A 286
 None
 0.93A 5y2tB-2vp3A:
undetectable		 5y2tB-2vp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 365
PHE A 125
PHE A  88
LEU A 272
 None
 0.89A 5y2tB-2xf2A:
undetectable		 5y2tB-2xf2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4r CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Thermotoga
maritima) 		PF00308
(Bac_DnaA) 		4 PHE A 134
SER A 168
PHE A 252
LEU A 241
 None
 1.08A 5y2tB-2z4rA:
undetectable		 5y2tB-2z4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu0 PROTEIN SUFD

(Escherichia
coli) 		PF01458
(UPF0051) 		4 GLU A 187
HIS A 227
PHE A 126
LEU A  41
 None
 0.97A 5y2tB-2zu0A:
undetectable		 5y2tB-2zu0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8r PUTATIVE
UNCHARACTERIZED
PROTEIN

(Oryza sativa) 		PF08414
(NADPH_Ox)
PF13499
(EF-hand_7) 		4 GLU A 256
PHE A 199
PHE A 182
LEU A 213
 None
 0.90A 5y2tB-3a8rA:
undetectable		 5y2tB-3a8rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 259
PHE A 282
PHE A 363
MET A 364
LEU A 453
 None
MC5  A   1 (-4.4A)
None
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
 1.00A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 259
PHE A 282
SER A 289
HIS A 323
MET A 364
 None
MC5  A   1 (-4.4A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
MC5  A   1 (-3.7A)
 0.79A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLU A 259
PHE A 282
SER A 289
MET A 364
LEU A 453
 None
MC5  A   1 (-4.4A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
 0.89A 5y2tB-3b0qA:
36.8		 5y2tB-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdv UNCHARACTERIZED
PROTEIN DUF1234

(Pectobacterium
atrosepticum) 		PF06821
(Ser_hydrolase) 		4 GLU A 166
HIS A  80
PHE A  82
LEU A  57
 None
 1.07A 5y2tB-3bdvA:
undetectable		 5y2tB-3bdvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 GLU A  20
PHE A  74
SER A 355
LEU A 381
 None
 1.08A 5y2tB-3d45A:
undetectable		 5y2tB-3d45A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0c TRANSCRIPTIONAL
REGULATOR

(Cytophaga
hutchinsonii) 		PF00440
(TetR_N) 		4 HIS A 101
PHE A  99
SER A 106
LEU A 172
 None
 1.02A 5y2tB-3f0cA:
undetectable		 5y2tB-3f0cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2v PREC/CORE PROTEIN

(Hepatitis B
virus) 		no annotation 4 PHE C  24
SER C 106
PHE C  23
LEU C  16
 None
 0.98A 5y2tB-3j2vC:
undetectable		 5y2tB-3j2vC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		4 HIS A 319
PHE A 324
SER A 311
LEU A 372
 ACT  A 382 (-4.5A)
None
None
None
 1.09A 5y2tB-3ke3A:
undetectable		 5y2tB-3ke3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3keh GLUCOCEREBROSIDASE

(Homo sapiens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 GLU A 340
HIS A 223
PHE A 216
LEU A 149
 None
 1.10A 5y2tB-3kehA:
undetectable		 5y2tB-3kehA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		4 GLU A 109
HIS A 382
SER A 375
LEU A 170
 None
 0.80A 5y2tB-3lkbA:
undetectable		 5y2tB-3lkbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 GLU A  26
SER A  97
PHE A 404
LEU A 256
 None
 0.92A 5y2tB-3lq1A:
undetectable		 5y2tB-3lq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1a PUTATIVE
DEHYDROGENASE

(Streptomyces
avermitilis) 		PF00106
(adh_short) 		4 HIS A 258
PHE A 145
SER A 138
LEU A 213
 None
 1.07A 5y2tB-3m1aA:
undetectable		 5y2tB-3m1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 GLU B 509
HIS A 207
PHE B 515
MET B 541
 None
 0.97A 5y2tB-3pcoB:
undetectable		 5y2tB-3pcoB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2h A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 1

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 153
PHE A 155
SER A 132
LEU A 211
 QHF  A   1 ( 3.0A)
None
None
None
 1.06A 5y2tB-3q2hA:
undetectable		 5y2tB-3q2hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 GLU A 342
SER A 240
PHE A 315
LEU A 265
 None
 1.07A 5y2tB-3tqiA:
undetectable		 5y2tB-3tqiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		4 GLU A 198
SER A 102
MET A  52
LEU A 120
 None
 1.06A 5y2tB-3tr1A:
undetectable		 5y2tB-3tr1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v44 TOLL-LIKE RECEPTOR
5B AND VARIABLE
LYMPHOCYTE RECEPTOR
B.61 CHIMERIC
PROTEIN

(Eptatretus
burgeri;
Danio rerio) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 PHE A 250
SER A 266
PHE A 286
LEU A 261
 None
 1.00A 5y2tB-3v44A:
undetectable		 5y2tB-3v44A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 304
HIS A 279
PHE A 305
LEU A 341
 None
 1.08A 5y2tB-3v7nA:
undetectable		 5y2tB-3v7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 PHE A 224
HIS A 179
PHE A 228
LEU A  82
 None
UNL  A 436 ( 3.9A)
BEZ  A 430 ( 4.6A)
None
 0.98A 5y2tB-3v7pA:
undetectable		 5y2tB-3v7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8u TRANSFERRIN
BINDING-PROTEIN B

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 GLU A  64
PHE A 166
SER A 344
LEU A 104
 None
 1.10A 5y2tB-3v8uA:
undetectable		 5y2tB-3v8uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		4 HIS A 335
PHE A 311
PHE A 303
LEU A 267
 None
 1.08A 5y2tB-3vcyA:
undetectable		 5y2tB-3vcyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLU A 636
HIS A 916
SER A 921
LEU A 847
 RAM  A1202 (-3.1A)
RAM  A1202 (-4.0A)
None
None
 1.07A 5y2tB-3w5nA:
undetectable		 5y2tB-3w5nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 PHE A 264
PHE A 282
MET A 385
LEU A 293
 None
 1.04A 5y2tB-4aioA:
undetectable		 5y2tB-4aioA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 403
PHE A 163
PHE A 126
LEU A 310
 None
 0.81A 5y2tB-4aj9A:
undetectable		 5y2tB-4aj9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni) 		no annotation 4 GLU A  52
HIS A 140
PHE A 179
PHE A 104
 None
 1.02A 5y2tB-4bg2A:
undetectable		 5y2tB-4bg2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3s IMINE REDUCTASE

(Nocardiopsis
halophila) 		PF03446
(NAD_binding_2) 		4 GLU A 148
PHE A 139
PHE A 137
LEU A 177
 None
 1.08A 5y2tB-4d3sA:
undetectable		 5y2tB-4d3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 GLU A1283
PHE A1045
SER A1129
LEU A1084
 None
 0.93A 5y2tB-4fbqA:
undetectable		 5y2tB-4fbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 4 GLU B 283
PHE B  45
SER B 129
LEU B  84
 None
 1.00A 5y2tB-4fcxB:
undetectable		 5y2tB-4fcxB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iq4 NON-HAEM
BROMOPEROXIDASE
BPO-A2, MATRIX
PROTEIN 1

(Kitasatospora
aureofaciens;
Influenza A
virus) 		PF00561
(Abhydrolase_1)
PF00598
(Flu_M1) 		4 PHE A 164
SER A  38
HIS A  30
PHE A 167
 None
 1.08A 5y2tB-4iq4A:
undetectable		 5y2tB-4iq4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		4 PHE A  51
SER A 174
HIS A 137
PHE A  52
 INS  A 401 (-3.5A)
INS  A 401 (-2.5A)
None
None
 0.97A 5y2tB-4irxA:
undetectable		 5y2tB-4irxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nov XYLOSIDASE/ARABINOFU
RANOSIDASE XSA43E

(Butyrivibrio
proteoclasticus) 		PF04616
(Glyco_hydro_43) 		4 GLU A 227
HIS A 273
PHE A 271
HIS A  12
 None
 1.08A 5y2tB-4novA:
undetectable		 5y2tB-4novA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E

(Aeropyrum
pernix) 		PF01040
(UbiA) 		4 HIS A 126
PHE A 174
HIS A   8
PHE A 258
 None
None
GST  A 301 ( 4.9A)
None
 0.95A 5y2tB-4od5A:
undetectable		 5y2tB-4od5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 SER A  44
HIS A 735
PHE A 801
LEU A 721
 None
 1.07A 5y2tB-4ogcA:
undetectable		 5y2tB-4ogcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1t ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding) 		4 GLU A1545
HIS A1345
PHE A1343
SER A1350
 None
 0.96A 5y2tB-4p1tA:
undetectable		 5y2tB-4p1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 GLU A  88
PHE A 302
SER A 219
PHE A 303
 None
 1.10A 5y2tB-4p4sA:
undetectable		 5y2tB-4p4sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 GLU B  88
PHE B 302
SER B 219
PHE B 303
 None
 1.09A 5y2tB-4p4sB:
undetectable		 5y2tB-4p4sB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r42 ALR3090 PROTEIN

(Nostoc sp. PCC
7120) 		PF05067
(Mn_catalase) 		4 GLU A   7
HIS A   4
PHE A  66
LEU A  40
 None
 0.93A 5y2tB-4r42A:
undetectable		 5y2tB-4r42A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk7 A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 4

(Homo sapiens) 		PF01421
(Reprolysin) 		4 HIS A 365
PHE A 367
SER A 344
LEU A 424
 ZN  A 501 ( 3.3A)
None
None
None
 1.11A 5y2tB-4wk7A:
undetectable		 5y2tB-4wk7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wpe CYTOKINESIS PROTEIN
2

(Saccharomyces
cerevisiae) 		PF00611
(FCH) 		4 PHE A  38
SER A 235
PHE A  37
LEU A 228
 None
 1.08A 5y2tB-4wpeA:
undetectable		 5y2tB-4wpeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsh UROPORPHYRINOGEN
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF01208
(URO-D) 		4 GLU A 266
PHE A 145
SER A 210
MET A  26
 None
None
SO4  A 407 ( 4.7A)
SO4  A 407 ( 4.6A)
 1.01A 5y2tB-4wshA:
undetectable		 5y2tB-4wshA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		4 PHE A  75
SER A  15
HIS A  89
LEU A  60
 None
 0.89A 5y2tB-4yisA:
undetectable		 5y2tB-4yisA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN

(Homo sapiens) 		PF00782
(DSPc)
PF10409
(PTEN_C2) 		4 GLU A 284
PHE A 279
PHE A 278
LEU A  98
 None
 1.05A 5y2tB-5bugA:
undetectable		 5y2tB-5bugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a POLYMERASE ACIDIC
PROTEIN
RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus;
Influenza C
virus) 		PF00603
(Flu_PA)
PF00602
(Flu_PB1) 		4 PHE B  61
SER A 198
PHE B 403
LEU B 224
 None
 0.85A 5y2tB-5d9aB:
undetectable		 5y2tB-5d9aB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		4 HIS A  20
PHE A  69
PHE A  42
LEU A 348
 HIS  A  20 ( 1.0A)
PHE  A  69 ( 1.3A)
PHE  A  42 ( 1.3A)
LEU  A 348 ( 0.6A)
 1.11A 5y2tB-5ec3A:
undetectable		 5y2tB-5ec3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 HIS A2024
PHE A2023
PHE A2047
MET A2051
 None
 1.11A 5y2tB-5fu7A:
undetectable		 5y2tB-5fu7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		4 HIS A2282
PHE A2284
HIS A2114
LEU A2220
 None
 1.03A 5y2tB-5fu7A:
undetectable		 5y2tB-5fu7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 PHE E 172
SER E  64
MET E 177
LEU E 116
 None
 1.09A 5y2tB-5g06E:
undetectable		 5y2tB-5g06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 389
PHE A 375
MET A 374
LEU A 412
 None
 1.06A 5y2tB-5gs0A:
undetectable		 5y2tB-5gs0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 GLU A 515
PHE A 388
SER A 431
LEU A 492
 None
 1.08A 5y2tB-5h5mA:
undetectable		 5y2tB-5h5mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE

(Mus musculus) 		PF03079
(ARD) 		4 GLU A  93
PHE A 135
PHE A  84
LEU A 137
 None
69O  A 202 (-3.1A)
69O  A 202 (-3.6A)
None
 1.11A 5y2tB-5i93A:
undetectable		 5y2tB-5i93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 4 GLU A 258
PHE A 317
SER A 363
LEU A 370
 None
 0.75A 5y2tB-5iwzA:
undetectable		 5y2tB-5iwzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mse GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria) 		no annotation 4 GLU A 176
HIS A 148
MET A 218
LEU A  42
 None
CRO  A  66 ( 3.8A)
None
None
 1.06A 5y2tB-5mseA:
undetectable		 5y2tB-5mseA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ns8 -

(-) 		no annotation 4 GLU A 339
PHE A 243
SER A 192
PHE A 265
 None
 1.07A 5y2tB-5ns8A:
undetectable		 5y2tB-5ns8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLU A2344
HIS A2689
PHE A2682
LEU A2632
 MG  A4803 ( 3.1A)
None
None
None
 1.02A 5y2tB-5nugA:
undetectable		 5y2tB-5nugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 GLU A 321
PHE A 732
PHE A 718
MET A 717
 None
 0.85A 5y2tB-5svcA:
undetectable		 5y2tB-5svcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 HIS A 352
PHE A 433
HIS A 375
PHE A 368
 None
 1.08A 5y2tB-5u70A:
undetectable		 5y2tB-5u70A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 GLU A 395
HIS A 342
SER A 332
HIS A  67
 None
 1.01A 5y2tB-5uamA:
undetectable		 5y2tB-5uamA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v91 FOSFOMYCIN
RESISTANCE PROTEIN

(Klebsiella
pneumoniae) 		PF00903
(Glyoxalase) 		4 HIS A 110
PHE A  21
MET A  28
LEU A  84
 None
 1.07A 5y2tB-5v91A:
undetectable		 5y2tB-5v91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3

(Escherichia
coli) 		PF00903
(Glyoxalase) 		4 HIS A 110
PHE A  21
MET A  28
LEU A  84
 None
 1.09A 5y2tB-5vb0A:
undetectable		 5y2tB-5vb0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 HIS A 338
PHE A 314
PHE A 306
LEU A 270
 None
 1.08A 5y2tB-5wi5A:
undetectable		 5y2tB-5wi5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wt4 CYSTEINE DESULFURASE
ISCS

(Helicobacter
pylori) 		no annotation 4 GLU A 103
HIS A 178
PHE A 202
LEU A  55
 None
 1.08A 5y2tB-5wt4A:
undetectable		 5y2tB-5wt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4r S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 HIS A 298
PHE A 228
PHE A 183
LEU A 187
 None
 1.11A 5y2tB-5x4rA:
undetectable		 5y2tB-5x4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 HIS A 298
PHE A 228
PHE A 183
LEU A 187
 None
 1.11A 5y2tB-5x59A:
undetectable		 5y2tB-5x59A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 PHE A 233
SER A 207
PHE A 258
LEU A 218
 None
 0.95A 5y2tB-5zqeA:
undetectable		 5y2tB-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 4 PHE 2 686
SER 2 545
PHE 2 665
LEU 2 605
 None
 1.05A 5y2tB-5zvs2:
undetectable		 5y2tB-5zvs2:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxa TOLL-LIKE RECEPTOR
5B, VARIABLE
LYMPHOCYTE RECEPTOR
B CHIMERA

(Eptatretus
burgeri;
Danio rerio) 		no annotation 4 PHE A 250
SER A 266
PHE A 286
LEU A 261
 None
 0.99A 5y2tB-6bxaA:
undetectable		 5y2tB-6bxaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 HIS A 722
PHE A 727
SER A 779
LEU A 800
 None
 1.07A 5y2tB-6ez8A:
undetectable		 5y2tB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 HIS A 156
PHE A  79
PHE A 138
MET A 129
 None
 1.00A 5y2tB-6f91A:
undetectable		 5y2tB-6f91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftl RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Skeletonema
marinoi) 		no annotation 4 GLU A 208
HIS A 330
PHE A 203
LEU A 166
 MG  A 500 ( 2.7A)
CAP  A 501 (-3.8A)
None
None
 1.08A 5y2tB-6ftlA:
undetectable		 5y2tB-6ftlA:
undetectable