SIMILAR PATTERNS OF AMINO ACIDS FOR 5XXI_A_LSNA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ALA C 236
VAL C 520
GLY C 416
LEU C 356
LEU C 294
 None
 0.84A 5xxiA-1a5lC:
0.0		 5xxiA-1a5lC:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus) 		PF00464
(SHMT) 		5 ALA A 356
ASP A 123
GLY A 125
LEU A 318
LEU A 320
 None
 1.02A 5xxiA-1cj0A:
0.0		 5xxiA-1cj0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dle COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin) 		5 VAL A  66
GLY A  44
ALA A  31
LEU A 112
LEU A 108
 None
 1.09A 5xxiA-1dleA:
undetectable		 5xxiA-1dleA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ebl BETA-KETOACYL-ACP
SYNTHASE III

(Escherichia
coli) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 288
GLY A   9
ALA A  58
LEU A  98
LEU A 135
 None
 1.10A 5xxiA-1eblA:
undetectable		 5xxiA-1eblA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx4 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.3

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		5 ALA A1057
GLY A1075
ALA A1076
LEU A1104
LEU A1079
 None
 1.05A 5xxiA-1fx4A:
0.0		 5xxiA-1fx4A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 158
VAL A 218
VAL A 195
ASP A 236
ALA A 203
 None
 1.09A 5xxiA-1ik6A:
0.0		 5xxiA-1ik6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		5 VAL A 439
VAL A  19
GLY A  93
ALA A  94
LEU A 436
 None
 1.10A 5xxiA-1l1lA:
0.0		 5xxiA-1l1lA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 173
VAL A 208
GLY A 189
ALA A 188
LEU A 236
 None
 1.06A 5xxiA-1lpfA:
0.0		 5xxiA-1lpfA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III

(Streptomyces
sp. R1128) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 302
GLY A  18
ALA A  67
LEU A 107
LEU A 144
 None
 1.08A 5xxiA-1mzjA:
undetectable		 5xxiA-1mzjA:
20.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		6 ASN A 204
ASP A 290
GLY A 293
ALA A 294
LEU A 359
LEU A 363
 None
None
DIF  A 501 (-3.8A)
DIF  A 501 ( 3.3A)
DIF  A 501 (-4.4A)
HEM  A 500 (-4.0A)
 0.61A 5xxiA-1nr6A:
55.4		 5xxiA-1nr6A:
76.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4a PUR OPERON REPRESSOR

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF09182
(PuR_N) 		5 ALA A 148
VAL A 114
GLY A 110
LEU A  91
LEU A  87
 None
 1.03A 5xxiA-1p4aA:
undetectable		 5xxiA-1p4aA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		5 ALA A 132
VAL A 203
ASP A 195
GLY A 198
ALA A 199
 None
None
CA  A 905 (-2.6A)
None
None
 0.59A 5xxiA-1q5aA:
undetectable		 5xxiA-1q5aA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		5 ALA A 322
VAL A 329
GLY A 120
LEU A 101
LEU A 315
 None
 1.01A 5xxiA-1qnlA:
undetectable		 5xxiA-1qnlA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 VAL A 169
GLN A 342
VAL A 265
GLY A 251
LEU A 173
 None
 1.03A 5xxiA-1re5A:
undetectable		 5xxiA-1re5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sez PROTOPORPHYRINOGEN
OXIDASE,
MITOCHONDRIAL

(Nicotiana
tabacum) 		PF01593
(Amino_oxidase) 		5 ALA A 486
VAL A  41
GLY A  22
ALA A  21
LEU A 253
 None
None
FAD  A 600 (-3.3A)
None
None
 0.93A 5xxiA-1sezA:
undetectable		 5xxiA-1sezA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyo MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		5 VAL A  68
VAL A 100
GLY A  48
ALA A  49
LEU A  65
 None
 1.09A 5xxiA-1wyoA:
undetectable		 5xxiA-1wyoA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2g LIPOATE-PROTEIN
LIGASE A

(Escherichia
coli) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 VAL A 104
ASN A 121
GLY A 150
LEU A 187
LEU A 108
 None
 1.01A 5xxiA-1x2gA:
undetectable		 5xxiA-1x2gA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		5 VAL A  15
ASN A 409
GLY A 349
ALA A 348
LEU A 345
 None
 1.07A 5xxiA-2b8nA:
undetectable		 5xxiA-2b8nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byk CHRAC-14
CHRAC-16

(Drosophila
melanogaster) 		PF00808
(CBFD_NFYB_HMF) 		5 VAL A  82
VAL B  29
GLY A  59
ALA A  60
LEU A  89
 None
 1.03A 5xxiA-2bykA:
undetectable		 5xxiA-2bykA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1f THREONINE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00291
(PALP) 		5 ALA A 112
VAL A  77
GLY A 108
ALA A 107
LEU A  34
 None
 1.03A 5xxiA-2d1fA:
undetectable		 5xxiA-2d1fA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2duw PUTATIVE COA-BINDING
PROTEIN

(Klebsiella
pneumoniae) 		PF13380
(CoA_binding_2) 		5 ALA A  95
VAL A  76
GLY A  85
ALA A  82
LEU A 100
 None
 1.02A 5xxiA-2duwA:
undetectable		 5xxiA-2duwA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 ALA A 189
VAL A 194
VAL A 157
GLY A 177
ALA A 173
LEU A 212
 None
 1.45A 5xxiA-2ejvA:
undetectable		 5xxiA-2ejvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 331
VAL A 216
ASN A 443
GLY A 391
ALA A 392
 None
 0.93A 5xxiA-2iwzA:
undetectable		 5xxiA-2iwzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF01903
(CbiX) 		5 ALA A  27
VAL A 254
ALA A 123
LEU A  72
LEU A 114
 None
 0.93A 5xxiA-2jh3A:
undetectable		 5xxiA-2jh3A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qny 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Mycobacterium
tuberculosis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 285
VAL A 137
ALA A  55
LEU A  98
LEU A 135
 None
 1.02A 5xxiA-2qnyA:
undetectable		 5xxiA-2qnyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 558
ASP A 536
GLY A 587
ALA A 586
LEU A 500
 None
 1.03A 5xxiA-2v9yA:
undetectable		 5xxiA-2v9yA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsb GALACTITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		5 ALA A 161
VAL A 117
MET A 120
GLY A 143
ALA A 188
 None
 1.02A 5xxiA-2wsbA:
undetectable		 5xxiA-2wsbA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ALA A 415
GLY A  14
ALA A  15
LEU A 146
LEU A 149
 None
FAD  A 601 (-3.1A)
FAD  A 601 (-4.1A)
None
None
 1.08A 5xxiA-2wu5A:
undetectable		 5xxiA-2wu5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		5 ALA A 444
VAL A  33
GLY A  14
ALA A  13
LEU A 225
 None
None
FAD  A 600 (-3.6A)
None
None
 1.03A 5xxiA-2yg6A:
undetectable		 5xxiA-2yg6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co1 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		5 VAL A  61
VAL A  93
GLY A  41
ALA A  42
LEU A  58
 None
 1.01A 5xxiA-3co1A:
undetectable		 5xxiA-3co1A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A  10
ASN A 245
ALA A  18
LEU A  58
LEU A  39
 None
 0.95A 5xxiA-3d5tA:
undetectable		 5xxiA-3d5tA:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		5 ALA A 105
ASN A 206
ASP A 295
ALA A 299
LEU A 368
 None
None
None
HEM  A 500 ( 3.3A)
HEM  A 500 (-3.6A)
 1.04A 5xxiA-3e4eA:
50.5		 5xxiA-3e4eA:
58.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		5 ALA A 105
ASN A 206
VAL A 239
ASP A 295
ALA A 299
 None
None
None
None
HEM  A 500 ( 3.3A)
 0.91A 5xxiA-3e4eA:
50.5		 5xxiA-3e4eA:
58.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		5 ALA A 263
VAL A 242
MET A 465
LEU A 377
LEU A 244
 None
 1.10A 5xxiA-3f8tA:
undetectable		 5xxiA-3f8tA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhc NUCLEAR PORE COMPLEX
PROTEIN NUP214

(Homo sapiens) 		PF12894
(ANAPC4_WD40) 		5 ALA A  99
VAL A 198
ASP A 154
LEU A 223
LEU A 207
 None
 1.09A 5xxiA-3fhcA:
undetectable		 5xxiA-3fhcA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 299
VAL A  83
VAL A 209
LEU A  74
LEU A  78
 None
NIL  A   1 (-4.9A)
None
None
None
 1.07A 5xxiA-3gp0A:
undetectable		 5xxiA-3gp0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00106
(adh_short) 		5 VAL A  69
MET A 167
GLY A 116
ALA A 115
LEU A  61
 VAL  A  69 ( 0.6A)
MET  A 167 ( 0.0A)
GLY  A 116 ( 0.0A)
ALA  A 115 ( 0.0A)
LEU  A  61 ( 0.6A)
 1.01A 5xxiA-3h7aA:
undetectable		 5xxiA-3h7aA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ioy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Novosphingobium
aromaticivorans) 		PF00106
(adh_short) 		5 ALA A  75
GLY A  13
ALA A  15
LEU A  50
LEU A  47
 None
 1.06A 5xxiA-3ioyA:
undetectable		 5xxiA-3ioyA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9e VP5

(Bluetongue
virus) 		PF00901
(Orbi_VP5) 		5 ASN D 476
GLY D 504
ALA D 501
LEU D 397
LEU D 491
 None
 1.09A 5xxiA-3j9eD:
undetectable		 5xxiA-3j9eD:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		5 ALA A  36
GLY A 229
ALA A 230
LEU A 146
LEU A 144
 None
 1.09A 5xxiA-3k31A:
undetectable		 5xxiA-3k31A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7h INDIAN HEDGEHOG
PROTEIN

(Homo sapiens) 		PF01085
(HH_signal) 		5 VAL B 186
ASN B 161
GLY B 164
ALA B 167
LEU B 114
 None
 1.10A 5xxiA-3k7hB:
undetectable		 5xxiA-3k7hB:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh1 PREDICTED
METAL-DEPENDENT
PHOSPHOHYDROLASE

(Magnetospirillum
magnetotacticum) 		PF13023
(HD_3) 		5 ALA A  41
VAL A  77
GLY A  82
ALA A  81
LEU A 106
 None
 1.09A 5xxiA-3kh1A:
undetectable		 5xxiA-3kh1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my9 MUCONATE
CYCLOISOMERASE

(Azorhizobium
caulinodans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		6 ALA A 237
VAL A 260
GLY A 292
ALA A 291
LEU A 284
LEU A 256
 MG  A 377 (-4.2A)
None
None
None
None
None
 1.46A 5xxiA-3my9A:
undetectable		 5xxiA-3my9A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n1q DESERT HEDGEHOG
PROTEIN

(Homo sapiens) 		no annotation 5 VAL B 182
ASN B 157
GLY B 160
ALA B 163
LEU B 110
 None
 1.09A 5xxiA-3n1qB:
undetectable		 5xxiA-3n1qB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		5 VAL A 396
GLY A  12
ALA A  15
LEU A  72
LEU A  68
 None
 1.06A 5xxiA-3nrnA:
undetectable		 5xxiA-3nrnA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		6 ALA A 282
VAL A 310
GLY A 319
ALA A 320
LEU A 351
LEU A 308
 None
 1.25A 5xxiA-3opyA:
undetectable		 5xxiA-3opyA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		6 ALA B 254
VAL B 282
GLY B 291
ALA B 292
LEU B 323
LEU B 280
 None
 1.25A 5xxiA-3opyB:
undetectable		 5xxiA-3opyB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		5 ALA A 304
VAL A 327
ALA A 349
LEU A 250
LEU A 247
 None
 1.08A 5xxiA-3othA:
undetectable		 5xxiA-3othA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ALA A 555
VAL A 470
VAL A 598
ALA A 503
LEU A 511
 None
 1.06A 5xxiA-3pocA:
undetectable		 5xxiA-3pocA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 VAL A 101
GLY A 109
ALA A 105
LEU A 175
LEU A 119
 None
 1.03A 5xxiA-3q0gA:
undetectable		 5xxiA-3q0gA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 ALA B 638
VAL B 951
ALA B 922
LEU B1008
LEU B 936
 None
 1.08A 5xxiA-3qd2B:
undetectable		 5xxiA-3qd2B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		5 ALA A 321
ASP A 345
GLY A 173
ALA A 172
LEU A 154
 None
 1.10A 5xxiA-3rhaA:
undetectable		 5xxiA-3rhaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		5 ALA A 445
VAL A  35
GLY A  16
ALA A  15
LEU A 227
 None
None
FDA  A 483 (-3.3A)
None
None
 1.05A 5xxiA-3rhaA:
undetectable		 5xxiA-3rhaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Bacteroides
thetaiotaomicron) 		PF00348
(polyprenyl_synt) 		5 ALA A  57
GLY A 201
ALA A 177
LEU A 139
LEU A 135
 None
 0.97A 5xxiA-3rmgA:
undetectable		 5xxiA-3rmgA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		5 VAL A  41
ASN A  20
GLY A  14
ALA A  63
LEU A  79
 None
 1.07A 5xxiA-3sz3A:
undetectable		 5xxiA-3sz3A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE

(Symbiobacterium
thermophilum) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		5 VAL A  33
VAL A 262
MET A 261
GLY A  15
LEU A  46
 None
 1.01A 5xxiA-3wbbA:
undetectable		 5xxiA-3wbbA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Thermus
thermophilus) 		PF00696
(AA_kinase) 		5 ALA A 249
VAL A 253
ALA A  18
LEU A 152
LEU A  33
 None
 1.09A 5xxiA-3wwnA:
undetectable		 5xxiA-3wwnA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyo LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4B

(Mus musculus) 		PF00560
(LRR_1)
PF07679
(I-set)
PF13855
(LRR_8) 		5 ALA A 131
VAL A 151
ALA A 179
LEU A 189
LEU A 167
 None
 1.09A 5xxiA-3zyoA:
undetectable		 5xxiA-3zyoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 ALA A 274
VAL A 243
GLY A 258
ALA A 259
LEU A 303
 None
 1.06A 5xxiA-4bjuA:
undetectable		 5xxiA-4bjuA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bnq NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Staphylococcus
aureus) 		PF01725
(Ham1p_like) 		5 ALA A 165
GLY A 137
ALA A 113
LEU A 105
LEU A 101
 None
 1.09A 5xxiA-4bnqA:
undetectable		 5xxiA-4bnqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnm TROPHOBLAST
GLYCOPROTEIN

(Homo sapiens) 		PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		5 VAL A 133
GLY A 136
ALA A 161
LEU A 178
LEU A 149
 None
 0.95A 5xxiA-4cnmA:
undetectable		 5xxiA-4cnmA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 ALA A  55
VAL A  33
GLY A 140
ALA A 139
LEU A 160
 None
 1.09A 5xxiA-4d9rA:
undetectable		 5xxiA-4d9rA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db1 MYOSIN-7

(Homo sapiens) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ALA A 430
VAL A 273
GLY A 360
LEU A 396
LEU A 399
 None
 1.06A 5xxiA-4db1A:
undetectable		 5xxiA-4db1A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e14 KYNURENINE
FORMAMIDASE

(Drosophila
melanogaster) 		PF07859
(Abhydrolase_3) 		5 ALA A 241
GLY A 155
ALA A 154
LEU A 105
LEU A 294
 None
 1.00A 5xxiA-4e14A:
undetectable		 5xxiA-4e14A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewc PUTATIVE
NUCLEOPROTEIN

(Salmon isavirus) 		no annotation 5 ALA A 172
VAL A 423
ALA A 434
LEU A 487
LEU A 421
 None
 1.03A 5xxiA-4ewcA:
undetectable		 5xxiA-4ewcA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fai CG5976, ISOFORM B

(Drosophila
melanogaster) 		PF04389
(Peptidase_M28) 		5 VAL A  77
GLY A 204
ALA A 205
LEU A 224
LEU A 226
 None
 0.96A 5xxiA-4faiA:
undetectable		 5xxiA-4faiA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		5 ALA A 194
GLN A 164
GLY A 220
ALA A 219
LEU A 167
 None
None
None
DPF  A 601 (-3.3A)
None
 1.07A 5xxiA-4fnmA:
undetectable		 5xxiA-4fnmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1i MALATE DEHYDROGENASE

(Leishmania
major) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ALA A 241
VAL A  20
VAL A 128
GLY A  10
ALA A  11
 NAD  A 400 ( 3.7A)
None
NAD  A 400 (-4.0A)
NAD  A 400 (-3.4A)
None
 0.95A 5xxiA-4i1iA:
undetectable		 5xxiA-4i1iA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 6 ALA A 174
VAL A 200
GLY A 165
ALA A 164
LEU A 360
LEU A 209
 None
None
None
EGR  A 501 (-3.7A)
None
None
 1.33A 5xxiA-4j0kA:
undetectable		 5xxiA-4j0kA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8s CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF16417
(CNOT1_TTP_bind) 		5 VAL A 928
VAL A 916
GLY A 908
ALA A 947
LEU A 978
 None
 0.76A 5xxiA-4j8sA:
undetectable		 5xxiA-4j8sA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		5 ALA A 240
GLY A 232
ALA A 233
LEU A 207
LEU A 248
 None
 1.09A 5xxiA-4kf7A:
undetectable		 5xxiA-4kf7A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4og1 ENOYL-COA
HYDRATASE/ISOMERASE

(Novosphingobium
aromaticivorans) 		PF00378
(ECH_1) 		5 ALA A 129
VAL A  21
GLY A  44
ALA A  43
LEU A  23
 None
 1.06A 5xxiA-4og1A:
undetectable		 5xxiA-4og1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ALA A 788
VAL A 755
VAL A 715
LEU A 732
LEU A 757
 None
 0.99A 5xxiA-4p72A:
undetectable		 5xxiA-4p72A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe3 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		6 ALA A 133
VAL A 347
ASN A 129
GLY A 125
ALA A 123
LEU A 152
 None
 1.33A 5xxiA-4pe3A:
undetectable		 5xxiA-4pe3A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 ALA A 345
VAL A 324
MET A 938
GLY A 299
LEU A 835
 None
 1.09A 5xxiA-4r7zA:
undetectable		 5xxiA-4r7zA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 ALA A 345
VAL A 324
MET A 938
LEU A 835
LEU A 326
 None
 1.06A 5xxiA-4r7zA:
undetectable		 5xxiA-4r7zA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkz PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1890

(Streptococcus
agalactiae) 		PF03610
(EIIA-man) 		5 VAL A 100
GLY A  25
ALA A  24
LEU A  93
LEU A  96
 None
 1.00A 5xxiA-4tkzA:
undetectable		 5xxiA-4tkzA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7l LEUCINE-RICH REPEATS
AND
IMMUNOGLOBULIN-LIKE
DOMAINS PROTEIN 1

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 ALA A 337
VAL A 357
ALA A 385
LEU A 395
LEU A 373
 None
 0.99A 5xxiA-4u7lA:
undetectable		 5xxiA-4u7lA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ASN A  55
ASP A  28
GLY A  30
ALA A  31
LEU A  75
 None
 0.98A 5xxiA-4wyrA:
undetectable		 5xxiA-4wyrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 ALA A 282
ARG A  96
GLN A 111
GLY A 313
ALA A 314
 None
 0.93A 5xxiA-5c3mA:
undetectable		 5xxiA-5c3mA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c4t NUCLEAR RECEPTOR
ROR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLN A 443
VAL A 363
GLY A 356
ALA A 355
LEU A 433
 None
 0.91A 5xxiA-5c4tA:
undetectable		 5xxiA-5c4tA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		5 ALA A 519
VAL A  56
GLN A 486
GLY A  62
ALA A  61
 None
None
NAG  A 605 (-2.5A)
None
None
 1.07A 5xxiA-5d4kA:
undetectable		 5xxiA-5d4kA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eus PRESTIN,RAT PRESTIN
STAS DOMAIN

(Rattus
norvegicus) 		PF01740
(STAS) 		5 ALA A 547
GLY A 662
ALA A 661
LEU A 701
LEU A 676
 None
None
None
PG4  A 806 ( 4.3A)
None
 1.08A 5xxiA-5eusA:
undetectable		 5xxiA-5eusA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f38 ACETYL-COA
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ASN B  55
ASP B  28
GLY B  30
ALA B  31
LEU B  75
 None
EDO  B 405 (-3.1A)
None
None
None
 0.99A 5xxiA-5f38B:
undetectable		 5xxiA-5f38B:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hst POLYKETIDE SYNTHASE
TYPE I

(Bacillus
amyloliquefaciens) 		PF14765
(PS-DH) 		6 ALA A 229
VAL A  48
ASP A 210
GLY A  56
ALA A  57
LEU A 284
 None
 1.21A 5xxiA-5hstA:
undetectable		 5xxiA-5hstA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 VAL A  31
GLN A  97
GLY A  58
ALA A 103
LEU A 107
 None
 1.02A 5xxiA-5i7nA:
undetectable		 5xxiA-5i7nA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfn CHONDROADHERIN

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8) 		5 VAL A  90
GLY A  93
ALA A 118
LEU A 128
LEU A 106
 None
 1.06A 5xxiA-5lfnA:
undetectable		 5xxiA-5lfnA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nue MALATE DEHYDROGENASE
1, CYTOPLASMIC

(Arabidopsis
thaliana) 		no annotation 5 ALA A 247
VAL A  22
VAL A 130
GLY A  12
ALA A  13
 NAD  A 401 ( 3.7A)
None
NAD  A 401 (-4.3A)
NAD  A 401 (-3.3A)
None
 0.98A 5xxiA-5nueA:
undetectable		 5xxiA-5nueA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		5 VAL A 169
ASN A 272
GLY A 133
ALA A 159
LEU A 244
 None
 1.03A 5xxiA-5u24A:
undetectable		 5xxiA-5u24A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 ALA A 104
VAL A  73
GLY A  15
ALA A  14
LEU A 132
 None
 0.99A 5xxiA-5wgcA:
undetectable		 5xxiA-5wgcA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 5 VAL A  34
GLY A  71
ALA A  72
LEU A  79
LEU A  51
 None
 1.08A 5xxiA-5wknA:
undetectable		 5xxiA-5wknA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 VAL A  45
VAL A  25
MET A  28
LEU A 122
LEU A  49
 None
None
SAH  A 701 ( 3.8A)
None
None
 1.09A 5xxiA-5wp4A:
undetectable		 5xxiA-5wp4A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		5 ALA A 194
VAL A 179
GLY A 255
ALA A 254
LEU A 171
 None
 1.01A 5xxiA-5xfaA:
undetectable		 5xxiA-5xfaA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Clostridium
beijerinckii) 		PF13407
(Peripla_BP_4) 		5 VAL X 143
ASP X 208
GLY X 211
ALA X 212
LEU X 192
 None
 0.86A 5xxiA-5xsjX:
undetectable		 5xxiA-5xsjX:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400) 		no annotation 5 ASN C 197
GLY C 312
ALA C 313
LEU C 400
LEU C 393
 None
 1.10A 5xxiA-5y6qC:
undetectable		 5xxiA-5y6qC:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydl PKS

(Streptomyces
sp. CNQ431) 		no annotation 5 ASP A  37
GLY A  41
ALA A  40
LEU A  24
LEU A  28
 None
 1.02A 5xxiA-5ydlA:
undetectable		 5xxiA-5ydlA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 5 VAL A   9
VAL A 320
GLY A 333
ALA A  19
LEU A   7
 None
 1.07A 5xxiA-6bz0A:
undetectable		 5xxiA-6bz0A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjb CYSTATHIONINE
BETA-LYASE

(Legionella
pneumophila) 		no annotation 5 VAL A 243
VAL A 234
GLY A 210
ALA A 197
LEU A 247
 None
 1.04A 5xxiA-6cjbA:
undetectable		 5xxiA-6cjbA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 5 ASN C 878
GLY C 880
ALA C 881
LEU C 888
LEU C 892
 None
 0.97A 5xxiA-6en4C:
undetectable		 5xxiA-6en4C:
9.67