SIMILAR PATTERNS OF AMINO ACIDS FOR 5XXI_A_LSNA502_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dmw | PHENYLALANINEHYDROXYLASE (Homo sapiens) |
PF00351(Biopterin_H) | 4 | GLY A 188THR A 189LYS A 192LYS A 195 | None | 0.95A | 5xxiA-1dmwA:0.0 | 5xxiA-1dmwA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e8j | RUBREDOXIN (Desulfovibriogigas) |
PF00301(Rubredoxin) | 4 | PRO A 26GLY A 27THR A 28LYS A 29 | None | 1.03A | 5xxiA-1e8jA:undetectable | 5xxiA-1e8jA:7.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l6n | GAG POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00540(Gag_p17)PF00607(Gag_p24) | 4 | PRO A 149THR A 151ASN A 153LYS A 157 | None | 0.99A | 5xxiA-1l6nA:0.6 | 5xxiA-1l6nA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lbu | MURAMOYL-PENTAPEPTIDE CARBOXYPEPTIDASE (Streptomycesalbus) |
PF01471(PG_binding_1)PF08291(Peptidase_M15_3) | 4 | PRO A 67THR A 69ASN A 71LYS A 72 | None | 0.67A | 5xxiA-1lbuA:undetectable | 5xxiA-1lbuA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nne | DNA MISMATCH REPAIRPROTEIN MUTS (Thermusaquaticus) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05190(MutS_IV)PF05192(MutS_III) | 4 | PRO A 118GLY A 119THR A 120ASN A 132 | None | 0.86A | 5xxiA-1nneA:0.0 | 5xxiA-1nneA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qsa | PROTEIN (SOLUBLELYTICTRANSGLYCOSYLASESLT70) (Escherichiacoli) |
PF01464(SLT)PF14718(SLT_L) | 4 | PRO A 499GLY A 500THR A 501LYS A 507 | SO4 A 709 (-3.8A)SO4 A 709 (-3.4A)GOL A 906 (-2.8A)None | 0.69A | 5xxiA-1qsaA:0.0 | 5xxiA-1qsaA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qxy | METHIONYLAMINOPEPTIDASE (Staphylococcusaureus) |
PF00557(Peptidase_M24) | 4 | PRO A 139GLY A 140THR A 141LYS A 142 | None | 1.00A | 5xxiA-1qxyA:0.0 | 5xxiA-1qxyA:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s8e | EXONUCLEASE PUTATIVE (Pyrococcusfuriosus) |
PF00149(Metallophos) | 4 | PRO A 58GLY A 59THR A 60LYS A 63 | None | 0.41A | 5xxiA-1s8eA:undetectable | 5xxiA-1s8eA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sie | POLYOMAVIRUS COATPROTEIN VP1 (Mus musculuspolyomavirus 1) |
PF00718(Polyoma_coat) | 4 | PRO A 90GLY A 91THR A 94ASN A 92 | NoneGAL A 385 ( 4.6A)NoneNone | 1.05A | 5xxiA-1sieA:0.0 | 5xxiA-1sieA:22.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t61 | TYPE IV COLLAGEN (Bos taurus) |
PF01413(C4) | 4 | PRO A 22GLY A 23THR A 24LYS A 25 | None | 1.12A | 5xxiA-1t61A:undetectable | 5xxiA-1t61A:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpv | UPF0230 PROTEINTM1468 (Thermotogamaritima) |
PF02645(DegV) | 4 | PRO A 274GLY A 275THR A 276ASN A 239 | None | 1.12A | 5xxiA-1vpvA:undetectable | 5xxiA-1vpvA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wd3 | ALPHA-L-ARABINOFURANOSIDASE B (Aspergilluskawachii) |
PF05270(AbfB)PF09206(ArabFuran-catal) | 4 | PRO A 142GLY A 143THR A 144ASN A 300 | None | 0.84A | 5xxiA-1wd3A:undetectable | 5xxiA-1wd3A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wmr | ISOPULLULANASE (Aspergillusniger) |
PF03718(Glyco_hydro_49)PF17433(Glyco_hydro_49N) | 4 | PRO A 359GLY A 360THR A 361ASN A 381 | NoneNoneNoneNAG A1003 (-1.8A) | 1.05A | 5xxiA-1wmrA:undetectable | 5xxiA-1wmrA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yd9 | CORE HISTONEMACRO-H2A.1 (Rattusnorvegicus) |
PF01661(Macro) | 4 | PRO A 75GLY A 74ASN A 73LYS A 72 | None | 1.10A | 5xxiA-1yd9A:undetectable | 5xxiA-1yd9A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yk4 | RUBREDOXIN (Pyrococcusabyssi) |
PF00301(Rubredoxin) | 4 | PRO A 26GLY A 27THR A 28LYS A 29 | None | 0.93A | 5xxiA-1yk4A:undetectable | 5xxiA-1yk4A:9.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zr5 | H2AFY PROTEIN (Homo sapiens) |
PF01661(Macro) | 4 | PRO A 252GLY A 251ASN A 250LYS A 249 | None | 1.04A | 5xxiA-1zr5A:undetectable | 5xxiA-1zr5A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2asu | HEPATOCYTE GROWTHFACTOR-LIKE PROTEIN (Homo sapiens) |
PF00089(Trypsin) | 4 | PRO B 598GLY B 599THR B 600ASN B 625 | None | 1.01A | 5xxiA-2asuB:undetectable | 5xxiA-2asuB:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bsk | MITOCHONDRIAL IMPORTINNER MEMBRANETRANSLOCASE SUBUNITTIM9 A (Homo sapiens) |
PF02953(zf-Tim10_DDP) | 4 | GLY A 19THR A 20ASN A 22LYS A 23 | None | 1.13A | 5xxiA-2bskA:undetectable | 5xxiA-2bskA:10.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d4y | FLAGELLARHOOK-ASSOCIATEDPROTEIN 1 (Salmonellaenterica) |
no annotation | 4 | GLY A 485THR A 488ASN A 486LYS A 487 | None | 0.94A | 5xxiA-2d4yA:undetectable | 5xxiA-2d4yA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw1 | CATROCOLLASTATIN (Crotalus atrox) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 587GLY A 588THR A 589LYS A 590 | None | 0.93A | 5xxiA-2dw1A:undetectable | 5xxiA-2dw1A:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0p | ENDOGLUCANASE (Ruminiclostridiumthermocellum) |
PF12891(Glyco_hydro_44) | 4 | PRO A 351GLY A 352THR A 353LYS A 354 | None | 1.11A | 5xxiA-2e0pA:undetectable | 5xxiA-2e0pA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3x | COAGULATION FACTORX-ACTIVATING ENZYMEHEAVY CHAIN (Daboiasiamensis) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 399GLY A 400THR A 401LYS A 402 | None | 1.09A | 5xxiA-2e3xA:undetectable | 5xxiA-2e3xA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2erq | VASCULARAPOPTOSIS-INDUCINGPROTEIN 1 (Crotalus atrox) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 588GLY A 589THR A 590LYS A 591 | None | 1.09A | 5xxiA-2erqA:undetectable | 5xxiA-2erqA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ete | OXALATE OXIDASE 1 (Hordeum vulgare) |
PF00190(Cupin_1) | 4 | PRO A 65GLY A 66THR A 67ASN A 68 | None | 1.04A | 5xxiA-2eteA:undetectable | 5xxiA-2eteA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gi4 | POSSIBLEPHOSPHOTYROSINEPROTEIN PHOSPHATASE (Campylobacterjejuni) |
PF01451(LMWPc) | 4 | GLY A 54THR A 55ASN A 57LYS A 58 | None | 0.80A | 5xxiA-2gi4A:undetectable | 5xxiA-2gi4A:16.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2icu | HYPOTHETICAL PROTEINYEDK (Escherichiacoli) |
PF02586(SRAP) | 4 | PRO A 47GLY A 48THR A 49LYS A 50 | None | 1.12A | 5xxiA-2icuA:undetectable | 5xxiA-2icuA:16.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kkd | RUBREDOXIN (Desulfovibriovulgaris) |
PF00301(Rubredoxin) | 4 | PRO A 26GLY A 27THR A 28LYS A 2 | None | 0.76A | 5xxiA-2kkdA:undetectable | 5xxiA-2kkdA:9.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ktl | TYROSYL-TRNASYNTHETASE (Aspergillusnidulans) |
PF16714(TyrRSs_C) | 4 | PRO A 460GLY A 461ASN A 462LYS A 464 | None | 1.05A | 5xxiA-2ktlA:undetectable | 5xxiA-2ktlA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2llf | VILLIN-1 (Gallus gallus) |
PF00626(Gelsolin) | 4 | GLY A 11THR A 10ASN A 8LYS A 9 | None | 1.01A | 5xxiA-2llfA:undetectable | 5xxiA-2llfA:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m0o | PHD FINGER PROTEIN 1 (Homo sapiens) |
no annotation | 4 | GLY A 34THR A 50LYS A 52LYS A 53 | None | 1.13A | 5xxiA-2m0oA:undetectable | 5xxiA-2m0oA:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mpr | MALTOPORIN (Salmonellaenterica) |
PF02264(LamB) | 4 | PRO A 96GLY A 97ASN A 90LYS A 89 | None | 0.95A | 5xxiA-2mprA:undetectable | 5xxiA-2mprA:18.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nnj | CYTOCHROME P450 2C8 (Homo sapiens) |
PF00067(p450) | 6 | PRO A 227GLY A 228THR A 229ASN A 231LYS A 232LYS A 235 | NoneNonePLM A 502 (-3.9A)NoneNoneNone | 0.59A | 5xxiA-2nnjA:58.3 | 5xxiA-2nnjA:78.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ov9 | HYPOTHETICAL PROTEIN (Rhodococcusjostii) |
PF03061(4HBT) | 4 | PRO A 94GLY A 93THR A 92ASN A 96 | None | 1.12A | 5xxiA-2ov9A:undetectable | 5xxiA-2ov9A:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pok | PEPTIDASE,M20/M25/M40 FAMILY (Streptococcuspneumoniae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | PRO A 406GLY A 405ASN A 200LYS A 201 | None | 1.03A | 5xxiA-2pokA:undetectable | 5xxiA-2pokA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pvx | RUBREDOXIN (Pyrococcusfuriosus) |
PF00301(Rubredoxin) | 4 | PRO A 26GLY A 27THR A 28LYS A 2 | None | 0.87A | 5xxiA-2pvxA:undetectable | 5xxiA-2pvxA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pvx | RUBREDOXIN (Pyrococcusfuriosus) |
PF00301(Rubredoxin) | 4 | PRO A 26GLY A 27THR A 28LYS A 29 | None | 1.03A | 5xxiA-2pvxA:undetectable | 5xxiA-2pvxA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyw | UNCHARACTERIZEDPROTEIN (Arabidopsisthaliana) |
PF01636(APH) | 4 | PRO A 325GLY A 324ASN A 321LYS A 322 | None | 1.09A | 5xxiA-2pywA:undetectable | 5xxiA-2pywA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qul | D-TAGATOSE3-EPIMERASE (Pseudomonascichorii) |
PF01261(AP_endonuc_2) | 4 | GLY A 241THR A 242ASN A 2LYS A 3 | None | 0.89A | 5xxiA-2qulA:undetectable | 5xxiA-2qulA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1k | PUTATIVE SORTASE (Streptococcuspneumoniae) |
PF04203(Sortase) | 4 | GLY A 134THR A 135ASN A 199LYS A 198 | None | 1.05A | 5xxiA-2w1kA:undetectable | 5xxiA-2w1kA:20.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xde | GAG POLYPROTEIN (Humanimmunodeficiencyvirus 1) |
PF00607(Gag_p24) | 4 | PRO A 17THR A 19ASN A 21LYS A 25 | None | 0.63A | 5xxiA-2xdeA:undetectable | 5xxiA-2xdeA:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yjq | CEL44C (Paenibacilluspolymyxa) |
PF12891(Glyco_hydro_44) | 4 | PRO A 350GLY A 351THR A 352LYS A 353 | None | 1.10A | 5xxiA-2yjqA:undetectable | 5xxiA-2yjqA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylk | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Ruminiclostridiumthermocellum) |
PF00942(CBM_3) | 4 | PRO A 88GLY A 91ASN A 26LYS A 3 | None | 1.13A | 5xxiA-2ylkA:undetectable | 5xxiA-2ylkA:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zws | NEUTRAL CERAMIDASE (Pseudomonasaeruginosa) |
PF04734(Ceramidase_alk)PF17048(Ceramidse_alk_C) | 4 | PRO A 387GLY A 381THR A 380ASN A 382 | None | 1.00A | 5xxiA-2zwsA:undetectable | 5xxiA-2zwsA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d3u | 4-HYDROXYBUTYRATECOA-TRANSFERASE (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 4 | PRO A 24GLY A 25THR A 26ASN A 53 | None | 0.94A | 5xxiA-3d3uA:undetectable | 5xxiA-3d3uA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dsl | ZINCMETALLOPROTEINASE-DISINTEGRINBOTHROPASIN (Bothropsjararaca) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 399GLY A 400THR A 401LYS A 402 | None | 0.99A | 5xxiA-3dslA:undetectable | 5xxiA-3dslA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ebt | UNCHARACTERIZEDNTF2-LIKE PROTEIN (Burkholderiapseudomallei) |
PF12680(SnoaL_2) | 4 | PRO A 72GLY A 86THR A 87LYS A 101 | None | 1.05A | 5xxiA-3ebtA:undetectable | 5xxiA-3ebtA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fbz | PUTATIVEUNCHARACTERIZEDPROTEIN (Acidianusfilamentousvirus 1) |
no annotation | 4 | PRO A 98THR A 100ASN A 102LYS A 106 | None | 0.91A | 5xxiA-3fbzA:undetectable | 5xxiA-3fbzA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fht | ATP-DEPENDENT RNAHELICASE DDX19B (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 4 | PRO A 218GLY A 219THR A 220LYS A 227 | U C 4 ( 4.2A) U C 5 ( 3.1A) U C 5 ( 3.5A) U C 6 ( 2.9A) | 0.85A | 5xxiA-3fhtA:undetectable | 5xxiA-3fhtA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3frk | QDTB (Thermoanaerobacteriumthermosaccharolyticum) |
PF01041(DegT_DnrJ_EryC1) | 4 | PRO A 331GLY A 328THR A 327ASN A 329 | None | 1.06A | 5xxiA-3frkA:undetectable | 5xxiA-3frkA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gvp | ADENOSYLHOMOCYSTEINASE 3 (Homo sapiens) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 4 | PRO A 603GLY A 602ASN A 599LYS A 600 | None | 0.88A | 5xxiA-3gvpA:undetectable | 5xxiA-3gvpA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyr | PHENOXAZINONESYNTHASE (Streptomycesantibioticus) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 4 | PRO A 448GLY A 449THR A 450LYS A 451 | None | 1.09A | 5xxiA-3gyrA:undetectable | 5xxiA-3gyrA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h75 | PERIPLASMICSUGAR-BINDING DOMAINPROTEIN (Pseudomonasprotegens) |
PF13407(Peripla_BP_4) | 4 | PRO A 267GLY A 268THR A 269LYS A 172 | None | 0.96A | 5xxiA-3h75A:undetectable | 5xxiA-3h75A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hdb | AAHIV (Deinagkistrodonacutus) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 587GLY A 588THR A 589LYS A 590 | None | 1.09A | 5xxiA-3hdbA:undetectable | 5xxiA-3hdbA:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i23 | OXIDOREDUCTASE,GFO/IDH/MOCA FAMILY (Enterococcusfaecalis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 4 | GLY A 315THR A 311ASN A 314LYS A 313 | None | 1.02A | 5xxiA-3i23A:undetectable | 5xxiA-3i23A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ik2 | ENDOGLUCANASE A (Clostridiumacetobutylicum) |
PF12891(Glyco_hydro_44) | 4 | PRO A 344GLY A 345THR A 346LYS A 347 | None | 1.03A | 5xxiA-3ik2A:undetectable | 5xxiA-3ik2A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jcu | OXYGEN-EVOLVINGENHANCER PROTEIN 1,CHLOROPLASTIC (Spinaciaoleracea) |
PF01716(MSP) | 4 | PRO O 175GLY O 174THR O 130LYS O 132 | None | 1.03A | 5xxiA-3jcuO:undetectable | 5xxiA-3jcuO:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k70 | EXODEOXYRIBONUCLEASEV BETA CHAIN (Escherichiacoli) |
PF00580(UvrD-helicase)PF12705(PDDEXK_1)PF13361(UvrD_C) | 4 | PRO B 451GLY B 452ASN B 455LYS B 459 | None | 0.74A | 5xxiA-3k70B:undetectable | 5xxiA-3k70B:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7l | ATRAGIN (Naja atra) |
PF00200(Disintegrin)PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 591GLY A 592THR A 593LYS A 594 | None | 0.93A | 5xxiA-3k7lA:undetectable | 5xxiA-3k7lA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k7n | K-LIKE (Naja atra) |
PF01421(Reprolysin)PF08516(ADAM_CR) | 4 | PRO A 571GLY A 572THR A 573LYS A 574 | NAG A 901 ( 4.9A)NoneNoneNone | 1.05A | 5xxiA-3k7nA:undetectable | 5xxiA-3k7nA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2e | GLYCOCYAMINE KINASEALPHA CHAIN (Namalycastissp. ST01) |
PF00217(ATP-gua_Ptrans)PF02807(ATP-gua_PtransN) | 4 | GLY A 85THR A 84ASN A 39LYS A 83 | None | 0.67A | 5xxiA-3l2eA:undetectable | 5xxiA-3l2eA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l2k | EHPF (Pantoeaagglomerans) |
PF00501(AMP-binding) | 4 | PRO A 82GLY A 37THR A 36LYS A 34 | None | 1.04A | 5xxiA-3l2kA:undetectable | 5xxiA-3l2kA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mp6 | MALTOSE-BINDINGPERIPLASMICPROTEIN,LINKER,SAGA-ASSOCIATED FACTOR 29 (Escherichiacoli;Saccharomycescerevisiae;unidentified) |
PF07039(DUF1325)PF13416(SBP_bac_8) | 4 | PRO A1197GLY A1198THR A1199LYS A1200 | None | 1.05A | 5xxiA-3mp6A:undetectable | 5xxiA-3mp6A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3msx | RHOGTPASE-ACTIVATINGPROTEIN 20 (Homo sapiens) |
PF00620(RhoGAP) | 4 | PRO B 392THR B 394ASN B 502LYS B 395 | None | 0.93A | 5xxiA-3msxB:undetectable | 5xxiA-3msxB:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qz1 | STEROID21-HYDROXYLASE (Bos taurus) |
PF00067(p450) | 4 | PRO A 58GLY A 57THR A 53LYS A 55 | None | 1.13A | 5xxiA-3qz1A:40.4 | 5xxiA-3qz1A:29.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rc3 | ATP-DEPENDENT RNAHELICASE SUPV3L1,MITOCHONDRIAL (Homo sapiens) |
PF00271(Helicase_C)PF12513(SUV3_C) | 4 | PRO A 401GLY A 402THR A 403LYS A 409 | None | 0.41A | 5xxiA-3rc3A:undetectable | 5xxiA-3rc3A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3stj | PROTEASE DEGQ (Escherichiacoli) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 4 | PRO A 310GLY A 311THR A 312LYS A 313 | None | 1.09A | 5xxiA-3stjA:undetectable | 5xxiA-3stjA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tej | ENTEROBACTINSYNTHASE COMPONENT F (Escherichiacoli) |
PF00550(PP-binding)PF00975(Thioesterase) | 4 | PRO A1277GLY A1278THR A1279LYS A1282 | None | 0.92A | 5xxiA-3tejA:undetectable | 5xxiA-3tejA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vm8 | PROBABLE DNADC->DU-EDITINGENZYME APOBEC-3C (Homo sapiens) |
PF08210(APOBEC_N) | 4 | PRO A 14GLY A 15THR A 16LYS A 22 | None | 1.10A | 5xxiA-3vm8A:undetectable | 5xxiA-3vm8A:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wmr | PROLINEIMINOPEPTIDASE (Streptomyceshalstedii) |
PF00561(Abhydrolase_1) | 4 | PRO A 217GLY A 216THR A 212ASN A 215 | None | 0.66A | 5xxiA-3wmrA:undetectable | 5xxiA-3wmrA:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wqb | OPEN READING FRAME 2 (Aeromonassobria) |
no annotation | 4 | PRO B 100GLY B 101THR B 102LYS B 44 | None | 1.05A | 5xxiA-3wqbB:undetectable | 5xxiA-3wqbB:15.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ar6 | RUBREDOXIN (Pyrococcusfuriosus) |
PF00301(Rubredoxin) | 4 | PRO A 25GLY A 26THR A 27LYS A 28 | None | 1.07A | 5xxiA-4ar6A:undetectable | 5xxiA-4ar6A:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e69 | 2-DEHYDRO-3-DEOXYGLUCONOKINASE (Oceanicolagranulosus) |
PF00294(PfkB) | 4 | PRO A 226GLY A 225ASN A 224LYS A 223 | None | 0.95A | 5xxiA-4e69A:undetectable | 5xxiA-4e69A:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esa | HEMOGLOBIN BETACHAIN (Eleginopsmaclovinus) |
PF00042(Globin) | 4 | PRO B 124GLY B 125THR B 126LYS B 132 | None | 0.43A | 5xxiA-4esaB:undetectable | 5xxiA-4esaB:14.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gek | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 4 | PRO A 56GLY A 57THR A 58ASN A 82 | None | 1.10A | 5xxiA-4gekA:undetectable | 5xxiA-4gekA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gek | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 4 | PRO A 56GLY A 57THR A 58LYS A 84 | None | 1.06A | 5xxiA-4gekA:undetectable | 5xxiA-4gekA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i84 | HEME/HEMOPEXIN-BINDING PROTEIN (Haemophilusinfluenzae) |
PF05860(Haemagg_act) | 4 | GLY A 209THR A 235ASN A 241LYS A 236 | None | 1.11A | 5xxiA-4i84A:undetectable | 5xxiA-4i84A:19.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwn | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 4 | PRO A 56GLY A 57THR A 58ASN A 82 | None | 1.08A | 5xxiA-4iwnA:undetectable | 5xxiA-4iwnA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwn | TRNA(CMO5U34)-METHYLTRANSFERASE (Escherichiacoli) |
PF13649(Methyltransf_25) | 4 | PRO A 56GLY A 57THR A 58LYS A 84 | None | 1.08A | 5xxiA-4iwnA:undetectable | 5xxiA-4iwnA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j0q | ELONGATION FACTORTU-A (Pseudomonasputida) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 4 | GLY A 95THR A 94ASN A 91LYS A 90 | None | 1.05A | 5xxiA-4j0qA:undetectable | 5xxiA-4j0qA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kgb | SUCCINYL-COA:3-KETOACID-COENZYME ATRANSFERASE (Drosophilamelanogaster) |
PF01144(CoA_trans) | 4 | PRO A 429GLY A 430THR A 431LYS A 432 | None | 1.04A | 5xxiA-4kgbA:undetectable | 5xxiA-4kgbA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l05 | SUPEROXIDE DISMUTASE[CU-ZN] (Brucellaabortus) |
PF00080(Sod_Cu) | 4 | PRO A 76GLY A 77THR A 79ASN A 78 | SO4 A 204 (-4.3A)NoneNoneNone | 0.91A | 5xxiA-4l05A:undetectable | 5xxiA-4l05A:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mxw | TUMOR NECROSISFACTOR RECEPTORSUPERFAMILY MEMBER 3 (Homo sapiens) |
no annotation | 4 | PRO S 64GLY S 65THR S 66ASN S 89 | None | 1.09A | 5xxiA-4mxwS:undetectable | 5xxiA-4mxwS:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n4u | PUTATIVE ABCTRANSPORTERPERIPLASMICSOLUTE-BINDINGPROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 4 | PRO A 259GLY A 260THR A 261LYS A 267 | None | 0.55A | 5xxiA-4n4uA:undetectable | 5xxiA-4n4uA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oy2 | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 1 (Saccharomycescerevisiae) |
PF12157(DUF3591) | 4 | PRO A 504GLY A 505THR A 506LYS A 507 | None | 0.98A | 5xxiA-4oy2A:undetectable | 5xxiA-4oy2A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r4z | PNGF-II (Elizabethkingiameningoseptica) |
PF09112(N-glycanase_N)PF09113(N-glycanase_C) | 4 | GLY A 214THR A 215ASN A 197LYS A 355 | None | 1.02A | 5xxiA-4r4zA:undetectable | 5xxiA-4r4zA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud1 | N PROTEIN (Middle Eastrespiratorysyndrome-relatedcoronavirus) |
PF00937(Corona_nucleoca) | 4 | PRO A 152GLY A 153THR A 154LYS A 155 | None | 0.97A | 5xxiA-4ud1A:undetectable | 5xxiA-4ud1A:14.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cxp | POSSIBLE XYLANDEGRADATION ENZYME(GLYCOSYL HYDROLASEFAMILY 30-LIKEDOMAIN AND RICINB-LIKE DOMAIN) (Clostridiumacetobutylicum) |
PF02055(Glyco_hydro_30) | 4 | PRO A 238GLY A 239THR A 240LYS A 246 | None | 0.86A | 5xxiA-5cxpA:undetectable | 5xxiA-5cxpA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dhz | ANTI-REV ANTIBODYFAB SINGLE-CHAINVARIABLE FRAGMENT,HEAVY CHAIN (Oryctolaguscuniculus) |
PF07686(V-set) | 4 | PRO H 14GLY H 15THR H 16LYS H 80 | None | 1.13A | 5xxiA-5dhzH:undetectable | 5xxiA-5dhzH:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmg | RB86 ANTIBODY FABFRAGMENT HEAVY CHAIN (Oryctolaguscuniculus) |
no annotation | 4 | PRO H 114GLY H 115THR H 116LYS H 316 | None | 1.03A | 5xxiA-5dmgH:undetectable | 5xxiA-5dmgH:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dvj | BINDING PROTEINCOMPONENT OF ABCSUGAR TRANSPORTER (Pseudomonasputida) |
PF01547(SBP_bac_1) | 4 | PRO A 27GLY A 28THR A 29ASN A 314 | None | 1.11A | 5xxiA-5dvjA:undetectable | 5xxiA-5dvjA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jfc | NADH-DEPENDENTFERREDOXIN:NADPOXIDOREDUCTASESUBUNIT BETA (Pyrococcusfuriosus) |
PF10418(DHODB_Fe-S_bind) | 4 | GLY S 105THR S 106ASN S 131LYS S 127 | None | 1.10A | 5xxiA-5jfcS:undetectable | 5xxiA-5jfcS:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwz | CELLULOSE-BINDINGFAMILY II (Streptomycessp. SirexAA-E) |
PF02012(BNR) | 4 | PRO A 486GLY A 487THR A 488ASN A 507 | None | 0.80A | 5xxiA-5jwzA:undetectable | 5xxiA-5jwzA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k4g | L-ASPARAGINASE (Wolinellasuccinogenes) |
PF00710(Asparaginase) | 4 | PRO A 255THR A 257ASN A 259LYS A 263 | None | 1.14A | 5xxiA-5k4gA:undetectable | 5xxiA-5k4gA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8d | COAGULATION FACTORVIII (Homo sapiens) |
PF00394(Cu-oxidase)PF07732(Cu-oxidase_3) | 4 | PRO A 505GLY A 506ASN A 467LYS A 466 | None | 1.00A | 5xxiA-5k8dA:undetectable | 5xxiA-5k8dA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mji | BRAMP DOMAIN PROTEIN (Streptomycesdavaonensis) |
PF03358(FMN_red) | 4 | PRO A 172GLY A 171THR A 170ASN A 134 | NoneNoneNone7O6 A 301 (-3.4A) | 1.07A | 5xxiA-5mjiA:undetectable | 5xxiA-5mjiA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | HETERODISULFIDEREDUCTASE, SUBUNIT A (Methanothermococcusthermolithotrophicus) |
PF07992(Pyr_redox_2)PF13187(Fer4_9) | 4 | PRO A 190THR A 188ASN A 192LYS A 187 | NoneFAD A 701 (-4.6A)NoneNone | 1.11A | 5xxiA-5odrA:undetectable | 5xxiA-5odrA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w0m | TERMINALURIDYLYLTRANSFERASE7 (Homo sapiens) |
PF00098(zf-CCHC)PF03828(PAP_assoc) | 4 | PRO A1038GLY A1039THR A1040LYS A1041 | None | 1.02A | 5xxiA-5w0mA:undetectable | 5xxiA-5w0mA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wls | POLLEN RECEPTOR-LIKEKINASE 3 (Arabidopsisthaliana) |
no annotation | 4 | PRO A 114GLY A 115LYS A 117LYS A 142 | None | 1.04A | 5xxiA-5wlsA:undetectable | 5xxiA-5wlsA:12.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fik | POLYKETIDE SYNTHASE (Cercosporanicotianae) |
no annotation | 4 | PRO A 533GLY A 534ASN A 537LYS A 541 | None | 0.90A | 5xxiA-6fikA:undetectable | 5xxiA-6fikA:8.84 |