SIMILAR PATTERNS OF AMINO ACIDS FOR 5Y1Y_A_HNQA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		4 VAL A 437
LEU A 268
LEU A 263
ILE A 390
 None
 0.81A 5y1yA-1ddgA:
undetectable		 5y1yA-1ddgA:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1e6i TRANSCRIPTIONAL
ACTIVATOR GCN5

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		5 PRO A 351
VAL A 356
CYH A 403
TYR A 406
ASN A 407
 None
 0.65A 5y1yA-1e6iA:
16.0		 5y1yA-1e6iA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef4 DNA-DIRECTED RNA
POLYMERASE

(Methanothermobacter
thermautotrophicus) 		PF01194
(RNA_pol_N) 		4 PRO A  30
LEU A  37
LEU A  39
ILE A  49
 None
 0.91A 5y1yA-1ef4A:
undetectable		 5y1yA-1ef4A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1im4 DBH

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		5 PRO A 185
LEU A 179
LEU A 176
ASN A 148
ILE A 150
 None
 1.25A 5y1yA-1im4A:
undetectable		 5y1yA-1im4A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0p INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA) 		4 VAL A 157
LEU A 295
LEU A 298
TYR A 166
 None
 0.92A 5y1yA-1t0pA:
undetectable		 5y1yA-1t0pA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9j PROBABLE BUTYRATE
KINASE 2

(Thermotoga
maritima) 		PF00871
(Acetate_kinase) 		4 VAL A 126
LEU A  78
TYR A 355
ILE A  93
 None
 0.91A 5y1yA-1x9jA:
undetectable		 5y1yA-1x9jA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnt PROTEIN (DNA-REPAIR
PROTEIN XRCC1)

(Homo sapiens) 		PF01834
(XRCC1_N) 		4 VAL A 128
LEU A  47
LEU A   6
ILE A  60
 None
 0.91A 5y1yA-1xntA:
undetectable		 5y1yA-1xntA:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dvr BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		8 PRO A  32
VAL A  37
LEU A  42
LEU A  44
CYH A  86
TYR A  89
ASN A  90
ILE A  96
 None
 0.38A 5y1yA-2dvrA:
20.3		 5y1yA-2dvrA:
65.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6n BROMODOMAIN PHD
FINGER TRANSCRIPTION
FACTOR

(Homo sapiens) 		PF00439
(Bromodomain)
PF00628
(PHD) 		4 VAL A  97
CYH A 144
TYR A 147
ASN A 148
 None
 0.50A 5y1yA-2f6nA:
16.3		 5y1yA-2f6nA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9b CALBINDIN

(Rattus
norvegicus) 		PF13405
(EF-hand_6)
PF13499
(EF-hand_7) 		4 VAL A  81
LEU A  78
TYR A  65
ILE A  40
 None
 0.90A 5y1yA-2g9bA:
undetectable		 5y1yA-2g9bA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PRO A 412
LEU A 401
LEU A 398
ASN A 362
 None
 0.85A 5y1yA-2gskA:
undetectable		 5y1yA-2gskA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h00 METHYLTRANSFERASE 10
DOMAIN CONTAINING
PROTEIN

(Homo sapiens) 		PF05971
(Methyltransf_10) 		4 VAL A  42
LEU A  83
CYH A  20
ILE A  31
 None
 0.88A 5y1yA-2h00A:
undetectable		 5y1yA-2h00A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho9 CHEMOTAXIS PROTEIN
CHEW

(Escherichia
coli) 		PF01584
(CheW) 		4 VAL A 102
LEU A  71
TYR A  29
ILE A  31
 None
 0.89A 5y1yA-2ho9A:
undetectable		 5y1yA-2ho9A:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l5e BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Mus musculus) 		PF00439
(Bromodomain) 		5 PRO A  58
CYH A 112
TYR A 115
ASN A 116
ILE A 122
 None
 0.77A 5y1yA-2l5eA:
17.1		 5y1yA-2l5eA:
77.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l5e BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Mus musculus) 		PF00439
(Bromodomain) 		4 PRO A  58
LEU A  68
LEU A  70
ASN A 116
 None
 0.71A 5y1yA-2l5eA:
17.1		 5y1yA-2l5eA:
77.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l5e BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Mus musculus) 		PF00439
(Bromodomain) 		4 PRO A  58
LEU A  70
CYH A 112
ASN A 116
 None
 0.79A 5y1yA-2l5eA:
17.1		 5y1yA-2l5eA:
77.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ld7 HISTONE DEACETYLASE
COMPLEX SUBUNIT
SAP30
PAIRED AMPHIPATHIC
HELIX PROTEIN SIN3A

(Mus musculus) 		PF02671
(PAH)
PF13867
(SAP30_Sin3_bdg) 		4 VAL A 182
LEU A 150
LEU A 153
ILE B 490
 None
 0.83A 5y1yA-2ld7A:
undetectable		 5y1yA-2ld7A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbg RALA-BINDING PROTEIN
1

(Homo sapiens) 		PF00620
(RhoGAP) 		4 VAL A 350
LEU A 278
LEU A 279
ILE A 322
 None
 0.77A 5y1yA-2mbgA:
undetectable		 5y1yA-2mbgA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 PRO A 605
CYH A 637
TYR A 640
ILE A 653
 None
 0.69A 5y1yA-2okxA:
undetectable		 5y1yA-2okxA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 PRO A 329
VAL A 333
LEU A 365
ILE A 406
 None
 0.87A 5y1yA-2pqdA:
undetectable		 5y1yA-2pqdA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0s CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 CYH A 130
TYR A 133
ASN A 134
ILE A 140
 None
 0.41A 5y1yA-2r0sA:
12.5		 5y1yA-2r0sA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0v CHROMATIN
STRUCTURE-REMODELING
COMPLEX PROTEIN RSC4

(Saccharomyces
cerevisiae) 		PF00439
(Bromodomain) 		4 CYH A 130
TYR A 133
ASN A 134
ILE A 140
 ALY  A  25 ( 3.9A)
ALY  A  25 ( 4.7A)
ALY  A  25 ( 3.3A)
ALY  A  25 ( 4.3A)
 0.42A 5y1yA-2r0vA:
12.9		 5y1yA-2r0vA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvx PROTEIN A52

(Vaccinia virus) 		PF06227
(Poxvirus) 		4 VAL A 144
LEU A 100
LEU A 104
ILE A 119
 None
 0.84A 5y1yA-2vvxA:
undetectable		 5y1yA-2vvxA:
22.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		6 PRO A 293
VAL A 298
LEU A 305
CYH A 347
TYR A 350
ASN A 351
 None
 0.57A 5y1yA-2wp1A:
16.9		 5y1yA-2wp1A:
38.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wp1 BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Mus musculus) 		PF00439
(Bromodomain) 		6 VAL A 298
LEU A 303
LEU A 305
CYH A 347
TYR A 350
ASN A 351
 None
 0.50A 5y1yA-2wp1A:
16.9		 5y1yA-2wp1A:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 VAL B 817
LEU B 907
LEU B 813
ILE B 878
 None
 0.92A 5y1yA-2xwbB:
undetectable		 5y1yA-2xwbB:
9.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		7 PRO A  98
VAL A 103
LEU A 108
CYH A 152
TYR A 155
ASN A 156
ILE A 162
 EAM  A1188 (-4.6A)
EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 ( 4.3A)
None
EAM  A1188 (-3.2A)
EAM  A1188 (-3.8A)
 0.42A 5y1yA-2yekA:
19.9		 5y1yA-2yekA:
68.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2yek BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		7 PRO A  98
VAL A 103
LEU A 108
LEU A 110
CYH A 152
TYR A 155
ASN A 156
 EAM  A1188 (-4.6A)
EAM  A1188 (-4.4A)
EAM  A1188 ( 3.8A)
EAM  A1188 (-4.5A)
EAM  A1188 ( 4.3A)
None
EAM  A1188 (-3.2A)
 0.40A 5y1yA-2yekA:
19.9		 5y1yA-2yekA:
68.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdk SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Bacillus
subtilis) 		PF01144
(CoA_trans) 		4 VAL A  51
LEU A  63
LEU A  66
ILE A 155
 None
 0.92A 5y1yA-3cdkA:
undetectable		 5y1yA-3cdkA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		4 VAL A 247
LEU A 251
LEU A 253
ILE A 237
 None
 0.76A 5y1yA-3ctzA:
undetectable		 5y1yA-3ctzA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2j PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A 375
TYR A 430
ASN A 431
ILE A 437
 CL  A   2 ( 4.2A)
None
None
None
 0.50A 5y1yA-3k2jA:
13.8		 5y1yA-3k2jA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2k PUTATIVE
CARBOXYPEPTIDASE

(Burkholderia
mallei) 		PF00246
(Peptidase_M14) 		4 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.72A 5y1yA-3k2kA:
undetectable		 5y1yA-3k2kA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8i 30KLP

(Treponema
pallidum) 		no annotation 4 VAL A 187
LEU A  48
LEU A 189
ILE A 277
 None
 0.78A 5y1yA-3k8iA:
undetectable		 5y1yA-3k8iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 VAL A  75
LEU A 104
LEU A  77
ILE A  16
 None
 0.83A 5y1yA-3lq1A:
undetectable		 5y1yA-3lq1A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n26 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		4 VAL A 184
LEU A 205
TYR A 153
ILE A 160
 None
 0.83A 5y1yA-3n26A:
undetectable		 5y1yA-3n26A:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nxb CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A 458
VAL A 463
CYH A 510
TYR A 513
ASN A 514
 None
EDO  A   1 (-4.3A)
EDO  A   1 ( 3.9A)
None
EDO  A   1 (-3.3A)
 0.58A 5y1yA-3nxbA:
16.5		 5y1yA-3nxbA:
32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 LEU A 147
LEU A 143
CYH A  43
ILE A  39
 None
 0.89A 5y1yA-3pieA:
undetectable		 5y1yA-3pieA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6

(Homo sapiens) 		PF02146
(SIR2) 		4 PRO A 290
VAL A 102
LEU A 104
LEU A  99
 None
 0.86A 5y1yA-3pkjA:
undetectable		 5y1yA-3pkjA:
18.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q2e BROMODOMAIN AND WD
REPEAT-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A1337
VAL A1342
TYR A1392
ILE A1400
 None
None
ACT  A   1 ( 4.9A)
None
 0.66A 5y1yA-3q2eA:
16.4		 5y1yA-3q2eA:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ros NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Lactobacillus
acidophilus) 		PF00171
(Aldedh) 		4 LEU A 438
CYH A  92
TYR A  95
ILE A 139
 None
 0.89A 5y1yA-3rosA:
undetectable		 5y1yA-3rosA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgk AVR3A11

(Phytophthora
capsici) 		PF16810
(RXLR) 		4 VAL A  75
LEU A 110
LEU A 106
ILE A  82
 None
 0.86A 5y1yA-3zgkA:
undetectable		 5y1yA-3zgkA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aij TRANSCRIPTIONAL
REGULATOR SLYA

(Yersinia
pseudotuberculosis) 		PF01047
(MarR) 		4 PRO A  98
VAL A 103
LEU A  27
LEU A  29
 None
 0.93A 5y1yA-4aijA:
undetectable		 5y1yA-4aijA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 VAL A 212
LEU A 148
LEU A 137
ILE A 256
 None
 0.71A 5y1yA-4b6zA:
undetectable		 5y1yA-4b6zA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cri TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1

(Homo sapiens) 		PF09038
(53-BP1_Tudor) 		4 VAL A1491
LEU A1534
LEU A1602
TYR A1515
 None
 0.92A 5y1yA-4criA:
undetectable		 5y1yA-4criA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4w DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		4 PRO A 185
LEU A 176
ASN A 148
ILE A 150
 None
 0.92A 5y1yA-4f4wA:
undetectable		 5y1yA-4f4wA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 VAL A 147
LEU A 157
LEU A 159
ILE A 167
 VAL  A 147 ( 0.6A)
LEU  A 157 ( 0.6A)
LEU  A 159 ( 0.6A)
ILE  A 167 ( 0.7A)
 0.84A 5y1yA-4g9kA:
undetectable		 5y1yA-4g9kA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glx DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 VAL A 444
LEU A 474
LEU A 500
ILE A 458
 None
 0.76A 5y1yA-4glxA:
undetectable		 5y1yA-4glxA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		4 VAL A 311
LEU A 308
TYR A 343
ILE A 265
 None
 0.90A 5y1yA-4gz8A:
undetectable		 5y1yA-4gz8A:
10.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hbx BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		8 PRO A  82
VAL A  87
LEU A  92
LEU A  94
CYH A 136
TYR A 139
ASN A 140
ILE A 146
 14X  A 201 (-4.4A)
14X  A 201 (-4.7A)
14X  A 201 (-4.4A)
None
14X  A 201 ( 3.9A)
None
14X  A 201 (-3.1A)
14X  A 201 ( 4.0A)
 0.39A 5y1yA-4hbxA:
24.4		 5y1yA-4hbxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 PRO B  59
LEU B  80
LEU B  83
ILE B  64
 None
 0.87A 5y1yA-4hzuB:
undetectable		 5y1yA-4hzuB:
17.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ldf GCN5 LIKE ACETYLASE
+ BROMODOMAIN

(Cryptosporidium
parvum) 		PF00439
(Bromodomain) 		5 PRO A  32
VAL A  37
CYH A  84
TYR A  87
ASN A  88
 None
GOL  A 201 ( 4.9A)
GOL  A 201 ( 3.8A)
GOL  A 201 (-4.8A)
GOL  A 201 (-2.7A)
 0.63A 5y1yA-4ldfA:
15.2		 5y1yA-4ldfA:
33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 PRO A1110
VAL A1115
LEU A1120
TYR A1167
 None
 0.42A 5y1yA-4n3wA:
13.4		 5y1yA-4n3wA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3w CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 VAL A1115
LEU A1120
TYR A1167
ASN A1168
 None
 0.46A 5y1yA-4n3wA:
13.4		 5y1yA-4n3wA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nxj BROMODOMAIN PROTEIN

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 VAL A  35
CYH A  82
TYR A  85
ASN A  86
 None
 0.49A 5y1yA-4nxjA:
14.0		 5y1yA-4nxjA:
31.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E

(Aeropyrum
pernix) 		PF01040
(UbiA) 		5 PRO A  14
VAL A 137
LEU A  22
TYR A 163
ILE A 268
 None
 1.10A 5y1yA-4od5A:
undetectable		 5y1yA-4od5A:
14.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4py6 BROMODOMAIN PROTEIN,
PUTATIVE

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		4 VAL A1221
CYH A1274
ASN A1278
ILE A1287
 R78  A1401 ( 4.6A)
R78  A1401 ( 4.1A)
R78  A1401 (-3.2A)
R78  A1401 (-4.1A)
 0.60A 5y1yA-4py6A:
14.5		 5y1yA-4py6A:
30.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		4 VAL A  76
LEU A  11
LEU A  89
ILE A  66
 None
 0.88A 5y1yA-4tkmA:
undetectable		 5y1yA-4tkmA:
17.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyd BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		8 PRO A  82
VAL A  87
LEU A  92
LEU A  94
CYH A 136
TYR A 139
ASN A 140
ILE A 146
 V1T  A1171 (-4.2A)
V1T  A1171 (-4.9A)
V1T  A1171 (-3.8A)
None
V1T  A1171 ( 4.4A)
None
V1T  A1171 (-3.1A)
DMS  A1169 ( 4.3A)
 0.28A 5y1yA-4uydA:
24.2		 5y1yA-4uydA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uyg BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		7 PRO A 371
VAL A 376
LEU A 381
LEU A 383
CYH A 425
TYR A 428
ASN A 429
 None
73B  A1456 (-4.0A)
73B  A1456 (-4.9A)
73B  A1456 (-4.9A)
73B  A1456 (-3.3A)
None
73B  A1456 (-3.3A)
 0.48A 5y1yA-4uygA:
17.9		 5y1yA-4uygA:
35.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0g BLASTODERM-SPECIFIC
GENE 25A

(Drosophila
melanogaster) 		PF10523
(BEN) 		4 VAL A  92
LEU A  77
CYH A  85
ILE A  31
 None
 0.87A 5y1yA-4x0gA:
undetectable		 5y1yA-4x0gA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz3 ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		4 PRO A 328
VAL A 374
LEU A 377
ILE A 350
 None
 0.92A 5y1yA-4xz3A:
undetectable		 5y1yA-4xz3A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 LEU A1092
LEU A1094
CYH A1036
ILE A1045
 None
 0.90A 5y1yA-4yknA:
undetectable		 5y1yA-4yknA:
6.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4z93 BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		PF00439
(Bromodomain) 		7 PRO A 375
VAL A 380
LEU A 385
LEU A 387
CYH A 429
TYR A 432
ASN A 433
 4LD  A 501 (-3.9A)
4LD  A 501 ( 3.8A)
4LD  A 501 (-4.1A)
4LD  A 501 (-4.4A)
4LD  A 501 (-3.4A)
4LD  A 501 ( 3.9A)
4LD  A 501 (-2.8A)
 0.40A 5y1yA-4z93A:
17.8		 5y1yA-4z93A:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cqa BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A1893
CYH A1940
ASN A1944
ILE A1950
 2LY  A2001 ( 4.8A)
2LY  A2001 ( 4.3A)
2LY  A2001 (-3.2A)
2LY  A2001 ( 4.5A)
 0.55A 5y1yA-5cqaA:
15.7		 5y1yA-5cqaA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fg6 BROMODOMAIN-CONTAINI
NG PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A 591
CYH A 638
TYR A 641
ASN A 642
 5XE  A 705 (-3.9A)
5XE  A 705 (-3.6A)
5XE  A 705 (-4.8A)
5XE  A 705 (-3.3A)
 0.36A 5y1yA-5fg6A:
13.7		 5y1yA-5fg6A:
32.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h6y NUCLEOSOME-REMODELIN
G FACTOR SUBUNIT
BPTF

(Homo sapiens) 		no annotation 4 PRO A  92
VAL A  97
CYH A 144
TYR A 147
 None
 0.65A 5y1yA-5h6yA:
15.8		 5y1yA-5h6yA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h6y NUCLEOSOME-REMODELIN
G FACTOR SUBUNIT
BPTF

(Homo sapiens) 		no annotation 4 VAL A  97
CYH A 144
TYR A 147
ASN A 148
 None
 0.38A 5y1yA-5h6yA:
15.8		 5y1yA-5h6yA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hjc BROMODOMAIN-CONTAINI
NG PROTEIN 3

(Homo sapiens) 		PF00439
(Bromodomain) 		7 PRO A 333
VAL A 338
LEU A 343
LEU A 345
CYH A 387
TYR A 390
ASN A 391
 None
 0.53A 5y1yA-5hjcA:
18.1		 5y1yA-5hjcA:
39.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8g CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 PRO A1110
VAL A1115
LEU A1120
TYR A1167
 69E  A1404 (-3.7A)
69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-4.8A)
 0.60A 5y1yA-5i8gA:
16.1		 5y1yA-5i8gA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8g CREB-BINDING PROTEIN

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902) 		4 VAL A1115
LEU A1120
TYR A1167
ASN A1168
 69E  A1404 (-4.3A)
69E  A1404 (-4.2A)
69E  A1404 (-4.8A)
69E  A1404 (-3.0A)
 0.23A 5y1yA-5i8gA:
16.1		 5y1yA-5i8gA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izh RNA-DIRECTED RNA
POLYMERASE L

(Lassa
mammarenavirus) 		PF17296
(ArenaCapSnatch) 		4 PRO A  88
LEU A 126
LEU A 130
ILE A  72
 None
 0.90A 5y1yA-5izhA:
4.3		 5y1yA-5izhA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k66 NTA1P

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		4 PRO A 219
VAL A 387
LEU A 215
ILE A 105
 None
 0.87A 5y1yA-5k66A:
undetectable		 5y1yA-5k66A:
15.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ko4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF00439
(Bromodomain) 		4 LEU A  57
CYH A  99
TYR A 102
ASN A 103
 None
 0.50A 5y1yA-5ko4A:
14.6		 5y1yA-5ko4A:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkz HISTONE
ACETYLTRANSFERASE
P300,HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		5 PRO A1074
VAL A1079
LEU A1084
TYR A1131
ASN A1132
 None
 0.68A 5y1yA-5lkzA:
16.7		 5y1yA-5lkzA:
12.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lpk HISTONE
ACETYLTRANSFERASE
P300

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A1074
VAL A1079
LEU A1084
TYR A1131
ASN A1132
 XDM  A1201 (-3.9A)
XDM  A1201 (-4.7A)
XDM  A1201 ( 4.4A)
XDM  A1201 (-4.4A)
XDM  A1201 (-3.1A)
 0.61A 5y1yA-5lpkA:
17.0		 5y1yA-5lpkA:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 PRO A1527
VAL A1532
TYR A1582
ASN A1583
 7M8  A1704 (-3.8A)
7M8  A1704 (-3.5A)
7M8  A1704 ( 4.7A)
7M8  A1704 (-3.1A)
 0.52A 5y1yA-5mg2A:
13.1		 5y1yA-5mg2A:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ml0 HISTONE
ACETYLTRANSFERASE
KAT2B

(Mus musculus) 		no annotation 5 PRO A 746
VAL A 751
CYH A 798
TYR A 801
ASN A 802
 P2L  A 901 (-4.7A)
P2L  A 901 ( 4.2A)
P2L  A 901 ( 3.8A)
P2L  A 901 (-4.1A)
P2L  A 901 (-3.2A)
 0.83A 5y1yA-5ml0A:
15.7		 5y1yA-5ml0A:
32.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n13 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		4 VAL A 415
LEU A 420
CYH A 464
ASN A 468
 GOL  A 502 ( 4.0A)
GOL  A 501 ( 4.9A)
GOL  A 501 (-4.1A)
GOL  A 501 (-3.1A)
 0.65A 5y1yA-5n13A:
16.3		 5y1yA-5n13A:
36.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		5 PRO A 233
VAL A 238
CYH A 287
ASN A 291
ILE A 297
 IOD  A 405 ( 4.4A)
None
IOD  A 404 ( 4.5A)
IOD  A 404 (-3.9A)
IOD  A 404 ( 4.8A)
 0.37A 5y1yA-5n15A:
18.5		 5y1yA-5n15A:
36.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		5 PRO A 233
VAL A 238
LEU A 243
CYH A 287
ILE A 297
 IOD  A 405 ( 4.4A)
None
None
IOD  A 404 ( 4.5A)
IOD  A 404 ( 4.8A)
 0.48A 5y1yA-5n15A:
18.5		 5y1yA-5n15A:
36.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n15 BROMODOMAIN-CONTAINI
NG FACTOR 1

(Candida
albicans) 		PF00439
(Bromodomain) 		5 VAL A 238
LEU A 243
CYH A 287
ASN A 291
ILE A 297
 None
None
IOD  A 404 ( 4.5A)
IOD  A 404 (-3.9A)
IOD  A 404 ( 4.8A)
 1.11A 5y1yA-5n15A:
18.5		 5y1yA-5n15A:
36.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN

(Lactobacillus
reuteri) 		no annotation 4 VAL A 534
LEU A 536
LEU A 562
ILE A 526
 None
 0.90A 5y1yA-5nxkA:
undetectable		 5y1yA-5nxkA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o5a PEREGRIN

(Homo sapiens) 		no annotation 4 VAL A 657
CYH A 704
TYR A 707
ASN A 708
 9LN  A 802 ( 4.1A)
9LN  A 802 (-3.4A)
9LN  A 802 ( 4.7A)
9LN  A 802 (-3.2A)
 0.29A 5y1yA-5o5aA:
13.9		 5y1yA-5o5aA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A1893
CYH A1940
ASN A1944
ILE A1950
 None
None
EDO  A2001 (-3.2A)
EDO  A2001 ( 4.6A)
 0.57A 5y1yA-5pfrA:
15.6		 5y1yA-5pfrA:
29.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5pq9 BROMODOMAIN-CONTAINI
NG PROTEIN 1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A  59
CYH A 106
TYR A 109
ASN A 110
 EDO  A 202 (-4.5A)
EDO  A 202 (-3.4A)
EDO  A 201 (-4.7A)
EDO  A 201 (-3.2A)
 0.39A 5y1yA-5pq9A:
13.6		 5y1yA-5pq9A:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcm UNCHARACTERIZED
PROTEIN

(Leishmania
donovani) 		PF00439
(Bromodomain) 		5 VAL A  30
LEU A  37
CYH A  83
TYR A  86
ASN A  87
 R78  A 201 (-4.4A)
None
R78  A 201 ( 3.9A)
R78  A 201 (-4.5A)
R78  A 201 (-3.4A)
 0.78A 5y1yA-5tcmA:
11.5		 5y1yA-5tcmA:
25.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tpx HISTONE
ACETYLTRANSFERASE
GCN5

(Plasmodium
falciparum) 		PF00439
(Bromodomain) 		5 PRO A1380
VAL A1385
CYH A1432
TYR A1435
ASN A1436
 None
7H7  A1505 (-4.0A)
7H7  A1505 ( 3.7A)
None
7H7  A1505 (-3.1A)
 0.67A 5y1yA-5tpxA:
15.9		 5y1yA-5tpxA:
30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6v BROMODOMAIN-CONTAINI
NG PROTEIN 2

(Homo sapiens) 		no annotation 7 PRO A 371
VAL A 376
LEU A 381
LEU A 383
CYH A 425
TYR A 428
ASN A 429
 7WY  A 501 (-4.4A)
7WY  A 501 ( 4.5A)
7WY  A 501 (-4.9A)
None
7WY  A 501 ( 3.8A)
None
7WY  A 501 (-3.4A)
 0.39A 5y1yA-5u6vA:
18.1		 5y1yA-5u6vA:
41.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		5 PRO A1111
VAL A1116
LEU A1121
TYR A1168
ASN A1169
 None
 0.54A 5y1yA-5u7gA:
16.7		 5y1yA-5u7gA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9n BROMO DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00439
(Bromodomain) 		5 VAL A 332
LEU A 338
CYH A 409
ASN A 413
ILE A 422
 BMF  A 501 (-4.2A)
BMF  A 501 ( 4.9A)
BMF  A 501 ( 3.8A)
BMF  A 501 (-2.8A)
BMF  A 501 ( 4.4A)
 0.77A 5y1yA-5u9nA:
14.2		 5y1yA-5u9nA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uiy BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 1A

(Homo sapiens) 		PF00439
(Bromodomain) 		4 VAL A1458
CYH A1505
TYR A1508
ASN A1509
 None
 0.58A 5y1yA-5uiyA:
15.4		 5y1yA-5uiyA:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 4 PRO A 359
VAL A 407
LEU A 265
ILE A  92
 None
 0.90A 5y1yA-5uqrA:
undetectable		 5y1yA-5uqrA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v84 CAT EYE SYNDROME
CRITICAL REGION
PROTEIN 2

(Homo sapiens) 		PF00439
(Bromodomain) 		5 PRO A 458
VAL A 463
CYH A 510
TYR A 513
ASN A 514
 96V  A 602 (-4.5A)
96V  A 602 (-3.9A)
96V  A 602 ( 3.9A)
96V  A 602 ( 4.3A)
96V  A 602 (-2.6A)
 0.43A 5y1yA-5v84A:
16.5		 5y1yA-5v84A:
28.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vbr BROMODOMAIN
TESTIS-SPECIFIC
PROTEIN

(Homo sapiens) 		no annotation 8 PRO A  51
VAL A  56
LEU A  61
LEU A  63
CYH A 105
TYR A 108
ASN A 109
ILE A 115
 IBI  A 201 (-4.3A)
IBI  A 201 ( 4.6A)
IBI  A 201 (-4.2A)
IBI  A 201 (-4.9A)
IBI  A 201 ( 4.0A)
IBI  A 201 ( 4.5A)
IBI  A 201 (-3.3A)
IBI  A 201 ( 3.8A)
 0.56A 5y1yA-5vbrA:
19.2		 5y1yA-5vbrA:
64.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0e CREB-BINDING PROTEIN

(Homo sapiens) 		no annotation 4 PRO A1110
VAL A1115
LEU A1120
TYR A1167
 9U4  A1201 (-3.9A)
9U4  A1201 (-4.6A)
9U4  A1201 ( 4.1A)
None
 0.60A 5y1yA-5w0eA:
17.0		 5y1yA-5w0eA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0e CREB-BINDING PROTEIN

(Homo sapiens) 		no annotation 4 VAL A1115
LEU A1120
TYR A1167
ASN A1168
 9U4  A1201 (-4.6A)
9U4  A1201 ( 4.1A)
None
9U4  A1201 (-3.2A)
 0.40A 5y1yA-5w0eA:
17.0		 5y1yA-5w0eA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1z PROTEIN KINASE
C-BINDING PROTEIN 1

(Homo sapiens) 		no annotation 4 VAL C 177
CYH C 224
TYR C 227
ASN C 228
 None
 0.53A 5y1yA-5y1zC:
10.9		 5y1yA-5y1zC:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cw0 CGD2_2690 PROTEIN

(Cryptosporidium
parvum) 		no annotation 6 VAL A  30
LEU A  35
LEU A  37
CYH A  79
TYR A  82
ASN A  83
 R78  A 201 (-4.5A)
R78  A 201 (-4.9A)
None
R78  A 201 ( 3.8A)
UNX  A 203 ( 4.1A)
R78  A 201 (-3.3A)
 0.35A 5y1yA-6cw0A:
16.9		 5y1yA-6cw0A:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dne BROMODOMAIN-CONTAINI
NG PROTEIN 4

(Homo sapiens) 		no annotation 8 PRO A  82
VAL A  87
LEU A  92
LEU A  94
CYH A 136
TYR A 139
ASN A 140
ILE A 146
 H1V  A 501 (-4.6A)
H1V  A 501 ( 4.4A)
H1V  A 501 (-4.2A)
H1V  A 501 (-4.7A)
H1V  A 501 ( 4.2A)
None
H1V  A 501 (-3.2A)
H1V  A 501 (-3.8A)
 0.46A 5y1yA-6dneA:
23.4		 5y1yA-6dneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fri ALKANAL
MONOOXYGENASE BETA
CHAIN

(Photobacterium
leiognathi) 		no annotation 4 LEU A 105
CYH A 133
TYR A 134
ILE A  80
 None
 0.92A 5y1yA-6friA:
undetectable		 5y1yA-6friA:
19.53