SIMILAR PATTERNS OF AMINO ACIDS FOR 5XXI_A_LSNA501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjw PROTEIN (SEROTONIN
N-ACETYLTRANSFERASE)

(Ovis aries) 		PF00583
(Acetyltransf_1) 		4 PHE A  85
LEU A 124
LEU A  82
VAL A 126
 None
COT  A 400 (-4.5A)
None
COT  A 400 (-4.1A)
 1.28A 5xxiA-1cjwA:
0.0		 5xxiA-1cjwA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 PHE A  38
LEU A 117
LEU A 125
VAL A  74
 None
 1.30A 5xxiA-1ehkA:
0.0		 5xxiA-1ehkA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 PHE 2 185
LEU 3  43
LEU 3 100
VAL 3  40
 None
 1.29A 5xxiA-1ev12:
0.0		 5xxiA-1ev12:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1faw HEMOGLOBIN (ALPHA
SUBUNIT)

(Anser anser) 		PF00042
(Globin) 		4 PHE A  14
LEU A 136
LEU A 129
VAL A  62
 None
None
None
HEM  A 150 (-4.2A)
 1.35A 5xxiA-1fawA:
undetectable		 5xxiA-1fawA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ksp PROTEIN (DNA
POLYMERASE I-KLENOW
FRAGMENT
(E.C.2.7.7.7))

(Escherichia
coli) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		4 PHE A 373
LEU A 334
LEU A 339
VAL A 331
 None
 1.22A 5xxiA-1kspA:
0.3		 5xxiA-1kspA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll8 PAS KINASE

(Homo sapiens) 		PF13426
(PAS_9) 		4 PHE A  48
LEU A  22
LEU A  39
VAL A 106
 None
 1.33A 5xxiA-1ll8A:
undetectable		 5xxiA-1ll8A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 PHE A 570
LEU A 711
LEU A 632
VAL A 726
 None
 1.20A 5xxiA-1lnsA:
undetectable		 5xxiA-1lnsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		4 PHE A 591
LEU A 506
LEU A 540
VAL A 529
 None
 1.32A 5xxiA-1lq2A:
0.0		 5xxiA-1lq2A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		4 PHE A 151
LEU A  90
LEU A  81
VAL A 142
 None
 1.35A 5xxiA-1n4oA:
0.0		 5xxiA-1n4oA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 PHE A 280
LEU A  58
LEU A 326
VAL A  32
 None
 1.16A 5xxiA-1p49A:
undetectable		 5xxiA-1p49A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4u ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF02883
(Alpha_adaptinC2) 		4 PHE A 611
LEU A 581
LEU A 656
VAL A 626
 None
 1.19A 5xxiA-1p4uA:
undetectable		 5xxiA-1p4uA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxz MAJOR POLLEN
ALLERGEN JUN A 1

(Juniperus ashei) 		PF00544
(Pec_lyase_C) 		4 PHE A  72
LEU A 168
LEU A 101
VAL A 344
 None
 1.23A 5xxiA-1pxzA:
undetectable		 5xxiA-1pxzA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vka MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 PHE A 114
LEU A  96
LEU A  78
VAL A 108
 None
 1.09A 5xxiA-1vkaA:
undetectable		 5xxiA-1vkaA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wey CALCIPRESSIN 1

(Mus musculus) 		PF04847
(Calcipressin) 		4 PHE A  40
LEU A  72
LEU A  66
VAL A  17
 None
 1.29A 5xxiA-1weyA:
undetectable		 5xxiA-1weyA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woi AGMATINASE

(Deinococcus
radiodurans) 		PF00491
(Arginase) 		4 PHE A 233
LEU A 215
LEU A 258
VAL A 207
 None
 1.26A 5xxiA-1woiA:
undetectable		 5xxiA-1woiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 PHE A 147
LEU A 272
LEU A 250
VAL A 125
 None
 1.16A 5xxiA-1wstA:
undetectable		 5xxiA-1wstA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 PHE B 326
LEU B 270
LEU B 310
VAL B 383
 None
 1.34A 5xxiA-1xnjB:
undetectable		 5xxiA-1xnjB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF13306
(LRR_5) 		4 PHE C 190
LEU C 148
LEU C 177
VAL C 173
 None
 1.36A 5xxiA-1xwdC:
undetectable		 5xxiA-1xwdC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq1 GLUTATHIONE
S-TRANSFERASE

(Caenorhabditis
elegans) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 PHE A  99
LEU A 141
LEU A 183
VAL A  92
 None
 1.32A 5xxiA-1yq1A:
undetectable		 5xxiA-1yq1A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf4 NADPH-CYTOCHROME
P450 REDUCTASE

(Saccharomyces
cerevisiae) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		4 PHE A 133
LEU A  62
LEU A 145
VAL A  96
 None
 1.29A 5xxiA-2bf4A:
undetectable		 5xxiA-2bf4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg9 ADP-RIBOSYL CYCLASE
1

(Mus musculus) 		PF02267
(Rib_hydrolayse) 		4 PHE A 277
LEU A 127
LEU A 212
VAL A 208
 None
 1.13A 5xxiA-2eg9A:
undetectable		 5xxiA-2eg9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyq TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02559
(CarD_CdnL_TRCF)
PF03461
(TRCF) 		4 PHE A 669
LEU A 613
LEU A 725
VAL A 637
 None
 1.36A 5xxiA-2eyqA:
undetectable		 5xxiA-2eyqA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF00917
(MATH) 		4 PHE A 283
LEU A 238
LEU A 229
VAL A 307
 None
 1.21A 5xxiA-2f1zA:
undetectable		 5xxiA-2f1zA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5a PROTEIN (ANTIBODY
2F5 (HEAVY CHAIN))
PROTEIN (ANTIBODY
2F5 (LIGHT CHAIN))

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE H 141
LEU L 181
LEU L 125
VAL L 132
 None
 1.37A 5xxiA-2f5aH:
undetectable		 5xxiA-2f5aH:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 PHE A 337
LEU A 396
LEU A 355
VAL A 362
 None
 1.18A 5xxiA-2h21A:
undetectable		 5xxiA-2h21A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyu INOSINE TRIPHOSPHATE
PYROPHOSPHATASE RDGB

(Escherichia
coli) 		PF01725
(Ham1p_like) 		4 PHE A  24
LEU A   6
LEU A 190
VAL A   4
 None
 1.36A 5xxiA-2pyuA:
undetectable		 5xxiA-2pyuA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 PHE A 150
LEU A  62
LEU A  53
VAL A  99
 None
 1.36A 5xxiA-2qagA:
undetectable		 5xxiA-2qagA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		4 PHE A  43
LEU A  56
LEU A  69
VAL A  24
 None
 1.08A 5xxiA-2qjcA:
undetectable		 5xxiA-2qjcA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 PHE A 326
LEU A 270
LEU A 310
VAL A 383
 None
 1.32A 5xxiA-2qjfA:
undetectable		 5xxiA-2qjfA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjz MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 PHE A 114
LEU A  96
LEU A  78
VAL A 108
 None
 1.07A 5xxiA-2qjzA:
undetectable		 5xxiA-2qjzA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 PHE A  88
LEU A  95
LEU A 118
VAL A  93
 None
 1.20A 5xxiA-2qxlA:
undetectable		 5xxiA-2qxlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0q PUTATIVE TRANSPOSON
TN552 DNA-INVERTASE
BIN3

(Staphylococcus
aureus) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		4 PHE C  31
LEU C  88
LEU C  50
VAL C  61
 None
 1.25A 5xxiA-2r0qC:
undetectable		 5xxiA-2r0qC:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 PHE A 114
LEU A  96
LEU A  78
VAL A 108
 None
 1.06A 5xxiA-2r8uA:
undetectable		 5xxiA-2r8uA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vzz RV0802C

(Mycobacterium
tuberculosis) 		PF13302
(Acetyltransf_3) 		4 PHE A 210
LEU A  19
LEU A  21
VAL A 130
 None
 1.37A 5xxiA-2vzzA:
undetectable		 5xxiA-2vzzA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3m PROTEIN TRANSPORT
PROTEIN HOFQ

(Aggregatibacter
actinomycetemcomitans) 		PF03958
(Secretin_N) 		4 PHE A  31
LEU A 185
LEU A 155
VAL A 143
 None
 1.35A 5xxiA-2y3mA:
undetectable		 5xxiA-2y3mA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS

(Mycobacterium
tuberculosis) 		PF12282
(H_kinase_N) 		4 PHE A 118
LEU A   4
LEU A  14
VAL A  25
 None
 1.19A 5xxiA-2ykfA:
undetectable		 5xxiA-2ykfA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 PHE C  15
LEU C 101
LEU C  89
VAL C  77
 None
 1.20A 5xxiA-3aizC:
undetectable		 5xxiA-3aizC:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 PHE B 279
LEU B 360
LEU B 367
VAL B 413
 None
 1.32A 5xxiA-3amjB:
undetectable		 5xxiA-3amjB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b98 PROSTAGLANDIN I2
SYNTHASE

(Danio rerio) 		PF00067
(p450) 		4 PHE A 442
LEU A 171
LEU A 166
VAL A 435
 None
 1.37A 5xxiA-3b98A:
29.6		 5xxiA-3b98A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk4 RUBISCO-LIKE PROTEIN

(Bacillus cereus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 PHE A 297
LEU A 198
LEU A 135
VAL A 173
 None
 1.08A 5xxiA-3fk4A:
undetectable		 5xxiA-3fk4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 PHE A 126
LEU A 308
LEU A  11
VAL A 263
 None
 1.29A 5xxiA-3fk5A:
undetectable		 5xxiA-3fk5A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 PHE A 326
LEU A 380
LEU A 337
VAL A 370
 None
 1.06A 5xxiA-3fxiA:
undetectable		 5xxiA-3fxiA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtd FUMARATE HYDRATASE
CLASS II

(Rickettsia
prowazekii) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 PHE A 277
LEU A 375
LEU A 160
VAL A 340
 None
 1.16A 5xxiA-3gtdA:
undetectable		 5xxiA-3gtdA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A  99
LEU A 139
LEU A 114
VAL A 387
 None
 1.36A 5xxiA-3ifeA:
undetectable		 5xxiA-3ifeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 PHE A 663
LEU A 574
LEU A 569
VAL A 120
 None
 1.34A 5xxiA-3jb9A:
undetectable		 5xxiA-3jb9A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		4 PHE X 146
LEU X  50
LEU X 156
VAL X 115
 None
 1.33A 5xxiA-3m7mX:
undetectable		 5xxiA-3m7mX:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhu DIHYDROOROTATE
DEHYDROGENASE

(Leishmania
major) 		PF01180
(DHO_dh) 		4 PHE A  96
LEU A 302
LEU A   7
VAL A 269
 None
 1.23A 5xxiA-3mhuA:
undetectable		 5xxiA-3mhuA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A 228
LEU A 160
LEU A 167
VAL A 188
 None
None
None
MCA  A 486 ( 4.1A)
 0.96A 5xxiA-3nyqA:
undetectable		 5xxiA-3nyqA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qak ADENOSINE RECEPTOR
A2A,LYSOZYME CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A 180
LEU A  96
LEU A 131
VAL A 188
 None
 1.32A 5xxiA-3qakA:
undetectable		 5xxiA-3qakA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdl OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE

(Helicobacter
pylori) 		PF00881
(Nitroreductase) 		4 PHE A 164
LEU A  62
LEU A  83
VAL A 172
 None
 1.35A 5xxiA-3qdlA:
undetectable		 5xxiA-3qdlA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3re2 PREDICTED PROTEIN

(Nematostella
vectensis) 		PF05053
(Menin) 		4 PHE A 412
LEU A 473
LEU A 379
VAL A 406
 None
 1.28A 5xxiA-3re2A:
undetectable		 5xxiA-3re2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rom ADP-RIBOSYL CYCLASE
1

(Homo sapiens) 		PF02267
(Rib_hydrolayse) 		4 PHE A 273
LEU A 123
LEU A 208
VAL A 204
 None
 1.06A 5xxiA-3romA:
undetectable		 5xxiA-3romA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 PHE A 143
LEU A 395
LEU A 162
VAL A 169
 None
 1.14A 5xxiA-3rp9A:
undetectable		 5xxiA-3rp9A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7x PROBABLE
OXIDOREDUCTASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 PHE A 137
LEU A 296
LEU A 289
VAL A 163
 None
 1.15A 5xxiA-4b7xA:
undetectable		 5xxiA-4b7xA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c76 FMN REDUCTASE
(NADPH)

(Pseudomonas
putida) 		PF03358
(FMN_red) 		4 PHE A 164
LEU A  80
LEU A  24
VAL A 170
 None
 1.15A 5xxiA-4c76A:
undetectable		 5xxiA-4c76A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		4 PHE A 206
LEU A 301
LEU A 304
VAL A  29
 None
 1.13A 5xxiA-4cyfA:
undetectable		 5xxiA-4cyfA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF06187
(DUF993) 		4 PHE A 317
LEU A 306
LEU A 277
VAL A 310
 None
None
GOL  A 500 (-4.7A)
None
 1.21A 5xxiA-4dnhA:
undetectable		 5xxiA-4dnhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I

(Hordeum vulgare) 		PF00161
(RIP) 		4 PHE A  64
LEU A 105
LEU A  88
VAL A   9
 None
 1.09A 5xxiA-4fbhA:
undetectable		 5xxiA-4fbhA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02759
(RUN) 		4 PHE A 120
LEU A 178
LEU A 127
VAL A  51
 None
 1.26A 5xxiA-4giwA:
undetectable		 5xxiA-4giwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn2 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 PHE A 227
LEU A 177
LEU A 195
VAL A 239
 None
 1.24A 5xxiA-4gn2A:
undetectable		 5xxiA-4gn2A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3z TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Paraburkholderia
phymatum) 		PF01746
(tRNA_m1G_MT) 		4 PHE A 106
LEU A  16
LEU A 114
VAL A 157
 None
 1.04A 5xxiA-4h3zA:
undetectable		 5xxiA-4h3zA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h5s CELL ADHESION
MOLECULE 1
CYTOTOXIC AND
REGULATORY T-CELL
MOLECULE

(Homo sapiens) 		PF07686
(V-set) 		4 PHE A  39
LEU B  63
LEU B  33
VAL B  29
 None
 1.31A 5xxiA-4h5sA:
undetectable		 5xxiA-4h5sA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpf POTASSIUM CHANNEL
SUBFAMILY U MEMBER 1

(Homo sapiens) 		PF03493
(BK_channel_a) 		4 PHE A 734
LEU A 492
LEU A 862
VAL A 927
 None
 1.13A 5xxiA-4hpfA:
undetectable		 5xxiA-4hpfA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i66 UNCHARACTERIZED
PROTEIN HOCH_4089

(Haliangium
ochraceum) 		PF13709
(DUF4159) 		4 PHE A  94
LEU A 109
LEU A  38
VAL A 139
 None
 1.33A 5xxiA-4i66A:
undetectable		 5xxiA-4i66A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		4 PHE A 325
LEU A 256
LEU A 261
VAL A 456
 None
 1.29A 5xxiA-4jreA:
undetectable		 5xxiA-4jreA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp7 MATRIX PROTEIN M

(Human
metapneumovirus) 		PF03393
(Pneumo_matrix) 		4 PHE A  88
LEU A  48
LEU A  55
VAL A  83
 None
 1.32A 5xxiA-4lp7A:
undetectable		 5xxiA-4lp7A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		4 PHE A 164
LEU A 295
LEU A 208
VAL A 215
 None
 1.20A 5xxiA-4mdpA:
undetectable		 5xxiA-4mdpA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mf4 HPCH/HPAI
ALDOLASE/CITRATE
LYASE FAMILY PROTEIN

(Burkholderia
cenocepacia) 		PF03328
(HpcH_HpaI) 		4 PHE A  98
LEU A  61
LEU A  89
VAL A  74
 None
 1.33A 5xxiA-4mf4A:
undetectable		 5xxiA-4mf4A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE

(Pseudomonas
aeruginosa) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 PHE A 332
LEU A 293
LEU A 264
VAL A 272
 None
 1.10A 5xxiA-4mrqA:
undetectable		 5xxiA-4mrqA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Chaetomium
thermophilum) 		PF08662
(eIF2A) 		4 PHE A 468
LEU A 406
LEU A 425
VAL A 429
 None
 1.21A 5xxiA-4noxA:
undetectable		 5xxiA-4noxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2

(Homo sapiens) 		no annotation 4 PHE A 151
LEU A  60
LEU A 656
VAL A  64
 None
 1.31A 5xxiA-4p5wA:
undetectable		 5xxiA-4p5wA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 PHE A 298
LEU A 209
LEU A 417
VAL A 217
 None
 1.35A 5xxiA-4qg5A:
undetectable		 5xxiA-4qg5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wch ISOLATED CHAIN D OF
GIGANT HEMOGLOBIN
FROM GLOSSOSCOLEX
PAULISTUS

(Glossoscolex
paulistus) 		PF00042
(Globin) 		4 PHE D 133
LEU D 120
LEU D 113
VAL D  11
 HEM  D 201 ( 3.7A)
None
None
None
 1.26A 5xxiA-4wchD:
undetectable		 5xxiA-4wchD:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhc ALPHA-L-RHAMNOSIDASE

(Klebsiella
oxytoca) 		PF17389
(Bac_rhamnosid6H) 		4 PHE A 288
LEU A 373
LEU A 365
VAL A 316
 None
 1.36A 5xxiA-4xhcA:
undetectable		 5xxiA-4xhcA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aor DOSAGE COMPENSATION
REGULATOR

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		4 PHE A 672
LEU A 780
LEU A 644
VAL A 635
 None
 1.32A 5xxiA-5aorA:
undetectable		 5xxiA-5aorA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddb MENIN

(Homo sapiens) 		PF05053
(Menin) 		4 PHE A 447
LEU A 579
LEU A 414
VAL A 441
 None
 1.21A 5xxiA-5ddbA:
undetectable		 5xxiA-5ddbA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e1b N-TERMINAL
XAA-PRO-LYS
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF05891
(Methyltransf_PK) 		4 PHE A  48
LEU A 157
LEU A 202
VAL A 131
 None
 1.26A 5xxiA-5e1bA:
undetectable		 5xxiA-5e1bA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		4 PHE A 180
LEU A  96
LEU A 131
VAL A 188
 None
 1.12A 5xxiA-5g53A:
undetectable		 5xxiA-5g53A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ENGINEERED DOMAIN OF
HUMAN G ALPHA S LONG
ISOFORM

(Homo sapiens) 		PF00503
(G-alpha) 		4 PHE C 363
LEU C 270
LEU C 346
VAL C 248
 None
 1.17A 5xxiA-5g53C:
undetectable		 5xxiA-5g53C:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis) 		PF01370
(Epimerase) 		4 PHE A 249
LEU A  14
LEU A  21
VAL A 190
 None
 1.23A 5xxiA-5gmoA:
undetectable		 5xxiA-5gmoA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		4 PHE A 283
LEU A 238
LEU A 229
VAL A 307
 None
 1.20A 5xxiA-5j7tA:
undetectable		 5xxiA-5j7tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		4 PHE A 126
LEU A  74
LEU A  19
VAL A  13
 None
 1.36A 5xxiA-5jijA:
undetectable		 5xxiA-5jijA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ket ALDO-KETO REDUCTASE
1

(Coptotermes
gestroi) 		PF00248
(Aldo_ket_red) 		4 PHE A  10
LEU A  96
LEU A 112
VAL A 155
 None
 1.32A 5xxiA-5ketA:
undetectable		 5xxiA-5ketA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kq1 MRNA DECAPPING
COMPLEX SUBUNIT 2

(Schizosaccharomyces
pombe) 		PF00293
(NUDIX)
PF05026
(DCP2) 		4 PHE B 207
LEU B 173
LEU B 104
VAL B 222
 None
 1.21A 5xxiA-5kq1B:
undetectable		 5xxiA-5kq1B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		4 PHE A 359
LEU A 216
LEU A 124
VAL A 169
 None
 1.17A 5xxiA-5l35A:
undetectable		 5xxiA-5l35A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtv EH DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF00350
(Dynamin_N)
PF16880
(EHD_N) 		4 PHE A  48
LEU A 345
LEU A 338
VAL A 309
 None
 1.09A 5xxiA-5mtvA:
undetectable		 5xxiA-5mtvA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nge UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		no annotation 4 PHE A 283
LEU A 238
LEU A 229
VAL A 307
 None
 1.01A 5xxiA-5ngeA:
undetectable		 5xxiA-5ngeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum) 		no annotation 4 PHE A  34
LEU A  39
LEU A 163
VAL A  46
 None
 1.32A 5xxiA-5nmpA:
undetectable		 5xxiA-5nmpA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot0 L-ASPARAGINASE

(Thermococcus
kodakarensis) 		no annotation 4 PHE A 137
LEU A 108
LEU A 150
VAL A 106
 None
 1.32A 5xxiA-5ot0A:
undetectable		 5xxiA-5ot0A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t12 PHOSPHOENOLPYRUVATE-
-PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF05524
(PEP-utilisers_N) 		4 PHE A 279
LEU A 216
LEU A 248
VAL A 272
 None
 1.24A 5xxiA-5t12A:
undetectable		 5xxiA-5t12A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6o POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 1

(Homo sapiens) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF08412
(Ion_trans_N) 		4 PHE A 166
LEU A 307
LEU A 349
VAL A 158
 None
 1.24A 5xxiA-5u6oA:
undetectable		 5xxiA-5u6oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA

(Escherichia
virus T4;
Mycobacterium
kansasii) 		PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG) 		4 PHE A  38
LEU A  65
LEU A  33
VAL A  21
 None
 1.25A 5xxiA-5vbaA:
undetectable		 5xxiA-5vbaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 PHE A 438
LEU A 467
LEU A 742
VAL A 396
 None
 1.26A 5xxiA-5weoA:
undetectable		 5xxiA-5weoA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 4 PHE A  83
LEU A  42
LEU A  70
VAL A  65
 None
 1.26A 5xxiA-5y3jA:
undetectable		 5xxiA-5y3jA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 PHE A 680
LEU A 648
LEU A 659
VAL A 688
 None
 0.96A 5xxiA-5z06A:
undetectable		 5xxiA-5z06A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(S) SUBUNIT
ALPHA ISOFORMS SHORT

(Homo sapiens) 		no annotation 4 PHE A 363
LEU A 270
LEU A 346
VAL A 248
 None
None
None
CL  A 403 ( 4.4A)
 1.17A 5xxiA-6au6A:
undetectable		 5xxiA-6au6A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6l V-TYPE PROTON ATPASE
SUBUNIT A, VACUOLAR
ISOFORM

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 213
LEU A 260
LEU A 199
VAL A 187
 None
 1.36A 5xxiA-6c6lA:
undetectable		 5xxiA-6c6lA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 4 PHE A 187
LEU A 111
LEU A  99
VAL A 232
 None
 1.13A 5xxiA-6f4eA:
undetectable		 5xxiA-6f4eA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum) 		no annotation 4 PHE J 612
LEU J 258
LEU J 245
VAL J 630
 None
 1.34A 5xxiA-6fhsJ:
undetectable		 5xxiA-6fhsJ:
10.92