SIMILAR PATTERNS OF AMINO ACIDS FOR 5XV7_A_EMHA705_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 379
LEU A 302
LEU A 305
ASP A 278
 None
 1.38A 5xv7A-1bdgA:
0.0		 5xv7A-1bdgA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ld9 MHC CLASS I H-2LD
HEAVY CHAIN

(Mus musculus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 VAL A 165
LEU A 168
LEU A 172
ASP A  29
 None
 1.39A 5xv7A-1ld9A:
0.8		 5xv7A-1ld9A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		4 VAL A 409
LEU A 408
LEU A 354
ASP A 253
 None
None
None
MG  A 604 (-3.0A)
 1.48A 5xv7A-1mb9A:
0.0		 5xv7A-1mb9A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1d GLUTAMATE RECEPTOR
INTERACTING PROTEIN

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 VAL A 155
LEU A 154
LEU A 185
ASP A 192
 None
 1.43A 5xv7A-1p1dA:
undetectable		 5xv7A-1p1dA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A  12
LEU A   8
LEU A   7
ASP A  36
 None
 1.31A 5xv7A-1r2jA:
1.1		 5xv7A-1r2jA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 VAL A 413
LEU A 414
LEU A 387
ASP A 313
 None
 1.20A 5xv7A-1r47A:
0.0		 5xv7A-1r47A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 VAL A 419
LEU A 420
LEU A 188
ASP A 357
 None
 1.42A 5xv7A-1s4fA:
0.0		 5xv7A-1s4fA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A  21
LEU A   8
LEU A 102
ASP A  47
 None
 1.47A 5xv7A-1tt7A:
0.0		 5xv7A-1tt7A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		4 VAL A 225
LEU A 226
LEU A 346
ASP A 413
 None
 1.18A 5xv7A-1vl4A:
undetectable		 5xv7A-1vl4A:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0e PUTATIVE
N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE

(Staphylococcus
aureus) 		PF04131
(NanE) 		4 VAL A 169
LEU A 166
LEU A 195
ASP A 162
 None
 1.49A 5xv7A-1y0eA:
undetectable		 5xv7A-1y0eA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z21 YOP PROTEINS
TRANSLOCATION
PROTEIN H

(Yersinia pestis) 		PF09025
(T3SS_needle_reg) 		4 VAL A  49
LEU A  50
LEU A  68
ASP A 104
 None
 1.44A 5xv7A-1z21A:
undetectable		 5xv7A-1z21A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 2

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 VAL I 453
LEU I 454
LEU I 465
ASP I 411
 None
 1.01A 5xv7A-1zo1I:
undetectable		 5xv7A-1zo1I:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COA
CARBOXYLASE,
CARBOXYLTRANSFERASE
ALPHA CHAIN

(Escherichia
coli) 		PF03255
(ACCA) 		4 VAL A 299
LEU A 300
LEU A 305
ASP A 215
 None
 1.16A 5xv7A-2f9yA:
undetectable		 5xv7A-2f9yA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		4 VAL A 264
LEU A 263
LEU A 221
ASP A 225
 None
 0.74A 5xv7A-2fv2A:
undetectable		 5xv7A-2fv2A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh4 PUTATIVE GLYCOSYL
HYDROLASE YTER

(Bacillus
subtilis) 		PF07470
(Glyco_hydro_88) 		4 VAL A 109
LEU A  96
LEU A  99
ASP A  71
 None
 1.40A 5xv7A-2gh4A:
undetectable		 5xv7A-2gh4A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghp U4/U6
SNRNA-ASSOCIATED
SPLICING FACTOR
PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 VAL A  45
LEU A  44
LEU A 114
ASP A 164
 None
 1.01A 5xv7A-2ghpA:
undetectable		 5xv7A-2ghpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 VAL A 405
LEU A 408
LEU A 414
ASP A 256
 None
 1.43A 5xv7A-2gwcA:
0.4		 5xv7A-2gwcA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwn DIHYDROOROTASE

(Porphyromonas
gingivalis) 		PF01979
(Amidohydro_1) 		4 VAL A  21
LEU A   4
LEU A  42
ASP A  40
 None
 1.48A 5xv7A-2gwnA:
undetectable		 5xv7A-2gwnA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 VAL A 197
LEU A 170
LEU A 182
ASP A 252
 None
 1.25A 5xv7A-2hnhA:
0.6		 5xv7A-2hnhA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		4 VAL A  50
LEU A  54
LEU A  55
ASP A 256
 None
 1.34A 5xv7A-2p1fA:
undetectable		 5xv7A-2p1fA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		4 VAL A 239
LEU A 243
LEU A 244
ASP A 445
 None
 1.35A 5xv7A-2qcmA:
undetectable		 5xv7A-2qcmA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvf PUTATIVE
NICKEL-RESPONSIVE
REGULATOR

(Helicobacter
pylori) 		PF01402
(RHH_1)
PF08753
(NikR_C) 		4 VAL A  15
LEU A  17
LEU A  22
ASP A  26
 None
 1.37A 5xv7A-2wvfA:
2.2		 5xv7A-2wvfA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bbj PUTATIVE
THIOESTERASE II

(Thermobifida
fusca) 		PF13622
(4HBT_3) 		4 VAL A 198
LEU A 252
LEU A 232
ASP A 178
 None
 1.43A 5xv7A-3bbjA:
1.4		 5xv7A-3bbjA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eei 5-METHYLTHIOADENOSIN
E
NUCLEOSIDASE/S-ADENO
SYLHOMOCYSTEINE
NUCLEOSIDASE

(Neisseria
meningitidis) 		PF01048
(PNP_UDP_1) 		4 VAL A 230
LEU A 233
LEU A   3
ASP A 125
 None
 1.34A 5xv7A-3eeiA:
undetectable		 5xv7A-3eeiA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1u ADENOSYLHOMOCYSTEINA
SE

(Leishmania
major) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 VAL A 365
LEU A 366
LEU A 391
ASP A 396
 None
 1.34A 5xv7A-3g1uA:
undetectable		 5xv7A-3g1uA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1q ETHANOLAMINE
UTILIZATION PROTEIN
EUTJ

(Carboxydothermus
hydrogenoformans) 		PF14450
(FtsA) 		4 VAL A 260
LEU A 259
LEU A 258
ASP A  36
 None
None
ATP  A 301 (-3.8A)
ATP  A 301 (-2.5A)
 1.36A 5xv7A-3h1qA:
undetectable		 5xv7A-3h1qA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbu SECRETED PROTEASE C

(Dickeya
chrysanthemi) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 VAL P 369
LEU P 370
LEU P 361
ASP P 377
 None
None
None
CA  P 483 ( 2.4A)
 1.05A 5xv7A-3hbuP:
undetectable		 5xv7A-3hbuP:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 VAL A 266
LEU A 261
LEU A 416
ASP A  56
 None
 1.46A 5xv7A-3hjrA:
undetectable		 5xv7A-3hjrA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A  40
LEU A  18
LEU A  20
ASP A 338
 None
 1.27A 5xv7A-3i6eA:
undetectable		 5xv7A-3i6eA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A  38
LEU A  16
LEU A  18
ASP A 334
 None
 1.22A 5xv7A-3i6tA:
undetectable		 5xv7A-3i6tA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		4 VAL W1004
LEU W 708
LEU W 799
ASP W 702
 None
 1.48A 5xv7A-3iylW:
0.7		 5xv7A-3iylW:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 VAL A 353
LEU A 355
LEU A 358
ASP A 321
 None
 1.47A 5xv7A-3j3iA:
undetectable		 5xv7A-3j3iA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv5 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Mus musculus) 		PF16179
(RHD_dimer) 		4 VAL A 260
LEU A 309
LEU A 228
ASP A 316
 None
 1.49A 5xv7A-3jv5A:
undetectable		 5xv7A-3jv5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		4 VAL A  80
LEU A  79
LEU A 224
ASP A 243
 None
 1.45A 5xv7A-3muqA:
undetectable		 5xv7A-3muqA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ny7 SULFATE TRANSPORTER

(Escherichia
coli) 		PF01740
(STAS) 		4 VAL A 452
LEU A 453
LEU A 439
ASP A 470
 None
 1.48A 5xv7A-3ny7A:
undetectable		 5xv7A-3ny7A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 VAL A 366
LEU A 223
LEU A 283
ASP A 232
 None
 1.50A 5xv7A-3oepA:
undetectable		 5xv7A-3oepA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		4 VAL A 385
LEU A 386
LEU A 522
ASP A 528
 None
 1.39A 5xv7A-3t8lA:
undetectable		 5xv7A-3t8lA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vi1 ALKALINE
METALLOPROTEINASE

(Pseudomonas
aeruginosa) 		PF08548
(Peptidase_M10_C)
PF13583
(Reprolysin_4) 		4 VAL A 348
LEU A 349
LEU A 340
ASP A 356
 None
None
None
CA  A 503 ( 2.5A)
 1.10A 5xv7A-3vi1A:
undetectable		 5xv7A-3vi1A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu7 DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF16727
(REV1_C) 		4 VAL H1239
LEU H1240
LEU H1248
ASP H1207
 None
 1.42A 5xv7A-3vu7H:
undetectable		 5xv7A-3vu7H:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmd PROBABLE MONENSIN
BIOSYNTHESIS
ISOMERASE

(Streptomyces
cinnamonensis) 		PF12680
(SnoaL_2) 		4 VAL A  85
LEU A  62
LEU A  57
ASP A  37
 None
 1.09A 5xv7A-3wmdA:
undetectable		 5xv7A-3wmdA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbj 6-PHOSPHOGLUCONATE
DEHYDROGENASE
NAD-BINDING

(Dyadobacter
fermentans) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 VAL A 169
LEU A 172
LEU A 244
ASP A  69
 None
 1.26A 5xv7A-4gbjA:
undetectable		 5xv7A-4gbjA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk5 DNA REPAIR PROTEIN
REV1

(Homo sapiens) 		PF16727
(REV1_C) 		4 VAL E1239
LEU E1240
LEU E1248
ASP E1207
 None
 1.48A 5xv7A-4gk5E:
undetectable		 5xv7A-4gk5E:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		4 VAL A 242
LEU A 215
LEU A 227
ASP A 297
 None
 1.26A 5xv7A-4gx8A:
undetectable		 5xv7A-4gx8A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf8 TRWG COMPONENT OF
TYPE IV SECRETION
SYSTEM

(Bartonella
birtlesii) 		PF04335
(VirB8) 		4 VAL A 219
LEU A 127
LEU A 126
ASP A 209
 None
 1.49A 5xv7A-4jf8A:
2.7		 5xv7A-4jf8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 VAL A 462
LEU A 463
LEU A 496
ASP A 454
 None
 1.34A 5xv7A-4jhzA:
undetectable		 5xv7A-4jhzA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk5 ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 VAL A 245
LEU A 246
LEU A 149
ASP A 152
 None
 1.24A 5xv7A-4lk5A:
undetectable		 5xv7A-4lk5A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mxn UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF00295
(Glyco_hydro_28) 		4 VAL A  37
LEU A  67
LEU A  39
ASP A  95
 None
 1.45A 5xv7A-4mxnA:
undetectable		 5xv7A-4mxnA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16842
(RRM_occluded) 		4 VAL A  45
LEU A  44
LEU A 114
ASP A 164
 None
 1.02A 5xv7A-4n0tA:
undetectable		 5xv7A-4n0tA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 VAL A4581
LEU A4582
LEU A4479
ASP A4325
 None
 1.20A 5xv7A-4opeA:
undetectable		 5xv7A-4opeA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 VAL A 123
LEU A 122
LEU A 127
ASP A 243
 None
 1.44A 5xv7A-4p6vA:
undetectable		 5xv7A-4p6vA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		4 VAL A  35
LEU A  38
LEU A  73
ASP A  75
 None
 1.05A 5xv7A-4r1iA:
undetectable		 5xv7A-4r1iA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 VAL A 390
LEU A 375
LEU A  47
ASP A 380
 None
 1.29A 5xv7A-4r85A:
undetectable		 5xv7A-4r85A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		4 VAL A 123
LEU A 122
LEU A 127
ASP A 243
 None
 1.45A 5xv7A-4u9oA:
undetectable		 5xv7A-4u9oA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5j ADENYLATE KINASE

(Streptococcus
pneumoniae) 		PF00406
(ADK) 		4 VAL A 188
LEU A 187
LEU A 108
ASP A  98
 None
 1.19A 5xv7A-4w5jA:
undetectable		 5xv7A-4w5jA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xt0 PROTEIN LIGF

(Sphingobium sp.
SYK-6) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 VAL A 171
LEU A 174
LEU A 178
ASP A 193
 None
 1.47A 5xv7A-4xt0A:
undetectable		 5xv7A-4xt0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
FAD-BINDING SUBUNIT
PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 VAL B 264
LEU B 267
LEU B 179
ASP A 578
 None
 1.41A 5xv7A-4zohB:
undetectable		 5xv7A-4zohB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvw BIFUNCTIONAL
HEMOLYSIN/ADENYLATE
CYCLASE

(Bordetella
pertussis) 		PF00353
(HemolysinCabind)
PF06594
(HCBP_related) 		4 VAL A1544
LEU A1545
LEU A1536
ASP A1552
 None
EDO  A1709 (-4.2A)
EDO  A1709 (-4.3A)
CA  A1704 ( 2.4A)
 1.16A 5xv7A-5cvwA:
undetectable		 5xv7A-5cvwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 VAL A 357
LEU A 358
LEU A 349
ASP A 365
 VAL  A 357 ( 0.6A)
LEU  A 358 ( 0.5A)
LEU  A 349 ( 0.6A)
ASP  A 365 ( 0.5A)
 1.05A 5xv7A-5d7wA:
undetectable		 5xv7A-5d7wA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 VAL A  91
LEU A   5
LEU A  86
ASP A  31
 None
 1.41A 5xv7A-5dldA:
undetectable		 5xv7A-5dldA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed7 TEGUMENT PROTEIN
UL21

(Human
alphaherpesvirus
1) 		PF03252
(Herpes_UL21) 		4 VAL A 428
LEU A 463
LEU A 466
ASP A 400
 None
 1.37A 5xv7A-5ed7A:
undetectable		 5xv7A-5ed7A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 VAL A 410
LEU A 398
LEU A 413
ASP A 349
 None
None
PO4  A 708 (-4.5A)
None
 1.26A 5xv7A-5gjeA:
undetectable		 5xv7A-5gjeA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 VAL B 731
LEU B 719
LEU B 734
ASP B 670
 None
 1.29A 5xv7A-5gjeB:
2.6		 5xv7A-5gjeB:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm7 AEROBACTIN SYNTHASE
IUCA

(Klebsiella
pneumoniae) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		4 VAL A  88
LEU A  91
LEU A  95
ASP A 557
 None
 1.47A 5xv7A-5jm7A:
5.2		 5xv7A-5jm7A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5x DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA135

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF06883
(RNA_pol_Rpa2_4) 		4 VAL B 358
LEU B 359
LEU B 362
ASP B 369
 None
 1.45A 5xv7A-5m5xB:
undetectable		 5xv7A-5m5xB:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3y TWO-COMPONENT SYSTEM
RESPONSE REGULATOR

(Burkholderia
multivorans) 		PF00072
(Response_reg) 		4 VAL A 111
LEU A 112
LEU A  18
ASP A   9
 None
 1.40A 5xv7A-5t3yA:
undetectable		 5xv7A-5t3yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkw ADENYLOSUCCINATE
LYASE

(Candida
albicans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 VAL A 232
LEU A 192
LEU A 118
ASP A 114
 None
 1.38A 5xv7A-5vkwA:
undetectable		 5xv7A-5vkwA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi5 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		4 VAL A  42
LEU A  43
LEU A  29
ASP A 197
 None
 1.47A 5xv7A-5wi5A:
undetectable		 5xv7A-5wi5A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwl CENTROMERE PROTEIN
MIS12
KINETOCHORE PROTEIN
NNF1

(Schizosaccharomyces
pombe) 		no annotation 4 VAL M 121
LEU M 120
LEU N 124
ASP N 128
 None
 1.03A 5xv7A-5wwlM:
undetectable		 5xv7A-5wwlM:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6r GENOME POLYPROTEIN

(Pestivirus C) 		no annotation 4 VAL A 419
LEU A 420
LEU A 188
ASP A 357
 None
 1.26A 5xv7A-5y6rA:
undetectable		 5xv7A-5y6rA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 4 VAL A1029
LEU A1033
LEU A 924
ASP A1050
 None
 1.42A 5xv7A-5yimA:
1.8		 5xv7A-5yimA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwe PUTATIVE FIMBRIAL
ASSOCIATED
SORTASE-LIKE PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 4 VAL A 234
LEU A 233
LEU A 207
ASP A 204
 None
 1.36A 5xv7A-6bweA:
undetectable		 5xv7A-6bweA:
21.74