SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y2O_A_8N6A501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		5 CYH L 492
HIS L 498
HIS L  77
LEU L 428
LEU L 449
 NI  L 500 (-2.4A)
FE2  L 501 (-3.5A)
FCO  L 499 (-3.9A)
FCO  L 499 (-3.5A)
None
 1.31A 5y2oA-1cc1L:
0.0		 5y2oA-1cc1L:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdk FUMARATE HYDRATASE
CLASS II

(Thermus
thermophilus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 TYR A 161
LEU A 212
HIS A 157
LEU A 256
LEU A 222
 None
 1.48A 5y2oA-1vdkA:
1.8		 5y2oA-1vdkA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8d HYPOTHETICAL PROTEIN
YIIL

(Escherichia
coli) 		PF05336
(rhaM) 		5 HIS A  22
LEU A  33
PHE A   6
LEU A  52
TYR A  18
 RNS  A1105 (-3.9A)
None
None
None
RNS  A1105 (-4.5A)
 1.18A 5y2oA-1x8dA:
undetectable		 5y2oA-1x8dA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnf LIPOPROTEIN NLPI

(Escherichia
coli) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		5 PHE A 257
TYR A 141
PHE A 238
LEU A 245
LEU A 280
 None
 1.17A 5y2oA-1xnfA:
0.0		 5y2oA-1xnfA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0k HYPOTHETICAL PROTEIN
PA4535

(Pseudomonas
aeruginosa) 		PF08682
(DUF1780) 		5 PHE A  70
LEU A 147
LEU A 122
LEU A 183
TYR A 164
 None
 1.38A 5y2oA-1y0kA:
undetectable		 5y2oA-1y0kA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		5 PHE A 299
HIS A 275
LEU A 332
PHE A 298
LEU A 290
 None
FE  A 402 (-3.4A)
None
None
None
 1.33A 5y2oA-1y3tA:
undetectable		 5y2oA-1y3tA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1s HYPOTHETICAL PROTEIN
PA3332

(Pseudomonas
aeruginosa) 		PF12680
(SnoaL_2) 		5 PHE A  84
LEU A  62
PHE A  66
LEU A   7
TYR A 115
 None
None
PGE  A 301 (-4.8A)
None
PGE  A 301 (-4.6A)
 1.21A 5y2oA-1z1sA:
0.3		 5y2oA-1z1sA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		5 SER A 211
LEU A 187
PHE A  89
LEU A 131
LEU A 231
 SO4  A1000 ( 3.9A)
None
None
None
None
 1.44A 5y2oA-2c3zA:
0.0		 5y2oA-2c3zA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c40 INOSINE-URIDINE
PREFERRING
NUCLEOSIDE HYDROLASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF01156
(IU_nuc_hydro) 		5 PHE A 300
PHE A 299
LEU A 204
LEU A 224
TYR A 228
 None
 1.24A 5y2oA-2c40A:
undetectable		 5y2oA-2c40A:
15.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2daw RWD DOMAIN
CONTAINING PROTEIN 2

(Homo sapiens) 		PF05773
(RWD) 		5 LEU A  44
PHE A  64
LEU A  92
LEU A 125
TYR A  87
 None
 1.28A 5y2oA-2dawA:
undetectable		 5y2oA-2dawA:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 CYH A 276
SER A 280
LEU A 321
MET A 355
HIS A 440
LEU A 460
TYR A 464
 735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.0A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.72A 5y2oA-2p54A:
37.5		 5y2oA-2p54A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p54 PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 PHE A 273
CYH A 276
SER A 280
LEU A 321
MET A 355
LEU A 460
TYR A 464
 735  A 469 (-3.7A)
735  A 469 (-2.9A)
735  A 469 (-2.8A)
735  A 469 ( 4.3A)
735  A 469 (-2.9A)
735  A 469 (-4.3A)
735  A 469 (-4.6A)
 0.82A 5y2oA-2p54A:
37.5		 5y2oA-2p54A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5x N-ACETYLSEROTONIN
O-METHYLTRANSFERASE-
LIKE PROTEIN

(Homo sapiens) 		PF02545
(Maf) 		5 PHE A 204
HIS A 129
LEU A  10
LEU A 211
TYR A 212
 None
 1.29A 5y2oA-2p5xA:
undetectable		 5y2oA-2p5xA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcs CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF06240
(COXG) 		5 PHE A 136
PHE A 137
LEU A  20
LEU A  76
TYR A  74
 UNL  A 161 (-4.2A)
UNL  A 161 ( 4.9A)
UNL  A 161 (-4.7A)
UNL  A 161 (-4.8A)
UNL  A 161 (-4.3A)
 1.30A 5y2oA-2pcsA:
undetectable		 5y2oA-2pcsA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6k PHOSPHOTIDYLINOSITOL
3 KINASE 59F

(Drosophila
melanogaster) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka) 		5 PHE A 860
CYH A 791
LEU A 811
MET A 845
LEU A 925
 None
 1.27A 5y2oA-2x6kA:
undetectable		 5y2oA-2x6kA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		5 TYR B 390
LEU B 393
PHE B 363
LEU B 324
LEU B 334
 None
 1.17A 5y2oA-2xwuB:
undetectable		 5y2oA-2xwuB:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6b BASEPLATE STRUCTURAL
PROTEIN GP27

(Escherichia
virus T4) 		PF09096
(Phage-tail_2)
PF09097
(Phage-tail_1) 		5 PHE D 234
CYH D 310
LEU D 318
PHE D 326
MET D 211
 None
 1.03A 5y2oA-2z6bD:
undetectable		 5y2oA-2z6bD:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 PHE B 233
LEU B 171
PHE B 202
LEU B 251
LEU B 216
 None
 1.36A 5y2oA-2z7xB:
undetectable		 5y2oA-2z7xB:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aat ASPARTATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		5 CYH A 270
SER A 254
LEU A 112
LEU A 250
LEU A  87
 None
 1.45A 5y2oA-3aatA:
undetectable		 5y2oA-3aatA:
10.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
LEU A 330
PHE A 363
MET A 364
LEU A 453
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-4.4A)
None
MC5  A   1 (-3.7A)
MC5  A   1 (-4.2A)
 0.90A 5y2oA-3b0qA:
40.9		 5y2oA-3b0qA:
73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 PHE A 282
CYH A 285
MET A 364
HIS A 449
LEU A 465
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
None
 1.50A 5y2oA-3b0qA:
40.9		 5y2oA-3b0qA:
73.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b0q PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		11 PHE A 282
CYH A 285
SER A 289
HIS A 323
TYR A 327
LEU A 330
MET A 364
HIS A 449
LEU A 453
LEU A 469
TYR A 473
 MC5  A   1 (-4.4A)
MC5  A   1 (-3.6A)
MC5  A   1 (-2.6A)
MC5  A   1 (-3.8A)
None
MC5  A   1 (-4.4A)
MC5  A   1 (-3.7A)
MC5  A   1 (-3.9A)
MC5  A   1 (-4.2A)
MC5  A   1 (-4.1A)
MC5  A   1 (-4.9A)
 0.57A 5y2oA-3b0qA:
40.9		 5y2oA-3b0qA:
73.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bk5 PUTATIVE OUTER
MEMBRANE
LIPOPROTEIN-SORTING
PROTEIN

(Vibrio
parahaemolyticus) 		PF17131
(LolA_like) 		5 SER A 106
LEU A 211
PHE A  58
LEU A  83
TYR A 110
 None
 1.36A 5y2oA-3bk5A:
undetectable		 5y2oA-3bk5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bk5 PUTATIVE OUTER
MEMBRANE
LIPOPROTEIN-SORTING
PROTEIN

(Vibrio
parahaemolyticus) 		PF17131
(LolA_like) 		5 SER A 106
LEU A 211
PHE A  58
MET A  40
LEU A  83
 None
 1.06A 5y2oA-3bk5A:
undetectable		 5y2oA-3bk5A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 CYH A 285
HIS A 323
LEU A 330
HIS A 449
LEU A 469
TYR A 473
 L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
L41  A 501 (-3.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.63A 5y2oA-3d5fA:
36.5		 5y2oA-3d5fA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5f PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 PHE A 282
CYH A 285
HIS A 323
LEU A 330
LEU A 469
TYR A 473
 L41  A 501 ( 4.9A)
L41  A 501 (-3.5A)
L41  A 501 (-3.8A)
L41  A 501 (-4.9A)
L41  A 501 (-3.8A)
L41  A 501 (-4.8A)
 0.70A 5y2oA-3d5fA:
36.5		 5y2oA-3d5fA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 PHE A 123
SER A 330
HIS A  88
PHE A  97
LEU A 303
 None
 1.31A 5y2oA-3dy5A:
undetectable		 5y2oA-3dy5A:
5.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 CYH D 285
TYR D 327
LEU D 330
MET D 364
HIS D 449
 PLB  D 701 (-3.2A)
None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
 0.94A 5y2oA-3dzuD:
37.7		 5y2oA-3dzuD:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 PHE D 282
SER D 289
LEU D 330
MET D 364
LEU D 469
TYR D 473
 None
PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
None
 0.61A 5y2oA-3dzuD:
37.7		 5y2oA-3dzuD:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 SER D 289
LEU D 330
MET D 364
HIS D 449
LEU D 469
TYR D 473
 PLB  D 701 ( 3.9A)
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
None
None
 0.67A 5y2oA-3dzuD:
37.7		 5y2oA-3dzuD:
35.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		6 TYR D 327
LEU D 330
MET D 364
HIS D 449
LEU D 469
TYR D 473
 None
PLB  D 701 ( 4.1A)
PLB  D 701 ( 4.8A)
None
None
None
 0.90A 5y2oA-3dzuD:
37.7		 5y2oA-3dzuD:
35.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		5 SER A 444
PHE A  34
LEU A 505
LEU A 425
TYR A 510
 None
 1.26A 5y2oA-3f6tA:
undetectable		 5y2oA-3f6tA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 CYH A 246
PHE A 237
MET A 215
LEU A 260
LEU A 283
 None
 1.42A 5y2oA-3fxiA:
undetectable		 5y2oA-3fxiA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		5 PHE A 142
LEU A 173
LEU A  76
LEU A  83
TYR A  80
 None
 1.26A 5y2oA-3hfwA:
undetectable		 5y2oA-3hfwA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3put HYPOTHETICAL
CONSERVED PROTEIN

(Rhizobium etli) 		PF08327
(AHSA1) 		5 PHE A  25
LEU A 143
PHE A 108
MET A 117
TYR A  77
 None
HEZ  A 167 (-4.5A)
None
None
None
 1.19A 5y2oA-3putA:
undetectable		 5y2oA-3putA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqc DNA-DIRECTED RNA
POLYMERASE SUBUNIT
B, DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A', DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''

(Pyrococcus
furiosus) 		PF04560
(RNA_pol_Rpb2_7)
PF04997
(RNA_pol_Rpb1_1) 		5 LEU A  77
PHE A 135
MET A  85
LEU A 365
TYR A 343
 None
 1.25A 5y2oA-3qqcA:
undetectable		 5y2oA-3qqcA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sv0 CASEIN KINASE I-LIKE

(Oryza sativa) 		PF00069
(Pkinase) 		5 TYR A 266
LEU A 269
HIS A 120
LEU A 125
TYR A 156
 None
 1.43A 5y2oA-3sv0A:
undetectable		 5y2oA-3sv0A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 LEU A 531
PHE A 650
MET A 638
LEU A 655
LEU A 550
 None
 1.49A 5y2oA-3ttfA:
undetectable		 5y2oA-3ttfA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 PHE A 214
HIS A 301
LEU A 200
PHE A 211
LEU A 330
 None
 1.31A 5y2oA-3wfzA:
undetectable		 5y2oA-3wfzA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		5 PHE A 227
SER A  73
LEU A  67
LEU A 701
LEU A 668
 None
 1.29A 5y2oA-3wonA:
undetectable		 5y2oA-3wonA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 CYH B 489
HIS B 495
HIS B  82
LEU B 425
LEU B 446
 NI  B 501 ( 2.2A)
FE2  B 502 (-3.5A)
FCO  B 500 (-4.3A)
FCO  B 500 (-3.5A)
None
 1.35A 5y2oA-3ze7B:
undetectable		 5y2oA-3ze7B:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE A 346
SER A 147
LEU A 242
PHE A 287
LEU A 385
 None
 1.49A 5y2oA-4bziA:
undetectable		 5y2oA-4bziA:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0d CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		5 PHE A2023
CYH A2020
PHE A2047
MET A2051
LEU A1967
 None
 1.22A 5y2oA-4c0dA:
undetectable		 5y2oA-4c0dA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doo CHALCONE-FLAVANONE
ISOMERASE FAMILY
PROTEIN

(Arabidopsis
thaliana) 		PF16035
(Chalcone_2) 		5 PHE A 130
SER A 110
LEU A 148
LEU A 180
TYR A 181
 None
DAO  A 301 (-2.8A)
None
None
None
 1.10A 5y2oA-4dooA:
undetectable		 5y2oA-4dooA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 5 PHE A  27
CYH A  26
SER A  94
LEU A 269
LEU A 119
 None
 1.28A 5y2oA-4l9aA:
undetectable		 5y2oA-4l9aA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Chaetomium
thermophilum) 		PF08662
(eIF2A) 		5 SER A 547
HIS A 610
LEU A 618
LEU A 549
TYR A 612
 None
 1.47A 5y2oA-4noxA:
undetectable		 5y2oA-4noxA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txa ROQUIN-1

(Mus musculus) 		PF13445
(zf-RING_UBOX) 		5 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.37A 5y2oA-4txaA:
undetectable		 5y2oA-4txaA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 CYH A 189
SER A 187
LEU A 145
LEU A 139
TYR A 141
 None
SO4  A 501 ( 4.6A)
None
None
None
 1.13A 5y2oA-4xguA:
undetectable		 5y2oA-4xguA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		5 LEU B 176
MET B 280
LEU B 289
LEU B 202
TYR B 293
 None
 1.45A 5y2oA-4zxsB:
undetectable		 5y2oA-4zxsB:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		5 PHE B 222
SER B 202
LEU B 167
LEU B 254
LEU B 282
 None
 1.45A 5y2oA-5a7vB:
undetectable		 5y2oA-5a7vB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec3 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Homo sapiens) 		PF00903
(Glyoxalase)
PF13669
(Glyoxalase_4) 		5 PHE A  42
LEU A 346
PHE A  69
LEU A 178
LEU A 286
 PHE  A  42 ( 1.3A)
LEU  A 346 ( 0.6A)
PHE  A  69 ( 1.3A)
LEU  A 178 ( 0.6A)
LEU  A 286 ( 0.6A)
 1.35A 5y2oA-5ec3A:
undetectable		 5y2oA-5ec3A:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF04054
(Not1) 		5 PHE A2023
CYH A2020
PHE A2047
MET A2051
LEU A1967
 None
 1.09A 5y2oA-5fu7A:
undetectable		 5y2oA-5fu7A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 LEU A 536
PHE A 549
MET A 546
LEU A 510
LEU A 566
 None
 1.22A 5y2oA-5hdtA:
undetectable		 5y2oA-5hdtA:
5.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		5 HIS A 267
TYR A 265
LEU A 215
LEU A 180
TYR A 217
 None
 1.40A 5y2oA-5hy7A:
undetectable		 5y2oA-5hy7A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 PHE A 232
HIS A  96
LEU A 174
LEU A 130
TYR A 128
 None
 1.42A 5y2oA-5jd5A:
undetectable		 5y2oA-5jd5A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		5 HIS A  82
LEU A  38
LEU A 161
LEU A 116
TYR A 114
 None
 1.24A 5y2oA-5l2pA:
undetectable		 5y2oA-5l2pA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tph DE NOVO NTF2
HOMODIMER

(synthetic
construct) 		PF12680
(SnoaL_2) 		5 LEU A  55
PHE A  91
MET A  89
LEU A  13
LEU A  29
 None
 1.33A 5y2oA-5tphA:
undetectable		 5y2oA-5tphA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 PHE A1279
LEU A1315
PHE A1455
LEU A1438
LEU A1478
 None
 1.18A 5y2oA-5u89A:
undetectable		 5y2oA-5u89A:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN UL130
ENVELOPE
GLYCOPROTEIN UL131A

(Human
betaherpesvirus
5) 		PF11668
(Gp_UL130)
no annotation 		5 PHE E 122
SER D 178
MET D 125
LEU E  56
LEU D 176
 None
 1.42A 5y2oA-5vocE:
undetectable		 5y2oA-5vocE:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 5 CYH A 445
TYR A 430
MET A 410
LEU A 418
LEU A 485
 None
 1.39A 5y2oA-6d0sA:
undetectable		 5y2oA-6d0sA:
26.60