SIMILAR PATTERNS OF AMINO ACIDS FOR 5XXI_A_LSNA503_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1adv ADENOVIRUS
SINGLE-STRANDED
DNA-BINDING PROTEIN

(Human
mastadenovirus
C) 		PF02236
(Viral_DNA_bi)
PF03728
(Viral_DNA_Zn_bi) 		5 LEU A 379
LEU A 232
THR A 233
PRO A 474
LEU A 445
 None
 1.12A 5xxiA-1advA:
0.0		 5xxiA-1advA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 225
PHE A 273
PRO A 245
THR A 244
LEU A 268
 None
 1.20A 5xxiA-1cm8A:
0.0		 5xxiA-1cm8A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dix EXTRACELLULAR
RIBONUCLEASE LE

(Solanum
lycopersicum) 		PF00445
(Ribonuclease_T2) 		5 ILE A 145
GLN A  11
PRO A  14
LEU A 171
PHE A  36
 None
 1.21A 5xxiA-1dixA:
0.0		 5xxiA-1dixA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eav MOLYBDOPTERIN
BIOSYNTHESIS CNX1
PROTEIN

(Arabidopsis
thaliana) 		PF00994
(MoCF_biosynth) 		5 ILE A 162
LEU A  63
LEU A 105
PRO A 102
THR A 101
 None
 1.22A 5xxiA-1eavA:
undetectable		 5xxiA-1eavA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7c RHOGAP PROTEIN

(Gallus gallus) 		PF00620
(RhoGAP) 		5 LEU A 345
PRO A 342
THR A 343
LEU A 265
PHE A 340
 None
 1.20A 5xxiA-1f7cA:
0.5		 5xxiA-1f7cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 ILE A  19
PHE A 113
PHE A 120
THR A  15
PRO A  45
 None
 0.99A 5xxiA-1gjuA:
0.0		 5xxiA-1gjuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 ILE A 452
LEU A 433
PRO A 486
THR A 489
LEU A 449
 None
 1.23A 5xxiA-1gjuA:
0.0		 5xxiA-1gjuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyb RIBONUCLEASE

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		5 ILE A 144
GLN A  11
PRO A  14
LEU A 170
PHE A  36
 None
 1.26A 5xxiA-1iybA:
undetectable		 5xxiA-1iybA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A 313
GLN A  50
PRO A 245
THR A 246
LEU A 311
 None
 1.23A 5xxiA-1knrA:
0.0		 5xxiA-1knrA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 PHE A 114
LEU A 359
PRO A 360
THR A 361
PRO A 364
 DIF  A 501 (-4.5A)
DIF  A 501 (-4.4A)
None
None
None
 0.67A 5xxiA-1nr6A:
55.4		 5xxiA-1nr6A:
76.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ILE A 112
LEU A 229
PRO A  77
LEU A  82
PHE A  74
 None
 1.12A 5xxiA-1pxtA:
undetectable		 5xxiA-1pxtA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q40 MRNA EXPORT FACTOR
MEX67

(Candida
albicans) 		no annotation 5 ILE B 313
PHE B 479
PHE B 337
LEU B 317
PHE B 475
 None
 1.13A 5xxiA-1q40B:
undetectable		 5xxiA-1q40B:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		5 ILE A 629
ASN A 573
LEU A 621
PRO A 622
PRO A 580
 None
 1.12A 5xxiA-1r6vA:
undetectable		 5xxiA-1r6vA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wba WINGED BEAN ALBUMIN
1

(Psophocarpus
tetragonolobus) 		PF00197
(Kunitz_legume) 		5 ILE A  46
PHE A 169
LEU A 133
LEU A 104
PHE A 118
 None
 1.20A 5xxiA-1wbaA:
undetectable		 5xxiA-1wbaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 ILE A 337
PHE A 182
LEU A 181
LEU A  55
LEU A 333
 None
 1.12A 5xxiA-1wy0A:
undetectable		 5xxiA-1wy0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z85 HYPOTHETICAL PROTEIN
TM1380

(Thermotoga
maritima) 		PF04452
(Methyltrans_RNA) 		5 ILE A  91
PHE A 104
LEU A 141
PHE A 107
LEU A 153
 None
 1.27A 5xxiA-1z85A:
undetectable		 5xxiA-1z85A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 ILE A 600
LEU A 640
LEU A 542
THR A 540
PHE A 544
 None
 1.16A 5xxiA-2cfzA:
undetectable		 5xxiA-2cfzA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2r UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF01255
(Prenyltransf) 		5 ASN A 217
LEU A 206
THR A 181
LEU A 179
PHE A 210
 None
 1.29A 5xxiA-2d2rA:
undetectable		 5xxiA-2d2rA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz6 ENDOPLASMIC
RETICULUM TO NUCLEUS
SIGNALLING 1 ISOFORM
1 VARIANT

(Homo sapiens) 		PF13360
(PQQ_2) 		5 ILE A 100
ASN A 176
LEU A  85
PRO A  75
LEU A  82
 None
 1.22A 5xxiA-2hz6A:
undetectable		 5xxiA-2hz6A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3e G-RICH

(Carassius
auratus) 		PF05881
(CNPase) 		5 LEU A 100
LEU A 175
PRO A 147
PRO A 137
LEU A 140
 None
 1.27A 5xxiA-2i3eA:
undetectable		 5xxiA-2i3eA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 PHE A 221
PHE A 264
ASN A 196
LEU A 251
PRO A 215
 None
 1.26A 5xxiA-2i6bA:
undetectable		 5xxiA-2i6bA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7q MCMV TEGUMENT
PROTEIN M48 ENCODED
UBIQUITIN- SPECIFIC
PROTEASE, M48USP

(Murid
betaherpesvirus
1) 		PF04843
(Herpes_teg_N) 		5 ILE A  61
LEU A 213
LEU A  31
THR A  29
LEU A  58
 None
 1.18A 5xxiA-2j7qA:
undetectable		 5xxiA-2j7qA:
17.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens) 		PF00067
(p450) 		5 ILE A  74
ASN A 217
PRO A 363
THR A 364
PRO A 367
 None
None
None
None
225  A 501 ( 4.7A)
 0.54A 5xxiA-2nnjA:
58.3		 5xxiA-2nnjA:
78.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oml RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE E

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 ILE A  67
LEU A 204
ASN A  45
LEU A  98
LEU A  88
 None
 1.29A 5xxiA-2omlA:
undetectable		 5xxiA-2omlA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbp ENOYL-COA HYDRATASE
SUBUNIT I

(Geobacillus
kaustophilus) 		PF00378
(ECH_1) 		5 ILE A  37
LEU A 115
LEU A 105
LEU A  20
PHE A  62
 None
 1.21A 5xxiA-2pbpA:
undetectable		 5xxiA-2pbpA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pk0 SERINE/THREONINE
PROTEIN PHOSPHATASE
STP1

(Streptococcus
agalactiae) 		PF13672
(PP2C_2) 		5 ILE A 203
LEU A   6
GLN A 218
ASN A 217
LEU A 198
 None
 1.28A 5xxiA-2pk0A:
undetectable		 5xxiA-2pk0A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		5 ILE A 166
PHE A  91
LEU A 183
THR A 179
LEU A 175
 None
 1.23A 5xxiA-3cnyA:
undetectable		 5xxiA-3cnyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6k PUTATIVE
AMINOTRANSFERASE

(Corynebacterium
diphtheriae) 		PF12897
(Aminotran_MocR) 		5 ILE A 213
ASN A 217
THR A 197
LEU A 201
PHE A 193
 None
 1.23A 5xxiA-3d6kA:
undetectable		 5xxiA-3d6kA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqv CULLIN-5

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		5 ILE C1686
PHE C1672
ASN C1586
LEU C1634
LEU C1688
 None
 1.03A 5xxiA-3dqvC:
undetectable		 5xxiA-3dqvC:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhl PUTATIVE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 PHE A 308
LEU A  31
THR A   6
LEU A  66
PHE A  29
 None
 1.23A 5xxiA-3fhlA:
undetectable		 5xxiA-3fhlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fot 15-O-ACETYLTRANSFERA
SE

(Fusarium
sporotrichioides) 		PF07428
(Tri3) 		5 ILE A 450
LEU A  82
LEU A 181
THR A  57
LEU A  59
 None
 1.25A 5xxiA-3fotA:
undetectable		 5xxiA-3fotA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h84 ATPASE GET3

(Saccharomyces
cerevisiae) 		PF02374
(ArsA_ATPase) 		5 ILE A 347
PHE A 333
GLN A  41
LEU A 324
LEU A 350
 None
 1.22A 5xxiA-3h84A:
undetectable		 5xxiA-3h84A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs3 RIBOSE OPERON
REPRESSOR

(Lactobacillus
acidophilus) 		PF13377
(Peripla_BP_3) 		5 ILE A 285
PHE A  73
ASN A  71
PRO A 184
THR A 185
 None
 1.28A 5xxiA-3hs3A:
undetectable		 5xxiA-3hs3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		5 ILE A  77
LEU A 117
LEU A  39
PRO A  40
LEU A  45
 None
 1.23A 5xxiA-3iomA:
undetectable		 5xxiA-3iomA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		5 ILE A 178
PHE A 285
ASN A 202
PRO A 304
LEU A 263
 None
 1.06A 5xxiA-3iv7A:
undetectable		 5xxiA-3iv7A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvv TWITCHING MOBILITY
PROTEIN

(Pseudomonas
aeruginosa) 		PF00437
(T2SSE) 		5 ILE A   3
PHE A  96
PHE A  86
LEU A  24
PRO A  25
 None
 1.05A 5xxiA-3jvvA:
undetectable		 5xxiA-3jvvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 ILE A 395
LEU A 313
LEU A 496
PRO A 501
LEU A 398
 None
 1.26A 5xxiA-3k4xA:
undetectable		 5xxiA-3k4xA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		5 ILE A 295
PHE A 348
LEU A 282
LEU A 290
PHE A 368
 None
 1.12A 5xxiA-3ke3A:
undetectable		 5xxiA-3ke3A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kew DHHA1 DOMAIN PROTEIN

(Clostridium
perfringens) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		5 ILE A  11
LEU A  80
LEU A   1
THR A   2
LEU A   4
 None
 0.84A 5xxiA-3kewA:
undetectable		 5xxiA-3kewA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6a EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A 147
GLN A 143
LEU A 136
PRO A 135
LEU A 187
 None
 1.25A 5xxiA-3l6aA:
undetectable		 5xxiA-3l6aA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN

(Thermus
thermophilus) 		PF13458
(Peripla_BP_6) 		5 ILE A 111
LEU A  90
PHE A  79
PRO A 103
LEU A 121
 None
 1.21A 5xxiA-3lkbA:
undetectable		 5xxiA-3lkbA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		5 ILE A 275
PHE A 243
LEU A 333
PRO A 326
LEU A 307
 None
HP8  A 601 (-4.0A)
None
None
None
 1.22A 5xxiA-3o82A:
undetectable		 5xxiA-3o82A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		5 ILE A 241
PHE A 239
LEU A 235
THR A 277
PRO A 260
 None
 1.10A 5xxiA-3okyA:
undetectable		 5xxiA-3okyA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		5 ILE A 171
LEU A  90
PRO A  60
THR A  55
LEU A  52
 None
 1.22A 5xxiA-3p5nA:
undetectable		 5xxiA-3p5nA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		5 LEU A 211
PHE A 130
LEU A  31
PRO A  28
LEU A   9
 None
 1.14A 5xxiA-3pl0A:
undetectable		 5xxiA-3pl0A:
16.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		5 ILE A  94
PHE A 120
PHE A 134
PRO A 396
PRO A 400
 None
None
BHF  A 800 (-4.8A)
None
None
 1.15A 5xxiA-3pm0A:
38.4		 5xxiA-3pm0A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qit POLYKETIDE SYNTHASE

(Moorea
producens) 		PF00561
(Abhydrolase_1) 		5 LEU A 241
ASN A 242
LEU A 105
THR A 107
LEU A 224
 None
 1.25A 5xxiA-3qitA:
undetectable		 5xxiA-3qitA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		5 ILE A  26
LEU A 125
PRO A 163
THR A 164
LEU A 171
 None
 1.26A 5xxiA-3r7wA:
undetectable		 5xxiA-3r7wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsn 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF04166
(PdxA) 		5 ILE A 325
LEU A  86
THR A 130
LEU A 128
PHE A 113
 None
 1.13A 5xxiA-3tsnA:
undetectable		 5xxiA-3tsnA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 ILE A 278
LEU A 680
THR A 684
LEU A 685
PHE A 675
 None
 1.25A 5xxiA-3zgbA:
undetectable		 5xxiA-3zgbA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zth STU0660

(Streptococcus
thermophilus) 		PF16813
(Cas_St_Csn2) 		5 ILE A 201
PHE A 184
LEU A 183
PHE A 172
LEU A 203
 None
 1.12A 5xxiA-3zthA:
undetectable		 5xxiA-3zthA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE

(Streptococcus
pneumoniae) 		PF00596
(Aldolase_II) 		5 ILE A  92
PRO A  42
THR A  41
LEU A  28
PHE A  47
 None
 1.29A 5xxiA-4c25A:
undetectable		 5xxiA-4c25A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fjo DNA POLYMERASE ZETA
CATALYTIC SUBUNIT
MITOTIC SPINDLE
ASSEMBLY CHECKPOINT
PROTEIN MAD2B

(Mus musculus) 		PF02301
(HORMA)
no annotation 		5 ILE C  64
PHE C 146
LEU C  88
LEU D1878
PRO D1881
 None
 1.17A 5xxiA-4fjoC:
undetectable		 5xxiA-4fjoC:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		5 ILE A 197
PHE A 110
LEU A 253
PRO A 250
PRO A 192
 None
 1.08A 5xxiA-4flmA:
undetectable		 5xxiA-4flmA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 ILE A 863
PHE A 909
GLN A 881
LEU A 937
LEU A 901
 None
 1.22A 5xxiA-4fysA:
undetectable		 5xxiA-4fysA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hp4 EAG-LIKE K[+]
CHANNEL

(Drosophila
melanogaster) 		PF13426
(PAS_9) 		5 PHE A  48
ASN A  28
PRO A 105
LEU A  69
PHE A 106
 None
None
None
None
MLY  A 100 ( 4.5A)
 1.17A 5xxiA-4hp4A:
undetectable		 5xxiA-4hp4A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idj FAB HEAVY CHAIN
FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 PHE L  98
LEU L   4
GLN L  90
PRO H 100
THR H 100
 None
 1.24A 5xxiA-4idjL:
undetectable		 5xxiA-4idjL:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		5 ILE A  41
PHE A 376
LEU A 312
PRO A  67
LEU A  57
 None
 1.28A 5xxiA-4iglA:
undetectable		 5xxiA-4iglA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		5 ASN A 119
LEU A 419
THR A 418
LEU A 391
PHE A 415
 None
 1.17A 5xxiA-4js5A:
undetectable		 5xxiA-4js5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4juu EPIMERASE

(Xanthomonas
campestris) 		PF05544
(Pro_racemase) 		5 ILE A 131
LEU A  31
PRO A 115
THR A 114
PHE A  78
 None
 1.15A 5xxiA-4juuA:
undetectable		 5xxiA-4juuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ILE A 314
LEU A 156
PRO A 146
LEU A 148
PHE A 295
 None
 1.22A 5xxiA-4k0rA:
undetectable		 5xxiA-4k0rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 ILE A 232
LEU A 202
GLN A 157
PRO A 274
LEU A 221
 None
 1.23A 5xxiA-4kg7A:
undetectable		 5xxiA-4kg7A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lji CYTOCHROME
C-550-LIKE PROTEIN

(Thermosynechococcus
elongatus) 		PF14495
(Cytochrom_C550) 		5 ILE A 121
LEU A  57
PRO A  58
THR A  56
LEU A  64
 None
None
HEM  A 301 ( 4.4A)
HEM  A 301 (-4.1A)
HEM  A 301 (-4.9A)
 1.27A 5xxiA-4ljiA:
undetectable		 5xxiA-4ljiA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		5 ILE A   6
LEU A  33
LEU A  60
LEU A  20
PHE A  62
 None
 1.28A 5xxiA-4muoA:
undetectable		 5xxiA-4muoA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nef AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		5 ILE A 164
GLN A  93
LEU A 209
PRO A 208
LEU A 141
 None
 1.24A 5xxiA-4nefA:
undetectable		 5xxiA-4nefA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 ILE A 267
LEU A 245
GLN A 241
PRO A 265
PHE A 238
 None
 1.21A 5xxiA-4ojzA:
undetectable		 5xxiA-4ojzA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0k PHYTOHORMONE BINDING
PROTEIN MTPHBP

(Medicago
truncatula) 		PF00407
(Bet_v_1) 		5 ILE A  82
GLN A  68
LEU A  34
PRO A  31
PHE A  56
 None
GOL  A 202 ( 3.1A)
None
None
GA3  A 201 (-3.6A)
 1.18A 5xxiA-4q0kA:
undetectable		 5xxiA-4q0kA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8f VACUOLAR
AMINOPEPTIDASE 1

(Saccharomyces
cerevisiae) 		PF02127
(Peptidase_M18) 		5 ILE A 366
PHE A 453
LEU A 271
LEU A 416
LEU A 427
 None
 1.07A 5xxiA-4r8fA:
undetectable		 5xxiA-4r8fA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		5 ILE A 183
PHE A 131
LEU A  71
PHE A 139
ASN A  72
 None
 1.29A 5xxiA-4r9iA:
undetectable		 5xxiA-4r9iA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgi UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF13619
(KTSC) 		5 ILE A  60
GLN A  44
ASN A  45
PRO A  18
PRO A  39
 None
None
None
None
GOL  A 104 (-4.6A)
 1.27A 5xxiA-4rgiA:
undetectable		 5xxiA-4rgiA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjx HSDR

(Escherichia
coli) 		PF04313
(HSDR_N)
PF04851
(ResIII)
PF12008
(EcoR124_C) 		5 ILE A 137
PHE A 195
LEU A 123
PRO A 160
LEU A 155
 None
 1.12A 5xxiA-4xjxA:
undetectable		 5xxiA-4xjxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc7 FORMIN-LIKE PROTEIN
2

(Homo sapiens) 		PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		5 ILE B 368
LEU B 267
LEU B 347
LEU B 353
PHE B 307
 None
 1.20A 5xxiA-4yc7B:
undetectable		 5xxiA-4yc7B:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 ILE A 279
LEU A 683
THR A 687
LEU A 688
PHE A 678
 None
 1.24A 5xxiA-5fdnA:
undetectable		 5xxiA-5fdnA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE C 475
LEU C 693
GLN C 509
LEU C 444
THR C 514
 MCN  C 921 ( 4.3A)
None
None
None
None
 1.27A 5xxiA-5g5gC:
undetectable		 5xxiA-5g5gC:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gp0 NUDIX HYDROLASE 1

(Arabidopsis
thaliana) 		no annotation 5 ASN E 139
LEU E  23
PRO E  39
LEU E 130
PHE E  15
 None
None
None
GPP  E 202 ( 4.2A)
None
 1.14A 5xxiA-5gp0E:
undetectable		 5xxiA-5gp0E:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		5 ILE A 177
GLN A 108
LEU A 222
PRO A 221
LEU A 153
 None
 1.18A 5xxiA-5i32A:
undetectable		 5xxiA-5i32A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		5 ILE A 356
PHE A 376
LEU A 374
PHE A 368
LEU A 399
 None
 1.24A 5xxiA-5iheA:
undetectable		 5xxiA-5iheA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL

(Coccidioides
posadasii) 		PF00579
(tRNA-synt_1b) 		5 ILE A 264
PHE A 293
LEU A 292
LEU A 302
LEU A 230
 None
 1.22A 5xxiA-5ijxA:
undetectable		 5xxiA-5ijxA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iki CYTOCHROME P450(MEG)

(Bacillus
megaterium) 		PF00067
(p450) 		5 ILE A 127
LEU A 270
LEU A 251
LEU A 142
PHE A 256
 None
None
HEM  A 501 ( 4.2A)
None
None
 1.27A 5xxiA-5ikiA:
29.2		 5xxiA-5ikiA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 LEU A 495
LEU A 528
PRO A 525
THR A 526
LEU A 562
 None
 1.00A 5xxiA-5irmA:
undetectable		 5xxiA-5irmA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		5 LEU A 371
LEU A 212
PRO A 209
THR A 211
LEU A 432
 None
 1.27A 5xxiA-5jy9A:
undetectable		 5xxiA-5jy9A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 ILE A  23
PHE A 106
LEU A 298
THR A 297
LEU A  19
 None
 1.12A 5xxiA-5k1uA:
undetectable		 5xxiA-5k1uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kes DNA DAMAGE-INDUCIBLE
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE A 115
LEU A 137
LEU A 126
PRO A 125
PHE A 128
 None
 1.20A 5xxiA-5kesA:
undetectable		 5xxiA-5kesA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwl VP3

(Enterovirus C) 		PF00073
(Rhv) 		5 ILE 3 190
PHE 3 118
LEU 3 211
LEU 3  57
LEU 3  85
 None
 1.25A 5xxiA-5kwl3:
undetectable		 5xxiA-5kwl3:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lb3 ATP-DEPENDENT DNA
HELICASE Q5

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16124
(RecQ_Zn_bind) 		5 LEU B 154
PRO B 140
THR B 141
LEU B 116
PHE B 138
 None
 1.19A 5xxiA-5lb3B:
undetectable		 5xxiA-5lb3B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj9 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		no annotation 5 ILE A  10
LEU A  75
LEU A   4
PRO A   3
LEU A   7
 None
 1.27A 5xxiA-5lj9A:
undetectable		 5xxiA-5lj9A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 ILE A 502
PHE A 630
LEU A 631
LEU A 563
LEU A 678
 None
 1.12A 5xxiA-5n2gA:
undetectable		 5xxiA-5n2gA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01030
(Recep_L_domain) 		5 ILE M 421
LEU M 371
LEU M 348
PRO M 349
LEU M 419
 None
 1.28A 5xxiA-5sx4M:
undetectable		 5xxiA-5sx4M:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		5 PHE A   7
LEU A 353
THR A 352
LEU A 108
PHE A 325
 None
 1.28A 5xxiA-5uidA:
undetectable		 5xxiA-5uidA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ver KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 3

(Mus musculus) 		no annotation 5 ILE A 233
PHE A 196
PRO A 217
THR A 216
LEU A 214
 None
 1.11A 5xxiA-5verA:
undetectable		 5xxiA-5verA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wai POLYCOMB PROTEIN
SUZ12

(Homo sapiens) 		no annotation 5 PHE B 165
LEU B 355
THR B 222
PRO B 217
LEU B 219
 None
 1.22A 5xxiA-5waiB:
undetectable		 5xxiA-5waiB:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xse KHG/KDPG ALDOLASE

(Zymomonas
mobilis) 		no annotation 5 ILE A   4
LEU A 120
PRO A 155
PRO A 108
LEU A 107
 None
 1.29A 5xxiA-5xseA:
undetectable		 5xxiA-5xseA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxa NON-STRUCTURAL
PROTEIN 1

(Yellow fever
virus) 		no annotation 5 ILE A  42
LEU A  48
THR A  47
LEU A  45
PHE A  29
 None
 1.10A 5xxiA-5yxaA:
undetectable		 5xxiA-5yxaA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7q FLAGELLIN

(Bacillus cereus) 		no annotation 5 ILE A 164
PHE A 204
LEU A 208
THR A 128
LEU A 136
 None
 1.23A 5xxiA-5z7qA:
undetectable		 5xxiA-5z7qA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 5 ILE A1372
LEU A1404
GLN A1474
LEU A1452
PHE A1475
 None
 1.16A 5xxiA-6bhuA:
undetectable		 5xxiA-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f RIBOSOME BIOGENESIS
PROTEIN BRX1

(Saccharomyces
cerevisiae) 		no annotation 5 ILE b 152
PHE b 112
PHE b  89
LEU b  55
LEU b 156
 None
 1.29A 5xxiA-6c0fb:
undetectable		 5xxiA-6c0fb:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 PHE A 100
LEU A  98
LEU A 109
THR A 107
LEU A 145
 None
 1.11A 5xxiA-6e85A:
undetectable		 5xxiA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 6 ILE A 284
LEU A 314
LEU A 246
PRO A 247
THR A 248
LEU A 230
 None
 1.43A 5xxiA-6eojA:
undetectable		 5xxiA-6eojA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ILE A 101
PHE A 136
GLN A 355
LEU A  25
PHE A 126
 None
 1.29A 5xxiA-9rubA:
undetectable		 5xxiA-9rubA:
19.55