SIMILAR PATTERNS OF AMINO ACIDS FOR 5XV7_A_EMHA705_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 LEU A 214
GLY A 213
GLY A 209
VAL A  85
LEU A 180
 None
 0.98A 5xv7A-1a4sA:
undetectable		 5xv7A-1a4sA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 LEU A 256
GLY A 257
GLY A 450
LEU A 427
ALA A 249
 None
 0.87A 5xv7A-1bp1A:
undetectable		 5xv7A-1bp1A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		5 LEU A 181
GLY A 178
VAL A 175
ALA A 201
ALA A 213
 None
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.1A)
None
None
 0.73A 5xv7A-1d6sA:
undetectable		 5xv7A-1d6sA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpp ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint) 		5 LEU A 167
GLY A 168
VAL A 171
PHE A 155
VAL A 120
 None
 0.99A 5xv7A-1gppA:
undetectable		 5xv7A-1gppA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 GLY A 581
VAL A 588
ALA A 606
PHE A 654
ALA A 741
 None
 0.63A 5xv7A-1lufA:
21.1		 5xv7A-1lufA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nog CONSERVED
HYPOTHETICAL PROTEIN
TA0546

(Thermoplasma
acidophilum) 		PF01923
(Cob_adeno_trans) 		5 GLY A 108
ALA A 157
PHE A 154
TYR A  41
LEU A  45
 None
 0.73A 5xv7A-1nogA:
undetectable		 5xv7A-1nogA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdk PROTEIN (PROTEIN
PAPK)

(Escherichia
coli) 		PF00419
(Fimbrial) 		5 GLY B  40
ALA B 135
GLY B  90
VAL B  81
TYR B 146
 None
 0.93A 5xv7A-1pdkB:
undetectable		 5xv7A-1pdkB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pss PHOTOSYNTHETIC
REACTION CENTER

(Rhodobacter
sphaeroides) 		PF00124
(Photo_RC) 		5 LEU L 195
GLY L 191
VAL L 194
ALA L 198
GLY M 264
 None
 0.98A 5xv7A-1pssL:
undetectable		 5xv7A-1pssL:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 164
GLY A 165
VAL A 172
ALA A 185
PHE A 246
GLY A 250
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
 0.63A 5xv7A-1q8yA:
31.5		 5xv7A-1q8yA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 164
VAL A 172
ALA A 185
PHE A 246
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
 0.51A 5xv7A-1q8yA:
31.5		 5xv7A-1q8yA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)

(Burkholderia
glumae) 		PF00561
(Abhydrolase_1) 		5 LEU D  65
GLY D  62
ALA D  47
GLY D  89
ALA D  18
 None
 0.94A 5xv7A-1qgeD:
undetectable		 5xv7A-1qgeD:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
GLY A 617
VAL A 624
ALA A 642
PHE A 691
 None
 0.45A 5xv7A-1rjbA:
19.8		 5xv7A-1rjbA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae) 		no annotation 5 LEU B  65
GLY B  62
ALA B  47
GLY B  89
ALA B  18
 None
 0.97A 5xv7A-1tahB:
undetectable		 5xv7A-1tahB:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  18
GLY A  19
VAL A  26
ALA A  39
PHE A  91
ALA A 154
 ATP  A 381 (-4.4A)
ATP  A 381 ( 3.9A)
ATP  A 381 (-4.0A)
ATP  A 381 (-3.6A)
None
None
 0.46A 5xv7A-1ua2A:
24.4		 5xv7A-1ua2A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A  11
VAL A  18
ALA A  30
PHE A  79
ALA A 142
 None
 0.59A 5xv7A-1v0bA:
25.6		 5xv7A-1v0bA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		5 LEU A  19
GLY A  20
VAL A  27
ALA A  40
PHE A  89
 None
 0.32A 5xv7A-2bdwA:
25.3		 5xv7A-2bdwA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 162
GLY A 163
VAL A 170
ALA A 184
PHE A 236
ALA A 319
 None
 0.53A 5xv7A-2eu9A:
36.7		 5xv7A-2eu9A:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 ( 4.0A)
 0.56A 5xv7A-2h8hA:
21.1		 5xv7A-2h8hA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
GLY A 274
VAL A 281
GLY A 344
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.70A 5xv7A-2h8hA:
21.1		 5xv7A-2h8hA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 ( 4.5A)
 0.63A 5xv7A-2hckA:
20.3		 5xv7A-2hckA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
GLY A 274
VAL A 281
GLY A 344
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.2A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.0A)
QUE  A   1 ( 4.5A)
 0.76A 5xv7A-2hckA:
20.3		 5xv7A-2hckA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
GLY A 252
VAL A 259
ALA A 271
ALA A 381
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 ( 3.7A)
 0.37A 5xv7A-2hk5A:
23.6		 5xv7A-2hk5A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
GLY A 252
VAL A 259
GLY A 322
ALA A 381
 1BM  A 499 ( 3.7A)
None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.54A 5xv7A-2hk5A:
23.6		 5xv7A-2hk5A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  55
GLY A  56
VAL A  63
ALA A  76
PHE A 124
 None
 0.51A 5xv7A-2hw6A:
22.8		 5xv7A-2hw6A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  11
VAL A  18
ALA A  31
PHE A  80
ALA A 144
 None
 0.42A 5xv7A-2jgzA:
19.9		 5xv7A-2jgzA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
GLY A 252
VAL A 259
ALA A 271
ALA A 381
 None
None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
 0.73A 5xv7A-2og8A:
20.7		 5xv7A-2og8A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 344
GLY A 345
VAL A 352
ALA A 367
GLY A 418
 ANP  A 615 (-4.4A)
ANP  A 615 ( 4.4A)
ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 4.0A)
 0.60A 5xv7A-2ozoA:
19.8		 5xv7A-2ozoA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A 276
VAL A 299
ALA A 196
LEU A 326
ALA A 203
 None
 0.99A 5xv7A-2panA:
undetectable		 5xv7A-2panA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		5 LEU A  25
GLY A  26
VAL A  33
ALA A  46
PHE A 103
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
 0.29A 5xv7A-2phkA:
25.8		 5xv7A-2phkA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 253
GLY A 254
VAL A 261
GLY A 325
ALA A 384
 None
 0.72A 5xv7A-2zv7A:
23.6		 5xv7A-2zv7A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 487
GLY A 488
VAL A 495
ALA A 515
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
 0.52A 5xv7A-3b2tA:
15.5		 5xv7A-3b2tA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 VAL A 352
ALA A 563
GLY A 558
HIS A 555
ALA A 483
 None
 0.84A 5xv7A-3cdiA:
undetectable		 5xv7A-3cdiA:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dea CUTINASE

(Colletotrichum
gloeosporioides) 		PF01083
(Cutinase) 		5 GLY A 138
VAL A 141
ALA A 114
GLY A  88
TYR A  51
 None
 0.96A 5xv7A-3deaA:
undetectable		 5xv7A-3deaA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5s METHYLENETETRAHYDROF
OLATE--TRNA-(URACIL-
5-)-METHYLTRANSFERAS
E TRMFO

(Thermus
thermophilus) 		PF01134
(GIDA) 		5 LEU A 337
GLY A 134
ALA A 333
GLY A 339
LEU A 154
 None
FAD  A 444 (-3.2A)
None
None
None
 0.98A 5xv7A-3g5sA:
undetectable		 5xv7A-3g5sA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 260
VAL A 121
GLY A 215
VAL A  92
LEU A  76
 None
 0.95A 5xv7A-3gyrA:
undetectable		 5xv7A-3gyrA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 5 LEU B  40
GLY B  41
VAL B  48
ALA B  61
ALA B 173
 None
 0.71A 5xv7A-3h4jB:
16.1		 5xv7A-3h4jB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A 559
VAL A 566
ALA A 579
PHE A 630
GLY A 634
 ANP  A 877 (-3.8A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
None
None
 0.71A 5xv7A-3lltA:
34.6		 5xv7A-3lltA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 171
GLY A 172
VAL A 179
ALA A 192
PHE A 240
 FEF  A 668 ( 3.8A)
FEF  A 668 ( 4.2A)
FEF  A 668 (-4.9A)
FEF  A 668 (-3.3A)
FEF  A 668 ( 4.3A)
 0.43A 5xv7A-3mtlA:
15.5		 5xv7A-3mtlA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 GLY A  30
VAL A  37
ALA A  49
PHE A  98
ALA A 161
 ADP  A 314 (-3.3A)
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
None
None
 0.50A 5xv7A-3nizA:
30.1		 5xv7A-3nizA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nsj PERFORIN-1

(Mus musculus) 		PF00168
(C2)
PF01823
(MACPF) 		5 LEU A 493
GLY A 494
VAL A 481
ALA A 436
HIS A 513
 None
 0.59A 5xv7A-3nsjA:
undetectable		 5xv7A-3nsjA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		5 GLY A 108
ALA A 401
GLY A 387
LEU A 353
ALA A 406
 None
 0.93A 5xv7A-3rv6A:
undetectable		 5xv7A-3rv6A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 423
GLY A 424
VAL A 431
ALA A 443
GLY A 495
 PP2  A   1 (-4.1A)
PP2  A   1 ( 4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.2A)
 0.60A 5xv7A-3sxsA:
22.4		 5xv7A-3sxsA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 ARG A  76
GLY A  44
ALA A  82
PHE A  87
GLY A  90
 ARG  A  76 (-0.6A)
GLY  A  44 (-0.0A)
ALA  A  82 ( 0.0A)
PHE  A  87 ( 1.3A)
GLY  A  90 ( 0.0A)
 0.83A 5xv7A-3ulkA:
undetectable		 5xv7A-3ulkA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		5 LEU A 444
GLY A 443
GLY A 436
LEU A 326
ALA A 417
 None
None
FAD  A 801 (-3.4A)
None
None
 0.92A 5xv7A-3umvA:
undetectable		 5xv7A-3umvA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		5 GLY A 341
VAL A 339
GLY A 386
VAL A 475
ALA A 367
 None
 0.81A 5xv7A-3vsmA:
undetectable		 5xv7A-3vsmA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 GLY A  32
VAL A  74
ALA A  72
LEU A  41
ALA A  91
 None
 0.95A 5xv7A-3zpcA:
undetectable		 5xv7A-3zpcA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzw TYROSINE-PROTEIN
KINASE TRANSMEMBRANE
RECEPTOR ROR2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 479
GLY A 480
VAL A 487
ALA A 505
PHE A 553
 None
 0.59A 5xv7A-3zzwA:
19.4		 5xv7A-3zzwA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ARG A  81
LEU A  83
GLY A  84
VAL A  91
ALA A 104
 None
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
 0.75A 5xv7A-4af3A:
19.5		 5xv7A-4af3A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 350
VAL A 347
ALA A 201
GLY A 195
LEU A 325
 None
 0.96A 5xv7A-4aw5A:
21.3		 5xv7A-4aw5A:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  42
GLY A  43
VAL A  50
ALA A  63
ALA A 174
 XZN  A1317 (-3.6A)
XZN  A1317 ( 4.9A)
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 ( 4.3A)
 0.44A 5xv7A-4bc6A:
22.0		 5xv7A-4bc6A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
GLY A 617
VAL A 624
ALA A 653
ALA A 783
 None
None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.7A)
 0.48A 5xv7A-4ckrA:
20.4		 5xv7A-4ckrA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 515
GLY A 516
VAL A 523
ALA A 541
PHE A 588
 None
 0.25A 5xv7A-4f0iA:
20.1		 5xv7A-4f0iA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 377
GLY A 378
VAL A 385
ALA A 400
GLY A 454
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.5A)
 0.56A 5xv7A-4f4pA:
23.1		 5xv7A-4f4pA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 514
GLY A 515
VAL A 522
ALA A 538
ALA A 662
 0T8  A 901 (-3.6A)
0T8  A 901 ( 3.9A)
0T8  A 901 ( 4.4A)
0T8  A 901 (-3.2A)
0T8  A 901 ( 4.5A)
 0.32A 5xv7A-4feqA:
19.2		 5xv7A-4feqA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 (-3.5A)
 0.34A 5xv7A-4k11A:
20.6		 5xv7A-4k11A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
GLY A 274
VAL A 281
GLY A 344
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.1A)
0J9  A 601 (-3.5A)
 0.64A 5xv7A-4k11A:
20.6		 5xv7A-4k11A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  33
GLY A  34
VAL A  41
ALA A  54
ALA A 163
 GOL  A 404 ( 3.6A)
None
GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 3.0A)
 0.34A 5xv7A-4lg4A:
23.5		 5xv7A-4lg4A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
GLY A 274
VAL A 281
ALA A 293
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.2A)
 0.45A 5xv7A-4lggA:
20.7		 5xv7A-4lggA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 273
GLY A 274
VAL A 281
GLY A 344
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.8A)
VGG  A 601 ( 3.5A)
VGG  A 601 ( 3.2A)
VGG  A 601 ( 4.2A)
 0.71A 5xv7A-4lggA:
20.7		 5xv7A-4lggA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		5 LEU A  84
GLY A  17
VAL A 219
TYR A 180
ALA A  52
 None
 0.98A 5xv7A-4lw8A:
undetectable		 5xv7A-4lw8A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN

(Thermomonospora
curvata) 		PF13458
(Peripla_BP_6) 		5 LEU A 189
GLY A 190
VAL A 217
ALA A 210
LEU A 177
 None
 0.84A 5xv7A-4n03A:
undetectable		 5xv7A-4n03A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsp ENDONUCLEASE V

(Homo sapiens) 		PF04493
(Endonuclease_5) 		5 LEU A 124
GLY A  50
VAL A 236
GLY A 152
LEU A 223
 None
 0.97A 5xv7A-4nspA:
undetectable		 5xv7A-4nspA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		5 GLY A  82
VAL A  88
ALA A  35
PHE A  68
GLY A  74
 None
 0.76A 5xv7A-4p47A:
undetectable		 5xv7A-4p47A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 386
GLY A 387
VAL A 394
ALA A 407
ALA A 521
 PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
PZW  A 801 ( 4.6A)
 0.21A 5xv7A-4q9zA:
24.3		 5xv7A-4q9zA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 LEU A 345
GLY A 346
VAL A 353
ALA A 366
ALA A 480
 3KZ  A 701 ( 4.1A)
3KZ  A 701 (-3.3A)
3KZ  A 701 (-3.9A)
3KZ  A 701 (-3.4A)
3KZ  A 701 ( 4.8A)
 0.33A 5xv7A-4ra4A:
24.3		 5xv7A-4ra4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4red 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  24
GLY A  25
VAL A  32
ALA A  45
ALA A 158
 None
 0.70A 5xv7A-4redA:
18.5		 5xv7A-4redA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
GLY A 617
VAL A 624
ALA A 642
PHE A 691
 P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.7A)
 0.19A 5xv7A-4rt7A:
20.9		 5xv7A-4rt7A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		6 ARG A 178
LEU A 180
GLY A 181
VAL A 200
ALA A 146
PHE A 142
 None
 0.62A 5xv7A-4u98A:
9.3		 5xv7A-4u98A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LEU A  14
GLY A  15
VAL A  22
ALA A  35
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
 0.49A 5xv7A-4ueuA:
23.3		 5xv7A-4ueuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 LEU A  14
GLY A  15
VAL A  22
GLY A  87
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.2A)
ACP  A1264 (-4.7A)
ACP  A1264 (-3.5A)
None
 0.60A 5xv7A-4ueuA:
23.3		 5xv7A-4ueuA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A 301
VAL A 275
ALA A 272
GLY A  20
VAL A  23
 None
 0.90A 5xv7A-4utgA:
undetectable		 5xv7A-4utgA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 473
GLY A 474
VAL A 481
ALA A 501
ALA A 629
 40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.0A)
 0.55A 5xv7A-4xcuA:
21.2		 5xv7A-4xcuA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
GLY A 617
VAL A 624
ALA A 642
PHE A 691
 P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.3A)
 0.47A 5xv7A-4xufA:
20.6		 5xv7A-4xufA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		5 GLY A 226
VAL A 224
ALA A 184
VAL A 128
ALA A 175
 None
 0.92A 5xv7A-4y90A:
undetectable		 5xv7A-4y90A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  11
VAL A  18
ALA A  31
PHE A  80
ALA A 145
 None
 0.50A 5xv7A-4yc6A:
26.0		 5xv7A-4yc6A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ynz SERINE/THREONINE-PRO
TEIN KINASE BRSK2

(Mus musculus) 		PF00069
(Pkinase) 		5 LEU A  26
GLY A  27
VAL A  34
ALA A  47
ALA A 159
 None
 0.42A 5xv7A-4ynzA:
21.8		 5xv7A-4ynzA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
GLY A 485
VAL A 492
ALA A 512
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 ( 4.4A)
 0.47A 5xv7A-5a46A:
21.1		 5xv7A-5a46A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7l CONTACTIN-2

(Mus musculus) 		PF00041
(fn3) 		5 LEU A 719
GLY A 718
ALA A 805
GLY A 721
LEU A 750
 None
 0.66A 5xv7A-5e7lA:
undetectable		 5xv7A-5e7lA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		5 LEU A  99
GLY A 100
VAL A 107
ALA A 120
ALA A 233
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
None
 0.46A 5xv7A-5eykA:
19.5		 5xv7A-5eykA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A 901
LEU A 903
GLY A 904
VAL A 911
ALA A 928
 5U3  A1200 ( 4.1A)
5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
 0.46A 5xv7A-5f1zA:
22.6		 5xv7A-5f1zA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 LEU A  20
GLY A  21
VAL A  28
ALA A  41
PHE A  90
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.6A)
ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
 0.31A 5xv7A-5hu3A:
27.6		 5xv7A-5hu3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  28
VAL A  35
ALA A  50
PHE A  97
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-3.8A)
6A7  A 401 ( 4.1A)
 0.37A 5xv7A-5idnA:
26.5		 5xv7A-5idnA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 LEU A 350
GLY A 349
VAL A 307
LEU A 335
ALA A 166
 None
 0.97A 5xv7A-5jouA:
undetectable		 5xv7A-5jouA:
6.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy7 MALTOKINASE

(Mycolicibacterium
smegmatis) 		PF01636
(APH) 		5 LEU I 176
GLY I 177
VAL I 193
ALA I 142
PHE I 138
 None
 0.49A 5xv7A-5jy7I:
9.2		 5xv7A-5jy7I:
15.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		10 ARG A  96
LEU A  98
GLY A  99
VAL A 106
ALA A 119
PHE A 177
GLY A 181
VAL A 235
TYR A 239
ALA A 540
 None
W4A  A 716 (-4.1A)
W4A  A 716 ( 4.0A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 ( 3.9A)
W4A  A 716 (-3.8A)
W4A  A 716 ( 4.9A)
W4A  A 716 (-4.8A)
DMS  A 717 ( 4.5A)
 0.46A 5xv7A-5myvA:
49.0		 5xv7A-5myvA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ARG A  96
PHE A 177
GLY A 181
HIS A 182
VAL A 235
TYR A 239
ALA A 540
 None
DMS  A 717 ( 3.9A)
W4A  A 716 (-3.8A)
W4A  A 716 ( 3.6A)
W4A  A 716 ( 4.9A)
W4A  A 716 (-4.8A)
DMS  A 717 ( 4.5A)
 0.80A 5xv7A-5myvA:
49.0		 5xv7A-5myvA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  98
GLY A  99
VAL A 106
ALA A 119
PHE A 177
VAL A 240
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.0A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 ( 3.9A)
None
 1.22A 5xv7A-5myvA:
49.0		 5xv7A-5myvA:
86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 593
GLY A 594
VAL A 601
ALA A 617
ALA A 740
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.2A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 ( 3.7A)
 0.28A 5xv7A-5td2A:
19.7		 5xv7A-5td2A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 5 LEU A  44
GLY A  45
VAL A  52
ALA A  65
VAL A 126
 None
None
7LK  A 401 (-4.9A)
7LK  A 401 (-3.3A)
None
 0.86A 5xv7A-5turA:
23.8		 5xv7A-5turA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ARG A 383
LEU A 385
GLY A 386
VAL A 376
ALA A 351
 None
 0.64A 5xv7A-5vohA:
undetectable		 5xv7A-5vohA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 GLY A 172
VAL A 179
ALA A 192
PHE A 267
ALA A 329
 BI9  A 501 (-3.6A)
BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
BI9  A 501 ( 4.2A)
NH4  A 506 ( 3.7A)
 0.31A 5xv7A-6bqlA:
25.5		 5xv7A-6bqlA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 5 LEU A  22
GLY A  23
VAL A  30
ALA A  43
ALA A 156
 EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
None
EDJ  A 301 (-3.4A)
EDJ  A 301 (-3.2A)
 0.55A 5xv7A-6bx6A:
18.6		 5xv7A-6bx6A:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 GLY A 135
VAL A 142
ALA A 155
PHE A 230
ALA A 292
 H1N  A 501 ( 3.8A)
H1N  A 501 (-4.4A)
H1N  A 501 (-3.4A)
H1N  A 501 (-3.7A)
H1N  A 501 ( 3.9A)
 0.30A 5xv7A-6ccfA:
25.1		 5xv7A-6ccfA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 5 LEU U  20
GLY U  21
VAL U  28
ALA U  42
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.9A)
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.2A)
 0.49A 5xv7A-6fdyU:
24.0		 5xv7A-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 LEU A 169
GLY A 170
VAL A 177
ALA A 191
PHE A 243
GLY A 247
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.5A)
None
 0.62A 5xv7A-6fylA:
37.1		 5xv7A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
GLY A 168
VAL A 175
ALA A 189
PHE A 241
 EAQ  A 501 (-3.9A)
None
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
 0.13A 5xv7A-6fyoA:
35.7		 5xv7A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 5 LEU A 167
VAL A 175
ALA A 189
PHE A 241
GLY A 245
 EAQ  A 501 (-3.9A)
None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.5A)
EAQ  A 501 (-3.9A)
 0.58A 5xv7A-6fyoA:
35.7		 5xv7A-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 5 LEU A 167
GLY A 168
VAL A 175
ALA A 189
PHE A 241
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-3.5A)
 0.34A 5xv7A-6fyvA:
36.2		 5xv7A-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 410
GLY A 406
ALA A 413
LEU A 390
ALA A 444
 None
 0.99A 5xv7A-9rubA:
undetectable		 5xv7A-9rubA:
10.00