SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y2T_A_8LXA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akc ASPARTATE
AMINOTRANSFERASE

(Gallus gallus) 		PF00155
(Aminotran_1_2) 		5 LEU A 400
PHE A 360
GLY A  36
TYR A 263
HIS A 258
 None
None
None
None
PPE  A 411 (-4.9A)
 1.26A 5y2tA-1akcA:
undetectable		 5y2tA-1akcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
SMALL SUBUNIT
[NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans;
Desulfovibrio
desulfuricans) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
PF00374
(NiFeSe_Hases) 		5 LEU B  47
GLY A  76
LEU A 102
ILE A  78
MET A  94
 None
FSX  A 269 ( 4.1A)
None
None
None
 1.07A 5y2tA-1e3dB:
0.0		 5y2tA-1e3dB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 LEU A 202
GLY A 158
LEU A  86
ILE A 160
LEU A 438
 None
 0.74A 5y2tA-1ewkA:
undetectable		 5y2tA-1ewkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwc GLUTATHIONE
S-TRANSFERASE TSI-1

(Aegilops
tauschii) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 LEU A  88
PHE A 153
GLY A 154
LEU A 202
LEU A 192
 None
 1.21A 5y2tA-1gwcA:
undetectable		 5y2tA-1gwcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i4e CASPASE-8

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU B2440
PHE B2355
GLY B2402
LEU B2270
LEU B2296
 None
 1.11A 5y2tA-1i4eB:
0.0		 5y2tA-1i4eB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 LEU A 242
GLY A 200
LEU A  51
MET A 272
LEU A 191
 None
 1.26A 5y2tA-1kijA:
undetectable		 5y2tA-1kijA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpy CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase) 		5 PHE A  67
GLN A  12
MET A 156
HIS A  10
LEU A 100
 None
 1.16A 5y2tA-1mpyA:
0.0		 5y2tA-1mpyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nt2 FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN

(Archaeoglobus
fulgidus) 		PF01269
(Fibrillarin) 		5 LEU A  55
LEU A 195
ILE A  47
MET A 160
LEU A 180
 None
 1.28A 5y2tA-1nt2A:
0.0		 5y2tA-1nt2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqh HYPOTHETICAL PROTEIN
CG14615-PA

(Drosophila
melanogaster) 		PF08445
(FR47) 		5 LEU A 283
PHE A 231
GLY A 233
TYR A 201
ILE A 226
 None
 1.12A 5y2tA-1sqhA:
undetectable		 5y2tA-1sqhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t71 PHOSPHATASE

(Mycoplasma
pneumoniae) 		PF13277
(YmdB) 		5 LEU A  26
PHE A   7
LEU A 191
ILE A 263
LEU A 152
 None
 1.19A 5y2tA-1t71A:
undetectable		 5y2tA-1t71A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		5 LEU A 145
PHE A 160
LEU A  15
ILE A 169
LEU A 236
 None
 1.20A 5y2tA-1td6A:
undetectable		 5y2tA-1td6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLN A 211
TYR A 236
LEU A 237
ILE A 183
MET A 325
 None
 1.14A 5y2tA-1tmoA:
undetectable		 5y2tA-1tmoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		5 LEU C 218
GLY C 200
LEU C 155
ILE C 196
LEU C 169
 None
 1.16A 5y2tA-1u6gC:
undetectable		 5y2tA-1u6gC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		5 LEU A  45
PHE A  31
GLY A  27
ILE A  25
HIS A 318
 None
NH3  A 401 ( 4.3A)
None
None
NH3  A 401 ( 3.9A)
 1.11A 5y2tA-1u7gA:
undetectable		 5y2tA-1u7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B) 		5 LEU A 376
GLY A 389
GLN A 404
LEU A 302
MET A 298
 None
None
CU  A   4 (-3.6A)
None
None
 0.97A 5y2tA-1yewA:
undetectable		 5y2tA-1yewA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		5 LEU B2218
GLY B2200
GLN B2204
ILE B2193
MET B2186
 None
 1.24A 5y2tA-2assB:
undetectable		 5y2tA-2assB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cyb TYROSYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF00579
(tRNA-synt_1b) 		5 GLY A  63
GLN A  60
LEU A 173
ILE A  27
LEU A 102
 None
 1.12A 5y2tA-2cybA:
undetectable		 5y2tA-2cybA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A 383
GLY A 338
LEU A 203
ILE A 242
LEU A 268
 None
 1.23A 5y2tA-2erqA:
undetectable		 5y2tA-2erqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN
ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Escherichia
coli;
Escherichia
coli) 		PF03255
(ACCA)
PF01039
(Carboxyl_trans) 		5 GLY B 205
TYR B 194
LEU B 213
ILE A 181
LEU B 108
 None
 1.22A 5y2tA-2f9yB:
undetectable		 5y2tA-2f9yB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fex CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF01965
(DJ-1_PfpI) 		5 LEU A  83
PHE A  12
GLY A  71
LEU A  20
LEU A  48
 None
 1.04A 5y2tA-2fexA:
undetectable		 5y2tA-2fexA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		5 LEU A 212
PHE A 346
GLY A 344
LEU A 440
ILE A 340
 None
 1.19A 5y2tA-2hb6A:
undetectable		 5y2tA-2hb6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 PHE A 103
GLY A 105
GLN A 107
TYR A 604
LEU A  50
 None
 1.17A 5y2tA-2hpiA:
undetectable		 5y2tA-2hpiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caldanaerobacter
subterraneus) 		PF13407
(Peripla_BP_4) 		6 LEU A 196
PHE A 215
GLY A 217
GLN A 236
ILE A 225
MET A 230
 None
None
None
RIP  A 401 (-3.2A)
None
None
 1.32A 5y2tA-2ioyA:
undetectable		 5y2tA-2ioyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooe CLEAVAGE STIMULATION
FACTOR 77 KDA
SUBUNIT

(Mus musculus) 		PF05843
(Suf) 		5 LEU A  87
PHE A  67
GLY A  65
LEU A 335
LEU A  32
 None
 1.17A 5y2tA-2ooeA:
undetectable		 5y2tA-2ooeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 247
CYH A 276
LEU A 321
MET A 355
HIS A 440
 None
735  A 469 (-2.9A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
 0.84A 5y2tA-2p54A:
36.2		 5y2tA-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 247
PHE A 273
CYH A 276
GLN A 277
LEU A 321
MET A 355
 None
735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
 0.72A 5y2tA-2p54A:
36.2		 5y2tA-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 273
CYH A 276
GLN A 277
LEU A 321
ILE A 339
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-4.4A)
735  A 469 ( 4.3A)
735  A 469 ( 4.1A)
 1.23A 5y2tA-2p54A:
36.2		 5y2tA-2p54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsv SERINE/THREONINE-PRO
TEIN KINASE VRK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 309
LEU A 155
ILE A 323
MET A 251
LEU A 183
 None
 1.17A 5y2tA-2rsvA:
undetectable		 5y2tA-2rsvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxg DIHYDRODIPICOLINATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00701
(DHDPS) 		5 LEU A  87
GLY A  42
LEU A  23
ILE A  59
LEU A 264
 None
 1.20A 5y2tA-2yxgA:
undetectable		 5y2tA-2yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwi ALPHA-/BETA-GALACTOS
IDE
ALPHA-2,3-SIALYLTRAN
SFERASE

(Photobacterium
phosphoreum) 		PF11477
(PM0188) 		5 LEU A 344
GLY A 316
LEU A 292
ILE A 276
MET A 332
 None
C5P  A   1 (-4.3A)
None
C5P  A   1 (-4.0A)
None
 1.20A 5y2tA-2zwiA:
undetectable		 5y2tA-2zwiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 255
CYH A 285
LEU A 330
ILE A 341
MET A 348
LEU A 465
 None
MC5  A   1 (-3.6A)
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
None
 1.23A 5y2tA-3b0qA:
40.2		 5y2tA-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 LEU A 255
PHE A 282
GLY A 284
CYH A 285
GLN A 286
TYR A 327
LEU A 330
ILE A 341
MET A 348
MET A 364
HIS A 449
LEU A 453
 None
MC5  A   1 (-4.4A)
MC5  A   1 ( 4.5A)
MC5  A   1 (-3.6A)
None
None
MC5  A   1 (-4.4A)
MC5  A   1 (-4.5A)
MC5  A   1 ( 4.0A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
 0.60A 5y2tA-3b0qA:
40.2		 5y2tA-3b0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		5 PHE A 445
GLY A 552
GLN A 555
LEU A 599
ILE A 619
 None
 1.21A 5y2tA-3cskA:
undetectable		 5y2tA-3cskA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 255
PHE A 282
CYH A 285
GLN A 286
LEU A 330
 None
L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
None
L41  A 501 (-4.9A)
 0.60A 5y2tA-3d5fA:
35.9		 5y2tA-3d5fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dyt SORTING NEXIN-9

(Homo sapiens) 		PF00787
(PX)
PF10456
(BAR_3_WASP_bdg) 		5 PHE A 503
GLY A 501
CYH A 502
LEU A 298
LEU A 548
 None
 1.27A 5y2tA-3dytA:
undetectable		 5y2tA-3dytA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH D 285
TYR D 327
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 0.98A 5y2tA-3dzuD:
36.6		 5y2tA-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 GLY D 284
CYH D 285
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 1.07A 5y2tA-3dzuD:
36.6		 5y2tA-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 GLY D 284
LEU D 330
ILE D 341
MET D 348
MET D 364
HIS D 449
 PLB  D 701 (-3.3A)
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
None
 0.80A 5y2tA-3dzuD:
36.6		 5y2tA-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		8 LEU D 255
PHE D 282
GLY D 284
GLN D 286
LEU D 330
ILE D 341
MET D 348
MET D 364
 None
None
PLB  D 701 (-3.3A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
PLB  D 701 ( 4.8A)
 0.52A 5y2tA-3dzuD:
36.6		 5y2tA-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 LEU D 255
PHE D 363
LEU D 330
ILE D 341
MET D 348
LEU D 452
 None
None
PLB  D 701 ( 4.1A)
PLB  D 701 (-3.6A)
PLB  D 701 ( 4.7A)
None
 1.45A 5y2tA-3dzuD:
36.6		 5y2tA-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 PHE D 282
GLY D 284
CYH D 285
GLN D 286
LEU D 330
MET D 364
 None
PLB  D 701 (-3.3A)
PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
 0.89A 5y2tA-3dzuD:
36.6		 5y2tA-3dzuD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		5 PHE A 131
LEU A 293
ILE A 216
MET A 220
LEU A 352
 None
 1.18A 5y2tA-3e3pA:
undetectable		 5y2tA-3e3pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8

(Homo sapiens) 		PF12134
(PRP8_domainIV) 		5 LEU A1905
PHE A1818
GLN A1816
LEU A1936
ILE A1967
 None
 1.12A 5y2tA-3e9lA:
undetectable		 5y2tA-3e9lA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 LEU A 194
GLY A  89
TYR A 117
LEU A 120
LEU A  66
 None
 1.24A 5y2tA-3fy4A:
undetectable		 5y2tA-3fy4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 5 GLY B 133
LEU B 164
ILE B 122
HIS B  93
LEU B 293
 None
 1.18A 5y2tA-3h4jB:
undetectable		 5y2tA-3h4jB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		5 LEU A 284
GLY A 324
CYH A 325
GLN A 320
LEU A 308
 None
 1.28A 5y2tA-3ibjA:
undetectable		 5y2tA-3ibjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 164
PHE A 153
GLY A 149
TYR A  65
LEU A  56
 None
 1.10A 5y2tA-3jq1A:
undetectable		 5y2tA-3jq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 166
PHE A 153
GLY A 149
TYR A  65
LEU A  56
 None
 1.17A 5y2tA-3jq1A:
undetectable		 5y2tA-3jq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 LEU A  43
GLY A 277
CYH A 276
LEU A 299
ILE A 273
 None
 1.28A 5y2tA-3n2xA:
undetectable		 5y2tA-3n2xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd0 SLL0855 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00654
(Voltage_CLC) 		5 LEU A 272
GLY A 102
GLN A 149
ILE A 348
LEU A 118
 None
None
None
CL  A 467 (-4.6A)
None
 1.24A 5y2tA-3nd0A:
undetectable		 5y2tA-3nd0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 LEU A 886
PHE A 461
GLY A 935
MET A 486
LEU A 478
 None
 0.94A 5y2tA-3ne5A:
undetectable		 5y2tA-3ne5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogg BOTULINUM NEUROTOXIN
TYPE D

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 LEU A1191
PHE A1221
GLN A1219
LEU A1093
ILE A1101
 None
 1.08A 5y2tA-3oggA:
undetectable		 5y2tA-3oggA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 LEU B 797
GLY B 911
LEU B 866
ILE B 859
LEU B1010
 None
 1.24A 5y2tA-3p8cB:
undetectable		 5y2tA-3p8cB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		5 LEU A 153
GLY A 177
GLN A  75
ILE A 194
LEU A  79
 None
None
LLP  A 207 ( 4.7A)
None
None
 1.23A 5y2tA-3pj0A:
undetectable		 5y2tA-3pj0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qkw NUCLEOTIDE SUGAR
SYNTHETASE-LIKE
PROTEIN

(Streptococcus
parasanguinis) 		no annotation 5 TYR A 238
LEU A 105
ILE A 118
MET A 143
MET A 134
 None
 1.09A 5y2tA-3qkwA:
undetectable		 5y2tA-3qkwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF03320
(FBPase_glpX) 		5 TYR A 279
LEU A 284
ILE A 228
MET A 132
LEU A 267
 None
 1.22A 5y2tA-3rplA:
undetectable		 5y2tA-3rplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sv0 CASEIN KINASE I-LIKE

(Oryza sativa) 		PF00069
(Pkinase) 		5 LEU A 211
TYR A 266
LEU A 269
HIS A 120
LEU A 125
 None
 1.23A 5y2tA-3sv0A:
undetectable		 5y2tA-3sv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7f UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF16420
(ATG7_N) 		5 LEU A 281
PHE A  13
GLY A 141
LEU A  17
LEU A  46
 None
 1.25A 5y2tA-3t7fA:
undetectable		 5y2tA-3t7fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A 341
PHE A 336
LEU A  36
ILE A  21
LEU A 316
 None
 1.23A 5y2tA-3u95A:
undetectable		 5y2tA-3u95A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umg HALOACID
DEHALOGENASE

(Rhodococcus
jostii) 		PF00702
(Hydrolase) 		5 PHE A  23
GLY A  24
LEU A 125
ILE A 212
LEU A 144
 CL  A 255 ( 4.8A)
None
None
None
None
 1.12A 5y2tA-3umgA:
undetectable		 5y2tA-3umgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vh1 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME ATG7

(Saccharomyces
cerevisiae) 		PF00899
(ThiF)
PF16420
(ATG7_N) 		5 LEU A 281
PHE A  13
GLY A 141
LEU A  17
LEU A  46
 None
 1.23A 5y2tA-3vh1A:
undetectable		 5y2tA-3vh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 PHE A  72
GLY A 365
LEU A 297
ILE A 283
HIS A 357
 CUO  A 708 (-4.6A)
None
None
None
CUO  A 708 (-3.3A)
 1.27A 5y2tA-3wkyA:
undetectable		 5y2tA-3wkyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 TYR A 300
ILE A 215
MET A 172
HIS A 260
LEU A 257
 None
 1.25A 5y2tA-3zh4A:
undetectable		 5y2tA-3zh4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzn BACTERIOCIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14859
(Colicin_M) 		5 PHE A  72
TYR A  54
LEU A  47
ILE A 117
LEU A 249
 None
 1.23A 5y2tA-4fznA:
undetectable		 5y2tA-4fznA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		5 LEU A 274
GLY A 111
LEU A 137
MET A  94
LEU A 167
 None
 1.21A 5y2tA-4g3hA:
undetectable		 5y2tA-4g3hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Rhodopseudomonas
palustris;
Paraburkholderia
xenovorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 199
PHE A 212
GLY A 210
MET A 307
LEU A 175
 None
None
None
CO3  A 608 (-4.4A)
None
 1.09A 5y2tA-4gxrA:
undetectable		 5y2tA-4gxrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifq NUCLEOPORIN NUP192

(Saccharomyces
cerevisiae) 		PF11894
(Nup192) 		5 LEU A 216
PHE A 229
LEU A 114
ILE A 144
LEU A 360
 None
 1.22A 5y2tA-4ifqA:
undetectable		 5y2tA-4ifqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9u TRK SYSTEM POTASSIUM
UPTAKE PROTEIN TRKH

(Vibrio
parahaemolyticus) 		PF02386
(TrkH) 		5 PHE A 137
GLY A 139
LEU A 190
ILE A 218
LEU A  16
 None
 1.01A 5y2tA-4j9uA:
undetectable		 5y2tA-4j9uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwv SHORT CHAIN
ENOYL-COA HYDRATASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 PHE A 110
GLY A 108
LEU A  53
ILE A  27
LEU A 175
 None
 1.02A 5y2tA-4jwvA:
undetectable		 5y2tA-4jwvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mqj HEMOGLOBIN SUBUNIT
GAMMA-2

(Homo sapiens) 		PF00042
(Globin) 		5 LEU B  81
GLY B  72
LEU B 114
ILE B  11
MET B 133
 None
 1.25A 5y2tA-4mqjB:
undetectable		 5y2tA-4mqjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		5 LEU A  87
GLY A  42
LEU A  23
ILE A  59
LEU A 265
 None
KPI  A 160 ( 3.5A)
None
None
None
 1.19A 5y2tA-4nq1A:
undetectable		 5y2tA-4nq1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqg GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
pneumoniae) 		PF00534
(Glycos_transf_1) 		5 LEU A 237
GLY A 225
GLN A 198
LEU A  65
ILE A   6
 None
 1.13A 5y2tA-4pqgA:
undetectable		 5y2tA-4pqgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		5 LEU A 650
GLN A 620
LEU A 756
ILE A 699
LEU A 805
 None
 1.18A 5y2tA-4q8hA:
undetectable		 5y2tA-4q8hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 GLY A 142
GLN A  88
LEU A  76
ILE A 131
MET A 127
 None
 0.94A 5y2tA-4qfuA:
undetectable		 5y2tA-4qfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 GLY A 142
LEU A  76
ILE A 131
MET A 127
MET A  63
 None
 1.04A 5y2tA-4qfuA:
undetectable		 5y2tA-4qfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		6 LEU A 168
GLY A 142
GLN A  88
TYR A  75
LEU A  76
ILE A 131
 None
 1.17A 5y2tA-4qfuA:
undetectable		 5y2tA-4qfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w91 AMINOTRANSFERASE

(Brucella suis) 		PF00266
(Aminotran_5) 		5 LEU A 206
PHE A 230
GLY A 209
ILE A 191
LEU A 298
 None
 1.22A 5y2tA-4w91A:
undetectable		 5y2tA-4w91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		5 LEU A  63
GLY A 121
ILE A 146
MET A 299
HIS A 281
 None
 1.24A 5y2tA-4zwnA:
undetectable		 5y2tA-4zwnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE

(Escherichia
coli) 		PF01928
(CYTH) 		5 GLY A 400
GLN A 399
LEU A 369
ILE A 413
LEU A 380
 None
 1.20A 5y2tA-5a60A:
undetectable		 5y2tA-5a60A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5z PTLCIB4 H88A MUTANT

(Phaeodactylum
tricornutum) 		no annotation 5 PHE A 248
GLY A 229
LEU A  54
ILE A 231
LEU A  29
 None
 1.22A 5y2tA-5b5zA:
undetectable		 5y2tA-5b5zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doz JAMJ

(Lyngbya
majuscula) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 PHE A  73
GLY A  74
LEU A  24
ILE A  38
MET A 334
 None
 1.26A 5y2tA-5dozA:
undetectable		 5y2tA-5dozA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsy POLY [ADP-RIBOSE]
POLYMERASE 2

(Homo sapiens) 		PF00644
(PARP) 		5 PHE A 444
GLY A 445
TYR A 460
ILE A 432
LEU A 541
 None
None
UHB  A1001 (-3.4A)
None
None
 1.01A 5y2tA-5dsyA:
undetectable		 5y2tA-5dsyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		5 LEU A 135
GLY A  81
CYH A  82
TYR A  89
ILE A  78
 None
SAM  A 301 (-3.3A)
None
None
None
 1.18A 5y2tA-5e9qA:
undetectable		 5y2tA-5e9qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5d 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00701
(DHDPS) 		5 LEU A 141
PHE A 210
GLY A 194
LEU A 177
LEU A 225
 None
None
6GT  A 403 (-4.2A)
None
None
 1.24A 5y2tA-5j5dA:
undetectable		 5y2tA-5j5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 PHE A 195
GLN A 194
LEU A  87
MET A 102
LEU A 490
 None
 1.22A 5y2tA-5kf7A:
undetectable		 5y2tA-5kf7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 LEU A 101
PHE A  26
GLY A 126
LEU A 171
LEU A 218
 None
 1.23A 5y2tA-5kreA:
undetectable		 5y2tA-5kreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 LEU A 104
PHE A  26
LEU A 229
ILE A 118
LEU A 218
 None
 1.25A 5y2tA-5kreA:
undetectable		 5y2tA-5kreA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lv9 THERMOPHILIC
TRYPTOPHAN
HALOGENASE

(Streptomyces
violaceusniger) 		PF04820
(Trp_halogenase) 		5 LEU A 179
PHE A  49
GLY A 362
MET A  16
LEU A 456
 None
 1.26A 5y2tA-5lv9A:
undetectable		 5y2tA-5lv9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg8 STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
6

(Schizosaccharomyces
pombe) 		no annotation 5 LEU B 590
PHE B 528
GLY B 551
LEU B 640
ILE B 580
 None
 1.28A 5y2tA-5mg8B:
undetectable		 5y2tA-5mg8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 GLY A 144
GLN A  90
LEU A  78
ILE A 133
MET A 129
 None
NH3  A 504 ( 4.4A)
None
None
None
 0.72A 5y2tA-5msyA:
undetectable		 5y2tA-5msyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		6 LEU A 170
GLY A 144
GLN A  90
TYR A  77
LEU A  78
ILE A 133
 None
None
NH3  A 504 ( 4.4A)
None
None
None
 1.10A 5y2tA-5msyA:
undetectable		 5y2tA-5msyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 LEU A 278
PHE A 385
GLY A 401
TYR A 253
ILE A 397
 None
 1.27A 5y2tA-5ncsA:
undetectable		 5y2tA-5ncsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A 426
GLY A 403
GLN A 486
LEU A  45
ILE A 448
 None
 1.10A 5y2tA-5vniA:
undetectable		 5y2tA-5vniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		5 LEU A 497
GLY A 492
GLN A 488
LEU A 574
LEU A 407
 None
 1.26A 5y2tA-5wgxA:
undetectable		 5y2tA-5wgxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		5 GLY A1117
TYR A 903
LEU A 902
ILE A1070
MET A1093
 None
 1.28A 5y2tA-5wvrA:
undetectable		 5y2tA-5wvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 235
PHE A 152
LEU A 264
ILE A 240
HIS A  61
 None
KCX  A 150 ( 4.0A)
None
None
ZN  A 502 (-3.3A)
 1.28A 5y2tA-5ykdA:
undetectable		 5y2tA-5ykdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 5 LEU A  19
GLY A  59
TYR A 219
ILE A  74
HIS A 299
 None
 1.11A 5y2tA-5yo8A:
undetectable		 5y2tA-5yo8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 PHE A 992
GLY A1099
TYR A 744
LEU A 740
LEU A 627
 None
 1.24A 5y2tA-6a91A:
undetectable		 5y2tA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 5 GLY A 120
TYR A  92
LEU A 116
ILE A 211
LEU A  52
 None
 1.22A 5y2tA-6ap6A:
undetectable		 5y2tA-6ap6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gii CYTOCHROME P450

(Tepidiphilus
thermophilus) 		no annotation 5 LEU A 151
PHE A 412
GLY A 421
ILE A 305
LEU A 349
 HEM  A 501 (-3.7A)
HEM  A 501 (-3.7A)
HEM  A 501 (-3.5A)
HEM  A 501 ( 4.4A)
None
 1.21A 5y2tA-6giiA:
undetectable		 5y2tA-6giiA:
undetectable