SIMILAR PATTERNS OF AMINO ACIDS FOR 5XXI_A_LSNA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE


(Homo sapiens)
PF00351
(Biopterin_H)
4 GLY A 188
THR A 189
LYS A 192
LYS A 195
None
0.95A 5xxiA-1dmwA:
0.0
5xxiA-1dmwA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8j RUBREDOXIN

(Desulfovibrio
gigas)
PF00301
(Rubredoxin)
4 PRO A  26
GLY A  27
THR A  28
LYS A  29
None
1.03A 5xxiA-1e8jA:
undetectable
5xxiA-1e8jA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6n GAG POLYPROTEIN

(Human
immunodeficiency
virus 1)
PF00540
(Gag_p17)
PF00607
(Gag_p24)
4 PRO A 149
THR A 151
ASN A 153
LYS A 157
None
0.99A 5xxiA-1l6nA:
0.6
5xxiA-1l6nA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbu MURAMOYL-PENTAPEPTID
E CARBOXYPEPTIDASE


(Streptomyces
albus)
PF01471
(PG_binding_1)
PF08291
(Peptidase_M15_3)
4 PRO A  67
THR A  69
ASN A  71
LYS A  72
None
0.67A 5xxiA-1lbuA:
undetectable
5xxiA-1lbuA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS


(Thermus
aquaticus)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
4 PRO A 118
GLY A 119
THR A 120
ASN A 132
None
0.86A 5xxiA-1nneA:
0.0
5xxiA-1nneA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)


(Escherichia
coli)
PF01464
(SLT)
PF14718
(SLT_L)
4 PRO A 499
GLY A 500
THR A 501
LYS A 507
SO4  A 709 (-3.8A)
SO4  A 709 (-3.4A)
GOL  A 906 (-2.8A)
None
0.69A 5xxiA-1qsaA:
0.0
5xxiA-1qsaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxy METHIONYL
AMINOPEPTIDASE


(Staphylococcus
aureus)
PF00557
(Peptidase_M24)
4 PRO A 139
GLY A 140
THR A 141
LYS A 142
None
1.00A 5xxiA-1qxyA:
0.0
5xxiA-1qxyA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s8e EXONUCLEASE PUTATIVE

(Pyrococcus
furiosus)
PF00149
(Metallophos)
4 PRO A  58
GLY A  59
THR A  60
LYS A  63
None
0.41A 5xxiA-1s8eA:
undetectable
5xxiA-1s8eA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sie POLYOMAVIRUS COAT
PROTEIN VP1


(Mus musculus
polyomavirus 1)
PF00718
(Polyoma_coat)
4 PRO A  90
GLY A  91
THR A  94
ASN A  92
None
GAL  A 385 ( 4.6A)
None
None
1.05A 5xxiA-1sieA:
0.0
5xxiA-1sieA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t61 TYPE IV COLLAGEN

(Bos taurus)
PF01413
(C4)
4 PRO A  22
GLY A  23
THR A  24
LYS A  25
None
1.12A 5xxiA-1t61A:
undetectable
5xxiA-1t61A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpv UPF0230 PROTEIN
TM1468


(Thermotoga
maritima)
PF02645
(DegV)
4 PRO A 274
GLY A 275
THR A 276
ASN A 239
None
1.12A 5xxiA-1vpvA:
undetectable
5xxiA-1vpvA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B


(Aspergillus
kawachii)
PF05270
(AbfB)
PF09206
(ArabFuran-catal)
4 PRO A 142
GLY A 143
THR A 144
ASN A 300
None
0.84A 5xxiA-1wd3A:
undetectable
5xxiA-1wd3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmr ISOPULLULANASE

(Aspergillus
niger)
PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N)
4 PRO A 359
GLY A 360
THR A 361
ASN A 381
None
None
None
NAG  A1003 (-1.8A)
1.05A 5xxiA-1wmrA:
undetectable
5xxiA-1wmrA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd9 CORE HISTONE
MACRO-H2A.1


(Rattus
norvegicus)
PF01661
(Macro)
4 PRO A  75
GLY A  74
ASN A  73
LYS A  72
None
1.10A 5xxiA-1yd9A:
undetectable
5xxiA-1yd9A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk4 RUBREDOXIN

(Pyrococcus
abyssi)
PF00301
(Rubredoxin)
4 PRO A  26
GLY A  27
THR A  28
LYS A  29
None
0.93A 5xxiA-1yk4A:
undetectable
5xxiA-1yk4A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr5 H2AFY PROTEIN

(Homo sapiens)
PF01661
(Macro)
4 PRO A 252
GLY A 251
ASN A 250
LYS A 249
None
1.04A 5xxiA-1zr5A:
undetectable
5xxiA-1zr5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN


(Homo sapiens)
PF00089
(Trypsin)
4 PRO B 598
GLY B 599
THR B 600
ASN B 625
None
1.01A 5xxiA-2asuB:
undetectable
5xxiA-2asuB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsk MITOCHONDRIAL IMPORT
INNER MEMBRANE
TRANSLOCASE SUBUNIT
TIM9 A


(Homo sapiens)
PF02953
(zf-Tim10_DDP)
4 GLY A  19
THR A  20
ASN A  22
LYS A  23
None
1.13A 5xxiA-2bskA:
undetectable
5xxiA-2bskA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1


(Salmonella
enterica)
no annotation 4 GLY A 485
THR A 488
ASN A 486
LYS A 487
None
0.94A 5xxiA-2d4yA:
undetectable
5xxiA-2d4yA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw1 CATROCOLLASTATIN

(Crotalus atrox)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 587
GLY A 588
THR A 589
LYS A 590
None
0.93A 5xxiA-2dw1A:
undetectable
5xxiA-2dw1A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
4 PRO A 351
GLY A 352
THR A 353
LYS A 354
None
1.11A 5xxiA-2e0pA:
undetectable
5xxiA-2e0pA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN


(Daboia
siamensis)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 399
GLY A 400
THR A 401
LYS A 402
None
1.09A 5xxiA-2e3xA:
undetectable
5xxiA-2e3xA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1


(Crotalus atrox)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 588
GLY A 589
THR A 590
LYS A 591
None
1.09A 5xxiA-2erqA:
undetectable
5xxiA-2erqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ete OXALATE OXIDASE 1

(Hordeum vulgare)
PF00190
(Cupin_1)
4 PRO A  65
GLY A  66
THR A  67
ASN A  68
None
1.04A 5xxiA-2eteA:
undetectable
5xxiA-2eteA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gi4 POSSIBLE
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE


(Campylobacter
jejuni)
PF01451
(LMWPc)
4 GLY A  54
THR A  55
ASN A  57
LYS A  58
None
0.80A 5xxiA-2gi4A:
undetectable
5xxiA-2gi4A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icu HYPOTHETICAL PROTEIN
YEDK


(Escherichia
coli)
PF02586
(SRAP)
4 PRO A  47
GLY A  48
THR A  49
LYS A  50
None
1.12A 5xxiA-2icuA:
undetectable
5xxiA-2icuA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kkd RUBREDOXIN

(Desulfovibrio
vulgaris)
PF00301
(Rubredoxin)
4 PRO A  26
GLY A  27
THR A  28
LYS A   2
None
0.76A 5xxiA-2kkdA:
undetectable
5xxiA-2kkdA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktl TYROSYL-TRNA
SYNTHETASE


(Aspergillus
nidulans)
PF16714
(TyrRSs_C)
4 PRO A 460
GLY A 461
ASN A 462
LYS A 464
None
1.05A 5xxiA-2ktlA:
undetectable
5xxiA-2ktlA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2llf VILLIN-1

(Gallus gallus)
PF00626
(Gelsolin)
4 GLY A  11
THR A  10
ASN A   8
LYS A   9
None
1.01A 5xxiA-2llfA:
undetectable
5xxiA-2llfA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m0o PHD FINGER PROTEIN 1

(Homo sapiens)
no annotation 4 GLY A  34
THR A  50
LYS A  52
LYS A  53
None
1.13A 5xxiA-2m0oA:
undetectable
5xxiA-2m0oA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica)
PF02264
(LamB)
4 PRO A  96
GLY A  97
ASN A  90
LYS A  89
None
0.95A 5xxiA-2mprA:
undetectable
5xxiA-2mprA:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
6 PRO A 227
GLY A 228
THR A 229
ASN A 231
LYS A 232
LYS A 235
None
None
PLM  A 502 (-3.9A)
None
None
None
0.59A 5xxiA-2nnjA:
58.3
5xxiA-2nnjA:
78.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov9 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii)
PF03061
(4HBT)
4 PRO A  94
GLY A  93
THR A  92
ASN A  96
None
1.12A 5xxiA-2ov9A:
undetectable
5xxiA-2ov9A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY


(Streptococcus
pneumoniae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 PRO A 406
GLY A 405
ASN A 200
LYS A 201
None
1.03A 5xxiA-2pokA:
undetectable
5xxiA-2pokA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvx RUBREDOXIN

(Pyrococcus
furiosus)
PF00301
(Rubredoxin)
4 PRO A  26
GLY A  27
THR A  28
LYS A   2
None
0.87A 5xxiA-2pvxA:
undetectable
5xxiA-2pvxA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvx RUBREDOXIN

(Pyrococcus
furiosus)
PF00301
(Rubredoxin)
4 PRO A  26
GLY A  27
THR A  28
LYS A  29
None
1.03A 5xxiA-2pvxA:
undetectable
5xxiA-2pvxA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN


(Arabidopsis
thaliana)
PF01636
(APH)
4 PRO A 325
GLY A 324
ASN A 321
LYS A 322
None
1.09A 5xxiA-2pywA:
undetectable
5xxiA-2pywA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qul D-TAGATOSE
3-EPIMERASE


(Pseudomonas
cichorii)
PF01261
(AP_endonuc_2)
4 GLY A 241
THR A 242
ASN A   2
LYS A   3
None
0.89A 5xxiA-2qulA:
undetectable
5xxiA-2qulA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1k PUTATIVE SORTASE

(Streptococcus
pneumoniae)
PF04203
(Sortase)
4 GLY A 134
THR A 135
ASN A 199
LYS A 198
None
1.05A 5xxiA-2w1kA:
undetectable
5xxiA-2w1kA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xde GAG POLYPROTEIN

(Human
immunodeficiency
virus 1)
PF00607
(Gag_p24)
4 PRO A  17
THR A  19
ASN A  21
LYS A  25
None
0.63A 5xxiA-2xdeA:
undetectable
5xxiA-2xdeA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa)
PF12891
(Glyco_hydro_44)
4 PRO A 350
GLY A 351
THR A 352
LYS A 353
None
1.10A 5xxiA-2yjqA:
undetectable
5xxiA-2yjqA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ylk CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Ruminiclostridium
thermocellum)
PF00942
(CBM_3)
4 PRO A  88
GLY A  91
ASN A  26
LYS A   3
None
1.13A 5xxiA-2ylkA:
undetectable
5xxiA-2ylkA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa)
PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C)
4 PRO A 387
GLY A 381
THR A 380
ASN A 382
None
1.00A 5xxiA-2zwsA:
undetectable
5xxiA-2zwsA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE


(Porphyromonas
gingivalis)
PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C)
4 PRO A  24
GLY A  25
THR A  26
ASN A  53
None
0.94A 5xxiA-3d3uA:
undetectable
5xxiA-3d3uA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN


(Bothrops
jararaca)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 399
GLY A 400
THR A 401
LYS A 402
None
0.99A 5xxiA-3dslA:
undetectable
5xxiA-3dslA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebt UNCHARACTERIZED
NTF2-LIKE PROTEIN


(Burkholderia
pseudomallei)
PF12680
(SnoaL_2)
4 PRO A  72
GLY A  86
THR A  87
LYS A 101
None
1.05A 5xxiA-3ebtA:
undetectable
5xxiA-3ebtA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbz PUTATIVE
UNCHARACTERIZED
PROTEIN


(Acidianus
filamentous
virus 1)
no annotation 4 PRO A  98
THR A 100
ASN A 102
LYS A 106
None
0.91A 5xxiA-3fbzA:
undetectable
5xxiA-3fbzA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 PRO A 218
GLY A 219
THR A 220
LYS A 227
U  C   4 ( 4.2A)
U  C   5 ( 3.1A)
U  C   5 ( 3.5A)
U  C   6 ( 2.9A)
0.85A 5xxiA-3fhtA:
undetectable
5xxiA-3fhtA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frk QDTB

(Thermoanaerobacterium
thermosaccharolyticum)
PF01041
(DegT_DnrJ_EryC1)
4 PRO A 331
GLY A 328
THR A 327
ASN A 329
None
1.06A 5xxiA-3frkA:
undetectable
5xxiA-3frkA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3


(Homo sapiens)
PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase)
4 PRO A 603
GLY A 602
ASN A 599
LYS A 600
None
0.88A 5xxiA-3gvpA:
undetectable
5xxiA-3gvpA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE


(Streptomyces
antibioticus)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 PRO A 448
GLY A 449
THR A 450
LYS A 451
None
1.09A 5xxiA-3gyrA:
undetectable
5xxiA-3gyrA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h75 PERIPLASMIC
SUGAR-BINDING DOMAIN
PROTEIN


(Pseudomonas
protegens)
PF13407
(Peripla_BP_4)
4 PRO A 267
GLY A 268
THR A 269
LYS A 172
None
0.96A 5xxiA-3h75A:
undetectable
5xxiA-3h75A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdb AAHIV

(Deinagkistrodon
acutus)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 587
GLY A 588
THR A 589
LYS A 590
None
1.09A 5xxiA-3hdbA:
undetectable
5xxiA-3hdbA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i23 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Enterococcus
faecalis)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 GLY A 315
THR A 311
ASN A 314
LYS A 313
None
1.02A 5xxiA-3i23A:
undetectable
5xxiA-3i23A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum)
PF12891
(Glyco_hydro_44)
4 PRO A 344
GLY A 345
THR A 346
LYS A 347
None
1.03A 5xxiA-3ik2A:
undetectable
5xxiA-3ik2A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jcu OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC


(Spinacia
oleracea)
PF01716
(MSP)
4 PRO O 175
GLY O 174
THR O 130
LYS O 132
None
1.03A 5xxiA-3jcuO:
undetectable
5xxiA-3jcuO:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k70 EXODEOXYRIBONUCLEASE
V BETA CHAIN


(Escherichia
coli)
PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C)
4 PRO B 451
GLY B 452
ASN B 455
LYS B 459
None
0.74A 5xxiA-3k70B:
undetectable
5xxiA-3k70B:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7l ATRAGIN

(Naja atra)
PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 591
GLY A 592
THR A 593
LYS A 594
None
0.93A 5xxiA-3k7lA:
undetectable
5xxiA-3k7lA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra)
PF01421
(Reprolysin)
PF08516
(ADAM_CR)
4 PRO A 571
GLY A 572
THR A 573
LYS A 574
NAG  A 901 ( 4.9A)
None
None
None
1.05A 5xxiA-3k7nA:
undetectable
5xxiA-3k7nA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN


(Namalycastis
sp. ST01)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
4 GLY A  85
THR A  84
ASN A  39
LYS A  83
None
0.67A 5xxiA-3l2eA:
undetectable
5xxiA-3l2eA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans)
PF00501
(AMP-binding)
4 PRO A  82
GLY A  37
THR A  36
LYS A  34
None
1.04A 5xxiA-3l2kA:
undetectable
5xxiA-3l2kA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29


(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified)
PF07039
(DUF1325)
PF13416
(SBP_bac_8)
4 PRO A1197
GLY A1198
THR A1199
LYS A1200
None
1.05A 5xxiA-3mp6A:
undetectable
5xxiA-3mp6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msx RHO
GTPASE-ACTIVATING
PROTEIN 20


(Homo sapiens)
PF00620
(RhoGAP)
4 PRO B 392
THR B 394
ASN B 502
LYS B 395
None
0.93A 5xxiA-3msxB:
undetectable
5xxiA-3msxB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz1 STEROID
21-HYDROXYLASE


(Bos taurus)
PF00067
(p450)
4 PRO A  58
GLY A  57
THR A  53
LYS A  55
None
1.13A 5xxiA-3qz1A:
40.4
5xxiA-3qz1A:
29.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc3 ATP-DEPENDENT RNA
HELICASE SUPV3L1,
MITOCHONDRIAL


(Homo sapiens)
PF00271
(Helicase_C)
PF12513
(SUV3_C)
4 PRO A 401
GLY A 402
THR A 403
LYS A 409
None
0.41A 5xxiA-3rc3A:
undetectable
5xxiA-3rc3A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
4 PRO A 310
GLY A 311
THR A 312
LYS A 313
None
1.09A 5xxiA-3stjA:
undetectable
5xxiA-3stjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tej ENTEROBACTIN
SYNTHASE COMPONENT F


(Escherichia
coli)
PF00550
(PP-binding)
PF00975
(Thioesterase)
4 PRO A1277
GLY A1278
THR A1279
LYS A1282
None
0.92A 5xxiA-3tejA:
undetectable
5xxiA-3tejA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm8 PROBABLE DNA
DC->DU-EDITING
ENZYME APOBEC-3C


(Homo sapiens)
PF08210
(APOBEC_N)
4 PRO A  14
GLY A  15
THR A  16
LYS A  22
None
1.10A 5xxiA-3vm8A:
undetectable
5xxiA-3vm8A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmr PROLINE
IMINOPEPTIDASE


(Streptomyces
halstedii)
PF00561
(Abhydrolase_1)
4 PRO A 217
GLY A 216
THR A 212
ASN A 215
None
0.66A 5xxiA-3wmrA:
undetectable
5xxiA-3wmrA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqb OPEN READING FRAME 2

(Aeromonas
sobria)
no annotation 4 PRO B 100
GLY B 101
THR B 102
LYS B  44
None
1.05A 5xxiA-3wqbB:
undetectable
5xxiA-3wqbB:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ar6 RUBREDOXIN

(Pyrococcus
furiosus)
PF00301
(Rubredoxin)
4 PRO A  25
GLY A  26
THR A  27
LYS A  28
None
1.07A 5xxiA-4ar6A:
undetectable
5xxiA-4ar6A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE


(Oceanicola
granulosus)
PF00294
(PfkB)
4 PRO A 226
GLY A 225
ASN A 224
LYS A 223
None
0.95A 5xxiA-4e69A:
undetectable
5xxiA-4e69A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esa HEMOGLOBIN BETA
CHAIN


(Eleginops
maclovinus)
PF00042
(Globin)
4 PRO B 124
GLY B 125
THR B 126
LYS B 132
None
0.43A 5xxiA-4esaB:
undetectable
5xxiA-4esaB:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
4 PRO A  56
GLY A  57
THR A  58
ASN A  82
None
1.10A 5xxiA-4gekA:
undetectable
5xxiA-4gekA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gek TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
4 PRO A  56
GLY A  57
THR A  58
LYS A  84
None
1.06A 5xxiA-4gekA:
undetectable
5xxiA-4gekA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN


(Haemophilus
influenzae)
PF05860
(Haemagg_act)
4 GLY A 209
THR A 235
ASN A 241
LYS A 236
None
1.11A 5xxiA-4i84A:
undetectable
5xxiA-4i84A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
4 PRO A  56
GLY A  57
THR A  58
ASN A  82
None
1.08A 5xxiA-4iwnA:
undetectable
5xxiA-4iwnA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwn TRNA
(CMO5U34)-METHYLTRAN
SFERASE


(Escherichia
coli)
PF13649
(Methyltransf_25)
4 PRO A  56
GLY A  57
THR A  58
LYS A  84
None
1.08A 5xxiA-4iwnA:
undetectable
5xxiA-4iwnA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0q ELONGATION FACTOR
TU-A


(Pseudomonas
putida)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
4 GLY A  95
THR A  94
ASN A  91
LYS A  90
None
1.05A 5xxiA-4j0qA:
undetectable
5xxiA-4j0qA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE


(Drosophila
melanogaster)
PF01144
(CoA_trans)
4 PRO A 429
GLY A 430
THR A 431
LYS A 432
None
1.04A 5xxiA-4kgbA:
undetectable
5xxiA-4kgbA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l05 SUPEROXIDE DISMUTASE
[CU-ZN]


(Brucella
abortus)
PF00080
(Sod_Cu)
4 PRO A  76
GLY A  77
THR A  79
ASN A  78
SO4  A 204 (-4.3A)
None
None
None
0.91A 5xxiA-4l05A:
undetectable
5xxiA-4l05A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxw TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 3


(Homo sapiens)
no annotation 4 PRO S  64
GLY S  65
THR S  66
ASN S  89
None
1.09A 5xxiA-4mxwS:
undetectable
5xxiA-4mxwS:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4u PUTATIVE ABC
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN


(Bordetella
bronchiseptica)
PF03480
(DctP)
4 PRO A 259
GLY A 260
THR A 261
LYS A 267
None
0.55A 5xxiA-4n4uA:
undetectable
5xxiA-4n4uA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy2 TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 1


(Saccharomyces
cerevisiae)
PF12157
(DUF3591)
4 PRO A 504
GLY A 505
THR A 506
LYS A 507
None
0.98A 5xxiA-4oy2A:
undetectable
5xxiA-4oy2A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica)
PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C)
4 GLY A 214
THR A 215
ASN A 197
LYS A 355
None
1.02A 5xxiA-4r4zA:
undetectable
5xxiA-4r4zA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud1 N PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus)
PF00937
(Corona_nucleoca)
4 PRO A 152
GLY A 153
THR A 154
LYS A 155
None
0.97A 5xxiA-4ud1A:
undetectable
5xxiA-4ud1A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)


(Clostridium
acetobutylicum)
PF02055
(Glyco_hydro_30)
4 PRO A 238
GLY A 239
THR A 240
LYS A 246
None
0.86A 5xxiA-5cxpA:
undetectable
5xxiA-5cxpA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dhz ANTI-REV ANTIBODY
FAB SINGLE-CHAIN
VARIABLE FRAGMENT,
HEAVY CHAIN


(Oryctolagus
cuniculus)
PF07686
(V-set)
4 PRO H  14
GLY H  15
THR H  16
LYS H  80
None
1.13A 5xxiA-5dhzH:
undetectable
5xxiA-5dhzH:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmg RB86 ANTIBODY FAB
FRAGMENT HEAVY CHAIN


(Oryctolagus
cuniculus)
no annotation 4 PRO H 114
GLY H 115
THR H 116
LYS H 316
None
1.03A 5xxiA-5dmgH:
undetectable
5xxiA-5dmgH:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER


(Pseudomonas
putida)
PF01547
(SBP_bac_1)
4 PRO A  27
GLY A  28
THR A  29
ASN A 314
None
1.11A 5xxiA-5dvjA:
undetectable
5xxiA-5dvjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT BETA


(Pyrococcus
furiosus)
PF10418
(DHODB_Fe-S_bind)
4 GLY S 105
THR S 106
ASN S 131
LYS S 127
None
1.10A 5xxiA-5jfcS:
undetectable
5xxiA-5jfcS:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II


(Streptomyces
sp. SirexAA-E)
PF02012
(BNR)
4 PRO A 486
GLY A 487
THR A 488
ASN A 507
None
0.80A 5xxiA-5jwzA:
undetectable
5xxiA-5jwzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4g L-ASPARAGINASE

(Wolinella
succinogenes)
PF00710
(Asparaginase)
4 PRO A 255
THR A 257
ASN A 259
LYS A 263
None
1.14A 5xxiA-5k4gA:
undetectable
5xxiA-5k4gA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII


(Homo sapiens)
PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3)
4 PRO A 505
GLY A 506
ASN A 467
LYS A 466
None
1.00A 5xxiA-5k8dA:
undetectable
5xxiA-5k8dA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mji BRAMP DOMAIN PROTEIN

(Streptomyces
davaonensis)
PF03358
(FMN_red)
4 PRO A 172
GLY A 171
THR A 170
ASN A 134
None
None
None
7O6  A 301 (-3.4A)
1.07A 5xxiA-5mjiA:
undetectable
5xxiA-5mjiA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr HETERODISULFIDE
REDUCTASE, SUBUNIT A


(Methanothermococcus
thermolithotrophicus)
PF07992
(Pyr_redox_2)
PF13187
(Fer4_9)
4 PRO A 190
THR A 188
ASN A 192
LYS A 187
None
FAD  A 701 (-4.6A)
None
None
1.11A 5xxiA-5odrA:
undetectable
5xxiA-5odrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7


(Homo sapiens)
PF00098
(zf-CCHC)
PF03828
(PAP_assoc)
4 PRO A1038
GLY A1039
THR A1040
LYS A1041
None
1.02A 5xxiA-5w0mA:
undetectable
5xxiA-5w0mA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wls POLLEN RECEPTOR-LIKE
KINASE 3


(Arabidopsis
thaliana)
no annotation 4 PRO A 114
GLY A 115
LYS A 117
LYS A 142
None
1.04A 5xxiA-5wlsA:
undetectable
5xxiA-5wlsA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae)
no annotation 4 PRO A 533
GLY A 534
ASN A 537
LYS A 541
None
0.90A 5xxiA-6fikA:
undetectable
5xxiA-6fikA:
8.84